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During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/publications"},"_namespace":null},{"id":9082,"version":2,"created":1554922273000,"modified":1554922275000,"deprecated":false,"name":"NACHT, LRR and PYD domains-containing protein 11","accession":"P59045","gene":"NLRP11","description":"Involved in inflammation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.845297187972665,"antibodyCount":80,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.456612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.941884404224915,"pubTatorScore":0.7721962420537455,"self":"https://pharos.nih.gov/idg/api/v1/targets(9082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/properties"},"_links":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/publications"},"_namespace":null},{"id":9083,"version":2,"created":1554922275000,"modified":1554922278000,"deprecated":false,"name":"60S ribosomal protein L27","accession":"P61353","gene":"RPL27","description":"Component of the large ribosomal subunit (PubMed:12962325). 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Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1774334551606922,"antibodyCount":235,"monoclonalCount":60,"pubmedCount":null,"jensenScore":12.607995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.72478922049963,"pubTatorScore":1.2038947154110307,"self":"https://pharos.nih.gov/idg/api/v1/targets(9172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/publications"},"_namespace":null},{"id":9173,"version":3,"created":1554922756000,"modified":1555038700000,"deprecated":false,"name":"Trichohyalin","accession":"Q07283","gene":"TCHH","description":"Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. 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Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. 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It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. 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The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. 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Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). 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Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3443767136268676,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.06681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.36144067086864,"pubTatorScore":1.6858909490875342,"self":"https://pharos.nih.gov/idg/api/v1/targets(9751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/publications"},"_namespace":null},{"id":9752,"version":2,"created":1554925401000,"modified":1554925405000,"deprecated":false,"name":"Proteasome subunit alpha type-3","accession":"P25788","gene":"PSMA3","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.209805927700631,"antibodyCount":181,"monoclonalCount":13,"pubmedCount":null,"jensenScore":15.830553,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.09413907476266,"pubTatorScore":1.191031608848618,"self":"https://pharos.nih.gov/idg/api/v1/targets(9752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/synonyms"},"_publications":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/publications"},"_namespace":null},{"id":9753,"version":3,"created":1554925406000,"modified":1555038951000,"deprecated":false,"name":"Transmembrane emp24 domain-containing protein 10","accession":"P49755","gene":"TMED10","description":"Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4664381513667615,"antibodyCount":300,"monoclonalCount":6,"pubmedCount":null,"jensenScore":31.937383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":42.937554035513614,"pubTatorScore":1.5816271554628505,"self":"https://pharos.nih.gov/idg/api/v1/targets(9753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":473,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/properties"},"_links":{"count":1210,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/publications"},"_namespace":null},{"id":9754,"version":3,"created":1554925411000,"modified":1555038953000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 41 homolog","accession":"P49754","gene":"VPS41","description":"Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.122278882686007,"antibodyCount":93,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.388702,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.25356086202082,"pubTatorScore":1.369377833890063,"self":"https://pharos.nih.gov/idg/api/v1/targets(9754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/publications"},"_namespace":null},{"id":9755,"version":2,"created":1554925415000,"modified":1554925419000,"deprecated":false,"name":"PDZ domain-containing protein 8","accession":"Q8NEN9","gene":"PDZD8","description":"Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7363964988022866,"antibodyCount":60,"monoclonalCount":9,"pubmedCount":null,"jensenScore":5.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.84470727589008,"pubTatorScore":0.6197887930319512,"self":"https://pharos.nih.gov/idg/api/v1/targets(9755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/publications"},"_namespace":null},{"id":9756,"version":3,"created":1554925419000,"modified":1555038954000,"deprecated":false,"name":"Acyl-coenzyme A thioesterase 2, mitochondrial","accession":"P49753","gene":"ACOT2","description":"Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1995475646360778,"antibodyCount":93,"monoclonalCount":4,"pubmedCount":null,"jensenScore":15.431916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.70987032744543,"pubTatorScore":0.9705534192262603,"self":"https://pharos.nih.gov/idg/api/v1/targets(9756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/publications"},"_namespace":null},{"id":9757,"version":2,"created":1554925422000,"modified":1554925439000,"deprecated":false,"name":"Dual specificity protein kinase CLK1","accession":"P49759","gene":"CLK1","description":"Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.937203365666547,"antibodyCount":156,"monoclonalCount":3,"pubmedCount":null,"jensenScore":87.903235,"patentCount":25929,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.37062835321605,"pubTatorScore":1.789032683122469,"self":"https://pharos.nih.gov/idg/api/v1/targets(9757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/publications"},"_namespace":null},{"id":9758,"version":2,"created":1554925440000,"modified":1554925443000,"deprecated":false,"name":"Proteasome subunit alpha type-2","accession":"P25787","gene":"PSMA2","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8234586398416596,"antibodyCount":245,"monoclonalCount":110,"pubmedCount":null,"jensenScore":5.780531,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.86574454944142,"pubTatorScore":1.1271433645951732,"self":"https://pharos.nih.gov/idg/api/v1/targets(9758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":523,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/links"},"_synonyms":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/publications"},"_namespace":null},{"id":9759,"version":3,"created":1554925444000,"modified":1555038955000,"deprecated":false,"name":"Regulator of G-protein signaling 6","accession":"P49758","gene":"RGS6","description":"Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4499561695416947,"antibodyCount":90,"monoclonalCount":5,"pubmedCount":null,"jensenScore":31.190554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.71615881556692,"pubTatorScore":1.3239216970037058,"self":"https://pharos.nih.gov/idg/api/v1/targets(9759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/links"},"_synonyms":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/publications"},"_namespace":null},{"id":9760,"version":3,"created":1554925449000,"modified":1555038958000,"deprecated":false,"name":"Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha","accession":"P48426","gene":"PIP4K2A","description":"Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.778949521967724,"antibodyCount":244,"monoclonalCount":51,"pubmedCount":null,"jensenScore":57.39335,"patentCount":1480,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":77,"knowledgeAvailability":44.74193747886373,"pubTatorScore":1.6243348888063074,"self":"https://pharos.nih.gov/idg/api/v1/targets(9760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/publications"},"_namespace":null},{"id":9761,"version":3,"created":1554925454000,"modified":1555038960000,"deprecated":false,"name":"Proteasome subunit alpha type-1","accession":"P25786","gene":"PSMA1","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.3637531889424304,"antibodyCount":235,"monoclonalCount":36,"pubmedCount":null,"jensenScore":17.378043,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":45.287023459861835,"pubTatorScore":1.1881786859263397,"self":"https://pharos.nih.gov/idg/api/v1/targets(9761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/publications"},"_namespace":null},{"id":9762,"version":3,"created":1554925460000,"modified":1555038962000,"deprecated":false,"name":"Protein numb homolog","accession":"P49757","gene":"NUMB","description":"Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.600724420049279,"antibodyCount":564,"monoclonalCount":256,"pubmedCount":null,"jensenScore":402.121018,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":47.28640623178152,"pubTatorScore":2.446631457453339,"self":"https://pharos.nih.gov/idg/api/v1/targets(9762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/properties"},"_links":{"count":1227,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/publications"},"_namespace":null},{"id":9763,"version":3,"created":1554925466000,"modified":1555038964000,"deprecated":false,"name":"Dematin","accession":"Q08495","gene":"DMTN","description":"Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7368645460091845,"antibodyCount":158,"monoclonalCount":3,"pubmedCount":null,"jensenScore":56.577755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":35.38906846152416,"pubTatorScore":1.4647913323653932,"self":"https://pharos.nih.gov/idg/api/v1/targets(9763)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/links"},"_synonyms":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/publications"},"_namespace":null},{"id":9764,"version":4,"created":1554925471000,"modified":1555038965000,"deprecated":false,"name":"Liver carboxylesterase 1","accession":"P23141","gene":"CES1","description":"Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. 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Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0738665178089835,"antibodyCount":148,"monoclonalCount":106,"pubmedCount":null,"jensenScore":119.092586,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":41.83996376628568,"pubTatorScore":1.9309810394769116,"self":"https://pharos.nih.gov/idg/api/v1/targets(9814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/publications"},"_namespace":null},{"id":9815,"version":2,"created":1554925890000,"modified":1554925891000,"deprecated":false,"name":"Beta-defensin 108B","accession":"Q8NET1","gene":"DEFB108B","description":"Has antibacterial activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.010995386147214755,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.3,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.66261174669924,"pubTatorScore":0.8846066001802988,"self":"https://pharos.nih.gov/idg/api/v1/targets(9815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/properties"},"_links":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/publications"},"_namespace":null},{"id":9816,"version":3,"created":1554925891000,"modified":1555039008000,"deprecated":false,"name":"Biotin--protein ligase","accession":"P50747","gene":"HLCS","description":"Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3400400875870413,"antibodyCount":86,"monoclonalCount":12,"pubmedCount":null,"jensenScore":223.295569,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.84480289094735,"pubTatorScore":2.4947751108870873,"self":"https://pharos.nih.gov/idg/api/v1/targets(9816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/publications"},"_namespace":null},{"id":9817,"version":2,"created":1554925897000,"modified":1554925899000,"deprecated":false,"name":"Retrotransposon Gag-like protein 9","accession":"Q8NET4","gene":"RTL9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7690958700921147,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.860715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6858482843839785,"self":"https://pharos.nih.gov/idg/api/v1/targets(9817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/properties"},"_links":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/publications"},"_namespace":null},{"id":9818,"version":2,"created":1554925899000,"modified":1554925902000,"deprecated":false,"name":"Caveolae-associated protein 3","accession":"Q969G5","gene":"CAVIN3","description":"Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3979551006675086,"antibodyCount":150,"monoclonalCount":16,"pubmedCount":null,"jensenScore":28.708338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.62271962460745,"self":"https://pharos.nih.gov/idg/api/v1/targets(9818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/publications"},"_namespace":null},{"id":9819,"version":2,"created":1554925903000,"modified":1554925906000,"deprecated":false,"name":"Docosahexaenoic acid omega-hydroxylase CYP4F3","accession":"Q08477","gene":"CYP4F3","description":"Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7068293286950802,"antibodyCount":114,"monoclonalCount":57,"pubmedCount":null,"jensenScore":50.668467,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.247220942938988,"pubTatorScore":3.682380571944615,"self":"https://pharos.nih.gov/idg/api/v1/targets(9819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/publications"},"_namespace":null},{"id":9820,"version":3,"created":1554925907000,"modified":1555039009000,"deprecated":false,"name":"NFAT activation molecule 1","accession":"Q8NET5","gene":"NFAM1","description":"May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.37211722077706094,"antibodyCount":74,"monoclonalCount":8,"pubmedCount":null,"jensenScore":3.318022,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.3411304735338,"pubTatorScore":0.39872797219664635,"self":"https://pharos.nih.gov/idg/api/v1/targets(9820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/publications"},"_namespace":null},{"id":9821,"version":2,"created":1554925910000,"modified":1554925913000,"deprecated":false,"name":"Riboflavin kinase","accession":"Q969G6","gene":"RFK","description":"Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7183962853594612,"antibodyCount":104,"monoclonalCount":2,"pubmedCount":null,"jensenScore":55.587413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.297102027417175,"pubTatorScore":1.2361591801535958,"self":"https://pharos.nih.gov/idg/api/v1/targets(9821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/publications"},"_namespace":null},{"id":9822,"version":2,"created":1554925914000,"modified":1554925916000,"deprecated":false,"name":"Beta-defensin 124","accession":"Q8NES8","gene":"DEFB124","description":"Has antibacterial activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.2668757204167084,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.762338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.389090851216249,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(9822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/properties"},"_links":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/publications"},"_namespace":null},{"id":9823,"version":3,"created":1554925916000,"modified":1555039010000,"deprecated":false,"name":"Ras association domain-containing protein 2","accession":"P50749","gene":"RASSF2","description":"Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.440374501122644,"antibodyCount":124,"monoclonalCount":11,"pubmedCount":null,"jensenScore":31.953888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.34786680911983,"pubTatorScore":1.4642497399533616,"self":"https://pharos.nih.gov/idg/api/v1/targets(9823)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/publications"},"_namespace":null},{"id":9824,"version":2,"created":1554925921000,"modified":1554925925000,"deprecated":false,"name":"Kinetochore-associated protein 1","accession":"P50748","gene":"KNTC1","description":"Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.554700999707938,"antibodyCount":105,"monoclonalCount":50,"pubmedCount":null,"jensenScore":354.990033,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.404643174737934,"pubTatorScore":1.1385764227138597,"self":"https://pharos.nih.gov/idg/api/v1/targets(9824)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/publications"},"_namespace":null},{"id":9825,"version":2,"created":1554925926000,"modified":1554925928000,"deprecated":false,"name":"Zinc finger protein 879","accession":"B4DU55","gene":"ZNF879","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.15503411323135,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9825)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/publications"},"_namespace":null},{"id":9826,"version":3,"created":1554925929000,"modified":1555039012000,"deprecated":false,"name":"Adenylate cyclase type 2","accession":"Q08462","gene":"ADCY2","description":"Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.371655625739674,"antibodyCount":117,"monoclonalCount":9,"pubmedCount":null,"jensenScore":21.428165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":45.607670530043144,"pubTatorScore":2.1160661154210643,"self":"https://pharos.nih.gov/idg/api/v1/targets(9826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/publications"},"_namespace":null},{"id":9827,"version":2,"created":1554925933000,"modified":1554925935000,"deprecated":false,"name":"Fetal and adult testis-expressed transcript protein","accession":"Q969F0","gene":"FATE1","description":"Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3873897898579945,"antibodyCount":201,"monoclonalCount":162,"pubmedCount":null,"jensenScore":22.453332,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.299048714966984,"pubTatorScore":0.7659167691498038,"self":"https://pharos.nih.gov/idg/api/v1/targets(9827)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/properties"},"_links":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/publications"},"_namespace":null},{"id":9828,"version":2,"created":1554925936000,"modified":1554925936000,"deprecated":false,"name":"Immunoglobulin gamma-1 heavy chain","accession":"P0DOX5","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9828)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/publications"},"_namespace":null},{"id":9829,"version":2,"created":1554925936000,"modified":1554925936000,"deprecated":false,"name":"Immunoglobulin mu heavy chain","accession":"P0DOX6","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/publications"},"_namespace":null},{"id":9830,"version":3,"created":1554925936000,"modified":1555039013000,"deprecated":false,"name":"Protein naked cuticle homolog 2","accession":"Q969F2","gene":"NKD2","description":"Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2984303744709966,"antibodyCount":121,"monoclonalCount":5,"pubmedCount":null,"jensenScore":19.722532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":27.897171764592404,"pubTatorScore":1.1934636332718036,"self":"https://pharos.nih.gov/idg/api/v1/targets(9830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/publications"},"_namespace":null},{"id":9831,"version":4,"created":1554925939000,"modified":1555039015000,"deprecated":false,"name":"Cyclin-dependent kinase 9","accession":"P50750","gene":"CDK9","description":"Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.0154456847299227,"antibodyCount":372,"monoclonalCount":68,"pubmedCount":null,"jensenScore":918.281001,"patentCount":62312,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":50.290220979822315,"pubTatorScore":2.569604758295301,"self":"https://pharos.nih.gov/idg/api/v1/targets(9831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":757,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/properties"},"_links":{"count":1432,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/synonyms"},"_publications":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/publications"},"_namespace":null},{"id":9832,"version":2,"created":1554925997000,"modified":1554925997000,"deprecated":false,"name":"Immunoglobulin kappa light chain","accession":"P0DOX7","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/publications"},"_namespace":null},{"id":9833,"version":2,"created":1554925997000,"modified":1554925999000,"deprecated":false,"name":"General transcription factor 3C polypeptide 6","accession":"Q969F1","gene":"GTF3C6","description":"Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.34678748579036184,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.360294,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.680744969582552,"pubTatorScore":-0.3467874862246563,"self":"https://pharos.nih.gov/idg/api/v1/targets(9833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/publications"},"_namespace":null},{"id":9834,"version":2,"created":1554926000000,"modified":1554926000000,"deprecated":false,"name":"Immunoglobulin lambda-1 light chain","accession":"P0DOX8","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/publications"},"_namespace":null},{"id":9835,"version":2,"created":1554926000000,"modified":1554926002000,"deprecated":false,"name":"Glutamate-rich protein 6B","accession":"Q5W0A0","gene":"ERICH6B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.88079032854979,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/properties"},"_links":{"count":645,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/publications"},"_namespace":null},{"id":9836,"version":3,"created":1554926003000,"modified":1555039018000,"deprecated":false,"name":"Twinfilin-2","accession":"Q6IBS0","gene":"TWF2","description":"Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2487903578873696,"antibodyCount":162,"monoclonalCount":6,"pubmedCount":null,"jensenScore":17.754055,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":34.03366648544167,"pubTatorScore":0.8419848045901139,"self":"https://pharos.nih.gov/idg/api/v1/targets(9836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/publications"},"_namespace":null},{"id":9837,"version":3,"created":1554926006000,"modified":1554926051000,"deprecated":false,"name":"KiSS-1 receptor","accession":"Q969F8","gene":"KISS1R","description":"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.451581097528305,"antibodyCount":223,"monoclonalCount":1,"pubmedCount":null,"jensenScore":266.496529,"patentCount":15461,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.03449363003225,"pubTatorScore":2.3313304836166817,"self":"https://pharos.nih.gov/idg/api/v1/targets(9837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/publications"},"_namespace":null},{"id":9838,"version":2,"created":1554926052000,"modified":1554926056000,"deprecated":false,"name":"Hermansky-Pudlak syndrome 3 protein","accession":"Q969F9","gene":"HPS3","description":"Involved in early stages of melanosome biogenesis and maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2480706343727457,"antibodyCount":141,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.434481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.06857136684026,"pubTatorScore":1.2595028777308703,"self":"https://pharos.nih.gov/idg/api/v1/targets(9838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/publications"},"_namespace":null},{"id":9839,"version":2,"created":1554926057000,"modified":1554926060000,"deprecated":false,"name":"Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe","accession":"Q8NES3","gene":"LFNG","description":"Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.505351954841353,"antibodyCount":220,"monoclonalCount":99,"pubmedCount":null,"jensenScore":29.757306,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.15407474535347,"pubTatorScore":1.3562162927853136,"self":"https://pharos.nih.gov/idg/api/v1/targets(9839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/publications"},"_namespace":null},{"id":9840,"version":2,"created":1554926061000,"modified":1554926062000,"deprecated":false,"name":"Chimeric ERCC6-PGBD3 protein","accession":"P0DP91","gene":"ERCC6","description":"Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.317763740386917,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":361.474783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.962018690949584,"pubTatorScore":2.274750976766077,"self":"https://pharos.nih.gov/idg/api/v1/targets(9840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/properties"},"_links":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/synonyms"},"_publications":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/publications"},"_namespace":null},{"id":9841,"version":2,"created":1554926063000,"modified":1554926063000,"deprecated":false,"name":"Immunoglobulin alpha-2 heavy chain","accession":"P0DOX2","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/publications"},"_namespace":null},{"id":9842,"version":2,"created":1554926063000,"modified":1554926063000,"deprecated":false,"name":"Immunoglobulin delta heavy chain","accession":"P0DOX3","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum is below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:11282392, PubMed:10702483, PubMed:16895553).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/publications"},"_namespace":null},{"id":9843,"version":2,"created":1554926064000,"modified":1554926064000,"deprecated":false,"name":"Immunoglobulin epsilon heavy chain","accession":"P0DOX4","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9843)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/publications"},"_namespace":null},{"id":9844,"version":2,"created":1554926064000,"modified":1554926067000,"deprecated":false,"name":"Neuronal PAS domain-containing protein 3","accession":"Q8IXF0","gene":"NPAS3","description":"May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4942158720812069,"antibodyCount":112,"monoclonalCount":2,"pubmedCount":null,"jensenScore":32.430932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.69102639187412,"pubTatorScore":1.5259288820667398,"self":"https://pharos.nih.gov/idg/api/v1/targets(9844)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/publications"},"_namespace":null},{"id":9845,"version":3,"created":1554926068000,"modified":1555039019000,"deprecated":false,"name":"Lysophosphatidylcholine acyltransferase 1","accession":"Q8NF37","gene":"LPCAT1","description":"Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). 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VCPIP1 is also required, but not its deubiquitinating activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.23408320494763177,"antibodyCount":73,"monoclonalCount":43,"pubmedCount":null,"jensenScore":0.708333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":29.876094119867442,"pubTatorScore":0.6812412373755872,"self":"https://pharos.nih.gov/idg/api/v1/targets(9878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/publications"},"_namespace":null},{"id":9879,"version":2,"created":1554926717000,"modified":1554926720000,"deprecated":false,"name":"CXXC-type zinc finger protein 5","accession":"Q7LFL8","gene":"CXXC5","description":"May indirectly participate in activation of the NF-kappa-B and MAPK pathways. 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May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0790053055666924,"antibodyCount":97,"monoclonalCount":3,"pubmedCount":null,"jensenScore":121.761838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.383238686133694,"pubTatorScore":1.436480218111925,"self":"https://pharos.nih.gov/idg/api/v1/targets(9879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/publications"},"_namespace":null},{"id":9880,"version":2,"created":1554926721000,"modified":1554926725000,"deprecated":false,"name":"Retinoic acid-induced protein 3","accession":"Q8NFJ5","gene":"GPRC5A","description":"Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.5169174624473412,"antibodyCount":294,"monoclonalCount":19,"pubmedCount":null,"jensenScore":37.729181,"patentCount":13444,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.21255177425229,"pubTatorScore":1.465224007455352,"self":"https://pharos.nih.gov/idg/api/v1/targets(9880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/publications"},"_namespace":null},{"id":9881,"version":2,"created":1554926726000,"modified":1554926729000,"deprecated":false,"name":"Prokineticin receptor 2","accession":"Q8NFJ6","gene":"PROKR2","description":"Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.683314811205036,"antibodyCount":155,"monoclonalCount":0,"pubmedCount":null,"jensenScore":49.290041,"patentCount":14366,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.24229647075051,"pubTatorScore":1.8382486508225022,"self":"https://pharos.nih.gov/idg/api/v1/targets(9881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/properties"},"_links":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/publications"},"_namespace":null},{"id":9882,"version":3,"created":1554926729000,"modified":1555039043000,"deprecated":false,"name":"Bardet-Biedl syndrome 1 protein","accession":"Q8NFJ9","gene":"BBS1","description":"The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7903732092261289,"antibodyCount":75,"monoclonalCount":4,"pubmedCount":null,"jensenScore":57.772652,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":41.58250570760431,"pubTatorScore":1.7094621785634398,"self":"https://pharos.nih.gov/idg/api/v1/targets(9882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/publications"},"_namespace":null},{"id":9883,"version":2,"created":1554926734000,"modified":1554926737000,"deprecated":false,"name":"Class E basic helix-loop-helix protein 22","accession":"Q8NFJ8","gene":"BHLHE22","description":"Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.0288587291620606,"antibodyCount":108,"monoclonalCount":2,"pubmedCount":null,"jensenScore":950.672071,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.605043665996682,"pubTatorScore":1.1010811379122978,"self":"https://pharos.nih.gov/idg/api/v1/targets(9883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/publications"},"_namespace":null},{"id":9884,"version":2,"created":1554926738000,"modified":1554926740000,"deprecated":false,"name":"Leukocyte immunoglobulin-like receptor subfamily A member 1","accession":"O75019","gene":"LILRA1","description":"May act as receptor for class I MHC antigens.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5503252021852654,"antibodyCount":105,"monoclonalCount":24,"pubmedCount":null,"jensenScore":2.338328,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.969986678340042,"pubTatorScore":0.6368220641799052,"self":"https://pharos.nih.gov/idg/api/v1/targets(9884)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/properties"},"_links":{"count":700,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/publications"},"_namespace":null},{"id":9885,"version":2,"created":1554926741000,"modified":1554926743000,"deprecated":false,"name":"Uncharacterized protein C9orf172","accession":"C9J069","gene":"AJM1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9885)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/publications"},"_namespace":null},{"id":9886,"version":2,"created":1554926743000,"modified":1554926743000,"deprecated":false,"name":"Immunoglobulin heavy variable 1-8","accession":"P0DP01","gene":"IGHV1-8","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.7358408658180186,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9886)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/publications"},"_namespace":null},{"id":9887,"version":2,"created":1554926744000,"modified":1554926744000,"deprecated":false,"name":"Immunoglobulin heavy variable 3-30-3","accession":"P0DP02","gene":"IGHV3-30-3","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9887)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/publications"},"_namespace":null},{"id":9888,"version":2,"created":1554926744000,"modified":1554926748000,"deprecated":false,"name":"Annexin A3","accession":"P12429","gene":"ANXA3","description":"Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0146193380924027,"antibodyCount":354,"monoclonalCount":71,"pubmedCount":null,"jensenScore":104.568048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.48393626317517,"pubTatorScore":1.9883098126381322,"self":"https://pharos.nih.gov/idg/api/v1/targets(9888)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/publications"},"_namespace":null},{"id":9889,"version":2,"created":1554926749000,"modified":1554926749000,"deprecated":false,"name":"Immunoglobulin heavy variable 3-30-5","accession":"P0DP03","gene":"IGHV3-30-5","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9889)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/publications"},"_namespace":null},{"id":9890,"version":3,"created":1554926749000,"modified":1555039045000,"deprecated":false,"name":"Low affinity immunoglobulin gamma Fc region receptor III-B","accession":"O75015","gene":"FCGR3B","description":"Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.2365794943375086,"antibodyCount":441,"monoclonalCount":397,"pubmedCount":null,"jensenScore":1624.900466,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":23.43858639925446,"pubTatorScore":2.3179849607048575,"self":"https://pharos.nih.gov/idg/api/v1/targets(9890)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/publications"},"_namespace":null},{"id":9891,"version":2,"created":1554926755000,"modified":1554926757000,"deprecated":false,"name":"Protein crumbs homolog 2","accession":"Q5IJ48","gene":"CRB2","description":"Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4485227984776023,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":30.864919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.682254289516457,"pubTatorScore":1.3013387561173033,"self":"https://pharos.nih.gov/idg/api/v1/targets(9891)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/publications"},"_namespace":null},{"id":9892,"version":2,"created":1554926758000,"modified":1554926763000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DRB1-4 beta chain","accession":"P13760","gene":"HLA-DRB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. 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Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2282876131197216,"antibodyCount":267,"monoclonalCount":45,"pubmedCount":null,"jensenScore":176.652593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":44.21507917397478,"pubTatorScore":2.1587733995941654,"self":"https://pharos.nih.gov/idg/api/v1/targets(9961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/publications"},"_namespace":null},{"id":9962,"version":2,"created":1554927055000,"modified":1554927058000,"deprecated":false,"name":"N-alpha-acetyltransferase 25, NatB auxiliary subunit","accession":"Q14CX7","gene":"NAA25","description":"Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. 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However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.9537858717936727,"antibodyCount":741,"monoclonalCount":279,"pubmedCount":null,"jensenScore":880.998132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":55.45419973305048,"pubTatorScore":2.7810836615921857,"self":"https://pharos.nih.gov/idg/api/v1/targets(9965)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":709,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/properties"},"_links":{"count":1391,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/synonyms"},"_publications":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/publications"},"_namespace":null},{"id":9966,"version":2,"created":1554927077000,"modified":1554927080000,"deprecated":false,"name":"Adenylate cyclase type 4","accession":"Q8NFM4","gene":"ADCY4","description":"Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0460331137250125,"antibodyCount":156,"monoclonalCount":0,"pubmedCount":null,"jensenScore":107.559948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.51246220111338,"pubTatorScore":1.651074410129058,"self":"https://pharos.nih.gov/idg/api/v1/targets(9966)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":453,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/publications"},"_namespace":null},{"id":9967,"version":2,"created":1554927081000,"modified":1554927081000,"deprecated":false,"name":"Putative uncharacterized protein LOC100996504","accession":"I3L1I5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9967)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/properties"},"_links":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/publications"},"_namespace":null},{"id":9968,"version":2,"created":1554927081000,"modified":1554927081000,"deprecated":false,"name":"Putative coiled-coil domain-containing protein 144C","accession":"Q8IYA2","gene":"CCDC144CP","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.745138091704004,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9968)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/properties"},"_links":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/publications"},"_namespace":null},{"id":9969,"version":3,"created":1554927081000,"modified":1555039095000,"deprecated":false,"name":"Proteasome subunit beta type-2","accession":"P49721","gene":"PSMB2","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.7439013844110007,"antibodyCount":188,"monoclonalCount":38,"pubmedCount":null,"jensenScore":4.716269,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":46.6991949737773,"pubTatorScore":0.35220876800672424,"self":"https://pharos.nih.gov/idg/api/v1/targets(9969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":607,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/properties"},"_links":{"count":1136,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/publications"},"_namespace":null},{"id":9970,"version":3,"created":1554927100000,"modified":1555039098000,"deprecated":false,"name":"Proteasome subunit beta type-3","accession":"P49720","gene":"PSMB3","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5775356411247482,"antibodyCount":81,"monoclonalCount":7,"pubmedCount":null,"jensenScore":2.935869,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":42.213939970933666,"pubTatorScore":0.8052410873357109,"self":"https://pharos.nih.gov/idg/api/v1/targets(9970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/properties"},"_links":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/publications"},"_namespace":null},{"id":9971,"version":3,"created":1554927102000,"modified":1555039098000,"deprecated":false,"name":"Interleukin-17 receptor D","accession":"Q8NFM7","gene":"IL17RD","description":"Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. 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TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7477024446481382,"antibodyCount":325,"monoclonalCount":100,"pubmedCount":null,"jensenScore":44.78134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.161385867276586,"pubTatorScore":1.93814966674101,"self":"https://pharos.nih.gov/idg/api/v1/targets(9980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/publications"},"_namespace":null},{"id":9981,"version":2,"created":1554927779000,"modified":1554927782000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DO beta chain","accession":"P13765","gene":"HLA-DOB","description":"Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. 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Does not act as an allosteric activator of the cholera toxin catalytic subunit.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.528539299106156,"antibodyCount":311,"monoclonalCount":111,"pubmedCount":null,"jensenScore":37.698628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.594103819909606,"pubTatorScore":1.3758667065676011,"self":"https://pharos.nih.gov/idg/api/v1/targets(9983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/properties"},"_links":{"count":1138,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/publications"},"_namespace":null},{"id":9984,"version":3,"created":1554927791000,"modified":1555039108000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 2","accession":"P36404","gene":"ARL2","description":"Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). 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In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(9985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2689,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/properties"},"_links":{"count":1238,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/synonyms"},"_publications":{"count":2531,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/publications"},"_namespace":null},{"id":9986,"version":2,"created":1554927809000,"modified":1554927810000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DR beta 4 chain","accession":"P13762","gene":"HLA-DRB4","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. 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In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.223161699078588,"pubTatorScore":3.3773864050688718,"self":"https://pharos.nih.gov/idg/api/v1/targets(9986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/properties"},"_links":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/publications"},"_namespace":null},{"id":9987,"version":2,"created":1554927810000,"modified":1554927813000,"deprecated":false,"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7","accession":"Q8NFL0","gene":"B3GNT7","description":"May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. 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The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(9988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2684,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/properties"},"_links":{"count":1122,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/links"},"_synonyms":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/synonyms"},"_publications":{"count":2548,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/publications"},"_namespace":null},{"id":9989,"version":3,"created":1554927829000,"modified":1555039109000,"deprecated":false,"name":"Transport and Golgi organization protein 2 homolog","accession":"Q6ICL3","gene":"TANGO2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6012837673378828,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.127473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.180871488898934,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(9989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/publications"},"_namespace":null},{"id":9990,"version":2,"created":1554927832000,"modified":1554927835000,"deprecated":false,"name":"Probable palmitoyltransferase ZDHHC20","accession":"Q5W0Z9","gene":"ZDHHC20","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.3891660793701459,"antibodyCount":139,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.403743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.316255960615496,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(9990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/publications"},"_namespace":null},{"id":9991,"version":2,"created":1554927835000,"modified":1554927840000,"deprecated":false,"name":"Transcriptional repressor CTCF","accession":"P49711","gene":"CTCF","description":"Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.8772600070376426,"antibodyCount":284,"monoclonalCount":61,"pubmedCount":null,"jensenScore":746.514692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.57453990493493,"pubTatorScore":2.718560115398199,"self":"https://pharos.nih.gov/idg/api/v1/targets(9991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":652,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/properties"},"_links":{"count":1303,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/synonyms"},"_publications":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/publications"},"_namespace":null},{"id":9992,"version":2,"created":1554927841000,"modified":1554927843000,"deprecated":false,"name":"Solute carrier family 35 member E4","accession":"Q6ICL7","gene":"SLC35E4","description":"Putative transporter.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.23640511477795,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/publications"},"_namespace":null},{"id":9993,"version":3,"created":1554927844000,"modified":1555039110000,"deprecated":false,"name":"Coagulation factor XIII A chain","accession":"P00488","gene":"F13A1","description":"Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3158712768141467,"antibodyCount":726,"monoclonalCount":423,"pubmedCount":null,"jensenScore":200.753567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.178849926493534,"pubTatorScore":2.701786253401274,"self":"https://pharos.nih.gov/idg/api/v1/targets(9993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":614,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/synonyms"},"_publications":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/publications"},"_namespace":null},{"id":9994,"version":2,"created":1554927875000,"modified":1554927878000,"deprecated":false,"name":"CCAAT/enhancer-binding protein delta","accession":"P49716","gene":"CEBPD","description":"Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.490290872272222,"antibodyCount":179,"monoclonalCount":2,"pubmedCount":null,"jensenScore":299.92253,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.064747256367355,"pubTatorScore":2.266846538439986,"self":"https://pharos.nih.gov/idg/api/v1/targets(9994)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/publications"},"_namespace":null},{"id":9995,"version":2,"created":1554927879000,"modified":1554927884000,"deprecated":false,"name":"CCAAT/enhancer-binding protein alpha","accession":"P49715","gene":"CEBPA","description":"Isoform 4: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.943930253618226,"antibodyCount":518,"monoclonalCount":86,"pubmedCount":null,"jensenScore":846.319965,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.55163136539561,"pubTatorScore":3.02750590893941,"self":"https://pharos.nih.gov/idg/api/v1/targets(9995)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/properties"},"_links":{"count":1212,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/synonyms"},"_publications":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/publications"},"_namespace":null},{"id":9996,"version":3,"created":1554927886000,"modified":1555039112000,"deprecated":false,"name":"Putative oxidoreductase GLYR1","accession":"Q49A26","gene":"GLYR1","description":"Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.7362510531843296,"antibodyCount":63,"monoclonalCount":6,"pubmedCount":null,"jensenScore":55.847459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.938514709836966,"pubTatorScore":0.9827735930047439,"self":"https://pharos.nih.gov/idg/api/v1/targets(9996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/publications"},"_namespace":null},{"id":9997,"version":2,"created":1554927890000,"modified":1554927892000,"deprecated":false,"name":"Polypeptide N-acetylgalactosaminyltransferase-like 6","accession":"Q49A17","gene":"GALNTL6","description":"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.1720512788411941,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.56456,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.89780043024031,"pubTatorScore":0.09828645387847472,"self":"https://pharos.nih.gov/idg/api/v1/targets(9997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/publications"},"_namespace":null},{"id":9998,"version":3,"created":1554927893000,"modified":1555039114000,"deprecated":false,"name":"Ornithine carbamoyltransferase, mitochondrial","accession":"P00480","gene":"OTC","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.217520925963561,"antibodyCount":480,"monoclonalCount":319,"pubmedCount":null,"jensenScore":151.6874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":33.442684356979605,"pubTatorScore":2.972655468322856,"self":"https://pharos.nih.gov/idg/api/v1/targets(9998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/properties"},"_links":{"count":808,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/publications"},"_namespace":null},{"id":9999,"version":2,"created":1554927899000,"modified":1554927901000,"deprecated":false,"name":"Kelch repeat and BTB domain-containing protein 13","accession":"C9JR72","gene":"KBTBD13","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4687691742747739,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.858466,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.721500512556156,"pubTatorScore":0.6276583946802454,"self":"https://pharos.nih.gov/idg/api/v1/targets(9999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/properties"},"_links":{"count":593,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/publications"},"_namespace":null},{"id":10000,"version":3,"created":1554927901000,"modified":1555039115000,"deprecated":false,"name":"Calmodulin-1","accession":"P0DP23","gene":"CALM3","description":"Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. 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Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.590929562440972,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5859.505004,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.885261128818016,"pubTatorScore":2.785312311942851,"self":"https://pharos.nih.gov/idg/api/v1/targets(10000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":658,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/properties"},"_links":{"count":1636,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/links"},"_synonyms":{"count":527,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/synonyms"},"_publications":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/publications"},"_namespace":null}]}
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Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-2.2845666241309295,"antibodyCount":673,"monoclonalCount":200,"pubmedCount":null,"jensenScore":142.907112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":47.91798993762773,"pubTatorScore":2.440976209992174,"self":"https://pharos.nih.gov/idg/api/v1/targets(10075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":706,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/properties"},"_links":{"count":1878,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/synonyms"},"_publications":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/publications"},"_namespace":null},{"id":10076,"version":3,"created":1554928221000,"modified":1555039159000,"deprecated":false,"name":"Lethal(3)malignant brain tumor-like protein 2","accession":"Q969R5","gene":"L3MBTL2","description":"Putative Polycomb group (PcG) protein. 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Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). 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The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.195316846946816,"antibodyCount":1167,"monoclonalCount":410,"pubmedCount":null,"jensenScore":132.541228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":51.50072590927084,"pubTatorScore":2.903967779097315,"self":"https://pharos.nih.gov/idg/api/v1/targets(10081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1469,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/properties"},"_links":{"count":2066,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/links"},"_synonyms":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/synonyms"},"_publications":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/publications"},"_namespace":null},{"id":10082,"version":2,"created":1554928260000,"modified":1554928264000,"deprecated":false,"name":"Importin-8","accession":"O15397","gene":"IPO8","description":"Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 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Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6709669998736605,"antibodyCount":87,"monoclonalCount":11,"pubmedCount":null,"jensenScore":46.349379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":0.0,"pubTatorScore":1.1749638160546212,"self":"https://pharos.nih.gov/idg/api/v1/targets(10116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/publications"},"_namespace":null},{"id":10117,"version":3,"created":1554928374000,"modified":1555039179000,"deprecated":false,"name":"Endoplasmic reticulum-Golgi intermediate compartment protein 1","accession":"Q969X5","gene":"ERGIC1","description":"Possible role in transport between endoplasmic reticulum and Golgi.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0997956940073033,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.057539,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.13883828235986,"pubTatorScore":0.04792368195730733,"self":"https://pharos.nih.gov/idg/api/v1/targets(10117)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/publications"},"_namespace":null},{"id":10118,"version":3,"created":1554928379000,"modified":1555039180000,"deprecated":false,"name":"DNA-directed RNA polymerase III subunit RPC7","accession":"O15318","gene":"POLR3G","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1769177256129648,"antibodyCount":85,"monoclonalCount":3,"pubmedCount":null,"jensenScore":14.159892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.92806896139975,"pubTatorScore":0.7323327934666588,"self":"https://pharos.nih.gov/idg/api/v1/targets(10118)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/publications"},"_namespace":null},{"id":10119,"version":3,"created":1554928383000,"modified":1555039181000,"deprecated":false,"name":"DNA repair protein RAD51 homolog 2","accession":"O15315","gene":"RAD51B","description":"Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9456420822101401,"antibodyCount":171,"monoclonalCount":51,"pubmedCount":null,"jensenScore":84.795957,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.89443439861342,"pubTatorScore":1.8467557755408657,"self":"https://pharos.nih.gov/idg/api/v1/targets(10119)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":477,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/properties"},"_links":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/publications"},"_namespace":null},{"id":10120,"version":2,"created":1554928388000,"modified":1554928391000,"deprecated":false,"name":"Structure-specific endonuclease subunit SLX4","accession":"Q8IY92","gene":"SLX4","description":"Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.687942874268222,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":61.732779,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.6984828820373,"pubTatorScore":1.625631622425185,"self":"https://pharos.nih.gov/idg/api/v1/targets(10120)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/publications"},"_namespace":null},{"id":10121,"version":3,"created":1554928392000,"modified":1555039183000,"deprecated":false,"name":"Transmembrane protein 183A","accession":"Q8IXX5","gene":"TMEM183A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.049797469484342556,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.467533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.489395428757657,"pubTatorScore":0.3473300153169504,"self":"https://pharos.nih.gov/idg/api/v1/targets(10121)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/publications"},"_namespace":null},{"id":10122,"version":2,"created":1554928395000,"modified":1554928398000,"deprecated":false,"name":"Transmembrane protein 192","accession":"Q8IY95","gene":"TMEM192","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5513919097592981,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.044257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.320772933624156,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(10122)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/publications"},"_namespace":null},{"id":10123,"version":3,"created":1554928399000,"modified":1555039184000,"deprecated":false,"name":"Postacrosomal sheath WW domain-binding protein","accession":"Q6ICG8","gene":"WBP2NL","description":"May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9615849147809674,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":89.432168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":21.07298902292309,"pubTatorScore":1.6720386235212576,"self":"https://pharos.nih.gov/idg/api/v1/targets(10123)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/properties"},"_links":{"count":733,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/publications"},"_namespace":null},{"id":10124,"version":2,"created":1554928401000,"modified":1554928407000,"deprecated":false,"name":"Delta-aminolevulinic acid dehydratase","accession":"P13716","gene":"ALAD","description":"Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0202422675251954,"antibodyCount":166,"monoclonalCount":7,"pubmedCount":null,"jensenScore":1068.562629,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.76361702420024,"pubTatorScore":2.894803662206195,"self":"https://pharos.nih.gov/idg/api/v1/targets(10124)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/publications"},"_namespace":null},{"id":10125,"version":3,"created":1554928408000,"modified":1555039185000,"deprecated":false,"name":"Palmitoyltransferase ZDHHC16","accession":"Q969W1","gene":"ZDHHC16","description":"Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4890204838099633,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.19994158977682,"pubTatorScore":1.2844307112837665,"self":"https://pharos.nih.gov/idg/api/v1/targets(10125)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/publications"},"_namespace":null},{"id":10126,"version":2,"created":1554928412000,"modified":1554928412000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-8","accession":"P01709","gene":"IGLV2-8","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.138721289330153,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(10126)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/publications"},"_namespace":null},{"id":10127,"version":3,"created":1554928412000,"modified":1555039186000,"deprecated":false,"name":"Serine palmitoyltransferase small subunit A","accession":"Q969W0","gene":"SPTSSA","description":"Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.35856932111570794,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.200534,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.045156427748775,"pubTatorScore":0.22617003740008312,"self":"https://pharos.nih.gov/idg/api/v1/targets(10127)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/publications"},"_namespace":null},{"id":10128,"version":2,"created":1554928415000,"modified":1554928417000,"deprecated":false,"name":"Protein FAM104A","accession":"Q969W3","gene":"FAM104A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.581691998746727,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10128)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/publications"},"_namespace":null},{"id":10129,"version":2,"created":1554928418000,"modified":1554928420000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-11","accession":"P01706","gene":"IGLV2-11","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.4303302292068714,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10129)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/properties"},"_links":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/publications"},"_namespace":null},{"id":10130,"version":2,"created":1554928421000,"modified":1554928422000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-23","accession":"P01705","gene":"IGLV2-23","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.5239746753089545,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10130)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/properties"},"_links":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/publications"},"_namespace":null},{"id":10131,"version":2,"created":1554928422000,"modified":1554928423000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-14","accession":"P01704","gene":"IGLV2-14","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.991284812390269,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10131)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/properties"},"_links":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/publications"},"_namespace":null},{"id":10132,"version":2,"created":1554928424000,"modified":1554928425000,"deprecated":false,"name":"Immunoglobulin lambda variable 1-40","accession":"P01703","gene":"IGLV1-40","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.605291313050428,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10132)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/properties"},"_links":{"count":504,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/publications"},"_namespace":null},{"id":10133,"version":3,"created":1554928425000,"modified":1555039187000,"deprecated":false,"name":"B box and SPRY domain-containing protein","accession":"Q5W0U4","gene":"BSPRY","description":"May regulate epithelial calcium transport by inhibiting TRPV5 activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3127894657031628,"antibodyCount":41,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.241612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":28.37661650212082,"pubTatorScore":0.4756711883244297,"self":"https://pharos.nih.gov/idg/api/v1/targets(10133)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/publications"},"_namespace":null},{"id":10134,"version":2,"created":1554928429000,"modified":1554928432000,"deprecated":false,"name":"Protein TMEPAI","accession":"Q969W9","gene":"PMEPA1","description":"Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. 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Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3552705011391046,"antibodyCount":90,"monoclonalCount":22,"pubmedCount":null,"jensenScore":24.764944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.244645794818304,"pubTatorScore":1.4028348743444177,"self":"https://pharos.nih.gov/idg/api/v1/targets(10134)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/publications"},"_namespace":null},{"id":10135,"version":2,"created":1554928433000,"modified":1554928434000,"deprecated":false,"name":"Immunoglobulin lambda variable 1-51","accession":"P01701","gene":"IGLV1-51","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, 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Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). 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Forms filamentous polymers in the walls of ciliary and flagellar microtubules.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9129457112947499,"antibodyCount":109,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.424329,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.99217754429265,"pubTatorScore":0.5503739090642426,"self":"https://pharos.nih.gov/idg/api/v1/targets(10162)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/properties"},"_links":{"count":727,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/publications"},"_namespace":null},{"id":10163,"version":2,"created":1554928521000,"modified":1554928522000,"deprecated":false,"name":"Putative dispanin subfamily A member 2d","accession":"C9JQL5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.932557529051246,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":151.247483,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10163)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/properties"},"_links":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/links"},"_synonyms":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/publications"},"_namespace":null},{"id":10164,"version":3,"created":1554928522000,"modified":1555039198000,"deprecated":false,"name":"T-cell surface glycoprotein CD4","accession":"P01730","gene":"CD4","description":"(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.6276183071612,"antibodyCount":4422,"monoclonalCount":3807,"pubmedCount":null,"jensenScore":407.909257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":46.00758150519637,"pubTatorScore":4.540309834110986,"self":"https://pharos.nih.gov/idg/api/v1/targets(10164)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/links"},"_synonyms":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/synonyms"},"_publications":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/publications"},"_namespace":null},{"id":10165,"version":3,"created":1554928531000,"modified":1555039201000,"deprecated":false,"name":"Nicalin","accession":"Q969V3","gene":"NCLN","description":"May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0283854779743529,"antibodyCount":94,"monoclonalCount":6,"pubmedCount":null,"jensenScore":11.276094,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.238104696915755,"pubTatorScore":0.7061485604848146,"self":"https://pharos.nih.gov/idg/api/v1/targets(10165)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/publications"},"_namespace":null},{"id":10166,"version":2,"created":1554928535000,"modified":1554928535000,"deprecated":false,"name":"Uncharacterized protein FLJ76381","accession":"Q8NFD4","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10166)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/publications"},"_namespace":null},{"id":10167,"version":3,"created":1554928535000,"modified":1555039202000,"deprecated":false,"name":"MKL/myocardin-like protein 1","accession":"Q969V6","gene":"MKL1","description":"Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5170435654789096,"antibodyCount":199,"monoclonalCount":38,"pubmedCount":null,"jensenScore":351.752405,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.29775247089428,"pubTatorScore":1.946722175712949,"self":"https://pharos.nih.gov/idg/api/v1/targets(10167)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/synonyms"},"_publications":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/publications"},"_namespace":null},{"id":10168,"version":2,"created":1554928539000,"modified":1554928542000,"deprecated":false,"name":"Ankyrin repeat and protein kinase domain-containing protein 1","accession":"Q8NFD2","gene":"ANKK1","description":null,"idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.0801131989233697,"antibodyCount":75,"monoclonalCount":0,"pubmedCount":null,"jensenScore":103.732022,"patentCount":1555,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.643103278567576,"pubTatorScore":2.051606931123645,"self":"https://pharos.nih.gov/idg/api/v1/targets(10168)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/synonyms"},"_publications":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/publications"},"_namespace":null},{"id":10169,"version":2,"created":1554928543000,"modified":1554928546000,"deprecated":false,"name":"Mitochondrial ubiquitin ligase activator of NFKB 1","accession":"Q969V5","gene":"MUL1","description":"Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitchondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitchondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.417104090427629,"antibodyCount":150,"monoclonalCount":7,"pubmedCount":null,"jensenScore":245.784311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.37532103407905,"pubTatorScore":1.665257034743187,"self":"https://pharos.nih.gov/idg/api/v1/targets(10169)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/publications"},"_namespace":null},{"id":10170,"version":2,"created":1554928547000,"modified":1554928549000,"deprecated":false,"name":"Lamin tail domain-containing protein 2","accession":"Q8IXW0","gene":"LMNTD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.907430140987692,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10170)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/publications"},"_namespace":null},{"id":10171,"version":2,"created":1554928549000,"modified":1554928553000,"deprecated":false,"name":"Biorientation of chromosomes in cell division protein 1-like 1","accession":"Q8NFC6","gene":"BOD1L1","description":"Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2218487496163564,"antibodyCount":22,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.861111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.969643287574286,"pubTatorScore":0.16136800223497488,"self":"https://pharos.nih.gov/idg/api/v1/targets(10171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/publications"},"_namespace":null},{"id":10172,"version":2,"created":1554928554000,"modified":1554928558000,"deprecated":false,"name":"Tumor protein p73","accession":"O15350","gene":"TP73","description":"Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9283234110304306,"antibodyCount":708,"monoclonalCount":273,"pubmedCount":null,"jensenScore":82.594326,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.94600053007851,"pubTatorScore":2.90574915693978,"self":"https://pharos.nih.gov/idg/api/v1/targets(10172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":909,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/properties"},"_links":{"count":1357,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/links"},"_synonyms":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/synonyms"},"_publications":{"count":545,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/publications"},"_namespace":null},{"id":10173,"version":2,"created":1554928561000,"modified":1554928562000,"deprecated":false,"name":"Uncharacterized protein C2orf91","accession":"Q6ZV80","gene":"C2orf91","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/properties"},"_links":{"count":582,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/publications"},"_namespace":null},{"id":10174,"version":2,"created":1554928562000,"modified":1554928565000,"deprecated":false,"name":"Forkhead box protein N1","accession":"O15353","gene":"FOXN1","description":"Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. 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Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.302057012615302,"antibodyCount":204,"monoclonalCount":5,"pubmedCount":null,"jensenScore":196.381041,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.606973480773778,"pubTatorScore":1.7445695289032133,"self":"https://pharos.nih.gov/idg/api/v1/targets(10174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/properties"},"_links":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/publications"},"_namespace":null},{"id":10175,"version":3,"created":1554928566000,"modified":1555039204000,"deprecated":false,"name":"Prosaposin receptor GPR37","accession":"O15354","gene":"GPR37","description":"Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.527391704000663,"antibodyCount":191,"monoclonalCount":23,"pubmedCount":null,"jensenScore":42.52928,"patentCount":3177,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":34.53953985878102,"pubTatorScore":1.5193435049676647,"self":"https://pharos.nih.gov/idg/api/v1/targets(10175)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/publications"},"_namespace":null},{"id":10176,"version":2,"created":1554928570000,"modified":1554928572000,"deprecated":false,"name":"Kelch domain-containing protein 8B","accession":"Q8IXV7","gene":"KLHDC8B","description":"Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5740312622990379,"antibodyCount":113,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.630953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.326397494456742,"pubTatorScore":0.876987165211168,"self":"https://pharos.nih.gov/idg/api/v1/targets(10176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/publications"},"_namespace":null},{"id":10177,"version":2,"created":1554928573000,"modified":1554928576000,"deprecated":false,"name":"Neuron-specific calcium-binding protein hippocalcin","accession":"P84074","gene":"HPCA","description":"Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). 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Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.48379100500581657,"antibodyCount":107,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.500484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.692476528637034,"pubTatorScore":0.5976428700301942,"self":"https://pharos.nih.gov/idg/api/v1/targets(10181)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/publications"},"_namespace":null},{"id":10182,"version":3,"created":1554928593000,"modified":1555039209000,"deprecated":false,"name":"High mobility group protein B3","accession":"O15347","gene":"HMGB3","description":"Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.487990778675097,"antibodyCount":199,"monoclonalCount":20,"pubmedCount":null,"jensenScore":33.115366,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.55945410494074,"pubTatorScore":1.2963920911086544,"self":"https://pharos.nih.gov/idg/api/v1/targets(10182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/publications"},"_namespace":null},{"id":10183,"version":3,"created":1554928597000,"modified":1555039210000,"deprecated":false,"name":"Uncharacterized protein C9orf139","accession":"Q6ZV77","gene":"C9orf139","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/properties"},"_links":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/publications"},"_namespace":null},{"id":10184,"version":2,"created":1554928598000,"modified":1554928602000,"deprecated":false,"name":"E3 ubiquitin-protein ligase Midline-1","accession":"O15344","gene":"MID1","description":"Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.640985331851828,"antibodyCount":171,"monoclonalCount":9,"pubmedCount":null,"jensenScore":44.833377,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.0803356727565,"pubTatorScore":1.9834206002126769,"self":"https://pharos.nih.gov/idg/api/v1/targets(10184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/publications"},"_namespace":null},{"id":10185,"version":2,"created":1554928603000,"modified":1554928604000,"deprecated":false,"name":"Immunoglobulin lambda variable 6-57","accession":"P01721","gene":"IGLV6-57","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 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May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.748925998819267,"antibodyCount":92,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.970481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":36.178856858061025,"pubTatorScore":0.7789546753909928,"self":"https://pharos.nih.gov/idg/api/v1/targets(10229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/publications"},"_namespace":null},{"id":10230,"version":2,"created":1554928749000,"modified":1554928751000,"deprecated":false,"name":"Collagen alpha-1(XXVI) chain","accession":"Q96A83","gene":"COL26A1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":119,"monoclonalCount":14,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.399380213072398,"pubTatorScore":0.8864907251724818,"self":"https://pharos.nih.gov/idg/api/v1/targets(10230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/properties"},"_links":{"count":674,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/publications"},"_namespace":null},{"id":10231,"version":3,"created":1554928752000,"modified":1555039233000,"deprecated":false,"name":"Coatomer subunit epsilon","accession":"O14579","gene":"COPE","description":"The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6309404424872787,"antibodyCount":112,"monoclonalCount":3,"pubmedCount":null,"jensenScore":43.012223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.95822693804714,"pubTatorScore":3.112486381054891,"self":"https://pharos.nih.gov/idg/api/v1/targets(10231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/properties"},"_links":{"count":1221,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/publications"},"_namespace":null},{"id":10232,"version":2,"created":1554928757000,"modified":1554928761000,"deprecated":false,"name":"Citron Rho-interacting kinase","accession":"O14578","gene":"CIT","description":"Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.6961028746748188,"antibodyCount":117,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.693085,"patentCount":163984,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.6360677860659,"pubTatorScore":1.3603665518863925,"self":"https://pharos.nih.gov/idg/api/v1/targets(10232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/publications"},"_namespace":null},{"id":10233,"version":3,"created":1554928762000,"modified":1555039235000,"deprecated":false,"name":"Serine hydrolase-like protein 2","accession":"Q9H4I8","gene":"SERHL2","description":"Probable serine hydrolase. May be related to cell muscle hypertrophy.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.28969258586728874,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.96908,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":23.922883981999068,"pubTatorScore":-1.1760890875887005,"self":"https://pharos.nih.gov/idg/api/v1/targets(10233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/publications"},"_namespace":null},{"id":10234,"version":2,"created":1554928765000,"modified":1554928768000,"deprecated":false,"name":"Phosphatidate phosphatase LPIN2","accession":"Q92539","gene":"LPIN2","description":"Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.506390843603847,"antibodyCount":152,"monoclonalCount":10,"pubmedCount":null,"jensenScore":30.922481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.53282603741445,"pubTatorScore":1.3106687830381085,"self":"https://pharos.nih.gov/idg/api/v1/targets(10234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/publications"},"_namespace":null},{"id":10235,"version":2,"created":1554928769000,"modified":1554928773000,"deprecated":false,"name":"Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1","accession":"Q92538","gene":"GBF1","description":"Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. 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Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.607582667656062,"antibodyCount":61,"monoclonalCount":5,"pubmedCount":null,"jensenScore":4.310628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.06302813767754,"pubTatorScore":1.7940618176885683,"self":"https://pharos.nih.gov/idg/api/v1/targets(10235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/properties"},"_links":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/publications"},"_namespace":null},{"id":10236,"version":2,"created":1554928774000,"modified":1554928774000,"deprecated":false,"name":"Putative uncharacterized protein LOC645739","accession":"Q9H521","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/publications"},"_namespace":null},{"id":10237,"version":2,"created":1554928774000,"modified":1554928777000,"deprecated":false,"name":"PR domain zinc finger protein 12","accession":"Q9H4Q4","gene":"PRDM12","description":"Involved in the positive regulation of histone H3-K9 dimethylation.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-0.9602895115363744,"antibodyCount":105,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.485485,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.77109184204066,"pubTatorScore":0.8702087801161407,"self":"https://pharos.nih.gov/idg/api/v1/targets(10237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/properties"},"_links":{"count":621,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/publications"},"_namespace":null},{"id":10238,"version":2,"created":1554928777000,"modified":1554928782000,"deprecated":false,"name":"Kinesin-like protein KIF21A","accession":"Q7Z4S6","gene":"KIF21A","description":"Microtubule-binding motor protein probably involved in neuronal axonal transport. 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Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.283679403226036,"antibodyCount":475,"monoclonalCount":250,"pubmedCount":null,"jensenScore":171.773673,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":42.869143888653724,"pubTatorScore":1.8312155246183135,"self":"https://pharos.nih.gov/idg/api/v1/targets(10240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/publications"},"_namespace":null},{"id":10241,"version":2,"created":1554928789000,"modified":1554928790000,"deprecated":false,"name":"HERV-H LTR-associating protein 1","accession":"C9JL84","gene":"HHLA1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.23408320494763177,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.777778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.721000441952036,"pubTatorScore":0.31875869313729016,"self":"https://pharos.nih.gov/idg/api/v1/targets(10241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/properties"},"_links":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/links"},"_synonyms":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/publications"},"_namespace":null},{"id":10242,"version":2,"created":1554928790000,"modified":1554928792000,"deprecated":false,"name":"Krueppel-like factor 17","accession":"Q5JT82","gene":"KLF17","description":"Transcription repressor that binds to the promoter of target genes and prevents their expression. 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Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6395675361808215,"antibodyCount":146,"monoclonalCount":5,"pubmedCount":null,"jensenScore":506.827932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.323927173367984,"pubTatorScore":2.59480235306097,"self":"https://pharos.nih.gov/idg/api/v1/targets(10329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/properties"},"_links":{"count":1154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/synonyms"},"_publications":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/publications"},"_namespace":null},{"id":10330,"version":3,"created":1554929166000,"modified":1555039287000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 12","accession":"P58397","gene":"ADAMTS12","description":"Metalloprotease that may play a role in the degradation of COMP. 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May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3591579601541404,"antibodyCount":217,"monoclonalCount":27,"pubmedCount":null,"jensenScore":222.442891,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.49869351417961,"pubTatorScore":1.795427566533399,"self":"https://pharos.nih.gov/idg/api/v1/targets(10338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/publications"},"_namespace":null},{"id":10339,"version":3,"created":1554929216000,"modified":1555039290000,"deprecated":false,"name":"UPF0769 protein C21orf59","accession":"P57076","gene":"C21orf59","description":"Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). 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May suppress canonical Wnt signaling activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.580639957066135,"antibodyCount":106,"monoclonalCount":44,"pubmedCount":null,"jensenScore":36.517155,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":0.0,"pubTatorScore":0.13830269816628146,"self":"https://pharos.nih.gov/idg/api/v1/targets(10339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/publications"},"_namespace":null},{"id":10340,"version":3,"created":1554929220000,"modified":1555039291000,"deprecated":false,"name":"Protein salvador homolog 1","accession":"Q9H4B6","gene":"SAV1","description":"Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. 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Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.624363816030507,"antibodyCount":119,"monoclonalCount":17,"pubmedCount":null,"jensenScore":45.489695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":69,"knowledgeAvailability":19.667962967913528,"pubTatorScore":0.9777236052888477,"self":"https://pharos.nih.gov/idg/api/v1/targets(10351)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/properties"},"_links":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/publications"},"_namespace":null},{"id":10352,"version":2,"created":1554929276000,"modified":1554929279000,"deprecated":false,"name":"T-box transcription factor TBX4","accession":"P57082","gene":"TBX4","description":"Involved in the transcriptional regulation of genes required for mesoderm differentiation. 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Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-2.944338857632132,"antibodyCount":704,"monoclonalCount":153,"pubmedCount":null,"jensenScore":736.044032,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.069474332348584,"pubTatorScore":3.502858418427503,"self":"https://pharos.nih.gov/idg/api/v1/targets(10445)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":653,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/properties"},"_links":{"count":1262,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/publications"},"_namespace":null},{"id":10446,"version":2,"created":1554929709000,"modified":1554929714000,"deprecated":false,"name":"LIM domain transcription factor LMO4","accession":"P61968","gene":"LMO4","description":"Probable transcriptional factor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0835324700895483,"antibodyCount":216,"monoclonalCount":40,"pubmedCount":null,"jensenScore":14.532656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.04977429300067,"pubTatorScore":1.6982493290938172,"self":"https://pharos.nih.gov/idg/api/v1/targets(10446)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/properties"},"_links":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/publications"},"_namespace":null},{"id":10447,"version":3,"created":1554929715000,"modified":1555039377000,"deprecated":false,"name":"RNA-binding protein FUS","accession":"P35637","gene":"FUS","description":"Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. 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IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.107232762020356,"antibodyCount":383,"monoclonalCount":170,"pubmedCount":null,"jensenScore":113.898438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.18596255515151,"pubTatorScore":2.5540013957904057,"self":"https://pharos.nih.gov/idg/api/v1/targets(10483)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":582,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/properties"},"_links":{"count":710,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/synonyms"},"_publications":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/publications"},"_namespace":null},{"id":10484,"version":3,"created":1554929923000,"modified":1555039408000,"deprecated":false,"name":"Adrenocortical dysplasia protein homolog","accession":"Q96AP0","gene":"ACD","description":"Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. 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Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. 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Not required for the production of VSV virus particles.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9697707803451858,"antibodyCount":67,"monoclonalCount":9,"pubmedCount":null,"jensenScore":90.624848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.96121885504348,"pubTatorScore":1.3560258380612067,"self":"https://pharos.nih.gov/idg/api/v1/targets(10486)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/publications"},"_namespace":null},{"id":10487,"version":3,"created":1554929936000,"modified":1555039410000,"deprecated":false,"name":"Ribosomal protein S6 kinase alpha-5","accession":"O75582","gene":"RPS6KA5","description":"Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.9700366029047989,"antibodyCount":671,"monoclonalCount":45,"pubmedCount":null,"jensenScore":92.612963,"patentCount":10862,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":54.3640914549702,"pubTatorScore":1.8829806149653723,"self":"https://pharos.nih.gov/idg/api/v1/targets(10487)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/publications"},"_namespace":null},{"id":10488,"version":3,"created":1554929954000,"modified":1555039412000,"deprecated":false,"name":"Dapper homolog 3","accession":"Q96B18","gene":"DACT3","description":"May be involved in regulation of intracellular signaling pathways during development. 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Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. 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Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-4.002919564528269,"antibodyCount":1455,"monoclonalCount":287,"pubmedCount":null,"jensenScore":9201.686477,"patentCount":365075,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":64.84868539215226,"pubTatorScore":3.5182258301033285,"self":"https://pharos.nih.gov/idg/api/v1/targets(10540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1894,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/properties"},"_links":{"count":2603,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/links"},"_synonyms":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/synonyms"},"_publications":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/publications"},"_namespace":null},{"id":10541,"version":2,"created":1554930738000,"modified":1554930744000,"deprecated":false,"name":"AT-hook-containing transcription factor","accession":"Q7Z591","gene":"AKNA","description":"Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.119600785133339,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.866161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.868174184958292,"pubTatorScore":0.9607544271171863,"self":"https://pharos.nih.gov/idg/api/v1/targets(10541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/publications"},"_namespace":null},{"id":10542,"version":3,"created":1554930746000,"modified":1555039451000,"deprecated":false,"name":"Glutamate decarboxylase 2","accession":"Q05329","gene":"GAD2","description":"Catalyzes the production of GABA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.030467607966655,"antibodyCount":459,"monoclonalCount":94,"pubmedCount":null,"jensenScore":1065.419617,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.91403402548996,"pubTatorScore":2.8304306972549114,"self":"https://pharos.nih.gov/idg/api/v1/targets(10542)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/publications"},"_namespace":null},{"id":10543,"version":2,"created":1554930751000,"modified":1554930752000,"deprecated":false,"name":"Putative ankyrin repeat domain-containing protein 19","accession":"Q9H560","gene":"ANKRD19P","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.541598755655972,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/publications"},"_namespace":null},{"id":10544,"version":2,"created":1554930752000,"modified":1554930755000,"deprecated":false,"name":"Kinesin-like protein KIFC2","accession":"Q96AC6","gene":"KIFC2","description":"May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6859548818274589,"antibodyCount":58,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.335713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.758096870567474,"pubTatorScore":-0.062148240821651324,"self":"https://pharos.nih.gov/idg/api/v1/targets(10544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/publications"},"_namespace":null},{"id":10545,"version":2,"created":1554930756000,"modified":1554930760000,"deprecated":false,"name":"Zinc finger SWIM domain-containing protein 8","accession":"A7E2V4","gene":"ZSWIM8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.35627651704726,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10545)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/publications"},"_namespace":null},{"id":10546,"version":3,"created":1554930761000,"modified":1555039452000,"deprecated":false,"name":"Fermitin family homolog 2","accession":"Q96AC1","gene":"FERMT2","description":"Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8894318366281535,"antibodyCount":180,"monoclonalCount":75,"pubmedCount":null,"jensenScore":85.695755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.23071466957254,"pubTatorScore":1.8038958250426835,"self":"https://pharos.nih.gov/idg/api/v1/targets(10546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/properties"},"_links":{"count":1178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/publications"},"_namespace":null},{"id":10547,"version":3,"created":1554930769000,"modified":1555039454000,"deprecated":false,"name":"AP-3 complex subunit sigma-1","accession":"Q92572","gene":"AP3S1","description":"Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.635148516810052,"antibodyCount":117,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.428953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":39.07409712281573,"pubTatorScore":0.729704648286999,"self":"https://pharos.nih.gov/idg/api/v1/targets(10547)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/publications"},"_namespace":null},{"id":10548,"version":2,"created":1554930775000,"modified":1554930781000,"deprecated":false,"name":"Nuclear receptor subfamily 4 group A member 3","accession":"Q92570","gene":"NR4A3","description":"Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity).","idgFamily":"Nuclear Receptor","idgTDL":"Tbio","novelty":-2.0275199128283115,"antibodyCount":289,"monoclonalCount":88,"pubmedCount":null,"jensenScore":112.675982,"patentCount":152037,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.7545292369438,"pubTatorScore":2.313174867192345,"self":"https://pharos.nih.gov/idg/api/v1/targets(10548)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/publications"},"_namespace":null},{"id":10549,"version":2,"created":1554930782000,"modified":1554930787000,"deprecated":false,"name":"PHD finger protein 3","accession":"Q92576","gene":"PHF3","description":null,"idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.0238075328990646,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.248085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.717555937214485,"pubTatorScore":0.9704243820440289,"self":"https://pharos.nih.gov/idg/api/v1/targets(10549)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/publications"},"_namespace":null},{"id":10550,"version":3,"created":1554930788000,"modified":1555039455000,"deprecated":false,"name":"UBX domain-containing protein 4","accession":"Q92575","gene":"UBXN4","description":"Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.402261386797625,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.404196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.60395057822903,"pubTatorScore":0.4191291422964272,"self":"https://pharos.nih.gov/idg/api/v1/targets(10550)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/publications"},"_namespace":null},{"id":10551,"version":2,"created":1554930796000,"modified":1554930799000,"deprecated":false,"name":"Tumor suppressor candidate gene 1 protein","accession":"Q2TAM9","gene":"TUSC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7359535691415405,"antibodyCount":92,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.2939,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.556242369825544,"pubTatorScore":0.8672710386167818,"self":"https://pharos.nih.gov/idg/api/v1/targets(10551)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/publications"},"_namespace":null},{"id":10552,"version":3,"created":1554930800000,"modified":1555039456000,"deprecated":false,"name":"Hamartin","accession":"Q92574","gene":"TSC1","description":"In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2545051770132143,"antibodyCount":1622,"monoclonalCount":171,"pubmedCount":null,"jensenScore":173.923533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":54.80535582373198,"pubTatorScore":2.842958924246618,"self":"https://pharos.nih.gov/idg/api/v1/targets(10552)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":708,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/properties"},"_links":{"count":1413,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/synonyms"},"_publications":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/publications"},"_namespace":null},{"id":10553,"version":2,"created":1554930812000,"modified":1554930819000,"deprecated":false,"name":"Splicing factor 3B subunit 1","accession":"O75533","gene":"SF3B1","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). 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Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.831443151241423,"antibodyCount":76,"monoclonalCount":1,"pubmedCount":null,"jensenScore":8.577451,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.42359614033769,"pubTatorScore":0.7596678446896304,"self":"https://pharos.nih.gov/idg/api/v1/targets(10612)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/properties"},"_links":{"count":1063,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/publications"},"_namespace":null},{"id":10613,"version":2,"created":1554931135000,"modified":1554931140000,"deprecated":false,"name":"Sorting nexin-19","accession":"Q92543","gene":"SNX19","description":"Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). 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PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. 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Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4468221215839163,"antibodyCount":157,"monoclonalCount":5,"pubmedCount":null,"jensenScore":29.055308,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.47697646302069,"pubTatorScore":0.7639694756656794,"self":"https://pharos.nih.gov/idg/api/v1/targets(10615)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/publications"},"_namespace":null},{"id":10616,"version":2,"created":1554931155000,"modified":1554931160000,"deprecated":false,"name":"DNA topoisomerase 2-binding protein 1","accession":"Q92547","gene":"TOPBP1","description":"Required for DNA replication. 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Minor subunit located with subunit a in the membrane (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10684)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/properties"},"_links":{"count":565,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/publications"},"_namespace":null},{"id":10685,"version":3,"created":1554932410000,"modified":1555039574000,"deprecated":false,"name":"Sodium/hydrogen exchanger 6","accession":"Q92581","gene":"SLC9A6","description":"Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. 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Possible housekeeping role.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4762068555415746,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":17.163212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.413526806110518,"pubTatorScore":1.3690947763063042,"self":"https://pharos.nih.gov/idg/api/v1/targets(10686)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/properties"},"_links":{"count":535,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/publications"},"_namespace":null},{"id":10687,"version":4,"created":1554932419000,"modified":1555039578000,"deprecated":false,"name":"Cyclin-dependent kinase 2","accession":"P24941","gene":"CDK2","description":"Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.4426612552140847,"antibodyCount":1114,"monoclonalCount":310,"pubmedCount":null,"jensenScore":2522.81647,"patentCount":142021,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":66.10358282077244,"pubTatorScore":3.1994737051848943,"self":"https://pharos.nih.gov/idg/api/v1/targets(10687)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/properties"},"_links":{"count":1880,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/links"},"_synonyms":{"count":1404,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/synonyms"},"_publications":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/publications"},"_namespace":null},{"id":10688,"version":3,"created":1554932550000,"modified":1555039583000,"deprecated":false,"name":"Mastermind-like protein 1","accession":"Q92585","gene":"MAML1","description":"Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6596239101251231,"antibodyCount":189,"monoclonalCount":16,"pubmedCount":null,"jensenScore":41.274076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.190771922888864,"pubTatorScore":1.5454175814880102,"self":"https://pharos.nih.gov/idg/api/v1/targets(10688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/publications"},"_namespace":null},{"id":10689,"version":3,"created":1554932554000,"modified":1555039584000,"deprecated":false,"name":"Serine protease inhibitor Kazal-type 1","accession":"P00995","gene":"SPINK1","description":"In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.8540674408241307,"antibodyCount":190,"monoclonalCount":46,"pubmedCount":null,"jensenScore":743.990046,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.837224221663654,"pubTatorScore":3.0974491598603118,"self":"https://pharos.nih.gov/idg/api/v1/targets(10689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/synonyms"},"_publications":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/publications"},"_namespace":null},{"id":10690,"version":3,"created":1554932559000,"modified":1555039586000,"deprecated":false,"name":"CD48 antigen","accession":"P09326","gene":"CD48","description":"Ligand for CD2. 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Probably involved in regulating T-cell activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5770688987513197,"antibodyCount":679,"monoclonalCount":455,"pubmedCount":null,"jensenScore":369.226204,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.44564341186365,"pubTatorScore":2.18179230102412,"self":"https://pharos.nih.gov/idg/api/v1/targets(10690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/publications"},"_namespace":null},{"id":10691,"version":2,"created":1554932564000,"modified":1554932568000,"deprecated":false,"name":"Villin-1","accession":"P09327","gene":"VIL1","description":"Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2013728305666236,"antibodyCount":349,"monoclonalCount":188,"pubmedCount":null,"jensenScore":162.538054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.510772497548277,"pubTatorScore":1.9239589740213998,"self":"https://pharos.nih.gov/idg/api/v1/targets(10691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/publications"},"_namespace":null},{"id":10692,"version":2,"created":1554932569000,"modified":1554932573000,"deprecated":false,"name":"BolA-like protein 2","accession":"Q9H3K6","gene":"BOLA2B","description":"Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3969738343799864,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.487281,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.62404083932053,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/properties"},"_links":{"count":1751,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/publications"},"_namespace":null},{"id":10693,"version":3,"created":1554932574000,"modified":1554932606000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 10","accession":"O14672","gene":"ADAM10","description":"Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.6465184732969074,"antibodyCount":384,"monoclonalCount":123,"pubmedCount":null,"jensenScore":422.39721,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.28484256263841,"pubTatorScore":2.5218180030042308,"self":"https://pharos.nih.gov/idg/api/v1/targets(10693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":737,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/properties"},"_links":{"count":1552,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/synonyms"},"_publications":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/publications"},"_namespace":null},{"id":10694,"version":3,"created":1554932608000,"modified":1555039588000,"deprecated":false,"name":"Growth hormone-inducible transmembrane protein","accession":"Q9H3K2","gene":"GHITM","description":"Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8220723783580162,"antibodyCount":166,"monoclonalCount":2,"pubmedCount":null,"jensenScore":66.536151,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":33.586785827158195,"pubTatorScore":1.3561017659995327,"self":"https://pharos.nih.gov/idg/api/v1/targets(10694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/publications"},"_namespace":null},{"id":10695,"version":3,"created":1554932613000,"modified":1555039589000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 13B","accession":"Q3SXY8","gene":"ARL13B","description":"Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5120468493328956,"antibodyCount":74,"monoclonalCount":8,"pubmedCount":null,"jensenScore":32.927493,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":32.04389531379206,"pubTatorScore":1.2550251522241294,"self":"https://pharos.nih.gov/idg/api/v1/targets(10695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/publications"},"_namespace":null},{"id":10696,"version":2,"created":1554932617000,"modified":1554932622000,"deprecated":false,"name":"Dyslexia-associated protein KIAA0319","accession":"Q5VV43","gene":"KIAA0319","description":"Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6533214267722187,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.226046,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.61977136193259,"pubTatorScore":1.7868387831894277,"self":"https://pharos.nih.gov/idg/api/v1/targets(10696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/publications"},"_namespace":null},{"id":10697,"version":3,"created":1554932623000,"modified":1555039590000,"deprecated":false,"name":"Threonylcarbamoyladenosine tRNA methylthiotransferase","accession":"Q5VV42","gene":"CDKAL1","description":"Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8202704487347459,"antibodyCount":160,"monoclonalCount":6,"pubmedCount":null,"jensenScore":71.26196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":40.73915089840046,"pubTatorScore":1.9387441643972352,"self":"https://pharos.nih.gov/idg/api/v1/targets(10697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":473,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/synonyms"},"_publications":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/publications"},"_namespace":null},{"id":10698,"version":3,"created":1554932628000,"modified":1555039592000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 16","accession":"Q5VV41","gene":"ARHGEF16","description":"Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. 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Required for maintaining open chromatin and pluripotency in embryonic stem cells.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.1447165296856276,"antibodyCount":122,"monoclonalCount":28,"pubmedCount":null,"jensenScore":148.26088,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.996514963961395,"pubTatorScore":1.7867917486317495,"self":"https://pharos.nih.gov/idg/api/v1/targets(10784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/publications"},"_namespace":null},{"id":10785,"version":2,"created":1554933521000,"modified":1554933521000,"deprecated":false,"name":"Transcription factor SPT20 homolog-like 1","accession":"Q3ZLR7","gene":"SUPT20HL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.052404884202492,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/properties"},"_links":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/publications"},"_namespace":null},{"id":10786,"version":3,"created":1554933521000,"modified":1555039629000,"deprecated":false,"name":"Voltage-dependent calcium channel gamma-1 subunit","accession":"Q06432","gene":"CACNG1","description":"This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. 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Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4837510772787903,"antibodyCount":132,"monoclonalCount":18,"pubmedCount":null,"jensenScore":32.405861,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.9175332289961,"pubTatorScore":1.2588766533002014,"self":"https://pharos.nih.gov/idg/api/v1/targets(10788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/publications"},"_namespace":null},{"id":10789,"version":2,"created":1554933531000,"modified":1554933533000,"deprecated":false,"name":"Insulin receptor substrate 4","accession":"O14654","gene":"IRS4","description":"Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6042933070549534,"antibodyCount":121,"monoclonalCount":66,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.170970092576674,"pubTatorScore":1.633807608107414,"self":"https://pharos.nih.gov/idg/api/v1/targets(10789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/properties"},"_links":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/publications"},"_namespace":null},{"id":10790,"version":3,"created":1554933534000,"modified":1555039631000,"deprecated":false,"name":"Golgi SNAP receptor complex member 2","accession":"O14653","gene":"GOSR2","description":"Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3504598250157989,"antibodyCount":88,"monoclonalCount":17,"pubmedCount":null,"jensenScore":17.942571,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":42.860091008745336,"pubTatorScore":1.3301736273531446,"self":"https://pharos.nih.gov/idg/api/v1/targets(10790)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/properties"},"_links":{"count":1096,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/publications"},"_namespace":null},{"id":10791,"version":3,"created":1554933538000,"modified":1555039633000,"deprecated":false,"name":"Torsin-1A","accession":"O14656","gene":"TOR1A","description":"Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. 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Probably required to interact with the RNA polymerase II complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7981763840056446,"antibodyCount":160,"monoclonalCount":36,"pubmedCount":null,"jensenScore":5.600534,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":37.86085046886719,"pubTatorScore":1.0777943946746038,"self":"https://pharos.nih.gov/idg/api/v1/targets(11022)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(11022)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(11022)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(11022)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(11022)/publications"},"_namespace":null},{"id":11023,"version":3,"created":1554935258000,"modified":1555039787000,"deprecated":false,"name":"Mitochondrial antiviral-signaling protein","accession":"Q7Z434","gene":"MAVS","description":"Required for innate immune defense against viruses. 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Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5309919812016888,"antibodyCount":157,"monoclonalCount":7,"pubmedCount":null,"jensenScore":37.539966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.3236943896327,"pubTatorScore":1.2760746729984282,"self":"https://pharos.nih.gov/idg/api/v1/targets(11037)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/publications"},"_namespace":null},{"id":11038,"version":2,"created":1554935307000,"modified":1554935321000,"deprecated":false,"name":"Alcohol dehydrogenase class-3","accession":"P11766","gene":"ADH5","description":"Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.37411469945803,"antibodyCount":283,"monoclonalCount":27,"pubmedCount":null,"jensenScore":239.487009,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.84870111136859,"pubTatorScore":2.3292314364027606,"self":"https://pharos.nih.gov/idg/api/v1/targets(11038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/properties"},"_links":{"count":1098,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/publications"},"_namespace":null},{"id":11039,"version":3,"created":1554935323000,"modified":1555039798000,"deprecated":false,"name":"Leucine-rich repeat neuronal protein 3","accession":"Q9H3W5","gene":"LRRN3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.944913309634738,"antibodyCount":146,"monoclonalCount":1,"pubmedCount":null,"jensenScore":9.903764,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":28.824031709663224,"pubTatorScore":0.7063518481650557,"self":"https://pharos.nih.gov/idg/api/v1/targets(11039)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/publications"},"_namespace":null},{"id":11040,"version":3,"created":1554935326000,"modified":1555039799000,"deprecated":false,"name":"Piwi-like protein 4","accession":"Q7Z3Z4","gene":"PIWIL4","description":"Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7580104861779606,"antibodyCount":177,"monoclonalCount":39,"pubmedCount":null,"jensenScore":535.105379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.589640396121805,"pubTatorScore":1.1549501943951999,"self":"https://pharos.nih.gov/idg/api/v1/targets(11040)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/publications"},"_namespace":null},{"id":11041,"version":2,"created":1554935331000,"modified":1554935333000,"deprecated":false,"name":"Piwi-like protein 3","accession":"Q7Z3Z3","gene":"PIWIL3","description":"May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7842973897796739,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.457948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.763982616546821,"pubTatorScore":0.6565506678973989,"self":"https://pharos.nih.gov/idg/api/v1/targets(11041)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/properties"},"_links":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/publications"},"_namespace":null},{"id":11042,"version":3,"created":1554935333000,"modified":1555039801000,"deprecated":false,"name":"Upstream stimulatory factor 1","accession":"P22415","gene":"USF1","description":"Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.763215935918238,"antibodyCount":246,"monoclonalCount":53,"pubmedCount":null,"jensenScore":593.805053,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.670058599636974,"pubTatorScore":2.4983587895086887,"self":"https://pharos.nih.gov/idg/api/v1/targets(11042)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":525,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/publications"},"_namespace":null},{"id":11043,"version":2,"created":1554935339000,"modified":1554935340000,"deprecated":false,"name":"Complement factor H-related protein 4","accession":"Q92496","gene":"CFHR4","description":"Involved in complement regulation. 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The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8693867644758289,"antibodyCount":115,"monoclonalCount":2,"pubmedCount":null,"jensenScore":69.536161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.85430320106696,"pubTatorScore":3.6929804939707123,"self":"https://pharos.nih.gov/idg/api/v1/targets(11050)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(11050)/properties"},"_links":{"count":1107,"href":"https://pharos.nih.gov/idg/api/v1/targets(11050)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(11050)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(11050)/publications"},"_namespace":null},{"id":11051,"version":2,"created":1554935376000,"modified":1554935378000,"deprecated":false,"name":"Keratin, type I cytoskeletal 25","accession":"Q7Z3Z0","gene":"KRT25","description":"Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). 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Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.535715963905387,"antibodyCount":95,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.980254,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.55728784794782,"pubTatorScore":0.6197886888012714,"self":"https://pharos.nih.gov/idg/api/v1/targets(11070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/publications"},"_namespace":null},{"id":11071,"version":2,"created":1554935765000,"modified":1554935766000,"deprecated":false,"name":"Keratin-associated protein 19-7","accession":"Q3SYF9","gene":"KRTAP19-7","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.888999586223538,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/properties"},"_links":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/publications"},"_namespace":null},{"id":11072,"version":2,"created":1554935766000,"modified":1554935768000,"deprecated":false,"name":"Keratin, type I cytoskeletal 26","accession":"Q7Z3Y9","gene":"KRT26","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5335723812091486,"antibodyCount":82,"monoclonalCount":7,"pubmedCount":null,"jensenScore":34.996427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.480671460628079,"pubTatorScore":0.9785391755018805,"self":"https://pharos.nih.gov/idg/api/v1/targets(11072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/properties"},"_links":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/publications"},"_namespace":null},{"id":11073,"version":2,"created":1554935769000,"modified":1554935771000,"deprecated":false,"name":"Paired box protein Pax-7","accession":"P23759","gene":"PAX7","description":"Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.7070288181384083,"antibodyCount":418,"monoclonalCount":166,"pubmedCount":null,"jensenScore":468.710886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.93636235544281,"pubTatorScore":2.3193383894862,"self":"https://pharos.nih.gov/idg/api/v1/targets(11073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/properties"},"_links":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/publications"},"_namespace":null},{"id":11074,"version":2,"created":1554935772000,"modified":1554935774000,"deprecated":false,"name":"Keratin, type I cytoskeletal 27","accession":"Q7Z3Y8","gene":"KRT27","description":"Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.040617852614420934,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.920119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.396278965668543,"pubTatorScore":1.6123464714821578,"self":"https://pharos.nih.gov/idg/api/v1/targets(11074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/publications"},"_namespace":null},{"id":11075,"version":3,"created":1554935774000,"modified":1555039830000,"deprecated":false,"name":"Apoptosis regulator BAX","accession":"Q07812","gene":"BAX","description":"Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.578336855192859,"antibodyCount":1395,"monoclonalCount":500,"pubmedCount":null,"jensenScore":248.409133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":59.788090856424276,"pubTatorScore":3.6575194966446265,"self":"https://pharos.nih.gov/idg/api/v1/targets(11075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1464,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/properties"},"_links":{"count":1989,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/links"},"_synonyms":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/synonyms"},"_publications":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/publications"},"_namespace":null},{"id":11076,"version":2,"created":1554935789000,"modified":1554935793000,"deprecated":false,"name":"Aquaporin-3","accession":"Q92482","gene":"AQP3","description":"Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6171709915741235,"antibodyCount":260,"monoclonalCount":0,"pubmedCount":null,"jensenScore":402.996969,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.96645543095002,"pubTatorScore":2.3056353223894535,"self":"https://pharos.nih.gov/idg/api/v1/targets(11076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/synonyms"},"_publications":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/publications"},"_namespace":null},{"id":11077,"version":3,"created":1554935794000,"modified":1555039835000,"deprecated":false,"name":"Rho-related GTP-binding protein RhoC","accession":"P08134","gene":"RHOC","description":"Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.3409523064232283,"antibodyCount":224,"monoclonalCount":73,"pubmedCount":null,"jensenScore":216.36824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":37.999616788164275,"pubTatorScore":2.3685847682518717,"self":"https://pharos.nih.gov/idg/api/v1/targets(11077)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/properties"},"_links":{"count":1168,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/synonyms"},"_publications":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/publications"},"_namespace":null},{"id":11078,"version":2,"created":1554935799000,"modified":1554935802000,"deprecated":false,"name":"Glycodelin","accession":"P09466","gene":"PAEP","description":"Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.851656518651632,"antibodyCount":237,"monoclonalCount":67,"pubmedCount":null,"jensenScore":716.873215,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.297641968052936,"pubTatorScore":2.947489278126487,"self":"https://pharos.nih.gov/idg/api/v1/targets(11078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/properties"},"_links":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/publications"},"_namespace":null},{"id":11079,"version":2,"created":1554935803000,"modified":1554935808000,"deprecated":false,"name":"Annexin A6","accession":"P08133","gene":"ANXA6","description":"May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.448933228551649,"antibodyCount":381,"monoclonalCount":39,"pubmedCount":null,"jensenScore":298.751732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.176387378208396,"pubTatorScore":2.3216207286467716,"self":"https://pharos.nih.gov/idg/api/v1/targets(11079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/properties"},"_links":{"count":1182,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/publications"},"_namespace":null},{"id":11080,"version":3,"created":1554935809000,"modified":1555039837000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 16","accession":"P08138","gene":"NGFR","description":"Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.062391848301761,"antibodyCount":881,"monoclonalCount":403,"pubmedCount":null,"jensenScore":1162.143121,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":47.33357900606395,"pubTatorScore":2.8523614760696523,"self":"https://pharos.nih.gov/idg/api/v1/targets(11080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/properties"},"_links":{"count":1233,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/synonyms"},"_publications":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/publications"},"_namespace":null},{"id":11081,"version":3,"created":1554935818000,"modified":1554935907000,"deprecated":false,"name":"Fructose-1,6-bisphosphatase 1","accession":"P09467","gene":"FBP1","description":"Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.0682371115188225,"antibodyCount":202,"monoclonalCount":11,"pubmedCount":null,"jensenScore":111.802414,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.892380901919175,"pubTatorScore":2.056337478960672,"self":"https://pharos.nih.gov/idg/api/v1/targets(11081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/properties"},"_links":{"count":1304,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/links"},"_synonyms":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/publications"},"_namespace":null},{"id":11082,"version":2,"created":1554935909000,"modified":1554935914000,"deprecated":false,"name":"Death effector domain-containing protein","accession":"O75618","gene":"DEDD","description":"A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.38138193892328,"antibodyCount":166,"monoclonalCount":22,"pubmedCount":null,"jensenScore":233.441752,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.96125691801591,"pubTatorScore":1.0407341510299568,"self":"https://pharos.nih.gov/idg/api/v1/targets(11082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/publications"},"_namespace":null},{"id":11083,"version":3,"created":1554935915000,"modified":1555039839000,"deprecated":false,"name":"High mobility group protein B1","accession":"P09429","gene":"HMGB1","description":"In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). 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Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.062368784948053,"antibodyCount":58,"monoclonalCount":8,"pubmedCount":null,"jensenScore":118.064993,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.813862408409946,"pubTatorScore":1.7126959313291779,"self":"https://pharos.nih.gov/idg/api/v1/targets(11349)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/links"},"_synonyms":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/publications"},"_namespace":null},{"id":11350,"version":3,"created":1554939194000,"modified":1555040017000,"deprecated":false,"name":"Radial spoke head 10 homolog B2","accession":"B2RC85","gene":"RSPH10B2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":8.404918171859942,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11350)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/publications"},"_namespace":null},{"id":11351,"version":3,"created":1554939196000,"modified":1555040019000,"deprecated":false,"name":"Receptor-type tyrosine-protein phosphatase delta","accession":"P23468","gene":"PTPRD","description":"Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. 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Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). 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Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.551954124167235,"antibodyCount":432,"monoclonalCount":89,"pubmedCount":null,"jensenScore":357.014979,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":51.94818116841506,"pubTatorScore":2.3662490327617243,"self":"https://pharos.nih.gov/idg/api/v1/targets(11354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":662,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/synonyms"},"_publications":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/publications"},"_namespace":null},{"id":11355,"version":2,"created":1554939218000,"modified":1554939221000,"deprecated":false,"name":"Cartilage intermediate layer protein 1","accession":"O75339","gene":"CILP","description":"Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4899650490471519,"antibodyCount":120,"monoclonalCount":27,"pubmedCount":null,"jensenScore":33.654313,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.02423825766472,"pubTatorScore":1.527389451680619,"self":"https://pharos.nih.gov/idg/api/v1/targets(11355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/publications"},"_namespace":null},{"id":11356,"version":3,"created":1554939222000,"modified":1555040024000,"deprecated":false,"name":"Liprin-alpha-4","accession":"O75335","gene":"PPFIA4","description":"May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.126319643027829,"antibodyCount":31,"monoclonalCount":11,"pubmedCount":null,"jensenScore":1.07186,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.48968270508621,"pubTatorScore":-0.24303772296555518,"self":"https://pharos.nih.gov/idg/api/v1/targets(11356)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/publications"},"_namespace":null},{"id":11357,"version":2,"created":1554939226000,"modified":1554939234000,"deprecated":false,"name":"Transcriptional regulator ATRX","accession":"P46100","gene":"ATRX","description":"Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomers. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomers nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8527659229970244,"antibodyCount":248,"monoclonalCount":118,"pubmedCount":null,"jensenScore":705.859796,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.96409288592764,"pubTatorScore":2.4463639164349584,"self":"https://pharos.nih.gov/idg/api/v1/targets(11357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/properties"},"_links":{"count":1547,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/links"},"_synonyms":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/synonyms"},"_publications":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/publications"},"_namespace":null},{"id":11358,"version":2,"created":1554939236000,"modified":1554939237000,"deprecated":false,"name":"T-box transcription factor TBX10","accession":"O75333","gene":"TBX10","description":"Probable transcriptional regulator involved in developmental processes.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.8933191399946753,"antibodyCount":110,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.846197,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.92123634235105,"pubTatorScore":0.6299473426386697,"self":"https://pharos.nih.gov/idg/api/v1/targets(11358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/properties"},"_links":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/publications"},"_namespace":null},{"id":11359,"version":2,"created":1554939238000,"modified":1554939243000,"deprecated":false,"name":"Lon protease homolog, mitochondrial","accession":"P36776","gene":"LONP1","description":"ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2480461079976726,"antibodyCount":174,"monoclonalCount":38,"pubmedCount":null,"jensenScore":169.598442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.482779411272936,"pubTatorScore":2.333431956025404,"self":"https://pharos.nih.gov/idg/api/v1/targets(11359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/properties"},"_links":{"count":1230,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/links"},"_synonyms":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/publications"},"_namespace":null},{"id":11360,"version":3,"created":1554939244000,"modified":1555040025000,"deprecated":false,"name":"Liprin-alpha-2","accession":"O75334","gene":"PPFIA2","description":"Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. 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Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9198842174686137,"antibodyCount":124,"monoclonalCount":7,"pubmedCount":null,"jensenScore":87.237174,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.1020590418601,"pubTatorScore":1.6947218286280274,"self":"https://pharos.nih.gov/idg/api/v1/targets(11361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/properties"},"_links":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/publications"},"_namespace":null},{"id":11362,"version":3,"created":1554939253000,"modified":1555040026000,"deprecated":false,"name":"Thrombospondin-2","accession":"P35442","gene":"THBS2","description":"Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3560777497979464,"antibodyCount":150,"monoclonalCount":32,"pubmedCount":null,"jensenScore":237.670691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":38.81499148879512,"pubTatorScore":2.114368455453351,"self":"https://pharos.nih.gov/idg/api/v1/targets(11362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/publications"},"_namespace":null},{"id":11363,"version":3,"created":1554939258000,"modified":1555040028000,"deprecated":false,"name":"Hyaluronan mediated motility receptor","accession":"O75330","gene":"HMMR","description":"Receptor for hyaluronic acid (HA) (By similarity). 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Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. 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Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.1836128545976496,"antibodyCount":1818,"monoclonalCount":222,"pubmedCount":null,"jensenScore":0.0,"patentCount":50455,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":57.63199334862673,"pubTatorScore":2.9012400109443472,"self":"https://pharos.nih.gov/idg/api/v1/targets(11382)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/properties"},"_links":{"count":1653,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/links"},"_synonyms":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/synonyms"},"_publications":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/publications"},"_namespace":null},{"id":11383,"version":2,"created":1554939415000,"modified":1554939417000,"deprecated":false,"name":"RNA/RNP complex-1-interacting phosphatase","accession":"O75319","gene":"DUSP11","description":"Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. 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Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0669024866150023,"antibodyCount":173,"monoclonalCount":28,"pubmedCount":null,"jensenScore":11.629333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.638165954130336,"pubTatorScore":0.8749233095560187,"self":"https://pharos.nih.gov/idg/api/v1/targets(11384)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/publications"},"_namespace":null},{"id":11385,"version":2,"created":1554939422000,"modified":1554939423000,"deprecated":false,"name":"Protein FAM47A","accession":"Q5JRC9","gene":"FAM47A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.775078723404748,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11385)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/properties"},"_links":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/publications"},"_namespace":null},{"id":11386,"version":2,"created":1554939423000,"modified":1554939425000,"deprecated":false,"name":"Protein FAM98C","accession":"Q17RN3","gene":"FAM98C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.4471549913744,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11386)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/publications"},"_namespace":null},{"id":11387,"version":2,"created":1554939426000,"modified":1554939431000,"deprecated":false,"name":"Mannan-binding lectin serine protease 1","accession":"P48740","gene":"MASP1","description":"Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.490402355367013,"antibodyCount":223,"monoclonalCount":32,"pubmedCount":null,"jensenScore":334.043653,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.81372405607422,"pubTatorScore":2.2180236972826624,"self":"https://pharos.nih.gov/idg/api/v1/targets(11387)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/links"},"_synonyms":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/publications"},"_namespace":null},{"id":11388,"version":3,"created":1554939432000,"modified":1555040042000,"deprecated":false,"name":"Glycine receptor subunit alpha-3","accession":"O75311","gene":"GLRA3","description":"Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.1193711364439842,"antibodyCount":82,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.876657,"patentCount":1064,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.929602600151817,"pubTatorScore":1.3439007122496063,"self":"https://pharos.nih.gov/idg/api/v1/targets(11388)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/properties"},"_links":{"count":640,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/publications"},"_namespace":null},{"id":11389,"version":2,"created":1554939438000,"modified":1554939442000,"deprecated":false,"name":"Zinc finger protein ZPR1","accession":"O75312","gene":"ZPR1","description":"Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4115291797652552,"antibodyCount":201,"monoclonalCount":57,"pubmedCount":null,"jensenScore":28.232085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.776792907751656,"pubTatorScore":1.2862218109929586,"self":"https://pharos.nih.gov/idg/api/v1/targets(11389)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/publications"},"_namespace":null},{"id":11390,"version":2,"created":1554939443000,"modified":1554939446000,"deprecated":false,"name":"C-C motif chemokine 3","accession":"P10147","gene":"CCL3","description":"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1622853317150885,"antibodyCount":677,"monoclonalCount":234,"pubmedCount":null,"jensenScore":1382.613702,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.922620472659503,"pubTatorScore":2.932079474157689,"self":"https://pharos.nih.gov/idg/api/v1/targets(11390)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/properties"},"_links":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/links"},"_synonyms":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/synonyms"},"_publications":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/publications"},"_namespace":null},{"id":11391,"version":2,"created":1554939447000,"modified":1554939449000,"deprecated":false,"name":"UDP-glucuronosyltransferase 2B11","accession":"O75310","gene":"UGT2B11","description":"UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.26857527440133455,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.792879,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.797353300897246,"pubTatorScore":0.7522924297123683,"self":"https://pharos.nih.gov/idg/api/v1/targets(11391)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/properties"},"_links":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/publications"},"_namespace":null},{"id":11392,"version":2,"created":1554939449000,"modified":1554939465000,"deprecated":false,"name":"Steroid hormone receptor ERR1","accession":"P11474","gene":"ESRRA","description":"Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.","idgFamily":"Nuclear Receptor","idgTDL":"Tchem","novelty":-2.134511670087567,"antibodyCount":356,"monoclonalCount":58,"pubmedCount":null,"jensenScore":156.694128,"patentCount":7551,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.59663101235177,"pubTatorScore":2.230409314470212,"self":"https://pharos.nih.gov/idg/api/v1/targets(11392)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/publications"},"_namespace":null},{"id":11393,"version":2,"created":1554939466000,"modified":1554939469000,"deprecated":false,"name":"Transmembrane protein 119","accession":"Q4V9L6","gene":"TMEM119","description":"Plays an important role in bone formation and normal bone mineralization. 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Essential for normal spermatogenesis and late testicular differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9867628604177555,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.843337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.341076392294397,"pubTatorScore":0.2792150792911802,"self":"https://pharos.nih.gov/idg/api/v1/targets(11393)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/publications"},"_namespace":null},{"id":11394,"version":3,"created":1554939470000,"modified":1554939537000,"deprecated":false,"name":"Vitamin D3 receptor","accession":"P11473","gene":"VDR","description":"Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.","idgFamily":"Nuclear Receptor","idgTDL":"Tclin","novelty":-3.6216566164252297,"antibodyCount":575,"monoclonalCount":123,"pubmedCount":null,"jensenScore":3805.660716,"patentCount":27459,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.87295175288682,"pubTatorScore":3.639271891994898,"self":"https://pharos.nih.gov/idg/api/v1/targets(11394)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2029,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/properties"},"_links":{"count":2368,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/links"},"_synonyms":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/synonyms"},"_publications":{"count":1688,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/publications"},"_namespace":null},{"id":11395,"version":2,"created":1554939543000,"modified":1554939553000,"deprecated":false,"name":"Granzyme B","accession":"P10144","gene":"GZMB","description":"This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. 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Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.7568229993106317,"antibodyCount":722,"monoclonalCount":183,"pubmedCount":null,"jensenScore":579.453422,"patentCount":17196,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.16771641844534,"pubTatorScore":2.261484221649041,"self":"https://pharos.nih.gov/idg/api/v1/targets(11401)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/properties"},"_links":{"count":1603,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/links"},"_synonyms":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/synonyms"},"_publications":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/publications"},"_namespace":null},{"id":11402,"version":2,"created":1554940056000,"modified":1554940063000,"deprecated":false,"name":"Isocitrate dehydrogenase [NADP], mitochondrial","accession":"P48735","gene":"IDH2","description":"Plays a role in intermediary metabolism and energy production. 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Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5374191876313887,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":34.314108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.765155366873365,"pubTatorScore":1.3418739585724149,"self":"https://pharos.nih.gov/idg/api/v1/targets(11436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/publications"},"_namespace":null},{"id":11437,"version":3,"created":1554940181000,"modified":1555040069000,"deprecated":false,"name":"Presenilins-associated rhomboid-like protein, mitochondrial","accession":"Q9H300","gene":"PARL","description":"Required for the control of apoptosis during postnatal growth. 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Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. 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Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. 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Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8341784133749252,"antibodyCount":140,"monoclonalCount":4,"pubmedCount":null,"jensenScore":6.758973,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.977890279931795,"pubTatorScore":0.8315193831048101,"self":"https://pharos.nih.gov/idg/api/v1/targets(11533)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/publications"},"_namespace":null},{"id":11534,"version":2,"created":1554943460000,"modified":1554943463000,"deprecated":false,"name":"Kelch-like protein 38","accession":"Q2WGJ6","gene":"KLHL38","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.835988574408448,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11534)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/properties"},"_links":{"count":754,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/publications"},"_namespace":null},{"id":11535,"version":2,"created":1554943463000,"modified":1554943464000,"deprecated":false,"name":"Transmembrane protein 249","accession":"Q2WGJ8","gene":"TMEM249","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.425004290203958,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11535)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/properties"},"_links":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/publications"},"_namespace":null},{"id":11536,"version":2,"created":1554943464000,"modified":1554943471000,"deprecated":false,"name":"Transient receptor potential cation channel subfamily V member 6","accession":"Q9H1D0","gene":"TRPV6","description":"Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.3829891688009153,"antibodyCount":126,"monoclonalCount":0,"pubmedCount":null,"jensenScore":247.09128,"patentCount":25242,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.01981007461905,"pubTatorScore":2.265833975201869,"self":"https://pharos.nih.gov/idg/api/v1/targets(11536)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/properties"},"_links":{"count":962,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/publications"},"_namespace":null},{"id":11537,"version":3,"created":1554943472000,"modified":1555040132000,"deprecated":false,"name":"5-hydroxytryptamine receptor 3D","accession":"Q70Z44","gene":"HTR3D","description":"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. 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Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6519803458833617,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.333664,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.596281786239125,"pubTatorScore":1.4769276175544086,"self":"https://pharos.nih.gov/idg/api/v1/targets(11540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/publications"},"_namespace":null},{"id":11541,"version":2,"created":1554943494000,"modified":1554943497000,"deprecated":false,"name":"Talin rod domain-containing protein 1","accession":"Q9H1K6","gene":"TLNRD1","description":"Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3357921033708414,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.481944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.425968786559088,"self":"https://pharos.nih.gov/idg/api/v1/targets(11541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/publications"},"_namespace":null},{"id":11542,"version":2,"created":1554943497000,"modified":1554943502000,"deprecated":false,"name":"Mitochondrial glutamate carrier 2","accession":"Q9H1K4","gene":"SLC25A18","description":"Involved in the transport of glutamate across the inner mitochondrial membrane. 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First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2583946389688583,"antibodyCount":167,"monoclonalCount":49,"pubmedCount":null,"jensenScore":167.285193,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.40015462524036,"pubTatorScore":1.7933912019647085,"self":"https://pharos.nih.gov/idg/api/v1/targets(11543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/properties"},"_links":{"count":1209,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/publications"},"_namespace":null},{"id":11544,"version":3,"created":1554943507000,"modified":1555040133000,"deprecated":false,"name":"Rabenosyn-5","accession":"Q9H1K0","gene":"RBSN","description":"Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2447404495576526,"antibodyCount":121,"monoclonalCount":5,"pubmedCount":null,"jensenScore":148.413177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":36.88789414900067,"pubTatorScore":1.0958587566115814,"self":"https://pharos.nih.gov/idg/api/v1/targets(11544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/publications"},"_namespace":null},{"id":11545,"version":4,"created":1554943513000,"modified":1555040135000,"deprecated":false,"name":"Tyrosine-protein kinase ITK/TSK","accession":"Q08881","gene":"ITK","description":"Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. 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Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). 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This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.2563491516796805,"antibodyCount":391,"monoclonalCount":146,"pubmedCount":null,"jensenScore":3246.060125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.853565987300172,"self":"https://pharos.nih.gov/idg/api/v1/targets(11626)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":674,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/properties"},"_links":{"count":1169,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/links"},"_synonyms":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/synonyms"},"_publications":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/publications"},"_namespace":null},{"id":11627,"version":2,"created":1554945059000,"modified":1554945063000,"deprecated":false,"name":"Serine/arginine-rich splicing factor 10","accession":"O75494","gene":"SRSF10","description":"Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). 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The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.0281176762191966,"antibodyCount":156,"monoclonalCount":6,"pubmedCount":null,"jensenScore":104.724235,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":43.01311936865416,"pubTatorScore":1.5843475214145744,"self":"https://pharos.nih.gov/idg/api/v1/targets(11630)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/publications"},"_namespace":null},{"id":11631,"version":2,"created":1554945080000,"modified":1554945083000,"deprecated":false,"name":"Carbonic anhydrase-related protein 11","accession":"O75493","gene":"CA11","description":"Does not have a catalytic activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7800792483945788,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.424801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.111340577582123,"pubTatorScore":1.4478468187641966,"self":"https://pharos.nih.gov/idg/api/v1/targets(11631)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/publications"},"_namespace":null},{"id":11632,"version":2,"created":1554945084000,"modified":1554945088000,"deprecated":false,"name":"Myb-related protein B","accession":"P10244","gene":"MYBL2","description":"Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. 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In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.","idgFamily":"Nuclear Receptor","idgTDL":"Tclin","novelty":-2.973389116870858,"antibodyCount":562,"monoclonalCount":210,"pubmedCount":null,"jensenScore":919.309061,"patentCount":71249,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":55.97662471320314,"pubTatorScore":3.0252598546534926,"self":"https://pharos.nih.gov/idg/api/v1/targets(11691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":682,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/properties"},"_links":{"count":1235,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/links"},"_synonyms":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/synonyms"},"_publications":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/publications"},"_namespace":null},{"id":11692,"version":3,"created":1554945754000,"modified":1555040198000,"deprecated":false,"name":"Myosin-9","accession":"P35579","gene":"MYH9","description":"Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. 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For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. 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Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). 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Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.2065798310592153,"antibodyCount":264,"monoclonalCount":28,"pubmedCount":null,"jensenScore":1755.9076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.80867750584238,"pubTatorScore":3.1812251367572446,"self":"https://pharos.nih.gov/idg/api/v1/targets(11744)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/properties"},"_links":{"count":1825,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/synonyms"},"_publications":{"count":609,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/publications"},"_namespace":null},{"id":11745,"version":2,"created":1554946510000,"modified":1554946510000,"deprecated":false,"name":"Endogenous retrovirus group K member 10 Pro protein","accession":"P10265","gene":"ERVK-10","description":"Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. 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May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-1.70130823174566,"antibodyCount":273,"monoclonalCount":47,"pubmedCount":null,"jensenScore":47.147374,"patentCount":9777,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.86343495481168,"pubTatorScore":1.4141109355235524,"self":"https://pharos.nih.gov/idg/api/v1/targets(11820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/publications"},"_namespace":null},{"id":11821,"version":2,"created":1554947263000,"modified":1554947267000,"deprecated":false,"name":"Claudin-4","accession":"O14493","gene":"CLDN4","description":"Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. 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May be involved in cell adhesion and in cell-cell interactions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7785795021021387,"antibodyCount":94,"monoclonalCount":5,"pubmedCount":null,"jensenScore":65.051167,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.5409749422266534,"self":"https://pharos.nih.gov/idg/api/v1/targets(11822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/publications"},"_namespace":null},{"id":11823,"version":2,"created":1554947273000,"modified":1554947286000,"deprecated":false,"name":"Cadherin-1","accession":"P12830","gene":"CDH1","description":"E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. 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Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. 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Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.237238185724665,"antibodyCount":201,"monoclonalCount":28,"pubmedCount":null,"jensenScore":155.111391,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":30.122619771844604,"pubTatorScore":2.1045679194417355,"self":"https://pharos.nih.gov/idg/api/v1/targets(11826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/publications"},"_namespace":null},{"id":11827,"version":2,"created":1554947301000,"modified":1554947305000,"deprecated":false,"name":"EH domain-containing protein 4","accession":"Q9H223","gene":"EHD4","description":"ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. 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Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1472836485833644,"antibodyCount":55,"monoclonalCount":12,"pubmedCount":null,"jensenScore":13.641243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.93291096447332,"pubTatorScore":1.2216939220962266,"self":"https://pharos.nih.gov/idg/api/v1/targets(11829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/publications"},"_namespace":null},{"id":11830,"version":4,"created":1554947315000,"modified":1555040285000,"deprecated":false,"name":"Aromatase","accession":"P11511","gene":"CYP19A1","description":"Catalyzes the formation of aromatic C18 estrogens from C19 androgens.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.38322000907216,"antibodyCount":449,"monoclonalCount":47,"pubmedCount":null,"jensenScore":2408.952882,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":45.301284678179336,"pubTatorScore":3.1787955068929907,"self":"https://pharos.nih.gov/idg/api/v1/targets(11830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/properties"},"_links":{"count":2584,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/links"},"_synonyms":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/synonyms"},"_publications":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/publications"},"_namespace":null},{"id":11831,"version":3,"created":1554947696000,"modified":1555040291000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 2","accession":"Q9H1P3","gene":"OSBPL2","description":"Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). 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Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.488117975313895,"antibodyCount":464,"monoclonalCount":102,"pubmedCount":null,"jensenScore":287.465941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.19240939722766,"pubTatorScore":2.321139677248616,"self":"https://pharos.nih.gov/idg/api/v1/targets(12000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/synonyms"},"_publications":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/publications"},"_namespace":null}]}
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In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2934657010413577,"antibodyCount":321,"monoclonalCount":26,"pubmedCount":null,"jensenScore":191.951961,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":42.74291818328906,"pubTatorScore":1.7456862006926375,"self":"https://pharos.nih.gov/idg/api/v1/targets(12005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":501,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/properties"},"_links":{"count":1346,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/publications"},"_namespace":null},{"id":12006,"version":2,"created":1554948937000,"modified":1554948940000,"deprecated":false,"name":"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial","accession":"Q9H8M1","gene":"COQ10B","description":"Required for the function of coenzyme Q in the respiratory chain. 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May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). 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Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8064438272154788,"antibodyCount":200,"monoclonalCount":20,"pubmedCount":null,"jensenScore":70.523532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.86891203533424,"pubTatorScore":2.3039181055897755,"self":"https://pharos.nih.gov/idg/api/v1/targets(12032)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":503,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/properties"},"_links":{"count":1221,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/publications"},"_namespace":null},{"id":12033,"version":3,"created":1554949058000,"modified":1555040407000,"deprecated":false,"name":"Exosome complex component RRP42","accession":"Q15024","gene":"EXOSC7","description":"Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8309092878204924,"antibodyCount":161,"monoclonalCount":80,"pubmedCount":null,"jensenScore":5.933013,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":34.33723666116247,"pubTatorScore":0.49202831431991734,"self":"https://pharos.nih.gov/idg/api/v1/targets(12033)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/publications"},"_namespace":null},{"id":12034,"version":2,"created":1554949063000,"modified":1554949067000,"deprecated":false,"name":"Alpha-internexin","accession":"Q16352","gene":"INA","description":"Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0267852961886526,"antibodyCount":361,"monoclonalCount":113,"pubmedCount":null,"jensenScore":107.385663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.952871794240636,"pubTatorScore":2.303376070821689,"self":"https://pharos.nih.gov/idg/api/v1/targets(12034)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/publications"},"_namespace":null},{"id":12035,"version":3,"created":1554949068000,"modified":1555040408000,"deprecated":false,"name":"Proepiregulin","accession":"O14944","gene":"EREG","description":"Ligand of the EGF receptor/EGFR and ERBB4. 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Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.282263775411276,"antibodyCount":187,"monoclonalCount":66,"pubmedCount":null,"jensenScore":183.262588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.318769377801196,"pubTatorScore":1.8179670614710959,"self":"https://pharos.nih.gov/idg/api/v1/targets(12035)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/publications"},"_namespace":null},{"id":12036,"version":2,"created":1554949072000,"modified":1554949075000,"deprecated":false,"name":"Multimerin-2","accession":"Q9H8L6","gene":"MMRN2","description":"Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7312753147172617,"antibodyCount":82,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.931774,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.719264726142658,"pubTatorScore":1.038910203988243,"self":"https://pharos.nih.gov/idg/api/v1/targets(12036)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/publications"},"_namespace":null},{"id":12037,"version":3,"created":1554949076000,"modified":1555040410000,"deprecated":false,"name":"Amyloid-beta A4 precursor protein-binding family A member 3","accession":"O96018","gene":"APBA3","description":"May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.185782646071723,"antibodyCount":125,"monoclonalCount":1,"pubmedCount":null,"jensenScore":15.270277,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":34.11346350478952,"pubTatorScore":1.14830138191507,"self":"https://pharos.nih.gov/idg/api/v1/targets(12037)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/publications"},"_namespace":null},{"id":12038,"version":2,"created":1554949079000,"modified":1554949082000,"deprecated":false,"name":"Mdm2-binding protein","accession":"Q96DY7","gene":"MTBP","description":"Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3113081172210261,"antibodyCount":170,"monoclonalCount":31,"pubmedCount":null,"jensenScore":18.014851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.715290887714218,"pubTatorScore":1.1279527564403917,"self":"https://pharos.nih.gov/idg/api/v1/targets(12038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/publications"},"_namespace":null},{"id":12039,"version":2,"created":1554949083000,"modified":1554949088000,"deprecated":false,"name":"116 kDa U5 small nuclear ribonucleoprotein component","accession":"Q15029","gene":"EFTUD2","description":"Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5728686446651288,"antibodyCount":177,"monoclonalCount":3,"pubmedCount":null,"jensenScore":38.572322,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.33675851688802,"pubTatorScore":1.3597383146746023,"self":"https://pharos.nih.gov/idg/api/v1/targets(12039)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/publications"},"_namespace":null},{"id":12040,"version":2,"created":1554949089000,"modified":1554949116000,"deprecated":false,"name":"Serine/threonine-protein kinase Chk2","accession":"O96017","gene":"CHEK2","description":"Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.003037631023601,"antibodyCount":1374,"monoclonalCount":370,"pubmedCount":null,"jensenScore":978.735345,"patentCount":45013,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":57.844527465750296,"pubTatorScore":2.94709437054675,"self":"https://pharos.nih.gov/idg/api/v1/targets(12040)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/properties"},"_links":{"count":1554,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/links"},"_synonyms":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/synonyms"},"_publications":{"count":483,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/publications"},"_namespace":null},{"id":12041,"version":3,"created":1554949118000,"modified":1555040413000,"deprecated":false,"name":"Dynein light chain 4, axonemal","accession":"O96015","gene":"DNAL4","description":"Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5481846073602816,"antibodyCount":171,"monoclonalCount":58,"pubmedCount":null,"jensenScore":3.316667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":30.09481797261799,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(12041)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/publications"},"_namespace":null},{"id":12042,"version":2,"created":1554949121000,"modified":1554949125000,"deprecated":false,"name":"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1","accession":"Q15027","gene":"ACAP1","description":"GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1697260361728705,"antibodyCount":170,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.441871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.717243295581323,"pubTatorScore":1.22587295572761,"self":"https://pharos.nih.gov/idg/api/v1/targets(12042)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/publications"},"_namespace":null},{"id":12043,"version":2,"created":1554949126000,"modified":1554949130000,"deprecated":false,"name":"Pumilio homolog 2","accession":"Q8TB72","gene":"PUM2","description":"Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.381336687575311,"antibodyCount":373,"monoclonalCount":127,"pubmedCount":null,"jensenScore":22.912999,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.983826363788886,"pubTatorScore":1.3995058021953481,"self":"https://pharos.nih.gov/idg/api/v1/targets(12043)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/properties"},"_links":{"count":1087,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/publications"},"_namespace":null},{"id":12044,"version":3,"created":1554949131000,"modified":1555040414000,"deprecated":false,"name":"Cytochrome P450 2W1","accession":"Q8TAV3","gene":"CYP2W1","description":"Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4417260613318108,"antibodyCount":127,"monoclonalCount":16,"pubmedCount":null,"jensenScore":30.714423,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.567347031406364,"pubTatorScore":1.505180092883769,"self":"https://pharos.nih.gov/idg/api/v1/targets(12044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/properties"},"_links":{"count":822,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/publications"},"_namespace":null},{"id":12045,"version":2,"created":1554949135000,"modified":1554949138000,"deprecated":false,"name":"Protein NDNF","accession":"Q8TB73","gene":"NDNF","description":"Promotes matrix assembly and cell adhesiveness (By similarity). 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Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4884393394601965,"antibodyCount":135,"monoclonalCount":22,"pubmedCount":null,"jensenScore":28.910767,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.81178799835381,"pubTatorScore":0.7668464045529908,"self":"https://pharos.nih.gov/idg/api/v1/targets(12063)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/publications"},"_namespace":null},{"id":12064,"version":2,"created":1554949270000,"modified":1554949273000,"deprecated":false,"name":"Sorting nexin-17","accession":"Q15036","gene":"SNX17","description":"Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.194138059568025,"antibodyCount":101,"monoclonalCount":8,"pubmedCount":null,"jensenScore":18.307999,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.46246629067845,"pubTatorScore":1.3388266814033123,"self":"https://pharos.nih.gov/idg/api/v1/targets(12064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/properties"},"_links":{"count":1131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/publications"},"_namespace":null},{"id":12065,"version":2,"created":1554949273000,"modified":1554949277000,"deprecated":false,"name":"Translocating chain-associated membrane protein 2","accession":"Q15035","gene":"TRAM2","description":"Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.871884052184183,"antibodyCount":124,"monoclonalCount":13,"pubmedCount":null,"jensenScore":7.172592,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.04611699925198,"pubTatorScore":0.21967174306669981,"self":"https://pharos.nih.gov/idg/api/v1/targets(12065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/publications"},"_namespace":null},{"id":12066,"version":3,"created":1554949278000,"modified":1555040426000,"deprecated":false,"name":"Laminin subunit alpha-4","accession":"Q16363","gene":"LAMA4","description":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1957329570159203,"antibodyCount":203,"monoclonalCount":41,"pubmedCount":null,"jensenScore":14.126024,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.211482507924075,"pubTatorScore":1.6305228907040605,"self":"https://pharos.nih.gov/idg/api/v1/targets(12066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/publications"},"_namespace":null},{"id":12067,"version":3,"created":1554949284000,"modified":1555040428000,"deprecated":false,"name":"Probable E3 ubiquitin-protein ligase HERC3","accession":"Q15034","gene":"HERC3","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6454846485051143,"antibodyCount":175,"monoclonalCount":48,"pubmedCount":null,"jensenScore":4.43659,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.029015511527053,"pubTatorScore":0.6548180725420142,"self":"https://pharos.nih.gov/idg/api/v1/targets(12067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/publications"},"_namespace":null},{"id":12068,"version":3,"created":1554949287000,"modified":1555040430000,"deprecated":false,"name":"Tripartite motif-containing protein 44","accession":"Q96DX7","gene":"TRIM44","description":"May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.700159427021992,"antibodyCount":187,"monoclonalCount":99,"pubmedCount":null,"jensenScore":49.027313,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":45,"knowledgeAvailability":39.570792622048096,"pubTatorScore":1.1290497061042186,"self":"https://pharos.nih.gov/idg/api/v1/targets(12068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/publications"},"_namespace":null},{"id":12069,"version":3,"created":1554949292000,"modified":1555040432000,"deprecated":false,"name":"Aryl hydrocarbon receptor nuclear translocator-like protein 1","accession":"O00327","gene":"ARNTL","description":"Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.8354776239795623,"antibodyCount":330,"monoclonalCount":74,"pubmedCount":null,"jensenScore":672.891817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":50.701191464482314,"pubTatorScore":2.371301331661206,"self":"https://pharos.nih.gov/idg/api/v1/targets(12069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/properties"},"_links":{"count":1147,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/links"},"_synonyms":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/publications"},"_namespace":null},{"id":12070,"version":2,"created":1554949298000,"modified":1554949304000,"deprecated":false,"name":"Histone-lysine N-methyltransferase NSD2","accession":"O96028","gene":"NSD2","description":"Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-2.4333645570685363,"antibodyCount":123,"monoclonalCount":12,"pubmedCount":null,"jensenScore":275.226599,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.9956247670179872,"self":"https://pharos.nih.gov/idg/api/v1/targets(12070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/properties"},"_links":{"count":1263,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/links"},"_synonyms":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/publications"},"_namespace":null},{"id":12071,"version":4,"created":1554949306000,"modified":1555040434000,"deprecated":false,"name":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform","accession":"O00329","gene":"PIK3CD","description":"Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.85064230483579,"antibodyCount":423,"monoclonalCount":64,"pubmedCount":null,"jensenScore":709.242269,"patentCount":6395,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":51.77633472897743,"pubTatorScore":3.460271530483198,"self":"https://pharos.nih.gov/idg/api/v1/targets(12071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":605,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/properties"},"_links":{"count":1589,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/publications"},"_namespace":null},{"id":12072,"version":2,"created":1554949463000,"modified":1554949463000,"deprecated":false,"name":"Testis-expressed protein 48","accession":"A0A1B0GUV7","gene":"TEX48","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/properties"},"_links":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/publications"},"_namespace":null},{"id":12073,"version":2,"created":1554949464000,"modified":1554949466000,"deprecated":false,"name":"Receptor-transporting protein 4","accession":"Q96DX8","gene":"RTP4","description":"Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6840716803371287,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.577311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.184938407887106,"pubTatorScore":0.3232846968239614,"self":"https://pharos.nih.gov/idg/api/v1/targets(12073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/publications"},"_namespace":null},{"id":12074,"version":2,"created":1554949467000,"modified":1554949469000,"deprecated":false,"name":"Proline-rich protein 7","accession":"Q8TB68","gene":"PRR7","description":"Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). 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Also mediates cellular uptake of nontransferrin-bound iron.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.6871943025610714,"antibodyCount":117,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.462871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.00617902050749,"pubTatorScore":1.4603938439627608,"self":"https://pharos.nih.gov/idg/api/v1/targets(12093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/publications"},"_namespace":null},{"id":12094,"version":3,"created":1554949537000,"modified":1555040446000,"deprecated":false,"name":"Rab3 GTPase-activating protein catalytic subunit","accession":"Q15042","gene":"RAB3GAP1","description":"Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4065351556758678,"antibodyCount":104,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.028538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.61391170343331,"pubTatorScore":1.4690243608989935,"self":"https://pharos.nih.gov/idg/api/v1/targets(12094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/properties"},"_links":{"count":1274,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/publications"},"_namespace":null},{"id":12095,"version":2,"created":1554949544000,"modified":1554949546000,"deprecated":false,"name":"Proline-rich protein 4","accession":"Q16378","gene":"PRR4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.643914264039466,"antibodyCount":12,"monoclonalCount":4,"pubmedCount":null,"jensenScore":49.405601,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.907348014033623,"pubTatorScore":1.1798872919000007,"self":"https://pharos.nih.gov/idg/api/v1/targets(12095)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/publications"},"_namespace":null},{"id":12096,"version":2,"created":1554949546000,"modified":1554949549000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 6-interacting protein 1","accession":"Q15041","gene":"ARL6IP1","description":"Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.020433643873573,"antibodyCount":217,"monoclonalCount":16,"pubmedCount":null,"jensenScore":14.287801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.199070993732924,"pubTatorScore":0.9230465200336901,"self":"https://pharos.nih.gov/idg/api/v1/targets(12096)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/publications"},"_namespace":null},{"id":12097,"version":2,"created":1554949550000,"modified":1554949552000,"deprecated":false,"name":"Homeobox protein Nkx-2.3","accession":"Q8TAU0","gene":"NKX2-3","description":"Transcription factor.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4730144151912985,"antibodyCount":63,"monoclonalCount":6,"pubmedCount":null,"jensenScore":30.674484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.560228242089867,"pubTatorScore":1.2410435135186657,"self":"https://pharos.nih.gov/idg/api/v1/targets(12097)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/properties"},"_links":{"count":504,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/publications"},"_namespace":null},{"id":12098,"version":2,"created":1554949552000,"modified":1554949555000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 14","accession":"Q15048","gene":"LRRC14","description":"Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.14483356559667326,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.7625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.915535001987042,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12098)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/publications"},"_namespace":null},{"id":12099,"version":3,"created":1554949555000,"modified":1555040448000,"deprecated":false,"name":"Hepatocyte growth factor-regulated tyrosine kinase substrate","accession":"O14964","gene":"HGS","description":"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7664302887290226,"antibodyCount":379,"monoclonalCount":76,"pubmedCount":null,"jensenScore":560.075163,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":47.84510755398793,"pubTatorScore":1.7099258269512612,"self":"https://pharos.nih.gov/idg/api/v1/targets(12099)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/synonyms"},"_publications":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/publications"},"_namespace":null},{"id":12100,"version":3,"created":1554949560000,"modified":1555040450000,"deprecated":false,"name":"Histone-lysine N-methyltransferase SETDB1","accession":"Q15047","gene":"SETDB1","description":"Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-2.25204391715242,"antibodyCount":274,"monoclonalCount":76,"pubmedCount":null,"jensenScore":181.608916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":43.298845317809324,"pubTatorScore":1.8205644200082693,"self":"https://pharos.nih.gov/idg/api/v1/targets(12100)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/publications"},"_namespace":null},{"id":12101,"version":3,"created":1554949567000,"modified":1555040456000,"deprecated":false,"name":"MANSC domain-containing protein 1","accession":"Q9H8J5","gene":"MANSC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.1646114427940486,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.56908,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":87,"knowledgeAvailability":28.846046560876356,"pubTatorScore":-0.4623357679583681,"self":"https://pharos.nih.gov/idg/api/v1/targets(12101)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/publications"},"_namespace":null},{"id":12102,"version":3,"created":1554949572000,"modified":1555040457000,"deprecated":false,"name":"Ras-related protein Rab-7L1","accession":"O14966","gene":"RAB29","description":"Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1606845763872555,"antibodyCount":122,"monoclonalCount":28,"pubmedCount":null,"jensenScore":15.337606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.66650738461715,"pubTatorScore":1.1374621017897004,"self":"https://pharos.nih.gov/idg/api/v1/targets(12102)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/publications"},"_namespace":null},{"id":12103,"version":3,"created":1554949577000,"modified":1555040459000,"deprecated":false,"name":"Lysine--tRNA ligase","accession":"Q15046","gene":"KARS","description":"(Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.457160884891776,"antibodyCount":150,"monoclonalCount":37,"pubmedCount":null,"jensenScore":282.493895,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":48.121272367966085,"pubTatorScore":2.14336823147521,"self":"https://pharos.nih.gov/idg/api/v1/targets(12103)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/properties"},"_links":{"count":1257,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/publications"},"_namespace":null},{"id":12104,"version":4,"created":1554949597000,"modified":1555040466000,"deprecated":false,"name":"Aurora kinase A","accession":"O14965","gene":"AURKA","description":"Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.083472359245035,"antibodyCount":702,"monoclonalCount":179,"pubmedCount":null,"jensenScore":1158.019468,"patentCount":76823,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":56.538258505540014,"pubTatorScore":2.982113826149861,"self":"https://pharos.nih.gov/idg/api/v1/targets(12104)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/properties"},"_links":{"count":2492,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/links"},"_synonyms":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/synonyms"},"_publications":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/publications"},"_namespace":null},{"id":12105,"version":2,"created":1554949859000,"modified":1554949862000,"deprecated":false,"name":"Solute carrier family 25 member 38","accession":"Q96DW6","gene":"SLC25A38","description":"Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.1211361886859879,"antibodyCount":74,"monoclonalCount":5,"pubmedCount":null,"jensenScore":12.181746,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.181745995601037,"pubTatorScore":1.111175074520842,"self":"https://pharos.nih.gov/idg/api/v1/targets(12105)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/publications"},"_namespace":null},{"id":12106,"version":3,"created":1554949863000,"modified":1555040472000,"deprecated":false,"name":"Sulfotransferase 1C2","accession":"O00338","gene":"SULT1C2","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.256366392771483,"antibodyCount":167,"monoclonalCount":55,"pubmedCount":null,"jensenScore":118.686634,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.00383802766088,"pubTatorScore":1.139107055836804,"self":"https://pharos.nih.gov/idg/api/v1/targets(12106)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/publications"},"_namespace":null},{"id":12107,"version":2,"created":1554949867000,"modified":1554949870000,"deprecated":false,"name":"Endonuclease 8-like 3","accession":"Q8TAT5","gene":"NEIL3","description":"DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. 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Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). 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Induces apoptosis (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5824256825977825,"antibodyCount":237,"monoclonalCount":83,"pubmedCount":null,"jensenScore":49.938896,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.96822968085616,"pubTatorScore":1.650313294255163,"self":"https://pharos.nih.gov/idg/api/v1/targets(12147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/publications"},"_namespace":null},{"id":12148,"version":3,"created":1554950074000,"modified":1555040507000,"deprecated":false,"name":"Protein Wnt-9a","accession":"O14904","gene":"WNT9A","description":"Ligand for members of the frizzled family of seven transmembrane receptors. 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Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). 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May participate in cell junction dynamics in Sertoli cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9171893623760083,"antibodyCount":179,"monoclonalCount":7,"pubmedCount":null,"jensenScore":6.856617,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":40.65500302860759,"pubTatorScore":0.38123208067574926,"self":"https://pharos.nih.gov/idg/api/v1/targets(12156)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/publications"},"_namespace":null},{"id":12157,"version":2,"created":1554950118000,"modified":1554950123000,"deprecated":false,"name":"Peroxisomal acyl-coenzyme A oxidase 1","accession":"Q15067","gene":"ACOX1","description":"Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. 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Required for axon guidance and major tract formation in the developing forebrain. 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May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4976754566429098,"antibodyCount":186,"monoclonalCount":2,"pubmedCount":null,"jensenScore":34.448583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":32.17981696135905,"pubTatorScore":1.1142605720631276,"self":"https://pharos.nih.gov/idg/api/v1/targets(12260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/publications"},"_namespace":null},{"id":12261,"version":3,"created":1554951016000,"modified":1555040589000,"deprecated":false,"name":"Membrane protein FAM174A","accession":"Q8TBP5","gene":"FAM174A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2973957115879465,"antibodyCount":24,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.764881,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":44,"knowledgeAvailability":27.322767855200386,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(12261)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/publications"},"_namespace":null},{"id":12262,"version":3,"created":1554951019000,"modified":1555040591000,"deprecated":false,"name":"SAGA-associated factor 29","accession":"Q96ES7","gene":"SGF29","description":"Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.7823450037709536,"antibodyCount":84,"monoclonalCount":0,"pubmedCount":null,"jensenScore":590.134005,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":39,"knowledgeAvailability":0.0,"pubTatorScore":0.8034246106311692,"self":"https://pharos.nih.gov/idg/api/v1/targets(12262)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/publications"},"_namespace":null},{"id":12263,"version":2,"created":1554951022000,"modified":1554951024000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 3","accession":"Q96ES6","gene":"MFSD3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.461538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.212894543695736,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/properties"},"_links":{"count":777,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/publications"},"_namespace":null},{"id":12264,"version":2,"created":1554951025000,"modified":1554951028000,"deprecated":false,"name":"Solute carrier family 25 member 40","accession":"Q8TBP6","gene":"SLC25A40","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":-1.7510806593784407,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":56.302835,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.863686654831845,"pubTatorScore":1.0321108066990077,"self":"https://pharos.nih.gov/idg/api/v1/targets(12264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/publications"},"_namespace":null},{"id":12265,"version":3,"created":1554951028000,"modified":1555040594000,"deprecated":false,"name":"Interleukin-17 receptor A","accession":"Q96F46","gene":"IL17RA","description":"Receptor for IL17A (PubMed:17911633, PubMed:9367539). 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Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.182862525381674,"antibodyCount":481,"monoclonalCount":257,"pubmedCount":null,"jensenScore":122.692102,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":56,"knowledgeAvailability":38.20005120630001,"pubTatorScore":1.955777173065571,"self":"https://pharos.nih.gov/idg/api/v1/targets(12265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/publications"},"_namespace":null},{"id":12266,"version":2,"created":1554951035000,"modified":1554951048000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase FKBP1B","accession":"P68106","gene":"FKBP1B","description":"Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. 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The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 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F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8186547078643056,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":63.471945,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.39630241439839564,"self":"https://pharos.nih.gov/idg/api/v1/targets(12276)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/publications"},"_namespace":null},{"id":12277,"version":3,"created":1554951093000,"modified":1555040604000,"deprecated":false,"name":"Beta-arrestin-2","accession":"P32121","gene":"ARRB2","description":"Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. 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These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.291449935588867,"antibodyCount":589,"monoclonalCount":84,"pubmedCount":null,"jensenScore":187.343661,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.328221521805446,"pubTatorScore":2.8744753652763744,"self":"https://pharos.nih.gov/idg/api/v1/targets(12329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/properties"},"_links":{"count":1552,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/links"},"_synonyms":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/synonyms"},"_publications":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/publications"},"_namespace":null},{"id":12330,"version":3,"created":1554951316000,"modified":1555040645000,"deprecated":false,"name":"HSPB1-associated protein 1","accession":"Q96EW2","gene":"HSPBAP1","description":"May play a role in cellular stress response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.521078566855061,"antibodyCount":155,"monoclonalCount":22,"pubmedCount":null,"jensenScore":31.630562,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.883811963364046,"pubTatorScore":1.1274334737769847,"self":"https://pharos.nih.gov/idg/api/v1/targets(12330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/publications"},"_namespace":null},{"id":12331,"version":2,"created":1554951321000,"modified":1554951321000,"deprecated":false,"name":"Uncharacterized protein C9orf170","accession":"A2RU37","gene":"C9orf170","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12331)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/properties"},"_links":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/publications"},"_namespace":null},{"id":12332,"version":2,"created":1554951321000,"modified":1554951321000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 18","accession":"D6R9N7","gene":"USP17L18","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.3366485642104666,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12332)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/properties"},"_links":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/publications"},"_namespace":null},{"id":12333,"version":2,"created":1554951321000,"modified":1554951324000,"deprecated":false,"name":"Prestin","accession":"P58743","gene":"SLC26A5","description":"Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-3.1040087128936196,"antibodyCount":99,"monoclonalCount":10,"pubmedCount":null,"jensenScore":1262.97074,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.008499376827803,"pubTatorScore":1.6988045152982945,"self":"https://pharos.nih.gov/idg/api/v1/targets(12333)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/publications"},"_namespace":null},{"id":12334,"version":2,"created":1554951325000,"modified":1554951328000,"deprecated":false,"name":"Meiosis 1 arrest protein","accession":"Q8TC57","gene":"M1AP","description":"Required for meiosis I progression during spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4784977848720299,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.533766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.060571133865814,"pubTatorScore":0.32451106865589924,"self":"https://pharos.nih.gov/idg/api/v1/targets(12334)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/publications"},"_namespace":null},{"id":12335,"version":2,"created":1554951328000,"modified":1554951329000,"deprecated":false,"name":"Immunoglobulin kappa variable 2-40","accession":"A0A087WW87","gene":"IGKV2-40","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.9616895818744866,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12335)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/publications"},"_namespace":null},{"id":12336,"version":2,"created":1554951329000,"modified":1554951332000,"deprecated":false,"name":"Piwi-like protein 2","accession":"Q8TC59","gene":"PIWIL2","description":"Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2046045781228267,"antibodyCount":204,"monoclonalCount":12,"pubmedCount":null,"jensenScore":154.806637,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.8248314882723,"pubTatorScore":1.7962911724941337,"self":"https://pharos.nih.gov/idg/api/v1/targets(12336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/publications"},"_namespace":null},{"id":12337,"version":3,"created":1554951333000,"modified":1555040647000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit alpha-6","accession":"Q16445","gene":"GABRA6","description":"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.307945752433831,"antibodyCount":145,"monoclonalCount":1,"pubmedCount":null,"jensenScore":19.330286,"patentCount":777,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":26.02947941923013,"pubTatorScore":1.5009237466787857,"self":"https://pharos.nih.gov/idg/api/v1/targets(12337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/publications"},"_namespace":null},{"id":12338,"version":2,"created":1554951376000,"modified":1554951379000,"deprecated":false,"name":"Procollagen C-endopeptidase enhancer 1","accession":"Q15113","gene":"PCOLCE","description":"C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7384894755016886,"antibodyCount":153,"monoclonalCount":34,"pubmedCount":null,"jensenScore":56.578185,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.958778801514576,"pubTatorScore":1.644465936356852,"self":"https://pharos.nih.gov/idg/api/v1/targets(12338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/publications"},"_namespace":null},{"id":12339,"version":2,"created":1554951380000,"modified":1554951385000,"deprecated":false,"name":"Inactive phospholipase C-like protein 1","accession":"Q15111","gene":"PLCL1","description":"Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2252611993026203,"antibodyCount":97,"monoclonalCount":2,"pubmedCount":null,"jensenScore":167.932251,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.17620006126883,"pubTatorScore":1.8223339952553657,"self":"https://pharos.nih.gov/idg/api/v1/targets(12339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/publications"},"_namespace":null},{"id":12340,"version":4,"created":1554951385000,"modified":1555040648000,"deprecated":false,"name":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial","accession":"Q15118","gene":"PDK1","description":"Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.0915553026783293,"antibodyCount":601,"monoclonalCount":108,"pubmedCount":null,"jensenScore":10.286604,"patentCount":42947,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":45.84719964610428,"pubTatorScore":2.5438940187102617,"self":"https://pharos.nih.gov/idg/api/v1/targets(12340)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/publications"},"_namespace":null},{"id":12341,"version":3,"created":1554951427000,"modified":1555040649000,"deprecated":false,"name":"POC1 centriolar protein homolog B","accession":"Q8TC44","gene":"POC1B","description":"Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). 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Is not required for association of CNOT7 to the CCR4-NOT complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.28879554286609027,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.694444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":30.657800079483128,"pubTatorScore":0.054357534588902724,"self":"https://pharos.nih.gov/idg/api/v1/targets(12452)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/publications"},"_namespace":null},{"id":12453,"version":3,"created":1554951951000,"modified":1555040726000,"deprecated":false,"name":"Lys-63-specific deubiquitinase BRCC36","accession":"P46736","gene":"BRCC3","description":"Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1521529707047846,"antibodyCount":225,"monoclonalCount":59,"pubmedCount":null,"jensenScore":13.427387,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.26500891134578,"pubTatorScore":1.3270715100666506,"self":"https://pharos.nih.gov/idg/api/v1/targets(12453)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/publications"},"_namespace":null},{"id":12454,"version":3,"created":1554951955000,"modified":1555040727000,"deprecated":false,"name":"RecQ-mediated genome instability protein 1","accession":"Q9H9A7","gene":"RMI1","description":"Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. 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Within the BLM complex, required for BLM and TOP3A stability.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5950980668881543,"antibodyCount":118,"monoclonalCount":5,"pubmedCount":null,"jensenScore":41.287063,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.897298980911685,"pubTatorScore":1.5407092475299726,"self":"https://pharos.nih.gov/idg/api/v1/targets(12454)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/publications"},"_namespace":null},{"id":12455,"version":3,"created":1554951960000,"modified":1555040728000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 40","accession":"Q9H9A6","gene":"LRRC40","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8287076237783628,"antibodyCount":87,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.102564,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.503458955088117,"pubTatorScore":-1.3010299956639813,"self":"https://pharos.nih.gov/idg/api/v1/targets(12455)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/properties"},"_links":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/publications"},"_namespace":null},{"id":12456,"version":2,"created":1554951963000,"modified":1554951966000,"deprecated":false,"name":"Zinc finger CCHC domain-containing protein 10","accession":"Q8TBK6","gene":"ZCCHC10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5477023284263104,"antibodyCount":22,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.283333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.039608593222656,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12456)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/publications"},"_namespace":null},{"id":12457,"version":2,"created":1554951967000,"modified":1554951970000,"deprecated":false,"name":"Molybdenum cofactor sulfurase","accession":"Q96EN8","gene":"MOCOS","description":"Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.104851267341045,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":13.074248,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.7301930491293,"pubTatorScore":1.119109174607437,"self":"https://pharos.nih.gov/idg/api/v1/targets(12457)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/publications"},"_namespace":null},{"id":12458,"version":2,"created":1554951971000,"modified":1554951978000,"deprecated":false,"name":"Matrix Gla protein","accession":"P08493","gene":"MGP","description":"Associates with the organic matrix of bone and cartilage. 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Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.6622034179391076,"antibodyCount":526,"monoclonalCount":114,"pubmedCount":null,"jensenScore":474.362556,"patentCount":42469,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":42.03888251922993,"pubTatorScore":2.461222402409432,"self":"https://pharos.nih.gov/idg/api/v1/targets(12460)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":570,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/properties"},"_links":{"count":1954,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/synonyms"},"_publications":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/publications"},"_namespace":null},{"id":12461,"version":4,"created":1554952231000,"modified":1555040734000,"deprecated":false,"name":"Substance-K receptor","accession":"P21452","gene":"TACR2","description":"This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.565774515951548,"antibodyCount":189,"monoclonalCount":4,"pubmedCount":null,"jensenScore":318.325819,"patentCount":13616,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.37132924895475,"pubTatorScore":2.3657483917672932,"self":"https://pharos.nih.gov/idg/api/v1/targets(12461)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/properties"},"_links":{"count":1448,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/publications"},"_namespace":null},{"id":12462,"version":2,"created":1554952373000,"modified":1554952378000,"deprecated":false,"name":"Dual specificity mitogen-activated protein kinase kinase 3","accession":"P46734","gene":"MAP2K3","description":"Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.3530133576641026,"antibodyCount":1060,"monoclonalCount":478,"pubmedCount":null,"jensenScore":190.893144,"patentCount":12683,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.24146372751445,"pubTatorScore":1.8241941306318155,"self":"https://pharos.nih.gov/idg/api/v1/targets(12462)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/publications"},"_namespace":null},{"id":12463,"version":2,"created":1554952380000,"modified":1554952382000,"deprecated":false,"name":"A-kinase anchor protein 3","accession":"O75969","gene":"AKAP3","description":"May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.366350390509536,"antibodyCount":139,"monoclonalCount":5,"pubmedCount":null,"jensenScore":24.006425,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.674460894186037,"pubTatorScore":1.3760882103404002,"self":"https://pharos.nih.gov/idg/api/v1/targets(12463)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/publications"},"_namespace":null},{"id":12464,"version":2,"created":1554952383000,"modified":1554952386000,"deprecated":false,"name":"ATP synthase subunit g, mitochondrial","accession":"O75964","gene":"ATP5MG","description":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.27243939533925987,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.148838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4895555325608014,"self":"https://pharos.nih.gov/idg/api/v1/targets(12464)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/properties"},"_links":{"count":1136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/publications"},"_namespace":null},{"id":12465,"version":3,"created":1554952387000,"modified":1555040737000,"deprecated":false,"name":"Thyroid transcription factor 1-associated protein 26","accession":"Q9P031","gene":"CCDC59","description":"Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5583084769504687,"antibodyCount":42,"monoclonalCount":1,"pubmedCount":null,"jensenScore":3.714118,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":35.59912999543629,"pubTatorScore":0.9208187365805955,"self":"https://pharos.nih.gov/idg/api/v1/targets(12465)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/publications"},"_namespace":null},{"id":12466,"version":2,"created":1554952391000,"modified":1554952396000,"deprecated":false,"name":"Triple functional domain protein","accession":"O75962","gene":"TRIO","description":"Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). 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May act as a regulator of adipogenesis (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.0408440835763035,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":103.770594,"patentCount":37881,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.19637339022723,"pubTatorScore":2.274341085184572,"self":"https://pharos.nih.gov/idg/api/v1/targets(12466)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/publications"},"_namespace":null},{"id":12467,"version":3,"created":1554952396000,"modified":1555040738000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4","accession":"Q9P032","gene":"NDUFAF4","description":"Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). 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Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.7937515798673549,"antibodyCount":83,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.875226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.653192629871356,"pubTatorScore":0.5867122869891247,"self":"https://pharos.nih.gov/idg/api/v1/targets(12468)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/publications"},"_namespace":null},{"id":12469,"version":3,"created":1554952409000,"modified":1555040742000,"deprecated":false,"name":"Syndecan-2","accession":"P34741","gene":"SDC2","description":"Cell surface proteoglycan that bears heparan sulfate. 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This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. 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Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.9134622162467925,"antibodyCount":146,"monoclonalCount":20,"pubmedCount":null,"jensenScore":806.623926,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.12551748968496,"pubTatorScore":2.695638041633195,"self":"https://pharos.nih.gov/idg/api/v1/targets(12487)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":477,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/publications"},"_namespace":null},{"id":12488,"version":2,"created":1554952494000,"modified":1554952495000,"deprecated":false,"name":"Testis-specific Y-encoded protein 4","accession":"P0CV99","gene":"TSPY4","description":"Unknown. May be involved in sperm differentiation and proliferation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2521814275057435,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.918518,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.06694654146226692,"self":"https://pharos.nih.gov/idg/api/v1/targets(12488)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/properties"},"_links":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/publications"},"_namespace":null},{"id":12489,"version":2,"created":1554952495000,"modified":1554952495000,"deprecated":false,"name":"Testis-specific Y-encoded protein 3","accession":"P0CV98","gene":"TSPY3","description":"Unknown. May be involved in sperm differentiation and proliferation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9555366790272941,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":88.146199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.184290391894215,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12489)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/properties"},"_links":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/publications"},"_namespace":null},{"id":12490,"version":2,"created":1554952495000,"modified":1554952496000,"deprecated":false,"name":"Paraneoplastic antigen-like protein 8C","accession":"A0A1B0GUJ8","gene":"PNMA8C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/properties"},"_links":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/links"},"_synonyms":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/publications"},"_namespace":null},{"id":12491,"version":3,"created":1554952496000,"modified":1555040748000,"deprecated":false,"name":"Inhibin beta A chain","accession":"P08476","gene":"INHBA","description":"Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.921082668022149,"antibodyCount":319,"monoclonalCount":27,"pubmedCount":null,"jensenScore":76.579612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.626460478734785,"pubTatorScore":2.1975680899531724,"self":"https://pharos.nih.gov/idg/api/v1/targets(12491)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":569,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/synonyms"},"_publications":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/publications"},"_namespace":null},{"id":12492,"version":2,"created":1554952502000,"modified":1554952505000,"deprecated":false,"name":"Arylacetamide deacetylase","accession":"P22760","gene":"AADAC","description":"Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3341824157762991,"antibodyCount":116,"monoclonalCount":22,"pubmedCount":null,"jensenScore":25.603439,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.4159309032468,"pubTatorScore":1.9562634460194184,"self":"https://pharos.nih.gov/idg/api/v1/targets(12492)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/properties"},"_links":{"count":730,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/publications"},"_namespace":null},{"id":12493,"version":4,"created":1554952506000,"modified":1555040751000,"deprecated":false,"name":"Neprilysin","accession":"P08473","gene":"MME","description":"Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.641684359917804,"antibodyCount":1505,"monoclonalCount":1031,"pubmedCount":null,"jensenScore":4375.794389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":44.895560672234154,"pubTatorScore":3.389925144557807,"self":"https://pharos.nih.gov/idg/api/v1/targets(12493)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":668,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/properties"},"_links":{"count":1706,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/links"},"_synonyms":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/synonyms"},"_publications":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/publications"},"_namespace":null},{"id":12494,"version":3,"created":1554952576000,"modified":1555040755000,"deprecated":false,"name":"Fatty acid-binding protein, liver","accession":"P07148","gene":"FABP1","description":"Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.578401008322777,"antibodyCount":411,"monoclonalCount":152,"pubmedCount":null,"jensenScore":448.755749,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.320043003154296,"pubTatorScore":2.469549672128679,"self":"https://pharos.nih.gov/idg/api/v1/targets(12494)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/publications"},"_namespace":null},{"id":12495,"version":2,"created":1554952583000,"modified":1554952586000,"deprecated":false,"name":"Zinc finger protein 703","accession":"Q9H7S9","gene":"ZNF703","description":"Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2137661365302286,"antibodyCount":190,"monoclonalCount":21,"pubmedCount":null,"jensenScore":18.747659,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.786653356414913,"pubTatorScore":1.1785552468864084,"self":"https://pharos.nih.gov/idg/api/v1/targets(12495)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/publications"},"_namespace":null},{"id":12496,"version":3,"created":1554952587000,"modified":1555040756000,"deprecated":false,"name":"Neogenin","accession":"Q92859","gene":"NEO1","description":"Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0746502575229893,"antibodyCount":123,"monoclonalCount":21,"pubmedCount":null,"jensenScore":120.240784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.797785699142445,"pubTatorScore":1.6149310517365645,"self":"https://pharos.nih.gov/idg/api/v1/targets(12496)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/publications"},"_namespace":null},{"id":12497,"version":2,"created":1554952592000,"modified":1554952598000,"deprecated":false,"name":"Interferon regulatory factor 1","accession":"P10914","gene":"IRF1","description":"Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.903145580243671,"antibodyCount":366,"monoclonalCount":69,"pubmedCount":null,"jensenScore":827.710342,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.414395314946695,"pubTatorScore":2.6941043002526324,"self":"https://pharos.nih.gov/idg/api/v1/targets(12497)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":647,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/properties"},"_links":{"count":1241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/synonyms"},"_publications":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/publications"},"_namespace":null},{"id":12498,"version":2,"created":1554952599000,"modified":1554952603000,"deprecated":false,"name":"Caprin-2","accession":"Q6IMN6","gene":"CAPRIN2","description":"Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.869262782451758,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.575886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.81801779031291,"pubTatorScore":1.2619705132216792,"self":"https://pharos.nih.gov/idg/api/v1/targets(12498)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/publications"},"_namespace":null},{"id":12499,"version":2,"created":1554952604000,"modified":1554952610000,"deprecated":false,"name":"Hyaluronan and proteoglycan link protein 1","accession":"P10915","gene":"HAPLN1","description":"Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.182078483169025,"antibodyCount":162,"monoclonalCount":12,"pubmedCount":null,"jensenScore":145.56967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.673791835143064,"pubTatorScore":1.8732899617530543,"self":"https://pharos.nih.gov/idg/api/v1/targets(12499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/publications"},"_namespace":null},{"id":12500,"version":2,"created":1554952613000,"modified":1554952618000,"deprecated":false,"name":"Protein atonal homolog 1","accession":"Q92858","gene":"ATOH1","description":"Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3048345279247013,"antibodyCount":481,"monoclonalCount":183,"pubmedCount":null,"jensenScore":206.542829,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.05164202268514,"pubTatorScore":2.0620777596299544,"self":"https://pharos.nih.gov/idg/api/v1/targets(12500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/publications"},"_namespace":null},{"id":12501,"version":3,"created":1554952619000,"modified":1555040758000,"deprecated":false,"name":"Myosin regulatory light chain 2, ventricular/cardiac muscle isoform","accession":"P10916","gene":"MYL2","description":"Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). 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Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7177233304952353,"antibodyCount":135,"monoclonalCount":18,"pubmedCount":null,"jensenScore":5.277761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.1263543370302,"pubTatorScore":0.7047223617971146,"self":"https://pharos.nih.gov/idg/api/v1/targets(12522)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/publications"},"_namespace":null},{"id":12523,"version":2,"created":1554954619000,"modified":1554954621000,"deprecated":false,"name":"Noncompact myelin-associated protein","accession":"Q5T1S8","gene":"NCMAP","description":"Plays a role in myelin formation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.8519204791369825,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":73.783874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.41125759400234,"pubTatorScore":1.4078156423841977,"self":"https://pharos.nih.gov/idg/api/v1/targets(12523)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/properties"},"_links":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/publications"},"_namespace":null},{"id":12524,"version":2,"created":1554954622000,"modified":1554954622000,"deprecated":false,"name":"Olfactory receptor 4A8","accession":"P0C604","gene":"OR4A8","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.322283686764133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12524)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/publications"},"_namespace":null},{"id":12525,"version":2,"created":1554954622000,"modified":1554954622000,"deprecated":false,"name":"Testis-specific XK-related protein, Y-linked 2","accession":"A2RUG3","gene":"XKRY","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.22027915590490169,"self":"https://pharos.nih.gov/idg/api/v1/targets(12525)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/publications"},"_namespace":null},{"id":12526,"version":3,"created":1554954622000,"modified":1555040774000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX17","accession":"Q92841","gene":"DDX17","description":"As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1633322565657727,"antibodyCount":159,"monoclonalCount":16,"pubmedCount":null,"jensenScore":141.141988,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":48.57620200696543,"pubTatorScore":2.0146823316129985,"self":"https://pharos.nih.gov/idg/api/v1/targets(12526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/publications"},"_namespace":null},{"id":12527,"version":3,"created":1554954628000,"modified":1555040776000,"deprecated":false,"name":"Kinesin-associated protein 3","accession":"Q92845","gene":"KIFAP3","description":"Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3600735622420874,"antibodyCount":87,"monoclonalCount":16,"pubmedCount":null,"jensenScore":24.127086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":43.057893020228406,"pubTatorScore":1.3896415802766462,"self":"https://pharos.nih.gov/idg/api/v1/targets(12527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/publications"},"_namespace":null},{"id":12528,"version":2,"created":1554954633000,"modified":1554954637000,"deprecated":false,"name":"TRAF family member-associated NF-kappa-B activator","accession":"Q92844","gene":"TANK","description":"Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8199157204208893,"antibodyCount":373,"monoclonalCount":2,"pubmedCount":null,"jensenScore":67.507065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.89863909118823,"pubTatorScore":3.197120528491764,"self":"https://pharos.nih.gov/idg/api/v1/targets(12528)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/publications"},"_namespace":null},{"id":12529,"version":2,"created":1554954638000,"modified":1554954639000,"deprecated":false,"name":"Placenta-expressed transcript 1 protein","accession":"Q6UQ28","gene":"PLET1","description":"Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9586280035444114,"antibodyCount":52,"monoclonalCount":20,"pubmedCount":null,"jensenScore":9.74545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.33157074021415,"pubTatorScore":0.3881800924202411,"self":"https://pharos.nih.gov/idg/api/v1/targets(12529)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/properties"},"_links":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/publications"},"_namespace":null},{"id":12530,"version":3,"created":1554954640000,"modified":1555040778000,"deprecated":false,"name":"Bcl-2-like protein 2","accession":"Q92843","gene":"BCL2L2","description":"Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.088805091495287,"antibodyCount":298,"monoclonalCount":33,"pubmedCount":null,"jensenScore":100.218886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.2015888873417,"pubTatorScore":2.032734683472833,"self":"https://pharos.nih.gov/idg/api/v1/targets(12530)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":481,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/properties"},"_links":{"count":1835,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/synonyms"},"_publications":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/publications"},"_namespace":null},{"id":12531,"version":3,"created":1554954648000,"modified":1555040781000,"deprecated":false,"name":"Ectodysplasin-A","accession":"Q92838","gene":"EDA","description":"Isoform 3: Binds only to the receptor EDA2R.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1947234833103906,"antibodyCount":332,"monoclonalCount":72,"pubmedCount":null,"jensenScore":1441.098712,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":38.18174987056775,"pubTatorScore":3.0653471761045203,"self":"https://pharos.nih.gov/idg/api/v1/targets(12531)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/publications"},"_namespace":null},{"id":12532,"version":3,"created":1554954655000,"modified":1555040784000,"deprecated":false,"name":"Proto-oncogene FRAT1","accession":"Q92837","gene":"FRAT1","description":"Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3272622603379274,"antibodyCount":87,"monoclonalCount":5,"pubmedCount":null,"jensenScore":23.029893,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.52364960873802,"pubTatorScore":1.377220677152157,"self":"https://pharos.nih.gov/idg/api/v1/targets(12532)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/publications"},"_namespace":null},{"id":12533,"version":2,"created":1554954658000,"modified":1554954662000,"deprecated":false,"name":"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1","accession":"Q92835","gene":"INPP5D","description":"Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0694533740086722,"antibodyCount":374,"monoclonalCount":106,"pubmedCount":null,"jensenScore":104.731708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.042394029588145,"pubTatorScore":3.2036326469835386,"self":"https://pharos.nih.gov/idg/api/v1/targets(12533)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":484,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/publications"},"_namespace":null},{"id":12534,"version":3,"created":1554954663000,"modified":1555040785000,"deprecated":false,"name":"Methyltransferase-like protein 8","accession":"Q9H825","gene":"METTL8","description":"Probable methyltransferase.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.426357,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.26147191674264,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12534)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/publications"},"_namespace":null},{"id":12535,"version":2,"created":1554954666000,"modified":1554954669000,"deprecated":false,"name":"Hyaluronan synthase 1","accession":"Q92839","gene":"HAS1","description":"Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. 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Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.158947272278501,"antibodyCount":126,"monoclonalCount":23,"pubmedCount":null,"jensenScore":1400.640487,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.014297000807037,"pubTatorScore":2.2062031019114747,"self":"https://pharos.nih.gov/idg/api/v1/targets(12535)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/publications"},"_namespace":null},{"id":12536,"version":2,"created":1554954670000,"modified":1554954671000,"deprecated":false,"name":"Lipase member M","accession":"Q5VYY2","gene":"LIPM","description":"Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9904868541211794,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.638228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.268279069606658,"pubTatorScore":0.535715927820995,"self":"https://pharos.nih.gov/idg/api/v1/targets(12536)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/properties"},"_links":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/publications"},"_namespace":null},{"id":12537,"version":2,"created":1554954672000,"modified":1554954674000,"deprecated":false,"name":"Trafficking protein particle complex subunit 3-like protein","accession":"Q5T215","gene":"TRAPPC3L","description":"May play a role in vesicular transport from endoplasmic reticulum to Golgi.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.117647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.928225681294858,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(12537)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/properties"},"_links":{"count":690,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/publications"},"_namespace":null},{"id":12538,"version":2,"created":1554954675000,"modified":1554954675000,"deprecated":false,"name":"Proline-rich protein 31","accession":"Q5SQ13","gene":"PRR31","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.228461329915586,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12538)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/properties"},"_links":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/publications"},"_namespace":null},{"id":12539,"version":2,"created":1554954675000,"modified":1554954679000,"deprecated":false,"name":"Histone acetyltransferase KAT2A","accession":"Q92830","gene":"KAT2A","description":"Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. 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Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.46486544601553,"antibodyCount":262,"monoclonalCount":70,"pubmedCount":null,"jensenScore":271.896971,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.82502073150457,"pubTatorScore":2.167286732158134,"self":"https://pharos.nih.gov/idg/api/v1/targets(12539)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/publications"},"_namespace":null},{"id":12540,"version":3,"created":1554954680000,"modified":1555040786000,"deprecated":false,"name":"TATA box-binding protein-associated factor RNA polymerase I subunit B","accession":"Q53T94","gene":"TAF1B","description":"Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8807700833647377,"antibodyCount":66,"monoclonalCount":21,"pubmedCount":null,"jensenScore":6.781295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.642579886643105,"pubTatorScore":1.1156248548030947,"self":"https://pharos.nih.gov/idg/api/v1/targets(12540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/publications"},"_namespace":null},{"id":12541,"version":3,"created":1554954683000,"modified":1555040787000,"deprecated":false,"name":"X-linked retinitis pigmentosa GTPase regulator","accession":"Q92834","gene":"RPGR","description":"Could be a guanine-nucleotide releasing factor. 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May be involved in microtubule organization and regulation of transport in primary cilia.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.403270986846508,"antibodyCount":128,"monoclonalCount":1,"pubmedCount":null,"jensenScore":259.08834,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":40.740495680079945,"pubTatorScore":2.448172774499201,"self":"https://pharos.nih.gov/idg/api/v1/targets(12541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/properties"},"_links":{"count":1170,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/synonyms"},"_publications":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/publications"},"_namespace":null},{"id":12542,"version":2,"created":1554954690000,"modified":1554954693000,"deprecated":false,"name":"Pleckstrin homology domain-containing family G member 2","accession":"Q9H7P9","gene":"PLEKHG2","description":"May be a transforming oncogene with exchange activity for CDC42 (By similarity). 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Involved in the regulation of actin polymerization (PubMed:26573021).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.502778753326142,"antibodyCount":36,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.97373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.26047228374131,"pubTatorScore":1.2609186760189277,"self":"https://pharos.nih.gov/idg/api/v1/targets(12542)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/publications"},"_namespace":null},{"id":12543,"version":2,"created":1554954694000,"modified":1554954698000,"deprecated":false,"name":"Protein Jumonji","accession":"Q92833","gene":"JARID2","description":"Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-1.8013618794845636,"antibodyCount":135,"monoclonalCount":3,"pubmedCount":null,"jensenScore":65.274338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.07601660974156,"pubTatorScore":1.6006961107626145,"self":"https://pharos.nih.gov/idg/api/v1/targets(12543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/publications"},"_namespace":null},{"id":12544,"version":2,"created":1554954699000,"modified":1554954702000,"deprecated":false,"name":"DnaJ homolog subfamily C member 18","accession":"Q9H819","gene":"DNAJC18","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.749510638042846,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/publications"},"_namespace":null},{"id":12545,"version":3,"created":1554954703000,"modified":1555040789000,"deprecated":false,"name":"Protein kinase C-binding protein NELL1","accession":"Q92832","gene":"NELL1","description":"Plays a role in the control of cell growth and differentiation. 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Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.6284666757210173,"antibodyCount":331,"monoclonalCount":138,"pubmedCount":null,"jensenScore":372.001389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":51.18190002601317,"pubTatorScore":2.5911611121273848,"self":"https://pharos.nih.gov/idg/api/v1/targets(12546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":687,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/properties"},"_links":{"count":1232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/links"},"_synonyms":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/synonyms"},"_publications":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/publications"},"_namespace":null},{"id":12547,"version":3,"created":1554954716000,"modified":1555040793000,"deprecated":false,"name":"Multivesicular body subunit 12B","accession":"Q9H7P6","gene":"MVB12B","description":"Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0666807933532423,"antibodyCount":19,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.654701,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.06373750108149,"pubTatorScore":0.6460300526505441,"self":"https://pharos.nih.gov/idg/api/v1/targets(12547)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/publications"},"_namespace":null},{"id":12548,"version":3,"created":1554954719000,"modified":1555040794000,"deprecated":false,"name":"5' exonuclease Apollo","accession":"Q9H816","gene":"DCLRE1B","description":"5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1523148336799225,"antibodyCount":78,"monoclonalCount":8,"pubmedCount":null,"jensenScore":16.040707,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.00039829965596,"pubTatorScore":1.5049991433708312,"self":"https://pharos.nih.gov/idg/api/v1/targets(12548)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/publications"},"_namespace":null},{"id":12549,"version":3,"created":1554954724000,"modified":1555040795000,"deprecated":false,"name":"Interferon-induced protein with tetratricopeptide repeats 2","accession":"P09913","gene":"IFIT2","description":"IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. 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Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). 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May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.0544294513429056,"antibodyCount":46,"monoclonalCount":1,"pubmedCount":null,"jensenScore":10.833079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.768545960229872,"pubTatorScore":1.0014452264457927,"self":"https://pharos.nih.gov/idg/api/v1/targets(12922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/publications"},"_namespace":null},{"id":12923,"version":2,"created":1554958931000,"modified":1554958933000,"deprecated":false,"name":"LHFPL tetraspan subfamily member 5 protein","accession":"Q8TAF8","gene":"LHFPL5","description":"In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. 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This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.722780565105562,"antibodyCount":1453,"monoclonalCount":315,"pubmedCount":null,"jensenScore":4886.48665,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.83668138356356,"pubTatorScore":3.614837965053387,"self":"https://pharos.nih.gov/idg/api/v1/targets(12962)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1367,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/properties"},"_links":{"count":3579,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/links"},"_synonyms":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/synonyms"},"_publications":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/publications"},"_namespace":null},{"id":12963,"version":3,"created":1554959747000,"modified":1554959777000,"deprecated":false,"name":"Dipeptidyl peptidase 8","accession":"Q6V1X1","gene":"DPP8","description":"Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. 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Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.598134392800389,"antibodyCount":1290,"monoclonalCount":938,"pubmedCount":null,"jensenScore":3485.900809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":38.294197012333974,"pubTatorScore":3.349246576810923,"self":"https://pharos.nih.gov/idg/api/v1/targets(12970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/properties"},"_links":{"count":1210,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/publications"},"_namespace":null},{"id":12971,"version":2,"created":1554959807000,"modified":1554959809000,"deprecated":false,"name":"Zinc finger protein 696","accession":"Q9H7X3","gene":"ZNF696","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.071429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.78163227440952,"pubTatorScore":-1.041393119452924,"self":"https://pharos.nih.gov/idg/api/v1/targets(12971)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/properties"},"_links":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/publications"},"_namespace":null},{"id":12972,"version":2,"created":1554959810000,"modified":1554959812000,"deprecated":false,"name":"Lipase member I","accession":"Q6XZB0","gene":"LIPI","description":"Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7988638038782332,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":59.881929,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.955122028368866,"pubTatorScore":1.0236155097608528,"self":"https://pharos.nih.gov/idg/api/v1/targets(12972)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/properties"},"_links":{"count":705,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/publications"},"_namespace":null},{"id":12973,"version":2,"created":1554959813000,"modified":1554959816000,"deprecated":false,"name":"N-alpha-acetyltransferase 60","accession":"Q9H7X0","gene":"NAA60","description":"N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.422627590107911,"antibodyCount":89,"monoclonalCount":3,"pubmedCount":null,"jensenScore":24.460451,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.796996159722195,"pubTatorScore":0.8101204340434858,"self":"https://pharos.nih.gov/idg/api/v1/targets(12973)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/publications"},"_namespace":null},{"id":12974,"version":3,"created":1554959816000,"modified":1554959856000,"deprecated":false,"name":"Protein kinase C delta type","accession":"Q05655","gene":"PRKCD","description":"Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.1845245287794928,"antibodyCount":804,"monoclonalCount":140,"pubmedCount":null,"jensenScore":141.432359,"patentCount":7423,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":58.511156890794105,"pubTatorScore":3.2951110931035186,"self":"https://pharos.nih.gov/idg/api/v1/targets(12974)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1180,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/properties"},"_links":{"count":1730,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/synonyms"},"_publications":{"count":579,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/publications"},"_namespace":null},{"id":12975,"version":2,"created":1554959859000,"modified":1554959860000,"deprecated":false,"name":"Testis-expressed protein 49","accession":"A0A1B0GTD5","gene":"TEX49","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12975)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/properties"},"_links":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/publications"},"_namespace":null},{"id":12976,"version":3,"created":1554959860000,"modified":1555041066000,"deprecated":false,"name":"Rieske domain-containing protein","accession":"Q8TAC1","gene":"RFESD","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":122,"monoclonalCount":15,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":23.40072982742963,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12976)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/publications"},"_namespace":null},{"id":12977,"version":3,"created":1554959862000,"modified":1555041067000,"deprecated":false,"name":"Josephin-2","accession":"Q8TAC2","gene":"JOSD2","description":"Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). 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Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6514413338693852,"antibodyCount":106,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.999436,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.24952190569653,"pubTatorScore":0.7619100304789258,"self":"https://pharos.nih.gov/idg/api/v1/targets(13049)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(13049)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(13049)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(13049)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(13049)/publications"},"_namespace":null},{"id":13050,"version":2,"created":1554961616000,"modified":1554961619000,"deprecated":false,"name":"Rho-related GTP-binding protein Rho6","accession":"Q92730","gene":"RND1","description":"Lacks intrinsic GTPase activity. 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Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.269512951166628,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":19.136544,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.05476277356513,"pubTatorScore":1.1167183952967812,"self":"https://pharos.nih.gov/idg/api/v1/targets(13167)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(13167)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(13167)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(13167)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(13167)/publications"},"_namespace":null},{"id":13168,"version":2,"created":1554962668000,"modified":1554962672000,"deprecated":false,"name":"Nuclear receptor ROR-beta","accession":"Q92753","gene":"RORB","description":"Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. 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Plays a role in spermiogenesis and oogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.6020599913279624,"antibodyCount":80,"monoclonalCount":11,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.09765529462975,"pubTatorScore":1.1861765883977378,"self":"https://pharos.nih.gov/idg/api/v1/targets(13171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/publications"},"_namespace":null},{"id":13172,"version":3,"created":1554962726000,"modified":1555041192000,"deprecated":false,"name":"Coiled-coil domain-containing protein 40","accession":"Q4G0X9","gene":"CCDC40","description":"Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8982644020246348,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.802858,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":33.47720066590593,"pubTatorScore":0.8050808371163336,"self":"https://pharos.nih.gov/idg/api/v1/targets(13172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/publications"},"_namespace":null},{"id":13173,"version":3,"created":1554962731000,"modified":1555041194000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 10B","accession":"O14763","gene":"TNFRSF10B","description":"Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.159630396365398,"antibodyCount":849,"monoclonalCount":363,"pubmedCount":null,"jensenScore":1514.75245,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":45.39718496135189,"pubTatorScore":2.905058746735743,"self":"https://pharos.nih.gov/idg/api/v1/targets(13173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(13173)/properties"},"_links":{"count":1346,"href":"https://pharos.nih.gov/idg/api/v1/targets(13173)/links"},"_synonyms":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(13173)/synonyms"},"_publications":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(13173)/publications"},"_namespace":null},{"id":13174,"version":3,"created":1554962738000,"modified":1555041197000,"deprecated":false,"name":"Ribose-phosphate pyrophosphokinase 2","accession":"P11908","gene":"PRPS2","description":"Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.7014381512834793,"antibodyCount":176,"monoclonalCount":26,"pubmedCount":null,"jensenScore":49.239225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":37.05058382600868,"pubTatorScore":1.215810480241836,"self":"https://pharos.nih.gov/idg/api/v1/targets(13174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(13174)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(13174)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(13174)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(13174)/publications"},"_namespace":null},{"id":13175,"version":3,"created":1554962743000,"modified":1555041198000,"deprecated":false,"name":"Baculoviral IAP repeat-containing protein 7","accession":"Q96CA5","gene":"BIRC7","description":"Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.276792332474795,"antibodyCount":462,"monoclonalCount":101,"pubmedCount":null,"jensenScore":206.767688,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":23.24452265720109,"pubTatorScore":2.303962795826056,"self":"https://pharos.nih.gov/idg/api/v1/targets(13175)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(13175)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(13175)/links"},"_synonyms":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(13175)/synonyms"},"_publications":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(13175)/publications"},"_namespace":null},{"id":13176,"version":2,"created":1554962747000,"modified":1554962750000,"deprecated":false,"name":"BTB/POZ domain-containing protein KCTD21","accession":"Q4G0X4","gene":"KCTD21","description":"Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. 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Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.6020599913279624,"antibodyCount":84,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.273809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.817906289236657,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(13176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(13176)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(13176)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(13176)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(13176)/publications"},"_namespace":null},{"id":13177,"version":2,"created":1554962751000,"modified":1554962755000,"deprecated":false,"name":"Transcription factor AP-2 gamma","accession":"Q92754","gene":"TFAP2C","description":"Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8840638064127406,"antibodyCount":269,"monoclonalCount":60,"pubmedCount":null,"jensenScore":72.742422,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.30680688782163,"pubTatorScore":1.739073774680865,"self":"https://pharos.nih.gov/idg/api/v1/targets(13177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/publications"},"_namespace":null},{"id":13178,"version":3,"created":1554962756000,"modified":1555041200000,"deprecated":false,"name":"Kinesin-like protein KIF2A","accession":"O00139","gene":"KIF2A","description":"Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6078120144738461,"antibodyCount":145,"monoclonalCount":40,"pubmedCount":null,"jensenScore":42.726739,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.15993993113931,"pubTatorScore":1.8398574336240132,"self":"https://pharos.nih.gov/idg/api/v1/targets(13178)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(13178)/properties"},"_links":{"count":1208,"href":"https://pharos.nih.gov/idg/api/v1/targets(13178)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(13178)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(13178)/publications"},"_namespace":null},{"id":13179,"version":3,"created":1554962762000,"modified":1555041202000,"deprecated":false,"name":"Thyroid hormone-inducible hepatic protein","accession":"Q92748","gene":"THRSP","description":"Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3782246389870854,"antibodyCount":105,"monoclonalCount":10,"pubmedCount":null,"jensenScore":221.459116,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":37,"knowledgeAvailability":23.532118517354526,"pubTatorScore":1.5402996488747827,"self":"https://pharos.nih.gov/idg/api/v1/targets(13179)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/publications"},"_namespace":null},{"id":13180,"version":3,"created":1554962766000,"modified":1555041203000,"deprecated":false,"name":"Actin-related 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May also promote ubiquitination and endocytosis of TFRC and FAS.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6814026859540838,"antibodyCount":119,"monoclonalCount":9,"pubmedCount":null,"jensenScore":46.877039,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.011074305715695,"pubTatorScore":0.9350591370289841,"self":"https://pharos.nih.gov/idg/api/v1/targets(13192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/publications"},"_namespace":null},{"id":13193,"version":3,"created":1554962819000,"modified":1555041216000,"deprecated":false,"name":"Serine/threonine-protein kinase Sgk1","accession":"O00141","gene":"SGK1","description":"Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.679789301780927,"antibodyCount":642,"monoclonalCount":108,"pubmedCount":null,"jensenScore":543.652742,"patentCount":31010,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":58.65547563268133,"pubTatorScore":2.4635908582220396,"self":"https://pharos.nih.gov/idg/api/v1/targets(13193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":678,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/properties"},"_links":{"count":1459,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/synonyms"},"_publications":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/publications"},"_namespace":null},{"id":13194,"version":3,"created":1554962844000,"modified":1555041219000,"deprecated":false,"name":"Tripeptidyl-peptidase 1","accession":"O14773","gene":"TPP1","description":"Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1832345478331034,"antibodyCount":273,"monoclonalCount":56,"pubmedCount":null,"jensenScore":155.212345,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":44.98095208915767,"pubTatorScore":2.3768826985626097,"self":"https://pharos.nih.gov/idg/api/v1/targets(13194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/properties"},"_links":{"count":1205,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/synonyms"},"_publications":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/publications"},"_namespace":null},{"id":13195,"version":2,"created":1554962850000,"modified":1554962853000,"deprecated":false,"name":"Fucose-1-phosphate guanylyltransferase","accession":"O14772","gene":"FPGT","description":"Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. 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Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9249631779295664,"antibodyCount":222,"monoclonalCount":20,"pubmedCount":null,"jensenScore":86.862606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.36605946914393,"pubTatorScore":1.6488399680161807,"self":"https://pharos.nih.gov/idg/api/v1/targets(13197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/publications"},"_namespace":null},{"id":13198,"version":3,"created":1554962861000,"modified":1555041222000,"deprecated":false,"name":"Kinetochore protein NDC80 homolog","accession":"O14777","gene":"NDC80","description":"Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4512360338992587,"antibodyCount":300,"monoclonalCount":62,"pubmedCount":null,"jensenScore":265.15585,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.21204605240898,"pubTatorScore":2.3053244681552685,"self":"https://pharos.nih.gov/idg/api/v1/targets(13198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/publications"},"_namespace":null},{"id":13199,"version":3,"created":1554962867000,"modified":1555041224000,"deprecated":false,"name":"Heme oxygenase 1","accession":"P09601","gene":"HMOX1","description":"Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.7500438180413194,"antibodyCount":706,"monoclonalCount":188,"pubmedCount":null,"jensenScore":6181.327546,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":51.834309210844246,"pubTatorScore":3.421584454083458,"self":"https://pharos.nih.gov/idg/api/v1/targets(13199)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1320,"href":"https://pharos.nih.gov/idg/api/v1/targets(13199)/properties"},"_links":{"count":1983,"href":"https://pharos.nih.gov/idg/api/v1/targets(13199)/links"},"_synonyms":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(13199)/synonyms"},"_publications":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(13199)/publications"},"_namespace":null},{"id":13200,"version":2,"created":1554962881000,"modified":1554962885000,"deprecated":false,"name":"Transcription elongation regulator 1","accession":"O14776","gene":"TCERG1","description":"Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.311252800662292,"antibodyCount":140,"monoclonalCount":14,"pubmedCount":null,"jensenScore":194.897795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.16914618468104,"pubTatorScore":1.6178362349162032,"self":"https://pharos.nih.gov/idg/api/v1/targets(13200)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(13200)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(13200)/links"},"_synonyms":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(13200)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(13200)/publications"},"_namespace":null},{"id":13201,"version":2,"created":1554962887000,"modified":1554962887000,"deprecated":false,"name":"Double homeobox protein 4C","accession":"Q6RFH8","gene":"DUX4L9","description":"May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. 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May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.39731914013806996,"antibodyCount":59,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.687645,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.85402033579902,"pubTatorScore":0.14754926292833342,"self":"https://pharos.nih.gov/idg/api/v1/targets(13218)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/publications"},"_namespace":null},{"id":13219,"version":2,"created":1554962955000,"modified":1554962957000,"deprecated":false,"name":"RANBP2-like and GRIP domain-containing protein 8","accession":"O14715","gene":"RGPD8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4966661244925651,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.496743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.894047261852315,"pubTatorScore":0.10833936198506207,"self":"https://pharos.nih.gov/idg/api/v1/targets(13219)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/publications"},"_namespace":null},{"id":13220,"version":2,"created":1554962958000,"modified":1554962961000,"deprecated":false,"name":"tRNA (cytosine(38)-C(5))-methyltransferase","accession":"O14717","gene":"TRDMT1","description":"Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9962814667684947,"antibodyCount":337,"monoclonalCount":72,"pubmedCount":null,"jensenScore":94.902178,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.89706684980281,"pubTatorScore":1.6852204695177713,"self":"https://pharos.nih.gov/idg/api/v1/targets(13220)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/publications"},"_namespace":null},{"id":13221,"version":2,"created":1554962962000,"modified":1554962965000,"deprecated":false,"name":"Visual pigment-like receptor peropsin","accession":"O14718","gene":"RRH","description":"May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.6359982700450397,"antibodyCount":112,"monoclonalCount":0,"pubmedCount":null,"jensenScore":41.722642,"patentCount":2613,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.524441021305126,"pubTatorScore":1.312243151725746,"self":"https://pharos.nih.gov/idg/api/v1/targets(13221)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/publications"},"_namespace":null},{"id":13222,"version":2,"created":1554962965000,"modified":1554962969000,"deprecated":false,"name":"tRNA-splicing endonuclease subunit Sen54","accession":"Q7Z6J9","gene":"TSEN54","description":"Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. 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The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.40388276242245,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":27.202778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.371394417411302,"pubTatorScore":1.4585119382462493,"self":"https://pharos.nih.gov/idg/api/v1/targets(13222)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(13222)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(13222)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(13222)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(13222)/publications"},"_namespace":null},{"id":13223,"version":3,"created":1554962970000,"modified":1555041231000,"deprecated":false,"name":"E3 ubiquitin-protein ligase E3D","accession":"Q7Z6J8","gene":"UBE3D","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.2658655823646157,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.590909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":24.55770351663281,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(13223)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(13223)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(13223)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13223)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(13223)/publications"},"_namespace":null},{"id":13224,"version":2,"created":1554962974000,"modified":1554962977000,"deprecated":false,"name":"Integrin beta-1-binding protein 1","accession":"O14713","gene":"ITGB1BP1","description":"Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. 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Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2312794128302602,"antibodyCount":138,"monoclonalCount":56,"pubmedCount":null,"jensenScore":20.778149,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.86089307267551,"pubTatorScore":1.2273152444098903,"self":"https://pharos.nih.gov/idg/api/v1/targets(13224)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/publications"},"_namespace":null},{"id":13225,"version":3,"created":1554962978000,"modified":1555041232000,"deprecated":false,"name":"Zinc finger protein 524","accession":"Q96C55","gene":"ZNF524","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":61,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":25.369280776693078,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13225)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/publications"},"_namespace":null},{"id":13226,"version":2,"created":1554962981000,"modified":1554962982000,"deprecated":false,"name":"Uncharacterized protein C12orf43","accession":"Q96C57","gene":"C12orf43","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13226)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/publications"},"_namespace":null},{"id":13227,"version":2,"created":1554962983000,"modified":1554962987000,"deprecated":false,"name":"Alkylated DNA repair protein alkB homolog 8","accession":"Q96BT7","gene":"ALKBH8","description":"Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). 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May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2683346155886008,"antibodyCount":107,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.038417,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.641947741624485,"pubTatorScore":1.0414866405276861,"self":"https://pharos.nih.gov/idg/api/v1/targets(13227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/publications"},"_namespace":null},{"id":13228,"version":2,"created":1554962987000,"modified":1554962989000,"deprecated":false,"name":"Putative uncharacterized protein C3orf49","accession":"Q96BT1","gene":"C3orf49","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/properties"},"_links":{"count":675,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/publications"},"_namespace":null},{"id":13229,"version":2,"created":1554962989000,"modified":1554962993000,"deprecated":false,"name":"Rho GTPase-activating protein 30","accession":"Q7Z6I6","gene":"ARHGAP30","description":"GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.047923551376211425,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.236842,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.970813401435155,"pubTatorScore":0.1879905762568884,"self":"https://pharos.nih.gov/idg/api/v1/targets(13229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/publications"},"_namespace":null},{"id":13230,"version":2,"created":1554962994000,"modified":1554962997000,"deprecated":false,"name":"Centromere protein T","accession":"Q96BT3","gene":"CENPT","description":"Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. 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Required for normal chromosome organization and normal progress through mitosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1951086010235834,"antibodyCount":69,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.432522,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.38148209845784,"pubTatorScore":1.1161252365208771,"self":"https://pharos.nih.gov/idg/api/v1/targets(13230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/properties"},"_links":{"count":962,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/publications"},"_namespace":null},{"id":13231,"version":2,"created":1554962998000,"modified":1554962999000,"deprecated":false,"name":"Putative ubiquitin carboxyl-terminal hydrolase 41","accession":"Q3LFD5","gene":"USP41","description":"May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. 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Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3856700561636346,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":23.949457,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6823527837864158,"self":"https://pharos.nih.gov/idg/api/v1/targets(13586)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/publications"},"_namespace":null},{"id":13587,"version":3,"created":1554966094000,"modified":1555041468000,"deprecated":false,"name":"Zinc finger protein 576","accession":"Q9H609","gene":"ZNF576","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":19,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":27.55888093391931,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13587)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/properties"},"_links":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/publications"},"_namespace":null},{"id":13588,"version":3,"created":1554966096000,"modified":1555041471000,"deprecated":false,"name":"La-related protein 4B","accession":"Q92615","gene":"LARP4B","description":"Stimulates mRNA translation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7140102545432284,"antibodyCount":24,"monoclonalCount":1,"pubmedCount":null,"jensenScore":5.115618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":69,"knowledgeAvailability":35.76022967470825,"pubTatorScore":0.5593080109070125,"self":"https://pharos.nih.gov/idg/api/v1/targets(13588)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/publications"},"_namespace":null},{"id":13589,"version":3,"created":1554966101000,"modified":1555041472000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit G","accession":"O75821","gene":"EIF3G","description":"(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0866576659656382,"antibodyCount":190,"monoclonalCount":9,"pubmedCount":null,"jensenScore":12.468238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":39.69820679497177,"pubTatorScore":0.951109964665797,"self":"https://pharos.nih.gov/idg/api/v1/targets(13589)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/publications"},"_namespace":null},{"id":13590,"version":2,"created":1554966106000,"modified":1554966109000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit J","accession":"O75822","gene":"EIF3J","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0212071988858826,"antibodyCount":106,"monoclonalCount":4,"pubmedCount":null,"jensenScore":10.319215,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.13407647402364,"pubTatorScore":1.3786141766189737,"self":"https://pharos.nih.gov/idg/api/v1/targets(13590)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/publications"},"_namespace":null},{"id":13591,"version":2,"created":1554966110000,"modified":1554966113000,"deprecated":false,"name":"Zinc finger protein 189","accession":"O75820","gene":"ZNF189","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.4771212590626073,"antibodyCount":43,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.904761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.89445489363687,"pubTatorScore":0.691670706707128,"self":"https://pharos.nih.gov/idg/api/v1/targets(13591)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/publications"},"_namespace":null},{"id":13592,"version":2,"created":1554966114000,"modified":1554966118000,"deprecated":false,"name":"Rho GTPase-activating protein 45","accession":"Q92619","gene":"ARHGAP45","description":"Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. 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Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9892139396180415,"antibodyCount":85,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.382588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.20463193811738,"pubTatorScore":0.5808705999704371,"self":"https://pharos.nih.gov/idg/api/v1/targets(13593)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/publications"},"_namespace":null},{"id":13594,"version":2,"created":1554966123000,"modified":1554966127000,"deprecated":false,"name":"Membrane-associated progesterone receptor component 1","accession":"O00264","gene":"PGRMC1","description":"Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1287423926384497,"antibodyCount":133,"monoclonalCount":9,"pubmedCount":null,"jensenScore":1353.673283,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.14774107421195,"pubTatorScore":2.1001640786377482,"self":"https://pharos.nih.gov/idg/api/v1/targets(13594)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/publications"},"_namespace":null},{"id":13595,"version":2,"created":1554966129000,"modified":1554966133000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 4","accession":"O00268","gene":"TAF4","description":"Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. 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Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266). May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865). May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.176207665576002,"antibodyCount":60,"monoclonalCount":15,"pubmedCount":null,"jensenScore":148.917557,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.95518346490242,"pubTatorScore":1.1419720550275374,"self":"https://pharos.nih.gov/idg/api/v1/targets(13596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/publications"},"_namespace":null},{"id":13597,"version":2,"created":1554966138000,"modified":1554966142000,"deprecated":false,"name":"Transcription elongation factor SPT5","accession":"O00267","gene":"SUPT5H","description":"Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. 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Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. 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May play a role in the cellular response to oxidative stress (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8784944542235943,"antibodyCount":52,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.652381,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.44865554743532,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(13693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/publications"},"_namespace":null},{"id":13694,"version":2,"created":1554966756000,"modified":1554966760000,"deprecated":false,"name":"IQ motif and SEC7 domain-containing protein 2","accession":"Q5JU85","gene":"IQSEC2","description":"Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4244414304798556,"antibodyCount":50,"monoclonalCount":2,"pubmedCount":null,"jensenScore":29.77378,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.76474842785711,"pubTatorScore":1.2385905878628563,"self":"https://pharos.nih.gov/idg/api/v1/targets(13694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/publications"},"_namespace":null},{"id":13695,"version":2,"created":1554966761000,"modified":1554966765000,"deprecated":false,"name":"Copper transport protein ATOX1","accession":"O00244","gene":"ATOX1","description":"Binds and deliver cytosolic copper to the copper ATPase proteins. 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May play a role in cilium biogenesis (PubMed:27588451).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4648868019217715,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.865705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.40799279412868,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(13697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/publications"},"_namespace":null},{"id":13698,"version":2,"created":1554966774000,"modified":1554966778000,"deprecated":false,"name":"Lysophospholipase-like protein 1","accession":"Q5VWZ2","gene":"LYPLAL1","description":"Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1862303244562467,"antibodyCount":127,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.351079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.003641885843464,"pubTatorScore":1.1019388221005013,"self":"https://pharos.nih.gov/idg/api/v1/targets(13698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/publications"},"_namespace":null},{"id":13699,"version":3,"created":1554966779000,"modified":1555041527000,"deprecated":false,"name":"Dual specificity tyrosine-phosphorylation-regulated kinase 2","accession":"Q92630","gene":"DYRK2","description":"Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.5860176391489063,"antibodyCount":247,"monoclonalCount":44,"pubmedCount":null,"jensenScore":36.489192,"patentCount":3632,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.26853654320587,"pubTatorScore":1.4458328403742196,"self":"https://pharos.nih.gov/idg/api/v1/targets(13699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/publications"},"_namespace":null},{"id":13700,"version":3,"created":1554966784000,"modified":1555041529000,"deprecated":false,"name":"Protein FAN","accession":"Q92636","gene":"NSMAF","description":"Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9938575099681232,"antibodyCount":96,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.296653,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":41.03652404097106,"pubTatorScore":1.6980141916368547,"self":"https://pharos.nih.gov/idg/api/v1/targets(13700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/publications"},"_namespace":null},{"id":13701,"version":3,"created":1554966789000,"modified":1555041533000,"deprecated":false,"name":"Lysophosphatidic acid receptor 1","accession":"Q92633","gene":"LPAR1","description":"Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.3490546200672964,"antibodyCount":237,"monoclonalCount":20,"pubmedCount":null,"jensenScore":222.69017,"patentCount":23418,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":96,"knowledgeAvailability":39.71139627157746,"pubTatorScore":2.185615525442873,"self":"https://pharos.nih.gov/idg/api/v1/targets(13701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/publications"},"_namespace":null},{"id":13702,"version":3,"created":1554966803000,"modified":1555041534000,"deprecated":false,"name":"Delta-sarcoglycan","accession":"Q92629","gene":"SGCD","description":"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1719216998759596,"antibodyCount":178,"monoclonalCount":38,"pubmedCount":null,"jensenScore":140.760579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.3395771198736,"pubTatorScore":1.6326058987284278,"self":"https://pharos.nih.gov/idg/api/v1/targets(13702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/publications"},"_namespace":null},{"id":13703,"version":2,"created":1554966808000,"modified":1554966812000,"deprecated":false,"name":"Uncharacterized protein KIAA0232","accession":"Q92628","gene":"KIAA0232","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.4,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.00790886397356,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(13703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/publications"},"_namespace":null},{"id":13704,"version":2,"created":1554966812000,"modified":1554966817000,"deprecated":false,"name":"Protein CLEC16A","accession":"Q2KHT3","gene":"CLEC16A","description":"Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. 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Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6286158647681683,"antibodyCount":141,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.30746,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.14551117058072,"pubTatorScore":1.6706076978780262,"self":"https://pharos.nih.gov/idg/api/v1/targets(13704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/publications"},"_namespace":null},{"id":13705,"version":3,"created":1554966818000,"modified":1555041536000,"deprecated":false,"name":"Germ cell-specific gene 1 protein","accession":"Q2KHT4","gene":"GSG1","description":"May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":100,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":24.343499091034793,"pubTatorScore":-0.39280026683270164,"self":"https://pharos.nih.gov/idg/api/v1/targets(13705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/properties"},"_links":{"count":744,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/publications"},"_namespace":null},{"id":13706,"version":2,"created":1554966821000,"modified":1554966826000,"deprecated":false,"name":"Peroxidasin homolog","accession":"Q92626","gene":"PXDN","description":"Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. 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Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.2653879042642236,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/publications"},"_namespace":null},{"id":13747,"version":3,"created":1554967024000,"modified":1555041554000,"deprecated":false,"name":"Toll-like receptor 4","accession":"O00206","gene":"TLR4","description":"Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.8192721522554933,"antibodyCount":1289,"monoclonalCount":673,"pubmedCount":null,"jensenScore":6905.756474,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.82334934560312,"pubTatorScore":3.5475047371253403,"self":"https://pharos.nih.gov/idg/api/v1/targets(13747)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2557,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/properties"},"_links":{"count":3058,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/links"},"_synonyms":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/synonyms"},"_publications":{"count":2046,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/publications"},"_namespace":null},{"id":13748,"version":2,"created":1554967054000,"modified":1554967055000,"deprecated":false,"name":"PRAME family member 18","accession":"Q5VWM3","gene":"PRAMEF18","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13748)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/properties"},"_links":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/publications"},"_namespace":null},{"id":13749,"version":2,"created":1554967055000,"modified":1554967058000,"deprecated":false,"name":"Claudin-23","accession":"Q96B33","gene":"CLDN23","description":"Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6870876953751025,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.814132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.397912815200986,"pubTatorScore":0.6808328991341088,"self":"https://pharos.nih.gov/idg/api/v1/targets(13749)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/properties"},"_links":{"count":722,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/publications"},"_namespace":null},{"id":13750,"version":3,"created":1554967059000,"modified":1555041565000,"deprecated":false,"name":"Proline-rich AKT1 substrate 1","accession":"Q96B36","gene":"AKT1S1","description":"Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.257553754859258,"antibodyCount":434,"monoclonalCount":115,"pubmedCount":null,"jensenScore":174.159663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":39.85171520978411,"pubTatorScore":1.738778933839564,"self":"https://pharos.nih.gov/idg/api/v1/targets(13750)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/publications"},"_namespace":null},{"id":13751,"version":2,"created":1554967063000,"modified":1554967064000,"deprecated":false,"name":"Putative PRAME family member 13","accession":"Q5VWM6","gene":"PRAMEF13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.090909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(13751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/properties"},"_links":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/publications"},"_namespace":null},{"id":13752,"version":2,"created":1554967064000,"modified":1554967064000,"deprecated":false,"name":"PRAME family member 9/15","accession":"Q5VWM5","gene":"PRAMEF15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.983034951053189,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/publications"},"_namespace":null},{"id":13753,"version":3,"created":1554967064000,"modified":1555041566000,"deprecated":false,"name":"Golgin subfamily A member 7","accession":"Q7Z5G4","gene":"GOLGA7","description":"May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3960055135273124,"antibodyCount":93,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.535173,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.47771980860935,"pubTatorScore":0.22862027368254095,"self":"https://pharos.nih.gov/idg/api/v1/targets(13753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/publications"},"_namespace":null},{"id":13754,"version":2,"created":1554967068000,"modified":1554967068000,"deprecated":false,"name":"PRAME family member 8","accession":"Q5VWM4","gene":"PRAMEF8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.2913673288999785,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/properties"},"_links":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/publications"},"_namespace":null},{"id":13755,"version":2,"created":1554967068000,"modified":1554967071000,"deprecated":false,"name":"Sulfotransferase family cytosolic 2B member 1","accession":"O00204","gene":"SULT2B1","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.316073550430515,"antibodyCount":185,"monoclonalCount":25,"pubmedCount":null,"jensenScore":178.163797,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.38340316027375,"pubTatorScore":1.5054148171862225,"self":"https://pharos.nih.gov/idg/api/v1/targets(13755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/publications"},"_namespace":null},{"id":13756,"version":2,"created":1554967072000,"modified":1554967077000,"deprecated":false,"name":"AP-3 complex subunit beta-1","accession":"O00203","gene":"AP3B1","description":"Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2769919886474803,"antibodyCount":89,"monoclonalCount":23,"pubmedCount":null,"jensenScore":21.010365,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.45898360596348,"pubTatorScore":1.3663910143926175,"self":"https://pharos.nih.gov/idg/api/v1/targets(13756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/publications"},"_namespace":null},{"id":13757,"version":2,"created":1554967078000,"modified":1554967081000,"deprecated":false,"name":"5-oxoprolinase","accession":"O14841","gene":"OPLAH","description":"Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.746730939289634,"pubTatorScore":1.148934818547686,"self":"https://pharos.nih.gov/idg/api/v1/targets(13757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/properties"},"_links":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/publications"},"_namespace":null},{"id":13758,"version":2,"created":1554967081000,"modified":1554967084000,"deprecated":false,"name":"Free fatty acid receptor 3","accession":"O14843","gene":"FFAR3","description":"G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.7539546612120667,"antibodyCount":120,"monoclonalCount":3,"pubmedCount":null,"jensenScore":54.954687,"patentCount":4253,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.59721781107618,"pubTatorScore":1.5391811326373617,"self":"https://pharos.nih.gov/idg/api/v1/targets(13758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/publications"},"_namespace":null},{"id":13759,"version":3,"created":1554967084000,"modified":1554967167000,"deprecated":false,"name":"Free fatty acid receptor 1","accession":"O14842","gene":"FFAR1","description":"G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.438014224846319,"antibodyCount":231,"monoclonalCount":7,"pubmedCount":null,"jensenScore":296.216516,"patentCount":29866,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.196074619717667,"pubTatorScore":2.1892318863521654,"self":"https://pharos.nih.gov/idg/api/v1/targets(13759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/publications"},"_namespace":null},{"id":13760,"version":3,"created":1554967168000,"modified":1555041568000,"deprecated":false,"name":"Kelch-like protein 40","accession":"Q2TBA0","gene":"KLHL40","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1856702824169048,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.804843,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":16.84931712069857,"pubTatorScore":0.5186705208698187,"self":"https://pharos.nih.gov/idg/api/v1/targets(13760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/properties"},"_links":{"count":706,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/publications"},"_namespace":null},{"id":13761,"version":2,"created":1554967171000,"modified":1554967174000,"deprecated":false,"name":"Uncharacterized protein C18orf25","accession":"Q96B23","gene":"C18orf25","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.23044892441833534,"antibodyCount":90,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.49359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3635222916413859,"self":"https://pharos.nih.gov/idg/api/v1/targets(13761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/publications"},"_namespace":null},{"id":13762,"version":2,"created":1554967175000,"modified":1554967178000,"deprecated":false,"name":"Protein LSM12 homolog","accession":"Q3MHD2","gene":"LSM12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7819442428294234,"antibodyCount":74,"monoclonalCount":7,"pubmedCount":null,"jensenScore":5.885318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.17083156130934,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(13762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/publications"},"_namespace":null},{"id":13763,"version":2,"created":1554967179000,"modified":1554967187000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","accession":"O00217","gene":"NDUFS8","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. 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May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.817487200114034,"antibodyCount":215,"monoclonalCount":19,"pubmedCount":null,"jensenScore":78.50787,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.88460969292632,"pubTatorScore":1.6685745235601872,"self":"https://pharos.nih.gov/idg/api/v1/targets(13769)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/publications"},"_namespace":null},{"id":13770,"version":3,"created":1554967212000,"modified":1555041573000,"deprecated":false,"name":"Amyloid-beta A4 precursor protein-binding family B member 1","accession":"O00213","gene":"APBB1","description":"Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.289036881004724,"antibodyCount":285,"monoclonalCount":21,"pubmedCount":null,"jensenScore":200.761293,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":36.58553857152854,"pubTatorScore":2.0138727512978662,"self":"https://pharos.nih.gov/idg/api/v1/targets(13770)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/properties"},"_links":{"count":1298,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/links"},"_synonyms":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/publications"},"_namespace":null},{"id":13771,"version":3,"created":1554967218000,"modified":1555041576000,"deprecated":false,"name":"Pre-B-cell leukemia transcription factor-interacting protein 1","accession":"Q96AQ6","gene":"PBXIP1","description":"Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8017139810006922,"antibodyCount":110,"monoclonalCount":7,"pubmedCount":null,"jensenScore":8.755112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":65,"knowledgeAvailability":37.971357096207534,"pubTatorScore":1.40214595658361,"self":"https://pharos.nih.gov/idg/api/v1/targets(13771)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/publications"},"_namespace":null},{"id":13772,"version":3,"created":1554967223000,"modified":1555041578000,"deprecated":false,"name":"Exosome complex component RRP43","accession":"Q96B26","gene":"EXOSC8","description":"Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4405645348788028,"antibodyCount":87,"monoclonalCount":23,"pubmedCount":null,"jensenScore":25.607471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":34.55040704459835,"pubTatorScore":1.547662820163121,"self":"https://pharos.nih.gov/idg/api/v1/targets(13772)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/publications"},"_namespace":null},{"id":13773,"version":3,"created":1554967228000,"modified":1555041581000,"deprecated":false,"name":"Rho-related GTP-binding protein RhoD","accession":"O00212","gene":"RHOD","description":"Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1925062386321597,"antibodyCount":118,"monoclonalCount":19,"pubmedCount":null,"jensenScore":159.213048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":33.82611030139532,"pubTatorScore":1.4564477365832693,"self":"https://pharos.nih.gov/idg/api/v1/targets(13773)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/properties"},"_links":{"count":853,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/publications"},"_namespace":null},{"id":13774,"version":2,"created":1554967232000,"modified":1554967234000,"deprecated":false,"name":"Protein FAM131C","accession":"Q96AQ9","gene":"FAM131C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":35,"monoclonalCount":14,"pubmedCount":null,"jensenScore":0.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.807435328614307,"pubTatorScore":-1.1461254299191639,"self":"https://pharos.nih.gov/idg/api/v1/targets(13774)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/properties"},"_links":{"count":687,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/publications"},"_namespace":null},{"id":13775,"version":3,"created":1554967234000,"modified":1555041582000,"deprecated":false,"name":"Mitochondrial calcium uniporter regulator 1","accession":"Q96AQ8","gene":"MCUR1","description":"Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). 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Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7243113303243157,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.386462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.98065173076965,"pubTatorScore":0.7429868071580736,"self":"https://pharos.nih.gov/idg/api/v1/targets(13775)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/publications"},"_namespace":null},{"id":13776,"version":3,"created":1554967238000,"modified":1555041588000,"deprecated":false,"name":"Galectin-8","accession":"O00214","gene":"LGALS8","description":"Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). 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Required in the control of cell shape and migration.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8096035827649,"antibodyCount":152,"monoclonalCount":37,"pubmedCount":null,"jensenScore":71.139153,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":42.857562718470696,"pubTatorScore":1.8347545179289002,"self":"https://pharos.nih.gov/idg/api/v1/targets(13784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/publications"},"_namespace":null},{"id":13785,"version":2,"created":1554967273000,"modified":1554967273000,"deprecated":false,"name":"Protein FAM240B","accession":"A0A1B0GVZ2","gene":"FAM240B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/properties"},"_links":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/publications"},"_namespace":null},{"id":13786,"version":2,"created":1554967273000,"modified":1554967277000,"deprecated":false,"name":"Ras-related protein Rab-37","accession":"Q96AX2","gene":"RAB37","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9955261339304201,"antibodyCount":241,"monoclonalCount":123,"pubmedCount":null,"jensenScore":10.255168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.17604080599497,"pubTatorScore":0.9502341081631738,"self":"https://pharos.nih.gov/idg/api/v1/targets(13786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/publications"},"_namespace":null},{"id":13787,"version":2,"created":1554967278000,"modified":1554967282000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 33A","accession":"Q96AX1","gene":"VPS33A","description":"Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9426560095064573,"antibodyCount":45,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.41823,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.44502637538357,"pubTatorScore":0.6367460894019311,"self":"https://pharos.nih.gov/idg/api/v1/targets(13787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/publications"},"_namespace":null},{"id":13788,"version":3,"created":1554967282000,"modified":1555041595000,"deprecated":false,"name":"TATA box-binding protein-associated factor RNA polymerase I subunit D","accession":"Q9H5J8","gene":"TAF1D","description":"Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. 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Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.2710667688121821,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.88952,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.773578939192102,"pubTatorScore":-0.2041199826559248,"self":"https://pharos.nih.gov/idg/api/v1/targets(13788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/publications"},"_namespace":null},{"id":13789,"version":3,"created":1554967286000,"modified":1555041598000,"deprecated":false,"name":"Spermatogenesis-associated protein 19, mitochondrial","accession":"Q7Z5L4","gene":"SPATA19","description":"May have a role in spermiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0256958786975765,"antibodyCount":82,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.686975,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":15.160518111625569,"pubTatorScore":1.0528038287600496,"self":"https://pharos.nih.gov/idg/api/v1/targets(13789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/properties"},"_links":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/publications"},"_namespace":null},{"id":13790,"version":2,"created":1554967289000,"modified":1554967290000,"deprecated":false,"name":"Complement C1q-like protein 2","accession":"Q7Z5L3","gene":"C1QL2","description":"May regulate the number of excitatory synapses that are formed on hippocampus neurons. 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Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5209384600957747,"antibodyCount":139,"monoclonalCount":3,"pubmedCount":null,"jensenScore":31.55451,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.24264246281398,"pubTatorScore":1.325773331244391,"self":"https://pharos.nih.gov/idg/api/v1/targets(13806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/publications"},"_namespace":null},{"id":13807,"version":3,"created":1554967383000,"modified":1555041605000,"deprecated":false,"name":"Transmembrane protein 186","accession":"Q96B77","gene":"TMEM186","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":25.638709279815917,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/publications"},"_namespace":null},{"id":13808,"version":2,"created":1554967386000,"modified":1554967390000,"deprecated":false,"name":"Fibronectin type III domain-containing protein 1","accession":"Q4ZHG4","gene":"FNDC1","description":"May be an activator of G protein signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8614063746188663,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.421777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.074324344955535,"pubTatorScore":0.7169882415191436,"self":"https://pharos.nih.gov/idg/api/v1/targets(13808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/publications"},"_namespace":null},{"id":13809,"version":3,"created":1554967391000,"modified":1555041606000,"deprecated":false,"name":"Wings apart-like protein homolog","accession":"Q7Z5K2","gene":"WAPL","description":"Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3902050293220225,"antibodyCount":125,"monoclonalCount":26,"pubmedCount":null,"jensenScore":215.188029,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.8652358249148278,"self":"https://pharos.nih.gov/idg/api/v1/targets(13809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/properties"},"_links":{"count":1065,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/publications"},"_namespace":null},{"id":13810,"version":3,"created":1554967396000,"modified":1555041607000,"deprecated":false,"name":"Disabled homolog 2-interacting protein","accession":"Q5VWQ8","gene":"DAB2IP","description":"Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.691928208412532,"antibodyCount":59,"monoclonalCount":6,"pubmedCount":null,"jensenScore":60.308144,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":42.75660279308065,"pubTatorScore":1.7117573286900758,"self":"https://pharos.nih.gov/idg/api/v1/targets(13810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/publications"},"_namespace":null},{"id":13811,"version":2,"created":1554967401000,"modified":1554967403000,"deprecated":false,"name":"T-complex-associated testis-expressed protein 1","accession":"Q5JU00","gene":"TCTE1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8513311573430256,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.32851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.10444104065499,"pubTatorScore":0.7029157444880845,"self":"https://pharos.nih.gov/idg/api/v1/targets(13811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/publications"},"_namespace":null},{"id":13812,"version":3,"created":1554967404000,"modified":1555041609000,"deprecated":false,"name":"Lysine-specific demethylase 9","accession":"Q5VWQ0","gene":"RSBN1","description":"Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4122532155800742,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.497442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":34.805642045870435,"pubTatorScore":0.38958776564918773,"self":"https://pharos.nih.gov/idg/api/v1/targets(13812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/publications"},"_namespace":null},{"id":13813,"version":2,"created":1554967410000,"modified":1554967414000,"deprecated":false,"name":"DNA-directed RNA polymerase III subunit RPC1","accession":"O14802","gene":"POLR3A","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2563178059934956,"antibodyCount":99,"monoclonalCount":1,"pubmedCount":null,"jensenScore":178.201892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.8882399157901,"pubTatorScore":1.6819443787336046,"self":"https://pharos.nih.gov/idg/api/v1/targets(13813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/publications"},"_namespace":null},{"id":13814,"version":2,"created":1554967415000,"modified":1554967417000,"deprecated":false,"name":"Trace amine-associated receptor 5","accession":"O14804","gene":"TAAR5","description":"Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.150483541136812,"antibodyCount":129,"monoclonalCount":2,"pubmedCount":null,"jensenScore":143.636975,"patentCount":10169,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.899880442196169,"pubTatorScore":1.6172318611617527,"self":"https://pharos.nih.gov/idg/api/v1/targets(13814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/properties"},"_links":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/publications"},"_namespace":null},{"id":13815,"version":3,"created":1554967417000,"modified":1555041610000,"deprecated":false,"name":"Ras-related protein M-Ras","accession":"O14807","gene":"MRAS","description":"May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4899539106709168,"antibodyCount":74,"monoclonalCount":12,"pubmedCount":null,"jensenScore":309.918464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.04974513673041,"pubTatorScore":1.352722560350065,"self":"https://pharos.nih.gov/idg/api/v1/targets(13815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/publications"},"_namespace":null},{"id":13816,"version":2,"created":1554967423000,"modified":1554967427000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 L3","accession":"P68036","gene":"UBE2L3","description":"Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7480052448703838,"antibodyCount":325,"monoclonalCount":30,"pubmedCount":null,"jensenScore":58.402047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.39284675288242,"pubTatorScore":1.8475703951294657,"self":"https://pharos.nih.gov/idg/api/v1/targets(13816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/properties"},"_links":{"count":1173,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/publications"},"_namespace":null},{"id":13817,"version":2,"created":1554967428000,"modified":1554967429000,"deprecated":false,"name":"Leukocyte receptor cluster member 9","accession":"Q96B70","gene":"LENG9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.877005219150313,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/properties"},"_links":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/publications"},"_namespace":null},{"id":13818,"version":2,"created":1554967430000,"modified":1554967432000,"deprecated":false,"name":"CWF19-like protein 2","accession":"Q2TBE0","gene":"CWF19L2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0,"antibodyCount":25,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.681231941811447,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(13818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/publications"},"_namespace":null},{"id":13819,"version":2,"created":1554967433000,"modified":1554967437000,"deprecated":false,"name":"Zinc finger protein 768","accession":"Q9H5H4","gene":"ZNF768","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0,"antibodyCount":105,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.041667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.26652336200845,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(13819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/publications"},"_namespace":null},{"id":13820,"version":3,"created":1554967437000,"modified":1555041612000,"deprecated":false,"name":"Transmembrane 4 L6 family member 20","accession":"Q53R12","gene":"TM4SF20","description":"Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":41,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.510684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":17.364744693144875,"pubTatorScore":0.31875869313729016,"self":"https://pharos.nih.gov/idg/api/v1/targets(13820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/properties"},"_links":{"count":616,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/publications"},"_namespace":null},{"id":13821,"version":2,"created":1554967440000,"modified":1554967441000,"deprecated":false,"name":"Prickle-like protein 4","accession":"Q2TBC4","gene":"PRICKLE4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3454491363571743,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.804733,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.508821796176903,"pubTatorScore":0.17849723284486796,"self":"https://pharos.nih.gov/idg/api/v1/targets(13821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/properties"},"_links":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/publications"},"_namespace":null},{"id":13822,"version":3,"created":1554967441000,"modified":1555041614000,"deprecated":false,"name":"Arrestin domain-containing protein 3","accession":"Q96B67","gene":"ARRDC3","description":"Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). 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Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. 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May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0468073383699923,"antibodyCount":157,"monoclonalCount":8,"pubmedCount":null,"jensenScore":115.675415,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.55751815674542,"pubTatorScore":1.8087112242882877,"self":"https://pharos.nih.gov/idg/api/v1/targets(13830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/publications"},"_namespace":null},{"id":13831,"version":2,"created":1554967484000,"modified":1554967494000,"deprecated":false,"name":"Protein ALEX","accession":"P84996","gene":"GNAS","description":"May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6335564959942657,"antibodyCount":509,"monoclonalCount":63,"pubmedCount":null,"jensenScore":1389.742966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.128609119577192,"self":"https://pharos.nih.gov/idg/api/v1/targets(13831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/properties"},"_links":{"count":1657,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/synonyms"},"_publications":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/publications"},"_namespace":null},{"id":13832,"version":3,"created":1554967497000,"modified":1555041615000,"deprecated":false,"name":"Complexin-1","accession":"O14810","gene":"CPLX1","description":"Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.927299493699394,"antibodyCount":106,"monoclonalCount":3,"pubmedCount":null,"jensenScore":82.007106,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.12017829903576,"pubTatorScore":1.4188764333865074,"self":"https://pharos.nih.gov/idg/api/v1/targets(13832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/publications"},"_namespace":null},{"id":13833,"version":3,"created":1554967502000,"modified":1555041616000,"deprecated":false,"name":"Fibulin-7","accession":"Q53RD9","gene":"FBLN7","description":"An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2401330297413644,"antibodyCount":105,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.718226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":20.921314014305047,"pubTatorScore":0.8672709796627784,"self":"https://pharos.nih.gov/idg/api/v1/targets(13833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/publications"},"_namespace":null},{"id":13834,"version":3,"created":1554967506000,"modified":1555041617000,"deprecated":false,"name":"Protein FAM149B1","accession":"Q96BN6","gene":"FAM149B1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":25,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.442179985526945,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(13834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/properties"},"_links":{"count":822,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/publications"},"_namespace":null},{"id":13835,"version":3,"created":1554967509000,"modified":1555041618000,"deprecated":false,"name":"Ubiquitin thioesterase otulin","accession":"Q96BN8","gene":"OTULIN","description":"Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327). 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Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. 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Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (PubMed:20068034). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.067993759331336,"antibodyCount":232,"monoclonalCount":46,"pubmedCount":null,"jensenScore":109.663318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.460767761876944,"pubTatorScore":2.6894061293056843,"self":"https://pharos.nih.gov/idg/api/v1/targets(14184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":635,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/properties"},"_links":{"count":1211,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/publications"},"_namespace":null},{"id":14185,"version":2,"created":1554972257000,"modified":1554972258000,"deprecated":false,"name":"Olfactory receptor 7C2","accession":"O60412","gene":"OR7C2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":862,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.422989491053507,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(14185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/properties"},"_links":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/publications"},"_namespace":null},{"id":14186,"version":2,"created":1554972258000,"modified":1554972263000,"deprecated":false,"name":"Cation-dependent mannose-6-phosphate receptor","accession":"P20645","gene":"M6PR","description":"Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. 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PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). 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The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). 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Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1890504798822465,"antibodyCount":80,"monoclonalCount":33,"pubmedCount":null,"jensenScore":12.466161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.33789851428139,"pubTatorScore":1.096841041567853,"self":"https://pharos.nih.gov/idg/api/v1/targets(14311)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/publications"},"_namespace":null},{"id":14312,"version":2,"created":1554973149000,"modified":1554973153000,"deprecated":false,"name":"Leukocyte immunoglobulin-like receptor subfamily B member 2","accession":"Q8N423","gene":"LILRB2","description":"Receptor for class I MHC antigens. 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Functions predominantly in APPL1-containing endosomes (PubMed:25266290).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.138678547195401,"antibodyCount":61,"monoclonalCount":10,"pubmedCount":null,"jensenScore":12.681565,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.28942098226491,"pubTatorScore":0.2825466654994366,"self":"https://pharos.nih.gov/idg/api/v1/targets(14314)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/publications"},"_namespace":null},{"id":14315,"version":3,"created":1554973163000,"modified":1555041947000,"deprecated":false,"name":"Protein Wnt-7a","accession":"O00755","gene":"WNT7A","description":"Ligand for members of the frizzled family of seven transmembrane receptors. 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Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. 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May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.323852573270847,"antibodyCount":297,"monoclonalCount":84,"pubmedCount":null,"jensenScore":217.093876,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.99858235890262,"pubTatorScore":2.0562437522235584,"self":"https://pharos.nih.gov/idg/api/v1/targets(14324)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/publications"},"_namespace":null},{"id":14325,"version":2,"created":1554973222000,"modified":1554973226000,"deprecated":false,"name":"LIM domain-containing protein ajuba","accession":"Q96IF1","gene":"AJUBA","description":"Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. 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In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. 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Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8430966524567765,"antibodyCount":241,"monoclonalCount":40,"pubmedCount":null,"jensenScore":69.149843,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.47412042746375,"pubTatorScore":2.7071899884390125,"self":"https://pharos.nih.gov/idg/api/v1/targets(14472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":641,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/properties"},"_links":{"count":1257,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/synonyms"},"_publications":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/publications"},"_namespace":null},{"id":14473,"version":3,"created":1554975350000,"modified":1555042032000,"deprecated":false,"name":"Antigen peptide transporter 2","accession":"Q03519","gene":"TAP2","description":"Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. 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Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.226641772779147,"antibodyCount":160,"monoclonalCount":8,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.09504275073112,"pubTatorScore":2.4708471886482535,"self":"https://pharos.nih.gov/idg/api/v1/targets(14473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/properties"},"_links":{"count":1104,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/synonyms"},"_publications":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/publications"},"_namespace":null},{"id":14474,"version":3,"created":1554975357000,"modified":1555042036000,"deprecated":false,"name":"Ensconsin","accession":"Q14244","gene":"MAP7","description":"Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. 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Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1561632437299254,"antibodyCount":503,"monoclonalCount":185,"pubmedCount":null,"jensenScore":1465.003886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.28394399103345,"pubTatorScore":3.187660117143953,"self":"https://pharos.nih.gov/idg/api/v1/targets(14475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/properties"},"_links":{"count":1632,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/links"},"_synonyms":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/synonyms"},"_publications":{"count":704,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/publications"},"_namespace":null},{"id":14476,"version":2,"created":1554975375000,"modified":1554975379000,"deprecated":false,"name":"TATA box-binding protein-associated factor RNA polymerase I subunit A","accession":"Q15573","gene":"TAF1A","description":"Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8415382347077386,"antibodyCount":161,"monoclonalCount":11,"pubmedCount":null,"jensenScore":6.459687,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.25882824771007,"pubTatorScore":1.9134732319692482,"self":"https://pharos.nih.gov/idg/api/v1/targets(14476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/publications"},"_namespace":null},{"id":14477,"version":3,"created":1554975380000,"modified":1555042041000,"deprecated":false,"name":"P-selectin glycoprotein ligand 1","accession":"Q14242","gene":"SELPLG","description":"(Microbial infection) Acts as a receptor for enterovirus 71.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7698884265008656,"antibodyCount":626,"monoclonalCount":391,"pubmedCount":null,"jensenScore":605.846724,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.88796478664111,"pubTatorScore":2.812912726581327,"self":"https://pharos.nih.gov/idg/api/v1/targets(14477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/synonyms"},"_publications":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/publications"},"_namespace":null},{"id":14478,"version":2,"created":1554975387000,"modified":1554975390000,"deprecated":false,"name":"Endonuclease G, mitochondrial","accession":"Q14249","gene":"ENDOG","description":"Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2279145785280057,"antibodyCount":334,"monoclonalCount":95,"pubmedCount":null,"jensenScore":175.852292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.58677701856338,"pubTatorScore":2.0375318712942025,"self":"https://pharos.nih.gov/idg/api/v1/targets(14478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/publications"},"_namespace":null},{"id":14479,"version":2,"created":1554975391000,"modified":1554975395000,"deprecated":false,"name":"Transmembrane protein 50B","accession":"P56557","gene":"TMEM50B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3197503022236352,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.96738,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.237095349424685,"pubTatorScore":-0.07748162063726477,"self":"https://pharos.nih.gov/idg/api/v1/targets(14479)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/publications"},"_namespace":null},{"id":14480,"version":3,"created":1554975396000,"modified":1555042043000,"deprecated":false,"name":"Src substrate cortactin","accession":"Q14247","gene":"CTTN","description":"Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). 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Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. 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Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2325725806264844,"antibodyCount":119,"monoclonalCount":4,"pubmedCount":null,"jensenScore":18.249816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.021973568009827,"pubTatorScore":1.143881804602326,"self":"https://pharos.nih.gov/idg/api/v1/targets(14544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/publications"},"_namespace":null},{"id":14545,"version":2,"created":1554975730000,"modified":1554975735000,"deprecated":false,"name":"Transmembrane protein 150C","accession":"B9EJG8","gene":"TMEM150C","description":"Component of a mechanosensitive cation channel. 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Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.3282376763515174,"antibodyCount":90,"monoclonalCount":4,"pubmedCount":null,"jensenScore":1.804249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.237729767542273,"pubTatorScore":0.15062843456746924,"self":"https://pharos.nih.gov/idg/api/v1/targets(14546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/publications"},"_namespace":null},{"id":14547,"version":2,"created":1554975740000,"modified":1554975743000,"deprecated":false,"name":"Angiomotin","accession":"Q4VCS5","gene":"AMOT","description":"Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. 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Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.931050155381126,"antibodyCount":560,"monoclonalCount":125,"pubmedCount":null,"jensenScore":922.425159,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":52.68108703071826,"pubTatorScore":2.881603512287583,"self":"https://pharos.nih.gov/idg/api/v1/targets(14550)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/properties"},"_links":{"count":1292,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/links"},"_synonyms":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/synonyms"},"_publications":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/publications"},"_namespace":null},{"id":14551,"version":2,"created":1554975964000,"modified":1554975966000,"deprecated":false,"name":"Retina and anterior neural fold homeobox protein 2","accession":"Q96IS3","gene":"RAX2","description":"May be involved in modulating the expression of photoreceptor specific genes. 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Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). 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Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. 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Binds to LGALS3 at the maternal-fetal interface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.188420972902821,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":160.999561,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.41146385108075,"pubTatorScore":2.055399609754129,"self":"https://pharos.nih.gov/idg/api/v1/targets(14654)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/publications"},"_namespace":null},{"id":14655,"version":3,"created":1554977062000,"modified":1554977159000,"deprecated":false,"name":"Glucagon-like peptide 1 receptor","accession":"P43220","gene":"GLP1R","description":"G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.9205944264163497,"antibodyCount":306,"monoclonalCount":38,"pubmedCount":null,"jensenScore":820.537935,"patentCount":21409,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.031878799868995,"pubTatorScore":2.928823700619351,"self":"https://pharos.nih.gov/idg/api/v1/targets(14655)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/synonyms"},"_publications":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/publications"},"_namespace":null},{"id":14656,"version":2,"created":1554977161000,"modified":1554977162000,"deprecated":false,"name":"Aquaporin-12B","accession":"A6NM10","gene":"AQP12B","description":"Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9513774851947907,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.845799,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.094502463123787,"pubTatorScore":-0.33881887240402814,"self":"https://pharos.nih.gov/idg/api/v1/targets(14656)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/properties"},"_links":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/publications"},"_namespace":null},{"id":14657,"version":3,"created":1554977162000,"modified":1555042161000,"deprecated":false,"name":"Sorting nexin-3","accession":"O60493","gene":"SNX3","description":"Phosphoinositide-binding protein required for multivesicular body formation. 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Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3422968231479846,"antibodyCount":225,"monoclonalCount":22,"pubmedCount":null,"jensenScore":23.532681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.650619945405836,"pubTatorScore":1.2918500378480666,"self":"https://pharos.nih.gov/idg/api/v1/targets(14657)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/publications"},"_namespace":null},{"id":14658,"version":2,"created":1554977167000,"modified":1554977169000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 37A2","accession":"A6NM11","gene":"LRRC37A2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2509511318514679,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.46978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.633698331214951,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(14658)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/publications"},"_namespace":null},{"id":14659,"version":2,"created":1554977170000,"modified":1554977174000,"deprecated":false,"name":"Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase","accession":"Q96IV0","gene":"NGLY1","description":"Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. 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Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9261475338408427,"antibodyCount":32,"monoclonalCount":2,"pubmedCount":null,"jensenScore":77.4055,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.5625172992021,"pubTatorScore":2.1461078001860665,"self":"https://pharos.nih.gov/idg/api/v1/targets(14659)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/publications"},"_namespace":null},{"id":14660,"version":2,"created":1554977174000,"modified":1554977175000,"deprecated":false,"name":"Protein SPHAR","accession":"Q15513","gene":"SPHAR","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0440168087172985,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.783521,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.251524305581867,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(14660)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/properties"},"_links":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/publications"},"_namespace":null},{"id":14661,"version":2,"created":1554977175000,"modified":1554977180000,"deprecated":false,"name":"Calcium-independent phospholipase A2-gamma","accession":"Q9NP80","gene":"PNPLA8","description":"Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. 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Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.889093942299386,"antibodyCount":217,"monoclonalCount":37,"pubmedCount":null,"jensenScore":755.511785,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":29.404438585495924,"pubTatorScore":2.778329617580642,"self":"https://pharos.nih.gov/idg/api/v1/targets(14663)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/publications"},"_namespace":null},{"id":14664,"version":3,"created":1554977193000,"modified":1555042166000,"deprecated":false,"name":"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2","accession":"Q16842","gene":"ST3GAL2","description":"Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. 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Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.070524875106741,"antibodyCount":2150,"monoclonalCount":488,"pubmedCount":null,"jensenScore":1137.418473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":69.73951691819548,"pubTatorScore":3.506345550350962,"self":"https://pharos.nih.gov/idg/api/v1/targets(14800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1522,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/properties"},"_links":{"count":1882,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/links"},"_synonyms":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/synonyms"},"_publications":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/publications"},"_namespace":null},{"id":14801,"version":2,"created":1554978264000,"modified":1554978268000,"deprecated":false,"name":"Twisted gastrulation protein homolog 1","accession":"Q9GZX9","gene":"TWSG1","description":"May be involved in dorsoventral axis formation. 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May play a role in thymocyte development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.472091827443325,"antibodyCount":79,"monoclonalCount":43,"pubmedCount":null,"jensenScore":291.948333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.53946330715206,"pubTatorScore":1.8381888769631118,"self":"https://pharos.nih.gov/idg/api/v1/targets(14801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/publications"},"_namespace":null},{"id":14802,"version":2,"created":1554978269000,"modified":1554978273000,"deprecated":false,"name":"SUMO-activating enzyme subunit 1","accession":"Q9UBE0","gene":"SAE1","description":"The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. 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At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.317362220290323,"antibodyCount":260,"monoclonalCount":41,"pubmedCount":null,"jensenScore":223.472836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.66547450830746,"pubTatorScore":2.2032548021362772,"self":"https://pharos.nih.gov/idg/api/v1/targets(14809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":589,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/synonyms"},"_publications":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/publications"},"_namespace":null},{"id":14810,"version":2,"created":1554978305000,"modified":1554978305000,"deprecated":false,"name":"Putative gap junction epsilon-1 protein","accession":"A6NN92","gene":"GJE1","description":"Mediates calcium-independent ATP release, suggesting activity as a hemichannel. 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May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.851526912589436,"antibodyCount":302,"monoclonalCount":68,"pubmedCount":null,"jensenScore":635.262725,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.810967728906476,"pubTatorScore":3.815575014053383,"self":"https://pharos.nih.gov/idg/api/v1/targets(14812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/synonyms"},"_publications":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/publications"},"_namespace":null},{"id":14813,"version":3,"created":1554978312000,"modified":1555042250000,"deprecated":false,"name":"Carbohydrate sulfotransferase 6","accession":"Q9GZX3","gene":"CHST6","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. 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May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. 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Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3256481913451006,"antibodyCount":128,"monoclonalCount":36,"pubmedCount":null,"jensenScore":21.65909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.39930299773658,"pubTatorScore":2.2052087935126647,"self":"https://pharos.nih.gov/idg/api/v1/targets(14860)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/publications"},"_namespace":null},{"id":14861,"version":2,"created":1554978652000,"modified":1554978652000,"deprecated":false,"name":"Olfactory receptor 4C45","accession":"A6NMZ5","gene":"OR4C45","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.921718895272711,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(14861)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/publications"},"_namespace":null},{"id":14862,"version":2,"created":1554978652000,"modified":1554978654000,"deprecated":false,"name":"Zinc finger protein 613","accession":"Q6PF04","gene":"ZNF613","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":88,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.55139462223416,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(14862)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/publications"},"_namespace":null},{"id":14863,"version":4,"created":1554978655000,"modified":1555042286000,"deprecated":false,"name":"Casein kinase II subunit alpha'","accession":"P19784","gene":"CSNK2A2","description":"Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. 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Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.341677549924326,"antibodyCount":218,"monoclonalCount":36,"pubmedCount":null,"jensenScore":221.259226,"patentCount":7051,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":46.92641101964884,"pubTatorScore":1.416171015943221,"self":"https://pharos.nih.gov/idg/api/v1/targets(14863)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":516,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/synonyms"},"_publications":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/publications"},"_namespace":null},{"id":14864,"version":2,"created":1554978694000,"modified":1554978700000,"deprecated":false,"name":"Methyl-CpG-binding domain protein 4","accession":"O95243","gene":"MBD4","description":"Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.996252618074547,"antibodyCount":183,"monoclonalCount":3,"pubmedCount":null,"jensenScore":98.642614,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.544413343713124,"pubTatorScore":1.88954997512218,"self":"https://pharos.nih.gov/idg/api/v1/targets(14864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/properties"},"_links":{"count":1082,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/publications"},"_namespace":null},{"id":14865,"version":2,"created":1554978701000,"modified":1554978706000,"deprecated":false,"name":"Ammonium transporter Rh type A","accession":"Q02094","gene":"RHAG","description":"Associated with rhesus blood group antigen expression (PubMed:19744193). May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane (PubMed:11062476, PubMed:11861637). Involved in ammonia transport across the erythrocyte membrane (PubMed:21849667, PubMed:22012326). 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Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (PubMed:20457893). Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation (PubMed:20457893). In a complex with coregulator RCCD1, is also able to demethylate trimethylated 'Lys-36' (H3K36me3) of histone H3 (PubMed:24981860). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1 (PubMed:24981860). Possibly together with RCCD1, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability (PubMed:28455245). Might function as a protein hydroxylase (PubMed:22851697, PubMed:24100311). Under stress conditions that cause a DNA damage response, acts as a histone protease by cleaving the N-terminal tail of histone H3 at the carboxyl side of monomethyl-lysine (Kme1) residues, preferably at monomethylated 'Lys-9' (H3K9me1) (PubMed:28982940). The histone variant H3F3A is the major target for cleavage (PubMed:28982940).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.6820053641650512,"antibodyCount":209,"monoclonalCount":17,"pubmedCount":null,"jensenScore":49.631656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.85232522083663,"pubTatorScore":1.1075092243512528,"self":"https://pharos.nih.gov/idg/api/v1/targets(14868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/publications"},"_namespace":null},{"id":14869,"version":2,"created":1554978719000,"modified":1554978726000,"deprecated":false,"name":"Collagen alpha-6(VI) chain","accession":"A6NMZ7","gene":"COL6A6","description":"Collagen VI acts as a cell-binding protein.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.48745262289592867,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.275,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.413633842533265,"pubTatorScore":0.15103534228890542,"self":"https://pharos.nih.gov/idg/api/v1/targets(14869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/publications"},"_namespace":null},{"id":14870,"version":2,"created":1554978727000,"modified":1554978732000,"deprecated":false,"name":"ADP/ATP translocase 2","accession":"P05141","gene":"SLC25A5","description":"Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. 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May be involved in muscle-specific and/or growth factor-related transcription.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.390107235869541,"antibodyCount":113,"monoclonalCount":41,"pubmedCount":null,"jensenScore":19.976941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(14873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/publications"},"_namespace":null},{"id":14874,"version":3,"created":1554978742000,"modified":1555042289000,"deprecated":false,"name":"T-cell surface glycoprotein CD3 epsilon chain","accession":"P07766","gene":"CD3E","description":"Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.2521564430517054,"antibodyCount":2406,"monoclonalCount":1819,"pubmedCount":null,"jensenScore":172.570359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.13467090311029,"pubTatorScore":2.2871060444133247,"self":"https://pharos.nih.gov/idg/api/v1/targets(14874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/synonyms"},"_publications":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/publications"},"_namespace":null},{"id":14875,"version":2,"created":1554978746000,"modified":1554978761000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily H member 1","accession":"O95259","gene":"KCNH1","description":"Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.8611133710870855,"antibodyCount":150,"monoclonalCount":6,"pubmedCount":null,"jensenScore":714.162763,"patentCount":19282,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.21170359721087,"pubTatorScore":2.3460585325537284,"self":"https://pharos.nih.gov/idg/api/v1/targets(14875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/publications"},"_namespace":null},{"id":14876,"version":3,"created":1554978762000,"modified":1555042290000,"deprecated":false,"name":"Interleukin-18 receptor accessory protein","accession":"O95256","gene":"IL18RAP","description":"Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5309273833457395,"antibodyCount":249,"monoclonalCount":72,"pubmedCount":null,"jensenScore":27.625909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.934326652022055,"pubTatorScore":1.5515448980268483,"self":"https://pharos.nih.gov/idg/api/v1/targets(14876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/properties"},"_links":{"count":804,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/publications"},"_namespace":null},{"id":14877,"version":3,"created":1554978767000,"modified":1555042292000,"deprecated":false,"name":"Integrin beta-3","accession":"P05106","gene":"ITGB3","description":"(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB3 acts as a receptor for coxsackievirus A9 (PubMed:7519807). Acts as a receptor for Hantaan virus (PubMed:9618541). Integrin ITGAV:ITGB3 acts as a receptor for cytomegalovirus/HHV-5 (PubMed:15834425). Integrin ITGA5:ITGB3 acts as a receptor for human metapneumovirus (PubMed:24478423). Integrin ITGAV:ITGB3 acts aP05556s a receptor for human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for west nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.04474531717982,"antibodyCount":1517,"monoclonalCount":879,"pubmedCount":null,"jensenScore":986.940542,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":58.464467164929005,"pubTatorScore":3.05104647988221,"self":"https://pharos.nih.gov/idg/api/v1/targets(14877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1520,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/properties"},"_links":{"count":1792,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/links"},"_synonyms":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/synonyms"},"_publications":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/publications"},"_namespace":null},{"id":14878,"version":3,"created":1554978781000,"modified":1555042297000,"deprecated":false,"name":"Integrin beta-2","accession":"P05107","gene":"ITGB2","description":"Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.4040487789863554,"antibodyCount":1411,"monoclonalCount":970,"pubmedCount":null,"jensenScore":232.107205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":51.577807103146164,"pubTatorScore":3.095597565306178,"self":"https://pharos.nih.gov/idg/api/v1/targets(14878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":841,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/properties"},"_links":{"count":1427,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/links"},"_synonyms":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/synonyms"},"_publications":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/publications"},"_namespace":null},{"id":14879,"version":3,"created":1554978792000,"modified":1555042300000,"deprecated":false,"name":"Growth arrest and DNA damage-inducible protein GADD45 gamma","accession":"O95257","gene":"GADD45G","description":"Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4544442561660955,"antibodyCount":567,"monoclonalCount":362,"pubmedCount":null,"jensenScore":286.799255,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.22967948842283,"pubTatorScore":1.6018044858832998,"self":"https://pharos.nih.gov/idg/api/v1/targets(14879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/publications"},"_namespace":null},{"id":14880,"version":3,"created":1554978795000,"modified":1555042302000,"deprecated":false,"name":"Cholesterol side-chain cleavage enzyme, mitochondrial","accession":"P05108","gene":"CYP11A1","description":"Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.936561552246959,"antibodyCount":296,"monoclonalCount":4,"pubmedCount":null,"jensenScore":785.324204,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.583463911571066,"pubTatorScore":2.7593251546506203,"self":"https://pharos.nih.gov/idg/api/v1/targets(14880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/publications"},"_namespace":null},{"id":14881,"version":3,"created":1554978809000,"modified":1555042303000,"deprecated":false,"name":"Protein S100-A8","accession":"P05109","gene":"S100A8","description":"S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. 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Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.3142430389713395,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":19.223421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.7338635805298,"pubTatorScore":1.6386242865691485,"self":"https://pharos.nih.gov/idg/api/v1/targets(15137)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/publications"},"_namespace":null},{"id":15138,"version":2,"created":1554980518000,"modified":1554980524000,"deprecated":false,"name":"Splicing factor 3B subunit 4","accession":"Q15427","gene":"SF3B4","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4441632884845679,"antibodyCount":222,"monoclonalCount":38,"pubmedCount":null,"jensenScore":28.695034,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.98212851689296,"pubTatorScore":1.3633950981167053,"self":"https://pharos.nih.gov/idg/api/v1/targets(15138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/publications"},"_namespace":null},{"id":15139,"version":3,"created":1554980525000,"modified":1555042479000,"deprecated":false,"name":"Serine/threonine-protein kinase haspin","accession":"Q8TF76","gene":"HASPIN","description":"Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.703908544997451,"antibodyCount":120,"monoclonalCount":5,"pubmedCount":null,"jensenScore":49.987513,"patentCount":2918,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":0.0,"pubTatorScore":1.528631064169227,"self":"https://pharos.nih.gov/idg/api/v1/targets(15139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/publications"},"_namespace":null},{"id":15140,"version":2,"created":1554980530000,"modified":1554980534000,"deprecated":false,"name":"EH domain-binding protein 1-like protein 1","accession":"Q8N3D4","gene":"EHBP1L1","description":"May act as Rab effector protein and play a role in vesicle trafficking.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.237574345794961,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.733168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.27356203924023,"pubTatorScore":0.02802885931724794,"self":"https://pharos.nih.gov/idg/api/v1/targets(15140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/publications"},"_namespace":null},{"id":15141,"version":2,"created":1554980534000,"modified":1554980539000,"deprecated":false,"name":"Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial","accession":"Q96HY7","gene":"DHTKD1","description":"The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9660634766671389,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.644047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.23433936823812,"pubTatorScore":0.9259992492903653,"self":"https://pharos.nih.gov/idg/api/v1/targets(15141)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/publications"},"_namespace":null},{"id":15142,"version":2,"created":1554980540000,"modified":1554980541000,"deprecated":false,"name":"Smith-Magenis syndrome chromosomal region candidate gene 5 protein","accession":"Q8TEV8","gene":"SMCR5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.057430212581303,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(15142)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/publications"},"_namespace":null},{"id":15143,"version":2,"created":1554980541000,"modified":1554980544000,"deprecated":false,"name":"Guanine nucleotide exchange protein SMCR8","accession":"Q8TEV9","gene":"SMCR8","description":"Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5788301567619928,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.028096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.427461381650836,"pubTatorScore":0.19299206263748017,"self":"https://pharos.nih.gov/idg/api/v1/targets(15143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/publications"},"_namespace":null},{"id":15144,"version":3,"created":1554980545000,"modified":1555042480000,"deprecated":false,"name":"SUMO-activating enzyme subunit 2","accession":"Q9UBT2","gene":"UBA2","description":"The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. 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Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.421421526752512,"antibodyCount":224,"monoclonalCount":37,"pubmedCount":null,"jensenScore":256.317154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.10252999555352,"pubTatorScore":2.1526195388794203,"self":"https://pharos.nih.gov/idg/api/v1/targets(15147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/links"},"_synonyms":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/publications"},"_namespace":null},{"id":15148,"version":2,"created":1554980565000,"modified":1554980569000,"deprecated":false,"name":"Zinc finger protein 415","accession":"Q09FC8","gene":"ZNF415","description":"Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.003113233438796746,"antibodyCount":116,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.161039,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.989107715702552,"pubTatorScore":-0.07058107428570728,"self":"https://pharos.nih.gov/idg/api/v1/targets(15148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/publications"},"_namespace":null},{"id":15149,"version":3,"created":1554980570000,"modified":1555042482000,"deprecated":false,"name":"Dickkopf-related protein 4","accession":"Q9UBT3","gene":"DKK4","description":"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4323245605146708,"antibodyCount":316,"monoclonalCount":26,"pubmedCount":null,"jensenScore":27.423218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":22.424399848599453,"pubTatorScore":1.4291683346579616,"self":"https://pharos.nih.gov/idg/api/v1/targets(15149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/properties"},"_links":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/publications"},"_namespace":null},{"id":15150,"version":3,"created":1554980573000,"modified":1555042483000,"deprecated":false,"name":"Enoyl-CoA hydratase, mitochondrial","accession":"P30084","gene":"ECHS1","description":"Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6963687858462566,"antibodyCount":162,"monoclonalCount":17,"pubmedCount":null,"jensenScore":49.537852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.04774050600639,"pubTatorScore":1.4453446853869458,"self":"https://pharos.nih.gov/idg/api/v1/targets(15150)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":494,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/publications"},"_namespace":null},{"id":15151,"version":2,"created":1554980579000,"modified":1554980584000,"deprecated":false,"name":"Thiosulfate sulfurtransferase","accession":"Q16762","gene":"TST","description":"Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. 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Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.433065445630572,"antibodyCount":173,"monoclonalCount":5,"pubmedCount":null,"jensenScore":261.217234,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.042241347234025,"pubTatorScore":2.2071740513922724,"self":"https://pharos.nih.gov/idg/api/v1/targets(15271)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/publications"},"_namespace":null},{"id":15272,"version":2,"created":1554981414000,"modified":1554981418000,"deprecated":false,"name":"SERTA domain-containing protein 2","accession":"Q14140","gene":"SERTAD2","description":"Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. 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Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8012239931119279,"antibodyCount":119,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.349285,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.27043389330013,"pubTatorScore":0.8175508928357705,"self":"https://pharos.nih.gov/idg/api/v1/targets(15272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/publications"},"_namespace":null},{"id":15273,"version":3,"created":1554981419000,"modified":1555042583000,"deprecated":false,"name":"Dickkopf-related protein 3","accession":"Q9UBP4","gene":"DKK3","description":"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. 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Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. 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Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. 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Regulates the expression of CCNA1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.640407335282206,"antibodyCount":111,"monoclonalCount":23,"pubmedCount":null,"jensenScore":433.691538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":41.529668921731584,"pubTatorScore":2.363243464783708,"self":"https://pharos.nih.gov/idg/api/v1/targets(15279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/publications"},"_namespace":null},{"id":15280,"version":2,"created":1554981467000,"modified":1554981472000,"deprecated":false,"name":"Cyclic AMP-responsive element-binding protein 3-like protein 4","accession":"Q8TEY5","gene":"CREB3L4","description":"Transcriptional activator that may play a role in the unfolded protein response. 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Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6487532841263153,"antibodyCount":188,"monoclonalCount":33,"pubmedCount":null,"jensenScore":47.58176,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.77448115926723,"pubTatorScore":1.1560696485140647,"self":"https://pharos.nih.gov/idg/api/v1/targets(15280)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/publications"},"_namespace":null},{"id":15281,"version":2,"created":1554981472000,"modified":1554981476000,"deprecated":false,"name":"MORC family CW-type zinc finger protein 3","accession":"Q14149","gene":"MORC3","description":"Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). 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May be required for influenza A transcription during viral infection (PubMed:26202233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6124083804093996,"antibodyCount":61,"monoclonalCount":8,"pubmedCount":null,"jensenScore":36.603589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.36505231059523,"pubTatorScore":1.344937805667503,"self":"https://pharos.nih.gov/idg/api/v1/targets(15281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/publications"},"_namespace":null},{"id":15282,"version":3,"created":1554981477000,"modified":1555042588000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 33","accession":"Q8TEY7","gene":"USP33","description":"Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. 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Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. 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The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. 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Acts as an attachment receptor for west-nile virus (PubMed:16415006). Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.800617862013195,"antibodyCount":983,"monoclonalCount":644,"pubmedCount":null,"jensenScore":714.528479,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":30.699356789885904,"pubTatorScore":2.5482612522513004,"self":"https://pharos.nih.gov/idg/api/v1/targets(15368)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":612,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/properties"},"_links":{"count":1214,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/links"},"_synonyms":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/synonyms"},"_publications":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/publications"},"_namespace":null},{"id":15369,"version":3,"created":1554981918000,"modified":1555042645000,"deprecated":false,"name":"Far upstream element-binding protein 3","accession":"Q96I24","gene":"FUBP3","description":"May interact with single-stranded DNA from the far-upstream element (FUSE). 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Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. 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The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.915212881282686,"antibodyCount":692,"monoclonalCount":160,"pubmedCount":null,"jensenScore":803.446597,"patentCount":44319,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":52.907734265074666,"pubTatorScore":2.709055229859793,"self":"https://pharos.nih.gov/idg/api/v1/targets(15670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":711,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/properties"},"_links":{"count":1943,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/synonyms"},"_publications":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/publications"},"_namespace":null},{"id":15671,"version":3,"created":1554984382000,"modified":1555042845000,"deprecated":false,"name":"Polycomb protein SCMH1","accession":"Q96GD3","gene":"SCMH1","description":"Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.5657087819232881,"antibodyCount":140,"monoclonalCount":50,"pubmedCount":null,"jensenScore":4.103939,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.41030228875138,"pubTatorScore":0.45014113729906857,"self":"https://pharos.nih.gov/idg/api/v1/targets(15671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/publications"},"_namespace":null},{"id":15672,"version":2,"created":1554984386000,"modified":1554984389000,"deprecated":false,"name":"C-type lectin domain family 4 member F","accession":"Q8N1N0","gene":"CLEC4F","description":"Receptor with an affinity for galactose and fucose. 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The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). 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In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.1934338114239278,"antibodyCount":84,"monoclonalCount":6,"pubmedCount":null,"jensenScore":17.894784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.478229122730994,"pubTatorScore":1.7092121247073575,"self":"https://pharos.nih.gov/idg/api/v1/targets(15676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/publications"},"_namespace":null},{"id":15677,"version":3,"created":1554984411000,"modified":1555042850000,"deprecated":false,"name":"C-C motif chemokine 21","accession":"O00585","gene":"CCL21","description":"Inhibits hemopoiesis and stimulates chemotaxis. 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Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.880282340894505,"antibodyCount":381,"monoclonalCount":64,"pubmedCount":null,"jensenScore":733.503092,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":27.69825602946873,"pubTatorScore":2.4843699160069175,"self":"https://pharos.nih.gov/idg/api/v1/targets(15677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/publications"},"_namespace":null},{"id":15678,"version":3,"created":1554984415000,"modified":1555042851000,"deprecated":false,"name":"Ribonuclease T2","accession":"O00584","gene":"RNASET2","description":"Has ribonuclease activity, with higher activity at acidic pH. 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Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7884545602067234,"antibodyCount":35,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.635221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.785979118485653,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(15722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/publications"},"_namespace":null},{"id":15723,"version":2,"created":1554984917000,"modified":1554984921000,"deprecated":false,"name":"Whirlin","accession":"Q9P202","gene":"WHRN","description":"Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7495848774318001,"antibodyCount":123,"monoclonalCount":39,"pubmedCount":null,"jensenScore":54.088528,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.2162620964399613,"self":"https://pharos.nih.gov/idg/api/v1/targets(15723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/publications"},"_namespace":null},{"id":15724,"version":2,"created":1554984922000,"modified":1554984926000,"deprecated":false,"name":"BTB/POZ domain-containing protein 7","accession":"Q9P203","gene":"BTBD7","description":"Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1940516210018026,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.332593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.69632847195383,"pubTatorScore":0.9225524321562364,"self":"https://pharos.nih.gov/idg/api/v1/targets(15724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/publications"},"_namespace":null},{"id":15725,"version":3,"created":1554984926000,"modified":1555042875000,"deprecated":false,"name":"Mitotic-spindle organizing protein 1","accession":"Q08AG7","gene":"MZT1","description":"Required for gamma-tubulin complex recruitment to the centrosome.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8780154246376088,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.283595,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":28.057356350466545,"pubTatorScore":0.6989700043360189,"self":"https://pharos.nih.gov/idg/api/v1/targets(15725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/publications"},"_namespace":null},{"id":15726,"version":2,"created":1554984932000,"modified":1554984935000,"deprecated":false,"name":"Cytochrome b5 reductase 4","accession":"Q7L1T6","gene":"CYB5R4","description":"NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1555407183011783,"antibodyCount":107,"monoclonalCount":39,"pubmedCount":null,"jensenScore":17.526664,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.65807367642358,"pubTatorScore":0.7118072290411911,"self":"https://pharos.nih.gov/idg/api/v1/targets(15726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/publications"},"_namespace":null},{"id":15727,"version":2,"created":1554984936000,"modified":1554984940000,"deprecated":false,"name":"Uncharacterized protein KIAA1522","accession":"Q9P206","gene":"KIAA1522","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.21998348511502275,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.122409,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.660288145676052,"pubTatorScore":0.15103534228890542,"self":"https://pharos.nih.gov/idg/api/v1/targets(15727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/publications"},"_namespace":null},{"id":15728,"version":2,"created":1554984940000,"modified":1554984941000,"deprecated":false,"name":"Ribonuclease 8","accession":"Q8TDE3","gene":"RNASE8","description":"Has a low ribonuclease activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9030899869919435,"antibodyCount":60,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.013889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.693997386813589,"pubTatorScore":0.8016323233755616,"self":"https://pharos.nih.gov/idg/api/v1/targets(15728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/properties"},"_links":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/publications"},"_namespace":null},{"id":15729,"version":3,"created":1554984941000,"modified":1555042876000,"deprecated":false,"name":"Centrosomal protein of 72 kDa","accession":"Q9P209","gene":"CEP72","description":"Involved in the recruitment of key centrosomal proteins to the centrosome. 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Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7310512811400259,"antibodyCount":110,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.22109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":33.70859584300126,"pubTatorScore":0.6715050573872213,"self":"https://pharos.nih.gov/idg/api/v1/targets(15729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/publications"},"_namespace":null},{"id":15730,"version":2,"created":1554984946000,"modified":1554984947000,"deprecated":false,"name":"Uncharacterized protein C11orf71","accession":"Q6IPW1","gene":"C11orf71","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(15730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/properties"},"_links":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/publications"},"_namespace":null},{"id":15731,"version":3,"created":1554984947000,"modified":1555042878000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(k) subunit alpha","accession":"P08754","gene":"GNAI3","description":"Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4221940821988932,"antibodyCount":136,"monoclonalCount":5,"pubmedCount":null,"jensenScore":24.792931,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":48.17227342732339,"pubTatorScore":1.6195694676050696,"self":"https://pharos.nih.gov/idg/api/v1/targets(15731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/synonyms"},"_publications":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/publications"},"_namespace":null},{"id":15732,"version":2,"created":1554984954000,"modified":1554984956000,"deprecated":false,"name":"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3","accession":"P0C6S8","gene":"LINGO3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.1497623216000243,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.382857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.455464895919253,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(15732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/properties"},"_links":{"count":692,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/publications"},"_namespace":null},{"id":15733,"version":3,"created":1554984957000,"modified":1555042879000,"deprecated":false,"name":"Dedicator of cytokinesis protein 4","accession":"Q8N1I0","gene":"DOCK4","description":"Involved in regulation of adherens junction between cells. 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Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.657374037980198,"antibodyCount":101,"monoclonalCount":48,"pubmedCount":null,"jensenScore":45.823699,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.39158932378023,"pubTatorScore":1.5608638407476751,"self":"https://pharos.nih.gov/idg/api/v1/targets(15733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/publications"},"_namespace":null},{"id":15734,"version":3,"created":1554984963000,"modified":1555042881000,"deprecated":false,"name":"Delta-like protein 1","accession":"O00548","gene":"DLL1","description":"Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. 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Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8563260100778446,"antibodyCount":67,"monoclonalCount":22,"pubmedCount":null,"jensenScore":9.127792,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.548852375721484,"pubTatorScore":0.6154239528859439,"self":"https://pharos.nih.gov/idg/api/v1/targets(15799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/publications"},"_namespace":null},{"id":15800,"version":2,"created":1554985279000,"modified":1554985283000,"deprecated":false,"name":"Claudin-5","accession":"O00501","gene":"CLDN5","description":"Plays a major role in tight junction-specific obliteration of the intercellular space.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.589675005580801,"antibodyCount":300,"monoclonalCount":55,"pubmedCount":null,"jensenScore":349.394923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.95248940168712,"pubTatorScore":2.2587255571536,"self":"https://pharos.nih.gov/idg/api/v1/targets(15800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/publications"},"_namespace":null},{"id":15801,"version":3,"created":1554985284000,"modified":1555042916000,"deprecated":false,"name":"Neurotrophin receptor-interacting factor homolog","accession":"Q96GC6","gene":"ZNF274","description":"Probable transcription repressor. 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The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.440915843214341,"antibodyCount":194,"monoclonalCount":61,"pubmedCount":null,"jensenScore":23.10455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":38.47979249456351,"pubTatorScore":1.183111589269761,"self":"https://pharos.nih.gov/idg/api/v1/targets(15801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/publications"},"_namespace":null},{"id":15802,"version":3,"created":1554985289000,"modified":1555042919000,"deprecated":false,"name":"Fibroblast growth factor 8","accession":"P55075","gene":"FGF8","description":"Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7336812649261732,"antibodyCount":299,"monoclonalCount":95,"pubmedCount":null,"jensenScore":532.003896,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":95,"knowledgeAvailability":35.32691260182575,"pubTatorScore":2.3457720576270393,"self":"https://pharos.nih.gov/idg/api/v1/targets(15802)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/publications"},"_namespace":null},{"id":15803,"version":2,"created":1554985294000,"modified":1554985299000,"deprecated":false,"name":"Vacuole membrane protein 1","accession":"Q96GC9","gene":"VMP1","description":"Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. 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RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2198505322535715,"antibodyCount":199,"monoclonalCount":2,"pubmedCount":null,"jensenScore":98.029864,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.42857758314699,"pubTatorScore":2.257393089597244,"self":"https://pharos.nih.gov/idg/api/v1/targets(15804)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/publications"},"_namespace":null},{"id":15805,"version":4,"created":1554985304000,"modified":1555042920000,"deprecated":false,"name":"Transitional endoplasmic reticulum ATPase","accession":"P55072","gene":"VCP","description":"Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. 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Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). 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Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). 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Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1039132594941905,"antibodyCount":219,"monoclonalCount":71,"pubmedCount":null,"jensenScore":151.972489,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":43.60494078906448,"pubTatorScore":1.495314850111537,"self":"https://pharos.nih.gov/idg/api/v1/targets(15903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/properties"},"_links":{"count":1121,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/publications"},"_namespace":null},{"id":15904,"version":3,"created":1554986545000,"modified":1555042989000,"deprecated":false,"name":"RalA-binding protein 1","accession":"Q15311","gene":"RALBP1","description":"Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.996667448512697,"antibodyCount":320,"monoclonalCount":105,"pubmedCount":null,"jensenScore":110.826682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":47.893626378649955,"pubTatorScore":1.966622659948005,"self":"https://pharos.nih.gov/idg/api/v1/targets(15904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/publications"},"_namespace":null},{"id":15905,"version":3,"created":1554986551000,"modified":1555042991000,"deprecated":false,"name":"Growth/differentiation factor 5","accession":"P43026","gene":"GDF5","description":"Growth factor involved in bone and cartilage formation. 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Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.919874828082859,"antibodyCount":226,"monoclonalCount":43,"pubmedCount":null,"jensenScore":81.576667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":24.89233969756694,"pubTatorScore":1.8690385918168646,"self":"https://pharos.nih.gov/idg/api/v1/targets(15907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/publications"},"_namespace":null},{"id":15908,"version":3,"created":1554986569000,"modified":1555042994000,"deprecated":false,"name":"Nuclear factor interleukin-3-regulated protein","accession":"Q16649","gene":"NFIL3","description":"Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9160282229678731,"antibodyCount":265,"monoclonalCount":46,"pubmedCount":null,"jensenScore":90.668346,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.529929096818876,"pubTatorScore":1.591086900237716,"self":"https://pharos.nih.gov/idg/api/v1/targets(15908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/publications"},"_namespace":null},{"id":15909,"version":2,"created":1554986574000,"modified":1554986578000,"deprecated":false,"name":"6.8 kDa mitochondrial proteolipid","accession":"P56378","gene":"ATP5MPL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8383992782859753,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.73869,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(15909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/publications"},"_namespace":null},{"id":15910,"version":3,"created":1554986579000,"modified":1555042996000,"deprecated":false,"name":"MAP kinase-activated protein kinase 3","accession":"Q16644","gene":"MAPKAPK3","description":"Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. 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Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. 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Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.4792414356877672,"antibodyCount":1450,"monoclonalCount":615,"pubmedCount":null,"jensenScore":3234.037708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":60.3028480435792,"pubTatorScore":3.708909405117298,"self":"https://pharos.nih.gov/idg/api/v1/targets(15978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":3106,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/properties"},"_links":{"count":3648,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/links"},"_synonyms":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/synonyms"},"_publications":{"count":2565,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/publications"},"_namespace":null},{"id":15979,"version":2,"created":1554987190000,"modified":1554987195000,"deprecated":false,"name":"Protocadherin-10","accession":"Q9P2E7","gene":"PCDH10","description":"Potential calcium-dependent cell-adhesion protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7559045537445526,"antibodyCount":104,"monoclonalCount":28,"pubmedCount":null,"jensenScore":63.804889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.34771763034161,"pubTatorScore":1.6930397543031135,"self":"https://pharos.nih.gov/idg/api/v1/targets(15979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/publications"},"_namespace":null},{"id":15980,"version":2,"created":1554987196000,"modified":1554987208000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily C member 3","accession":"Q14003","gene":"KCNC3","description":"Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.7754097085585814,"antibodyCount":232,"monoclonalCount":45,"pubmedCount":null,"jensenScore":61.876747,"patentCount":2281,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.25472864733887,"pubTatorScore":1.6123440857507347,"self":"https://pharos.nih.gov/idg/api/v1/targets(15980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/publications"},"_namespace":null},{"id":15981,"version":2,"created":1554987209000,"modified":1554987214000,"deprecated":false,"name":"Bax inhibitor 1","accession":"P55061","gene":"TMBIM6","description":"Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.475153587691762,"antibodyCount":151,"monoclonalCount":122,"pubmedCount":null,"jensenScore":305.327869,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.54949456068722,"pubTatorScore":2.0550569071809344,"self":"https://pharos.nih.gov/idg/api/v1/targets(15981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/publications"},"_namespace":null},{"id":15982,"version":2,"created":1554987215000,"modified":1554987228000,"deprecated":false,"name":"Excitatory amino acid transporter 1","accession":"P43003","gene":"SLC1A3","description":"Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.7640172965181606,"antibodyCount":221,"monoclonalCount":28,"pubmedCount":null,"jensenScore":569.663356,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.51655606279393,"pubTatorScore":2.3940508382256214,"self":"https://pharos.nih.gov/idg/api/v1/targets(15982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/properties"},"_links":{"count":1046,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/publications"},"_namespace":null},{"id":15983,"version":2,"created":1554987229000,"modified":1554987233000,"deprecated":false,"name":"Lethal(2) giant larvae protein homolog 1","accession":"Q15334","gene":"LLGL1","description":"Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0920085342087247,"antibodyCount":143,"monoclonalCount":9,"pubmedCount":null,"jensenScore":1212.432042,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.747715167543205,"pubTatorScore":1.3963653937446907,"self":"https://pharos.nih.gov/idg/api/v1/targets(15983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/publications"},"_namespace":null},{"id":15984,"version":3,"created":1554987234000,"modified":1555043046000,"deprecated":false,"name":"ER membrane protein complex subunit 4","accession":"Q5J8M3","gene":"EMC4","description":"May mediate anti-apoptotic activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5854607290742062,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.947223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":26.31441763156565,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(15984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/publications"},"_namespace":null},{"id":15985,"version":2,"created":1554987239000,"modified":1554987242000,"deprecated":false,"name":"Carcinoembryonic antigen-related cell adhesion molecule 7","accession":"Q14002","gene":"CEACAM7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1199531567791627,"antibodyCount":151,"monoclonalCount":31,"pubmedCount":null,"jensenScore":15.243118,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.86172355285111,"pubTatorScore":1.2687985730098956,"self":"https://pharos.nih.gov/idg/api/v1/targets(15985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/properties"},"_links":{"count":550,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/publications"},"_namespace":null},{"id":15986,"version":2,"created":1554987243000,"modified":1554987247000,"deprecated":false,"name":"E3 ubiquitin-protein ligase MARCH4","accession":"Q9P2E8","gene":"MARCH4","description":"E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2436141965941652,"antibodyCount":149,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.935714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.35578233468354,"pubTatorScore":2.177151570452557,"self":"https://pharos.nih.gov/idg/api/v1/targets(15986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/publications"},"_namespace":null},{"id":15987,"version":2,"created":1554987248000,"modified":1554987252000,"deprecated":false,"name":"Exportin-2","accession":"P55060","gene":"CSE1L","description":"Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9877095714567803,"antibodyCount":408,"monoclonalCount":213,"pubmedCount":null,"jensenScore":99.194053,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.31134352228251,"pubTatorScore":2.1140365819838856,"self":"https://pharos.nih.gov/idg/api/v1/targets(15987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/publications"},"_namespace":null},{"id":15988,"version":2,"created":1554987253000,"modified":1554987264000,"deprecated":false,"name":"Excitatory amino acid transporter 2","accession":"P43004","gene":"SLC1A2","description":"Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.962366365105924,"antibodyCount":187,"monoclonalCount":87,"pubmedCount":null,"jensenScore":939.639454,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.49533193887202,"pubTatorScore":2.609021220193143,"self":"https://pharos.nih.gov/idg/api/v1/targets(15988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/publications"},"_namespace":null},{"id":15989,"version":3,"created":1554987266000,"modified":1555043048000,"deprecated":false,"name":"Excitatory amino acid transporter 3","accession":"P43005","gene":"SLC1A1","description":"Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.5965980510753712,"antibodyCount":251,"monoclonalCount":104,"pubmedCount":null,"jensenScore":395.602392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":45.73666298096971,"pubTatorScore":2.3704303178030326,"self":"https://pharos.nih.gov/idg/api/v1/targets(15989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/synonyms"},"_publications":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/publications"},"_namespace":null},{"id":15990,"version":2,"created":1554987276000,"modified":1554987285000,"deprecated":false,"name":"Ribosome-binding protein 1","accession":"Q9P2E9","gene":"RRBP1","description":"Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.645302012486473,"antibodyCount":157,"monoclonalCount":22,"pubmedCount":null,"jensenScore":433.273213,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.91107608036585,"pubTatorScore":1.4372407760787191,"self":"https://pharos.nih.gov/idg/api/v1/targets(15990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/properties"},"_links":{"count":1188,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/publications"},"_namespace":null},{"id":15991,"version":2,"created":1554987286000,"modified":1554987287000,"deprecated":false,"name":"Guanylate cyclase activator 2B","accession":"Q16661","gene":"GUCA2B","description":"Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. 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After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. 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May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.658387441287998,"antibodyCount":397,"monoclonalCount":79,"pubmedCount":null,"jensenScore":4688.024194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.755561132442786,"pubTatorScore":3.6597974554239783,"self":"https://pharos.nih.gov/idg/api/v1/targets(16126)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(16126)/properties"},"_links":{"count":1396,"href":"https://pharos.nih.gov/idg/api/v1/targets(16126)/links"},"_synonyms":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(16126)/synonyms"},"_publications":{"count":768,"href":"https://pharos.nih.gov/idg/api/v1/targets(16126)/publications"},"_namespace":null},{"id":16127,"version":2,"created":1554988373000,"modified":1554988374000,"deprecated":false,"name":"Late cornified envelope protein 3E","accession":"Q5T5B0","gene":"LCE3E","description":"Precursors of the cornified envelope of the stratum corneum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7182801222427426,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.152883,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.281142137680265,"pubTatorScore":-0.8430240325152318,"self":"https://pharos.nih.gov/idg/api/v1/targets(16127)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(16127)/properties"},"_links":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(16127)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(16127)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16127)/publications"},"_namespace":null},{"id":16128,"version":2,"created":1554988374000,"modified":1554988378000,"deprecated":false,"name":"AT-rich interactive domain-containing protein 4B","accession":"Q4LE39","gene":"ARID4B","description":"Acts as a transcriptional repressor. 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It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. 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It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6828960950249705,"antibodyCount":598,"monoclonalCount":98,"pubmedCount":null,"jensenScore":825.41979,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":50.16919957346831,"pubTatorScore":2.9183921044290435,"self":"https://pharos.nih.gov/idg/api/v1/targets(16135)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(16135)/properties"},"_links":{"count":1565,"href":"https://pharos.nih.gov/idg/api/v1/targets(16135)/links"},"_synonyms":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(16135)/synonyms"},"_publications":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(16135)/publications"},"_namespace":null},{"id":16136,"version":3,"created":1554988417000,"modified":1555043133000,"deprecated":false,"name":"Complement component C8 beta chain","accession":"P07358","gene":"C8B","description":"Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5712265498833384,"antibodyCount":104,"monoclonalCount":8,"pubmedCount":null,"jensenScore":37.003759,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":24.149854759926114,"pubTatorScore":2.11222318070894,"self":"https://pharos.nih.gov/idg/api/v1/targets(16136)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(16136)/properties"},"_links":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(16136)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(16136)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(16136)/publications"},"_namespace":null},{"id":16137,"version":2,"created":1554988421000,"modified":1554988425000,"deprecated":false,"name":"Steroid 21-hydroxylase","accession":"P08686","gene":"CYP21A2","description":"Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids (PubMed:22014889).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":214,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.19090351111557,"pubTatorScore":3.015779900546188,"self":"https://pharos.nih.gov/idg/api/v1/targets(16137)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":545,"href":"https://pharos.nih.gov/idg/api/v1/targets(16137)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(16137)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(16137)/synonyms"},"_publications":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(16137)/publications"},"_namespace":null},{"id":16138,"version":3,"created":1554988426000,"modified":1555043134000,"deprecated":false,"name":"Complement component C8 alpha chain","accession":"P07357","gene":"C8A","description":"Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7211835451838418,"antibodyCount":10,"monoclonalCount":2,"pubmedCount":null,"jensenScore":49.796887,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":29.185334667857386,"pubTatorScore":1.8322072031855974,"self":"https://pharos.nih.gov/idg/api/v1/targets(16138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(16138)/properties"},"_links":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(16138)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(16138)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(16138)/publications"},"_namespace":null},{"id":16139,"version":3,"created":1554988429000,"modified":1555043136000,"deprecated":false,"name":"Glycophorin-B","accession":"P06028","gene":"GYPB","description":"This protein is a minor sialoglycoprotein in erythrocyte membranes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.565340095259776,"antibodyCount":85,"monoclonalCount":4,"pubmedCount":null,"jensenScore":377.269471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":47,"knowledgeAvailability":14.301654976492603,"pubTatorScore":1.4445651999594131,"self":"https://pharos.nih.gov/idg/api/v1/targets(16139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(16139)/properties"},"_links":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(16139)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(16139)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(16139)/publications"},"_namespace":null},{"id":16140,"version":3,"created":1554988431000,"modified":1555043136000,"deprecated":false,"name":"Platelet glycoprotein Ib alpha chain","accession":"P07359","gene":"GP1BA","description":"GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.809811222237756,"antibodyCount":623,"monoclonalCount":463,"pubmedCount":null,"jensenScore":615.6413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.76018509596298,"pubTatorScore":2.784220465035427,"self":"https://pharos.nih.gov/idg/api/v1/targets(16140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":612,"href":"https://pharos.nih.gov/idg/api/v1/targets(16140)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(16140)/links"},"_synonyms":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(16140)/synonyms"},"_publications":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(16140)/publications"},"_namespace":null},{"id":16141,"version":2,"created":1554988438000,"modified":1554988441000,"deprecated":false,"name":"Cortexin-3","accession":"Q4LDR2","gene":"CTXN3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2453838300165911,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.326277,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.259986657926632,"pubTatorScore":0.9651689042021067,"self":"https://pharos.nih.gov/idg/api/v1/targets(16141)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(16141)/properties"},"_links":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(16141)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(16141)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16141)/publications"},"_namespace":null},{"id":16142,"version":2,"created":1554988441000,"modified":1554988445000,"deprecated":false,"name":"Calmodulin-regulated spectrin-associated protein 3","accession":"Q9P1Y5","gene":"CAMSAP3","description":"Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). 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Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1269547130194604,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.091962,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.071195168138843,"pubTatorScore":0.8792869958590159,"self":"https://pharos.nih.gov/idg/api/v1/targets(16142)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(16142)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(16142)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(16142)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(16142)/publications"},"_namespace":null},{"id":16143,"version":3,"created":1554988446000,"modified":1555043138000,"deprecated":false,"name":"TBC1 domain family member 28","accession":"Q2M2D7","gene":"TBC1D28","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":65,"monoclonalCount":5,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":7.828090633005035,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(16143)/properties"},"_links":{"count":483,"href":"https://pharos.nih.gov/idg/api/v1/targets(16143)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(16143)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16143)/publications"},"_namespace":null},{"id":16144,"version":2,"created":1554988448000,"modified":1554988451000,"deprecated":false,"name":"PHD and RING finger domain-containing protein 1","accession":"Q9P1Y6","gene":"PHRF1","description":null,"idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.6072634873038731,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":29.079984,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.638191522113075,"pubTatorScore":0.5163149316871367,"self":"https://pharos.nih.gov/idg/api/v1/targets(16144)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(16144)/properties"},"_links":{"count":840,"href":"https://pharos.nih.gov/idg/api/v1/targets(16144)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(16144)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(16144)/publications"},"_namespace":null},{"id":16145,"version":3,"created":1554988451000,"modified":1555043139000,"deprecated":false,"name":"Nucleolin","accession":"P19338","gene":"NCL","description":"Nucleolin is the major nucleolar protein of growing eukaryotic cells. 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Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.843366057465603,"antibodyCount":487,"monoclonalCount":209,"pubmedCount":null,"jensenScore":683.314737,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":51.5059341244876,"pubTatorScore":3.0071452937536156,"self":"https://pharos.nih.gov/idg/api/v1/targets(16145)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":664,"href":"https://pharos.nih.gov/idg/api/v1/targets(16145)/properties"},"_links":{"count":1363,"href":"https://pharos.nih.gov/idg/api/v1/targets(16145)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16145)/synonyms"},"_publications":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(16145)/publications"},"_namespace":null},{"id":16146,"version":2,"created":1554988458000,"modified":1554988464000,"deprecated":false,"name":"E3 ubiquitin-protein ligase NEDD4","accession":"P46934","gene":"NEDD4","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 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Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.4404608262522367,"antibodyCount":167,"monoclonalCount":6,"pubmedCount":null,"jensenScore":259.824577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.031158154350784,"pubTatorScore":2.288921700094846,"self":"https://pharos.nih.gov/idg/api/v1/targets(16146)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":628,"href":"https://pharos.nih.gov/idg/api/v1/targets(16146)/properties"},"_links":{"count":1208,"href":"https://pharos.nih.gov/idg/api/v1/targets(16146)/links"},"_synonyms":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(16146)/synonyms"},"_publications":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(16146)/publications"},"_namespace":null},{"id":16147,"version":3,"created":1554988465000,"modified":1555043141000,"deprecated":false,"name":"Transcriptional coactivator YAP1","accession":"P46937","gene":"YAP1","description":"Isoform 2: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6227374720536636,"antibodyCount":581,"monoclonalCount":170,"pubmedCount":null,"jensenScore":411.721415,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":51.427988698652655,"pubTatorScore":2.850383365829839,"self":"https://pharos.nih.gov/idg/api/v1/targets(16147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(16147)/properties"},"_links":{"count":1562,"href":"https://pharos.nih.gov/idg/api/v1/targets(16147)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(16147)/synonyms"},"_publications":{"count":515,"href":"https://pharos.nih.gov/idg/api/v1/targets(16147)/publications"},"_namespace":null},{"id":16148,"version":2,"created":1554988476000,"modified":1554988477000,"deprecated":false,"name":"Coiled-coil domain-containing protein 169","accession":"A6NNP5","gene":"CCDC169","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.764711326775863,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(16148)/properties"},"_links":{"count":755,"href":"https://pharos.nih.gov/idg/api/v1/targets(16148)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(16148)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(16148)/publications"},"_namespace":null},{"id":16149,"version":2,"created":1554988478000,"modified":1554988484000,"deprecated":false,"name":"Utrophin","accession":"P46939","gene":"UTRN","description":"May play a role in anchoring the cytoskeleton to the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6365798288529647,"antibodyCount":37,"monoclonalCount":9,"pubmedCount":null,"jensenScore":425.046101,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.851079046444724,"pubTatorScore":2.245879711119438,"self":"https://pharos.nih.gov/idg/api/v1/targets(16149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":495,"href":"https://pharos.nih.gov/idg/api/v1/targets(16149)/properties"},"_links":{"count":1194,"href":"https://pharos.nih.gov/idg/api/v1/targets(16149)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(16149)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16149)/publications"},"_namespace":null},{"id":16150,"version":2,"created":1554988486000,"modified":1554988489000,"deprecated":false,"name":"Protein GAPT","accession":"Q8N292","gene":"GAPT","description":"Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. 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These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9481177042303588,"antibodyCount":191,"monoclonalCount":40,"pubmedCount":null,"jensenScore":86.526476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":36.321842301595964,"pubTatorScore":1.3533070033055268,"self":"https://pharos.nih.gov/idg/api/v1/targets(16178)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(16178)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(16178)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(16178)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(16178)/publications"},"_namespace":null},{"id":16179,"version":2,"created":1554988619000,"modified":1554988623000,"deprecated":false,"name":"Zinc finger protein 710","accession":"Q8N1W2","gene":"ZNF710","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.071429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.557341488324113,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16179)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(16179)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(16179)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(16179)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16179)/publications"},"_namespace":null},{"id":16180,"version":3,"created":1554988623000,"modified":1555043166000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1","accession":"Q96GM5","gene":"SMARCD1","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2863866621722428,"antibodyCount":184,"monoclonalCount":5,"pubmedCount":null,"jensenScore":17.492611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":37.46007781737128,"pubTatorScore":1.0476765305689006,"self":"https://pharos.nih.gov/idg/api/v1/targets(16180)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":422,"href":"https://pharos.nih.gov/idg/api/v1/targets(16180)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(16180)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16180)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(16180)/publications"},"_namespace":null},{"id":16181,"version":2,"created":1554988628000,"modified":1554988633000,"deprecated":false,"name":"Uncharacterized protein KIAA0513","accession":"O60268","gene":"KIAA0513","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.05836812352451519,"antibodyCount":66,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.188096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.78242834328054,"pubTatorScore":-0.12264708611740738,"self":"https://pharos.nih.gov/idg/api/v1/targets(16181)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(16181)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(16181)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(16181)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(16181)/publications"},"_namespace":null},{"id":16182,"version":2,"created":1554988634000,"modified":1554988639000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 28","accession":"Q8N1W1","gene":"ARHGEF28","description":"Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6250629509766699,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":29.740692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.379540717562676,"pubTatorScore":1.1202061386537432,"self":"https://pharos.nih.gov/idg/api/v1/targets(16182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(16182)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(16182)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(16182)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(16182)/publications"},"_namespace":null},{"id":16183,"version":2,"created":1554988640000,"modified":1554988641000,"deprecated":false,"name":"Immunoglobulin kappa variable 3D-20","accession":"A0A0C4DH25","gene":"IGKV3D-20","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.494799757794877,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(16183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(16183)/properties"},"_links":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(16183)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(16183)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(16183)/publications"},"_namespace":null},{"id":16184,"version":2,"created":1554988641000,"modified":1554988642000,"deprecated":false,"name":"Immunoglobulin kappa variable 6-21","accession":"A0A0C4DH24","gene":"IGKV6-21","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.820913759573187,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/properties"},"_links":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/publications"},"_namespace":null},{"id":16185,"version":2,"created":1554988642000,"modified":1554988645000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 35","accession":"Q8N283","gene":"ANKRD35","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.370570291139817,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(16185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/publications"},"_namespace":null},{"id":16186,"version":2,"created":1554988646000,"modified":1554988652000,"deprecated":false,"name":"DmX-like protein 2","accession":"Q8TDJ6","gene":"DMXL2","description":"May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9278345792238878,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.339632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.836610066278794,"pubTatorScore":0.7235302099464002,"self":"https://pharos.nih.gov/idg/api/v1/targets(16186)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/publications"},"_namespace":null},{"id":16187,"version":2,"created":1554988653000,"modified":1554988658000,"deprecated":false,"name":"Adenylate cyclase type 3","accession":"O60266","gene":"ADCY3","description":"Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.315926106131338,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":204.354385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.421213182906875,"pubTatorScore":1.83863038414088,"self":"https://pharos.nih.gov/idg/api/v1/targets(16187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":540,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/publications"},"_namespace":null},{"id":16188,"version":3,"created":1554988659000,"modified":1555043168000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5","accession":"O60264","gene":"SMARCA5","description":"Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1272052883612718,"antibodyCount":299,"monoclonalCount":67,"pubmedCount":null,"jensenScore":128.43087,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":48.166223340915515,"pubTatorScore":1.8372589754212278,"self":"https://pharos.nih.gov/idg/api/v1/targets(16188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/properties"},"_links":{"count":1224,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/publications"},"_namespace":null},{"id":16189,"version":2,"created":1554988667000,"modified":1554988667000,"deprecated":false,"name":"Immunoglobulin heavy variable 1-3","accession":"A0A0C4DH29","gene":"IGHV1-3","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.6567693374641719,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/properties"},"_links":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/publications"},"_namespace":null},{"id":16190,"version":2,"created":1554988668000,"modified":1554988672000,"deprecated":false,"name":"Tyrosine-protein kinase Fes/Fps","accession":"P07332","gene":"FES","description":"Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.050375830257087,"antibodyCount":314,"monoclonalCount":82,"pubmedCount":null,"jensenScore":1109.248117,"patentCount":46744,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.97667468280165,"pubTatorScore":1.6036855387979005,"self":"https://pharos.nih.gov/idg/api/v1/targets(16190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/properties"},"_links":{"count":1173,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/publications"},"_namespace":null},{"id":16191,"version":2,"created":1554988674000,"modified":1554988678000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7","accession":"O60262","gene":"GNG7","description":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7625952181066346,"antibodyCount":63,"monoclonalCount":13,"pubmedCount":null,"jensenScore":5.384426,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.76859876292907,"pubTatorScore":0.7096937849873969,"self":"https://pharos.nih.gov/idg/api/v1/targets(16191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/publications"},"_namespace":null},{"id":16192,"version":3,"created":1554988679000,"modified":1555043170000,"deprecated":false,"name":"E3 ubiquitin-protein ligase parkin","accession":"O60260","gene":"PRKN","description":"Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11590439, PubMed:11431533, PubMed:19229105, PubMed:11590439, PubMed:15728840). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy (PubMed:25621951). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death (PubMed:21376232). Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.9961820114461433,"antibodyCount":533,"monoclonalCount":58,"pubmedCount":null,"jensenScore":1004.071903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":0.0,"pubTatorScore":2.7540931540366342,"self":"https://pharos.nih.gov/idg/api/v1/targets(16192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1121,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/properties"},"_links":{"count":1527,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/links"},"_synonyms":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/synonyms"},"_publications":{"count":639,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/publications"},"_namespace":null},{"id":16193,"version":3,"created":1554988691000,"modified":1554988806000,"deprecated":false,"name":"Macrophage colony-stimulating factor 1 receptor","accession":"P07333","gene":"CSF1R","description":"Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.1910871586653395,"antibodyCount":1169,"monoclonalCount":379,"pubmedCount":null,"jensenScore":1432.860331,"patentCount":108131,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.45656650460444,"pubTatorScore":2.7423286609942163,"self":"https://pharos.nih.gov/idg/api/v1/targets(16193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/properties"},"_links":{"count":1572,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/synonyms"},"_publications":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/publications"},"_namespace":null},{"id":16194,"version":3,"created":1554988809000,"modified":1554988973000,"deprecated":false,"name":"Cathepsin D","accession":"P07339","gene":"CTSD","description":"Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.470608148623589,"antibodyCount":779,"monoclonalCount":244,"pubmedCount":null,"jensenScore":2866.765427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.567068488215945,"pubTatorScore":3.256582776773943,"self":"https://pharos.nih.gov/idg/api/v1/targets(16194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":717,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/properties"},"_links":{"count":1999,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/synonyms"},"_publications":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/publications"},"_namespace":null},{"id":16195,"version":3,"created":1554988976000,"modified":1555043173000,"deprecated":false,"name":"ERI1 exoribonuclease 2","accession":"A8K979","gene":"ERI2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.690196085674342,"antibodyCount":93,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.190507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.66667685907862,"pubTatorScore":0.42324587393680785,"self":"https://pharos.nih.gov/idg/api/v1/targets(16195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/properties"},"_links":{"count":822,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/publications"},"_namespace":null},{"id":16196,"version":2,"created":1554988981000,"modified":1554988981000,"deprecated":false,"name":"Putative inactive cathepsin L-like protein CTSL3P","accession":"Q5NE16","gene":"CTSL3P","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.765452476132514,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/publications"},"_namespace":null},{"id":16197,"version":3,"created":1554988981000,"modified":1555043174000,"deprecated":false,"name":"Phospholipid phosphatase-related protein type 2","accession":"Q96GM1","gene":"PLPPR2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.581818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":0.0,"pubTatorScore":-0.3521829524060615,"self":"https://pharos.nih.gov/idg/api/v1/targets(16197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/publications"},"_namespace":null},{"id":16198,"version":2,"created":1554988984000,"modified":1554988993000,"deprecated":false,"name":"Keratin, type I cytoskeletal 17","accession":"Q04695","gene":"KRT17","description":"Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial \"stem cells\". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4390931379312804,"antibodyCount":711,"monoclonalCount":361,"pubmedCount":null,"jensenScore":265.841808,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.98857871116356,"pubTatorScore":2.415362191456079,"self":"https://pharos.nih.gov/idg/api/v1/targets(16198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/properties"},"_links":{"count":1068,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/publications"},"_namespace":null},{"id":16199,"version":3,"created":1554988995000,"modified":1555043176000,"deprecated":false,"name":"Vascular cell adhesion protein 1","accession":"P19320","gene":"VCAM1","description":"Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.5504444683229726,"antibodyCount":1291,"monoclonalCount":891,"pubmedCount":null,"jensenScore":3444.105101,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":42.52378149216253,"pubTatorScore":3.3416990565586393,"self":"https://pharos.nih.gov/idg/api/v1/targets(16199)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(16199)/properties"},"_links":{"count":1580,"href":"https://pharos.nih.gov/idg/api/v1/targets(16199)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(16199)/synonyms"},"_publications":{"count":495,"href":"https://pharos.nih.gov/idg/api/v1/targets(16199)/publications"},"_namespace":null},{"id":16200,"version":3,"created":1554989006000,"modified":1555043179000,"deprecated":false,"name":"WD repeat-containing protein 27","accession":"A2RRH5","gene":"WDR27","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2022952119835092,"antibodyCount":75,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.556566,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.618609508335325,"pubTatorScore":-0.48746234968114194,"self":"https://pharos.nih.gov/idg/api/v1/targets(16200)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(16200)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(16200)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(16200)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(16200)/publications"},"_namespace":null},{"id":16201,"version":2,"created":1554989010000,"modified":1554989014000,"deprecated":false,"name":"Heat shock 70 kDa protein 1-like","accession":"P34931","gene":"HSPA1L","description":"Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6042030412981318,"antibodyCount":242,"monoclonalCount":73,"pubmedCount":null,"jensenScore":38.864726,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.830942220054766,"pubTatorScore":1.6547194749078993,"self":"https://pharos.nih.gov/idg/api/v1/targets(16201)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(16201)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(16201)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(16201)/synonyms"},"_publications":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(16201)/publications"},"_namespace":null},{"id":16202,"version":2,"created":1554989015000,"modified":1554989022000,"deprecated":false,"name":"Heat shock 70 kDa protein 4","accession":"P34932","gene":"HSPA4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.926721664364165,"antibodyCount":432,"monoclonalCount":159,"pubmedCount":null,"jensenScore":8635.128163,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.34300966680639,"pubTatorScore":3.5438243527953994,"self":"https://pharos.nih.gov/idg/api/v1/targets(16202)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":604,"href":"https://pharos.nih.gov/idg/api/v1/targets(16202)/properties"},"_links":{"count":1398,"href":"https://pharos.nih.gov/idg/api/v1/targets(16202)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16202)/synonyms"},"_publications":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(16202)/publications"},"_namespace":null},{"id":16203,"version":2,"created":1554989024000,"modified":1554989027000,"deprecated":false,"name":"Transmembrane channel-like protein 2","accession":"Q8TDI7","gene":"TMC2","description":"Probable ion channel required for the normal function of cochlear hair cells (PubMed:11850618). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).","idgFamily":"Ion 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Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.644916454602587,"antibodyCount":546,"monoclonalCount":313,"pubmedCount":null,"jensenScore":489.625849,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":64,"knowledgeAvailability":26.262544195012186,"pubTatorScore":2.404913513464373,"self":"https://pharos.nih.gov/idg/api/v1/targets(16215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/synonyms"},"_publications":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/publications"},"_namespace":null},{"id":16216,"version":2,"created":1554989373000,"modified":1554989377000,"deprecated":false,"name":"CMRF35-like molecule 1","accession":"Q8TDQ1","gene":"CD300LF","description":"Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5816067209276758,"antibodyCount":183,"monoclonalCount":52,"pubmedCount":null,"jensenScore":43.395692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.11905265795739,"pubTatorScore":1.281943703289339,"self":"https://pharos.nih.gov/idg/api/v1/targets(16216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/publications"},"_namespace":null},{"id":16217,"version":2,"created":1554989378000,"modified":1554989381000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 18 homolog","accession":"Q9P253","gene":"VPS18","description":"Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9250472239873722,"antibodyCount":117,"monoclonalCount":69,"pubmedCount":null,"jensenScore":80.913408,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.460545448013086,"pubTatorScore":1.335481751126337,"self":"https://pharos.nih.gov/idg/api/v1/targets(16217)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/publications"},"_namespace":null},{"id":16218,"version":2,"created":1554989382000,"modified":1554989384000,"deprecated":false,"name":"Keratin-associated protein 5-1","accession":"Q6L8H4","gene":"KRTAP5-1","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. 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Seems to be the major component in this process (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5545569358602478,"antibodyCount":196,"monoclonalCount":26,"pubmedCount":null,"jensenScore":33.941469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":34,"knowledgeAvailability":42.518452769230166,"pubTatorScore":1.380333261318069,"self":"https://pharos.nih.gov/idg/api/v1/targets(16255)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(16255)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(16255)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(16255)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(16255)/publications"},"_namespace":null},{"id":16256,"version":3,"created":1554989544000,"modified":1555043203000,"deprecated":false,"name":"Methyl-CpG-binding domain protein 5","accession":"Q9P267","gene":"MBD5","description":"Binds to heterochromatin. 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Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. 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Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8249769704012875,"antibodyCount":175,"monoclonalCount":2,"pubmedCount":null,"jensenScore":65.955013,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.482109236586027,"pubTatorScore":1.6085647546594692,"self":"https://pharos.nih.gov/idg/api/v1/targets(16258)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(16258)/properties"},"_links":{"count":565,"href":"https://pharos.nih.gov/idg/api/v1/targets(16258)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(16258)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(16258)/publications"},"_namespace":null},{"id":16259,"version":4,"created":1554989557000,"modified":1555043205000,"deprecated":false,"name":"Corticotropin-releasing factor receptor 1","accession":"P34998","gene":"CRHR1","description":"G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. 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Implicated the smooth muscle contractile response to PGE2 in various tissues.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.644814847087414,"antibodyCount":168,"monoclonalCount":2,"pubmedCount":null,"jensenScore":401.975542,"patentCount":33999,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.399546164577924,"pubTatorScore":2.2968809941533808,"self":"https://pharos.nih.gov/idg/api/v1/targets(16261)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(16261)/properties"},"_links":{"count":1190,"href":"https://pharos.nih.gov/idg/api/v1/targets(16261)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(16261)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16261)/publications"},"_namespace":null},{"id":16262,"version":3,"created":1554990178000,"modified":1555043210000,"deprecated":false,"name":"BLOC-1-related complex subunit 6","accession":"Q96GS4","gene":"BORCS6","description":"As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.494799757794877,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(16263)/properties"},"_links":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(16263)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(16263)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(16263)/publications"},"_namespace":null},{"id":16264,"version":2,"created":1554990181000,"modified":1554990183000,"deprecated":false,"name":"Immunoglobulin heavy variable 3-20","accession":"A0A0C4DH32","gene":"IGHV3-20","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.069756278281265,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/properties"},"_links":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/publications"},"_namespace":null},{"id":16265,"version":3,"created":1554990183000,"modified":1555043212000,"deprecated":false,"name":"Fibroblast growth factor 17","accession":"O60258","gene":"FGF17","description":"Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6091067354781805,"antibodyCount":184,"monoclonalCount":32,"pubmedCount":null,"jensenScore":38.267056,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":40,"knowledgeAvailability":32.67062056620048,"pubTatorScore":1.0402996524363486,"self":"https://pharos.nih.gov/idg/api/v1/targets(16265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(16265)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(16265)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(16265)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(16265)/publications"},"_namespace":null},{"id":16266,"version":2,"created":1554990187000,"modified":1554990188000,"deprecated":false,"name":"Immunoglobulin heavy variable 1-18","accession":"A0A0C4DH31","gene":"IGHV1-18","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2815833687656488,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/properties"},"_links":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/publications"},"_namespace":null},{"id":16267,"version":3,"created":1554990188000,"modified":1555043213000,"deprecated":false,"name":"Kallikrein-8","accession":"O60259","gene":"KLK8","description":"Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. 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Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. 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Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8875637224721943,"antibodyCount":80,"monoclonalCount":19,"pubmedCount":null,"jensenScore":6.96827,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.5944198767325,"pubTatorScore":0.7465567506327095,"self":"https://pharos.nih.gov/idg/api/v1/targets(16346)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/publications"},"_namespace":null},{"id":16347,"version":3,"created":1554991484000,"modified":1555043270000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily V member 2","accession":"Q8TDN2","gene":"KCNV2","description":"Potassium channel subunit. 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Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7155322680976963,"antibodyCount":60,"monoclonalCount":19,"pubmedCount":null,"jensenScore":56.205963,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.63731788634075,"pubTatorScore":1.8468193504118877,"self":"https://pharos.nih.gov/idg/api/v1/targets(16353)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/publications"},"_namespace":null},{"id":16354,"version":3,"created":1554991525000,"modified":1555043276000,"deprecated":false,"name":"Histone H2A-Bbd type 1","accession":"P0C5Y9","gene":"H2AFB1","description":"Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). 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They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9493900088163852,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.00875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":12.336503288548355,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(16354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/properties"},"_links":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/publications"},"_namespace":null},{"id":16355,"version":2,"created":1554991526000,"modified":1554991538000,"deprecated":false,"name":"Transmembrane protease serine 11D","accession":"O60235","gene":"TMPRSS11D","description":"May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3008346071062538,"antibodyCount":97,"monoclonalCount":6,"pubmedCount":null,"jensenScore":201.832324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.414500262956416,"pubTatorScore":1.632119696983063,"self":"https://pharos.nih.gov/idg/api/v1/targets(16355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/properties"},"_links":{"count":648,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/publications"},"_namespace":null},{"id":16356,"version":3,"created":1554991539000,"modified":1555043278000,"deprecated":false,"name":"Sjoegren syndrome/scleroderma autoantigen 1","accession":"O60232","gene":"SSSCA1","description":"Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.12493873660829995,"antibodyCount":103,"monoclonalCount":24,"pubmedCount":null,"jensenScore":1.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":68,"knowledgeAvailability":29.49715594826688,"pubTatorScore":2.4301647332655043,"self":"https://pharos.nih.gov/idg/api/v1/targets(16356)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(16356)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(16356)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(16356)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(16356)/publications"},"_namespace":null},{"id":16357,"version":2,"created":1554991543000,"modified":1554991548000,"deprecated":false,"name":"Diamine acetyltransferase 1","accession":"P21673","gene":"SAT1","description":"Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.60045433640755,"antibodyCount":159,"monoclonalCount":25,"pubmedCount":null,"jensenScore":409.463577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.96088434817873,"pubTatorScore":2.4701307484798543,"self":"https://pharos.nih.gov/idg/api/v1/targets(16357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/publications"},"_namespace":null},{"id":16358,"version":2,"created":1554991549000,"modified":1554991554000,"deprecated":false,"name":"Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16","accession":"O60231","gene":"DHX16","description":"Probable ATP-binding RNA helicase involved in pre-mRNA splicing.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5197995371278126,"antibodyCount":78,"monoclonalCount":12,"pubmedCount":null,"jensenScore":31.371154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.20809997043004,"pubTatorScore":1.3530994742300868,"self":"https://pharos.nih.gov/idg/api/v1/targets(16358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/publications"},"_namespace":null},{"id":16359,"version":4,"created":1554991554000,"modified":1555043279000,"deprecated":false,"name":"Calpain-1 catalytic subunit","accession":"P07384","gene":"CAPN1","description":"Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.573734420348854,"antibodyCount":338,"monoclonalCount":73,"pubmedCount":null,"jensenScore":361.880383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":45.433732834792366,"pubTatorScore":2.3691450931960314,"self":"https://pharos.nih.gov/idg/api/v1/targets(16359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":584,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/properties"},"_links":{"count":1626,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/publications"},"_namespace":null},{"id":16360,"version":2,"created":1554991667000,"modified":1554991685000,"deprecated":false,"name":"BDNF/NT-3 growth factors receptor","accession":"Q16620","gene":"NTRK2","description":"Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.1447656216494635,"antibodyCount":947,"monoclonalCount":147,"pubmedCount":null,"jensenScore":1170.253701,"patentCount":64967,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.94212778699589,"pubTatorScore":2.7781488299089863,"self":"https://pharos.nih.gov/idg/api/v1/targets(16360)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":665,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/properties"},"_links":{"count":1379,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/links"},"_synonyms":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/synonyms"},"_publications":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/publications"},"_namespace":null},{"id":16361,"version":2,"created":1554991687000,"modified":1554991688000,"deprecated":false,"name":"Putative speedy protein E16","accession":"A6NNV3","gene":"SPDYE16","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/properties"},"_links":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/publications"},"_namespace":null},{"id":16362,"version":2,"created":1554991688000,"modified":1554991692000,"deprecated":false,"name":"Ras-related protein Rab-6A","accession":"P20340","gene":"RAB6A","description":"Protein transport. 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Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.094880635076589,"antibodyCount":207,"monoclonalCount":25,"pubmedCount":null,"jensenScore":134.458845,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.47270350836997,"pubTatorScore":1.9466094226824204,"self":"https://pharos.nih.gov/idg/api/v1/targets(16362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":494,"href":"https://pharos.nih.gov/idg/api/v1/targets(16362)/properties"},"_links":{"count":1298,"href":"https://pharos.nih.gov/idg/api/v1/targets(16362)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(16362)/synonyms"},"_publications":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16362)/publications"},"_namespace":null},{"id":16363,"version":2,"created":1554991694000,"modified":1554991698000,"deprecated":false,"name":"Transcription factor NF-E2 45 kDa subunit","accession":"Q16621","gene":"NFE2","description":"Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3646932240260754,"antibodyCount":110,"monoclonalCount":10,"pubmedCount":null,"jensenScore":208.99712,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.206778078440244,"pubTatorScore":2.305427830793789,"self":"https://pharos.nih.gov/idg/api/v1/targets(16363)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(16363)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(16363)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(16363)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(16363)/publications"},"_namespace":null},{"id":16364,"version":2,"created":1554991698000,"modified":1554991702000,"deprecated":false,"name":"3-hydroxyanthranilate 3,4-dioxygenase","accession":"P46952","gene":"HAAO","description":"Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7635859404405094,"antibodyCount":114,"monoclonalCount":17,"pubmedCount":null,"jensenScore":56.098302,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.55331327436599,"pubTatorScore":1.9572136676235707,"self":"https://pharos.nih.gov/idg/api/v1/targets(16364)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(16364)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(16364)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(16364)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(16364)/publications"},"_namespace":null},{"id":16365,"version":2,"created":1554991703000,"modified":1554991708000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 1","accession":"P21675","gene":"TAF1","description":"Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). 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Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.642154687845119,"antibodyCount":228,"monoclonalCount":55,"pubmedCount":null,"jensenScore":426.143304,"patentCount":14826,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.03117375865245,"pubTatorScore":2.289051390132761,"self":"https://pharos.nih.gov/idg/api/v1/targets(16365)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":608,"href":"https://pharos.nih.gov/idg/api/v1/targets(16365)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(16365)/links"},"_synonyms":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(16365)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(16365)/publications"},"_namespace":null},{"id":16366,"version":3,"created":1554991709000,"modified":1555043283000,"deprecated":false,"name":"Insulin-like growth factor-binding protein 1","accession":"P08833","gene":"IGFBP1","description":"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. 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Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from 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In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9135439588366526,"antibodyCount":207,"monoclonalCount":54,"pubmedCount":null,"jensenScore":10.656543,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.128604624722342,"pubTatorScore":1.218483906706644,"self":"https://pharos.nih.gov/idg/api/v1/targets(16468)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(16468)/properties"},"_links":{"count":754,"href":"https://pharos.nih.gov/idg/api/v1/targets(16468)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(16468)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(16468)/publications"},"_namespace":null},{"id":16469,"version":2,"created":1554992498000,"modified":1554992499000,"deprecated":false,"name":"Olfactory receptor 6V1","accession":"Q8N148","gene":"OR6V1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":59,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.111111,"patentCount":107,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.74663682225701,"pubTatorScore":-0.19188562274880874,"self":"https://pharos.nih.gov/idg/api/v1/targets(16469)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(16469)/properties"},"_links":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(16469)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(16469)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16469)/publications"},"_namespace":null},{"id":16470,"version":2,"created":1554992499000,"modified":1554992503000,"deprecated":false,"name":"ATP-binding cassette sub-family A member 6","accession":"Q8N139","gene":"ABCA6","description":"Probable transporter which may play a role in macrophage lipid homeostasis.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.7091334763725997,"antibodyCount":120,"monoclonalCount":18,"pubmedCount":null,"jensenScore":5.249699,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.681711377191373,"pubTatorScore":0.7103995225186777,"self":"https://pharos.nih.gov/idg/api/v1/targets(16470)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(16470)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(16470)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(16470)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(16470)/publications"},"_namespace":null},{"id":16471,"version":2,"created":1554992504000,"modified":1554992505000,"deprecated":false,"name":"Olfactory receptor 2F2","accession":"O95006","gene":"OR2F2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":231,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.238997992139518,"pubTatorScore":1.5233128140824437,"self":"https://pharos.nih.gov/idg/api/v1/targets(16471)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(16471)/properties"},"_links":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(16471)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(16471)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16471)/publications"},"_namespace":null},{"id":16472,"version":4,"created":1554992506000,"modified":1555043339000,"deprecated":false,"name":"Peroxisome proliferator-activated receptor delta","accession":"Q03181","gene":"PPARD","description":"Ligand-activated transcription factor. 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The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0893723939347693,"antibodyCount":167,"monoclonalCount":12,"pubmedCount":null,"jensenScore":122.497838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":34.04366491737123,"pubTatorScore":1.9833609482150518,"self":"https://pharos.nih.gov/idg/api/v1/targets(16474)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(16474)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(16474)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(16474)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(16474)/publications"},"_namespace":null},{"id":16475,"version":2,"created":1554992610000,"modified":1554992612000,"deprecated":false,"name":"Radial spoke head 10 homolog B","accession":"P0C881","gene":"RSPH10B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.713997396620098,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(16475)/properties"},"_links":{"count":731,"href":"https://pharos.nih.gov/idg/api/v1/targets(16475)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(16475)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(16475)/publications"},"_namespace":null},{"id":16476,"version":2,"created":1554992612000,"modified":1554992614000,"deprecated":false,"name":"Proline-rich protein 29","accession":"P0C7W0","gene":"PRR29","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.844010431196129,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(16476)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(16476)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(16476)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16476)/publications"},"_namespace":null},{"id":16477,"version":2,"created":1554992614000,"modified":1554992614000,"deprecated":false,"name":"Putative uncharacterized protein FLJ40606","accession":"P0C880","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(16477)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16477)/links"},"_synonyms":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(16477)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(16477)/publications"},"_namespace":null},{"id":16478,"version":2,"created":1554992614000,"modified":1554992617000,"deprecated":false,"name":"Protein lin-28 homolog A","accession":"Q9H9Z2","gene":"LIN28A","description":"RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4470861181302657,"antibodyCount":494,"monoclonalCount":204,"pubmedCount":null,"jensenScore":277.010625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.852575093411968,"pubTatorScore":2.322894449155244,"self":"https://pharos.nih.gov/idg/api/v1/targets(16478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(16478)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(16478)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(16478)/synonyms"},"_publications":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(16478)/publications"},"_namespace":null},{"id":16479,"version":2,"created":1554992618000,"modified":1554992628000,"deprecated":false,"name":"Wilms tumor protein","accession":"P19544","gene":"WT1","description":"Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). 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Required for efficient DNA double-stranded break repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4344867641325763,"antibodyCount":74,"monoclonalCount":4,"pubmedCount":null,"jensenScore":28.747579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.09327100911283,"pubTatorScore":1.2697295237649102,"self":"https://pharos.nih.gov/idg/api/v1/targets(16553)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/publications"},"_namespace":null},{"id":16554,"version":2,"created":1554992898000,"modified":1554992906000,"deprecated":false,"name":"Solute carrier family 22 member 8","accession":"Q8TCC7","gene":"SLC22A8","description":"Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. 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Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).","idgFamily":"Transporter","idgTDL":"Tclin","novelty":-2.4012630996424194,"antibodyCount":113,"monoclonalCount":9,"pubmedCount":null,"jensenScore":258.380271,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.486382914791243,"pubTatorScore":2.0865695549419674,"self":"https://pharos.nih.gov/idg/api/v1/targets(16554)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/properties"},"_links":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/publications"},"_namespace":null},{"id":16555,"version":2,"created":1554992906000,"modified":1554992917000,"deprecated":false,"name":"Cytosolic phospholipase A2 beta","accession":"P0C869","gene":"JMJD7-PLA2G4B","description":"Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. 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AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. 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Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.8843961442308323,"antibodyCount":667,"monoclonalCount":23,"pubmedCount":null,"jensenScore":775.188055,"patentCount":36268,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.30257676406188,"pubTatorScore":2.5654909310220453,"self":"https://pharos.nih.gov/idg/api/v1/targets(16561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":532,"href":"https://pharos.nih.gov/idg/api/v1/targets(16561)/properties"},"_links":{"count":1187,"href":"https://pharos.nih.gov/idg/api/v1/targets(16561)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(16561)/synonyms"},"_publications":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(16561)/publications"},"_namespace":null},{"id":16562,"version":2,"created":1554993046000,"modified":1554993057000,"deprecated":false,"name":"Neutrophil gelatinase-associated lipocalin","accession":"P80188","gene":"LCN2","description":"Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. 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Able to phosphorylate RPS6 in vitro.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.0336831762453245,"antibodyCount":153,"monoclonalCount":26,"pubmedCount":null,"jensenScore":117.595116,"patentCount":23344,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.69519919186985,"pubTatorScore":1.8483276563925464,"self":"https://pharos.nih.gov/idg/api/v1/targets(16716)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/publications"},"_namespace":null},{"id":16717,"version":3,"created":1554993768000,"modified":1555043452000,"deprecated":false,"name":"Transcription factor E2F3","accession":"O00716","gene":"E2F3","description":"Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. 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Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2700499772397453,"antibodyCount":259,"monoclonalCount":88,"pubmedCount":null,"jensenScore":133.328873,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.700593693206216,"pubTatorScore":2.1474242304649587,"self":"https://pharos.nih.gov/idg/api/v1/targets(16717)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/publications"},"_namespace":null},{"id":16718,"version":4,"created":1554993774000,"modified":1555043454000,"deprecated":false,"name":"Microsomal triglyceride transfer protein large subunit","accession":"P55157","gene":"MTTP","description":"Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). 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Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.0126363274643295,"antibodyCount":159,"monoclonalCount":41,"pubmedCount":null,"jensenScore":103.648019,"patentCount":16204,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.22446806559992,"pubTatorScore":1.6102375529304491,"self":"https://pharos.nih.gov/idg/api/v1/targets(16719)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/publications"},"_namespace":null},{"id":16720,"version":3,"created":1554993847000,"modified":1555043457000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 12","accession":"Q16514","gene":"TAF12","description":"TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1416002103977902,"antibodyCount":119,"monoclonalCount":14,"pubmedCount":null,"jensenScore":12.436943,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":37.31788154844032,"pubTatorScore":1.1971164051537904,"self":"https://pharos.nih.gov/idg/api/v1/targets(16720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/publications"},"_namespace":null},{"id":16721,"version":2,"created":1554993851000,"modified":1554993855000,"deprecated":false,"name":"Acid-sensing ion channel 2","accession":"Q16515","gene":"ASIC2","description":"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.4968278440078837,"antibodyCount":140,"monoclonalCount":3,"pubmedCount":null,"jensenScore":295.786194,"patentCount":25126,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.632494352431756,"pubTatorScore":1.8274974808662123,"self":"https://pharos.nih.gov/idg/api/v1/targets(16721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/properties"},"_links":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/publications"},"_namespace":null},{"id":16722,"version":2,"created":1554993856000,"modified":1554993858000,"deprecated":false,"name":"Protein LKAAEAR1","accession":"Q8TD35","gene":"LKAAEAR1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":39,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.751811769301662,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(16722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/properties"},"_links":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/publications"},"_namespace":null},{"id":16723,"version":2,"created":1554993859000,"modified":1554993861000,"deprecated":false,"name":"Putative uncharacterized protein C6orf52","accession":"Q5T4I8","gene":"C6orf52","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(16723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/publications"},"_namespace":null},{"id":16724,"version":2,"created":1554993861000,"modified":1554993864000,"deprecated":false,"name":"Basic leucine zipper transcriptional factor ATF-like","accession":"Q16520","gene":"BATF","description":"AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. 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Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. 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Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0755627422035328,"antibodyCount":127,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.179687,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.092849113977245,"pubTatorScore":0.8044801891059927,"self":"https://pharos.nih.gov/idg/api/v1/targets(16726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/publications"},"_namespace":null},{"id":16727,"version":3,"created":1554993872000,"modified":1555043458000,"deprecated":false,"name":"Netrin receptor DCC","accession":"P43146","gene":"DCC","description":"Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.055738479520367,"antibodyCount":222,"monoclonalCount":33,"pubmedCount":null,"jensenScore":103.630499,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":44.138854780919054,"pubTatorScore":2.5808521209403286,"self":"https://pharos.nih.gov/idg/api/v1/targets(16727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/publications"},"_namespace":null},{"id":16728,"version":2,"created":1554993878000,"modified":1554993882000,"deprecated":false,"name":"Disks large-associated protein 2","accession":"Q9P1A6","gene":"DLGAP2","description":"May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3406053613966402,"antibodyCount":54,"monoclonalCount":1,"pubmedCount":null,"jensenScore":22.602093,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.48503863564657,"pubTatorScore":1.3644626266660633,"self":"https://pharos.nih.gov/idg/api/v1/targets(16728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/publications"},"_namespace":null},{"id":16729,"version":3,"created":1554993882000,"modified":1555043460000,"deprecated":false,"name":"F-box/LRR-repeat protein 19","accession":"Q6PCT2","gene":"FBXL19","description":"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6058961391703037,"antibodyCount":81,"monoclonalCount":4,"pubmedCount":null,"jensenScore":4.228856,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":32.60935569018493,"pubTatorScore":0.4057116764783553,"self":"https://pharos.nih.gov/idg/api/v1/targets(16729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/publications"},"_namespace":null},{"id":16730,"version":2,"created":1554993886000,"modified":1554993891000,"deprecated":false,"name":"Cysteine and glycine-rich protein 2","accession":"Q16527","gene":"CSRP2","description":"Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. 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By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0881065793930733,"antibodyCount":133,"monoclonalCount":22,"pubmedCount":null,"jensenScore":122.348666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.454041931998745,"pubTatorScore":3.0848517687953922,"self":"https://pharos.nih.gov/idg/api/v1/targets(16732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/publications"},"_namespace":null},{"id":16733,"version":3,"created":1554993903000,"modified":1555043463000,"deprecated":false,"name":"Sideroflexin-5","accession":"Q8TD22","gene":"SFXN5","description":"Transports citrate. Potential iron transporter (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.35364233300200976,"antibodyCount":33,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.186147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":30.318097561379428,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(16733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/publications"},"_namespace":null},{"id":16734,"version":3,"created":1554993907000,"modified":1555043464000,"deprecated":false,"name":"Cryptochrome-1","accession":"Q16526","gene":"CRY1","description":"Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.619692862178446,"antibodyCount":180,"monoclonalCount":41,"pubmedCount":null,"jensenScore":400.803917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":41.75292067674953,"pubTatorScore":2.1053683908751215,"self":"https://pharos.nih.gov/idg/api/v1/targets(16734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":484,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/publications"},"_namespace":null},{"id":16735,"version":2,"created":1554993913000,"modified":1554993918000,"deprecated":false,"name":"S-adenosylmethionine synthase isoform type-2","accession":"P31153","gene":"MAT2A","description":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9196892488114052,"antibodyCount":242,"monoclonalCount":54,"pubmedCount":null,"jensenScore":84.105088,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.46065699131382,"pubTatorScore":1.7746902620909737,"self":"https://pharos.nih.gov/idg/api/v1/targets(16735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/publications"},"_namespace":null},{"id":16736,"version":3,"created":1554993919000,"modified":1555043466000,"deprecated":false,"name":"Intraflagellar transport protein 43 homolog","accession":"Q96FT9","gene":"IFT43","description":"Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.224275259852618,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":144.116613,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":29.734099418257564,"pubTatorScore":1.554441051805542,"self":"https://pharos.nih.gov/idg/api/v1/targets(16736)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/publications"},"_namespace":null},{"id":16737,"version":3,"created":1554993924000,"modified":1555043467000,"deprecated":false,"name":"Mitogen-activated protein kinase 4","accession":"P31152","gene":"MAPK4","description":"Atypical MAPK protein. 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May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5502336579945906,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":35.117995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.617940749210447,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(16738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/publications"},"_namespace":null},{"id":16739,"version":3,"created":1554993933000,"modified":1555043470000,"deprecated":false,"name":"Acid-sensing ion channel 4","accession":"Q96FT7","gene":"ASIC4","description":"Probable cation channel with high affinity for sodium. 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Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.623028160524211,"antibodyCount":77,"monoclonalCount":1,"pubmedCount":null,"jensenScore":45.328097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.818232661644466,"pubTatorScore":1.3374191645744546,"self":"https://pharos.nih.gov/idg/api/v1/targets(16741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/publications"},"_namespace":null},{"id":16742,"version":2,"created":1554993950000,"modified":1554993956000,"deprecated":false,"name":"HLA class I histocompatibility antigen, B-67 alpha chain","accession":"Q29836","gene":"HLA-B","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8875247029897861,"antibodyCount":362,"monoclonalCount":184,"pubmedCount":null,"jensenScore":1613.472112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.7801564385417628,"self":"https://pharos.nih.gov/idg/api/v1/targets(16742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1932,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/properties"},"_links":{"count":1505,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/synonyms"},"_publications":{"count":1770,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/publications"},"_namespace":null},{"id":16743,"version":2,"created":1554993960000,"modified":1554993974000,"deprecated":false,"name":"2-5A-dependent ribonuclease","accession":"Q05823","gene":"RNASEL","description":"Endoribonuclease that functions in the interferon (IFN) antiviral response. 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Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.716730439757016,"antibodyCount":127,"monoclonalCount":48,"pubmedCount":null,"jensenScore":525.762681,"patentCount":24366,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.728602939990466,"pubTatorScore":2.5989202047021496,"self":"https://pharos.nih.gov/idg/api/v1/targets(16743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":534,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/publications"},"_namespace":null},{"id":16744,"version":3,"created":1554993976000,"modified":1555043471000,"deprecated":false,"name":"Protrudin","accession":"Q5T4F4","gene":"ZFYVE27","description":"Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). 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The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3471939830197788,"antibodyCount":353,"monoclonalCount":77,"pubmedCount":null,"jensenScore":202.523473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.97512941627025,"pubTatorScore":2.1159342282522915,"self":"https://pharos.nih.gov/idg/api/v1/targets(16745)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/properties"},"_links":{"count":1211,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/links"},"_synonyms":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/publications"},"_namespace":null},{"id":16746,"version":3,"created":1554993989000,"modified":1555043473000,"deprecated":false,"name":"snRNA-activating protein complex subunit 1","accession":"Q16533","gene":"SNAPC1","description":"Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. 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Recruits TBP and BRF2 to the U6 snRNA TATA box.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7306669516590141,"antibodyCount":128,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.92074,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":30.470850442744506,"pubTatorScore":0.8327139407113583,"self":"https://pharos.nih.gov/idg/api/v1/targets(16746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/publications"},"_namespace":null},{"id":16747,"version":2,"created":1554993996000,"modified":1554993999000,"deprecated":false,"name":"Secreted frizzled-related protein 5","accession":"Q5T4F7","gene":"SFRP5","description":"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. 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Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5568699035071527,"antibodyCount":87,"monoclonalCount":27,"pubmedCount":null,"jensenScore":34.193826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.49323183847568,"pubTatorScore":0.6976929531205318,"self":"https://pharos.nih.gov/idg/api/v1/targets(16782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/publications"},"_namespace":null},{"id":16783,"version":2,"created":1554994637000,"modified":1554994641000,"deprecated":false,"name":"Prokineticin receptor 1","accession":"Q8TCW9","gene":"PROKR1","description":"Receptor for prokineticin 1. 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The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6815071764925813,"antibodyCount":281,"monoclonalCount":119,"pubmedCount":null,"jensenScore":49.977391,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.83896418516543,"pubTatorScore":1.4617503565608407,"self":"https://pharos.nih.gov/idg/api/v1/targets(16831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/publications"},"_namespace":null},{"id":16832,"version":3,"created":1554995031000,"modified":1555043544000,"deprecated":false,"name":"Cyclin-Q","accession":"Q8N1B3","gene":"CCNQ","description":"Activating cyclin for the cyclin-associated kinase CDK10.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8902588677511418,"antibodyCount":14,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.30982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":0.5622928644564748,"self":"https://pharos.nih.gov/idg/api/v1/targets(16832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/properties"},"_links":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/publications"},"_namespace":null},{"id":16833,"version":2,"created":1554995032000,"modified":1554995035000,"deprecated":false,"name":"Calcium-binding protein 4","accession":"P57796","gene":"CABP4","description":"Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5790577244364854,"antibodyCount":144,"monoclonalCount":27,"pubmedCount":null,"jensenScore":38.725806,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.63639905446509,"pubTatorScore":1.1809792824690748,"self":"https://pharos.nih.gov/idg/api/v1/targets(16833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/publications"},"_namespace":null},{"id":16834,"version":2,"created":1554995036000,"modified":1554995039000,"deprecated":false,"name":"Signal peptide peptidase-like 3","accession":"Q8TCT6","gene":"SPPL3","description":"Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3676886107237498,"antibodyCount":88,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.896859,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.77548191664153,"pubTatorScore":1.083169748190052,"self":"https://pharos.nih.gov/idg/api/v1/targets(16834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/publications"},"_namespace":null},{"id":16835,"version":2,"created":1554995040000,"modified":1554995044000,"deprecated":false,"name":"Dynein heavy chain 3, axonemal","accession":"Q8TD57","gene":"DNAH3","description":"Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.1583265617933391,"antibodyCount":12,"monoclonalCount":1,"pubmedCount":null,"jensenScore":13.845539,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.988363269856244,"pubTatorScore":0.48952312351560606,"self":"https://pharos.nih.gov/idg/api/v1/targets(16835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/publications"},"_namespace":null},{"id":16836,"version":3,"created":1554995045000,"modified":1555043545000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 52 homolog","accession":"Q8N1B4","gene":"VPS52","description":"Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6756136146207612,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":40.503807,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.43349263455112,"pubTatorScore":2.8147468784989904,"self":"https://pharos.nih.gov/idg/api/v1/targets(16836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/publications"},"_namespace":null},{"id":16837,"version":3,"created":1554995049000,"modified":1555043548000,"deprecated":false,"name":"Signal peptide peptidase-like 2B","accession":"Q8TCT7","gene":"SPPL2B","description":"Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":77,"knowledgeAvailability":29.50927986870489,"pubTatorScore":1.2355584677384677,"self":"https://pharos.nih.gov/idg/api/v1/targets(16837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/properties"},"_links":{"count":804,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/publications"},"_namespace":null},{"id":16838,"version":2,"created":1554995053000,"modified":1554995058000,"deprecated":false,"name":"Signal peptide peptidase-like 2A","accession":"Q8TCT8","gene":"SPPL2A","description":"Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3403539637945312,"antibodyCount":84,"monoclonalCount":6,"pubmedCount":null,"jensenScore":24.035552,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.2445647565235,"pubTatorScore":1.1900091357734188,"self":"https://pharos.nih.gov/idg/api/v1/targets(16838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/publications"},"_namespace":null},{"id":16839,"version":2,"created":1554995059000,"modified":1554995064000,"deprecated":false,"name":"Minor histocompatibility antigen H13","accession":"Q8TCT9","gene":"HM13","description":"Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4806052046189824,"antibodyCount":113,"monoclonalCount":2,"pubmedCount":null,"jensenScore":278.808411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.97606337230304,"pubTatorScore":2.6081780596289543,"self":"https://pharos.nih.gov/idg/api/v1/targets(16839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/properties"},"_links":{"count":1211,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/publications"},"_namespace":null},{"id":16840,"version":2,"created":1554995065000,"modified":1554995068000,"deprecated":false,"name":"Zinc finger protein 630","accession":"Q2M218","gene":"ZNF630","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.7,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.62290981755242,"pubTatorScore":0.09691001300805642,"self":"https://pharos.nih.gov/idg/api/v1/targets(16840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/publications"},"_namespace":null},{"id":16841,"version":3,"created":1554995068000,"modified":1555043549000,"deprecated":false,"name":"Ceramide kinase-like protein","accession":"Q49MI3","gene":"CERKL","description":"Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1428014920195833,"antibodyCount":99,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.985479,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":29.280803420784995,"pubTatorScore":1.4322118686338456,"self":"https://pharos.nih.gov/idg/api/v1/targets(16841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/publications"},"_namespace":null},{"id":16842,"version":3,"created":1554995073000,"modified":1555043550000,"deprecated":false,"name":"Kinesin-like protein KIF7","accession":"Q2M1P5","gene":"KIF7","description":"Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5055988190051002,"antibodyCount":64,"monoclonalCount":11,"pubmedCount":null,"jensenScore":33.4443,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.224113115074367,"pubTatorScore":1.4283048971954762,"self":"https://pharos.nih.gov/idg/api/v1/targets(16842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/publications"},"_namespace":null},{"id":16843,"version":2,"created":1554995078000,"modified":1554995085000,"deprecated":false,"name":"Beta-sarcoglycan","accession":"Q16585","gene":"SGCB","description":"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular 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of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular 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74","accession":"Q16587","gene":"ZNF74","description":"May play a role in RNA metabolism.","idgFamily":"Transcription 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hydration of carbon 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Together with MYO5B regulates transcytosis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7959473382062718,"antibodyCount":212,"monoclonalCount":66,"pubmedCount":null,"jensenScore":62.735189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.919181715008527,"pubTatorScore":1.7041898333016292,"self":"https://pharos.nih.gov/idg/api/v1/targets(16893)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/publications"},"_namespace":null},{"id":16894,"version":2,"created":1554995500000,"modified":1554995505000,"deprecated":false,"name":"Polypeptide N-acetylgalactosaminyltransferase 14","accession":"Q96FL9","gene":"GALNT14","description":"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. 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Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.104907997147778,"antibodyCount":103,"monoclonalCount":1,"pubmedCount":null,"jensenScore":126.585921,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.317737583996742,"pubTatorScore":1.8457777618740048,"self":"https://pharos.nih.gov/idg/api/v1/targets(16895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/publications"},"_namespace":null},{"id":16896,"version":2,"created":1554995552000,"modified":1554995552000,"deprecated":false,"name":"Putative uncharacterized protein C12orf77","accession":"C9JDV5","gene":"C12orf77","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/publications"},"_namespace":null},{"id":16897,"version":2,"created":1554995552000,"modified":1554995553000,"deprecated":false,"name":"Putative uncharacterized protein ZNF295-AS1","accession":"Q8N0V1","gene":"ZNF295-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.579469636587316,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/publications"},"_namespace":null},{"id":16898,"version":3,"created":1554995553000,"modified":1555043598000,"deprecated":false,"name":"Leucine-rich repeat LGI family member 2","accession":"Q8N0V4","gene":"LGI2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8889012516115797,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.8404,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.464215419317455,"pubTatorScore":0.794720328592532,"self":"https://pharos.nih.gov/idg/api/v1/targets(16898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/properties"},"_links":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/publications"},"_namespace":null},{"id":16899,"version":3,"created":1554995557000,"modified":1555043599000,"deprecated":false,"name":"Protein pitchfork","accession":"Q8TCI5","gene":"PIFO","description":"During primary cilia disassembly, involved in cilia disassembly. 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May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.532784638646088,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.609052,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":20.588877396295292,"pubTatorScore":1.8702087566935173,"self":"https://pharos.nih.gov/idg/api/v1/targets(16899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/properties"},"_links":{"count":847,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/publications"},"_namespace":null},{"id":16900,"version":3,"created":1554995561000,"modified":1555043600000,"deprecated":false,"name":"Putative ribosome-binding factor A, mitochondrial","accession":"Q8N0V3","gene":"RBFA","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9526310391801692,"antibodyCount":54,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.440044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":27.943710508842347,"pubTatorScore":0.3222192947339193,"self":"https://pharos.nih.gov/idg/api/v1/targets(16900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/properties"},"_links":{"count":909,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/publications"},"_namespace":null},{"id":16901,"version":3,"created":1554995564000,"modified":1555043601000,"deprecated":false,"name":"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase","accession":"Q8N0V5","gene":"GCNT2","description":"Isoform C: Determines the expression of the blood group I antigen in erythrocytes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8777821551151042,"antibodyCount":179,"monoclonalCount":2,"pubmedCount":null,"jensenScore":71.628891,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":45.48207719946515,"pubTatorScore":1.555382378662851,"self":"https://pharos.nih.gov/idg/api/v1/targets(16901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/publications"},"_namespace":null},{"id":16902,"version":2,"created":1554995570000,"modified":1554995574000,"deprecated":false,"name":"Calmodulin-regulated spectrin-associated protein 2","accession":"Q08AD1","gene":"CAMSAP2","description":"Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8145805301248895,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.80083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.747460928341546,"pubTatorScore":0.865301406361885,"self":"https://pharos.nih.gov/idg/api/v1/targets(16902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/publications"},"_namespace":null},{"id":16903,"version":2,"created":1554995576000,"modified":1554995580000,"deprecated":false,"name":"Keratin, type I cytoskeletal 16","accession":"P08779","gene":"KRT16","description":"Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2053760397403708,"antibodyCount":389,"monoclonalCount":141,"pubmedCount":null,"jensenScore":149.329912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.45291691206872,"pubTatorScore":2.3138823719225257,"self":"https://pharos.nih.gov/idg/api/v1/targets(16903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/publications"},"_namespace":null},{"id":16904,"version":2,"created":1554995580000,"modified":1554995600000,"deprecated":false,"name":"Voltage-dependent T-type calcium channel subunit alpha-1I","accession":"Q9P0X4","gene":"CACNA1I","description":"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the \"low-voltage activated (LVA)\" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.9544607103633358,"antibodyCount":79,"monoclonalCount":36,"pubmedCount":null,"jensenScore":85.601066,"patentCount":1366,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.43877811774742,"pubTatorScore":1.411332976974196,"self":"https://pharos.nih.gov/idg/api/v1/targets(16904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/publications"},"_namespace":null},{"id":16905,"version":2,"created":1554995601000,"modified":1554995602000,"deprecated":false,"name":"Putative serine protease 46","accession":"E5RG02","gene":"PRSS46P","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":1.1760912590556813,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/properties"},"_links":{"count":580,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/publications"},"_namespace":null},{"id":16906,"version":2,"created":1554995603000,"modified":1554995608000,"deprecated":false,"name":"Nuclear pore complex protein Nup107","accession":"P57740","gene":"NUP107","description":"Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4902109712752694,"antibodyCount":165,"monoclonalCount":4,"pubmedCount":null,"jensenScore":31.493171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.651794434836816,"pubTatorScore":1.4633799947757158,"self":"https://pharos.nih.gov/idg/api/v1/targets(16906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/publications"},"_namespace":null},{"id":16907,"version":2,"created":1554995609000,"modified":1554995613000,"deprecated":false,"name":"Lamin-B2","accession":"Q03252","gene":"LMNB2","description":"Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.006613594976143,"antibodyCount":208,"monoclonalCount":82,"pubmedCount":null,"jensenScore":99.051594,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.54332046258415,"pubTatorScore":1.8722998867993867,"self":"https://pharos.nih.gov/idg/api/v1/targets(16907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/properties"},"_links":{"count":1063,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/publications"},"_namespace":null},{"id":16908,"version":3,"created":1554995614000,"modified":1555043603000,"deprecated":false,"name":"Troponin I, cardiac muscle","accession":"P19429","gene":"TNNI3","description":"Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.5528109487312003,"antibodyCount":1706,"monoclonalCount":1087,"pubmedCount":null,"jensenScore":3485.562815,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.85839824450499,"pubTatorScore":3.2149668606902027,"self":"https://pharos.nih.gov/idg/api/v1/targets(16908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":606,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/synonyms"},"_publications":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/publications"},"_namespace":null},{"id":16909,"version":2,"created":1554995621000,"modified":1554995621000,"deprecated":false,"name":"Putative uncharacterized protein FLJ23865","accession":"Q8TCH9","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/publications"},"_namespace":null},{"id":16910,"version":3,"created":1554995621000,"modified":1555043605000,"deprecated":false,"name":"Cell cycle and apoptosis regulator protein 2","accession":"Q8N163","gene":"CCAR2","description":"Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro 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Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0300811193091315,"antibodyCount":268,"monoclonalCount":23,"pubmedCount":null,"jensenScore":1099.34826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.94945082090208,"pubTatorScore":2.985680286120373,"self":"https://pharos.nih.gov/idg/api/v1/targets(16980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":498,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/synonyms"},"_publications":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/publications"},"_namespace":null},{"id":16981,"version":3,"created":1554996196000,"modified":1555043672000,"deprecated":false,"name":"Transmembrane protein 9","accession":"Q9P0T7","gene":"TMEM9","description":"May be involved in intracellular transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8650193305572615,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.924836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":83,"knowledgeAvailability":30.2230541448633,"pubTatorScore":0.10914437291517246,"self":"https://pharos.nih.gov/idg/api/v1/targets(16981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/publications"},"_namespace":null},{"id":16982,"version":3,"created":1554996200000,"modified":1555043673000,"deprecated":false,"name":"Early growth response protein 1","accession":"P18146","gene":"EGR1","description":"Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.2981730696028606,"antibodyCount":394,"monoclonalCount":175,"pubmedCount":null,"jensenScore":2034.616214,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":50.560283904104814,"pubTatorScore":3.013613798203982,"self":"https://pharos.nih.gov/idg/api/v1/targets(16982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/properties"},"_links":{"count":1410,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/synonyms"},"_publications":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/publications"},"_namespace":null},{"id":16983,"version":2,"created":1554996210000,"modified":1554996211000,"deprecated":false,"name":"Olfactory receptor 4N4","accession":"Q8N0Y3","gene":"OR4N4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.037788560527487726,"antibodyCount":70,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.875,"patentCount":249,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.32701925613628,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(16983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/properties"},"_links":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/publications"},"_namespace":null},{"id":16984,"version":2,"created":1554996211000,"modified":1554996217000,"deprecated":false,"name":"PH domain leucine-rich repeat-containing protein phosphatase 1","accession":"O60346","gene":"PHLPP1","description":"Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.9889737167453667,"antibodyCount":128,"monoclonalCount":0,"pubmedCount":null,"jensenScore":103.862427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.2150555210458,"pubTatorScore":2.0028891064955046,"self":"https://pharos.nih.gov/idg/api/v1/targets(16984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/publications"},"_namespace":null},{"id":16985,"version":2,"created":1554996218000,"modified":1554996222000,"deprecated":false,"name":"TBC1 domain family member 12","accession":"O60347","gene":"TBC1D12","description":"May act as a GTPase-activating protein for Rab family protein(s).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.365801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.940603044514877,"pubTatorScore":-1.255269030761348,"self":"https://pharos.nih.gov/idg/api/v1/targets(16985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/publications"},"_namespace":null},{"id":16986,"version":3,"created":1554996223000,"modified":1555043676000,"deprecated":false,"name":"Zinc finger protein 444","accession":"Q8N0Y2","gene":"ZNF444","description":"Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.30068518116440457,"antibodyCount":65,"monoclonalCount":8,"pubmedCount":null,"jensenScore":1.389325,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":31.183183524783857,"pubTatorScore":0.5702391777754187,"self":"https://pharos.nih.gov/idg/api/v1/targets(16986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/publications"},"_namespace":null},{"id":16987,"version":3,"created":1554996227000,"modified":1555043677000,"deprecated":false,"name":"Endothelin-converting enzyme 2","accession":"O60344","gene":"ECE2","description":"Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid-beta peptide accumulation in brain. May also have methyltransferase activity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.4416546130788872,"antibodyCount":84,"monoclonalCount":3,"pubmedCount":null,"jensenScore":26.807623,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.567646623972855,"pubTatorScore":1.4507108319944746,"self":"https://pharos.nih.gov/idg/api/v1/targets(16987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/properties"},"_links":{"count":861,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/publications"},"_namespace":null},{"id":16988,"version":2,"created":1554996233000,"modified":1554996234000,"deprecated":false,"name":"Olfactory receptor 8I2","accession":"Q8N0Y5","gene":"OR8I2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":40,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":235,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.775161858395315,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/properties"},"_links":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/publications"},"_namespace":null},{"id":16989,"version":2,"created":1554996234000,"modified":1554996236000,"deprecated":false,"name":"Probable phosphoglycerate mutase 4","accession":"Q8N0Y7","gene":"PGAM4","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1984552529405341,"antibodyCount":75,"monoclonalCount":12,"pubmedCount":null,"jensenScore":14.467355,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.630305304184365,"pubTatorScore":1.0107238230215778,"self":"https://pharos.nih.gov/idg/api/v1/targets(16989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/publications"},"_namespace":null},{"id":16990,"version":2,"created":1554996237000,"modified":1554996240000,"deprecated":false,"name":"Protein PAT1 homolog 2","accession":"C9JE40","gene":"PATL2","description":"RNA-binding protein that acts as a translational repressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8218097515346166,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.889851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.50736207400636,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(16990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/publications"},"_namespace":null},{"id":16991,"version":2,"created":1554996240000,"modified":1554996245000,"deprecated":false,"name":"TBC1 domain family member 4","accession":"O60343","gene":"TBC1D4","description":"May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.067506448992282,"antibodyCount":300,"monoclonalCount":25,"pubmedCount":null,"jensenScore":113.51027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.97578045313792,"pubTatorScore":1.9185689474209213,"self":"https://pharos.nih.gov/idg/api/v1/targets(16991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":468,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/properties"},"_links":{"count":1134,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/publications"},"_namespace":null},{"id":16992,"version":3,"created":1554996246000,"modified":1555043678000,"deprecated":false,"name":"Gastrin-releasing peptide","accession":"P07492","gene":"GRP","description":"Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.4104189796601356,"antibodyCount":199,"monoclonalCount":9,"pubmedCount":null,"jensenScore":2788.91743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":26.23619185548866,"pubTatorScore":3.1818791446356047,"self":"https://pharos.nih.gov/idg/api/v1/targets(16992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/properties"},"_links":{"count":661,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/publications"},"_namespace":null},{"id":16993,"version":4,"created":1554996253000,"modified":1555043679000,"deprecated":false,"name":"Lysine-specific histone demethylase 1A","accession":"O60341","gene":"KDM1A","description":"Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.6869177485408855,"antibodyCount":473,"monoclonalCount":92,"pubmedCount":null,"jensenScore":516.27076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.8715087069576,"pubTatorScore":2.512773240098752,"self":"https://pharos.nih.gov/idg/api/v1/targets(16993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":681,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/properties"},"_links":{"count":1498,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/links"},"_synonyms":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/publications"},"_namespace":null},{"id":16994,"version":3,"created":1554996332000,"modified":1555043682000,"deprecated":false,"name":"Fibroblast growth factor 7","accession":"P21781","gene":"FGF7","description":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. 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Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).","idgFamily":"Transcription 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Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4826641999203387,"antibodyCount":320,"monoclonalCount":162,"pubmedCount":null,"jensenScore":290.46647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":32.70630084720051,"pubTatorScore":1.794919610107387,"self":"https://pharos.nih.gov/idg/api/v1/targets(17262)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(17262)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(17262)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(17262)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(17262)/publications"},"_namespace":null},{"id":17263,"version":2,"created":1554999234000,"modified":1554999238000,"deprecated":false,"name":"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1","accession":"P16118","gene":"PFKFB1","description":"Synthesis and degradation of fructose 2,6-bisphosphate.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.3328409724512893,"antibodyCount":214,"monoclonalCount":3,"pubmedCount":null,"jensenScore":17.604506,"patentCount":886,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.08629221966875,"pubTatorScore":1.2407001019730721,"self":"https://pharos.nih.gov/idg/api/v1/targets(17263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(17263)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(17263)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(17263)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(17263)/publications"},"_namespace":null},{"id":17264,"version":2,"created":1554999239000,"modified":1554999243000,"deprecated":false,"name":"Endothelial differentiation-related factor 1","accession":"O60869","gene":"EDF1","description":"Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.797941831080026,"antibodyCount":141,"monoclonalCount":13,"pubmedCount":null,"jensenScore":67.224986,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.05479141674583,"pubTatorScore":1.4543275587499311,"self":"https://pharos.nih.gov/idg/api/v1/targets(17264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/properties"},"_links":{"count":1129,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/publications"},"_namespace":null},{"id":17265,"version":4,"created":1554999244000,"modified":1555043883000,"deprecated":false,"name":"RAC-beta serine/threonine-protein kinase","accession":"P31751","gene":"AKT2","description":"One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on 'Thr-343'.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.605672671282355,"antibodyCount":1173,"monoclonalCount":318,"pubmedCount":null,"jensenScore":332.48537,"patentCount":36100,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":58.01224160453391,"pubTatorScore":2.450611991435829,"self":"https://pharos.nih.gov/idg/api/v1/targets(17265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/properties"},"_links":{"count":1565,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/links"},"_synonyms":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/synonyms"},"_publications":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/publications"},"_namespace":null},{"id":17266,"version":2,"created":1554999341000,"modified":1554999345000,"deprecated":false,"name":"Probable fibrosin-1","accession":"Q9HAH7","gene":"FBRS","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6542568351492941,"antibodyCount":33,"monoclonalCount":2,"pubmedCount":null,"jensenScore":42.915079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.761725723660923,"pubTatorScore":1.2382851001502533,"self":"https://pharos.nih.gov/idg/api/v1/targets(17266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/publications"},"_namespace":null},{"id":17267,"version":3,"created":1554999346000,"modified":1555043886000,"deprecated":false,"name":"Calcium uptake protein 1, mitochondrial","accession":"Q9BPX6","gene":"MICU1","description":"Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.518361051705193,"antibodyCount":110,"monoclonalCount":15,"pubmedCount":null,"jensenScore":321.558507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":37.29272295027732,"pubTatorScore":1.9701078229392908,"self":"https://pharos.nih.gov/idg/api/v1/targets(17267)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(17267)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(17267)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(17267)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(17267)/publications"},"_namespace":null},{"id":17268,"version":2,"created":1554999352000,"modified":1554999358000,"deprecated":false,"name":"Transmembrane protein 56","accession":"Q96MV1","gene":"TMEM56","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.1815541542505065,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.540909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.00935812146351,"pubTatorScore":-0.4423592820895424,"self":"https://pharos.nih.gov/idg/api/v1/targets(17268)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(17268)/properties"},"_links":{"count":840,"href":"https://pharos.nih.gov/idg/api/v1/targets(17268)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(17268)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(17268)/publications"},"_namespace":null},{"id":17269,"version":3,"created":1554999359000,"modified":1555043887000,"deprecated":false,"name":"UPF0415 protein C7orf25","accession":"Q9BPX7","gene":"C7orf25","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17269)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(17269)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(17269)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(17269)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(17269)/publications"},"_namespace":null},{"id":17270,"version":3,"created":1554999364000,"modified":1555043889000,"deprecated":false,"name":"Kelch domain-containing protein 3","accession":"Q9BQ90","gene":"KLHDC3","description":"May be involved in meiotic recombination process.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.42720077076025864,"antibodyCount":44,"monoclonalCount":4,"pubmedCount":null,"jensenScore":2.558824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":31.566827230286403,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(17270)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(17270)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(17270)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(17270)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(17270)/publications"},"_namespace":null},{"id":17271,"version":2,"created":1554999369000,"modified":1554999374000,"deprecated":false,"name":"Dedicator of cytokinesis protein 7","accession":"Q96N67","gene":"DOCK7","description":"Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2138197809091313,"antibodyCount":63,"monoclonalCount":9,"pubmedCount":null,"jensenScore":17.102199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.39837398431697,"pubTatorScore":1.0265072796170152,"self":"https://pharos.nih.gov/idg/api/v1/targets(17271)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(17271)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(17271)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(17271)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(17271)/publications"},"_namespace":null},{"id":17272,"version":2,"created":1554999375000,"modified":1554999381000,"deprecated":false,"name":"YTH domain-containing protein 1","accession":"Q96MU7","gene":"YTHDC1","description":"Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4000717549200665,"antibodyCount":44,"monoclonalCount":2,"pubmedCount":null,"jensenScore":22.465374,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.066473628230696,"pubTatorScore":1.1993763753088569,"self":"https://pharos.nih.gov/idg/api/v1/targets(17272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/properties"},"_links":{"count":1061,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/publications"},"_namespace":null},{"id":17273,"version":2,"created":1554999382000,"modified":1554999391000,"deprecated":false,"name":"Growth arrest-specific protein 7","accession":"O60861","gene":"GAS7","description":"May play a role in promoting maturation and morphological differentiation of cerebellar neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4300899331722574,"antibodyCount":241,"monoclonalCount":109,"pubmedCount":null,"jensenScore":28.840142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.14976673049878,"pubTatorScore":1.0995847957578984,"self":"https://pharos.nih.gov/idg/api/v1/targets(17273)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/publications"},"_namespace":null},{"id":17274,"version":2,"created":1554999392000,"modified":1554999398000,"deprecated":false,"name":"Zinc finger protein 778","accession":"Q96MU6","gene":"ZNF778","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.15126767714020944,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.037684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.07185003096348,"pubTatorScore":0.33579196829410124,"self":"https://pharos.nih.gov/idg/api/v1/targets(17274)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/publications"},"_namespace":null},{"id":17275,"version":2,"created":1554999400000,"modified":1554999405000,"deprecated":false,"name":"17-beta-hydroxysteroid dehydrogenase 14","accession":"Q9BPX1","gene":"HSD17B14","description":"Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. 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Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-0.761221711517869,"antibodyCount":84,"monoclonalCount":9,"pubmedCount":null,"jensenScore":5.514999,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.808794682922514,"pubTatorScore":0.6766936096248666,"self":"https://pharos.nih.gov/idg/api/v1/targets(17275)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(17275)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(17275)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(17275)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17275)/publications"},"_namespace":null},{"id":17276,"version":2,"created":1554999406000,"modified":1554999411000,"deprecated":false,"name":"Lysophospholipid acyltransferase 7","accession":"Q96N66","gene":"MBOAT7","description":"Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. 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Required for cortical lamination during brain development (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.311753841512503,"antibodyCount":104,"monoclonalCount":18,"pubmedCount":null,"jensenScore":19.351874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.35935036979859,"pubTatorScore":0.6351484466250962,"self":"https://pharos.nih.gov/idg/api/v1/targets(17276)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(17276)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(17276)/links"},"_synonyms":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(17276)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(17276)/publications"},"_namespace":null},{"id":17277,"version":2,"created":1554999412000,"modified":1554999418000,"deprecated":false,"name":"Kremen protein 1","accession":"Q96MU8","gene":"KREMEN1","description":"Receptor for Dickkopf proteins. 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Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2509911570565069,"antibodyCount":263,"monoclonalCount":46,"pubmedCount":null,"jensenScore":14.543814,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.37653852931777,"pubTatorScore":1.1752265291082598,"self":"https://pharos.nih.gov/idg/api/v1/targets(17277)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(17277)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(17277)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(17277)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(17277)/publications"},"_namespace":null},{"id":17278,"version":2,"created":1554999419000,"modified":1554999420000,"deprecated":false,"name":"Putative uncharacterized protein C18orf15","accession":"Q96N68","gene":"C18orf15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17278)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17278)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(17278)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17278)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(17278)/publications"},"_namespace":null},{"id":17279,"version":3,"created":1554999420000,"modified":1555043891000,"deprecated":false,"name":"Zinc finger protein 556","accession":"Q9HAH1","gene":"ZNF556","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":14.993373381123442,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(17279)/properties"},"_links":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(17279)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(17279)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(17279)/publications"},"_namespace":null},{"id":17280,"version":2,"created":1554999423000,"modified":1554999428000,"deprecated":false,"name":"Leucine zipper putative tumor suppressor 1","accession":"Q9Y250","gene":"LZTS1","description":"Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. 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Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.628805891873972,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(17281)/properties"},"_links":{"count":673,"href":"https://pharos.nih.gov/idg/api/v1/targets(17281)/links"},"_synonyms":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(17281)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(17281)/publications"},"_namespace":null},{"id":17282,"version":4,"created":1554999433000,"modified":1555043892000,"deprecated":false,"name":"Heparanase","accession":"Q9Y251","gene":"HPSE","description":"Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.971689076691492,"antibodyCount":355,"monoclonalCount":51,"pubmedCount":null,"jensenScore":906.437874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.674200842704934,"pubTatorScore":2.7922450623421575,"self":"https://pharos.nih.gov/idg/api/v1/targets(17282)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":585,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/properties"},"_links":{"count":1354,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/synonyms"},"_publications":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/publications"},"_namespace":null},{"id":17283,"version":2,"created":1554999482000,"modified":1554999488000,"deprecated":false,"name":"Very large A-kinase anchor protein","accession":"Q68DQ2","gene":"CRYBG3","description":"Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.249586974963567,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(17283)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/publications"},"_namespace":null},{"id":17284,"version":2,"created":1554999489000,"modified":1554999492000,"deprecated":false,"name":"Elongin BC and Polycomb repressive complex 2-associated protein","accession":"A6NHQ4","gene":"EPOP","description":"Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.31585376884443433,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.273809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.22847939532991027,"self":"https://pharos.nih.gov/idg/api/v1/targets(17284)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(17284)/properties"},"_links":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(17284)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(17284)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(17284)/publications"},"_namespace":null},{"id":17285,"version":3,"created":1554999492000,"modified":1555043895000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF6","accession":"Q9Y252","gene":"RNF6","description":"E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8707660985668774,"antibodyCount":192,"monoclonalCount":26,"pubmedCount":null,"jensenScore":9.729205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":40.73386390961712,"pubTatorScore":0.8314432015240787,"self":"https://pharos.nih.gov/idg/api/v1/targets(17285)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/publications"},"_namespace":null},{"id":17286,"version":2,"created":1554999499000,"modified":1554999507000,"deprecated":false,"name":"Granulocyte-macrophage colony-stimulating factor","accession":"P04141","gene":"CSF2","description":"Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.916819995870023,"antibodyCount":1272,"monoclonalCount":714,"pubmedCount":null,"jensenScore":8450.342257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.12387997061882,"pubTatorScore":3.9534431361487927,"self":"https://pharos.nih.gov/idg/api/v1/targets(17286)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/properties"},"_links":{"count":621,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/synonyms"},"_publications":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/publications"},"_namespace":null},{"id":17287,"version":3,"created":1554999509000,"modified":1555043896000,"deprecated":false,"name":"DNA polymerase eta","accession":"Q9Y253","gene":"POLH","description":"DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). 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Can utilize both NADH and NADPH.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4730007348241947,"antibodyCount":175,"monoclonalCount":21,"pubmedCount":null,"jensenScore":300.795929,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":30.596089710883156,"pubTatorScore":1.0668285213452848,"self":"https://pharos.nih.gov/idg/api/v1/targets(17294)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(17294)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(17294)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(17294)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17294)/publications"},"_namespace":null},{"id":17295,"version":2,"created":1554999557000,"modified":1554999562000,"deprecated":false,"name":"Secretion-regulating guanine nucleotide exchange factor","accession":"Q9UGK8","gene":"SERGEF","description":"Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.25823911397139193,"antibodyCount":71,"monoclonalCount":18,"pubmedCount":null,"jensenScore":2.117895,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.288493959639645,"pubTatorScore":0.3553877218534048,"self":"https://pharos.nih.gov/idg/api/v1/targets(17295)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(17295)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(17295)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(17295)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(17295)/publications"},"_namespace":null},{"id":17296,"version":3,"created":1554999563000,"modified":1555043904000,"deprecated":false,"name":"PRELI domain-containing protein 1, mitochondrial","accession":"Q9Y255","gene":"PRELID1","description":"Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. 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Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. 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Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability (PubMed:28738408, PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, MB21D1/cGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408, PubMed:28759889).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.65657368025251,"antibodyCount":126,"monoclonalCount":4,"pubmedCount":null,"jensenScore":428.170755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.4543703207952174,"self":"https://pharos.nih.gov/idg/api/v1/targets(17499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/publications"},"_namespace":null},{"id":17500,"version":2,"created":1555002667000,"modified":1555002671000,"deprecated":false,"name":"Zinc finger protein 614","accession":"Q8N883","gene":"ZNF614","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.146128035678238,"antibodyCount":102,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.63914900104766,"pubTatorScore":-1.1760890875887005,"self":"https://pharos.nih.gov/idg/api/v1/targets(17500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/properties"},"_links":{"count":817,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/publications"},"_namespace":null},{"id":17501,"version":2,"created":1555002671000,"modified":1555002675000,"deprecated":false,"name":"Heat shock 70 kDa protein 12B","accession":"Q96MM6","gene":"HSPA12B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9711432559447918,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.035587,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.589952076723335,"pubTatorScore":0.630088748857461,"self":"https://pharos.nih.gov/idg/api/v1/targets(17501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/publications"},"_namespace":null},{"id":17502,"version":2,"created":1555002676000,"modified":1555002680000,"deprecated":false,"name":"M-phase phosphoprotein 8","accession":"Q99549","gene":"MPHOSPH8","description":"Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). 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Mediates down-regulation of CDH1 expression (PubMed:20871592).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.166440982024961,"antibodyCount":58,"monoclonalCount":8,"pubmedCount":null,"jensenScore":15.546911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.721617991705386,"pubTatorScore":1.089652794273308,"self":"https://pharos.nih.gov/idg/api/v1/targets(17502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/publications"},"_namespace":null},{"id":17503,"version":3,"created":1555002680000,"modified":1555044036000,"deprecated":false,"name":"RNA-binding protein 4B","accession":"Q9BQ04","gene":"RBM4B","description":"Required for the translational activation of PER1 mRNA in response to circadian clock. 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Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. 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Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8075923005212315,"antibodyCount":220,"monoclonalCount":19,"pubmedCount":null,"jensenScore":80.275465,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.68267521837803,"pubTatorScore":1.7398363215807648,"self":"https://pharos.nih.gov/idg/api/v1/targets(17696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/publications"},"_namespace":null},{"id":17697,"version":2,"created":1555003843000,"modified":1555003844000,"deprecated":false,"name":"Serpin A11","accession":"Q86U17","gene":"SERPINA11","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.30234803816437344,"antibodyCount":64,"monoclonalCount":5,"pubmedCount":null,"jensenScore":0.526165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.91743369965142,"pubTatorScore":-0.3723863384943485,"self":"https://pharos.nih.gov/idg/api/v1/targets(17697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/properties"},"_links":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/publications"},"_namespace":null},{"id":17698,"version":2,"created":1555003844000,"modified":1555003849000,"deprecated":false,"name":"UDP-N-acetylglucosamine transporter","accession":"Q9Y2D2","gene":"SLC35A3","description":"Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.9294593821295687,"antibodyCount":50,"monoclonalCount":24,"pubmedCount":null,"jensenScore":75.305862,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.9538209710736,"pubTatorScore":1.0543576495492253,"self":"https://pharos.nih.gov/idg/api/v1/targets(17698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/publications"},"_namespace":null},{"id":17699,"version":2,"created":1555003849000,"modified":1555003856000,"deprecated":false,"name":"Afadin- and alpha-actinin-binding protein","accession":"Q9Y2D8","gene":"SSX2IP","description":"Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5666115208453306,"antibodyCount":120,"monoclonalCount":16,"pubmedCount":null,"jensenScore":37.647358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.742162472154256,"pubTatorScore":1.259370080742152,"self":"https://pharos.nih.gov/idg/api/v1/targets(17699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/publications"},"_namespace":null},{"id":17700,"version":2,"created":1555003856000,"modified":1555003861000,"deprecated":false,"name":"Zinc finger protein 652","accession":"Q9Y2D9","gene":"ZNF652","description":"Functions as a transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.704773344397246,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.207875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.23364702727637,"pubTatorScore":0.879079069626115,"self":"https://pharos.nih.gov/idg/api/v1/targets(17700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/publications"},"_namespace":null},{"id":17701,"version":3,"created":1555003862000,"modified":1555044165000,"deprecated":false,"name":"Voltage-dependent L-type calcium channel subunit beta-1","accession":"Q02641","gene":"CACNB1","description":"The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.9084067908137039,"antibodyCount":294,"monoclonalCount":56,"pubmedCount":null,"jensenScore":6.639103,"patentCount":6179,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":41.039275382887396,"pubTatorScore":0.9817518502084668,"self":"https://pharos.nih.gov/idg/api/v1/targets(17701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":496,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/publications"},"_namespace":null},{"id":17702,"version":2,"created":1555003867000,"modified":1555003871000,"deprecated":false,"name":"Exocyst complex component 6B","accession":"Q9Y2D4","gene":"EXOC6B","description":"Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7047223355413473,"antibodyCount":48,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.669814,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.648028595542876,"pubTatorScore":0.7229079844338242,"self":"https://pharos.nih.gov/idg/api/v1/targets(17702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/publications"},"_namespace":null},{"id":17703,"version":2,"created":1555003872000,"modified":1555003875000,"deprecated":false,"name":"A-kinase anchor protein 2","accession":"Q9Y2D5","gene":"PALM2-AKAP2","description":"Binds to regulatory subunit (RII) of protein kinase A. 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During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.467713790540776,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.494054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":27.201495818334394,"pubTatorScore":0.67843160252195,"self":"https://pharos.nih.gov/idg/api/v1/targets(17705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/publications"},"_namespace":null},{"id":17706,"version":2,"created":1555003888000,"modified":1555003892000,"deprecated":false,"name":"Protein broad-minded","accession":"Q96NH3","gene":"TBC1D32","description":"Required for high-level Shh responses in the developing neural tube. 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Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.4276358897689372,"antibodyCount":333,"monoclonalCount":124,"pubmedCount":null,"jensenScore":2.508889,"patentCount":1779,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.08881735048571,"pubTatorScore":0.9034517121861506,"self":"https://pharos.nih.gov/idg/api/v1/targets(17707)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/publications"},"_namespace":null},{"id":17708,"version":2,"created":1555003900000,"modified":1555003903000,"deprecated":false,"name":"Cytochrome b561 domain-containing protein 1","accession":"Q8N8Q1","gene":"CYB561D1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.027248706234293,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/publications"},"_namespace":null},{"id":17709,"version":3,"created":1555003904000,"modified":1555044168000,"deprecated":false,"name":"Claudin-10","accession":"P78369","gene":"CLDN10","description":"Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. 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Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). 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Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.7484518107084512,"antibodyCount":341,"monoclonalCount":48,"pubmedCount":null,"jensenScore":537.78783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.94561371241707,"pubTatorScore":2.527328548039641,"self":"https://pharos.nih.gov/idg/api/v1/targets(17796)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":513,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/synonyms"},"_publications":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/publications"},"_namespace":null},{"id":17797,"version":2,"created":1555005058000,"modified":1555005059000,"deprecated":false,"name":"Susceptibility protein NSG-x","accession":"Q9UH64","gene":"CDKN2A-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.507987092933577,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17797)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/publications"},"_namespace":null},{"id":17798,"version":3,"created":1555005059000,"modified":1555044221000,"deprecated":false,"name":"Sodium-coupled monocarboxylate transporter 2","accession":"Q1EHB4","gene":"SLC5A12","description":"Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. 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Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.6616101298882765,"antibodyCount":10,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.968243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.5830868881201,"pubTatorScore":0.45010231662026934,"self":"https://pharos.nih.gov/idg/api/v1/targets(17798)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/publications"},"_namespace":null},{"id":17799,"version":2,"created":1555005062000,"modified":1555005066000,"deprecated":false,"name":"Acyloxyacyl hydrolase","accession":"P28039","gene":"AOAH","description":"Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145). 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Involved in glucose-responsive gene regulation.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.383661045142752,"antibodyCount":265,"monoclonalCount":7,"pubmedCount":null,"jensenScore":2368.906221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":38.82789098840238,"pubTatorScore":1.4855411284660105,"self":"https://pharos.nih.gov/idg/api/v1/targets(17874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/publications"},"_namespace":null},{"id":17875,"version":3,"created":1555006094000,"modified":1555044287000,"deprecated":false,"name":"SUN domain-containing protein 2","accession":"Q9UH99","gene":"SUN2","description":"As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6625960523795016,"antibodyCount":114,"monoclonalCount":9,"pubmedCount":null,"jensenScore":38.416713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":41.945946102763656,"pubTatorScore":1.5045576447549451,"self":"https://pharos.nih.gov/idg/api/v1/targets(17875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/properties"},"_links":{"count":1212,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/publications"},"_namespace":null},{"id":17876,"version":2,"created":1555006100000,"modified":1555006105000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 5","accession":"P53041","gene":"PPP5C","description":"Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5907470714683236,"antibodyCount":338,"monoclonalCount":175,"pubmedCount":null,"jensenScore":41.938543,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.49084145994729,"pubTatorScore":2.039399951822782,"self":"https://pharos.nih.gov/idg/api/v1/targets(17876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/properties"},"_links":{"count":1063,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/links"},"_synonyms":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/publications"},"_namespace":null},{"id":17877,"version":3,"created":1555006107000,"modified":1555044289000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF43","accession":"Q68DV7","gene":"RNF43","description":"E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7004308192895656,"antibodyCount":115,"monoclonalCount":0,"pubmedCount":null,"jensenScore":55.03305,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":37.781423663965924,"pubTatorScore":1.54785483947469,"self":"https://pharos.nih.gov/idg/api/v1/targets(17877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/publications"},"_namespace":null},{"id":17878,"version":4,"created":1555006114000,"modified":1555044290000,"deprecated":false,"name":"Arachidonate 15-lipoxygenase","accession":"P16050","gene":"ALOX15","description":"Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.437723793733538,"antibodyCount":185,"monoclonalCount":68,"pubmedCount":null,"jensenScore":277.565109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.34952907975855,"pubTatorScore":2.73055456333208,"self":"https://pharos.nih.gov/idg/api/v1/targets(17878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":540,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/properties"},"_links":{"count":1140,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/synonyms"},"_publications":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/publications"},"_namespace":null},{"id":17879,"version":2,"created":1555006173000,"modified":1555006175000,"deprecated":false,"name":"Protein FAM92A","accession":"A1XBS5","gene":"FAM92A","description":"May play a role in ciliogenesis (PubMed:27528616). 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In addition, may also function as scaffolding protein (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1133310814461512,"antibodyCount":435,"monoclonalCount":84,"pubmedCount":null,"jensenScore":124.397291,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":54.65783103369844,"pubTatorScore":1.632601992409748,"self":"https://pharos.nih.gov/idg/api/v1/targets(17880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":567,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/properties"},"_links":{"count":1290,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/synonyms"},"_publications":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/publications"},"_namespace":null},{"id":17881,"version":3,"created":1555006185000,"modified":1555044294000,"deprecated":false,"name":"Protein PAT1 homolog 1","accession":"Q86TB9","gene":"PATL1","description":"RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8114260395773512,"antibodyCount":65,"monoclonalCount":1,"pubmedCount":null,"jensenScore":7.84267,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.17065984534335,"pubTatorScore":0.8912320619274487,"self":"https://pharos.nih.gov/idg/api/v1/targets(17881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/publications"},"_namespace":null},{"id":17882,"version":3,"created":1555006192000,"modified":1555044295000,"deprecated":false,"name":"cAMP-dependent protein kinase inhibitor gamma","accession":"Q9Y2B9","gene":"PKIG","description":"Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8196222554530482,"antibodyCount":29,"monoclonalCount":7,"pubmedCount":null,"jensenScore":8.099626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.097041253098254,"pubTatorScore":0.7781512503836436,"self":"https://pharos.nih.gov/idg/api/v1/targets(17882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/publications"},"_namespace":null},{"id":17883,"version":2,"created":1555006197000,"modified":1555006197000,"deprecated":false,"name":"Early placenta insulin-like peptide","accession":"Q14641","gene":"INSL4","description":"May play an important role in trophoblast development and in the regulation of bone formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4238628277087269,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":28.672542,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.400550318524594,"pubTatorScore":1.4028464858979066,"self":"https://pharos.nih.gov/idg/api/v1/targets(17883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/properties"},"_links":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/publications"},"_namespace":null},{"id":17884,"version":2,"created":1555006197000,"modified":1555006201000,"deprecated":false,"name":"Polyadenylate-binding protein 4","accession":"Q13310","gene":"PABPC4","description":"Binds the poly(A) tail of mRNA. 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Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhbits endoderm differentiation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2802876293802856,"antibodyCount":350,"monoclonalCount":98,"pubmedCount":null,"jensenScore":205.072108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":50.87528359069619,"pubTatorScore":2.296084789162556,"self":"https://pharos.nih.gov/idg/api/v1/targets(17942)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/synonyms"},"_publications":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/publications"},"_namespace":null},{"id":17943,"version":2,"created":1555006609000,"modified":1555006613000,"deprecated":false,"name":"Protein KIAA0100","accession":"Q14667","gene":"KIAA0100","description":"May be involved in membrane trafficking.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9336559949435908,"antibodyCount":31,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.190476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.18375792586479,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(17943)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/publications"},"_namespace":null},{"id":17944,"version":2,"created":1555006614000,"modified":1555006619000,"deprecated":false,"name":"Pro-neuregulin-3, membrane-bound isoform","accession":"P56975","gene":"NRG3","description":"Direct ligand for the ERBB4 tyrosine kinase receptor. 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May also play a role in transmembrane water transport, possibly by indirect means.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.0715764930789526,"antibodyCount":101,"monoclonalCount":20,"pubmedCount":null,"jensenScore":116.948898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.25238289892423,"pubTatorScore":2.1203083348647773,"self":"https://pharos.nih.gov/idg/api/v1/targets(17945)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/publications"},"_namespace":null},{"id":17946,"version":2,"created":1555006628000,"modified":1555006631000,"deprecated":false,"name":"Zinc finger protein 626","accession":"Q68DY1","gene":"ZNF626","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.69335280954592,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17946)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/publications"},"_namespace":null},{"id":17947,"version":3,"created":1555006631000,"modified":1555044348000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DM beta chain","accession":"P28068","gene":"HLA-DMB","description":"Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. 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Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2091745916372774,"antibodyCount":64,"monoclonalCount":3,"pubmedCount":null,"jensenScore":177.867888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.308848489580637,"pubTatorScore":2.5766573347939437,"self":"https://pharos.nih.gov/idg/api/v1/targets(17948)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/properties"},"_links":{"count":742,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/synonyms"},"_publications":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/publications"},"_namespace":null},{"id":17949,"version":3,"created":1555006643000,"modified":1555044350000,"deprecated":false,"name":"Proteasome subunit alpha type-5","accession":"P28066","gene":"PSMA5","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1667569840073957,"antibodyCount":307,"monoclonalCount":73,"pubmedCount":null,"jensenScore":13.438209,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":45.7644952803287,"pubTatorScore":1.0492722673163284,"self":"https://pharos.nih.gov/idg/api/v1/targets(17949)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":633,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/properties"},"_links":{"count":1243,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/links"},"_synonyms":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/publications"},"_namespace":null},{"id":17950,"version":3,"created":1555006652000,"modified":1555044352000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DM alpha chain","accession":"P28067","gene":"HLA-DMA","description":"Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. 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Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1372772376284166,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":136.273898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.237591176520425,"pubTatorScore":1.2168253969052283,"self":"https://pharos.nih.gov/idg/api/v1/targets(17951)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/publications"},"_namespace":null},{"id":17952,"version":3,"created":1555006664000,"modified":1555044355000,"deprecated":false,"name":"Proteasome subunit beta type-9","accession":"P28065","gene":"PSMB9","description":"The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. 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May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5928250216022373,"antibodyCount":257,"monoclonalCount":93,"pubmedCount":null,"jensenScore":384.926598,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.101236574732276,"pubTatorScore":2.288439195680316,"self":"https://pharos.nih.gov/idg/api/v1/targets(17961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/publications"},"_namespace":null},{"id":17962,"version":2,"created":1555006731000,"modified":1555006733000,"deprecated":false,"name":"Homeobox protein Hox-A4","accession":"Q00056","gene":"HOXA4","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. 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May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.902021201592069,"antibodyCount":496,"monoclonalCount":106,"pubmedCount":null,"jensenScore":763.926091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.26551678362893,"pubTatorScore":2.64234344204775,"self":"https://pharos.nih.gov/idg/api/v1/targets(17969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":532,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/synonyms"},"_publications":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/publications"},"_namespace":null},{"id":17970,"version":2,"created":1555006824000,"modified":1555006827000,"deprecated":false,"name":"Potassium channel subfamily K member 12","accession":"Q9HB15","gene":"KCNK12","description":"Probable potassium channel subunit. 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May need to associate with another protein to form a functional channel (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.7461220797215813,"antibodyCount":102,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.030795,"patentCount":496,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.865569546333365,"pubTatorScore":0.8160186587229207,"self":"https://pharos.nih.gov/idg/api/v1/targets(17970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/properties"},"_links":{"count":686,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/publications"},"_namespace":null},{"id":17971,"version":2,"created":1555006828000,"modified":1555006833000,"deprecated":false,"name":"Nuclear body protein SP140","accession":"Q13342","gene":"SP140","description":"Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-1.1243837734616466,"antibodyCount":114,"monoclonalCount":22,"pubmedCount":null,"jensenScore":14.162196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.890065610984415,"pubTatorScore":1.0377584270451916,"self":"https://pharos.nih.gov/idg/api/v1/targets(17971)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/publications"},"_namespace":null},{"id":17972,"version":3,"created":1555006833000,"modified":1555044365000,"deprecated":false,"name":"Separin","accession":"Q14674","gene":"ESPL1","description":"Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4159504798042266,"antibodyCount":535,"monoclonalCount":73,"pubmedCount":null,"jensenScore":262.856135,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.78208066931231,"pubTatorScore":2.080726669699952,"self":"https://pharos.nih.gov/idg/api/v1/targets(17972)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/publications"},"_namespace":null},{"id":17973,"version":3,"created":1555006842000,"modified":1555044366000,"deprecated":false,"name":"Methylosome protein 50","accession":"Q9BQA1","gene":"WDR77","description":"Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3811139482884653,"antibodyCount":163,"monoclonalCount":80,"pubmedCount":null,"jensenScore":24.700696,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":40.75046679924489,"pubTatorScore":1.2257314795256935,"self":"https://pharos.nih.gov/idg/api/v1/targets(17973)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/publications"},"_namespace":null},{"id":17974,"version":2,"created":1555006846000,"modified":1555006850000,"deprecated":false,"name":"MLX-interacting protein","accession":"Q9HAP2","gene":"MLXIP","description":"Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1610718622729959,"antibodyCount":101,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.509522,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.190388000595625,"pubTatorScore":2.0164937190197545,"self":"https://pharos.nih.gov/idg/api/v1/targets(17974)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/publications"},"_namespace":null},{"id":17975,"version":3,"created":1555006851000,"modified":1555044368000,"deprecated":false,"name":"Pumilio homolog 1","accession":"Q14671","gene":"PUM1","description":"Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4087092846402554,"antibodyCount":198,"monoclonalCount":8,"pubmedCount":null,"jensenScore":23.627815,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.9832565753904,"pubTatorScore":1.416536929897623,"self":"https://pharos.nih.gov/idg/api/v1/targets(17975)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/publications"},"_namespace":null},{"id":17976,"version":2,"created":1555006857000,"modified":1555006861000,"deprecated":false,"name":"Homeobox protein Nkx-2.1","accession":"P43699","gene":"NKX2-1","description":"Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.086313276801531,"antibodyCount":530,"monoclonalCount":328,"pubmedCount":null,"jensenScore":1272.525821,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.82426035853863,"pubTatorScore":2.7959002244224904,"self":"https://pharos.nih.gov/idg/api/v1/targets(17976)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":500,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/synonyms"},"_publications":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/publications"},"_namespace":null},{"id":17977,"version":2,"created":1555006862000,"modified":1555006867000,"deprecated":false,"name":"NAD kinase","accession":"O95544","gene":"NADK","description":null,"idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.4988026623086184,"antibodyCount":98,"monoclonalCount":7,"pubmedCount":null,"jensenScore":29.788294,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.58195033064426,"pubTatorScore":1.7016159361174552,"self":"https://pharos.nih.gov/idg/api/v1/targets(17977)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/publications"},"_namespace":null},{"id":17978,"version":2,"created":1555006868000,"modified":1555006874000,"deprecated":false,"name":"KN motif and ankyrin repeat domain-containing protein 1","accession":"Q14678","gene":"KANK1","description":"Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5212151135298895,"antibodyCount":64,"monoclonalCount":21,"pubmedCount":null,"jensenScore":36.613596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.04749073516603,"pubTatorScore":1.3598963551603385,"self":"https://pharos.nih.gov/idg/api/v1/targets(17978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/publications"},"_namespace":null},{"id":17979,"version":3,"created":1555006875000,"modified":1555044369000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit I","accession":"Q13347","gene":"EIF3I","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0725739933368414,"antibodyCount":118,"monoclonalCount":27,"pubmedCount":null,"jensenScore":13.98511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":39.29790553627566,"pubTatorScore":1.3819049404864894,"self":"https://pharos.nih.gov/idg/api/v1/targets(17979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/publications"},"_namespace":null},{"id":17980,"version":3,"created":1555006880000,"modified":1555044371000,"deprecated":false,"name":"Clathrin interactor 1","accession":"Q14677","gene":"CLINT1","description":"Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2666775220042608,"antibodyCount":151,"monoclonalCount":39,"pubmedCount":null,"jensenScore":179.415926,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":40.945466768159505,"pubTatorScore":1.6448994749676544,"self":"https://pharos.nih.gov/idg/api/v1/targets(17980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":427,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/properties"},"_links":{"count":1215,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/publications"},"_namespace":null},{"id":17981,"version":3,"created":1555006887000,"modified":1555044373000,"deprecated":false,"name":"Mediator of DNA damage checkpoint protein 1","accession":"Q14676","gene":"MDC1","description":"Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.127625760298927,"antibodyCount":286,"monoclonalCount":95,"pubmedCount":null,"jensenScore":136.368463,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.6772211269631,"pubTatorScore":2.1291903564507138,"self":"https://pharos.nih.gov/idg/api/v1/targets(17981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":549,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/links"},"_synonyms":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/publications"},"_namespace":null},{"id":17982,"version":2,"created":1555006894000,"modified":1555006899000,"deprecated":false,"name":"Tubulin polyglutamylase TTLL4","accession":"Q14679","gene":"TTLL4","description":"Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5232842181139135,"antibodyCount":111,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.238505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.913826434907634,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(17982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/publications"},"_namespace":null},{"id":17983,"version":2,"created":1555006900000,"modified":1555006904000,"deprecated":false,"name":"Integrin alpha-D","accession":"Q13349","gene":"ITGAD","description":"Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4350439901113152,"antibodyCount":63,"monoclonalCount":22,"pubmedCount":null,"jensenScore":29.648189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.094822692117802,"pubTatorScore":1.2430167305082267,"self":"https://pharos.nih.gov/idg/api/v1/targets(17983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/publications"},"_namespace":null},{"id":17984,"version":4,"created":1555006905000,"modified":1555044374000,"deprecated":false,"name":"Proteasome subunit beta type-5","accession":"P28074","gene":"PSMB5","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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May contribute to cancer pathogenesis by promoting tumor cell migration.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.606999849775019,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.568854,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":31.780429467567895,"pubTatorScore":1.2436285357410788,"self":"https://pharos.nih.gov/idg/api/v1/targets(18203)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/publications"},"_namespace":null},{"id":18204,"version":2,"created":1555009835000,"modified":1555009862000,"deprecated":false,"name":"Tyrosine-protein kinase receptor UFO","accession":"P30530","gene":"AXL","description":"(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.699691532209938,"antibodyCount":756,"monoclonalCount":198,"pubmedCount":null,"jensenScore":528.131087,"patentCount":74117,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.71998517470335,"pubTatorScore":2.717148052096508,"self":"https://pharos.nih.gov/idg/api/v1/targets(18204)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/properties"},"_links":{"count":1242,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/synonyms"},"_publications":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/publications"},"_namespace":null},{"id":18205,"version":3,"created":1555009863000,"modified":1555044515000,"deprecated":false,"name":"Sodium- and chloride-dependent GABA transporter 1","accession":"P30531","gene":"SLC6A1","description":"Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.","idgFamily":"Transporter","idgTDL":"Tclin","novelty":-2.9100984194244015,"antibodyCount":172,"monoclonalCount":3,"pubmedCount":null,"jensenScore":786.693194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":36.4932010713642,"pubTatorScore":2.284965448565487,"self":"https://pharos.nih.gov/idg/api/v1/targets(18205)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/publications"},"_namespace":null},{"id":18206,"version":3,"created":1555009893000,"modified":1555044517000,"deprecated":false,"name":"Heme-binding protein 1","accession":"Q9NRV9","gene":"HEBP1","description":"May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.027912464053539,"antibodyCount":132,"monoclonalCount":4,"pubmedCount":null,"jensenScore":107.488237,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.52123605005585,"pubTatorScore":2.4017299935996554,"self":"https://pharos.nih.gov/idg/api/v1/targets(18206)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/publications"},"_namespace":null},{"id":18207,"version":3,"created":1555009898000,"modified":1555044518000,"deprecated":false,"name":"Neuronal acetylcholine receptor subunit alpha-5","accession":"P30532","gene":"CHRNA5","description":"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.1557453095945154,"antibodyCount":237,"monoclonalCount":14,"pubmedCount":null,"jensenScore":143.069778,"patentCount":2140,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.57817555643266,"pubTatorScore":2.1689731142671036,"self":"https://pharos.nih.gov/idg/api/v1/targets(18207)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":497,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/synonyms"},"_publications":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/publications"},"_namespace":null},{"id":18208,"version":2,"created":1555009906000,"modified":1555009911000,"deprecated":false,"name":"Apolipoprotein L domain-containing protein 1","accession":"Q96LR9","gene":"APOLD1","description":"May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":64,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.08119898627755,"pubTatorScore":1.2428311759823414,"self":"https://pharos.nih.gov/idg/api/v1/targets(18208)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/publications"},"_namespace":null},{"id":18209,"version":2,"created":1555009912000,"modified":1555009917000,"deprecated":false,"name":"AT-rich interactive domain-containing protein 2","accession":"Q68CP9","gene":"ARID2","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.324901944178325,"antibodyCount":71,"monoclonalCount":24,"pubmedCount":null,"jensenScore":22.02128,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.82119772235735,"pubTatorScore":2.3486617259288165,"self":"https://pharos.nih.gov/idg/api/v1/targets(18209)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/publications"},"_namespace":null},{"id":18210,"version":3,"created":1555009918000,"modified":1555044520000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 E2","accession":"Q96LR5","gene":"UBE2E2","description":"Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.417444639671184,"antibodyCount":130,"monoclonalCount":10,"pubmedCount":null,"jensenScore":21.840982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.62071125756205,"pubTatorScore":1.1808333076837243,"self":"https://pharos.nih.gov/idg/api/v1/targets(18210)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/publications"},"_namespace":null},{"id":18211,"version":2,"created":1555009924000,"modified":1555009925000,"deprecated":false,"name":"Uncharacterized protein C3orf30","accession":"Q96M34","gene":"C3orf30","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(18211)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/properties"},"_links":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/publications"},"_namespace":null},{"id":18212,"version":3,"created":1555009926000,"modified":1555044523000,"deprecated":false,"name":"Protein FAM19A4","accession":"Q96LR4","gene":"FAM19A4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0574950014469144,"antibodyCount":57,"monoclonalCount":18,"pubmedCount":null,"jensenScore":9.336642,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":50,"knowledgeAvailability":18.719699279479414,"pubTatorScore":0.8709571319039024,"self":"https://pharos.nih.gov/idg/api/v1/targets(18212)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/properties"},"_links":{"count":489,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/publications"},"_namespace":null},{"id":18213,"version":3,"created":1555009929000,"modified":1555044524000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RING2","accession":"Q99496","gene":"RNF2","description":"E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0452491810528186,"antibodyCount":332,"monoclonalCount":160,"pubmedCount":null,"jensenScore":115.682553,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.87390402399221,"pubTatorScore":2.2729835941813636,"self":"https://pharos.nih.gov/idg/api/v1/targets(18213)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/publications"},"_namespace":null},{"id":18214,"version":3,"created":1555009934000,"modified":1555044525000,"deprecated":false,"name":"Uncharacterized protein C2orf50","accession":"Q96LR7","gene":"C2orf50","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18214)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/properties"},"_links":{"count":648,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/publications"},"_namespace":null},{"id":18215,"version":2,"created":1555009937000,"modified":1555009942000,"deprecated":false,"name":"Protein/nucleic acid deglycase DJ-1","accession":"Q99497","gene":"PARK7","description":"Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity (PubMed:22523093). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785, PubMed:26995087). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.892613634046932,"antibodyCount":625,"monoclonalCount":111,"pubmedCount":null,"jensenScore":835.460014,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.309912432192384,"pubTatorScore":2.7642441774915003,"self":"https://pharos.nih.gov/idg/api/v1/targets(18215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/properties"},"_links":{"count":1516,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/links"},"_synonyms":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/synonyms"},"_publications":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/publications"},"_namespace":null},{"id":18216,"version":2,"created":1555009945000,"modified":1555009956000,"deprecated":false,"name":"Protein S100-B","accession":"P04271","gene":"S100B","description":"Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.488932542289977,"antibodyCount":903,"monoclonalCount":518,"pubmedCount":null,"jensenScore":3193.151212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.417841114860174,"pubTatorScore":3.728039669647618,"self":"https://pharos.nih.gov/idg/api/v1/targets(18216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/synonyms"},"_publications":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/publications"},"_namespace":null},{"id":18217,"version":2,"created":1555009959000,"modified":1555009962000,"deprecated":false,"name":"Protein SPT2 homolog","accession":"Q68D10","gene":"SPTY2D1","description":"Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). 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Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. 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In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(18260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2679,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/properties"},"_links":{"count":1110,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/synonyms"},"_publications":{"count":2540,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/publications"},"_namespace":null},{"id":18261,"version":2,"created":1555010333000,"modified":1555010336000,"deprecated":false,"name":"Stress-associated endoplasmic reticulum protein 2","accession":"Q8N6R1","gene":"SERP2","description":"May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. 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Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.7284836554883687,"antibodyCount":1063,"monoclonalCount":315,"pubmedCount":null,"jensenScore":9058.642958,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":3.791443935403016,"self":"https://pharos.nih.gov/idg/api/v1/targets(18263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2451,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/properties"},"_links":{"count":2940,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/synonyms"},"_publications":{"count":2032,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/publications"},"_namespace":null},{"id":18264,"version":2,"created":1555010372000,"modified":1555010376000,"deprecated":false,"name":"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4","accession":"Q9C0J1","gene":"B3GNT4","description":"Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. 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The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4095828627958213,"antibodyCount":48,"monoclonalCount":6,"pubmedCount":null,"jensenScore":276.022785,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":25.836502608472706,"pubTatorScore":0.24303804868629444,"self":"https://pharos.nih.gov/idg/api/v1/targets(18326)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/properties"},"_links":{"count":707,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/publications"},"_namespace":null},{"id":18327,"version":3,"created":1555010643000,"modified":1555044594000,"deprecated":false,"name":"Sodium channel subunit beta-2","accession":"O60939","gene":"SCN2B","description":"Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.298420618101245,"antibodyCount":156,"monoclonalCount":47,"pubmedCount":null,"jensenScore":17.129689,"patentCount":1912,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":58,"knowledgeAvailability":29.906409553429153,"pubTatorScore":1.031054582206085,"self":"https://pharos.nih.gov/idg/api/v1/targets(18327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/publications"},"_namespace":null},{"id":18328,"version":3,"created":1555010648000,"modified":1555044596000,"deprecated":false,"name":"Uncharacterized protein encoded by LINC01587","accession":"Q99440","gene":"LINC01587","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.07918124778480276,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":9.7816240844167,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(18328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/publications"},"_namespace":null},{"id":18329,"version":2,"created":1555010649000,"modified":1555010655000,"deprecated":false,"name":"Meckelin","accession":"Q5HYA8","gene":"TMEM67","description":"Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5295383493835482,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":36.32789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.0460623261669,"pubTatorScore":1.4396354100024937,"self":"https://pharos.nih.gov/idg/api/v1/targets(18329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/publications"},"_namespace":null},{"id":18330,"version":3,"created":1555010656000,"modified":1555044596000,"deprecated":false,"name":"Aldo-keto reductase family 1 member C4","accession":"P17516","gene":"AKR1C4","description":"Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). 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The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7014776807362353,"antibodyCount":221,"monoclonalCount":24,"pubmedCount":null,"jensenScore":51.386621,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.987767509545932,"pubTatorScore":2.437607501043699,"self":"https://pharos.nih.gov/idg/api/v1/targets(18330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/properties"},"_links":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/publications"},"_namespace":null},{"id":18331,"version":3,"created":1555010659000,"modified":1555044598000,"deprecated":false,"name":"Keratocan","accession":"O60938","gene":"KERA","description":"May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.227980643983189,"antibodyCount":105,"monoclonalCount":5,"pubmedCount":null,"jensenScore":161.279357,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":26.233469263490242,"pubTatorScore":1.6509209993764413,"self":"https://pharos.nih.gov/idg/api/v1/targets(18331)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/properties"},"_links":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/publications"},"_namespace":null},{"id":18332,"version":3,"created":1555010663000,"modified":1555044599000,"deprecated":false,"name":"Cyclic AMP-dependent transcription factor ATF-6 alpha","accession":"P18850","gene":"ATF6","description":"Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.6539092464103553,"antibodyCount":407,"monoclonalCount":86,"pubmedCount":null,"jensenScore":415.009105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.420857936834445,"pubTatorScore":2.3106378507772116,"self":"https://pharos.nih.gov/idg/api/v1/targets(18332)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/publications"},"_namespace":null},{"id":18333,"version":2,"created":1555010670000,"modified":1555010674000,"deprecated":false,"name":"Nucleolar protein 3","accession":"O60936","gene":"NOL3","description":"Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3220400983758633,"antibodyCount":271,"monoclonalCount":12,"pubmedCount":null,"jensenScore":197.586715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.59353569947662,"pubTatorScore":1.6359352386283572,"self":"https://pharos.nih.gov/idg/api/v1/targets(18333)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/publications"},"_namespace":null},{"id":18334,"version":3,"created":1555010675000,"modified":1555044600000,"deprecated":false,"name":"Nibrin","accession":"O60934","gene":"NBN","description":"Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. 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Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7854896804497282,"antibodyCount":197,"monoclonalCount":1,"pubmedCount":null,"jensenScore":62.435703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.75428609993083,"pubTatorScore":1.7299564283079218,"self":"https://pharos.nih.gov/idg/api/v1/targets(18701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/publications"},"_namespace":null},{"id":18702,"version":3,"created":1555013370000,"modified":1555014527000,"deprecated":false,"name":"Sodium channel protein type 9 subunit alpha","accession":"Q15858","gene":"SCN9A","description":"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.5799385805387294,"antibodyCount":327,"monoclonalCount":132,"pubmedCount":null,"jensenScore":379.245669,"patentCount":40955,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.212877968475794,"pubTatorScore":2.4968246052614376,"self":"https://pharos.nih.gov/idg/api/v1/targets(18702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/properties"},"_links":{"count":4120,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/publications"},"_namespace":null},{"id":18703,"version":2,"created":1555014535000,"modified":1555014540000,"deprecated":false,"name":"Hypermethylated in cancer 1 protein","accession":"Q14526","gene":"HIC1","description":"Transcriptional repressor. 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Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9730089860968754,"antibodyCount":199,"monoclonalCount":59,"pubmedCount":null,"jensenScore":106.971773,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.52030189083238,"pubTatorScore":1.960328155213801,"self":"https://pharos.nih.gov/idg/api/v1/targets(18703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/publications"},"_namespace":null},{"id":18704,"version":2,"created":1555014541000,"modified":1555014545000,"deprecated":false,"name":"Espin","accession":"B1AK53","gene":"ESPN","description":"Multifunctional actin-bundling protein. 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In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0142547710689915,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":100.360634,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.278437712646074,"pubTatorScore":1.414973347970818,"self":"https://pharos.nih.gov/idg/api/v1/targets(18704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/publications"},"_namespace":null},{"id":18705,"version":2,"created":1555014546000,"modified":1555014546000,"deprecated":false,"name":"Protein GVQW1","accession":"Q8N7I0","gene":"GVQW1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.517595389174526,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/properties"},"_links":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/publications"},"_namespace":null},{"id":18706,"version":2,"created":1555014546000,"modified":1555014549000,"deprecated":false,"name":"Keratin, type I cuticular Ha3-II","accession":"Q14525","gene":"KRT33B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.08218675455874577,"antibodyCount":116,"monoclonalCount":17,"pubmedCount":null,"jensenScore":1.020238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.46638037108637,"pubTatorScore":0.24783682248309327,"self":"https://pharos.nih.gov/idg/api/v1/targets(18706)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/properties"},"_links":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/publications"},"_namespace":null},{"id":18707,"version":2,"created":1555014549000,"modified":1555014552000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 23","accession":"Q86SG2","gene":"ANKRD23","description":"May be involved in the energy metabolism. 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Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.017679006901829,"antibodyCount":493,"monoclonalCount":234,"pubmedCount":null,"jensenScore":1049.914017,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":56.321459406769,"pubTatorScore":2.9068025037375302,"self":"https://pharos.nih.gov/idg/api/v1/targets(18708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/properties"},"_links":{"count":1246,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/synonyms"},"_publications":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/publications"},"_namespace":null},{"id":18709,"version":2,"created":1555014564000,"modified":1555014570000,"deprecated":false,"name":"Aquaporin-2","accession":"P41181","gene":"AQP2","description":"Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9532785776326125,"antibodyCount":394,"monoclonalCount":2,"pubmedCount":null,"jensenScore":957.656545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.63711835997627,"pubTatorScore":2.6570212485395417,"self":"https://pharos.nih.gov/idg/api/v1/targets(18709)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/synonyms"},"_publications":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/publications"},"_namespace":null},{"id":18710,"version":3,"created":1555014571000,"modified":1555014618000,"deprecated":false,"name":"Extracellular calcium-sensing receptor","accession":"P41180","gene":"CASR","description":"G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-3.221812559917414,"antibodyCount":441,"monoclonalCount":93,"pubmedCount":null,"jensenScore":1714.86889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.16744580763855,"pubTatorScore":2.9421124046747655,"self":"https://pharos.nih.gov/idg/api/v1/targets(18710)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/synonyms"},"_publications":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/publications"},"_namespace":null},{"id":18711,"version":3,"created":1555014620000,"modified":1555044802000,"deprecated":false,"name":"Lysozyme g-like protein 2","accession":"Q86SG7","gene":"LYG2","description":"May act as a potent antibacterial protein that may play a role in the innate immunity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7243113303243157,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.868066,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":11.984503717849064,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(18711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/properties"},"_links":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/publications"},"_namespace":null},{"id":18712,"version":2,"created":1555014622000,"modified":1555014626000,"deprecated":false,"name":"Serine/threonine-protein kinase Nek8","accession":"Q86SG6","gene":"NEK8","description":"Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.7153599528226902,"antibodyCount":225,"monoclonalCount":2,"pubmedCount":null,"jensenScore":50.895025,"patentCount":2833,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.065117638755765,"pubTatorScore":1.4435917686635487,"self":"https://pharos.nih.gov/idg/api/v1/targets(18712)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/publications"},"_namespace":null},{"id":18713,"version":2,"created":1555014626000,"modified":1555014629000,"deprecated":false,"name":"Protein S100-A7A","accession":"Q86SG5","gene":"S100A7A","description":"May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.550592405069908,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.377182,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.906574991773041,"pubTatorScore":1.150866027841494,"self":"https://pharos.nih.gov/idg/api/v1/targets(18713)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/properties"},"_links":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/publications"},"_namespace":null},{"id":18714,"version":2,"created":1555014629000,"modified":1555014629000,"deprecated":false,"name":"Putative Dresden prostate carcinoma protein 2","accession":"Q86SG4","gene":"HMGN2P46","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.470705601759493,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(18714)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/publications"},"_namespace":null},{"id":18715,"version":2,"created":1555014629000,"modified":1555014630000,"deprecated":false,"name":"Deleted in azoospermia protein 4","accession":"Q86SG3","gene":"DAZ4","description":"RNA-binding protein that plays an essential role in spermatogenesis. 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In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). 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Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.261628568384184,"antibodyCount":396,"monoclonalCount":42,"pubmedCount":null,"jensenScore":204.776368,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.38581343697828,"pubTatorScore":2.53662591709725,"self":"https://pharos.nih.gov/idg/api/v1/targets(18799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":542,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/properties"},"_links":{"count":1161,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/links"},"_synonyms":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/publications"},"_namespace":null},{"id":18800,"version":2,"created":1555016006000,"modified":1555016007000,"deprecated":false,"name":"Cis-aconitate decarboxylase","accession":"A6NK06","gene":"ACOD1","description":"Involved in the inhibition of the inflammatory response. 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Plays a role in the embryo implantation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7927661867042421,"antibodyCount":53,"monoclonalCount":1,"pubmedCount":null,"jensenScore":60.220555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.1601731614744817,"self":"https://pharos.nih.gov/idg/api/v1/targets(18800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/properties"},"_links":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/publications"},"_namespace":null},{"id":18801,"version":2,"created":1555016007000,"modified":1555016014000,"deprecated":false,"name":"Sushi repeat-containing protein SRPX2","accession":"O60687","gene":"SRPX2","description":"Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive 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fibroblasts.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5663813716630508,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.778461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":33.0716466889752,"pubTatorScore":0.5720967291742244,"self":"https://pharos.nih.gov/idg/api/v1/targets(18803)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/publications"},"_namespace":null},{"id":18804,"version":2,"created":1555016023000,"modified":1555016025000,"deprecated":false,"name":"Inactive ubiquitin carboxyl-terminal hydrolase 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Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":121,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.608787508454643,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/publications"},"_namespace":null},{"id":18807,"version":2,"created":1555016035000,"modified":1555016039000,"deprecated":false,"name":"Inactive ubiquitin carboxyl-terminal hydrolase 54","accession":"Q70EL1","gene":"USP54","description":"Has no peptidase activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.44314440358119517,"antibodyCount":31,"monoclonalCount":15,"pubmedCount":null,"jensenScore":2.905928,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.67412746639529,"pubTatorScore":0.05115252244738129,"self":"https://pharos.nih.gov/idg/api/v1/targets(18807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/publications"},"_namespace":null},{"id":18808,"version":3,"created":1555016039000,"modified":1555044878000,"deprecated":false,"name":"Male-specific lethal 3 homolog","accession":"Q8N5Y2","gene":"MSL3","description":"May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.0844627742703725,"antibodyCount":108,"monoclonalCount":3,"pubmedCount":null,"jensenScore":10.725535,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.34277617968513,"pubTatorScore":0.8234431231813019,"self":"https://pharos.nih.gov/idg/api/v1/targets(18808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/publications"},"_namespace":null},{"id":18809,"version":3,"created":1555016045000,"modified":1555044879000,"deprecated":false,"name":"Peroxisome biogenesis factor 10","accession":"O60683","gene":"PEX10","description":"Somewhat implicated in the biogenesis of peroxisomes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.413446112536443,"antibodyCount":102,"monoclonalCount":12,"pubmedCount":null,"jensenScore":23.786626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.66822226150113,"pubTatorScore":1.2875884703286289,"self":"https://pharos.nih.gov/idg/api/v1/targets(18809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/publications"},"_namespace":null},{"id":18810,"version":2,"created":1555016052000,"modified":1555016059000,"deprecated":false,"name":"Importin subunit alpha-7","accession":"O60684","gene":"KPNA6","description":"Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8928062488395216,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.132333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.66851860552836,"pubTatorScore":0.5563025007672873,"self":"https://pharos.nih.gov/idg/api/v1/targets(18810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/publications"},"_namespace":null},{"id":18811,"version":2,"created":1555016060000,"modified":1555016063000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 45","accession":"Q70EL2","gene":"USP45","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2955671119055774,"antibodyCount":115,"monoclonalCount":9,"pubmedCount":null,"jensenScore":18.665186,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.479658573756204,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(18811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/properties"},"_links":{"count":842,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/publications"},"_namespace":null},{"id":18812,"version":2,"created":1555016064000,"modified":1555016069000,"deprecated":false,"name":"Musculin","accession":"O60682","gene":"MSC","description":"Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.184019354901649,"antibodyCount":184,"monoclonalCount":15,"pubmedCount":null,"jensenScore":156.411403,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.74587356438918,"pubTatorScore":2.149884124119838,"self":"https://pharos.nih.gov/idg/api/v1/targets(18812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/publications"},"_namespace":null},{"id":18813,"version":2,"created":1555016069000,"modified":1555016077000,"deprecated":false,"name":"CUGBP Elav-like family member 2","accession":"O95319","gene":"CELF2","description":"RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.630423123000801,"antibodyCount":171,"monoclonalCount":7,"pubmedCount":null,"jensenScore":43.067094,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.46813556981579,"pubTatorScore":1.5450536050566357,"self":"https://pharos.nih.gov/idg/api/v1/targets(18813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/publications"},"_namespace":null},{"id":18814,"version":3,"created":1555016078000,"modified":1555044881000,"deprecated":false,"name":"Mono [ADP-ribose] polymerase PARP16","accession":"Q8N5Y8","gene":"PARP16","description":"Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). 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During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.8468073079434304,"antibodyCount":212,"monoclonalCount":76,"pubmedCount":null,"jensenScore":686.800384,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.728198903204333,"pubTatorScore":2.2090988119962884,"self":"https://pharos.nih.gov/idg/api/v1/targets(18903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/properties"},"_links":{"count":684,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/publications"},"_namespace":null},{"id":18904,"version":3,"created":1555017773000,"modified":1555044917000,"deprecated":false,"name":"Interleukin-1 receptor antagonist protein","accession":"P18510","gene":"IL1RN","description":"Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.102664368609459,"antibodyCount":604,"monoclonalCount":249,"pubmedCount":null,"jensenScore":1215.745377,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.40986038077349,"pubTatorScore":3.294348130727778,"self":"https://pharos.nih.gov/idg/api/v1/targets(18904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1229,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/properties"},"_links":{"count":1435,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/links"},"_synonyms":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/synonyms"},"_publications":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/publications"},"_namespace":null},{"id":18905,"version":3,"created":1555017787000,"modified":1555044920000,"deprecated":false,"name":"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2","accession":"O95340","gene":"PAPSS2","description":"Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6398287804241152,"antibodyCount":186,"monoclonalCount":45,"pubmedCount":null,"jensenScore":42.551691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.301352712881204,"pubTatorScore":1.4139912171689335,"self":"https://pharos.nih.gov/idg/api/v1/targets(18905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/publications"},"_namespace":null},{"id":18906,"version":2,"created":1555017794000,"modified":1555017801000,"deprecated":false,"name":"NACHT, LRR and PYD domains-containing protein 1","accession":"Q9C000","gene":"NLRP1","description":"As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0355838445193775,"antibodyCount":183,"monoclonalCount":20,"pubmedCount":null,"jensenScore":116.475351,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.06307774274,"pubTatorScore":2.00871280973622,"self":"https://pharos.nih.gov/idg/api/v1/targets(18906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/properties"},"_links":{"count":1138,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/links"},"_synonyms":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/synonyms"},"_publications":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/publications"},"_namespace":null},{"id":18907,"version":2,"created":1555017802000,"modified":1555017810000,"deprecated":false,"name":"Protein arginine N-methyltransferase 3","accession":"O60678","gene":"PRMT3","description":"Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.3345748389083827,"antibodyCount":254,"monoclonalCount":23,"pubmedCount":null,"jensenScore":21.229985,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.63610078175405,"pubTatorScore":1.4462892720010456,"self":"https://pharos.nih.gov/idg/api/v1/targets(18907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/publications"},"_namespace":null},{"id":18908,"version":2,"created":1555017811000,"modified":1555017818000,"deprecated":false,"name":"Hepatocyte nuclear factor 1-alpha","accession":"P20823","gene":"HNF1A","description":"Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.874391880282467,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":680.87293,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.74951581382574,"pubTatorScore":2.8613712545485304,"self":"https://pharos.nih.gov/idg/api/v1/targets(18908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":703,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/properties"},"_links":{"count":1184,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/synonyms"},"_publications":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/publications"},"_namespace":null},{"id":18909,"version":3,"created":1555017820000,"modified":1555044923000,"deprecated":false,"name":"Cystatin-8","accession":"O60676","gene":"CST8","description":"Performs a specialized role during sperm development and maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.511704577030571,"antibodyCount":163,"monoclonalCount":2,"pubmedCount":null,"jensenScore":292.013911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":16.990382344738403,"pubTatorScore":1.7231916901939994,"self":"https://pharos.nih.gov/idg/api/v1/targets(18909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/properties"},"_links":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/publications"},"_namespace":null},{"id":18910,"version":2,"created":1555017821000,"modified":1555017827000,"deprecated":false,"name":"Bile salt-activated lipase","accession":"P19835","gene":"CEL","description":"Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.572543104520058,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":373.762661,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.22055662032748,"pubTatorScore":2.734166503390985,"self":"https://pharos.nih.gov/idg/api/v1/targets(18910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/publications"},"_namespace":null},{"id":18911,"version":3,"created":1555017828000,"modified":1555044924000,"deprecated":false,"name":"Little elongation complex subunit 2","accession":"Q659A1","gene":"ICE2","description":"Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0336470871676742,"antibodyCount":85,"monoclonalCount":3,"pubmedCount":null,"jensenScore":9.719754,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":32.40346636408697,"pubTatorScore":0.8883666552928718,"self":"https://pharos.nih.gov/idg/api/v1/targets(18911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/publications"},"_namespace":null},{"id":18912,"version":2,"created":1555017834000,"modified":1555017906000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit beta-1","accession":"P18505","gene":"GABRB1","description":"Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.3551975828347904,"antibodyCount":309,"monoclonalCount":84,"pubmedCount":null,"jensenScore":21.739697,"patentCount":1424,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.87513924504769,"pubTatorScore":1.3281132564467366,"self":"https://pharos.nih.gov/idg/api/v1/targets(18912)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/properties"},"_links":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/publications"},"_namespace":null},{"id":18913,"version":4,"created":1555017906000,"modified":1555044926000,"deprecated":false,"name":"Tyrosine-protein kinase JAK2","accession":"O60674","gene":"JAK2","description":"Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.5403663045245417,"antibodyCount":801,"monoclonalCount":85,"pubmedCount":null,"jensenScore":3339.715834,"patentCount":135858,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":68.12410647560435,"pubTatorScore":3.4702308655680247,"self":"https://pharos.nih.gov/idg/api/v1/targets(18913)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1987,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/properties"},"_links":{"count":3691,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/links"},"_synonyms":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/synonyms"},"_publications":{"count":1318,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/publications"},"_namespace":null},{"id":18914,"version":3,"created":1555018173000,"modified":1555044935000,"deprecated":false,"name":"Transcription factor MafK","accession":"O60675","gene":"MAFK","description":"Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5562783894069772,"antibodyCount":111,"monoclonalCount":38,"pubmedCount":null,"jensenScore":33.472597,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.39374390769547,"pubTatorScore":1.2077408412967345,"self":"https://pharos.nih.gov/idg/api/v1/targets(18914)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/publications"},"_namespace":null},{"id":18915,"version":3,"created":1555018179000,"modified":1555044937000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit gamma-2","accession":"P18507","gene":"GABRG2","description":"Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.9336919686848217,"antibodyCount":298,"monoclonalCount":3,"pubmedCount":null,"jensenScore":83.054168,"patentCount":1880,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":38.018629271342704,"pubTatorScore":2.1736932021581783,"self":"https://pharos.nih.gov/idg/api/v1/targets(18915)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/publications"},"_namespace":null},{"id":18916,"version":3,"created":1555018621000,"modified":1555044939000,"deprecated":false,"name":"Ephrin-A1","accession":"P20827","gene":"EFNA1","description":"Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.0262313420045617,"antibodyCount":256,"monoclonalCount":42,"pubmedCount":null,"jensenScore":101.511553,"patentCount":38196,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.610970477704925,"pubTatorScore":2.088094500796962,"self":"https://pharos.nih.gov/idg/api/v1/targets(18916)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/publications"},"_namespace":null},{"id":18917,"version":3,"created":1555018629000,"modified":1555044940000,"deprecated":false,"name":"Nuclear factor NF-kappa-B p105 subunit","accession":"P19838","gene":"NFKB1","description":"NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-2.743491516057702,"antibodyCount":1762,"monoclonalCount":226,"pubmedCount":null,"jensenScore":505.022021,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":64.54162177486675,"pubTatorScore":3.8605698414012086,"self":"https://pharos.nih.gov/idg/api/v1/targets(18917)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":3301,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/properties"},"_links":{"count":3512,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/links"},"_synonyms":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/synonyms"},"_publications":{"count":2592,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/publications"},"_namespace":null},{"id":18918,"version":2,"created":1555018658000,"modified":1555018661000,"deprecated":false,"name":"ATPase family AAA domain-containing protein 3B","accession":"Q5T9A4","gene":"ATAD3B","description":"May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8346326164696298,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.271367,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.50232735942464,"pubTatorScore":0.8522765229330588,"self":"https://pharos.nih.gov/idg/api/v1/targets(18918)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/publications"},"_namespace":null},{"id":18919,"version":2,"created":1555018662000,"modified":1555018668000,"deprecated":false,"name":"DNA polymerase zeta catalytic subunit","accession":"O60673","gene":"REV3L","description":"Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2010822316906276,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":158.499291,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.352661968772,"pubTatorScore":1.8073526808166966,"self":"https://pharos.nih.gov/idg/api/v1/targets(18919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/publications"},"_namespace":null},{"id":18920,"version":3,"created":1555018669000,"modified":1555044952000,"deprecated":false,"name":"Pituitary adenylate cyclase-activating polypeptide","accession":"P18509","gene":"ADCYAP1","description":"Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0511519795796183,"antibodyCount":174,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1255.156686,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":34.03889175707268,"pubTatorScore":2.7409151466686907,"self":"https://pharos.nih.gov/idg/api/v1/targets(18920)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/publications"},"_namespace":null},{"id":18921,"version":3,"created":1555018676000,"modified":1555044953000,"deprecated":false,"name":"Cell cycle checkpoint protein RAD1","accession":"O60671","gene":"RAD1","description":"Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.9171259852291596,"antibodyCount":245,"monoclonalCount":71,"pubmedCount":null,"jensenScore":78.345802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.24103558649805,"pubTatorScore":2.02409183284047,"self":"https://pharos.nih.gov/idg/api/v1/targets(18921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/publications"},"_namespace":null},{"id":18922,"version":3,"created":1555018683000,"modified":1555044955000,"deprecated":false,"name":"Ephexin-1","accession":"Q8N5V2","gene":"NGEF","description":"Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1828778104174322,"antibodyCount":77,"monoclonalCount":5,"pubmedCount":null,"jensenScore":15.660931,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":33.03328046269165,"pubTatorScore":0.8684857949700635,"self":"https://pharos.nih.gov/idg/api/v1/targets(18922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/publications"},"_namespace":null},{"id":18923,"version":2,"created":1555018689000,"modified":1555018689000,"deprecated":false,"name":"Putative speedy protein-like protein 3","accession":"A6NJR5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/publications"},"_namespace":null},{"id":18924,"version":2,"created":1555018689000,"modified":1555018694000,"deprecated":false,"name":"Inactive ubiquitin carboxyl-terminal hydrolase 53","accession":"Q70EK8","gene":"USP53","description":"Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.02374410310654272,"antibodyCount":61,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.535714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.17500091800729,"pubTatorScore":-0.1760916933503803,"self":"https://pharos.nih.gov/idg/api/v1/targets(18924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/publications"},"_namespace":null},{"id":18925,"version":2,"created":1555018695000,"modified":1555018698000,"deprecated":false,"name":"L-lactate dehydrogenase C chain","accession":"P07864","gene":"LDHC","description":"Possible role in sperm motility.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.715260293781856,"antibodyCount":181,"monoclonalCount":15,"pubmedCount":null,"jensenScore":512.101056,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.832366113551434,"pubTatorScore":2.3715515576481057,"self":"https://pharos.nih.gov/idg/api/v1/targets(18925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/publications"},"_namespace":null},{"id":18926,"version":2,"created":1555018699000,"modified":1555018703000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 51","accession":"Q70EK9","gene":"USP51","description":"Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.06159606876482926,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.346464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.224634831941618,"pubTatorScore":-0.25218128028125936,"self":"https://pharos.nih.gov/idg/api/v1/targets(18926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/publications"},"_namespace":null},{"id":18927,"version":2,"created":1555018703000,"modified":1555018709000,"deprecated":false,"name":"Seizure 6-like protein 2","accession":"Q6UXD5","gene":"SEZ6L2","description":"May contribute to specialized endoplasmic reticulum functions in neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2567953676783747,"antibodyCount":56,"monoclonalCount":6,"pubmedCount":null,"jensenScore":14.003352,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.35477654137791,"pubTatorScore":0.8585239640181548,"self":"https://pharos.nih.gov/idg/api/v1/targets(18927)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/publications"},"_namespace":null},{"id":18928,"version":2,"created":1555018710000,"modified":1555018717000,"deprecated":false,"name":"T-cell differentiation antigen CD6","accession":"P30203","gene":"CD6","description":"Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.073518642523458,"antibodyCount":707,"monoclonalCount":567,"pubmedCount":null,"jensenScore":1124.266478,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.752802635134266,"pubTatorScore":2.7169342618173493,"self":"https://pharos.nih.gov/idg/api/v1/targets(18928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/publications"},"_namespace":null},{"id":18929,"version":2,"created":1555018718000,"modified":1555018720000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 7","accession":"Q6UXD7","gene":"SLC49A3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5362427068383191,"antibodyCount":18,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.121795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4648869792587226,"self":"https://pharos.nih.gov/idg/api/v1/targets(18929)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/publications"},"_namespace":null},{"id":18930,"version":2,"created":1555018721000,"modified":1555018723000,"deprecated":false,"name":"Zinc finger protein 543","accession":"Q08ER8","gene":"ZNF543","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.12493873552256378,"antibodyCount":87,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.745327817923087,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/publications"},"_namespace":null},{"id":18931,"version":2,"created":1555018724000,"modified":1555018730000,"deprecated":false,"name":"Transforming acidic coiled-coil-containing protein 2","accession":"O95359","gene":"TACC2","description":"Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. 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Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2300867839480003,"antibodyCount":518,"monoclonalCount":221,"pubmedCount":null,"jensenScore":172.684169,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":46.57854216544793,"pubTatorScore":2.234010369103148,"self":"https://pharos.nih.gov/idg/api/v1/targets(53)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":499,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/publications"},"_namespace":null},{"id":54,"version":2,"created":1554856048000,"modified":1554856055000,"deprecated":false,"name":"Apoptotic chromatin condensation inducer in the nucleus","accession":"Q9UKV3","gene":"ACIN1","description":"Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5198673886776983,"antibodyCount":429,"monoclonalCount":14,"pubmedCount":null,"jensenScore":31.12438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.411551305928015,"pubTatorScore":1.4362667538798783,"self":"https://pharos.nih.gov/idg/api/v1/targets(54)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/properties"},"_links":{"count":1265,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/publications"},"_namespace":null},{"id":55,"version":3,"created":1554856056000,"modified":1555032402000,"deprecated":false,"name":"AN1-type zinc finger protein 4","accession":"Q86XD8","gene":"ZFAND4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.409369470018525,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.616666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.31928535073546,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(55)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/properties"},"_links":{"count":840,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/publications"},"_namespace":null},{"id":56,"version":3,"created":1554856060000,"modified":1554856112000,"deprecated":false,"name":"Histone deacetylase 9","accession":"Q9UKV0","gene":"HDAC9","description":"Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-2.273089497091032,"antibodyCount":431,"monoclonalCount":68,"pubmedCount":null,"jensenScore":185.173288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":56.23984089559329,"pubTatorScore":2.7473718144377592,"self":"https://pharos.nih.gov/idg/api/v1/targets(56)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/properties"},"_links":{"count":1180,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/links"},"_synonyms":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/publications"},"_namespace":null},{"id":57,"version":3,"created":1554856114000,"modified":1555032405000,"deprecated":false,"name":"Protein FAM131B","accession":"Q86XD5","gene":"FAM131B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.10720996964786837,"antibodyCount":27,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.975406,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":28.419123661868465,"pubTatorScore":-0.3316989001708281,"self":"https://pharos.nih.gov/idg/api/v1/targets(57)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/publications"},"_namespace":null},{"id":58,"version":2,"created":1554856118000,"modified":1554856124000,"deprecated":false,"name":"E3 ubiquitin-protein ligase AMFR","accession":"Q9UKV5","gene":"AMFR","description":"E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.46909370714568,"antibodyCount":203,"monoclonalCount":10,"pubmedCount":null,"jensenScore":292.79011,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.332123968726236,"pubTatorScore":2.0521588108357567,"self":"https://pharos.nih.gov/idg/api/v1/targets(58)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":491,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/properties"},"_links":{"count":1096,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/publications"},"_namespace":null},{"id":59,"version":3,"created":1554856125000,"modified":1555032406000,"deprecated":false,"name":"Myotubularin-related protein 10","accession":"Q9NXD2","gene":"MTMR10","description":"Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.09863683241885936,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.581547,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.564237544316658,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(59)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/publications"},"_namespace":null},{"id":60,"version":2,"created":1554856129000,"modified":1554856133000,"deprecated":false,"name":"WD repeat-containing protein 91","accession":"A4D1P6","gene":"WDR91","description":"Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7290297371187089,"antibodyCount":54,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.455556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.449377626796103,"pubTatorScore":-0.12979104421422474,"self":"https://pharos.nih.gov/idg/api/v1/targets(60)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/publications"},"_namespace":null},{"id":61,"version":3,"created":1554856134000,"modified":1555032409000,"deprecated":false,"name":"Protein argonaute-2","accession":"Q9UKV8","gene":"AGO2","description":"Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.972430242380369,"antibodyCount":202,"monoclonalCount":44,"pubmedCount":null,"jensenScore":867.10533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":49.5380576746982,"pubTatorScore":3.182079452361696,"self":"https://pharos.nih.gov/idg/api/v1/targets(61)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/properties"},"_links":{"count":1348,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/synonyms"},"_publications":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/publications"},"_namespace":null},{"id":62,"version":3,"created":1554856148000,"modified":1555032411000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 10","accession":"Q5BKY1","gene":"LRRC10","description":"May play important roles in cardiac development and/or cardiac function.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9311187105921871,"antibodyCount":42,"monoclonalCount":3,"pubmedCount":null,"jensenScore":8.186527,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":18.954198517230957,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(62)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/properties"},"_links":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/publications"},"_namespace":null},{"id":63,"version":2,"created":1554856150000,"modified":1554856150000,"deprecated":false,"name":"Putative uncharacterized protein DKFZp434K191","accession":"Q5BKY6","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(63)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/publications"},"_namespace":null},{"id":64,"version":3,"created":1554856150000,"modified":1555032413000,"deprecated":false,"name":"5-hydroxytryptamine receptor 3C","accession":"Q8WXA8","gene":"HTR3C","description":"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. 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Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). 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Required for the incorporation of MINOS1/MIC10 into the MICOS complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2234298503668208,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.473778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3730433755813021,"self":"https://pharos.nih.gov/idg/api/v1/targets(313)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/publications"},"_namespace":null},{"id":314,"version":3,"created":1554857757000,"modified":1555032564000,"deprecated":false,"name":"Sorting nexin-8","accession":"Q9Y5X2","gene":"SNX8","description":"May be involved in several stages of intracellular trafficking. 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The immediate electron acceptor for the enzyme is believed to be ubiquinone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.6279426493278188,"antibodyCount":65,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.794264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.72908359979191,"pubTatorScore":0.5913737369240128,"self":"https://pharos.nih.gov/idg/api/v1/targets(569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/publications"},"_namespace":null},{"id":570,"version":3,"created":1554859228000,"modified":1555032682000,"deprecated":false,"name":"Protein ecdysoneless homolog","accession":"O95905","gene":"ECD","description":"Regulator of p53/TP53 stability and function. 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May play a role in regulation of pre-mRNA splicing (PubMed:24722212).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7224511098365303,"antibodyCount":113,"monoclonalCount":29,"pubmedCount":null,"jensenScore":9.930693,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":31.82522464187388,"pubTatorScore":1.4785727141845941,"self":"https://pharos.nih.gov/idg/api/v1/targets(570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/publications"},"_namespace":null},{"id":571,"version":2,"created":1554859231000,"modified":1554859234000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 13C","accession":"Q96RJ3","gene":"TNFRSF13C","description":"B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. 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Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6389435732694202,"antibodyCount":185,"monoclonalCount":20,"pubmedCount":null,"jensenScore":37.172194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":41.27191991083502,"pubTatorScore":1.9194172694651233,"self":"https://pharos.nih.gov/idg/api/v1/targets(572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/properties"},"_links":{"count":1208,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/publications"},"_namespace":null},{"id":573,"version":3,"created":1554859239000,"modified":1555032685000,"deprecated":false,"name":"Monocarboxylate transporter 3","accession":"O95907","gene":"SLC16A8","description":"Proton-linked monocarboxylate transporter. 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Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.4944417054391943,"antibodyCount":117,"monoclonalCount":2,"pubmedCount":null,"jensenScore":308.838744,"patentCount":42640,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.084431388303091,"pubTatorScore":2.0947234213187165,"self":"https://pharos.nih.gov/idg/api/v1/targets(575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/properties"},"_links":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/publications"},"_namespace":null},{"id":576,"version":2,"created":1554859267000,"modified":1554859270000,"deprecated":false,"name":"3-hydroxybutyrate dehydrogenase type 2","accession":"Q9BUT1","gene":"BDH2","description":"Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. 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Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.051975040292868,"antibodyCount":194,"monoclonalCount":46,"pubmedCount":null,"jensenScore":103.280877,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.93205805395832,"pubTatorScore":2.0064524484052617,"self":"https://pharos.nih.gov/idg/api/v1/targets(578)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/publications"},"_namespace":null},{"id":579,"version":2,"created":1554859277000,"modified":1554859280000,"deprecated":false,"name":"2'-5'-oligoadenylate synthase 3","accession":"Q9Y6K5","gene":"OAS3","description":"Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3008338257285097,"antibodyCount":141,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.827496,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.84520077742047,"pubTatorScore":2.0575477292221613,"self":"https://pharos.nih.gov/idg/api/v1/targets(579)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/publications"},"_namespace":null},{"id":580,"version":2,"created":1554859280000,"modified":1554859285000,"deprecated":false,"name":"Neurexin-1","accession":"Q9ULB1","gene":"NRXN1","description":"Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. 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Required for normal trabecular bone mass and cortical bone composition (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-1.7248905183458925,"antibodyCount":555,"monoclonalCount":274,"pubmedCount":null,"jensenScore":55.353477,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":55.64424860530742,"pubTatorScore":2.642694524601589,"self":"https://pharos.nih.gov/idg/api/v1/targets(875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":635,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/properties"},"_links":{"count":1279,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/synonyms"},"_publications":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/publications"},"_namespace":null},{"id":876,"version":3,"created":1554860247000,"modified":1555032860000,"deprecated":false,"name":"NAD-dependent protein lipoamidase sirtuin-4, mitochondrial","accession":"Q9Y6E7","gene":"SIRT4","description":"Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. 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Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). 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May act as a key regulator of axon regeneration in the optic nerve and radial nerve.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.2411032400775732,"antibodyCount":243,"monoclonalCount":21,"pubmedCount":null,"jensenScore":132.946855,"patentCount":36691,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.04200650610785,"pubTatorScore":1.832932379611627,"self":"https://pharos.nih.gov/idg/api/v1/targets(877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/publications"},"_namespace":null},{"id":878,"version":2,"created":1554860256000,"modified":1554860259000,"deprecated":false,"name":"Serine/threonine-protein kinase VRK2","accession":"Q86Y07","gene":"VRK2","description":"Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. 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May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, 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Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). 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Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.9452644104964283,"antibodyCount":215,"monoclonalCount":10,"pubmedCount":null,"jensenScore":841.849063,"patentCount":52493,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.069459559801906,"pubTatorScore":2.4431387771264363,"self":"https://pharos.nih.gov/idg/api/v1/targets(957)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/publications"},"_namespace":null},{"id":958,"version":2,"created":1554860837000,"modified":1554860840000,"deprecated":false,"name":"Arginine and glutamate-rich protein 1","accession":"Q9NWB6","gene":"ARGLU1","description":"Required for the estrogen-dependent expression of ESR1 target genes. 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Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3103078165210995,"antibodyCount":197,"monoclonalCount":81,"pubmedCount":null,"jensenScore":23.778247,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":37,"knowledgeAvailability":37.06892612559948,"pubTatorScore":1.0583550661791215,"self":"https://pharos.nih.gov/idg/api/v1/targets(961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/publications"},"_namespace":null},{"id":962,"version":2,"created":1554860858000,"modified":1554860860000,"deprecated":false,"name":"E3 ubiquitin ligase RNF157","accession":"Q96PX1","gene":"RNF157","description":"E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). 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Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. 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Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). 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Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.50531677942882,"antibodyCount":1102,"monoclonalCount":740,"pubmedCount":null,"jensenScore":3420.908916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":44.5215726745551,"pubTatorScore":3.2237410148120276,"self":"https://pharos.nih.gov/idg/api/v1/targets(19064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1680,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/properties"},"_links":{"count":2167,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/synonyms"},"_publications":{"count":1261,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/publications"},"_namespace":null},{"id":19065,"version":3,"created":1555019546000,"modified":1555045034000,"deprecated":false,"name":"Adenylyltransferase and sulfurtransferase MOCS3","accession":"O95396","gene":"MOCS3","description":"Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0867833952357453,"antibodyCount":128,"monoclonalCount":35,"pubmedCount":null,"jensenScore":10.918263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":34.78960387876799,"pubTatorScore":0.9976151370397195,"self":"https://pharos.nih.gov/idg/api/v1/targets(19065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/publications"},"_namespace":null},{"id":19066,"version":2,"created":1555019550000,"modified":1555019553000,"deprecated":false,"name":"CCAAT/enhancer-binding protein zeta","accession":"Q03701","gene":"CEBPZ","description":"Stimulates transcription from the HSP70 promoter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8404294984415146,"antibodyCount":126,"monoclonalCount":3,"pubmedCount":null,"jensenScore":65.823589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.505262155592526,"pubTatorScore":2.3204825803275275,"self":"https://pharos.nih.gov/idg/api/v1/targets(19066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/publications"},"_namespace":null},{"id":19067,"version":3,"created":1555019554000,"modified":1555045035000,"deprecated":false,"name":"Toll-like receptor 5","accession":"O60602","gene":"TLR5","description":"Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7928020310007335,"antibodyCount":691,"monoclonalCount":275,"pubmedCount":null,"jensenScore":635.609353,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":41.42984169693781,"pubTatorScore":2.4552673250911106,"self":"https://pharos.nih.gov/idg/api/v1/targets(19067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/synonyms"},"_publications":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/publications"},"_namespace":null},{"id":19068,"version":2,"created":1555019560000,"modified":1555019563000,"deprecated":false,"name":"Membrane protein FAM159A","accession":"Q6UWV7","gene":"SHISAL2A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/properties"},"_links":{"count":653,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/publications"},"_namespace":null},{"id":19069,"version":2,"created":1555019563000,"modified":1555019565000,"deprecated":false,"name":"Protein PIH1D3","accession":"Q9NQM4","gene":"PIH1D3","description":"Plays a role in cytoplasmic pre-assembly of axonemal dynein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2846992279675036,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.989286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.29426768657019,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/properties"},"_links":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/publications"},"_namespace":null},{"id":19070,"version":2,"created":1555019565000,"modified":1555019571000,"deprecated":false,"name":"Multiple epidermal growth factor-like domains protein 10","accession":"Q96KG7","gene":"MEGF10","description":"Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3419586332852893,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.898199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.37396671451192,"pubTatorScore":1.210868839285683,"self":"https://pharos.nih.gov/idg/api/v1/targets(19070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/publications"},"_namespace":null},{"id":19071,"version":3,"created":1555019571000,"modified":1555019580000,"deprecated":false,"name":"Acetyl-CoA carboxylase 1","accession":"Q13085","gene":"ACACA","description":"Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.143452355143252,"antibodyCount":426,"monoclonalCount":82,"pubmedCount":null,"jensenScore":1376.636972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":58.82133033110529,"pubTatorScore":2.0843942686252053,"self":"https://pharos.nih.gov/idg/api/v1/targets(19071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":491,"href":"https://pharos.nih.gov/idg/api/v1/targets(19071)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(19071)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(19071)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(19071)/publications"},"_namespace":null},{"id":19072,"version":2,"created":1555019582000,"modified":1555019585000,"deprecated":false,"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9","accession":"Q6UX72","gene":"B3GNT9","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.052632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.517433465874177,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(19072)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(19072)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(19072)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(19072)/publications"},"_namespace":null},{"id":19073,"version":2,"created":1555019585000,"modified":1555019589000,"deprecated":false,"name":"Myelin protein zero-like protein 3","accession":"Q6UWV2","gene":"MPZL3","description":"Mediates homophilic cell-cell adhesion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5808706922580243,"antibodyCount":70,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.051165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.18417142538975,"pubTatorScore":0.3521825181113625,"self":"https://pharos.nih.gov/idg/api/v1/targets(19073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(19073)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(19073)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(19073)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(19073)/publications"},"_namespace":null},{"id":19074,"version":3,"created":1555019589000,"modified":1555045037000,"deprecated":false,"name":"N-terminal kinase-like protein","accession":"Q96KG9","gene":"SCYL1","description":"Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. 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The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5409786306317814,"antibodyCount":92,"monoclonalCount":12,"pubmedCount":null,"jensenScore":317.438117,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":47.17152609224794,"pubTatorScore":2.3591172731171177,"self":"https://pharos.nih.gov/idg/api/v1/targets(19187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":571,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/properties"},"_links":{"count":1296,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/synonyms"},"_publications":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/publications"},"_namespace":null},{"id":19188,"version":3,"created":1555020180000,"modified":1555045094000,"deprecated":false,"name":"Protein delta homolog 2","accession":"Q6UY11","gene":"DLK2","description":"Regulates adipogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7730033541052158,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.460833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":27.461806966863307,"pubTatorScore":0.03302305466873799,"self":"https://pharos.nih.gov/idg/api/v1/targets(19188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/properties"},"_links":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/publications"},"_namespace":null},{"id":19189,"version":3,"created":1555020183000,"modified":1555045095000,"deprecated":false,"name":"(E3-independent) E2 ubiquitin-conjugating enzyme","accession":"Q9C0C9","gene":"UBE2O","description":"E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0791538516157178,"antibodyCount":104,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.607705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.599395356841185,"pubTatorScore":0.5826314394896365,"self":"https://pharos.nih.gov/idg/api/v1/targets(19189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/publications"},"_namespace":null},{"id":19190,"version":2,"created":1555020189000,"modified":1555020190000,"deprecated":false,"name":"Transmembrane protein 14EP","accession":"Q6UXP3","gene":"TMEM14EP","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/properties"},"_links":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/links"},"_synonyms":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/publications"},"_namespace":null},{"id":19191,"version":3,"created":1555020190000,"modified":1555045096000,"deprecated":false,"name":"CLOCK-interacting pacemaker","accession":"Q9C0C6","gene":"CIPC","description":"Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. 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The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. 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Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.2667545718175552,"antibodyCount":1396,"monoclonalCount":234,"pubmedCount":null,"jensenScore":1515.740982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":60.00651512753951,"pubTatorScore":2.7141398393111382,"self":"https://pharos.nih.gov/idg/api/v1/targets(19236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/properties"},"_links":{"count":1511,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/synonyms"},"_publications":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/publications"},"_namespace":null},{"id":19237,"version":3,"created":1555020510000,"modified":1555045128000,"deprecated":false,"name":"5'-AMP-activated protein kinase catalytic subunit alpha-1","accession":"Q13131","gene":"PRKAA1","description":"Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.9282357834409767,"antibodyCount":953,"monoclonalCount":183,"pubmedCount":null,"jensenScore":74.344626,"patentCount":2819,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":56.443209744834704,"pubTatorScore":2.579215918311512,"self":"https://pharos.nih.gov/idg/api/v1/targets(19237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/properties"},"_links":{"count":1371,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/synonyms"},"_publications":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/publications"},"_namespace":null},{"id":19238,"version":2,"created":1555020525000,"modified":1555020532000,"deprecated":false,"name":"Alpha-ketoglutarate-dependent dioxygenase FTO","accession":"Q9C0B1","gene":"FTO","description":"Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). In particular, it is involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.1302110976303124,"antibodyCount":318,"monoclonalCount":63,"pubmedCount":null,"jensenScore":1342.048711,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.06266046942067,"pubTatorScore":3.032182221411047,"self":"https://pharos.nih.gov/idg/api/v1/targets(19238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/properties"},"_links":{"count":1673,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/synonyms"},"_publications":{"count":649,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/publications"},"_namespace":null},{"id":19239,"version":2,"created":1555020535000,"modified":1555020538000,"deprecated":false,"name":"Cilia- and flagella-associated protein 74","accession":"Q9C0B2","gene":"CFAP74","description":"As part of the central apparatus of the cilium axoneme may play a role in cilium movement.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.38021124171160603,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.160256,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.777030828700669,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/properties"},"_links":{"count":717,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/publications"},"_namespace":null},{"id":19240,"version":2,"created":1555020539000,"modified":1555020545000,"deprecated":false,"name":"Transcription factor HES-1","accession":"Q14469","gene":"HES1","description":"Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7740885523365773,"antibodyCount":444,"monoclonalCount":158,"pubmedCount":null,"jensenScore":55.536295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.353035556015655,"pubTatorScore":2.518945596934086,"self":"https://pharos.nih.gov/idg/api/v1/targets(19240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":496,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/synonyms"},"_publications":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/publications"},"_namespace":null},{"id":19241,"version":3,"created":1555020547000,"modified":1555045131000,"deprecated":false,"name":"Calcium-binding and coiled-coil domain-containing protein 2","accession":"Q13137","gene":"CALCOCO2","description":"Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.413701946247204,"antibodyCount":255,"monoclonalCount":185,"pubmedCount":null,"jensenScore":234.003383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":37.21787078864689,"pubTatorScore":1.4004889450192652,"self":"https://pharos.nih.gov/idg/api/v1/targets(19241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/properties"},"_links":{"count":1143,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/publications"},"_namespace":null},{"id":19242,"version":3,"created":1555020553000,"modified":1555045133000,"deprecated":false,"name":"Mothers against decapentaplegic homolog 1","accession":"Q15797","gene":"SMAD1","description":"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.9357609353861517,"antibodyCount":897,"monoclonalCount":136,"pubmedCount":null,"jensenScore":6.899748,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":50.867274936435685,"pubTatorScore":2.196006962445458,"self":"https://pharos.nih.gov/idg/api/v1/targets(19242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":634,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/properties"},"_links":{"count":1156,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/synonyms"},"_publications":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/publications"},"_namespace":null},{"id":19243,"version":3,"created":1555020560000,"modified":1555045135000,"deprecated":false,"name":"Liprin-alpha-1","accession":"Q13136","gene":"PPFIA1","description":"May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6322213602259907,"antibodyCount":131,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.971909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":45.760577295871826,"pubTatorScore":1.6568456953210529,"self":"https://pharos.nih.gov/idg/api/v1/targets(19243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/publications"},"_namespace":null},{"id":19244,"version":3,"created":1555020568000,"modified":1555045136000,"deprecated":false,"name":"Polynucleotide 5'-hydroxyl-kinase NOL9","accession":"Q5SY16","gene":"NOL9","description":"Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.0914156945232518,"antibodyCount":29,"monoclonalCount":1,"pubmedCount":null,"jensenScore":11.051948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":36.4502118279985,"pubTatorScore":0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(19244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/publications"},"_namespace":null},{"id":19245,"version":2,"created":1555020573000,"modified":1555020575000,"deprecated":false,"name":"EP300-interacting inhibitor of differentiation 2","accession":"Q8N6I1","gene":"EID2","description":"Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. 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May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3664229843693787,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.133264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.11820278277214,"pubTatorScore":1.3024752437523561,"self":"https://pharos.nih.gov/idg/api/v1/targets(19245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/publications"},"_namespace":null},{"id":19246,"version":2,"created":1555020576000,"modified":1555020577000,"deprecated":false,"name":"Putative uncharacterized protein encoded by COL5A1-AS1","accession":"Q5SY13","gene":"COL5A1-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.8491363490076624,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19246)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/publications"},"_namespace":null},{"id":19247,"version":3,"created":1555020577000,"modified":1555045137000,"deprecated":false,"name":"Protein HIRA","accession":"P54198","gene":"HIRA","description":"Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6251816594230253,"antibodyCount":188,"monoclonalCount":30,"pubmedCount":null,"jensenScore":39.917511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.864778202272205,"pubTatorScore":1.9339647694477422,"self":"https://pharos.nih.gov/idg/api/v1/targets(19247)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/properties"},"_links":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/publications"},"_namespace":null},{"id":19248,"version":3,"created":1555020584000,"modified":1555045139000,"deprecated":false,"name":"TOMM20-like protein 1","accession":"Q6UXN7","gene":"TOMM20L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":57,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":19.01871869294766,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/properties"},"_links":{"count":699,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/publications"},"_namespace":null},{"id":19249,"version":2,"created":1555020586000,"modified":1555020588000,"deprecated":false,"name":"CMRF35-like molecule 7","accession":"A8K4G0","gene":"CD300LB","description":"Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8524218899644638,"antibodyCount":74,"monoclonalCount":4,"pubmedCount":null,"jensenScore":10.394955,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.379594054933474,"pubTatorScore":0.6582763786101274,"self":"https://pharos.nih.gov/idg/api/v1/targets(19249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/properties"},"_links":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/publications"},"_namespace":null},{"id":19250,"version":2,"created":1555020588000,"modified":1555020591000,"deprecated":false,"name":"WD repeat-containing protein 82","accession":"Q6UXN9","gene":"WDR82","description":"Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. 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Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1388588424682835,"antibodyCount":339,"monoclonalCount":40,"pubmedCount":null,"jensenScore":158.918806,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":29,"knowledgeAvailability":39.557551086009276,"pubTatorScore":3.3061619700431093,"self":"https://pharos.nih.gov/idg/api/v1/targets(19336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/publications"},"_namespace":null},{"id":19337,"version":2,"created":1555021148000,"modified":1555021151000,"deprecated":false,"name":"Germ cell-specific gene 1-like protein","accession":"Q6UXU4","gene":"GSG1L","description":"As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6977996607389556,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.033,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.753793318868023,"pubTatorScore":0.10833936198506207,"self":"https://pharos.nih.gov/idg/api/v1/targets(19337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/properties"},"_links":{"count":776,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/publications"},"_namespace":null},{"id":19338,"version":3,"created":1555021151000,"modified":1555045185000,"deprecated":false,"name":"Zeta-sarcoglycan","accession":"Q96LD1","gene":"SGCZ","description":"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. 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During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. 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The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.","idgFamily":"Nuclear Receptor","idgTDL":"Tclin","novelty":-2.4828542666198055,"antibodyCount":299,"monoclonalCount":99,"pubmedCount":null,"jensenScore":237.893733,"patentCount":8536,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":58.14639597024445,"pubTatorScore":3.145644798584117,"self":"https://pharos.nih.gov/idg/api/v1/targets(19437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":832,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/properties"},"_links":{"count":1464,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/links"},"_synonyms":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/synonyms"},"_publications":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/publications"},"_namespace":null},{"id":19438,"version":3,"created":1555021713000,"modified":1555045234000,"deprecated":false,"name":"Transmembrane protein 108","accession":"Q6UXF1","gene":"TMEM108","description":"Transmembrane protein required for proper cognitive functions. 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Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.02996322279838387,"antibodyCount":155,"monoclonalCount":30,"pubmedCount":null,"jensenScore":1.295238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.902492644625568,"pubTatorScore":0.06694654146226692,"self":"https://pharos.nih.gov/idg/api/v1/targets(19711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/publications"},"_namespace":null},{"id":19712,"version":3,"created":1555025100000,"modified":1555045420000,"deprecated":false,"name":"CD70 antigen","accession":"P32970","gene":"CD70","description":"Cytokine that binds to CD27. 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Also involved in G2/M progression and cytokinesis.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.0408087780685533,"antibodyCount":419,"monoclonalCount":84,"pubmedCount":null,"jensenScore":103.630478,"patentCount":12192,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":54.50083982612412,"pubTatorScore":1.9399232031678026,"self":"https://pharos.nih.gov/idg/api/v1/targets(19868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/publications"},"_namespace":null},{"id":19869,"version":4,"created":1555026672000,"modified":1555045531000,"deprecated":false,"name":"Proto-oncogene tyrosine-protein kinase receptor Ret","accession":"P07949","gene":"RET","description":"Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.4280118192439217,"antibodyCount":880,"monoclonalCount":256,"pubmedCount":null,"jensenScore":2821.419851,"patentCount":180270,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":58.632163368423384,"pubTatorScore":3.5294865656836096,"self":"https://pharos.nih.gov/idg/api/v1/targets(19869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/properties"},"_links":{"count":1863,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/synonyms"},"_publications":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/publications"},"_namespace":null},{"id":19870,"version":3,"created":1555026716000,"modified":1555045536000,"deprecated":false,"name":"Tyrosine-protein kinase Lyn","accession":"P07948","gene":"LYN","description":"Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.836439114738024,"antibodyCount":589,"monoclonalCount":121,"pubmedCount":null,"jensenScore":683.181822,"patentCount":59678,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":62.50683905622742,"pubTatorScore":2.6408893569299225,"self":"https://pharos.nih.gov/idg/api/v1/targets(19870)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/properties"},"_links":{"count":1186,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/synonyms"},"_publications":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/publications"},"_namespace":null},{"id":19871,"version":2,"created":1555026734000,"modified":1555026738000,"deprecated":false,"name":"Zinc finger MYM-type protein 1","accession":"Q5SVZ6","gene":"ZMYM1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.32307958618782,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19871)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/properties"},"_links":{"count":799,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/publications"},"_namespace":null},{"id":19872,"version":3,"created":1555026738000,"modified":1555045538000,"deprecated":false,"name":"Myelin-associated glycoprotein","accession":"P20916","gene":"MAG","description":"Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.9504408799361865,"antibodyCount":257,"monoclonalCount":45,"pubmedCount":null,"jensenScore":775.043081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":31.430765632284096,"pubTatorScore":2.7542916734061973,"self":"https://pharos.nih.gov/idg/api/v1/targets(19872)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/publications"},"_namespace":null},{"id":19873,"version":2,"created":1555026749000,"modified":1555026749000,"deprecated":false,"name":"Protein FAM27E3","accession":"Q08E93","gene":"FAM27E3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.307969591754636,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/publications"},"_namespace":null},{"id":19874,"version":2,"created":1555026749000,"modified":1555026754000,"deprecated":false,"name":"Frizzled-3","accession":"Q9NPG1","gene":"FZD3","description":"Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.7652828250597803,"antibodyCount":314,"monoclonalCount":53,"pubmedCount":null,"jensenScore":56.437018,"patentCount":5487,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.84678063011598,"pubTatorScore":1.6256619482274184,"self":"https://pharos.nih.gov/idg/api/v1/targets(19874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/publications"},"_namespace":null},{"id":19875,"version":3,"created":1555026755000,"modified":1555045540000,"deprecated":false,"name":"Neuroglobin","accession":"Q9NPG2","gene":"NGB","description":"Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5455438932066303,"antibodyCount":196,"monoclonalCount":21,"pubmedCount":null,"jensenScore":397.848093,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":22.80411916899304,"pubTatorScore":2.401752073598697,"self":"https://pharos.nih.gov/idg/api/v1/targets(19875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/properties"},"_links":{"count":615,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/publications"},"_namespace":null},{"id":19876,"version":2,"created":1555026761000,"modified":1555026766000,"deprecated":false,"name":"Ubinuclein-1","accession":"Q9NPG3","gene":"UBN1","description":"Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5243137060432528,"antibodyCount":87,"monoclonalCount":20,"pubmedCount":null,"jensenScore":27.527865,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.72713065857093,"pubTatorScore":1.170831909968437,"self":"https://pharos.nih.gov/idg/api/v1/targets(19876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/publications"},"_namespace":null},{"id":19877,"version":3,"created":1555026767000,"modified":1555045541000,"deprecated":false,"name":"Protocadherin-12","accession":"Q9NPG4","gene":"PCDH12","description":"Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9364127074563352,"antibodyCount":72,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.190273,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":30.092195572854298,"pubTatorScore":0.6004470702839172,"self":"https://pharos.nih.gov/idg/api/v1/targets(19877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/publications"},"_namespace":null},{"id":19878,"version":3,"created":1555026771000,"modified":1555045543000,"deprecated":false,"name":"Coiled-coil domain-containing protein 82","accession":"Q8N4S0","gene":"CCDC82","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.052632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":28.62303942524901,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(19878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/publications"},"_namespace":null},{"id":19879,"version":2,"created":1555026776000,"modified":1555026779000,"deprecated":false,"name":"Probable palmitoyltransferase ZDHHC4","accession":"Q9NPG8","gene":"ZDHHC4","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.7496763827231845,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":55.109533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.48484137060833,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(19879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/publications"},"_namespace":null},{"id":19880,"version":2,"created":1555026780000,"modified":1555026784000,"deprecated":false,"name":"Prolyl 3-hydroxylase OGFOD1","accession":"Q8N543","gene":"OGFOD1","description":"Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. 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Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.44380970646793,"antibodyCount":357,"monoclonalCount":113,"pubmedCount":null,"jensenScore":269.903635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":40.14691569834221,"pubTatorScore":2.104056690485035,"self":"https://pharos.nih.gov/idg/api/v1/targets(19898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/publications"},"_namespace":null},{"id":19899,"version":2,"created":1555026910000,"modified":1555026912000,"deprecated":false,"name":"Protein ARMCX6","accession":"Q7L4S7","gene":"ARMCX6","description":"May regulate the dynamics and distribution of mitochondria in neural cells.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.337729904320117,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/publications"},"_namespace":null},{"id":19900,"version":2,"created":1555026913000,"modified":1555026917000,"deprecated":false,"name":"Transmembrane protein 138","accession":"Q9NPI0","gene":"TMEM138","description":"Required for ciliogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.24966862972337267,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.746212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.70430207565234,"pubTatorScore":0.03218465235036576,"self":"https://pharos.nih.gov/idg/api/v1/targets(19900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/publications"},"_namespace":null},{"id":19901,"version":2,"created":1555026917000,"modified":1555026921000,"deprecated":false,"name":"Ubiquinol-cytochrome-c reductase complex assembly factor 3","accession":"Q6UW78","gene":"UQCC3","description":"Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. 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Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. 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Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. 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Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9697310830132702,"antibodyCount":54,"monoclonalCount":3,"pubmedCount":null,"jensenScore":94.963955,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.455312637699558,"pubTatorScore":0.7877807990888366,"self":"https://pharos.nih.gov/idg/api/v1/targets(19906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/properties"},"_links":{"count":1254,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/publications"},"_namespace":null},{"id":19907,"version":2,"created":1555026943000,"modified":1555026949000,"deprecated":false,"name":"Fanconi anemia group F protein","accession":"Q9NPI8","gene":"FANCF","description":"DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.5806852674233618,"antibodyCount":130,"monoclonalCount":9,"pubmedCount":null,"jensenScore":37.152064,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.47890624197986,"pubTatorScore":1.6486046889424664,"self":"https://pharos.nih.gov/idg/api/v1/targets(19907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/publications"},"_namespace":null},{"id":19908,"version":3,"created":1555026950000,"modified":1555045554000,"deprecated":false,"name":"Inward rectifier potassium channel 16","accession":"Q9NPI9","gene":"KCNJ16","description":"Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.5896680834514179,"antibodyCount":122,"monoclonalCount":2,"pubmedCount":null,"jensenScore":33.642169,"patentCount":1927,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.99477868677694,"pubTatorScore":1.3439709216140763,"self":"https://pharos.nih.gov/idg/api/v1/targets(19908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/properties"},"_links":{"count":904,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/publications"},"_namespace":null},{"id":19909,"version":2,"created":1555026958000,"modified":1555026961000,"deprecated":false,"name":"Zinc finger protein 469","accession":"Q96JG9","gene":"ZNF469","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.2571805592844492,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.578678,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.32643111077612,"pubTatorScore":1.3707152383608283,"self":"https://pharos.nih.gov/idg/api/v1/targets(19909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/publications"},"_namespace":null},{"id":19910,"version":3,"created":1555026962000,"modified":1555045556000,"deprecated":false,"name":"Mitochondrial intermembrane space import and assembly protein 40","accession":"Q8N4Q1","gene":"CHCHD4","description":"Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS) (PubMed:16185709, PubMed:19182799, PubMed:21059946). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria (PubMed:16185709, PubMed:19182799, PubMed:21059946). The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.842140857259102,"antibodyCount":108,"monoclonalCount":7,"pubmedCount":null,"jensenScore":70.612708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":51,"knowledgeAvailability":31.223721060253652,"pubTatorScore":1.6929870513363883,"self":"https://pharos.nih.gov/idg/api/v1/targets(19910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/publications"},"_namespace":null},{"id":19911,"version":3,"created":1555026966000,"modified":1555045557000,"deprecated":false,"name":"Prostaglandin reductase 3","accession":"Q8N4Q0","gene":"ZADH2","description":"Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. 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Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5593599176280937,"antibodyCount":127,"monoclonalCount":18,"pubmedCount":null,"jensenScore":33.675574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.501448216115357,"pubTatorScore":1.487290380234421,"self":"https://pharos.nih.gov/idg/api/v1/targets(20011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/properties"},"_links":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/publications"},"_namespace":null},{"id":20012,"version":3,"created":1555027556000,"modified":1555045620000,"deprecated":false,"name":"ATP synthase mitochondrial F1 complex assembly factor 2","accession":"Q8N5M1","gene":"ATPAF2","description":"May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1550598857613392,"antibodyCount":85,"monoclonalCount":21,"pubmedCount":null,"jensenScore":13.842893,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":36.2073731941181,"pubTatorScore":0.865301406361885,"self":"https://pharos.nih.gov/idg/api/v1/targets(20012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/publications"},"_namespace":null},{"id":20013,"version":2,"created":1555027561000,"modified":1555027565000,"deprecated":false,"name":"Huntingtin-associated protein 1","accession":"P54257","gene":"HAP1","description":"Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9179262349779131,"antibodyCount":162,"monoclonalCount":29,"pubmedCount":null,"jensenScore":84.129009,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.730187099772515,"pubTatorScore":2.062077353064466,"self":"https://pharos.nih.gov/idg/api/v1/targets(20013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/publications"},"_namespace":null},{"id":20014,"version":3,"created":1555027566000,"modified":1555045624000,"deprecated":false,"name":"Tetratricopeptide repeat protein 9C","accession":"Q8N5M4","gene":"TTC9C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0413926851582251,"antibodyCount":82,"monoclonalCount":6,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":43,"knowledgeAvailability":28.982828623164348,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(20014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/publications"},"_namespace":null},{"id":20015,"version":3,"created":1555027570000,"modified":1555045625000,"deprecated":false,"name":"Calcium-binding and spermatid-specific protein 1","accession":"Q96KC9","gene":"CABS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.5692675474187776,"antibodyCount":47,"monoclonalCount":3,"pubmedCount":null,"jensenScore":37.51425,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":16.627559198524416,"pubTatorScore":1.1383026981662814,"self":"https://pharos.nih.gov/idg/api/v1/targets(20015)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/properties"},"_links":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/publications"},"_namespace":null},{"id":20016,"version":3,"created":1555027572000,"modified":1555045627000,"deprecated":false,"name":"Ataxin-3","accession":"P54252","gene":"ATXN3","description":"Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8920679378278944,"antibodyCount":230,"monoclonalCount":17,"pubmedCount":null,"jensenScore":773.713129,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.942859152410264,"pubTatorScore":2.950504192835873,"self":"https://pharos.nih.gov/idg/api/v1/targets(20016)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(20016)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(20016)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(20016)/synonyms"},"_publications":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(20016)/publications"},"_namespace":null},{"id":20017,"version":3,"created":1555027579000,"modified":1555045629000,"deprecated":false,"name":"DnaJ homolog subfamily C member 1","accession":"Q96KC8","gene":"DNAJC1","description":"May modulate protein synthesis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.9138768887221739,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":8.410656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.21089197806025,"pubTatorScore":0.8853028577892053,"self":"https://pharos.nih.gov/idg/api/v1/targets(20017)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(20017)/properties"},"_links":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(20017)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(20017)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(20017)/publications"},"_namespace":null},{"id":20018,"version":3,"created":1555027587000,"modified":1555045630000,"deprecated":false,"name":"Ataxin-1","accession":"P54253","gene":"ATXN1","description":"Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.293703064293943,"antibodyCount":610,"monoclonalCount":269,"pubmedCount":null,"jensenScore":203.416242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":51.641157225558956,"pubTatorScore":2.6160247691170517,"self":"https://pharos.nih.gov/idg/api/v1/targets(20018)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":510,"href":"https://pharos.nih.gov/idg/api/v1/targets(20018)/properties"},"_links":{"count":1163,"href":"https://pharos.nih.gov/idg/api/v1/targets(20018)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(20018)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(20018)/publications"},"_namespace":null},{"id":20019,"version":2,"created":1555027596000,"modified":1555027597000,"deprecated":false,"name":"Testis-specific Y-encoded protein 2","accession":"A6NKD2","gene":"TSPY2","description":"Unknown. May be involved in sperm differentiation and proliferation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2575643010556633,"antibodyCount":13,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.612637,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.252385024229489,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(20019)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(20019)/properties"},"_links":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(20019)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(20019)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(20019)/publications"},"_namespace":null},{"id":20020,"version":2,"created":1555027597000,"modified":1555027600000,"deprecated":false,"name":"Protein jagunal homolog 1","accession":"Q8N5M9","gene":"JAGN1","description":"Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. 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Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.517839730542383,"antibodyCount":116,"monoclonalCount":2,"pubmedCount":null,"jensenScore":32.660954,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":35.94991916181057,"pubTatorScore":0.7563280378221116,"self":"https://pharos.nih.gov/idg/api/v1/targets(20046)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/publications"},"_namespace":null},{"id":20047,"version":3,"created":1555027760000,"modified":1555045654000,"deprecated":false,"name":"Butyrophilin-like protein 8","accession":"Q6UX41","gene":"BTNL8","description":"May stimulate primary immune response. 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The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.083097249253839,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":132.256287,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.66835930927873,"pubTatorScore":2.1750014146881456,"self":"https://pharos.nih.gov/idg/api/v1/targets(20072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":526,"href":"https://pharos.nih.gov/idg/api/v1/targets(20072)/properties"},"_links":{"count":1065,"href":"https://pharos.nih.gov/idg/api/v1/targets(20072)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(20072)/synonyms"},"_publications":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(20072)/publications"},"_namespace":null},{"id":20073,"version":2,"created":1555027906000,"modified":1555027906000,"deprecated":false,"name":"G antigen 2B/2C","accession":"Q13066","gene":"GAGE2B","description":"Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3627803788680325,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.290724,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.97636240419172,"pubTatorScore":0.08218663638195926,"self":"https://pharos.nih.gov/idg/api/v1/targets(20073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(20073)/properties"},"_links":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(20073)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(20073)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(20073)/publications"},"_namespace":null},{"id":20074,"version":2,"created":1555027906000,"modified":1555027915000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase CYLD","accession":"Q9NQC7","gene":"CYLD","description":"Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. 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After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. 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Endogenous Pol proteins may have kept, lost or modified their original function during evolution.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(20191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/publications"},"_namespace":null},{"id":20192,"version":3,"created":1555028711000,"modified":1555045756000,"deprecated":false,"name":"Translin","accession":"Q15631","gene":"TSN","description":"Exhibits both single-stranded and double-stranded endoribonuclease activity. 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May play a role in ocular development and astrocyte function (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1081390883318016,"antibodyCount":125,"monoclonalCount":4,"pubmedCount":null,"jensenScore":12.525263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.99213045282007,"pubTatorScore":0.9348389863714794,"self":"https://pharos.nih.gov/idg/api/v1/targets(20242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/publications"},"_namespace":null},{"id":20243,"version":2,"created":1555029641000,"modified":1555029647000,"deprecated":false,"name":"Activating signal cointegrator 1","accession":"Q15650","gene":"TRIP4","description":"Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. 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Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.315834428211756,"antibodyCount":157,"monoclonalCount":5,"pubmedCount":null,"jensenScore":207.284766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.979606774431254,"pubTatorScore":1.6783882715119793,"self":"https://pharos.nih.gov/idg/api/v1/targets(1044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/publications"},"_namespace":null},{"id":1045,"version":2,"created":1554861939000,"modified":1554861939000,"deprecated":false,"name":"Putative WAS protein family homolog 4","accession":"A8MWX3","gene":"WASH4P","description":"May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.57316843100489,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1045)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/properties"},"_links":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/publications"},"_namespace":null},{"id":1046,"version":3,"created":1554861940000,"modified":1555032994000,"deprecated":false,"name":"Cathepsin E","accession":"P14091","gene":"CTSE","description":"May have a role in immune function. 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DCX(DTL) directs autoubiquitination of DTL.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9219918462378247,"antibodyCount":276,"monoclonalCount":14,"pubmedCount":null,"jensenScore":80.081602,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":41.552163791548374,"pubTatorScore":1.8199261307098191,"self":"https://pharos.nih.gov/idg/api/v1/targets(1065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/publications"},"_namespace":null},{"id":1066,"version":3,"created":1554862056000,"modified":1555033008000,"deprecated":false,"name":"Cullin-3","accession":"Q13618","gene":"CUL3","description":"Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.263221168171643,"antibodyCount":307,"monoclonalCount":34,"pubmedCount":null,"jensenScore":1670.770098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":48.46669585230958,"pubTatorScore":2.127632845068227,"self":"https://pharos.nih.gov/idg/api/v1/targets(1066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/properties"},"_links":{"count":1298,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/publications"},"_namespace":null},{"id":1067,"version":3,"created":1554862061000,"modified":1555033010000,"deprecated":false,"name":"Cullin-2","accession":"Q13617","gene":"CUL2","description":"Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9984363182115807,"antibodyCount":373,"monoclonalCount":13,"pubmedCount":null,"jensenScore":95.098475,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":40.8626395934268,"pubTatorScore":1.973342060409126,"self":"https://pharos.nih.gov/idg/api/v1/targets(1067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/properties"},"_links":{"count":1155,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/publications"},"_namespace":null},{"id":1068,"version":3,"created":1554862065000,"modified":1555033012000,"deprecated":false,"name":"Cullin-1","accession":"Q13616","gene":"CUL1","description":"Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.379310234214266,"antibodyCount":416,"monoclonalCount":57,"pubmedCount":null,"jensenScore":182.586086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":47.959506528255524,"pubTatorScore":2.206510423237846,"self":"https://pharos.nih.gov/idg/api/v1/targets(1068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":683,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/properties"},"_links":{"count":1175,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/synonyms"},"_publications":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/publications"},"_namespace":null},{"id":1069,"version":3,"created":1554862070000,"modified":1555033017000,"deprecated":false,"name":"Secretoglobin family 1D member 4","accession":"Q6XE38","gene":"SCGB1D4","description":"Seems to be involved in the regulation of chemotactic cell migration and invasion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.906494265974766,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":797.499692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":7.466500657428454,"pubTatorScore":0.7696234303982586,"self":"https://pharos.nih.gov/idg/api/v1/targets(1069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/properties"},"_links":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/publications"},"_namespace":null},{"id":1070,"version":3,"created":1554862070000,"modified":1555033017000,"deprecated":false,"name":"m-AAA protease-interacting protein 1, mitochondrial","accession":"Q8WWC4","gene":"MAIP1","description":"Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation (PubMed:27642048). Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/publications"},"_namespace":null},{"id":1071,"version":2,"created":1554862073000,"modified":1554862075000,"deprecated":false,"name":"UHRF1-binding protein 1","accession":"Q6BDS2","gene":"UHRF1BP1","description":"May act as a negative regulator of cell growth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.303306181101351,"antibodyCount":34,"monoclonalCount":1,"pubmedCount":null,"jensenScore":21.973611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.658921808217926,"pubTatorScore":1.174053902676185,"self":"https://pharos.nih.gov/idg/api/v1/targets(1071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/publications"},"_namespace":null},{"id":1072,"version":4,"created":1554862076000,"modified":1555033020000,"deprecated":false,"name":"Estradiol 17-beta-dehydrogenase 1","accession":"P14061","gene":"HSD17B1","description":"Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3631461666679403,"antibodyCount":198,"monoclonalCount":30,"pubmedCount":null,"jensenScore":220.756662,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":36.330906660087166,"pubTatorScore":2.305999068587153,"self":"https://pharos.nih.gov/idg/api/v1/targets(1072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/properties"},"_links":{"count":1161,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/links"},"_synonyms":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/publications"},"_namespace":null},{"id":1073,"version":3,"created":1554862176000,"modified":1555033022000,"deprecated":false,"name":"B-lymphocyte antigen CD19","accession":"P15391","gene":"CD19","description":"Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.543345545351551,"antibodyCount":2794,"monoclonalCount":2211,"pubmedCount":null,"jensenScore":3206.228073,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.87163856964033,"pubTatorScore":3.31740018866786,"self":"https://pharos.nih.gov/idg/api/v1/targets(1073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/synonyms"},"_publications":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/publications"},"_namespace":null},{"id":1074,"version":2,"created":1554862182000,"modified":1554862189000,"deprecated":false,"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","accession":"P14060","gene":"HSD3B1","description":"3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.621474918455086,"antibodyCount":267,"monoclonalCount":72,"pubmedCount":null,"jensenScore":370.748747,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.755208701969554,"pubTatorScore":2.630020544684237,"self":"https://pharos.nih.gov/idg/api/v1/targets(1074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/properties"},"_links":{"count":534,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/publications"},"_namespace":null},{"id":1075,"version":2,"created":1554862190000,"modified":1554862191000,"deprecated":false,"name":"Arrestin domain-containing protein 5","accession":"A6NEK1","gene":"ARRDC5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.174496124948186,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/properties"},"_links":{"count":679,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/publications"},"_namespace":null},{"id":1076,"version":3,"created":1554862192000,"modified":1555033026000,"deprecated":false,"name":"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase","accession":"Q9UK23","gene":"NAGPA","description":"Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. 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Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.3580393160731954,"antibodyCount":394,"monoclonalCount":85,"pubmedCount":null,"jensenScore":229.463476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.57475273163292,"pubTatorScore":2.266578219979825,"self":"https://pharos.nih.gov/idg/api/v1/targets(1176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/properties"},"_links":{"count":1253,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/synonyms"},"_publications":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/publications"},"_namespace":null},{"id":1177,"version":3,"created":1554862980000,"modified":1555033137000,"deprecated":false,"name":"CCA tRNA nucleotidyltransferase 1, mitochondrial","accession":"Q96Q11","gene":"TRNT1","description":"Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.381716610823494,"antibodyCount":33,"monoclonalCount":7,"pubmedCount":null,"jensenScore":23.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.357360006346454,"pubTatorScore":0.9720999474776685,"self":"https://pharos.nih.gov/idg/api/v1/targets(1177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/publications"},"_namespace":null},{"id":1178,"version":2,"created":1554862984000,"modified":1554862987000,"deprecated":false,"name":"Paired box protein Pax-2","accession":"Q02962","gene":"PAX2","description":"Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). 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Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8357319291536378,"antibodyCount":233,"monoclonalCount":113,"pubmedCount":null,"jensenScore":76.496361,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.33086810950227,"pubTatorScore":1.7647755980037256,"self":"https://pharos.nih.gov/idg/api/v1/targets(1182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/publications"},"_namespace":null},{"id":1183,"version":2,"created":1554863000000,"modified":1554863002000,"deprecated":false,"name":"Extracellular tyrosine-protein kinase PKDCC","accession":"Q504Y2","gene":"PKDCC","description":"Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. 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May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.1595099255539152,"antibodyCount":51,"monoclonalCount":3,"pubmedCount":null,"jensenScore":16.188545,"patentCount":3622,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.829039426124186,"pubTatorScore":0.5576409584427934,"self":"https://pharos.nih.gov/idg/api/v1/targets(1183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/publications"},"_namespace":null},{"id":1184,"version":3,"created":1554863003000,"modified":1555033141000,"deprecated":false,"name":"Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase","accession":"O43173","gene":"ST8SIA3","description":"Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. 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It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.05924312590313,"antibodyCount":57,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.120137,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":28.822846920582478,"pubTatorScore":0.8507019119643774,"self":"https://pharos.nih.gov/idg/api/v1/targets(1184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/properties"},"_links":{"count":680,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/publications"},"_namespace":null},{"id":1185,"version":2,"created":1554863005000,"modified":1554863015000,"deprecated":false,"name":"Serine protease hepsin","accession":"P05981","gene":"HPN","description":"Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). 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Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.500227716062851,"antibodyCount":125,"monoclonalCount":22,"pubmedCount":null,"jensenScore":315.982718,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.53240540444839,"pubTatorScore":1.944366803706657,"self":"https://pharos.nih.gov/idg/api/v1/targets(1185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/publications"},"_namespace":null},{"id":1186,"version":3,"created":1554863016000,"modified":1555033143000,"deprecated":false,"name":"U4/U6 small nuclear ribonucleoprotein Prp4","accession":"O43172","gene":"PRPF4","description":"Participates in pre-mRNA splicing. 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Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7413028682464202,"antibodyCount":210,"monoclonalCount":125,"pubmedCount":null,"jensenScore":57.505777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":35.068155386655356,"pubTatorScore":1.5667328534088603,"self":"https://pharos.nih.gov/idg/api/v1/targets(1507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/publications"},"_namespace":null},{"id":1508,"version":3,"created":1554865763000,"modified":1555033362000,"deprecated":false,"name":"Intelectin-2","accession":"Q8WWU7","gene":"ITLN2","description":"May play a role in the defense system against pathogens.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8818801400749041,"antibodyCount":88,"monoclonalCount":4,"pubmedCount":null,"jensenScore":7.688034,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":11.645890037202406,"pubTatorScore":1.5667647455862992,"self":"https://pharos.nih.gov/idg/api/v1/targets(1508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/properties"},"_links":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/publications"},"_namespace":null},{"id":1509,"version":2,"created":1554865765000,"modified":1554865768000,"deprecated":false,"name":"Sperm-associated antigen 5","accession":"Q96R06","gene":"SPAG5","description":"Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7274272115070566,"antibodyCount":136,"monoclonalCount":23,"pubmedCount":null,"jensenScore":51.399863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.86370395045702,"pubTatorScore":1.528947279700076,"self":"https://pharos.nih.gov/idg/api/v1/targets(1509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/publications"},"_namespace":null},{"id":1510,"version":3,"created":1554865768000,"modified":1555033363000,"deprecated":false,"name":"Cbp/p300-interacting transactivator 2","accession":"Q99967","gene":"CITED2","description":"Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.077598957112513,"antibodyCount":167,"monoclonalCount":23,"pubmedCount":null,"jensenScore":134.770186,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":47.57652001359431,"pubTatorScore":1.7429530643034703,"self":"https://pharos.nih.gov/idg/api/v1/targets(1510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/publications"},"_namespace":null},{"id":1511,"version":3,"created":1554865773000,"modified":1555033364000,"deprecated":false,"name":"CST complex subunit TEN1","accession":"Q86WV5","gene":"TEN1","description":"Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1818176700234755,"antibodyCount":8,"monoclonalCount":1,"pubmedCount":null,"jensenScore":142.00577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":23.43799046602949,"pubTatorScore":1.8735535525615976,"self":"https://pharos.nih.gov/idg/api/v1/targets(1511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/publications"},"_namespace":null},{"id":1512,"version":2,"created":1554865775000,"modified":1554865775000,"deprecated":false,"name":"Putative zinc finger protein 840","accession":"A6NDX5","gene":"ZNF840P","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.5821605842651665,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1512)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/publications"},"_namespace":null},{"id":1513,"version":2,"created":1554865775000,"modified":1554865778000,"deprecated":false,"name":"UDP-N-acetylhexosamine pyrophosphorylase-like protein 1","accession":"Q3KQV9","gene":"UAP1L1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":70,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.814584628465838,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(1513)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/publications"},"_namespace":null},{"id":1514,"version":3,"created":1554865778000,"modified":1555033366000,"deprecated":false,"name":"REM2- and Rab-like small GTPase 1","accession":"Q9BU20","gene":"RSG1","description":"Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.3292525852599708,"antibodyCount":31,"monoclonalCount":10,"pubmedCount":null,"jensenScore":22.174481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.464783687543033,"pubTatorScore":0.9879427492076456,"self":"https://pharos.nih.gov/idg/api/v1/targets(1514)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/publications"},"_namespace":null},{"id":1515,"version":3,"created":1554865781000,"modified":1555033368000,"deprecated":false,"name":"Src kinase-associated phosphoprotein 1","accession":"Q86WV1","gene":"SKAP1","description":"Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3152731882143351,"antibodyCount":175,"monoclonalCount":34,"pubmedCount":null,"jensenScore":25.178416,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":49,"knowledgeAvailability":32.57898703245089,"pubTatorScore":1.3528930792475478,"self":"https://pharos.nih.gov/idg/api/v1/targets(1515)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/publications"},"_namespace":null},{"id":1516,"version":2,"created":1554865784000,"modified":1554865786000,"deprecated":false,"name":"Lipase maturation factor 2","accession":"Q9BU23","gene":"LMF2","description":"Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.2218487496163564,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.895238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.928839689302183,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(1516)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/publications"},"_namespace":null},{"id":1517,"version":2,"created":1554865787000,"modified":1554865790000,"deprecated":false,"name":"Hairy/enhancer-of-split related with YRPW motif protein 1","accession":"Q9Y5J3","gene":"HEY1","description":"Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2839782827565593,"antibodyCount":335,"monoclonalCount":215,"pubmedCount":null,"jensenScore":163.387144,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.75704237386846,"pubTatorScore":2.1845728579159287,"self":"https://pharos.nih.gov/idg/api/v1/targets(1517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/publications"},"_namespace":null},{"id":1518,"version":2,"created":1554865790000,"modified":1554865793000,"deprecated":false,"name":"Calbindin","accession":"P05937","gene":"CALB1","description":"Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.319564764438253,"antibodyCount":287,"monoclonalCount":63,"pubmedCount":null,"jensenScore":2149.899918,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.17439596731848,"pubTatorScore":2.185615613250135,"self":"https://pharos.nih.gov/idg/api/v1/targets(1518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/publications"},"_namespace":null},{"id":1519,"version":2,"created":1554865794000,"modified":1554865796000,"deprecated":false,"name":"Pleckstrin homology-like domain family A member 3","accession":"Q9Y5J5","gene":"PHLDA3","description":"p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. 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Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. 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Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). 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Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8646529587057563,"antibodyCount":34,"monoclonalCount":1,"pubmedCount":null,"jensenScore":69.531214,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.944479381616944,"pubTatorScore":1.8458262497457494,"self":"https://pharos.nih.gov/idg/api/v1/targets(1601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/publications"},"_namespace":null},{"id":1602,"version":3,"created":1554866047000,"modified":1555033427000,"deprecated":false,"name":"Sialidase-4","accession":"Q8WWR8","gene":"NEU4","description":"May function in lysosomal catabolism of sialylated glycoconjugates. 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Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.3962404697813218,"antibodyCount":115,"monoclonalCount":0,"pubmedCount":null,"jensenScore":25.106124,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":24.243851462563175,"pubTatorScore":1.2978220518458632,"self":"https://pharos.nih.gov/idg/api/v1/targets(1602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/publications"},"_namespace":null},{"id":1603,"version":2,"created":1554866051000,"modified":1554866052000,"deprecated":false,"name":"Opiorphin prepropeptide","accession":"Q99935","gene":"OPRPN","description":"Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. 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Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5025174626326296,"antibodyCount":394,"monoclonalCount":80,"pubmedCount":null,"jensenScore":335.071387,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.455514125649835,"pubTatorScore":2.3654156744559964,"self":"https://pharos.nih.gov/idg/api/v1/targets(1605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":512,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/properties"},"_links":{"count":1189,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/publications"},"_namespace":null},{"id":1606,"version":2,"created":1554866061000,"modified":1554866063000,"deprecated":false,"name":"Ras-related protein Rab-39A","accession":"Q14964","gene":"RAB39A","description":"Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. 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The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9018666536966495,"antibodyCount":281,"monoclonalCount":50,"pubmedCount":null,"jensenScore":84.509388,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":46.3480326011813,"pubTatorScore":2.134983651676906,"self":"https://pharos.nih.gov/idg/api/v1/targets(1666)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":564,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/properties"},"_links":{"count":1129,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/synonyms"},"_publications":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/publications"},"_namespace":null},{"id":1667,"version":2,"created":1554866385000,"modified":1554866391000,"deprecated":false,"name":"Transient receptor potential cation channel subfamily M member 2","accession":"O94759","gene":"TRPM2","description":"Isoform 3: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.3431812562907204,"antibodyCount":209,"monoclonalCount":2,"pubmedCount":null,"jensenScore":25.136394,"patentCount":17620,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.32165052899715,"pubTatorScore":2.2813679747644464,"self":"https://pharos.nih.gov/idg/api/v1/targets(1667)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/publications"},"_namespace":null},{"id":1668,"version":3,"created":1554866392000,"modified":1555033482000,"deprecated":false,"name":"Opioid-binding protein/cell adhesion molecule","accession":"Q14982","gene":"OPCML","description":"Binds opioids in the presence of acidic lipids; probably involved in cell contact.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6591449871542372,"antibodyCount":163,"monoclonalCount":4,"pubmedCount":null,"jensenScore":52.217845,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.30984320765463,"pubTatorScore":1.6459029107299965,"self":"https://pharos.nih.gov/idg/api/v1/targets(1668)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/publications"},"_namespace":null},{"id":1669,"version":3,"created":1554866395000,"modified":1555033483000,"deprecated":false,"name":"Interleukin-10 receptor subunit alpha","accession":"Q13651","gene":"IL10RA","description":"Receptor for IL10; binds IL10 with a high affinity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0822194018828557,"antibodyCount":599,"monoclonalCount":285,"pubmedCount":null,"jensenScore":94.930674,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.86502916142436,"pubTatorScore":2.1407042325740395,"self":"https://pharos.nih.gov/idg/api/v1/targets(1669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/publications"},"_namespace":null},{"id":1670,"version":2,"created":1554866399000,"modified":1554866399000,"deprecated":false,"name":"Putative uncharacterized protein SHANK2-AS3","accession":"Q9BTD1","gene":"SHANK2-AS3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.117805997054004,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/links"},"_synonyms":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/publications"},"_namespace":null},{"id":1671,"version":2,"created":1554866399000,"modified":1554866403000,"deprecated":false,"name":"Nuclear mitotic apparatus protein 1","accession":"Q14980","gene":"NUMA1","description":"Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.765437163511179,"antibodyCount":235,"monoclonalCount":56,"pubmedCount":null,"jensenScore":575.768376,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.44427868551381,"pubTatorScore":2.643643026504928,"self":"https://pharos.nih.gov/idg/api/v1/targets(1671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":599,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/properties"},"_links":{"count":1289,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/synonyms"},"_publications":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/publications"},"_namespace":null},{"id":1672,"version":2,"created":1554866404000,"modified":1554866407000,"deprecated":false,"name":"Unconventional prefoldin RPB5 interactor 1","accession":"O94763","gene":"URI1","description":"Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.154092445493425,"antibodyCount":150,"monoclonalCount":16,"pubmedCount":null,"jensenScore":134.791463,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.96142243072948,"pubTatorScore":1.2803289891664442,"self":"https://pharos.nih.gov/idg/api/v1/targets(1672)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/publications"},"_namespace":null},{"id":1673,"version":2,"created":1554866408000,"modified":1554866410000,"deprecated":false,"name":"Gasdermin-A","accession":"Q96QA5","gene":"GSDMA","description":"May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4440059578306288,"antibodyCount":77,"monoclonalCount":1,"pubmedCount":null,"jensenScore":26.68852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.98311739648423,"pubTatorScore":0.8766438984987317,"self":"https://pharos.nih.gov/idg/api/v1/targets(1673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/publications"},"_namespace":null},{"id":1674,"version":3,"created":1554866411000,"modified":1555033484000,"deprecated":false,"name":"Nuclear cap-binding protein subunit 2","accession":"P52298","gene":"NCBP2","description":"Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4509879049559327,"antibodyCount":110,"monoclonalCount":16,"pubmedCount":null,"jensenScore":24.215146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.374749820387784,"pubTatorScore":1.4098794500040757,"self":"https://pharos.nih.gov/idg/api/v1/targets(1674)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/publications"},"_namespace":null},{"id":1675,"version":2,"created":1554866414000,"modified":1554866417000,"deprecated":false,"name":"ATP-dependent DNA helicase Q4","accession":"O94761","gene":"RECQL4","description":"DNA-dependent ATPase. May modulate chromosome segregation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.559291830879104,"pubTatorScore":2.1315063555170557,"self":"https://pharos.nih.gov/idg/api/v1/targets(1675)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/properties"},"_links":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/publications"},"_namespace":null},{"id":1676,"version":2,"created":1554866417000,"modified":1554866420000,"deprecated":false,"name":"ATP-dependent DNA helicase Q5","accession":"O94762","gene":"RECQL5","description":"Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6737272392684617,"antibodyCount":148,"monoclonalCount":3,"pubmedCount":null,"jensenScore":56.213067,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.25735231303438,"pubTatorScore":1.702072155989254,"self":"https://pharos.nih.gov/idg/api/v1/targets(1676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/publications"},"_namespace":null},{"id":1677,"version":3,"created":1554866421000,"modified":1555033486000,"deprecated":false,"name":"Serine/threonine-protein kinase 17B","accession":"O94768","gene":"STK17B","description":"Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.2692278149360092,"antibodyCount":344,"monoclonalCount":29,"pubmedCount":null,"jensenScore":26.593893,"patentCount":3914,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.78907398232207,"pubTatorScore":1.1890399805288363,"self":"https://pharos.nih.gov/idg/api/v1/targets(1677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/publications"},"_namespace":null},{"id":1678,"version":3,"created":1554866428000,"modified":1555033487000,"deprecated":false,"name":"Importin subunit alpha-5","accession":"P52294","gene":"KPNA1","description":"Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9509188792196084,"antibodyCount":284,"monoclonalCount":61,"pubmedCount":null,"jensenScore":85.30549,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.92514477718884,"pubTatorScore":1.8022111240896899,"self":"https://pharos.nih.gov/idg/api/v1/targets(1678)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":494,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/properties"},"_links":{"count":1135,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/publications"},"_namespace":null},{"id":1679,"version":2,"created":1554866433000,"modified":1554866435000,"deprecated":false,"name":"Pro-neuregulin-4, membrane-bound isoform","accession":"Q8WWG1","gene":"NRG4","description":"Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. 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Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.8885341684905472,"antibodyCount":271,"monoclonalCount":7,"pubmedCount":null,"jensenScore":73.305966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":46.47741139574961,"pubTatorScore":1.782535169534217,"self":"https://pharos.nih.gov/idg/api/v1/targets(1753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/publications"},"_namespace":null},{"id":1754,"version":3,"created":1554867369000,"modified":1555033543000,"deprecated":false,"name":"CCAAT/enhancer-binding protein gamma","accession":"P53567","gene":"CEBPG","description":"Transcription factor that binds to the promoter and the enhancer regions of target genes. 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Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6446026982283284,"antibodyCount":288,"monoclonalCount":30,"pubmedCount":null,"jensenScore":44.909003,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.50773135346582,"pubTatorScore":1.5878178197368258,"self":"https://pharos.nih.gov/idg/api/v1/targets(1757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/publications"},"_namespace":null},{"id":1758,"version":3,"created":1554867378000,"modified":1555033547000,"deprecated":false,"name":"Dickkopf-like protein 1","accession":"Q9UK85","gene":"DKKL1","description":"Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. 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M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also involved in haematopoietic stem cells specification: acts by binding to m6A-containing mRNAs, leading to decrease Notch dignaling and promote endothelial to haematopoietic transition (By similarity). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.379291824010017,"antibodyCount":88,"monoclonalCount":1,"pubmedCount":null,"jensenScore":18.02342,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.718264373428546,"pubTatorScore":1.0443903969872081,"self":"https://pharos.nih.gov/idg/api/v1/targets(1760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/publications"},"_namespace":null},{"id":1761,"version":3,"created":1554867385000,"modified":1555033548000,"deprecated":false,"name":"DNA (cytosine-5)-methyltransferase 3-like","accession":"Q9UJW3","gene":"DNMT3L","description":"Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). 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While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.955550008303641,"antibodyCount":403,"monoclonalCount":104,"pubmedCount":null,"jensenScore":87.16905,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.831556841143634,"pubTatorScore":1.763790545473362,"self":"https://pharos.nih.gov/idg/api/v1/targets(1761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/properties"},"_links":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/publications"},"_namespace":null},{"id":1762,"version":3,"created":1554867387000,"modified":1555033550000,"deprecated":false,"name":"Tubulointerstitial nephritis antigen","accession":"Q9UJW2","gene":"TINAG","description":"Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. 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Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0845632275812305,"antibodyCount":103,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1172.785159,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.35503458029925,"pubTatorScore":2.283008510599602,"self":"https://pharos.nih.gov/idg/api/v1/targets(1895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/properties"},"_links":{"count":1141,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/publications"},"_namespace":null},{"id":1896,"version":2,"created":1554868175000,"modified":1554868176000,"deprecated":false,"name":"Serpin B12","accession":"Q96P63","gene":"SERPINB12","description":"Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5662410275720295,"antibodyCount":155,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.274038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.545477131162176,"pubTatorScore":0.3937839653827023,"self":"https://pharos.nih.gov/idg/api/v1/targets(1896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/properties"},"_links":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/publications"},"_namespace":null},{"id":1897,"version":2,"created":1554868176000,"modified":1554868180000,"deprecated":false,"name":"Desmin","accession":"P17661","gene":"DES","description":"Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5606845203649036,"antibodyCount":991,"monoclonalCount":388,"pubmedCount":null,"jensenScore":36.649415,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.35528068136759,"pubTatorScore":3.3294745230310103,"self":"https://pharos.nih.gov/idg/api/v1/targets(1897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/properties"},"_links":{"count":1122,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/publications"},"_namespace":null},{"id":1898,"version":2,"created":1554868181000,"modified":1554868182000,"deprecated":false,"name":"Zona pellucida-binding protein 1","accession":"Q9BS86","gene":"ZPBP","description":"Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.4404107771381454,"antibodyCount":43,"monoclonalCount":4,"pubmedCount":null,"jensenScore":27.125969,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.19633908405359,"pubTatorScore":0.18225169009695621,"self":"https://pharos.nih.gov/idg/api/v1/targets(1898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/properties"},"_links":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/publications"},"_namespace":null},{"id":1899,"version":2,"created":1554868183000,"modified":1554868184000,"deprecated":false,"name":"Shadow of prion protein","accession":"Q5BIV9","gene":"SPRN","description":"Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.496975112399225,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":315.102369,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.954515739352754,"pubTatorScore":1.4110582111071686,"self":"https://pharos.nih.gov/idg/api/v1/targets(1899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/properties"},"_links":{"count":724,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/publications"},"_namespace":null},{"id":1900,"version":3,"created":1554868185000,"modified":1555033635000,"deprecated":false,"name":"5'-AMP-activated protein kinase catalytic subunit alpha-2","accession":"P54646","gene":"PRKAA2","description":"Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.4270543185885953,"antibodyCount":603,"monoclonalCount":90,"pubmedCount":null,"jensenScore":21.129602,"patentCount":2708,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":48.25519974994137,"pubTatorScore":2.891633918314638,"self":"https://pharos.nih.gov/idg/api/v1/targets(1900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":611,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/properties"},"_links":{"count":1080,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/synonyms"},"_publications":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/publications"},"_namespace":null},{"id":1901,"version":3,"created":1554868189000,"modified":1554868312000,"deprecated":false,"name":"Non-lysosomal glucosylceramidase","accession":"Q9HCG7","gene":"GBA2","description":"Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.623300071077421,"antibodyCount":59,"monoclonalCount":3,"pubmedCount":null,"jensenScore":43.136831,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.89649267724086,"pubTatorScore":1.3540404840396234,"self":"https://pharos.nih.gov/idg/api/v1/targets(1901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/publications"},"_namespace":null},{"id":1902,"version":2,"created":1554868313000,"modified":1554868316000,"deprecated":false,"name":"Zinc finger protein 160","accession":"Q9HCG1","gene":"ZNF160","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.6726109010774758,"antibodyCount":63,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.330555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.951730359231558,"pubTatorScore":0.7552394067648586,"self":"https://pharos.nih.gov/idg/api/v1/targets(1902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/publications"},"_namespace":null},{"id":1903,"version":4,"created":1554868316000,"modified":1555033639000,"deprecated":false,"name":"Calpain-2 catalytic subunit","accession":"P17655","gene":"CAPN2","description":"Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.6958534248572399,"antibodyCount":220,"monoclonalCount":53,"pubmedCount":null,"jensenScore":48.462233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":50.06881370779312,"pubTatorScore":2.38354695187271,"self":"https://pharos.nih.gov/idg/api/v1/targets(1903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":479,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/properties"},"_links":{"count":1308,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/publications"},"_namespace":null},{"id":1904,"version":3,"created":1554868368000,"modified":1555033642000,"deprecated":false,"name":"Cytoplasmic protein NCK1","accession":"P16333","gene":"NCK1","description":"Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.250320872878768,"antibodyCount":398,"monoclonalCount":108,"pubmedCount":null,"jensenScore":186.504647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":43.22202645658912,"pubTatorScore":2.104460373381725,"self":"https://pharos.nih.gov/idg/api/v1/targets(1904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":654,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/properties"},"_links":{"count":1167,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/synonyms"},"_publications":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/publications"},"_namespace":null},{"id":1905,"version":3,"created":1554868373000,"modified":1555033644000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 6","accession":"P17658","gene":"KCNA6","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.6067488398587335,"antibodyCount":86,"monoclonalCount":11,"pubmedCount":null,"jensenScore":36.750194,"patentCount":1758,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":30.935589263743452,"pubTatorScore":1.3313188207116937,"self":"https://pharos.nih.gov/idg/api/v1/targets(1905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/properties"},"_links":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/publications"},"_namespace":null},{"id":1906,"version":3,"created":1554868374000,"modified":1555033645000,"deprecated":false,"name":"WD repeat and FYVE domain-containing protein 2","accession":"Q96P53","gene":"WDFY2","description":"Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). 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Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5809701363981112,"antibodyCount":145,"monoclonalCount":2,"pubmedCount":null,"jensenScore":42.84336,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.08245698627497,"pubTatorScore":1.3853160214461315,"self":"https://pharos.nih.gov/idg/api/v1/targets(1910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/publications"},"_namespace":null},{"id":1911,"version":2,"created":1554868391000,"modified":1554868393000,"deprecated":false,"name":"MAGE-like protein 2","accession":"Q9UJ55","gene":"MAGEL2","description":"Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. 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PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. 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PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0725141484662384,"antibodyCount":293,"monoclonalCount":5,"pubmedCount":null,"jensenScore":114.434802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.12082519181108,"pubTatorScore":1.4844966654107528,"self":"https://pharos.nih.gov/idg/api/v1/targets(1919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/publications"},"_namespace":null},{"id":1920,"version":3,"created":1554868430000,"modified":1555033655000,"deprecated":false,"name":"Nuclear receptor subfamily 2 group E member 1","accession":"Q9Y466","gene":"NR2E1","description":"Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). 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Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7501937867821071,"antibodyCount":191,"monoclonalCount":138,"pubmedCount":null,"jensenScore":5.585444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.12953073623382,"pubTatorScore":0.3603263937362369,"self":"https://pharos.nih.gov/idg/api/v1/targets(1921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/publications"},"_namespace":null},{"id":1922,"version":3,"created":1554868435000,"modified":1555033656000,"deprecated":false,"name":"Elongation factor 1-delta","accession":"P29692","gene":"EEF1D","description":"Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4920389392750326,"antibodyCount":198,"monoclonalCount":16,"pubmedCount":null,"jensenScore":29.454816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":48.59641613646232,"pubTatorScore":1.554675836219506,"self":"https://pharos.nih.gov/idg/api/v1/targets(1922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/publications"},"_namespace":null},{"id":1923,"version":3,"created":1554868440000,"modified":1555033659000,"deprecated":false,"name":"Kinesin-like protein KIF22","accession":"Q14807","gene":"KIF22","description":"Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. 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Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6999615439352413,"antibodyCount":147,"monoclonalCount":60,"pubmedCount":null,"jensenScore":54.308317,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":45.4057832987793,"pubTatorScore":1.8641204972809182,"self":"https://pharos.nih.gov/idg/api/v1/targets(1923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/properties"},"_links":{"count":1180,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/publications"},"_namespace":null},{"id":1924,"version":2,"created":1554868444000,"modified":1554868447000,"deprecated":false,"name":"Homeobox protein MSX-1","accession":"P28360","gene":"MSX1","description":"Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5924493453394435,"antibodyCount":298,"monoclonalCount":79,"pubmedCount":null,"jensenScore":390.083512,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.990639124367526,"pubTatorScore":2.3705051364039837,"self":"https://pharos.nih.gov/idg/api/v1/targets(1924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/synonyms"},"_publications":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/publications"},"_namespace":null},{"id":1925,"version":3,"created":1554868448000,"modified":1555033660000,"deprecated":false,"name":"PHD finger protein 11","accession":"Q9UIL8","gene":"PHF11","description":"Positive regulator of Th1-type cytokine gene expression.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.1372747950743574,"antibodyCount":126,"monoclonalCount":7,"pubmedCount":null,"jensenScore":16.997296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.008292910844816,"pubTatorScore":1.5988993621042322,"self":"https://pharos.nih.gov/idg/api/v1/targets(1925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/publications"},"_namespace":null},{"id":1926,"version":3,"created":1554868451000,"modified":1555033662000,"deprecated":false,"name":"TBC1 domain family member 23","accession":"Q9NUY8","gene":"TBC1D23","description":"Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). 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Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6715051301219725,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.566822,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.049962351112715,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(1926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":393,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/publications"},"_namespace":null},{"id":1927,"version":2,"created":1554868454000,"modified":1554868456000,"deprecated":false,"name":"Dephospho-CoA kinase domain-containing 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histocompatibility antigen, B-35 alpha chain","accession":"P30685","gene":"HLA-B","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8875247029897861,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1613.472112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.7801564385417628,"self":"https://pharos.nih.gov/idg/api/v1/targets(1928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1938,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/properties"},"_links":{"count":1511,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/links"},"_synonyms":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/synonyms"},"_publications":{"count":1770,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/publications"},"_namespace":null},{"id":1929,"version":2,"created":1554868471000,"modified":1554868475000,"deprecated":false,"name":"40S ribosomal protein 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1","accession":"Q9HCN8","gene":"SDF2L1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5714542143758434,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.345171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.85386265611153,"pubTatorScore":0.3084626038558672,"self":"https://pharos.nih.gov/idg/api/v1/targets(1930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/publications"},"_namespace":null},{"id":1931,"version":2,"created":1554868480000,"modified":1554868484000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 2","accession":"P16389","gene":"KCNA2","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.5555023992097845,"antibodyCount":205,"monoclonalCount":29,"pubmedCount":null,"jensenScore":343.284659,"patentCount":41091,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.70590595579717,"pubTatorScore":2.308098234828824,"self":"https://pharos.nih.gov/idg/api/v1/targets(1931)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/publications"},"_namespace":null},{"id":1932,"version":4,"created":1554868485000,"modified":1555033668000,"deprecated":false,"name":"Serine/threonine-protein kinase B-raf","accession":"P15056","gene":"BRAF","description":"Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.3358160611629932,"antibodyCount":1431,"monoclonalCount":423,"pubmedCount":null,"jensenScore":220.931088,"patentCount":172202,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":61.272893015894574,"pubTatorScore":3.6376522024060898,"self":"https://pharos.nih.gov/idg/api/v1/targets(1932)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2494,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/properties"},"_links":{"count":4137,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/links"},"_synonyms":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/synonyms"},"_publications":{"count":1873,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/publications"},"_namespace":null},{"id":1933,"version":2,"created":1554868877000,"modified":1554868879000,"deprecated":false,"name":"Spermidine/spermine N(1)-acetyltransferase-like protein 1","accession":"Q86VE3","gene":"SATL1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.395749513234078,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1933)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/properties"},"_links":{"count":700,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/publications"},"_namespace":null},{"id":1934,"version":3,"created":1554868879000,"modified":1555033682000,"deprecated":false,"name":"GPN-loop GTPase 1","accession":"Q9HCN4","gene":"GPN1","description":"Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0513669594211132,"antibodyCount":136,"monoclonalCount":39,"pubmedCount":null,"jensenScore":11.296713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":37.65424320519641,"pubTatorScore":1.0498637880278818,"self":"https://pharos.nih.gov/idg/api/v1/targets(1934)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/publications"},"_namespace":null},{"id":1935,"version":3,"created":1554868882000,"modified":1555033683000,"deprecated":false,"name":"Myb-related transcription factor, partner of profilin","accession":"Q86VE0","gene":"MYPOP","description":"Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.17609125905568124,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.533333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":25.964559326189466,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(1935)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/properties"},"_links":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/publications"},"_namespace":null},{"id":1936,"version":2,"created":1554868884000,"modified":1554868887000,"deprecated":false,"name":"Post-GPI attachment to proteins factor 6","accession":"Q9HCN3","gene":"TMEM8A","description":"Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5682017245012895,"antibodyCount":16,"monoclonalCount":7,"pubmedCount":null,"jensenScore":3.554278,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.12404262197576,"pubTatorScore":0.985276713227949,"self":"https://pharos.nih.gov/idg/api/v1/targets(1936)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/publications"},"_namespace":null},{"id":1937,"version":3,"created":1554868888000,"modified":1555033685000,"deprecated":false,"name":"GC-rich sequence DNA-binding factor 2","accession":"P16383","gene":"GCFC2","description":"Factor that represses transcription. 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The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. 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Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6795088672480166,"antibodyCount":37,"monoclonalCount":7,"pubmedCount":null,"jensenScore":5.485787,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.288963231008765,"pubTatorScore":0.6234953209022511,"self":"https://pharos.nih.gov/idg/api/v1/targets(2148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(2148)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(2148)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(2148)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(2148)/publications"},"_namespace":null},{"id":2149,"version":2,"created":1554870035000,"modified":1554870037000,"deprecated":false,"name":"Paraneoplastic antigen-like protein 8A","accession":"Q86V59","gene":"PNMA8A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5563025007672873,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(2149)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(2149)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(2149)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(2149)/publications"},"_namespace":null},{"id":2150,"version":3,"created":1554870038000,"modified":1555033825000,"deprecated":false,"name":"Protection of telomeres protein 1","accession":"Q9NUX5","gene":"POT1","description":"Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. 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May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6029949037603524,"antibodyCount":77,"monoclonalCount":6,"pubmedCount":null,"jensenScore":37.930162,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.19328489918988,"pubTatorScore":1.1272591075390193,"self":"https://pharos.nih.gov/idg/api/v1/targets(2216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(2216)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(2216)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(2216)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(2216)/publications"},"_namespace":null},{"id":2217,"version":3,"created":1554870236000,"modified":1555033865000,"deprecated":false,"name":"Mitochondrial intermediate peptidase","accession":"Q99797","gene":"MIPEP","description":"Cleaves proteins, imported into the mitochondrion, to their mature size.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6313695353219788,"antibodyCount":277,"monoclonalCount":178,"pubmedCount":null,"jensenScore":42.55978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.85257531246033,"pubTatorScore":1.3057990209669108,"self":"https://pharos.nih.gov/idg/api/v1/targets(2217)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(2217)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(2217)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2217)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(2217)/publications"},"_namespace":null},{"id":2218,"version":2,"created":1554870239000,"modified":1554870242000,"deprecated":false,"name":"Ectopic P granules protein 5 homolog","accession":"Q9HCE0","gene":"EPG5","description":"Involved in autophagy. 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The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2537736689601693,"antibodyCount":105,"monoclonalCount":10,"pubmedCount":null,"jensenScore":19.021058,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.333616659120544,"pubTatorScore":1.342751554080407,"self":"https://pharos.nih.gov/idg/api/v1/targets(2301)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(2301)/properties"},"_links":{"count":1094,"href":"https://pharos.nih.gov/idg/api/v1/targets(2301)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(2301)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(2301)/publications"},"_namespace":null},{"id":2302,"version":4,"created":1554870504000,"modified":1555033917000,"deprecated":false,"name":"Equilibrative nucleoside transporter 1","accession":"Q99808","gene":"SLC29A1","description":"Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). 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Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. 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Plays a role in apoptosis negative control involved in brain development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.774155934827549,"antibodyCount":131,"monoclonalCount":46,"pubmedCount":null,"jensenScore":57.879913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.08992188346387,"pubTatorScore":0.9956351945975499,"self":"https://pharos.nih.gov/idg/api/v1/targets(2428)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/publications"},"_namespace":null},{"id":2429,"version":3,"created":1554870990000,"modified":1555034013000,"deprecated":false,"name":"Zinc transporter ZIP12","accession":"Q504Y0","gene":"SLC39A12","description":"Acts as a zinc-influx transporter (Potential). 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Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.9823250888944565,"antibodyCount":132,"monoclonalCount":52,"pubmedCount":null,"jensenScore":8.048146,"patentCount":724,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.319076560311764,"pubTatorScore":1.1417855397800447,"self":"https://pharos.nih.gov/idg/api/v1/targets(2433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/publications"},"_namespace":null},{"id":2434,"version":3,"created":1554871008000,"modified":1555034017000,"deprecated":false,"name":"Unconventional myosin-Va","accession":"Q9Y4I1","gene":"MYO5A","description":"Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. 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Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0487966765835433,"antibodyCount":151,"monoclonalCount":36,"pubmedCount":null,"jensenScore":11.573713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.08837429552159,"pubTatorScore":0.865630378263598,"self":"https://pharos.nih.gov/idg/api/v1/targets(2443)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/publications"},"_namespace":null},{"id":2444,"version":2,"created":1554871042000,"modified":1554871045000,"deprecated":false,"name":"RNA-binding protein 14","accession":"Q96PK6","gene":"RBM14","description":"Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. 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E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2500131487013686,"antibodyCount":38,"monoclonalCount":1,"pubmedCount":null,"jensenScore":18.440524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":46.99606687633982,"pubTatorScore":1.6928114166747799,"self":"https://pharos.nih.gov/idg/api/v1/targets(2492)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":522,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/properties"},"_links":{"count":1235,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/links"},"_synonyms":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/publications"},"_namespace":null},{"id":2493,"version":2,"created":1554871227000,"modified":1554871230000,"deprecated":false,"name":"LIM and SH3 domain protein 1","accession":"Q14847","gene":"LASP1","description":"Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. 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Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.467022799778345,"antibodyCount":245,"monoclonalCount":41,"pubmedCount":null,"jensenScore":275.1831,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.99153408830063,"pubTatorScore":2.203661975849583,"self":"https://pharos.nih.gov/idg/api/v1/targets(2495)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/publications"},"_namespace":null},{"id":2496,"version":3,"created":1554871249000,"modified":1555034063000,"deprecated":false,"name":"Phakinin","accession":"Q13515","gene":"BFSP2","description":"Involved in stabilization of lens fiber cell cytoskeleton.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5155691801039266,"antibodyCount":81,"monoclonalCount":37,"pubmedCount":null,"jensenScore":325.746497,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":24.284444600173497,"pubTatorScore":2.1573819886988583,"self":"https://pharos.nih.gov/idg/api/v1/targets(2496)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/properties"},"_links":{"count":501,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/publications"},"_namespace":null},{"id":2497,"version":2,"created":1554871251000,"modified":1554871254000,"deprecated":false,"name":"Protein BTG2","accession":"P78543","gene":"BTG2","description":"Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1037571583977814,"antibodyCount":209,"monoclonalCount":59,"pubmedCount":null,"jensenScore":142.735994,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.54098411069079,"pubTatorScore":2.1753232573209313,"self":"https://pharos.nih.gov/idg/api/v1/targets(2497)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/synonyms"},"_publications":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/publications"},"_namespace":null},{"id":2498,"version":3,"created":1554871254000,"modified":1555034067000,"deprecated":false,"name":"Lymphocyte antigen 86","accession":"O95711","gene":"LY86","description":"May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7184212649762483,"antibodyCount":272,"monoclonalCount":50,"pubmedCount":null,"jensenScore":481.625765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":61,"knowledgeAvailability":33.033621999557575,"pubTatorScore":0.9089338795053078,"self":"https://pharos.nih.gov/idg/api/v1/targets(2498)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/publications"},"_namespace":null},{"id":2499,"version":2,"created":1554871257000,"modified":1554871259000,"deprecated":false,"name":"Exocyst complex component 3-like protein","accession":"Q86VI1","gene":"EXOC3L1","description":"As part of the exocyst, may play a role in regulated exocytosis of insulin granules.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.10145763913017275,"antibodyCount":62,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.304386,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.391136320166208,"pubTatorScore":-0.10914490371976707,"self":"https://pharos.nih.gov/idg/api/v1/targets(2499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/publications"},"_namespace":null},{"id":2500,"version":3,"created":1554871260000,"modified":1555034068000,"deprecated":false,"name":"Prepronociceptin","accession":"Q13519","gene":"PNOC","description":"Orphanin FQ2: Has potent analgesic activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7808400220371294,"antibodyCount":207,"monoclonalCount":4,"pubmedCount":null,"jensenScore":685.704777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":25.104380394746673,"pubTatorScore":2.57556283949513,"self":"https://pharos.nih.gov/idg/api/v1/targets(2500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/properties"},"_links":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/synonyms"},"_publications":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/publications"},"_namespace":null},{"id":2501,"version":2,"created":1554871263000,"modified":1554871264000,"deprecated":false,"name":"Achaete-scute homolog 4","accession":"Q6XD76","gene":"ASCL4","description":"Could be a transcriptional regulator involved in skin development.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.3108281295445815,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.972757,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.80377682033055,"pubTatorScore":0.4419568899810447,"self":"https://pharos.nih.gov/idg/api/v1/targets(2501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/properties"},"_links":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/publications"},"_namespace":null},{"id":2502,"version":3,"created":1554871264000,"modified":1555034070000,"deprecated":false,"name":"StAR-related lipid transfer protein 3","accession":"Q14849","gene":"STARD3","description":"Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.617213982292178,"antibodyCount":37,"monoclonalCount":7,"pubmedCount":null,"jensenScore":39.37065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.53697748631886,"pubTatorScore":1.6500154469127115,"self":"https://pharos.nih.gov/idg/api/v1/targets(2502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/publications"},"_namespace":null},{"id":2503,"version":2,"created":1554871268000,"modified":1554871271000,"deprecated":false,"name":"Endonuclease III-like protein 1","accession":"P78549","gene":"NTHL1","description":"Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8506629354298685,"antibodyCount":155,"monoclonalCount":12,"pubmedCount":null,"jensenScore":66.754211,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.54842941786516,"pubTatorScore":1.7861833171452188,"self":"https://pharos.nih.gov/idg/api/v1/targets(2503)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/publications"},"_namespace":null},{"id":2504,"version":2,"created":1554871272000,"modified":1554871274000,"deprecated":false,"name":"Tubulin polyglutamylase TTLL5","accession":"Q6EMB2","gene":"TTLL5","description":"Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6704814706607193,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.780199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.46869337903896,"pubTatorScore":1.5043081652917765,"self":"https://pharos.nih.gov/idg/api/v1/targets(2504)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/publications"},"_namespace":null},{"id":2505,"version":2,"created":1554871275000,"modified":1554871277000,"deprecated":false,"name":"Carbohydrate sulfotransferase 2","accession":"Q9Y4C5","gene":"CHST2","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2944332996364818,"antibodyCount":188,"monoclonalCount":1,"pubmedCount":null,"jensenScore":20.943641,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.9424969737328,"pubTatorScore":1.2654096886225348,"self":"https://pharos.nih.gov/idg/api/v1/targets(2505)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/publications"},"_namespace":null},{"id":2506,"version":3,"created":1554871278000,"modified":1555034071000,"deprecated":false,"name":"Nucleolar protein 10","accession":"Q9BSC4","gene":"NOL10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.32585357963028805,"antibodyCount":59,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.369935,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":33.88292597402678,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(2506)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/publications"},"_namespace":null},{"id":2507,"version":2,"created":1554871280000,"modified":1554871282000,"deprecated":false,"name":"Malignant fibrous histiocytoma-amplified sequence 1","accession":"Q9Y4C4","gene":"MFHAS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7596332686251291,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.87136,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.30329064476425,"pubTatorScore":0.9439749912626114,"self":"https://pharos.nih.gov/idg/api/v1/targets(2507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/publications"},"_namespace":null},{"id":2508,"version":2,"created":1554871283000,"modified":1554871287000,"deprecated":false,"name":"Lysine-specific demethylase 3A","accession":"Q9Y4C1","gene":"KDM3A","description":"Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. 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Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.8354419439388556,"antibodyCount":253,"monoclonalCount":62,"pubmedCount":null,"jensenScore":74.687607,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.532143408688576,"pubTatorScore":1.6578531892034718,"self":"https://pharos.nih.gov/idg/api/v1/targets(2508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/publications"},"_namespace":null},{"id":2509,"version":3,"created":1554871288000,"modified":1555034073000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 35","accession":"A5YM69","gene":"ARHGEF35","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":9.64640156761473,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/publications"},"_namespace":null},{"id":2510,"version":3,"created":1554871290000,"modified":1555034074000,"deprecated":false,"name":"RWD domain-containing protein 2A","accession":"Q9UIY3","gene":"RWDD2A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0,"antibodyCount":43,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.712415380506815,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(2510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/publications"},"_namespace":null},{"id":2511,"version":2,"created":1554871293000,"modified":1554871296000,"deprecated":false,"name":"Neurexin-3","accession":"Q9Y4C0","gene":"NRXN3","description":"Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. 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Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. 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Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.80362205726688,"antibodyCount":376,"monoclonalCount":60,"pubmedCount":null,"jensenScore":549.597526,"patentCount":14037,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.36888076972349,"pubTatorScore":2.991556373265763,"self":"https://pharos.nih.gov/idg/api/v1/targets(2572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/properties"},"_links":{"count":1452,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/synonyms"},"_publications":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/publications"},"_namespace":null},{"id":2573,"version":2,"created":1554872366000,"modified":1554872368000,"deprecated":false,"name":"Endosomal/lysosomal potassium channel TMEM175","accession":"Q9BSA9","gene":"TMEM175","description":"Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. 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Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, SDCCAG3, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC complex subunits COMMD1, CCDC93 AND C16orf62 (PubMed:25355947). Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells (PubMed:18550675).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8363403373428943,"antibodyCount":45,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.5228787018508873,"self":"https://pharos.nih.gov/idg/api/v1/targets(2574)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/publications"},"_namespace":null},{"id":2575,"version":3,"created":1554872372000,"modified":1555034126000,"deprecated":false,"name":"Protein PML","accession":"P29590","gene":"PML","description":"Exhibits antiviral activity against both DNA and RNA viruses. 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Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6378531775694998,"antibodyCount":470,"monoclonalCount":99,"pubmedCount":null,"jensenScore":373.760337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":59.0043961457506,"pubTatorScore":3.102834436984397,"self":"https://pharos.nih.gov/idg/api/v1/targets(2575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/properties"},"_links":{"count":1698,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/synonyms"},"_publications":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/publications"},"_namespace":null},{"id":2576,"version":2,"created":1554872380000,"modified":1554872382000,"deprecated":false,"name":"Transmembrane protein 170A","accession":"Q8WVE7","gene":"TMEM170A","description":"Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. 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Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.107250385235662,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.544913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.59485324218395,"pubTatorScore":1.2265999052073575,"self":"https://pharos.nih.gov/idg/api/v1/targets(2595)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/publications"},"_namespace":null},{"id":2596,"version":2,"created":1554872456000,"modified":1554872459000,"deprecated":false,"name":"Protein phosphatase inhibitor 2","accession":"P41236","gene":"PPP1R2","description":"Inhibitor of protein-phosphatase 1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2052289524868685,"antibodyCount":259,"monoclonalCount":42,"pubmedCount":null,"jensenScore":26.245125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.80096174653072,"pubTatorScore":1.8056402449962383,"self":"https://pharos.nih.gov/idg/api/v1/targets(2596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/publications"},"_namespace":null},{"id":2597,"version":3,"created":1554872460000,"modified":1555034144000,"deprecated":false,"name":"Epidermal growth factor receptor substrate 15","accession":"P42566","gene":"EPS15","description":"Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2837378271827937,"antibodyCount":164,"monoclonalCount":7,"pubmedCount":null,"jensenScore":174.50817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.03869342642265,"pubTatorScore":2.0430947173808693,"self":"https://pharos.nih.gov/idg/api/v1/targets(2597)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/publications"},"_namespace":null},{"id":2598,"version":3,"created":1554872465000,"modified":1555034146000,"deprecated":false,"name":"Elongation factor Ts, mitochondrial","accession":"P43897","gene":"TSFM","description":"Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.307627275475032,"antibodyCount":123,"monoclonalCount":13,"pubmedCount":null,"jensenScore":199.39731,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":39.20422023574458,"pubTatorScore":1.6100846397757098,"self":"https://pharos.nih.gov/idg/api/v1/targets(2598)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/publications"},"_namespace":null},{"id":2599,"version":2,"created":1554872469000,"modified":1554872472000,"deprecated":false,"name":"C-C motif chemokine 20","accession":"P78556","gene":"CCL20","description":"Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1028349358622296,"antibodyCount":496,"monoclonalCount":242,"pubmedCount":null,"jensenScore":1250.330168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.023024280653996,"pubTatorScore":2.5749421541937734,"self":"https://pharos.nih.gov/idg/api/v1/targets(2599)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/synonyms"},"_publications":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/publications"},"_namespace":null},{"id":2600,"version":2,"created":1554872473000,"modified":1554872475000,"deprecated":false,"name":"RING finger protein 141","accession":"Q8WVD5","gene":"RNF141","description":"May be involved in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5298793068682367,"antibodyCount":159,"monoclonalCount":24,"pubmedCount":null,"jensenScore":3.397223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.91658066894902,"pubTatorScore":0.22902722033015813,"self":"https://pharos.nih.gov/idg/api/v1/targets(2600)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/publications"},"_namespace":null},{"id":2601,"version":2,"created":1554872476000,"modified":1554872478000,"deprecated":false,"name":"Copine-6","accession":"O95741","gene":"CPNE6","description":"Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7974026325913544,"antibodyCount":129,"monoclonalCount":30,"pubmedCount":null,"jensenScore":6.426953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.487965957138496,"pubTatorScore":0.5492076022531295,"self":"https://pharos.nih.gov/idg/api/v1/targets(2601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/publications"},"_namespace":null},{"id":2602,"version":2,"created":1554872479000,"modified":1554872481000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF138","accession":"Q8WVD3","gene":"RNF138","description":"E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0899624490445448,"antibodyCount":148,"monoclonalCount":6,"pubmedCount":null,"jensenScore":12.527552,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.03165499812923,"pubTatorScore":0.8774672947669043,"self":"https://pharos.nih.gov/idg/api/v1/targets(2602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/publications"},"_namespace":null},{"id":2603,"version":2,"created":1554872482000,"modified":1554872484000,"deprecated":false,"name":"Eukaryotic translation initiation factor 4E-binding protein 2","accession":"Q13542","gene":"EIF4EBP2","description":"Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5577644138317688,"antibodyCount":189,"monoclonalCount":12,"pubmedCount":null,"jensenScore":33.404476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.54326994927551,"pubTatorScore":1.3137375451344497,"self":"https://pharos.nih.gov/idg/api/v1/targets(2603)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/publications"},"_namespace":null},{"id":2604,"version":2,"created":1554872485000,"modified":1554872488000,"deprecated":false,"name":"Serine/threonine-protein kinase OSR1","accession":"O95747","gene":"OXSR1","description":"Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-0.9983612454189109,"antibodyCount":355,"monoclonalCount":165,"pubmedCount":null,"jensenScore":9.443281,"patentCount":3270,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.81185477344251,"pubTatorScore":0.8664983490238036,"self":"https://pharos.nih.gov/idg/api/v1/targets(2604)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/publications"},"_namespace":null},{"id":2605,"version":3,"created":1554872488000,"modified":1555034149000,"deprecated":false,"name":"Interleukin-13 receptor subunit alpha-1","accession":"P78552","gene":"IL13RA1","description":"Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4520501357913467,"antibodyCount":375,"monoclonalCount":101,"pubmedCount":null,"jensenScore":22.993724,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.68501576742811,"pubTatorScore":1.7444792907008082,"self":"https://pharos.nih.gov/idg/api/v1/targets(2605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/publications"},"_namespace":null},{"id":2606,"version":4,"created":1554872492000,"modified":1555034153000,"deprecated":false,"name":"Histone deacetylase 1","accession":"Q13547","gene":"HDAC1","description":"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-3.0377538187205158,"antibodyCount":1201,"monoclonalCount":217,"pubmedCount":null,"jensenScore":954.3175,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":76,"knowledgeAvailability":60.71544157786779,"pubTatorScore":2.8702212319894196,"self":"https://pharos.nih.gov/idg/api/v1/targets(2606)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/properties"},"_links":{"count":3828,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/synonyms"},"_publications":{"count":552,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/publications"},"_namespace":null},{"id":2607,"version":3,"created":1554873360000,"modified":1555034162000,"deprecated":false,"name":"Receptor-interacting serine/threonine-protein kinase 1","accession":"Q13546","gene":"RIPK1","description":"Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.339913726644165,"antibodyCount":375,"monoclonalCount":124,"pubmedCount":null,"jensenScore":211.835873,"patentCount":20387,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":47.93933928895063,"pubTatorScore":2.68297454645779,"self":"https://pharos.nih.gov/idg/api/v1/targets(2607)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/properties"},"_links":{"count":1248,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/synonyms"},"_publications":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/publications"},"_namespace":null},{"id":2608,"version":2,"created":1554873377000,"modified":1554873377000,"deprecated":false,"name":"Putative postmeiotic segregation increased 2-like protein 2","accession":"O95744","gene":"PMS2P2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.521999426090169,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2608)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/publications"},"_namespace":null},{"id":2609,"version":2,"created":1554873377000,"modified":1554873379000,"deprecated":false,"name":"FERM, ARHGEF and pleckstrin domain-containing protein 1","accession":"Q9Y4F1","gene":"FARP1","description":"Functions as guanine nucleotide exchange factor for RAC1. 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Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). 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Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. 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Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. 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Probably not involved in absorption of dietary fat in the small intestine (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0745992533913342,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.151445,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.094176674998835,"pubTatorScore":1.7214586693922311,"self":"https://pharos.nih.gov/idg/api/v1/targets(2669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/properties"},"_links":{"count":598,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/publications"},"_namespace":null},{"id":2670,"version":3,"created":1554873624000,"modified":1555034206000,"deprecated":false,"name":"Myosin-binding protein C, cardiac-type","accession":"Q14896","gene":"MYBPC3","description":"Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. 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Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. 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Also has ManNAc kinase activity.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.6389447079658863,"antibodyCount":210,"monoclonalCount":38,"pubmedCount":null,"jensenScore":41.939264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":38.026242265961976,"pubTatorScore":1.261262844995535,"self":"https://pharos.nih.gov/idg/api/v1/targets(2686)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/publications"},"_namespace":null},{"id":2687,"version":2,"created":1554873682000,"modified":1554873682000,"deprecated":false,"name":"Insulin, isoform 2","accession":"F8WCM5","gene":"INS-IGF2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9462146549001682,"antibodyCount":72,"monoclonalCount":58,"pubmedCount":null,"jensenScore":7.722942,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.40638361293695,"pubTatorScore":0.22184857589852885,"self":"https://pharos.nih.gov/idg/api/v1/targets(2687)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/properties"},"_links":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/publications"},"_namespace":null},{"id":2688,"version":3,"created":1554873682000,"modified":1555034222000,"deprecated":false,"name":"NudC domain-containing protein 2","accession":"Q8WVJ2","gene":"NUDCD2","description":"May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.3010299956639813,"antibodyCount":54,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.882462413401228,"pubTatorScore":-0.1389497358344748,"self":"https://pharos.nih.gov/idg/api/v1/targets(2688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/publications"},"_namespace":null},{"id":2689,"version":2,"created":1554873685000,"modified":1554873688000,"deprecated":false,"name":"Small membrane A-kinase anchor protein","accession":"Q9BSF0","gene":"C2orf88","description":"Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.35954361767421344,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.189394,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.45920968369704335,"self":"https://pharos.nih.gov/idg/api/v1/targets(2689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/publications"},"_namespace":null},{"id":2690,"version":2,"created":1554873688000,"modified":1554873691000,"deprecated":false,"name":"Unconventional myosin-X","accession":"Q9HD67","gene":"MYO10","description":"Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4985540180189592,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":36.44972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.48244883158517,"pubTatorScore":1.7267883970529034,"self":"https://pharos.nih.gov/idg/api/v1/targets(2690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/publications"},"_namespace":null},{"id":2691,"version":3,"created":1554873692000,"modified":1555034223000,"deprecated":false,"name":"Sigma intracellular receptor 2","accession":"Q5BJF2","gene":"TMEM97","description":"Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.2750095257655023,"antibodyCount":67,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.794309,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.25173780648409,"pubTatorScore":1.205925792529446,"self":"https://pharos.nih.gov/idg/api/v1/targets(2691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/publications"},"_namespace":null},{"id":2692,"version":3,"created":1554873697000,"modified":1555034224000,"deprecated":false,"name":"Breast cancer metastasis-suppressor 1","accession":"Q9HCU9","gene":"BRMS1","description":"Transcriptional repressor. 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May be a mediator of metastasis suppression in breast carcinoma.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6884737265046157,"antibodyCount":205,"monoclonalCount":40,"pubmedCount":null,"jensenScore":54.938129,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.560832473597145,"pubTatorScore":2.0325629516326655,"self":"https://pharos.nih.gov/idg/api/v1/targets(2692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/properties"},"_links":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/publications"},"_namespace":null},{"id":2693,"version":2,"created":1554873701000,"modified":1554873703000,"deprecated":false,"name":"DNA polymerase delta subunit 4","accession":"Q9HCU8","gene":"POLD4","description":"As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8488730486596557,"antibodyCount":24,"monoclonalCount":14,"pubmedCount":null,"jensenScore":7.321211,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.75395753941333,"pubTatorScore":1.1031110676340896,"self":"https://pharos.nih.gov/idg/api/v1/targets(2693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/publications"},"_namespace":null},{"id":2694,"version":2,"created":1554873704000,"modified":1554873705000,"deprecated":false,"name":"Annexin A10","accession":"Q9UJ72","gene":"ANXA10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3303983639857597,"antibodyCount":301,"monoclonalCount":54,"pubmedCount":null,"jensenScore":25.325146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.9264127108065,"pubTatorScore":1.4033458495313378,"self":"https://pharos.nih.gov/idg/api/v1/targets(2694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/properties"},"_links":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/publications"},"_namespace":null},{"id":2695,"version":2,"created":1554873705000,"modified":1554873707000,"deprecated":false,"name":"Mitochondrial import inner membrane translocase subunit Tim29","accession":"Q9BSF4","gene":"TIMM29","description":"Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. 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May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.3010299956639812,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/publications"},"_namespace":null},{"id":2696,"version":3,"created":1554873708000,"modified":1555034227000,"deprecated":false,"name":"Diacylglycerol kinase zeta","accession":"Q13574","gene":"DGKZ","description":"Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. 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Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.596876217336367,"antibodyCount":88,"monoclonalCount":6,"pubmedCount":null,"jensenScore":46.12173,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":45.877409277288905,"pubTatorScore":2.7909957069452913,"self":"https://pharos.nih.gov/idg/api/v1/targets(2699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":519,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/properties"},"_links":{"count":1170,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/publications"},"_namespace":null},{"id":2700,"version":3,"created":1554873721000,"modified":1555034234000,"deprecated":false,"name":"Inositol-tetrakisphosphate 1-kinase","accession":"Q13572","gene":"ITPK1","description":"Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.3843373297312092,"antibodyCount":201,"monoclonalCount":25,"pubmedCount":null,"jensenScore":24.778354,"patentCount":806,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.72310406626417,"pubTatorScore":1.2462757384430123,"self":"https://pharos.nih.gov/idg/api/v1/targets(2700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/publications"},"_namespace":null},{"id":2701,"version":3,"created":1554873724000,"modified":1555034237000,"deprecated":false,"name":"Outer dense fiber protein 2","accession":"Q5BJF6","gene":"ODF2","description":"Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. 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Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.8597308531956394,"antibodyCount":1160,"monoclonalCount":323,"pubmedCount":null,"jensenScore":723.440375,"patentCount":17380,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.30686744802299,"pubTatorScore":2.967767120295719,"self":"https://pharos.nih.gov/idg/api/v1/targets(2720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/properties"},"_links":{"count":1553,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/synonyms"},"_publications":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/publications"},"_namespace":null},{"id":2721,"version":2,"created":1554873836000,"modified":1554873836000,"deprecated":false,"name":"Putative uncharacterized protein FBXL19-AS1","accession":"Q494R0","gene":"FBXL19-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.741547609625183,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/publications"},"_namespace":null},{"id":2722,"version":3,"created":1554873837000,"modified":1555034252000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 8","accession":"P41279","gene":"MAP3K8","description":"Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.092296341326843,"antibodyCount":433,"monoclonalCount":21,"pubmedCount":null,"jensenScore":154.28257,"patentCount":54861,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.00266647402203,"pubTatorScore":2.012010857845673,"self":"https://pharos.nih.gov/idg/api/v1/targets(2722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":571,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/synonyms"},"_publications":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/publications"},"_namespace":null},{"id":2723,"version":2,"created":1554873857000,"modified":1554873859000,"deprecated":false,"name":"NADH-cytochrome b5 reductase 2","accession":"Q6BCY4","gene":"CYB5R2","description":"NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). 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Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6246016152220577,"antibodyCount":162,"monoclonalCount":10,"pubmedCount":null,"jensenScore":39.040329,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.410089364034754,"pubTatorScore":1.7233205435616321,"self":"https://pharos.nih.gov/idg/api/v1/targets(2726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/properties"},"_links":{"count":1117,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/publications"},"_namespace":null},{"id":2727,"version":2,"created":1554873869000,"modified":1554873871000,"deprecated":false,"name":"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein","accession":"Q9BSE4","gene":"HERPUD2","description":"Could be involved in the unfolded protein response (UPR) pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.195949938201696,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/publications"},"_namespace":null},{"id":2728,"version":2,"created":1554873871000,"modified":1554873873000,"deprecated":false,"name":"EF-hand calcium-binding domain-containing protein 10","accession":"A6NFE3","gene":"EFCAB10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.599378129394475,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/properties"},"_links":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/publications"},"_namespace":null},{"id":2729,"version":3,"created":1554873873000,"modified":1555034256000,"deprecated":false,"name":"Plexin-A1","accession":"Q9UIW2","gene":"PLXNA1","description":"Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.90927403612285,"antibodyCount":116,"monoclonalCount":28,"pubmedCount":null,"jensenScore":78.949715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.35977155294747,"pubTatorScore":1.4919024599298034,"self":"https://pharos.nih.gov/idg/api/v1/targets(2729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/publications"},"_namespace":null},{"id":2730,"version":3,"created":1554873877000,"modified":1555034258000,"deprecated":false,"name":"Ventral anterior homeobox 2","accession":"Q9UIW0","gene":"VAX2","description":"Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). 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The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. 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AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. 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Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.8029649220889077,"antibodyCount":204,"monoclonalCount":47,"pubmedCount":null,"jensenScore":657.033691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":35.04374980891447,"pubTatorScore":3.0552040479822944,"self":"https://pharos.nih.gov/idg/api/v1/targets(2758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/properties"},"_links":{"count":1137,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/publications"},"_namespace":null},{"id":2759,"version":2,"created":1554873995000,"modified":1554873998000,"deprecated":false,"name":"Zinc finger protein 682","accession":"O95780","gene":"ZNF682","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":132,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.93439505283389,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/publications"},"_namespace":null},{"id":2760,"version":3,"created":1554873998000,"modified":1555034285000,"deprecated":false,"name":"Helicase ARIP4","accession":"Q9Y4B4","gene":"RAD54L2","description":"DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. 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Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5934267803798767,"antibodyCount":285,"monoclonalCount":47,"pubmedCount":null,"jensenScore":43.704649,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":43.24995194564011,"pubTatorScore":1.6452261833806812,"self":"https://pharos.nih.gov/idg/api/v1/targets(2778)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/properties"},"_links":{"count":1239,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/publications"},"_namespace":null},{"id":2779,"version":3,"created":1554874053000,"modified":1555034302000,"deprecated":false,"name":"Transformer-2 protein homolog alpha","accession":"Q13595","gene":"TRA2A","description":"Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0559187915810377,"antibodyCount":139,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.337283,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":70,"knowledgeAvailability":37.40889090225303,"pubTatorScore":0.5585942232596517,"self":"https://pharos.nih.gov/idg/api/v1/targets(2779)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/publications"},"_namespace":null},{"id":2780,"version":2,"created":1554874056000,"modified":1554874059000,"deprecated":false,"name":"O-phosphoseryl-tRNA(Sec) selenium transferase","accession":"Q9HD40","gene":"SEPSECS","description":"Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1136237857407583,"antibodyCount":120,"monoclonalCount":6,"pubmedCount":null,"jensenScore":120.507818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.917274385382516,"pubTatorScore":1.9199327012181355,"self":"https://pharos.nih.gov/idg/api/v1/targets(2780)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/publications"},"_namespace":null},{"id":2781,"version":2,"created":1554874059000,"modified":1554874061000,"deprecated":false,"name":"Cadherin-22","accession":"Q9UJ99","gene":"CDH22","description":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8431649262756314,"antibodyCount":102,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.752219,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.57981923681721,"pubTatorScore":0.7286064110947115,"self":"https://pharos.nih.gov/idg/api/v1/targets(2781)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/properties"},"_links":{"count":735,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/publications"},"_namespace":null},{"id":2782,"version":2,"created":1554874062000,"modified":1554874064000,"deprecated":false,"name":"Receptor-type tyrosine-protein phosphatase H","accession":"Q9HD43","gene":"PTPRH","description":"Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8969939928865938,"antibodyCount":59,"monoclonalCount":1,"pubmedCount":null,"jensenScore":9.863132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.27058997525867,"pubTatorScore":1.1611539771081292,"self":"https://pharos.nih.gov/idg/api/v1/targets(2782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/publications"},"_namespace":null},{"id":2783,"version":3,"created":1554874065000,"modified":1555034303000,"deprecated":false,"name":"Transmembrane protein 41B","accession":"Q5BJD5","gene":"TMEM41B","description":"Required for normal motor neuron development.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":8,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.870725646592682,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2783)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/publications"},"_namespace":null},{"id":2784,"version":3,"created":1554874067000,"modified":1555034305000,"deprecated":false,"name":"Cytochrome P450 4F12","accession":"Q9HCS2","gene":"CYP4F12","description":"Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8879446482360372,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.482389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.35759890269329,"pubTatorScore":1.222015026510251,"self":"https://pharos.nih.gov/idg/api/v1/targets(2784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/publications"},"_namespace":null},{"id":2785,"version":2,"created":1554874070000,"modified":1554874073000,"deprecated":false,"name":"Charged multivesicular body protein 1a","accession":"Q9HD42","gene":"CHMP1A","description":"Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1557105620552068,"antibodyCount":161,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.919284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.15146936401897,"pubTatorScore":1.2294812579033902,"self":"https://pharos.nih.gov/idg/api/v1/targets(2785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/publications"},"_namespace":null},{"id":2786,"version":2,"created":1554874074000,"modified":1554874076000,"deprecated":false,"name":"Cohesin subunit SA-3","accession":"Q9UJ98","gene":"STAG3","description":"Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3005531416341467,"antibodyCount":104,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.018984,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.188160549211105,"pubTatorScore":0.9972835658976497,"self":"https://pharos.nih.gov/idg/api/v1/targets(2786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/publications"},"_namespace":null},{"id":2787,"version":2,"created":1554874077000,"modified":1554874079000,"deprecated":false,"name":"Cell surface hyaluronidase","accession":"Q9UHN6","gene":"TMEM2","description":"Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). 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Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0110600210387306,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.807419,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.484888720078544,"pubTatorScore":0.35057090479655373,"self":"https://pharos.nih.gov/idg/api/v1/targets(2787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/publications"},"_namespace":null},{"id":2788,"version":2,"created":1554874080000,"modified":1554874081000,"deprecated":false,"name":"Solute carrier family 25 member 53","accession":"Q5H9E4","gene":"SLC25A53","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":null,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.111138547596703,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/publications"},"_namespace":null},{"id":2789,"version":2,"created":1554874081000,"modified":1554874083000,"deprecated":false,"name":"Calsenilin","accession":"Q9Y2W7","gene":"KCNIP3","description":"May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.7230970021733263,"antibodyCount":369,"monoclonalCount":40,"pubmedCount":null,"jensenScore":55.992714,"patentCount":1800,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.92187980632766,"pubTatorScore":2.9930542957079744,"self":"https://pharos.nih.gov/idg/api/v1/targets(2789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/publications"},"_namespace":null},{"id":2790,"version":3,"created":1554874084000,"modified":1555034306000,"deprecated":false,"name":"Tudor and KH domain-containing protein","accession":"Q9Y2W6","gene":"TDRKH","description":"Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. 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May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.5097640823879783,"antibodyCount":38,"monoclonalCount":6,"pubmedCount":null,"jensenScore":3.514888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.263571566050516,"pubTatorScore":0.39694851260152836,"self":"https://pharos.nih.gov/idg/api/v1/targets(2790)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/publications"},"_namespace":null},{"id":2791,"version":2,"created":1554874088000,"modified":1554874088000,"deprecated":false,"name":"Uncharacterized protein C2orf74","accession":"A8MZ97","gene":"C2orf74","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.1282666794672542,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.325408,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.8964596713017872,"self":"https://pharos.nih.gov/idg/api/v1/targets(2791)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/properties"},"_links":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/publications"},"_namespace":null},{"id":2792,"version":3,"created":1554874088000,"modified":1555034308000,"deprecated":false,"name":"RNA-binding motif protein, X-linked 2","accession":"Q9Y388","gene":"RBMX2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.054792907340499,"antibodyCount":102,"monoclonalCount":1,"pubmedCount":null,"jensenScore":11.963031,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":26.26439508508208,"pubTatorScore":0.49279613655473026,"self":"https://pharos.nih.gov/idg/api/v1/targets(2792)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/publications"},"_namespace":null},{"id":2793,"version":2,"created":1554874091000,"modified":1554874093000,"deprecated":false,"name":"Endonuclease/exonuclease/phosphatase family domain-containing protein 1","accession":"Q7L9B9","gene":"EEPD1","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5584514183144745,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.447115,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.498658550752104,"pubTatorScore":0.057991892690873126,"self":"https://pharos.nih.gov/idg/api/v1/targets(2793)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/publications"},"_namespace":null},{"id":2794,"version":2,"created":1554874094000,"modified":1554874096000,"deprecated":false,"name":"Protein BEX1","accession":"Q9HBH7","gene":"BEX1","description":"Signaling adapter molecule involved in p75NTR/NGFR signaling. 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The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2675985998783523,"antibodyCount":162,"monoclonalCount":38,"pubmedCount":null,"jensenScore":21.199856,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.23119018034973,"pubTatorScore":1.1147776986284144,"self":"https://pharos.nih.gov/idg/api/v1/targets(3001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/publications"},"_namespace":null},{"id":3002,"version":2,"created":1554875598000,"modified":1554875600000,"deprecated":false,"name":"Calcium-regulated heat-stable protein 1","accession":"Q9Y2V2","gene":"CARHSP1","description":"Binds mRNA and regulates the stability of target mRNA. 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Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). 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Rho-2 GABA receptor could play a role in retinal neurotransmission.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.7436544253841788,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":53.859901,"patentCount":1150,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.74284246592097,"pubTatorScore":0.8465882745165487,"self":"https://pharos.nih.gov/idg/api/v1/targets(3010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/publications"},"_namespace":null},{"id":3011,"version":3,"created":1554875624000,"modified":1555034471000,"deprecated":false,"name":"Calcium-binding protein 39","accession":"Q9Y376","gene":"CAB39","description":"Component of a complex that binds and activates STK11/LKB1. 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Preferentially associates with the sarcoglycan subcomplex of the DGC.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6422208030778664,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":48.732585,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.98296812826166,"pubTatorScore":1.4912980440144215,"self":"https://pharos.nih.gov/idg/api/v1/targets(3013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/publications"},"_namespace":null},{"id":3014,"version":2,"created":1554875635000,"modified":1554875635000,"deprecated":false,"name":"Immunoglobulin lambda variable 5-39","accession":"A0A0G2JS06","gene":"IGLV5-39","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). 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The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9941188304798478,"antibodyCount":313,"monoclonalCount":72,"pubmedCount":null,"jensenScore":96.76713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":48.0881105701836,"pubTatorScore":1.7977566535369864,"self":"https://pharos.nih.gov/idg/api/v1/targets(3023)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/synonyms"},"_publications":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/publications"},"_namespace":null},{"id":3024,"version":2,"created":1554875683000,"modified":1554875685000,"deprecated":false,"name":"Dysbindin domain-containing protein 2","accession":"Q9BQY9","gene":"DBNDD2","description":"May modulate the activity of casein kinase-1. 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Required for the association of HIV-1 vpr with the host proteasome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.572819107856202,"antibodyCount":356,"monoclonalCount":68,"pubmedCount":null,"jensenScore":35.696191,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.48243414961172,"pubTatorScore":1.7446493574220558,"self":"https://pharos.nih.gov/idg/api/v1/targets(3025)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/properties"},"_links":{"count":1144,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/publications"},"_namespace":null},{"id":3026,"version":2,"created":1554875689000,"modified":1554875690000,"deprecated":false,"name":"WAP four-disulfide core domain protein 6","accession":"Q9BQY6","gene":"WFDC6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.03476210770686023,"antibodyCount":2,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.743589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.128914059590625,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3026)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/properties"},"_links":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/publications"},"_namespace":null},{"id":3027,"version":2,"created":1554875690000,"modified":1554875709000,"deprecated":false,"name":"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha","accession":"P16499","gene":"PDE6A","description":"This protein participates in processes of transmission and amplification of the visual signal.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.2922764854140782,"antibodyCount":111,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.270705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.043413971396944,"pubTatorScore":1.9701159226817389,"self":"https://pharos.nih.gov/idg/api/v1/targets(3027)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/publications"},"_namespace":null},{"id":3028,"version":2,"created":1554875710000,"modified":1554875712000,"deprecated":false,"name":"Phylloquinone omega-hydroxylase CYP4F11","accession":"Q9HBI6","gene":"CYP4F11","description":"Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. 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Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9631896808908474,"antibodyCount":81,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.784527,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.65492299041795,"pubTatorScore":0.8629922540626748,"self":"https://pharos.nih.gov/idg/api/v1/targets(3111)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/publications"},"_namespace":null},{"id":3112,"version":3,"created":1554876000000,"modified":1555034531000,"deprecated":false,"name":"Leucine-rich repeat and transmembrane domain-containing protein 2","accession":"Q8N967","gene":"LRTM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.33881855619146894,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.424242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":20.376803049321953,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3112)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/properties"},"_links":{"count":665,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/publications"},"_namespace":null},{"id":3113,"version":2,"created":1554876003000,"modified":1554876004000,"deprecated":false,"name":"Protein FAM83C","accession":"Q9BQN1","gene":"FAM83C","description":"May play a role in MAPK signaling.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.626682521751418,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(3113)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/properties"},"_links":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/publications"},"_namespace":null},{"id":3114,"version":2,"created":1554876005000,"modified":1554876007000,"deprecated":false,"name":"N6-adenosine-methyltransferase catalytic subunit","accession":"Q86U44","gene":"METTL3","description":"The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and haematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.761740065764843,"antibodyCount":94,"monoclonalCount":4,"pubmedCount":null,"jensenScore":60.489745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.83411852373786,"pubTatorScore":1.3724736412466039,"self":"https://pharos.nih.gov/idg/api/v1/targets(3114)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/properties"},"_links":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/publications"},"_namespace":null},{"id":3115,"version":3,"created":1554876008000,"modified":1555034534000,"deprecated":false,"name":"rRNA-processing protein FCF1 homolog","accession":"Q9Y324","gene":"FCF1","description":"Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.006221318956311,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":96.255789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":32.3200598024354,"pubTatorScore":1.177330298176396,"self":"https://pharos.nih.gov/idg/api/v1/targets(3115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/publications"},"_namespace":null},{"id":3116,"version":2,"created":1554876011000,"modified":1554876014000,"deprecated":false,"name":"Polyadenylate-binding protein 2","accession":"Q86U42","gene":"PABPN1","description":"Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters (PubMed:27871484).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4875731089631583,"antibodyCount":120,"monoclonalCount":13,"pubmedCount":null,"jensenScore":316.411224,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.61439117889239,"pubTatorScore":2.2081607884563956,"self":"https://pharos.nih.gov/idg/api/v1/targets(3116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/properties"},"_links":{"count":1202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/synonyms"},"_publications":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/publications"},"_namespace":null},{"id":3117,"version":2,"created":1554876015000,"modified":1554876017000,"deprecated":false,"name":"Zinc finger protein 257","accession":"Q9Y2Q1","gene":"ZNF257","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.130435,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.502930192622976,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(3117)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/publications"},"_namespace":null},{"id":3118,"version":3,"created":1554876018000,"modified":1555034536000,"deprecated":false,"name":"Thioredoxin-related transmembrane protein 2","accession":"Q9Y320","gene":"TMX2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9287493192879259,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.356068,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.77290262603219,"pubTatorScore":0.7556328786278821,"self":"https://pharos.nih.gov/idg/api/v1/targets(3118)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/publications"},"_namespace":null},{"id":3119,"version":2,"created":1554876020000,"modified":1554876024000,"deprecated":false,"name":"Phospholipid-transporting ATPase IA","accession":"Q9Y2Q0","gene":"ATP8A1","description":"Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal 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Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). May act as a ubiquitin E3 ligase. 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Required for the maintenance of inner ear hair cells.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2078290161886645,"antibodyCount":176,"monoclonalCount":70,"pubmedCount":null,"jensenScore":172.723269,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.16217723791701,"pubTatorScore":2.1956296890772684,"self":"https://pharos.nih.gov/idg/api/v1/targets(3228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/publications"},"_namespace":null},{"id":3229,"version":2,"created":1554876485000,"modified":1554876485000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC01546","accession":"A6NGU7","gene":"LINC01546","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.40539003260517,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/properties"},"_links":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/publications"},"_namespace":null},{"id":3230,"version":3,"created":1554876485000,"modified":1555034616000,"deprecated":false,"name":"2'-5'-oligoadenylate synthase 2","accession":"P29728","gene":"OAS2","description":"Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4149617003490071,"antibodyCount":293,"monoclonalCount":131,"pubmedCount":null,"jensenScore":20.840618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.234737278769295,"pubTatorScore":1.2566597640342612,"self":"https://pharos.nih.gov/idg/api/v1/targets(3230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/publications"},"_namespace":null},{"id":3231,"version":3,"created":1554876489000,"modified":1555034618000,"deprecated":false,"name":"Tetratricopeptide repeat protein 6","accession":"Q86TZ1","gene":"TTC6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2688453129607253,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.571429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":10.555409659497569,"pubTatorScore":-0.024823788098954087,"self":"https://pharos.nih.gov/idg/api/v1/targets(3231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/properties"},"_links":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/publications"},"_namespace":null},{"id":3232,"version":3,"created":1554876491000,"modified":1555034619000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DP beta 1 chain","accession":"P04440","gene":"HLA-DPB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6921938624792503,"antibodyCount":321,"monoclonalCount":148,"pubmedCount":null,"jensenScore":594.429944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":37.417493663890376,"pubTatorScore":2.1559791156840262,"self":"https://pharos.nih.gov/idg/api/v1/targets(3232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/properties"},"_links":{"count":1282,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/links"},"_synonyms":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/synonyms"},"_publications":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/publications"},"_namespace":null},{"id":3233,"version":3,"created":1554876497000,"modified":1554876584000,"deprecated":false,"name":"Protein kinase C beta type","accession":"P05771","gene":"PRKCB","description":"Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.0043722630484933,"antibodyCount":598,"monoclonalCount":71,"pubmedCount":null,"jensenScore":93.477696,"patentCount":10807,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":54.54878349827856,"pubTatorScore":2.5841151758603984,"self":"https://pharos.nih.gov/idg/api/v1/targets(3233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/properties"},"_links":{"count":1450,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/synonyms"},"_publications":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/publications"},"_namespace":null},{"id":3234,"version":2,"created":1554876586000,"modified":1554876588000,"deprecated":false,"name":"Hephaestin","accession":"Q9BQS7","gene":"HEPH","description":"May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.025354769576797,"antibodyCount":111,"monoclonalCount":36,"pubmedCount":null,"jensenScore":102.708136,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.59688151704589,"pubTatorScore":1.7030865578297858,"self":"https://pharos.nih.gov/idg/api/v1/targets(3234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/publications"},"_namespace":null},{"id":3235,"version":2,"created":1554876589000,"modified":1554876589000,"deprecated":false,"name":"Immunoglobulin heavy variable 5-10-1","accession":"A0A0J9YXX1","gene":"IGHV5-10-1","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/publications"},"_namespace":null},{"id":3236,"version":3,"created":1554876589000,"modified":1555034623000,"deprecated":false,"name":"Heat shock protein beta-9","accession":"Q9BQS6","gene":"HSPB9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8226166411218366,"antibodyCount":75,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.540554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":17.71891418198396,"pubTatorScore":0.5652574615955669,"self":"https://pharos.nih.gov/idg/api/v1/targets(3236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/properties"},"_links":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/publications"},"_namespace":null},{"id":3237,"version":2,"created":1554876590000,"modified":1554876590000,"deprecated":false,"name":"Putative uncharacterized protein C20orf78","accession":"Q9BR46","gene":"C20orf78","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/properties"},"_links":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/publications"},"_namespace":null},{"id":3238,"version":2,"created":1554876590000,"modified":1554876593000,"deprecated":false,"name":"Exosome complex exonuclease RRP44","accession":"Q9Y2L1","gene":"DIS3","description":"Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8072962586782289,"antibodyCount":141,"monoclonalCount":20,"pubmedCount":null,"jensenScore":64.210099,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.9129747937233,"pubTatorScore":1.4477475735399699,"self":"https://pharos.nih.gov/idg/api/v1/targets(3238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/publications"},"_namespace":null},{"id":3239,"version":3,"created":1554876594000,"modified":1555034623000,"deprecated":false,"name":"Glutathione S-transferase theta-1","accession":"P30711","gene":"GSTT1","description":"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. 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It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).","idgFamily":"Kinase","idgTDL":"Tdark","novelty":-0.04092795043405109,"antibodyCount":142,"monoclonalCount":21,"pubmedCount":null,"jensenScore":1.085714,"patentCount":1673,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.346294517281013,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3276)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/publications"},"_namespace":null},{"id":3277,"version":3,"created":1554876739000,"modified":1555034649000,"deprecated":false,"name":"Cell death activator CIDE-B","accession":"Q9UHD4","gene":"CIDEB","description":"Activates apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.292161665997601,"antibodyCount":249,"monoclonalCount":27,"pubmedCount":null,"jensenScore":23.591574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.41911227198315,"pubTatorScore":1.2581698894143782,"self":"https://pharos.nih.gov/idg/api/v1/targets(3277)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/publications"},"_namespace":null},{"id":3278,"version":2,"created":1554876742000,"modified":1554876765000,"deprecated":false,"name":"Scavenger receptor class B member 1","accession":"Q8WTV0","gene":"SCARB1","description":"(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.939203982426617,"antibodyCount":378,"monoclonalCount":81,"pubmedCount":null,"jensenScore":915.723341,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.673156794159,"pubTatorScore":2.727438818953321,"self":"https://pharos.nih.gov/idg/api/v1/targets(3278)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":696,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/properties"},"_links":{"count":1299,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/synonyms"},"_publications":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/publications"},"_namespace":null},{"id":3279,"version":3,"created":1554876767000,"modified":1555034652000,"deprecated":false,"name":"THAP domain-containing protein 3","accession":"Q8WTV1","gene":"THAP3","description":"Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.5440680443502757,"antibodyCount":28,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.233108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":29.195064730783304,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/publications"},"_namespace":null},{"id":3280,"version":3,"created":1554876770000,"modified":1555034653000,"deprecated":false,"name":"Serine/threonine-protein kinase TBK1","accession":"Q9UHD2","gene":"TBK1","description":"Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.7672782675143526,"antibodyCount":455,"monoclonalCount":105,"pubmedCount":null,"jensenScore":569.148945,"patentCount":19375,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.73110335667031,"pubTatorScore":2.53150513486421,"self":"https://pharos.nih.gov/idg/api/v1/targets(3280)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/properties"},"_links":{"count":1306,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/synonyms"},"_publications":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/publications"},"_namespace":null},{"id":3281,"version":3,"created":1554876806000,"modified":1555034655000,"deprecated":false,"name":"Cysteine and histidine-rich domain-containing protein 1","accession":"Q9UHD1","gene":"CHORDC1","description":"Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5378190987647773,"antibodyCount":157,"monoclonalCount":4,"pubmedCount":null,"jensenScore":2.152274,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.38127909753965,"pubTatorScore":0.693873388727159,"self":"https://pharos.nih.gov/idg/api/v1/targets(3281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/publications"},"_namespace":null},{"id":3282,"version":3,"created":1554876809000,"modified":1555034657000,"deprecated":false,"name":"Kelch-like protein 20","accession":"Q9Y2M5","gene":"KLHL20","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7042458748373711,"antibodyCount":76,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.773843,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":36.26817780826337,"pubTatorScore":0.8494584186925345,"self":"https://pharos.nih.gov/idg/api/v1/targets(3282)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/publications"},"_namespace":null},{"id":3283,"version":2,"created":1554876813000,"modified":1554876816000,"deprecated":false,"name":"Septin-9","accession":"Q9UHD8","gene":"SEPT9","description":"Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2089763892385057,"antibodyCount":130,"monoclonalCount":4,"pubmedCount":null,"jensenScore":161.903261,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.708296308402524,"pubTatorScore":2.1319263527215027,"self":"https://pharos.nih.gov/idg/api/v1/targets(3283)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":498,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/properties"},"_links":{"count":1430,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/links"},"_synonyms":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/publications"},"_namespace":null},{"id":3284,"version":2,"created":1554876818000,"modified":1554876820000,"deprecated":false,"name":"Midasin","accession":"Q9NU22","gene":"MDN1","description":"Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.2317547170344818,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.266918,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.842612720853225,"pubTatorScore":1.0600679589174657,"self":"https://pharos.nih.gov/idg/api/v1/targets(3284)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/publications"},"_namespace":null},{"id":3285,"version":3,"created":1554876821000,"modified":1555034658000,"deprecated":false,"name":"LYR motif-containing protein 2","accession":"Q9NU23","gene":"LYRM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":95,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.309528651376876,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3285)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/properties"},"_links":{"count":734,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/publications"},"_namespace":null},{"id":3286,"version":2,"created":1554876823000,"modified":1554876825000,"deprecated":false,"name":"Phospholipase ABHD3","accession":"Q8WU67","gene":"ABHD3","description":"Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4121804524915048,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.225491,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.366070812284867,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3286)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/publications"},"_namespace":null},{"id":3287,"version":2,"created":1554876826000,"modified":1554876828000,"deprecated":false,"name":"Splicing factor U2AF 26 kDa subunit","accession":"Q8WU68","gene":"U2AF1L4","description":"RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.17609125688420882,"antibodyCount":61,"monoclonalCount":8,"pubmedCount":null,"jensenScore":1.858334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.975073729738632,"pubTatorScore":0.728450290201975,"self":"https://pharos.nih.gov/idg/api/v1/targets(3287)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/publications"},"_namespace":null},{"id":3288,"version":3,"created":1554876829000,"modified":1555034660000,"deprecated":false,"name":"Interleukin-12 receptor subunit beta-2","accession":"Q99665","gene":"IL12RB2","description":"Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. 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Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.6255266109360247,"antibodyCount":500,"monoclonalCount":151,"pubmedCount":null,"jensenScore":373.209902,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.210115840422205,"pubTatorScore":2.5120442165790884,"self":"https://pharos.nih.gov/idg/api/v1/targets(3352)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":566,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/properties"},"_links":{"count":1221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/synonyms"},"_publications":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/publications"},"_namespace":null},{"id":3353,"version":3,"created":1554877104000,"modified":1555034720000,"deprecated":false,"name":"V-type proton ATPase 116 kDa subunit a isoform 3","accession":"Q13488","gene":"TCIRG1","description":"Part of the proton channel of V-ATPases (By similarity). 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Recruits TBP and BRF2 to the U6 snRNA TATA box.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5482378119823216,"antibodyCount":130,"monoclonalCount":9,"pubmedCount":null,"jensenScore":3.004938,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.533662199843686,"pubTatorScore":0.7871367230121106,"self":"https://pharos.nih.gov/idg/api/v1/targets(3354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/publications"},"_namespace":null},{"id":3355,"version":3,"created":1554877112000,"modified":1555034722000,"deprecated":false,"name":"Cytohesin-4","accession":"Q9UIA0","gene":"CYTH4","description":"Promotes guanine-nucleotide exchange on ARF1 and ARF5. 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Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors (By similarity). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0842124807154345,"antibodyCount":236,"monoclonalCount":208,"pubmedCount":null,"jensenScore":120.472081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.13871029594798,"pubTatorScore":1.8650182033803437,"self":"https://pharos.nih.gov/idg/api/v1/targets(3357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/properties"},"_links":{"count":1223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/publications"},"_namespace":null},{"id":3358,"version":2,"created":1554877123000,"modified":1554877123000,"deprecated":false,"name":"Uncharacterized protein C9orf163","accession":"Q8N9P6","gene":"C9orf163","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/properties"},"_links":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/publications"},"_namespace":null},{"id":3359,"version":2,"created":1554877123000,"modified":1554877125000,"deprecated":false,"name":"Reticulon-4 receptor-like 2","accession":"Q86UN3","gene":"RTN4RL2","description":"Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1191595508645773,"antibodyCount":90,"monoclonalCount":20,"pubmedCount":null,"jensenScore":14.451902,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.826100848078237,"pubTatorScore":0.9736408034699406,"self":"https://pharos.nih.gov/idg/api/v1/targets(3359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/publications"},"_namespace":null},{"id":3360,"version":2,"created":1554877126000,"modified":1554877128000,"deprecated":false,"name":"Reticulon-4 receptor-like 1","accession":"Q86UN2","gene":"RTN4RL1","description":"Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8133373785276958,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.427447,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.095940149222493,"pubTatorScore":0.7856121770181471,"self":"https://pharos.nih.gov/idg/api/v1/targets(3360)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/publications"},"_namespace":null},{"id":3361,"version":2,"created":1554877129000,"modified":1554877131000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 2B","accession":"A6NFX1","gene":"MFSD2B","description":"Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4051185965563696,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.187179,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.681552101364087,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/properties"},"_links":{"count":709,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/publications"},"_namespace":null},{"id":3362,"version":2,"created":1554877132000,"modified":1554877134000,"deprecated":false,"name":"Zinc finger protein 251","accession":"Q9BRH9","gene":"ZNF251","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.3672350361350055,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.326705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.394590912001675,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/publications"},"_namespace":null},{"id":3363,"version":3,"created":1554877134000,"modified":1555034724000,"deprecated":false,"name":"Probable lysosomal cobalamin transporter","accession":"Q9NUN5","gene":"LMBRD1","description":"Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1051751581185276,"antibodyCount":54,"monoclonalCount":2,"pubmedCount":null,"jensenScore":126.109666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.97476067727002,"pubTatorScore":1.227653022161968,"self":"https://pharos.nih.gov/idg/api/v1/targets(3363)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/publications"},"_namespace":null},{"id":3364,"version":2,"created":1554877138000,"modified":1554877141000,"deprecated":false,"name":"Exportin-7","accession":"Q9UIA9","gene":"XPO7","description":"Mediates the nuclear export of proteins (cargos) with broad substrate specificity. 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The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0189348382146024,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.194851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.653219252173244,"pubTatorScore":0.8050475689421027,"self":"https://pharos.nih.gov/idg/api/v1/targets(3364)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/publications"},"_namespace":null},{"id":3365,"version":2,"created":1554877141000,"modified":1554877144000,"deprecated":false,"name":"Alkaline ceramidase 3","accession":"Q9NUN7","gene":"ACER3","description":"Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. 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Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. 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Required for skeletal muscle maintenance but not for myogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.725071269577345,"antibodyCount":235,"monoclonalCount":10,"pubmedCount":null,"jensenScore":527.34422,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":39.00619433703778,"pubTatorScore":2.1854319666280095,"self":"https://pharos.nih.gov/idg/api/v1/targets(3370)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/publications"},"_namespace":null},{"id":3371,"version":2,"created":1554877258000,"modified":1554877261000,"deprecated":false,"name":"Mastermind-like domain-containing protein 1","accession":"Q13495","gene":"MAMLD1","description":"Transactivates the HES3 promoter independently of NOTCH proteins. 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Involved in the suppression of glioma (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2985802011233805,"antibodyCount":70,"monoclonalCount":9,"pubmedCount":null,"jensenScore":23.513502,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":23.646426859222046,"pubTatorScore":1.3687670216297476,"self":"https://pharos.nih.gov/idg/api/v1/targets(3373)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/publications"},"_namespace":null},{"id":3374,"version":2,"created":1554877271000,"modified":1554877275000,"deprecated":false,"name":"Mucin-5B","accession":"Q9HC84","gene":"MUC5B","description":"Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.2032245226424427,"antibodyCount":177,"monoclonalCount":70,"pubmedCount":null,"jensenScore":1552.242981,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.222877305555215,"pubTatorScore":2.6946176739730583,"self":"https://pharos.nih.gov/idg/api/v1/targets(3374)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/publications"},"_namespace":null},{"id":3375,"version":3,"created":1554877277000,"modified":1555034735000,"deprecated":false,"name":"Succinate dehydrogenase assembly factor 1, mitochondrial","accession":"A6NFY7","gene":"SDHAF1","description":"Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. 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Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.9839361351506242,"antibodyCount":265,"monoclonalCount":4,"pubmedCount":null,"jensenScore":89.313873,"patentCount":14243,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.09224011138864,"pubTatorScore":1.9348154916639104,"self":"https://pharos.nih.gov/idg/api/v1/targets(3376)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/publications"},"_namespace":null},{"id":3377,"version":3,"created":1554877295000,"modified":1555034738000,"deprecated":false,"name":"Membrane-anchored junction protein","accession":"Q3KP22","gene":"MAJIN","description":"Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. 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MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.24303804977203064,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.794259,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3377)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/properties"},"_links":{"count":626,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/publications"},"_namespace":null},{"id":3378,"version":2,"created":1554877297000,"modified":1554877299000,"deprecated":false,"name":"SLAM family member 5","accession":"Q9UIB8","gene":"CD84","description":"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. 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In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). 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Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3624316242764876,"antibodyCount":109,"monoclonalCount":7,"pubmedCount":null,"jensenScore":22.958218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.42953485021968,"pubTatorScore":1.097451362292515,"self":"https://pharos.nih.gov/idg/api/v1/targets(3385)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/publications"},"_namespace":null},{"id":3386,"version":2,"created":1554877329000,"modified":1554877332000,"deprecated":false,"name":"Centromere protein J","accession":"Q9HC77","gene":"CENPJ","description":"Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). 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Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.1995723530956438,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.833333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3513)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/publications"},"_namespace":null},{"id":3514,"version":3,"created":1554879392000,"modified":1555034824000,"deprecated":false,"name":"Ubiquitin domain-containing protein 2","accession":"Q8WUN7","gene":"UBTD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6577461741086896,"antibodyCount":116,"monoclonalCount":32,"pubmedCount":null,"jensenScore":5.036663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":24.192754741755248,"pubTatorScore":0.7436404253784553,"self":"https://pharos.nih.gov/idg/api/v1/targets(3514)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/publications"},"_namespace":null},{"id":3515,"version":3,"created":1554879394000,"modified":1555034825000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX28","accession":"Q9NUL7","gene":"DDX28","description":"Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6180480884604976,"antibodyCount":109,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.540909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":32.33689096251899,"pubTatorScore":0.6483600109809317,"self":"https://pharos.nih.gov/idg/api/v1/targets(3515)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/publications"},"_namespace":null},{"id":3516,"version":2,"created":1554879397000,"modified":1554879398000,"deprecated":false,"name":"39S ribosomal protein L45, mitochondrial","accession":"Q9BRJ2","gene":"MRPL45","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5093059379876602,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.233334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.603086016213666,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3516)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/properties"},"_links":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/publications"},"_namespace":null},{"id":3517,"version":2,"created":1554879398000,"modified":1554879401000,"deprecated":false,"name":"Quinone oxidoreductase-like protein 1","accession":"O95825","gene":"CRYZL1","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3795069704868077,"antibodyCount":157,"monoclonalCount":43,"pubmedCount":null,"jensenScore":20.513476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.41619385074886,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/publications"},"_namespace":null},{"id":3518,"version":3,"created":1554879402000,"modified":1555034826000,"deprecated":false,"name":"Serine/threonine-protein kinase Sgk2","accession":"Q9HBY8","gene":"SGK2","description":"Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.806718193228615,"antibodyCount":223,"monoclonalCount":71,"pubmedCount":null,"jensenScore":4.282946,"patentCount":4248,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.09585466253001,"pubTatorScore":0.8916576943257375,"self":"https://pharos.nih.gov/idg/api/v1/targets(3518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/publications"},"_namespace":null},{"id":3519,"version":2,"created":1554879407000,"modified":1554879410000,"deprecated":false,"name":"Mesoderm posterior protein 1","accession":"Q9BRJ9","gene":"MESP1","description":"Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3853552119220134,"antibodyCount":208,"monoclonalCount":78,"pubmedCount":null,"jensenScore":26.770514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.693983707041177,"pubTatorScore":1.4024085876333938,"self":"https://pharos.nih.gov/idg/api/v1/targets(3519)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/properties"},"_links":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/publications"},"_namespace":null},{"id":3520,"version":3,"created":1554879411000,"modified":1555034828000,"deprecated":false,"name":"Tudor-interacting repair regulator protein","accession":"Q9BRJ7","gene":"NUDT16L1","description":"Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.544068022635552,"antibodyCount":44,"monoclonalCount":5,"pubmedCount":null,"jensenScore":33.522222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.671377373198197,"pubTatorScore":0.8750612633917001,"self":"https://pharos.nih.gov/idg/api/v1/targets(3520)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/publications"},"_namespace":null},{"id":3521,"version":2,"created":1554879413000,"modified":1554879416000,"deprecated":false,"name":"Uncharacterized protein C7orf50","accession":"Q9BRJ6","gene":"C7orf50","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":87,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3521)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/properties"},"_links":{"count":1068,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/publications"},"_namespace":null},{"id":3522,"version":2,"created":1554879416000,"modified":1554879419000,"deprecated":false,"name":"Arfaptin-1","accession":"P53367","gene":"ARFIP1","description":"Putative target protein of ADP-ribosylation factor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4425793046961826,"antibodyCount":199,"monoclonalCount":9,"pubmedCount":null,"jensenScore":4.762154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.58310895663183,"pubTatorScore":0.46311055451601085,"self":"https://pharos.nih.gov/idg/api/v1/targets(3522)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/publications"},"_namespace":null},{"id":3523,"version":3,"created":1554879420000,"modified":1555034829000,"deprecated":false,"name":"Voltage-gated potassium channel subunit beta-1","accession":"Q14722","gene":"KCNAB1","description":"Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.734411045181535,"antibodyCount":218,"monoclonalCount":110,"pubmedCount":null,"jensenScore":56.324767,"patentCount":1214,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.080588141065846,"pubTatorScore":1.5230690895767955,"self":"https://pharos.nih.gov/idg/api/v1/targets(3523)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/publications"},"_namespace":null},{"id":3524,"version":3,"created":1554879423000,"modified":1555034830000,"deprecated":false,"name":"Apoptosis-inducing factor 1, mitochondrial","accession":"O95831","gene":"AIFM1","description":"Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7407220430914006,"antibodyCount":637,"monoclonalCount":73,"pubmedCount":null,"jensenScore":50.522812,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":49.17161229799191,"pubTatorScore":2.0515900283762103,"self":"https://pharos.nih.gov/idg/api/v1/targets(3524)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/properties"},"_links":{"count":1284,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/synonyms"},"_publications":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/publications"},"_namespace":null},{"id":3525,"version":2,"created":1554879432000,"modified":1554879432000,"deprecated":false,"name":"Zinc finger CCHC domain-containing protein 3","accession":"Q9NUD5","gene":"ZCCHC3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":38,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.416584638987157,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3525)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/properties"},"_links":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/publications"},"_namespace":null},{"id":3526,"version":2,"created":1554879432000,"modified":1554879440000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily B member 1","accession":"Q14721","gene":"KCNB1","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.574839263760118,"antibodyCount":303,"monoclonalCount":77,"pubmedCount":null,"jensenScore":386.036388,"patentCount":4428,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.733890383717345,"pubTatorScore":2.331585939915935,"self":"https://pharos.nih.gov/idg/api/v1/targets(3526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/publications"},"_namespace":null},{"id":3527,"version":3,"created":1554879441000,"modified":1555034832000,"deprecated":false,"name":"Uncharacterized protein C20orf96","accession":"Q9NUD7","gene":"C20orf96","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/properties"},"_links":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/publications"},"_namespace":null},{"id":3528,"version":3,"created":1554879444000,"modified":1555034833000,"deprecated":false,"name":"Arfaptin-2","accession":"P53365","gene":"ARFIP2","description":"Putative target protein of ADP-ribosylation factor. 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With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.283648525166554,"antibodyCount":194,"monoclonalCount":71,"pubmedCount":null,"jensenScore":191.088077,"patentCount":50553,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.12396530275271,"pubTatorScore":2.4687332437404277,"self":"https://pharos.nih.gov/idg/api/v1/targets(3629)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/publications"},"_namespace":null},{"id":3630,"version":3,"created":1554879850000,"modified":1555034896000,"deprecated":false,"name":"Enolase-phosphatase E1","accession":"Q9UHY7","gene":"ENOPH1","description":"Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9836334384934999,"antibodyCount":124,"monoclonalCount":38,"pubmedCount":null,"jensenScore":9.95626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":36.62768161725971,"pubTatorScore":1.1279142943715932,"self":"https://pharos.nih.gov/idg/api/v1/targets(3630)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/publications"},"_namespace":null},{"id":3631,"version":2,"created":1554879853000,"modified":1554879856000,"deprecated":false,"name":"Tetraspanin-12","accession":"O95859","gene":"TSPAN12","description":"Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.331299473586608,"antibodyCount":141,"monoclonalCount":16,"pubmedCount":null,"jensenScore":21.474008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.04780342228656,"pubTatorScore":1.874002327406041,"self":"https://pharos.nih.gov/idg/api/v1/targets(3631)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/publications"},"_namespace":null},{"id":3632,"version":2,"created":1554879857000,"modified":1554879859000,"deprecated":false,"name":"Tetraspanin-15","accession":"O95858","gene":"TSPAN15","description":"Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.296533821285532,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.33737,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.367044336836965,"pubTatorScore":0.3706276157340919,"self":"https://pharos.nih.gov/idg/api/v1/targets(3632)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/publications"},"_namespace":null},{"id":3633,"version":2,"created":1554879860000,"modified":1554879862000,"deprecated":false,"name":"Cerebral cavernous malformations 2 protein-like","accession":"Q9NUG4","gene":"CCM2L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.242262,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.91791595440127,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3633)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/properties"},"_links":{"count":723,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/publications"},"_namespace":null},{"id":3634,"version":2,"created":1554879862000,"modified":1554879871000,"deprecated":false,"name":"Abelson tyrosine-protein kinase 2","accession":"P42684","gene":"ABL2","description":"Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.8629327696584348,"antibodyCount":358,"monoclonalCount":107,"pubmedCount":null,"jensenScore":71.204995,"patentCount":8984519,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.45675342150125,"pubTatorScore":1.6525378104983264,"self":"https://pharos.nih.gov/idg/api/v1/targets(3634)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/publications"},"_namespace":null},{"id":3635,"version":2,"created":1554879872000,"modified":1554879877000,"deprecated":false,"name":"Tyrosine-protein kinase FRK","accession":"P42685","gene":"FRK","description":"Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.6836546867359994,"antibodyCount":394,"monoclonalCount":117,"pubmedCount":null,"jensenScore":49.1682,"patentCount":17534,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.26682722547527,"pubTatorScore":1.8588596467542158,"self":"https://pharos.nih.gov/idg/api/v1/targets(3635)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/publications"},"_namespace":null},{"id":3636,"version":3,"created":1554879878000,"modified":1555034897000,"deprecated":false,"name":"Transcription elongation factor A protein-like 5","accession":"Q5H9L2","gene":"TCEAL5","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":18,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.428571,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":17.300123255965254,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3636)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/publications"},"_namespace":null},{"id":3637,"version":3,"created":1554879880000,"modified":1555034898000,"deprecated":false,"name":"Serine/threonine-protein kinase tousled-like 2","accession":"Q86UE8","gene":"TLK2","description":"Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.9545555531236226,"antibodyCount":210,"monoclonalCount":57,"pubmedCount":null,"jensenScore":10.069359,"patentCount":1607,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.544209895708114,"pubTatorScore":0.9507549598983293,"self":"https://pharos.nih.gov/idg/api/v1/targets(3637)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/publications"},"_namespace":null},{"id":3638,"version":2,"created":1554879883000,"modified":1554879886000,"deprecated":false,"name":"p53 and DNA damage-regulated protein 1","accession":"Q9NUG6","gene":"PDRG1","description":"May play a role in chaperone-mediated protein folding.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0084987662856586,"antibodyCount":96,"monoclonalCount":9,"pubmedCount":null,"jensenScore":9.955465,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.180798987588823,"pubTatorScore":0.7683914377703095,"self":"https://pharos.nih.gov/idg/api/v1/targets(3638)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/publications"},"_namespace":null},{"id":3639,"version":2,"created":1554879887000,"modified":1554879890000,"deprecated":false,"name":"Alpha-1-syntrophin","accession":"Q13424","gene":"SNTA1","description":"Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4922694443867182,"antibodyCount":254,"monoclonalCount":109,"pubmedCount":null,"jensenScore":31.435838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.76502745922662,"pubTatorScore":1.1569363003466,"self":"https://pharos.nih.gov/idg/api/v1/targets(3639)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/publications"},"_namespace":null},{"id":3640,"version":2,"created":1554879891000,"modified":1554879894000,"deprecated":false,"name":"Fatty acid desaturase 2","accession":"O95864","gene":"FADS2","description":"Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.5541110302858776,"antibodyCount":135,"monoclonalCount":2,"pubmedCount":null,"jensenScore":349.594681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.68490703078108,"pubTatorScore":2.484993288010833,"self":"https://pharos.nih.gov/idg/api/v1/targets(3640)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/properties"},"_links":{"count":1144,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/synonyms"},"_publications":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/publications"},"_namespace":null},{"id":3641,"version":2,"created":1554879895000,"modified":1554879898000,"deprecated":false,"name":"NAD(P) transhydrogenase, mitochondrial","accession":"Q13423","gene":"NNT","description":"The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.496240630839991,"antibodyCount":112,"monoclonalCount":17,"pubmedCount":null,"jensenScore":309.231092,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.9236501877318,"pubTatorScore":1.295635548174394,"self":"https://pharos.nih.gov/idg/api/v1/targets(3641)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/publications"},"_namespace":null},{"id":3642,"version":3,"created":1554879899000,"modified":1555034900000,"deprecated":false,"name":"Zinc finger protein SNAI1","accession":"O95863","gene":"SNAI1","description":"Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. 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In addition, may also activate the CDKN2B promoter by itself.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.286358278179855,"antibodyCount":566,"monoclonalCount":135,"pubmedCount":null,"jensenScore":1782.85577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":42.9388809278787,"pubTatorScore":3.2595040270110984,"self":"https://pharos.nih.gov/idg/api/v1/targets(3642)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/properties"},"_links":{"count":1367,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/synonyms"},"_publications":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/publications"},"_namespace":null},{"id":3643,"version":3,"created":1554879907000,"modified":1555034903000,"deprecated":false,"name":"DNA-binding protein Ikaros","accession":"Q13422","gene":"IKZF1","description":"Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). 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Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.6673171919419114,"antibodyCount":400,"monoclonalCount":75,"pubmedCount":null,"jensenScore":483.578609,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":44.00603104328681,"pubTatorScore":2.6414700610362156,"self":"https://pharos.nih.gov/idg/api/v1/targets(3643)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":557,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/properties"},"_links":{"count":1260,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/synonyms"},"_publications":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/publications"},"_namespace":null},{"id":3644,"version":3,"created":1554879913000,"modified":1555034906000,"deprecated":false,"name":"3'(2'),5'-bisphosphate nucleotidase 1","accession":"O95861","gene":"BPNT1","description":"Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. 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Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. 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Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.6462222116953784,"antibodyCount":461,"monoclonalCount":153,"pubmedCount":null,"jensenScore":378.194273,"patentCount":15449,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.70939010319713,"pubTatorScore":2.470502005146432,"self":"https://pharos.nih.gov/idg/api/v1/targets(3776)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/properties"},"_links":{"count":1593,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/links"},"_synonyms":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/synonyms"},"_publications":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/publications"},"_namespace":null},{"id":3777,"version":2,"created":1554880499000,"modified":1554880501000,"deprecated":false,"name":"Putative sodium-coupled neutral amino acid transporter 10","accession":"Q9HBR0","gene":"SLC38A10","description":"Putative sodium-dependent amino acid/proton antiporter.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.2771178356217819,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.708333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.65230000201429,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3777)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/publications"},"_namespace":null},{"id":3778,"version":2,"created":1554880502000,"modified":1554880505000,"deprecated":false,"name":"Forkhead box protein E3","accession":"Q13461","gene":"FOXE3","description":"Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5370102673467352,"antibodyCount":150,"monoclonalCount":0,"pubmedCount":null,"jensenScore":31.543689,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.844476144550917,"pubTatorScore":1.4768083196872606,"self":"https://pharos.nih.gov/idg/api/v1/targets(3778)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/properties"},"_links":{"count":628,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/publications"},"_namespace":null},{"id":3779,"version":2,"created":1554880505000,"modified":1554880508000,"deprecated":false,"name":"Protein FAM172A","accession":"Q8WUF8","gene":"FAM172A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8822398512760321,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.60212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.90106701868642,"pubTatorScore":0.8091854541722678,"self":"https://pharos.nih.gov/idg/api/v1/targets(3779)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/publications"},"_namespace":null},{"id":3780,"version":3,"created":1554880508000,"modified":1555034990000,"deprecated":false,"name":"Frizzled-5","accession":"Q13467","gene":"FZD5","description":"Receptor for Wnt proteins. 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Interacts specifically with Wnt5A to induce the beta-catenin pathway.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.549241895088374,"antibodyCount":307,"monoclonalCount":41,"pubmedCount":null,"jensenScore":30.549361,"patentCount":7363,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.18168485932191,"pubTatorScore":1.3952682618773533,"self":"https://pharos.nih.gov/idg/api/v1/targets(3780)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/publications"},"_namespace":null},{"id":3781,"version":3,"created":1554880512000,"modified":1555034992000,"deprecated":false,"name":"Branched-chain-amino-acid aminotransferase, cytosolic","accession":"P54687","gene":"BCAT1","description":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.8865864759455342,"antibodyCount":216,"monoclonalCount":20,"pubmedCount":null,"jensenScore":78.087049,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":44.84462864291546,"pubTatorScore":1.5835504440958579,"self":"https://pharos.nih.gov/idg/api/v1/targets(3781)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/properties"},"_links":{"count":1079,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/publications"},"_namespace":null},{"id":3782,"version":2,"created":1554880518000,"modified":1554880521000,"deprecated":false,"name":"RelA-associated inhibitor","accession":"Q8WUF5","gene":"PPP1R13L","description":"Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7613062018504857,"antibodyCount":185,"monoclonalCount":11,"pubmedCount":null,"jensenScore":64.541084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.40324271872569,"pubTatorScore":1.8285692844911037,"self":"https://pharos.nih.gov/idg/api/v1/targets(3782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/publications"},"_namespace":null},{"id":3783,"version":2,"created":1554880522000,"modified":1554880524000,"deprecated":false,"name":"MDS1 and EVI1 complex locus protein MDS1","accession":"Q13465","gene":"MECOM","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8405952464351278,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":124.51994,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.01900411149362,"pubTatorScore":2.365201894660987,"self":"https://pharos.nih.gov/idg/api/v1/targets(3783)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/properties"},"_links":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/publications"},"_namespace":null},{"id":3784,"version":3,"created":1554880524000,"modified":1555034994000,"deprecated":false,"name":"Death-associated protein kinase 1","accession":"P53355","gene":"DAPK1","description":"Isoform 2 cannot induce apoptosis but can induce membrane blebbing.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.341526874088907,"antibodyCount":276,"monoclonalCount":30,"pubmedCount":null,"jensenScore":226.06942,"patentCount":11312,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":52.38339282743986,"pubTatorScore":2.4879233100889064,"self":"https://pharos.nih.gov/idg/api/v1/targets(3784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":613,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/properties"},"_links":{"count":1194,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/links"},"_synonyms":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/synonyms"},"_publications":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/publications"},"_namespace":null},{"id":3785,"version":2,"created":1554880530000,"modified":1554880531000,"deprecated":false,"name":"Potassium channel subfamily U member 1","accession":"A8MYU2","gene":"KCNU1","description":"Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.6577159207132586,"antibodyCount":45,"monoclonalCount":42,"pubmedCount":null,"jensenScore":43.300305,"patentCount":2762,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.5918035943183,"pubTatorScore":1.1487054174494093,"self":"https://pharos.nih.gov/idg/api/v1/targets(3785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/properties"},"_links":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/publications"},"_namespace":null},{"id":3786,"version":4,"created":1554880532000,"modified":1555034997000,"deprecated":false,"name":"Serine/threonine-protein kinase PLK1","accession":"P53350","gene":"PLK1","description":"Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.0961018918649352,"antibodyCount":856,"monoclonalCount":337,"pubmedCount":null,"jensenScore":1271.145831,"patentCount":74781,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":56.48273228360455,"pubTatorScore":2.9693791295019953,"self":"https://pharos.nih.gov/idg/api/v1/targets(3786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/properties"},"_links":{"count":1706,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/links"},"_synonyms":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/synonyms"},"_publications":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/publications"},"_namespace":null},{"id":3787,"version":2,"created":1554880603000,"modified":1554880607000,"deprecated":false,"name":"Nuclear factor of activated T-cells, cytoplasmic 2","accession":"Q13469","gene":"NFATC2","description":"Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. 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Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.7747199307306714,"antibodyCount":68,"monoclonalCount":33,"pubmedCount":null,"jensenScore":57.98608,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.732174802061074,"pubTatorScore":1.642146161689682,"self":"https://pharos.nih.gov/idg/api/v1/targets(3825)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/publications"},"_namespace":null},{"id":3826,"version":3,"created":1554880749000,"modified":1555035032000,"deprecated":false,"name":"Collagen alpha-2(VIII) chain","accession":"P25067","gene":"COL8A2","description":"Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.957355194965767,"antibodyCount":93,"monoclonalCount":8,"pubmedCount":null,"jensenScore":89.481895,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":33.4551226647167,"pubTatorScore":1.9909006140260868,"self":"https://pharos.nih.gov/idg/api/v1/targets(3826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/publications"},"_namespace":null},{"id":3827,"version":3,"created":1554880753000,"modified":1555035035000,"deprecated":false,"name":"Cell division cycle protein 20 homolog","accession":"Q12834","gene":"CDC20","description":"Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. 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CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.604088533797081,"antibodyCount":393,"monoclonalCount":150,"pubmedCount":null,"jensenScore":401.481957,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":45.76102665314212,"pubTatorScore":2.3463574816997106,"self":"https://pharos.nih.gov/idg/api/v1/targets(3827)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/links"},"_synonyms":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/synonyms"},"_publications":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/publications"},"_namespace":null},{"id":3828,"version":2,"created":1554880760000,"modified":1554880763000,"deprecated":false,"name":"Signal transducer CD24","accession":"P25063","gene":"CD24","description":"May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.04011718678892,"pubTatorScore":2.777508591834427,"self":"https://pharos.nih.gov/idg/api/v1/targets(3828)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/properties"},"_links":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/synonyms"},"_publications":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/publications"},"_namespace":null},{"id":3829,"version":2,"created":1554880764000,"modified":1554880766000,"deprecated":false,"name":"POU domain, class 4, transcription factor 2","accession":"Q12837","gene":"POU4F2","description":"Isoform 2: Acts either as a transcriptional activator or repressor (PubMed:23805044). Stimulates the promoter activity of the neuronal nicotinic acetylcholine receptor alpha CHRNA2. Negatively regulates the apoptosis regulator BAX promoter activity. Inhibits promoter activity of the neuronal intermediate filament protein alpha-internexin INA gene. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Inhibits the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors TP53 to potentiate transcriptional activation of BAX promoter activity, and hence increases neuronal cell apoptosis. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Acts also as a transcriptional coactivator via its interaction with the transcription factor ESR1 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9439672794490086,"antibodyCount":145,"monoclonalCount":0,"pubmedCount":null,"jensenScore":90.165125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.6181788215852,"pubTatorScore":1.656272191734912,"self":"https://pharos.nih.gov/idg/api/v1/targets(3829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/properties"},"_links":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/publications"},"_namespace":null},{"id":3830,"version":2,"created":1554880766000,"modified":1554880767000,"deprecated":false,"name":"Zona pellucida sperm-binding protein 4","accession":"Q12836","gene":"ZP4","description":"The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.122174437699093,"antibodyCount":123,"monoclonalCount":0,"pubmedCount":null,"jensenScore":132.11768,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.360705020261705,"pubTatorScore":1.6839099758537412,"self":"https://pharos.nih.gov/idg/api/v1/targets(3830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/properties"},"_links":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/publications"},"_namespace":null},{"id":3831,"version":2,"created":1554880767000,"modified":1554880790000,"deprecated":false,"name":"Angiotensin-converting enzyme 2","accession":"Q9BYF1","gene":"ACE2","description":"(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.0018845781692507,"antibodyCount":720,"monoclonalCount":112,"pubmedCount":null,"jensenScore":1129.290761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.06611125884824,"pubTatorScore":2.6826468524812337,"self":"https://pharos.nih.gov/idg/api/v1/targets(3831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/synonyms"},"_publications":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/publications"},"_namespace":null},{"id":3832,"version":2,"created":1554880791000,"modified":1554880792000,"deprecated":false,"name":"Stress-responsive DNAJB4-interacting membrane protein 1","accession":"Q6ZPB5","gene":"SDIM1","description":"Promotes neuronal cells survival to stress conditions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.6020599913279624,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.978454841663302,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/links"},"_synonyms":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/publications"},"_namespace":null},{"id":3833,"version":3,"created":1554880792000,"modified":1555035037000,"deprecated":false,"name":"MARCKS-related protein","accession":"P49006","gene":"MARCKSL1","description":"Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6416185165785717,"antibodyCount":171,"monoclonalCount":36,"pubmedCount":null,"jensenScore":43.579405,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":39.41191294616781,"pubTatorScore":1.8812972697557746,"self":"https://pharos.nih.gov/idg/api/v1/targets(3833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/publications"},"_namespace":null},{"id":3834,"version":3,"created":1554880796000,"modified":1555035038000,"deprecated":false,"name":"DNA polymerase delta subunit 2","accession":"P49005","gene":"POLD2","description":"As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9522242496304052,"antibodyCount":115,"monoclonalCount":15,"pubmedCount":null,"jensenScore":8.518196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":40.8416603934872,"pubTatorScore":0.8646086676923714,"self":"https://pharos.nih.gov/idg/api/v1/targets(3834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/properties"},"_links":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/publications"},"_namespace":null},{"id":3835,"version":2,"created":1554880800000,"modified":1554880803000,"deprecated":false,"name":"Kinesin heavy chain isoform 5A","accession":"Q12840","gene":"KIF5A","description":"Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6913052109592885,"antibodyCount":170,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.376817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.020517162676434,"pubTatorScore":1.7600863859081157,"self":"https://pharos.nih.gov/idg/api/v1/targets(3835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/publications"},"_namespace":null},{"id":3836,"version":2,"created":1554880804000,"modified":1554880808000,"deprecated":false,"name":"Follistatin-related protein 1","accession":"Q12841","gene":"FSTL1","description":"May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.980381133167249,"antibodyCount":265,"monoclonalCount":23,"pubmedCount":null,"jensenScore":117.500442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.53893155379848,"pubTatorScore":1.7002240587341075,"self":"https://pharos.nih.gov/idg/api/v1/targets(3836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/publications"},"_namespace":null},{"id":3837,"version":3,"created":1554880809000,"modified":1555035040000,"deprecated":false,"name":"Replication protein A 70 kDa DNA-binding subunit","accession":"P27694","gene":"RPA1","description":"As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.4827697822616424,"antibodyCount":350,"monoclonalCount":115,"pubmedCount":null,"jensenScore":297.924695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":51.55511973571242,"pubTatorScore":2.5856927511057703,"self":"https://pharos.nih.gov/idg/api/v1/targets(3837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":729,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/properties"},"_links":{"count":1335,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/links"},"_synonyms":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/synonyms"},"_publications":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/publications"},"_namespace":null},{"id":3838,"version":3,"created":1554880831000,"modified":1555035042000,"deprecated":false,"name":"DNA-(apurinic or apyrimidinic site) lyase","accession":"P27695","gene":"APEX1","description":"Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.4774644829533763,"antibodyCount":646,"monoclonalCount":152,"pubmedCount":null,"jensenScore":2988.977491,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.738231689575386,"pubTatorScore":3.0769839006505904,"self":"https://pharos.nih.gov/idg/api/v1/targets(3838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/properties"},"_links":{"count":1755,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/synonyms"},"_publications":{"count":527,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/publications"},"_namespace":null},{"id":3839,"version":3,"created":1554880842000,"modified":1555035046000,"deprecated":false,"name":"Cadherin-related family member 2","accession":"Q9BYE9","gene":"CDHR2","description":"Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7236901795289912,"antibodyCount":30,"monoclonalCount":6,"pubmedCount":null,"jensenScore":6.090013,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":31.2564381999471,"pubTatorScore":0.7403626894942439,"self":"https://pharos.nih.gov/idg/api/v1/targets(3839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/publications"},"_namespace":null},{"id":3840,"version":2,"created":1554880845000,"modified":1554880848000,"deprecated":false,"name":"G-rich sequence factor 1","accession":"Q12849","gene":"GRSF1","description":"Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0558528018184767,"antibodyCount":138,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.95564,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.56006171290958,"pubTatorScore":1.0848739982192874,"self":"https://pharos.nih.gov/idg/api/v1/targets(3840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/publications"},"_namespace":null},{"id":3841,"version":3,"created":1554880849000,"modified":1555035049000,"deprecated":false,"name":"Polycomb group RING finger protein 6","accession":"Q9BYE7","gene":"PCGF6","description":"Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8267967682016752,"antibodyCount":112,"monoclonalCount":7,"pubmedCount":null,"jensenScore":8.452229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":32.38121829621317,"pubTatorScore":0.3708545435793626,"self":"https://pharos.nih.gov/idg/api/v1/targets(3841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/publications"},"_namespace":null},{"id":3842,"version":3,"created":1554880851000,"modified":1555035050000,"deprecated":false,"name":"Syntaxin-4","accession":"Q12846","gene":"STX4","description":"Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9529472053968262,"antibodyCount":207,"monoclonalCount":50,"pubmedCount":null,"jensenScore":84.172062,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":44.57656170840945,"pubTatorScore":1.8746923328128302,"self":"https://pharos.nih.gov/idg/api/v1/targets(3842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/publications"},"_namespace":null},{"id":3843,"version":2,"created":1554880856000,"modified":1554880857000,"deprecated":false,"name":"Transcription factor HES-7","accession":"Q9BYE0","gene":"HES7","description":"Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3604699838556964,"antibodyCount":144,"monoclonalCount":0,"pubmedCount":null,"jensenScore":22.625486,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.004540012882845,"pubTatorScore":1.1937814172577421,"self":"https://pharos.nih.gov/idg/api/v1/targets(3843)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/publications"},"_namespace":null},{"id":3844,"version":2,"created":1554880858000,"modified":1554880861000,"deprecated":false,"name":"Nuclear receptor subfamily 2 group C member 1","accession":"P13056","gene":"NR2C1","description":"Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.","idgFamily":"Nuclear Receptor","idgTDL":"Tbio","novelty":-1.391823896267129,"antibodyCount":294,"monoclonalCount":99,"pubmedCount":null,"jensenScore":24.356992,"patentCount":15193,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.72387488611102,"pubTatorScore":1.9394325398147267,"self":"https://pharos.nih.gov/idg/api/v1/targets(3844)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/publications"},"_namespace":null},{"id":3845,"version":3,"created":1554880861000,"modified":1555035051000,"deprecated":false,"name":"Serine/threonine-protein kinase receptor R3","accession":"P37023","gene":"ACVRL1","description":"Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.9837022431853213,"antibodyCount":432,"monoclonalCount":103,"pubmedCount":null,"jensenScore":969.840322,"patentCount":38459,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.15884508689677,"pubTatorScore":2.4093319006630884,"self":"https://pharos.nih.gov/idg/api/v1/targets(3845)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":550,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/properties"},"_links":{"count":1116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/synonyms"},"_publications":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/publications"},"_namespace":null},{"id":3846,"version":3,"created":1554880887000,"modified":1555035053000,"deprecated":false,"name":"Carboxypeptidase M","accession":"P14384","gene":"CPM","description":"Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.144740165864397,"antibodyCount":196,"monoclonalCount":33,"pubmedCount":null,"jensenScore":133.188197,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.377709575265975,"pubTatorScore":1.7888751087137178,"self":"https://pharos.nih.gov/idg/api/v1/targets(3846)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/publications"},"_namespace":null},{"id":3847,"version":2,"created":1554880892000,"modified":1554880896000,"deprecated":false,"name":"Acidic leucine-rich nuclear phosphoprotein 32 family member A","accession":"P39687","gene":"ANP32A","description":"Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1609891804207404,"antibodyCount":382,"monoclonalCount":58,"pubmedCount":null,"jensenScore":153.605903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.4173501199152,"pubTatorScore":1.918781058975526,"self":"https://pharos.nih.gov/idg/api/v1/targets(3847)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/publications"},"_namespace":null},{"id":3848,"version":2,"created":1554880897000,"modified":1554880902000,"deprecated":false,"name":"Uracil-DNA glycosylase","accession":"P13051","gene":"UNG","description":"Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.8295681214594923,"antibodyCount":352,"monoclonalCount":119,"pubmedCount":null,"jensenScore":680.854469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.303815537405676,"pubTatorScore":2.6683525707268707,"self":"https://pharos.nih.gov/idg/api/v1/targets(3848)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/properties"},"_links":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/synonyms"},"_publications":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/publications"},"_namespace":null},{"id":3849,"version":2,"created":1554880903000,"modified":1554880904000,"deprecated":false,"name":"Small proline-rich protein 2G","accession":"Q9BYE4","gene":"SPRR2G","description":"Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.39222014925042364,"antibodyCount":1,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.305195,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.15302796143528,"pubTatorScore":-0.0917708076503444,"self":"https://pharos.nih.gov/idg/api/v1/targets(3849)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/properties"},"_links":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/publications"},"_namespace":null},{"id":3850,"version":2,"created":1554880904000,"modified":1554880906000,"deprecated":false,"name":"Late cornified envelope protein 3D","accession":"Q9BYE3","gene":"LCE3D","description":"Precursors of the cornified envelope of the stratum corneum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.13175072010915284,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.113967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.116187403946512,"pubTatorScore":0.06356264493942214,"self":"https://pharos.nih.gov/idg/api/v1/targets(3850)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/properties"},"_links":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/publications"},"_namespace":null},{"id":3851,"version":2,"created":1554880906000,"modified":1554880908000,"deprecated":false,"name":"Transmembrane protease serine 13","accession":"Q9BYE2","gene":"TMPRSS13","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7763426239123632,"antibodyCount":71,"monoclonalCount":6,"pubmedCount":null,"jensenScore":56.800298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.53831260571199,"pubTatorScore":1.5429439147012267,"self":"https://pharos.nih.gov/idg/api/v1/targets(3851)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/publications"},"_namespace":null},{"id":3852,"version":3,"created":1554880908000,"modified":1554881052000,"deprecated":false,"name":"C-X-C chemokine receptor type 2","accession":"P25025","gene":"CXCR2","description":"Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.8731318593663167,"antibodyCount":643,"monoclonalCount":288,"pubmedCount":null,"jensenScore":723.905403,"patentCount":57672,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.614421934844756,"pubTatorScore":2.665099198225467,"self":"https://pharos.nih.gov/idg/api/v1/targets(3852)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":633,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/properties"},"_links":{"count":1490,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/synonyms"},"_publications":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/publications"},"_namespace":null},{"id":3853,"version":2,"created":1554881055000,"modified":1554881064000,"deprecated":false,"name":"DNA (cytosine-5)-methyltransferase 1","accession":"P26358","gene":"DNMT1","description":"Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). 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Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.6042301015965006,"antibodyCount":193,"monoclonalCount":3,"pubmedCount":null,"jensenScore":35.275727,"patentCount":9397,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.31730898005464,"pubTatorScore":0.8687423346143607,"self":"https://pharos.nih.gov/idg/api/v1/targets(3854)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/publications"},"_namespace":null},{"id":3855,"version":2,"created":1554881072000,"modified":1554881074000,"deprecated":false,"name":"Rab proteins geranylgeranyltransferase component A 2","accession":"P26374","gene":"CHML","description":"Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. 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Less effective than CHM in supporting prenylation of Rab3 family.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9013739231619304,"antibodyCount":126,"monoclonalCount":12,"pubmedCount":null,"jensenScore":73.297913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.56396952166738,"pubTatorScore":1.5624653581411643,"self":"https://pharos.nih.gov/idg/api/v1/targets(3855)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/publications"},"_namespace":null},{"id":3856,"version":3,"created":1554881075000,"modified":1554881214000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 12","accession":"Q12852","gene":"MAP3K12","description":"May be an activator of the JNK/SAPK pathway. 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The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4393326981732075,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.916667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.112572776527776,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3858)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/properties"},"_links":{"count":680,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/publications"},"_namespace":null},{"id":3859,"version":3,"created":1554881221000,"modified":1555035055000,"deprecated":false,"name":"60S ribosomal protein L13","accession":"P26373","gene":"RPL13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5533149867260796,"antibodyCount":96,"monoclonalCount":12,"pubmedCount":null,"jensenScore":34.990386,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":42.694659989651264,"pubTatorScore":1.2968218808842387,"self":"https://pharos.nih.gov/idg/api/v1/targets(3859)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/properties"},"_links":{"count":1157,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/publications"},"_namespace":null},{"id":3860,"version":2,"created":1554881225000,"modified":1554881227000,"deprecated":false,"name":"39S ribosomal protein L1, mitochondrial","accession":"Q9BYD6","gene":"MRPL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7444817778719438,"antibodyCount":128,"monoclonalCount":12,"pubmedCount":null,"jensenScore":4.180123,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.11503667096846,"pubTatorScore":0.08184901334835865,"self":"https://pharos.nih.gov/idg/api/v1/targets(3860)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/publications"},"_namespace":null},{"id":3861,"version":2,"created":1554881228000,"modified":1554881232000,"deprecated":false,"name":"Nuclear factor 1 A-type","accession":"Q12857","gene":"NFIA","description":"Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. 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May also be involved in the assembly of the 'E' complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.295176590782753,"antibodyCount":78,"monoclonalCount":11,"pubmedCount":null,"jensenScore":20.117023,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.122804151794085,"pubTatorScore":0.9540981066472801,"self":"https://pharos.nih.gov/idg/api/v1/targets(3887)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/publications"},"_namespace":null},{"id":3888,"version":3,"created":1554881398000,"modified":1555035080000,"deprecated":false,"name":"Splicing factor, suppressor of white-apricot homolog","accession":"Q12872","gene":"SFSWAP","description":"Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3979400086720376,"antibodyCount":147,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.818507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":40.46794380182579,"pubTatorScore":1.2409650483752852,"self":"https://pharos.nih.gov/idg/api/v1/targets(3888)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/publications"},"_namespace":null},{"id":3889,"version":2,"created":1554881401000,"modified":1554881404000,"deprecated":false,"name":"Ral GTPase-activating protein subunit alpha-1","accession":"Q6GYQ0","gene":"RALGAPA1","description":"Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.56324247486823,"antibodyCount":56,"monoclonalCount":12,"pubmedCount":null,"jensenScore":36.816583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.06571876803404,"pubTatorScore":1.0380900628690395,"self":"https://pharos.nih.gov/idg/api/v1/targets(3889)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/publications"},"_namespace":null},{"id":3890,"version":2,"created":1554881405000,"modified":1554881408000,"deprecated":false,"name":"Telomere repeats-binding bouquet formation protein 1","accession":"Q8NA31","gene":"TERB1","description":"Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.45229766665168547,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.562467,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3890)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/properties"},"_links":{"count":712,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/publications"},"_namespace":null},{"id":3891,"version":3,"created":1554881408000,"modified":1555035083000,"deprecated":false,"name":"Glutamate receptor ionotropic, NMDA 2A","accession":"Q12879","gene":"GRIN2A","description":"Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-3.0982801998050182,"antibodyCount":555,"monoclonalCount":164,"pubmedCount":null,"jensenScore":1158.102031,"patentCount":14768,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":51.94187303312502,"pubTatorScore":2.6031651262019975,"self":"https://pharos.nih.gov/idg/api/v1/targets(3891)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/synonyms"},"_publications":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/publications"},"_namespace":null},{"id":3892,"version":2,"created":1554881416000,"modified":1554881418000,"deprecated":false,"name":"Tripartite motif-containing protein 34","accession":"Q9BYJ4","gene":"TRIM34","description":"May function as antiviral protein and may contribute to the defense against retroviral infections.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2018520875422818,"antibodyCount":78,"monoclonalCount":4,"pubmedCount":null,"jensenScore":9.984038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.164050739322487,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(3892)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/properties"},"_links":{"count":727,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/publications"},"_namespace":null},{"id":3893,"version":2,"created":1554881419000,"modified":1554881421000,"deprecated":false,"name":"Sodium-dependent lysophosphatidylcholine symporter 1","accession":"Q8NA29","gene":"MFSD2A","description":"Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:26005868). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed:21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732, PubMed:23177091).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4017514413102814,"antibodyCount":73,"monoclonalCount":2,"pubmedCount":null,"jensenScore":26.333181,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.08957126560373,"pubTatorScore":1.562670393734591,"self":"https://pharos.nih.gov/idg/api/v1/targets(3893)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/publications"},"_namespace":null},{"id":3894,"version":3,"created":1554881422000,"modified":1555035084000,"deprecated":false,"name":"YTH domain-containing family protein 1","accession":"Q9BYJ9","gene":"YTHDF1","description":"Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7648519040170976,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.255195,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.36241041882738,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(3894)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/properties"},"_links":{"count":929,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/publications"},"_namespace":null},{"id":3895,"version":3,"created":1554881425000,"modified":1555035086000,"deprecated":false,"name":"Hydroperoxide isomerase ALOXE3","accession":"Q9BYJ1","gene":"ALOXE3","description":"Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.511199213168452,"antibodyCount":118,"monoclonalCount":2,"pubmedCount":null,"jensenScore":32.190304,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":31.75114930771382,"pubTatorScore":1.3855566039117873,"self":"https://pharos.nih.gov/idg/api/v1/targets(3895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/properties"},"_links":{"count":824,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/publications"},"_namespace":null},{"id":3896,"version":2,"created":1554881428000,"modified":1554881430000,"deprecated":false,"name":"Fibroblast growth factor-binding protein 2","accession":"Q9BYJ0","gene":"FGFBP2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8021720520296401,"antibodyCount":63,"monoclonalCount":4,"pubmedCount":null,"jensenScore":7.36045,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.524781665224467,"pubTatorScore":0.9022941192927291,"self":"https://pharos.nih.gov/idg/api/v1/targets(3896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/publications"},"_namespace":null},{"id":3897,"version":2,"created":1554881430000,"modified":1554881460000,"deprecated":false,"name":"Prolyl endopeptidase FAP","accession":"Q12884","gene":"FAP","description":"Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3768644682926006,"antibodyCount":406,"monoclonalCount":70,"pubmedCount":null,"jensenScore":226.211055,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.204481222187184,"pubTatorScore":2.4180636158279176,"self":"https://pharos.nih.gov/idg/api/v1/targets(3897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/publications"},"_namespace":null},{"id":3898,"version":2,"created":1554881461000,"modified":1554881469000,"deprecated":false,"name":"Dihydropyrimidine dehydrogenase [NADP(+)]","accession":"Q12882","gene":"DPYD","description":"Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.6243181003406253,"antibodyCount":159,"monoclonalCount":28,"pubmedCount":null,"jensenScore":395.040854,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.82179117493261,"pubTatorScore":2.9352470056604907,"self":"https://pharos.nih.gov/idg/api/v1/targets(3898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/properties"},"_links":{"count":1197,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/publications"},"_namespace":null},{"id":3899,"version":2,"created":1554881471000,"modified":1554881472000,"deprecated":false,"name":"Aminopeptidase Q","accession":"Q6Q4G3","gene":"LVRN","description":"Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9310783172933055,"antibodyCount":15,"monoclonalCount":1,"pubmedCount":null,"jensenScore":81.302588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.687432273123182,"pubTatorScore":1.1865207778526312,"self":"https://pharos.nih.gov/idg/api/v1/targets(3899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/publications"},"_namespace":null},{"id":3900,"version":2,"created":1554881473000,"modified":1554881478000,"deprecated":false,"name":"TP53-binding protein 1","accession":"Q12888","gene":"TP53BP1","description":"Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.694850775022812,"antibodyCount":577,"monoclonalCount":104,"pubmedCount":null,"jensenScore":464.845443,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.04183098347208,"pubTatorScore":2.4859846370241807,"self":"https://pharos.nih.gov/idg/api/v1/targets(3900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":689,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/properties"},"_links":{"count":1363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/synonyms"},"_publications":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/publications"},"_namespace":null},{"id":3901,"version":3,"created":1554881479000,"modified":1555035087000,"deprecated":false,"name":"Radial spoke head protein 4 homolog A","accession":"Q5TD94","gene":"RSPH4A","description":"Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. 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May also have a role in the beta-catenin/Lef signaling pathway (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9530920424361135,"antibodyCount":51,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.494372,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.708085849395026,"pubTatorScore":1.136984645678016,"self":"https://pharos.nih.gov/idg/api/v1/targets(3911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/publications"},"_namespace":null},{"id":3912,"version":3,"created":1554881614000,"modified":1555035108000,"deprecated":false,"name":"Four and a half LIM domains protein 5","accession":"Q5TD97","gene":"FHL5","description":"May be involved in the regulation of spermatogenesis. 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In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3022912794081636,"antibodyCount":351,"monoclonalCount":135,"pubmedCount":null,"jensenScore":2035.033915,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.951659414870655,"pubTatorScore":3.1769970081508943,"self":"https://pharos.nih.gov/idg/api/v1/targets(3997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/properties"},"_links":{"count":1622,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/synonyms"},"_publications":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/publications"},"_namespace":null},{"id":3998,"version":3,"created":1554882265000,"modified":1555035198000,"deprecated":false,"name":"Complement C3","accession":"P01024","gene":"C3","description":"Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.5596262481836436,"antibodyCount":1079,"monoclonalCount":501,"pubmedCount":null,"jensenScore":3446.071636,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.88438700142456,"pubTatorScore":3.62253880942313,"self":"https://pharos.nih.gov/idg/api/v1/targets(3998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/properties"},"_links":{"count":1543,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/links"},"_synonyms":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/synonyms"},"_publications":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/publications"},"_namespace":null},{"id":3999,"version":3,"created":1554882275000,"modified":1555035201000,"deprecated":false,"name":"Alpha-2-macroglobulin","accession":"P01023","gene":"A2M","description":"Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9607326535296017,"antibodyCount":642,"monoclonalCount":138,"pubmedCount":null,"jensenScore":801.946106,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":45.894234851421494,"pubTatorScore":3.3914515801254885,"self":"https://pharos.nih.gov/idg/api/v1/targets(3999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/properties"},"_links":{"count":1177,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/publications"},"_namespace":null},{"id":4000,"version":2,"created":1554882281000,"modified":1554882306000,"deprecated":false,"name":"Maltase-glucoamylase, intestinal","accession":"O43451","gene":"MGAM","description":"May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-4.5215778122599195,"antibodyCount":32,"monoclonalCount":3,"pubmedCount":null,"jensenScore":32564.428262,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.05224102713403,"pubTatorScore":1.9135026801582784,"self":"https://pharos.nih.gov/idg/api/v1/targets(4000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/publications"},"_namespace":null}]}
{"id":327291,"version":1,"created":1584652229267,"modified":1584652229273,"deprecated":false,"etag":"cf6f64e6002a68da","uri":"https://pharos.nih.gov/idg/api/v1/targets?top=1000&skip=4000","path":"/idg/api/v1/targets","method":"GET","sha1":"97018d676813cb41bf1f03d84edfcc589327cc0f","total":20244,"count":1000,"skip":4000,"top":1000,"status":null,"query":"skip=4000&top=1000","filter":null,"_namespace":null,"content":[{"id":4001,"version":3,"created":1554882307000,"modified":1555035203000,"deprecated":false,"name":"Alpha-globin transcription factor CP2","accession":"Q12800","gene":"TFCP2","description":"Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4486524880975296,"antibodyCount":137,"monoclonalCount":14,"pubmedCount":null,"jensenScore":285.495639,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.3265032220328,"pubTatorScore":1.8120364197259278,"self":"https://pharos.nih.gov/idg/api/v1/targets(4001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/publications"},"_namespace":null},{"id":4002,"version":3,"created":1554882311000,"modified":1555035205000,"deprecated":false,"name":"UV-stimulated scaffold protein A","accession":"Q2YD98","gene":"UVSSA","description":"Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8502376814762282,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.928802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.87857380120854,"pubTatorScore":0.9353393095108588,"self":"https://pharos.nih.gov/idg/api/v1/targets(4002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/publications"},"_namespace":null},{"id":4003,"version":3,"created":1554882314000,"modified":1555035206000,"deprecated":false,"name":"EGF-containing fibulin-like extracellular matrix protein 1","accession":"Q12805","gene":"EFEMP1","description":"Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1730529474432165,"antibodyCount":259,"monoclonalCount":30,"pubmedCount":null,"jensenScore":162.559488,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":29,"knowledgeAvailability":39.10477481206375,"pubTatorScore":2.08554800250724,"self":"https://pharos.nih.gov/idg/api/v1/targets(4003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/publications"},"_namespace":null},{"id":4004,"version":3,"created":1554882319000,"modified":1555035208000,"deprecated":false,"name":"A-kinase anchor protein 13","accession":"Q12802","gene":"AKAP13","description":"Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4675603119343443,"antibodyCount":156,"monoclonalCount":47,"pubmedCount":null,"jensenScore":291.706901,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":52.72644423905185,"pubTatorScore":1.9853382274376425,"self":"https://pharos.nih.gov/idg/api/v1/targets(4004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/publications"},"_namespace":null},{"id":4005,"version":3,"created":1554882324000,"modified":1555035210000,"deprecated":false,"name":"Frizzled-1","accession":"Q9UP38","gene":"FZD1","description":"Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-2.070485540008074,"antibodyCount":286,"monoclonalCount":46,"pubmedCount":null,"jensenScore":78.415047,"patentCount":9908,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.961957127636886,"pubTatorScore":1.520565523467197,"self":"https://pharos.nih.gov/idg/api/v1/targets(4005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/publications"},"_namespace":null},{"id":4006,"version":3,"created":1554882328000,"modified":1554883782000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily H member 2","accession":"Q12809","gene":"KCNH2","description":"Isoform B-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-3.2257531837523574,"antibodyCount":243,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1653.894888,"patentCount":63697,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.5616183168717,"pubTatorScore":3.137747717128631,"self":"https://pharos.nih.gov/idg/api/v1/targets(4006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/properties"},"_links":{"count":5844,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/synonyms"},"_publications":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/publications"},"_namespace":null},{"id":4007,"version":2,"created":1554883794000,"modified":1554883794000,"deprecated":false,"name":"Olfactory receptor 11H12","accession":"B2RN74","gene":"OR11H12","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":59,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.02425067207426,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/properties"},"_links":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/publications"},"_namespace":null},{"id":4008,"version":3,"created":1554883794000,"modified":1555035212000,"deprecated":false,"name":"X-ray repair cross-complementing protein 5","accession":"P13010","gene":"XRCC5","description":"Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.686217116844803,"antibodyCount":874,"monoclonalCount":327,"pubmedCount":null,"jensenScore":470.815482,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":53.955131356933244,"pubTatorScore":2.5674924634882075,"self":"https://pharos.nih.gov/idg/api/v1/targets(4008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/properties"},"_links":{"count":1419,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/synonyms"},"_publications":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/publications"},"_namespace":null},{"id":4009,"version":3,"created":1554883800000,"modified":1555035215000,"deprecated":false,"name":"Histone-lysine N-methyltransferase SUV39H1","accession":"O43463","gene":"SUV39H1","description":"Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. 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In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7848593971949154,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":61.879752,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.55988886928504,"pubTatorScore":1.3615929571972907,"self":"https://pharos.nih.gov/idg/api/v1/targets(4028)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(4028)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(4028)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4028)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(4028)/publications"},"_namespace":null},{"id":4029,"version":3,"created":1554883862000,"modified":1555035222000,"deprecated":false,"name":"Tumor necrosis factor ligand superfamily member 14","accession":"O43557","gene":"TNFSF14","description":"Cytokine that binds to TNFRSF3/LTBR. 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Acts as a receptor for Herpes simplex virus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8228821250207077,"antibodyCount":389,"monoclonalCount":130,"pubmedCount":null,"jensenScore":61.355707,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":27.713745991233406,"pubTatorScore":1.8276767183730929,"self":"https://pharos.nih.gov/idg/api/v1/targets(4029)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(4029)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(4029)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(4029)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4029)/publications"},"_namespace":null},{"id":4030,"version":2,"created":1554883865000,"modified":1554883869000,"deprecated":false,"name":"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5","accession":"Q9UPN3","gene":"MACF1","description":"Isoform 2: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). 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Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.052459433246762,"antibodyCount":45,"monoclonalCount":22,"pubmedCount":null,"jensenScore":115.834206,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.05812983668853,"pubTatorScore":1.5073366739757972,"self":"https://pharos.nih.gov/idg/api/v1/targets(4030)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":466,"href":"https://pharos.nih.gov/idg/api/v1/targets(4030)/properties"},"_links":{"count":1170,"href":"https://pharos.nih.gov/idg/api/v1/targets(4030)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(4030)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(4030)/publications"},"_namespace":null},{"id":4031,"version":2,"created":1554883870000,"modified":1554883874000,"deprecated":false,"name":"Epsilon-sarcoglycan","accession":"O43556","gene":"SGCE","description":"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.190420759385119,"antibodyCount":93,"monoclonalCount":2,"pubmedCount":null,"jensenScore":158.328387,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.48834708512489,"pubTatorScore":2.1875488926621607,"self":"https://pharos.nih.gov/idg/api/v1/targets(4031)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(4031)/properties"},"_links":{"count":1094,"href":"https://pharos.nih.gov/idg/api/v1/targets(4031)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(4031)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(4031)/publications"},"_namespace":null},{"id":4032,"version":2,"created":1554883875000,"modified":1554883879000,"deprecated":false,"name":"E3 ubiquitin-protein ligase TRIM33","accession":"Q9UPN9","gene":"TRIM33","description":"Acts as an E3 ubiquitin-protein ligase. 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In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3212423241745221,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.53819,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.94745930938105,"pubTatorScore":1.0037380816602985,"self":"https://pharos.nih.gov/idg/api/v1/targets(4038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(4038)/properties"},"_links":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(4038)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(4038)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(4038)/publications"},"_namespace":null},{"id":4039,"version":2,"created":1554883892000,"modified":1554883894000,"deprecated":false,"name":"Linker for activation of T-cells family member 1","accession":"O43561","gene":"LAT","description":"Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling 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Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9279803652351828,"antibodyCount":269,"monoclonalCount":85,"pubmedCount":null,"jensenScore":88.25084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":44.526606711113956,"pubTatorScore":1.9447630667577631,"self":"https://pharos.nih.gov/idg/api/v1/targets(4110)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(4110)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(4110)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(4110)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(4110)/publications"},"_namespace":null},{"id":4111,"version":2,"created":1554884153000,"modified":1554884156000,"deprecated":false,"name":"B9 domain-containing protein 1","accession":"Q9UPM9","gene":"B9D1","description":"Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6131619890789604,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.721105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.62246144003869,"pubTatorScore":0.583036818834599,"self":"https://pharos.nih.gov/idg/api/v1/targets(4111)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/publications"},"_namespace":null},{"id":4112,"version":2,"created":1554884157000,"modified":1554884160000,"deprecated":false,"name":"Tumor necrosis factor ligand superfamily member 12","accession":"O43508","gene":"TNFSF12","description":"Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. 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Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.180665497530285,"antibodyCount":104,"monoclonalCount":24,"pubmedCount":null,"jensenScore":14.219934,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":40,"knowledgeAvailability":0.0,"pubTatorScore":1.076501687535855,"self":"https://pharos.nih.gov/idg/api/v1/targets(4115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/publications"},"_namespace":null},{"id":4116,"version":3,"created":1554884170000,"modified":1555035285000,"deprecated":false,"name":"LIM/homeobox protein Lhx6","accession":"Q9UPM6","gene":"LHX6","description":"Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. 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Antagonist of PPARA-mediated transactivation.","idgFamily":"Nuclear Receptor","idgTDL":"Tchem","novelty":-1.6896421477381822,"antibodyCount":428,"monoclonalCount":91,"pubmedCount":null,"jensenScore":45.767241,"patentCount":24606,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.45928184590826,"pubTatorScore":1.7884832760553027,"self":"https://pharos.nih.gov/idg/api/v1/targets(4251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":495,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/properties"},"_links":{"count":1062,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/publications"},"_namespace":null},{"id":4252,"version":3,"created":1554884687000,"modified":1555035361000,"deprecated":false,"name":"Serine/threonine-protein phosphatase PP1-alpha catalytic subunit","accession":"P62136","gene":"PPP1CA","description":"Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.170098277709012,"antibodyCount":378,"monoclonalCount":152,"pubmedCount":null,"jensenScore":138.965123,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":53.750061734148915,"pubTatorScore":1.9839547745123438,"self":"https://pharos.nih.gov/idg/api/v1/targets(4252)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":593,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/synonyms"},"_publications":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/publications"},"_namespace":null},{"id":4253,"version":2,"created":1554884692000,"modified":1554884693000,"deprecated":false,"name":"Clarin-2","accession":"A0PK11","gene":"CLRN2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.873234345753584,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4253)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/properties"},"_links":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/publications"},"_namespace":null},{"id":4254,"version":2,"created":1554884693000,"modified":1554884695000,"deprecated":false,"name":"Spermatogenesis-associated protein 16","accession":"Q9BXB7","gene":"SPATA16","description":"Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8549563543774241,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.023229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.45727427645801,"pubTatorScore":1.1077751007128323,"self":"https://pharos.nih.gov/idg/api/v1/targets(4254)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/properties"},"_links":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/links"},"_synonyms":{"count":1537,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/publications"},"_namespace":null},{"id":4255,"version":2,"created":1554884695000,"modified":1554884697000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 10","accession":"Q9BXB5","gene":"OSBPL10","description":"Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6989653574099235,"antibodyCount":127,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.126989,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.08402719573601,"pubTatorScore":0.7767703896181177,"self":"https://pharos.nih.gov/idg/api/v1/targets(4255)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/publications"},"_namespace":null},{"id":4256,"version":2,"created":1554884698000,"modified":1554884701000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 11","accession":"Q9BXB4","gene":"OSBPL11","description":"Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3925992616264472,"antibodyCount":185,"monoclonalCount":62,"pubmedCount":null,"jensenScore":3.031907,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.653917843842414,"pubTatorScore":0.5467112899860862,"self":"https://pharos.nih.gov/idg/api/v1/targets(4256)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/publications"},"_namespace":null},{"id":4257,"version":3,"created":1554884701000,"modified":1555035363000,"deprecated":false,"name":"Serine/threonine-protein phosphatase PP1-beta catalytic subunit","accession":"P62140","gene":"PPP1CB","description":"Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5519180599654543,"antibodyCount":377,"monoclonalCount":58,"pubmedCount":null,"jensenScore":33.307632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":52.17153948574055,"pubTatorScore":1.4370989653804467,"self":"https://pharos.nih.gov/idg/api/v1/targets(4257)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":507,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/publications"},"_namespace":null},{"id":4258,"version":3,"created":1554884706000,"modified":1555035365000,"deprecated":false,"name":"Leucine-rich repeat-containing G-protein coupled receptor 4","accession":"Q9BXB1","gene":"LGR4","description":"Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.7560432121556984,"antibodyCount":230,"monoclonalCount":83,"pubmedCount":null,"jensenScore":72.221856,"patentCount":6748,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":37.86368511709624,"pubTatorScore":1.517872619023379,"self":"https://pharos.nih.gov/idg/api/v1/targets(4258)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/publications"},"_namespace":null},{"id":4259,"version":2,"created":1554884709000,"modified":1554884710000,"deprecated":false,"name":"Transmembrane protein 72","accession":"A0PK05","gene":"TMEM72","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3631779028471202,"antibodyCount":13,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.433333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.75742378143848,"pubTatorScore":0.08754469119603969,"self":"https://pharos.nih.gov/idg/api/v1/targets(4259)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/properties"},"_links":{"count":617,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/publications"},"_namespace":null},{"id":4260,"version":2,"created":1554884711000,"modified":1554884713000,"deprecated":false,"name":"Transmembrane protein 120B","accession":"A0PK00","gene":"TMEM120B","description":"Necessary for efficient adipogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.40576534695952005,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.299145,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.11694622413195,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(4260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/publications"},"_namespace":null},{"id":4261,"version":2,"created":1554884713000,"modified":1554884717000,"deprecated":false,"name":"Polyubiquitin-B","accession":"P0CG47","gene":"UBB","description":"Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9885962018332175,"antibodyCount":427,"monoclonalCount":163,"pubmedCount":null,"jensenScore":97.439641,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.28906105123567,"pubTatorScore":1.9896281176824313,"self":"https://pharos.nih.gov/idg/api/v1/targets(4261)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(4261)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(4261)/links"},"_synonyms":{"count":527,"href":"https://pharos.nih.gov/idg/api/v1/targets(4261)/synonyms"},"_publications":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(4261)/publications"},"_namespace":null},{"id":4262,"version":2,"created":1554884718000,"modified":1554884718000,"deprecated":false,"name":"Putative chemokine-related protein 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Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.118573684915794,"antibodyCount":133,"monoclonalCount":36,"pubmedCount":null,"jensenScore":120.313047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":34.14080191664441,"pubTatorScore":1.0649344408530759,"self":"https://pharos.nih.gov/idg/api/v1/targets(4429)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/publications"},"_namespace":null},{"id":4430,"version":2,"created":1554888644000,"modified":1554888647000,"deprecated":false,"name":"Synaptotagmin-7","accession":"O43581","gene":"SYT7","description":"Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.759305262478777,"antibodyCount":170,"monoclonalCount":68,"pubmedCount":null,"jensenScore":60.314332,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.11661032637718,"pubTatorScore":1.391173197623178,"self":"https://pharos.nih.gov/idg/api/v1/targets(4430)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/publications"},"_namespace":null},{"id":4431,"version":4,"created":1554888648000,"modified":1555035564000,"deprecated":false,"name":"ATP-binding cassette sub-family G member 2","accession":"Q9UNQ0","gene":"ABCG2","description":"High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-3.418767365581369,"antibodyCount":246,"monoclonalCount":137,"pubmedCount":null,"jensenScore":2731.120017,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":49.4031690434656,"pubTatorScore":3.253236050485231,"self":"https://pharos.nih.gov/idg/api/v1/targets(4431)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/properties"},"_links":{"count":1768,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/links"},"_synonyms":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/synonyms"},"_publications":{"count":699,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/publications"},"_namespace":null},{"id":4432,"version":2,"created":1554888714000,"modified":1554888717000,"deprecated":false,"name":"Proline-serine-threonine phosphatase-interacting protein 1","accession":"O43586","gene":"PSTPIP1","description":"Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.898831568972295,"antibodyCount":119,"monoclonalCount":9,"pubmedCount":null,"jensenScore":82.271085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.104776146173535,"pubTatorScore":1.6479108940136782,"self":"https://pharos.nih.gov/idg/api/v1/targets(4432)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/properties"},"_links":{"count":859,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/publications"},"_namespace":null},{"id":4433,"version":3,"created":1554888717000,"modified":1555035570000,"deprecated":false,"name":"Flap endonuclease 1","accession":"P39748","gene":"FEN1","description":"Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.791706479342493,"antibodyCount":406,"monoclonalCount":126,"pubmedCount":null,"jensenScore":616.995314,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":52.45461586048814,"pubTatorScore":2.524267532427015,"self":"https://pharos.nih.gov/idg/api/v1/targets(4433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":595,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/properties"},"_links":{"count":1263,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/synonyms"},"_publications":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/publications"},"_namespace":null},{"id":4434,"version":2,"created":1554888735000,"modified":1554888740000,"deprecated":false,"name":"DNA mismatch repair protein Msh6","accession":"P52701","gene":"MSH6","description":"Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.725936874223874,"antibodyCount":479,"monoclonalCount":208,"pubmedCount":null,"jensenScore":572.307433,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":59.800627479482436,"pubTatorScore":2.7370282812563556,"self":"https://pharos.nih.gov/idg/api/v1/targets(4434)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/properties"},"_links":{"count":1354,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/synonyms"},"_publications":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/publications"},"_namespace":null},{"id":4435,"version":2,"created":1554888742000,"modified":1554888745000,"deprecated":false,"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2","accession":"Q00722","gene":"PLCB2","description":"The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1404756345874145,"antibodyCount":104,"monoclonalCount":10,"pubmedCount":null,"jensenScore":137.848655,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.801357983482774,"pubTatorScore":1.9534221587167033,"self":"https://pharos.nih.gov/idg/api/v1/targets(4435)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":550,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/publications"},"_namespace":null},{"id":4436,"version":2,"created":1554888746000,"modified":1554888746000,"deprecated":false,"name":"Putative uncharacterized protein ATP1A1-AS1","accession":"Q5TC04","gene":"ATP1A1-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.858388134022382,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/properties"},"_links":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/publications"},"_namespace":null},{"id":4437,"version":3,"created":1554888746000,"modified":1555035573000,"deprecated":false,"name":"Protein S100-A4","accession":"P26447","gene":"S100A4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.775671572741567,"antibodyCount":478,"monoclonalCount":130,"pubmedCount":null,"jensenScore":622.249541,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":55,"knowledgeAvailability":35.58355972102706,"pubTatorScore":2.6227659909855965,"self":"https://pharos.nih.gov/idg/api/v1/targets(4437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":601,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/links"},"_synonyms":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/synonyms"},"_publications":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/publications"},"_namespace":null},{"id":4438,"version":3,"created":1554888752000,"modified":1554888851000,"deprecated":false,"name":"Proteinase-activated receptor 1","accession":"P25116","gene":"F2R","description":"High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.7839317919586373,"antibodyCount":453,"monoclonalCount":104,"pubmedCount":null,"jensenScore":550.961553,"patentCount":77288,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.896123683167865,"pubTatorScore":2.8458893700191283,"self":"https://pharos.nih.gov/idg/api/v1/targets(4438)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":748,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/properties"},"_links":{"count":1560,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/synonyms"},"_publications":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/publications"},"_namespace":null},{"id":4439,"version":2,"created":1554888853000,"modified":1554888856000,"deprecated":false,"name":"Anoctamin-4","accession":"Q32M45","gene":"ANO4","description":"Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6303001183881455,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.246989,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.024713833020144,"pubTatorScore":0.6406112090199498,"self":"https://pharos.nih.gov/idg/api/v1/targets(4439)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/properties"},"_links":{"count":753,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/publications"},"_namespace":null},{"id":4440,"version":2,"created":1554888856000,"modified":1554888858000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 3","accession":"Q9BY71","gene":"LRRC3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4756827202120514,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.749972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.79427346538844,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(4440)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/properties"},"_links":{"count":764,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/publications"},"_namespace":null},{"id":4441,"version":2,"created":1554888858000,"modified":1554888862000,"deprecated":false,"name":"BUB3-interacting and GLEBS motif-containing protein ZNF207","accession":"O43670","gene":"ZNF207","description":"Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.821458946403718,"antibodyCount":264,"monoclonalCount":158,"pubmedCount":null,"jensenScore":6.926379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.40616599763821,"pubTatorScore":0.8900016131846367,"self":"https://pharos.nih.gov/idg/api/v1/targets(4441)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/publications"},"_namespace":null},{"id":4442,"version":3,"created":1554888863000,"modified":1555035576000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3","accession":"O43676","gene":"NDUFB3","description":"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.5371191853600467,"antibodyCount":70,"monoclonalCount":33,"pubmedCount":null,"jensenScore":3.235354,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":37.7718018245564,"pubTatorScore":3.680728376074048,"self":"https://pharos.nih.gov/idg/api/v1/targets(4442)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/publications"},"_namespace":null},{"id":4443,"version":3,"created":1554888867000,"modified":1555035577000,"deprecated":false,"name":"Polymerase delta-interacting protein 3","accession":"Q9BY77","gene":"POLDIP3","description":"Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. 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Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.177681121051649,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.25366,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.050617990974786,"pubTatorScore":1.3328077359813306,"self":"https://pharos.nih.gov/idg/api/v1/targets(4490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/publications"},"_namespace":null},{"id":4491,"version":2,"created":1554889010000,"modified":1554889012000,"deprecated":false,"name":"Protein RTF2 homolog","accession":"Q9BY42","gene":"RTF2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":78,"monoclonalCount":28,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4491)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/publications"},"_namespace":null},{"id":4492,"version":3,"created":1554889012000,"modified":1555035617000,"deprecated":false,"name":"Protein regulator of cytokinesis 1","accession":"O43663","gene":"PRC1","description":"Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. 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Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.26145805201421,"antibodyCount":239,"monoclonalCount":31,"pubmedCount":null,"jensenScore":184.76919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":50.771928751319955,"pubTatorScore":2.042470694257048,"self":"https://pharos.nih.gov/idg/api/v1/targets(4511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/properties"},"_links":{"count":1245,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/publications"},"_namespace":null},{"id":4512,"version":2,"created":1554889205000,"modified":1554889208000,"deprecated":false,"name":"CD82 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Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.041392684723930574,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.953968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(4517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/publications"},"_namespace":null},{"id":4518,"version":3,"created":1554889226000,"modified":1555035637000,"deprecated":false,"name":"R-spondin-3","accession":"Q9BXY4","gene":"RSPO3","description":"Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3328606929366345,"antibodyCount":138,"monoclonalCount":20,"pubmedCount":null,"jensenScore":23.209912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.588997697298932,"pubTatorScore":1.207931459950917,"self":"https://pharos.nih.gov/idg/api/v1/targets(4518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/publications"},"_namespace":null},{"id":4519,"version":3,"created":1554889230000,"modified":1555035639000,"deprecated":false,"name":"Nuclear cap-binding protein subunit 1","accession":"Q09161","gene":"NCBP1","description":"Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3413362201199885,"antibodyCount":172,"monoclonalCount":11,"pubmedCount":null,"jensenScore":207.70389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.627015668190666,"pubTatorScore":1.6503846011332794,"self":"https://pharos.nih.gov/idg/api/v1/targets(4519)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/publications"},"_namespace":null},{"id":4520,"version":2,"created":1554889234000,"modified":1554889236000,"deprecated":false,"name":"Protein BEX2","accession":"Q9BXY8","gene":"BEX2","description":"Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase 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Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. 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Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.815737398258812,"antibodyCount":546,"monoclonalCount":174,"pubmedCount":null,"jensenScore":706.516351,"patentCount":6852,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":44.39786351230458,"pubTatorScore":2.7606369787054743,"self":"https://pharos.nih.gov/idg/api/v1/targets(4561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":658,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/properties"},"_links":{"count":1279,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/synonyms"},"_publications":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/publications"},"_namespace":null},{"id":4562,"version":2,"created":1554889819000,"modified":1554889819000,"deprecated":false,"name":"T-complex protein 11 X-linked protein 1","accession":"B4DZS4","gene":"TCP11X1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.312496128557586,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4562)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/publications"},"_namespace":null},{"id":4563,"version":2,"created":1554889819000,"modified":1554889822000,"deprecated":false,"name":"Periaxin","accession":"Q9BXM0","gene":"PRX","description":"Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6552429542744065,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":45.490245,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.12023973475436,"pubTatorScore":2.2229681199881655,"self":"https://pharos.nih.gov/idg/api/v1/targets(4563)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/publications"},"_namespace":null},{"id":4564,"version":3,"created":1554889823000,"modified":1555035666000,"deprecated":false,"name":"Twinfilin-1","accession":"Q12792","gene":"TWF1","description":"Actin-binding protein involved in motile and morphological processes. 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It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-3.096486782179718,"antibodyCount":222,"monoclonalCount":50,"pubmedCount":null,"jensenScore":1238.469333,"patentCount":36302,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.002412338710606,"pubTatorScore":2.485832377386495,"self":"https://pharos.nih.gov/idg/api/v1/targets(4565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":573,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/properties"},"_links":{"count":1266,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/publications"},"_namespace":null},{"id":4566,"version":2,"created":1554889848000,"modified":1554889850000,"deprecated":false,"name":"Proline-rich nuclear receptor coactivator 1","accession":"Q12796","gene":"PNRC1","description":"Nuclear receptor coactivator. 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Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.917828625755139,"pubTatorScore":0.07493048280725821,"self":"https://pharos.nih.gov/idg/api/v1/targets(4570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/properties"},"_links":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/publications"},"_namespace":null},{"id":4571,"version":2,"created":1554889863000,"modified":1554889864000,"deprecated":false,"name":"T-complex protein 10A homolog","accession":"Q12799","gene":"TCP10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1159273436326,"antibodyCount":66,"monoclonalCount":6,"pubmedCount":null,"jensenScore":12.592567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.357801673318038,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(4571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/properties"},"_links":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/publications"},"_namespace":null},{"id":4572,"version":2,"created":1554889864000,"modified":1554889864000,"deprecated":false,"name":"Immunoglobulin lambda constant 6","accession":"P0CF74","gene":"IGLC6","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. 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This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. 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In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6856081273965535,"antibodyCount":133,"monoclonalCount":31,"pubmedCount":null,"jensenScore":4.940335,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":17.03243658933499,"pubTatorScore":0.9615821565981814,"self":"https://pharos.nih.gov/idg/api/v1/targets(4673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/properties"},"_links":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/publications"},"_namespace":null},{"id":4674,"version":3,"created":1554891473000,"modified":1555035743000,"deprecated":false,"name":"Interleukin-36 gamma","accession":"Q9NZH8","gene":"IL36G","description":"Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. 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May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. 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Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9053460729058048,"antibodyCount":107,"monoclonalCount":4,"pubmedCount":null,"jensenScore":8.774809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.42792718170876,"pubTatorScore":0.637775529308494,"self":"https://pharos.nih.gov/idg/api/v1/targets(4676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/publications"},"_namespace":null},{"id":4677,"version":3,"created":1554891480000,"modified":1555035746000,"deprecated":false,"name":"Voltage-dependent L-type calcium channel subunit alpha-1C","accession":"Q13936","gene":"CACNA1C","description":"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. 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Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. 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May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6002466420957517,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.820262,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":25.26898597234288,"pubTatorScore":0.6872315415723759,"self":"https://pharos.nih.gov/idg/api/v1/targets(4688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/publications"},"_namespace":null},{"id":4689,"version":2,"created":1554891559000,"modified":1554891562000,"deprecated":false,"name":"Kv channel-interacting protein 1","accession":"Q9NZI2","gene":"KCNIP1","description":"Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. 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Increases the presence of KCND2 at the cell surface.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.5248735463793874,"antibodyCount":222,"monoclonalCount":111,"pubmedCount":null,"jensenScore":33.116193,"patentCount":2535,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.873291990886166,"pubTatorScore":1.4944417180699543,"self":"https://pharos.nih.gov/idg/api/v1/targets(4689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/publications"},"_namespace":null},{"id":4690,"version":3,"created":1554891562000,"modified":1555035760000,"deprecated":false,"name":"Pre-B-cell leukemia transcription factor 1","accession":"P40424","gene":"PBX1","description":"Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3064040624906137,"antibodyCount":232,"monoclonalCount":96,"pubmedCount":null,"jensenScore":200.04704,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.41577346917104,"pubTatorScore":2.0909764821049577,"self":"https://pharos.nih.gov/idg/api/v1/targets(4690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":523,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/publications"},"_namespace":null},{"id":4691,"version":3,"created":1554891567000,"modified":1555035762000,"deprecated":false,"name":"MAP/microtubule affinity-regulating kinase 3","accession":"P27448","gene":"MARK3","description":"Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.481653229865026,"antibodyCount":314,"monoclonalCount":89,"pubmedCount":null,"jensenScore":289.639078,"patentCount":4384,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.114132310393195,"pubTatorScore":2.3617901565805552,"self":"https://pharos.nih.gov/idg/api/v1/targets(4691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/publications"},"_namespace":null},{"id":4692,"version":2,"created":1554891573000,"modified":1554891576000,"deprecated":false,"name":"Grainyhead-like protein 1 homolog","accession":"Q9NZI5","gene":"GRHL1","description":"Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed:12175488).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5810353417543268,"antibodyCount":95,"monoclonalCount":2,"pubmedCount":null,"jensenScore":30.633459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.837419742241416,"pubTatorScore":1.258667663122169,"self":"https://pharos.nih.gov/idg/api/v1/targets(4692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/publications"},"_namespace":null},{"id":4693,"version":2,"created":1554891577000,"modified":1554891579000,"deprecated":false,"name":"Transcription factor CP2-like protein 1","accession":"Q9NZI6","gene":"TFCP2L1","description":"Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1070058922487274,"antibodyCount":231,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.384972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.97980990720374,"pubTatorScore":0.9526310414275215,"self":"https://pharos.nih.gov/idg/api/v1/targets(4693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/publications"},"_namespace":null},{"id":4694,"version":2,"created":1554891580000,"modified":1554891581000,"deprecated":false,"name":"Sodium/myo-inositol cotransporter","accession":"P53794","gene":"SLC5A3","description":"Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.6204287282065688,"antibodyCount":145,"monoclonalCount":20,"pubmedCount":null,"jensenScore":40.414464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.778988761014546,"pubTatorScore":1.9117874809058775,"self":"https://pharos.nih.gov/idg/api/v1/targets(4694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/properties"},"_links":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/publications"},"_namespace":null},{"id":4695,"version":2,"created":1554891581000,"modified":1554891583000,"deprecated":false,"name":"Upstream-binding protein 1","accession":"Q9NZI7","gene":"UBP1","description":"Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6964085041579047,"antibodyCount":194,"monoclonalCount":49,"pubmedCount":null,"jensenScore":47.421917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.124395602663576,"pubTatorScore":1.1372485320589412,"self":"https://pharos.nih.gov/idg/api/v1/targets(4695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/publications"},"_namespace":null},{"id":4696,"version":2,"created":1554891585000,"modified":1554891587000,"deprecated":false,"name":"Insulin-like growth factor 2 mRNA-binding protein 1","accession":"Q9NZI8","gene":"IGF2BP1","description":"RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8599667349577487,"antibodyCount":207,"monoclonalCount":3,"pubmedCount":null,"jensenScore":76.008891,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.103011634081845,"pubTatorScore":2.230665215136594,"self":"https://pharos.nih.gov/idg/api/v1/targets(4696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/synonyms"},"_publications":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/publications"},"_namespace":null},{"id":4697,"version":2,"created":1554891588000,"modified":1554891590000,"deprecated":false,"name":"Protein CASP","accession":"Q13948","gene":"CUX1","description":"May be involved in intra-Golgi retrograde transport.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4350452909445885,"antibodyCount":295,"monoclonalCount":40,"pubmedCount":null,"jensenScore":487.871765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.903472001330128,"self":"https://pharos.nih.gov/idg/api/v1/targets(4697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/properties"},"_links":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/publications"},"_namespace":null},{"id":4698,"version":3,"created":1554891591000,"modified":1554891752000,"deprecated":false,"name":"High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A","accession":"Q13946","gene":"PDE7A","description":"Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.9157419638136257,"antibodyCount":162,"monoclonalCount":5,"pubmedCount":null,"jensenScore":84.851784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.29194806764512,"pubTatorScore":1.815184115125523,"self":"https://pharos.nih.gov/idg/api/v1/targets(4698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/properties"},"_links":{"count":1355,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/publications"},"_namespace":null},{"id":4699,"version":2,"created":1554891754000,"modified":1554891754000,"deprecated":false,"name":"Immunoglobulin heavy variable 1-69-2","accession":"A0A0G2JMI3","gene":"IGHV1-69-2","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/publications"},"_namespace":null},{"id":4700,"version":3,"created":1554891754000,"modified":1555035764000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 8","accession":"Q5TAQ9","gene":"DCAF8","description":"May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7089871237906594,"antibodyCount":50,"monoclonalCount":11,"pubmedCount":null,"jensenScore":4.897912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":35.32180426407417,"pubTatorScore":0.9727977105422994,"self":"https://pharos.nih.gov/idg/api/v1/targets(4700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/properties"},"_links":{"count":1107,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/publications"},"_namespace":null},{"id":4701,"version":3,"created":1554891759000,"modified":1555035766000,"deprecated":false,"name":"L-selectin","accession":"P14151","gene":"SELL","description":"Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.4650478790419235,"antibodyCount":1166,"monoclonalCount":878,"pubmedCount":null,"jensenScore":2829.944761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.08095858817714,"pubTatorScore":3.1713356175269496,"self":"https://pharos.nih.gov/idg/api/v1/targets(4701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/properties"},"_links":{"count":1117,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/synonyms"},"_publications":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/publications"},"_namespace":null},{"id":4702,"version":2,"created":1554891765000,"modified":1554891765000,"deprecated":false,"name":"Endogenous retrovirus group K member 21 Pro protein","accession":"P63119","gene":"ERVK-21","description":"Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/publications"},"_namespace":null},{"id":4703,"version":2,"created":1554891765000,"modified":1554891767000,"deprecated":false,"name":"Prospero homeobox protein 2","accession":"Q3B8N5","gene":"PROX2","description":"Transcription regulator. 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Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. 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Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). 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Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). 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Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. 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Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). 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Required to mediate CEP290 association with microtubules.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9582452641980094,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.533334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.426197371221168,"pubTatorScore":0.9294189257142927,"self":"https://pharos.nih.gov/idg/api/v1/targets(4722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/publications"},"_namespace":null},{"id":4723,"version":2,"created":1554891862000,"modified":1554891864000,"deprecated":false,"name":"Protocadherin beta-10","accession":"Q9UN67","gene":"PCDHB10","description":"Potential calcium-dependent cell-adhesion protein. 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May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3725644979900773,"antibodyCount":83,"monoclonalCount":4,"pubmedCount":null,"jensenScore":237.978421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.29690382340693,"pubTatorScore":1.5890630153518006,"self":"https://pharos.nih.gov/idg/api/v1/targets(4727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/publications"},"_namespace":null},{"id":4728,"version":3,"created":1554891879000,"modified":1555035788000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX6","accession":"P26196","gene":"DDX6","description":"In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8148078580922502,"antibodyCount":302,"monoclonalCount":30,"pubmedCount":null,"jensenScore":65.559468,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":45.35609504916781,"pubTatorScore":1.637498085097855,"self":"https://pharos.nih.gov/idg/api/v1/targets(4728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/properties"},"_links":{"count":1148,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/publications"},"_namespace":null},{"id":4729,"version":3,"created":1554891883000,"modified":1555035790000,"deprecated":false,"name":"WW domain-containing oxidoreductase","accession":"Q9NZC7","gene":"WWOX","description":"Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.6168311729425713,"antibodyCount":251,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3311.442972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":54.8997184890683,"pubTatorScore":2.405100857204714,"self":"https://pharos.nih.gov/idg/api/v1/targets(4729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":645,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/synonyms"},"_publications":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/publications"},"_namespace":null},{"id":4730,"version":2,"created":1554891890000,"modified":1554891893000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1","accession":"Q9NZC9","gene":"SMARCAL1","description":"ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7485233622883587,"antibodyCount":133,"monoclonalCount":8,"pubmedCount":null,"jensenScore":65.061731,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.106084812385106,"pubTatorScore":1.8633511835260066,"self":"https://pharos.nih.gov/idg/api/v1/targets(4730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/publications"},"_namespace":null},{"id":4731,"version":3,"created":1554891894000,"modified":1555035792000,"deprecated":false,"name":"RNA-binding motif protein, X chromosome","accession":"P38159","gene":"RBMX","description":"RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5240151871246796,"antibodyCount":98,"monoclonalCount":3,"pubmedCount":null,"jensenScore":35.809034,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":46.30885998611814,"pubTatorScore":1.3473764677029987,"self":"https://pharos.nih.gov/idg/api/v1/targets(4731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/publications"},"_namespace":null},{"id":4732,"version":3,"created":1554891898000,"modified":1555035795000,"deprecated":false,"name":"RNA-binding protein 4","accession":"Q9BWF3","gene":"RBM4","description":"RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. 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When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3354398148722746,"antibodyCount":168,"monoclonalCount":19,"pubmedCount":null,"jensenScore":208.550448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.45225453469404,"pubTatorScore":1.8740315532355036,"self":"https://pharos.nih.gov/idg/api/v1/targets(4777)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":514,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/links"},"_synonyms":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/publications"},"_namespace":null},{"id":4778,"version":2,"created":1554892030000,"modified":1554892034000,"deprecated":false,"name":"Ubiquilin-1","accession":"Q9UMX0","gene":"UBQLN1","description":"Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. 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Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. 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The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. 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Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2594839132036413,"antibodyCount":74,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.186383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":25.88509398841457,"pubTatorScore":0.7524599486017405,"self":"https://pharos.nih.gov/idg/api/v1/targets(4864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/publications"},"_namespace":null},{"id":4865,"version":3,"created":1554892311000,"modified":1555035901000,"deprecated":false,"name":"Pre-mRNA-processing factor 19","accession":"Q9UMS4","gene":"PRPF19","description":"Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. 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'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7152370733539037,"antibodyCount":234,"monoclonalCount":29,"pubmedCount":null,"jensenScore":54.247762,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":38.697156179055064,"pubTatorScore":1.7746241174094766,"self":"https://pharos.nih.gov/idg/api/v1/targets(4865)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/properties"},"_links":{"count":1193,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/publications"},"_namespace":null},{"id":4866,"version":3,"created":1554892315000,"modified":1555035903000,"deprecated":false,"name":"Intraflagellar transport protein 27 homolog","accession":"Q9BW83","gene":"IFT27","description":"Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). 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Forms a subcomplex within the IFT complex B with IFT25 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2449573484226266,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.545002,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":37.130694336665954,"pubTatorScore":0.9927007465366534,"self":"https://pharos.nih.gov/idg/api/v1/targets(4866)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/publications"},"_namespace":null},{"id":4867,"version":3,"created":1554892319000,"modified":1555035905000,"deprecated":false,"name":"Chloride intracellular channel protein 5","accession":"Q9NZA1","gene":"CLIC5","description":"Required for normal hearing (PubMed:24781754). 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Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). 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Involved in HIV-1 p6- and p9-dependent virus release.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3580443672937186,"antibodyCount":157,"monoclonalCount":11,"pubmedCount":null,"jensenScore":24.250462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":36.87907089231076,"pubTatorScore":1.193222860283651,"self":"https://pharos.nih.gov/idg/api/v1/targets(4999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/properties"},"_links":{"count":1074,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/publications"},"_namespace":null},{"id":5000,"version":2,"created":1554893488000,"modified":1554893491000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 9","accession":"O43307","gene":"ARHGEF9","description":"Acts as guanine nucleotide exchange factor (GEF) for CDC42. 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During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. 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Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0215579804417663,"antibodyCount":235,"monoclonalCount":62,"pubmedCount":null,"jensenScore":10.871867,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.32710724678933,"pubTatorScore":0.9585486898159157,"self":"https://pharos.nih.gov/idg/api/v1/targets(5058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/publications"},"_namespace":null},{"id":5059,"version":3,"created":1554893663000,"modified":1555036033000,"deprecated":false,"name":"LIM and cysteine-rich domains protein 1","accession":"Q9NZU5","gene":"LMCD1","description":"Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. 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Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0017226535539725,"antibodyCount":67,"monoclonalCount":26,"pubmedCount":null,"jensenScore":10.931751,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.2234284162914,"pubTatorScore":0.8097146190377389,"self":"https://pharos.nih.gov/idg/api/v1/targets(5059)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/publications"},"_namespace":null},{"id":5060,"version":3,"created":1554893666000,"modified":1555036034000,"deprecated":false,"name":"Calcium-binding protein 1","accession":"Q9NZU7","gene":"CABP1","description":"Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4626712420394332,"antibodyCount":100,"monoclonalCount":8,"pubmedCount":null,"jensenScore":34.879268,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.489805885231114,"pubTatorScore":1.5685889889801956,"self":"https://pharos.nih.gov/idg/api/v1/targets(5060)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/publications"},"_namespace":null},{"id":5061,"version":2,"created":1554893670000,"modified":1554893672000,"deprecated":false,"name":"Caspase recruitment domain-containing protein 6","accession":"Q9BX69","gene":"CARD6","description":"May be involved in apoptosis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8631185834738431,"antibodyCount":239,"monoclonalCount":22,"pubmedCount":null,"jensenScore":8.434526,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.58819885928487,"pubTatorScore":0.7994029317200615,"self":"https://pharos.nih.gov/idg/api/v1/targets(5061)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/publications"},"_namespace":null},{"id":5062,"version":3,"created":1554893673000,"modified":1555036037000,"deprecated":false,"name":"Histidine triad nucleotide-binding protein 2, mitochondrial","accession":"Q9BX68","gene":"HINT2","description":"Hydrolase probably involved in steroid biosynthesis. 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Has adenosine phosphoramidase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3941596899091702,"antibodyCount":84,"monoclonalCount":24,"pubmedCount":null,"jensenScore":24.203967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":28.380999057146745,"pubTatorScore":0.920384190010849,"self":"https://pharos.nih.gov/idg/api/v1/targets(5062)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/publications"},"_namespace":null},{"id":5063,"version":2,"created":1554893676000,"modified":1554893679000,"deprecated":false,"name":"[F-actin]-monooxygenase MICAL2","accession":"O94851","gene":"MICAL2","description":"Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4764922657148974,"antibodyCount":57,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.616452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.01591435561061,"pubTatorScore":0.672977014428254,"self":"https://pharos.nih.gov/idg/api/v1/targets(5063)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/publications"},"_namespace":null},{"id":5064,"version":2,"created":1554893679000,"modified":1554893683000,"deprecated":false,"name":"Fanconi anemia group J protein","accession":"Q9BX63","gene":"BRIP1","description":"DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8187465390023196,"antibodyCount":223,"monoclonalCount":53,"pubmedCount":null,"jensenScore":78.300437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.42470307810724,"pubTatorScore":2.0474962504997256,"self":"https://pharos.nih.gov/idg/api/v1/targets(5064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":539,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/synonyms"},"_publications":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/publications"},"_namespace":null},{"id":5065,"version":2,"created":1554893684000,"modified":1554893686000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 69","accession":"Q6ZNQ3","gene":"LRRC69","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.006958345326943,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/properties"},"_links":{"count":751,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/publications"},"_namespace":null},{"id":5066,"version":3,"created":1554893687000,"modified":1555036039000,"deprecated":false,"name":"Cyclin-dependent kinase 19","accession":"Q9BWU1","gene":"CDK19","description":null,"idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.3539977159874228,"antibodyCount":154,"monoclonalCount":22,"pubmedCount":null,"jensenScore":17.997991,"patentCount":3925,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":41.6724391788971,"pubTatorScore":1.3005492044997105,"self":"https://pharos.nih.gov/idg/api/v1/targets(5066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/publications"},"_namespace":null},{"id":5067,"version":2,"created":1554893692000,"modified":1554893695000,"deprecated":false,"name":"Kanadaptin","accession":"Q9BWU0","gene":"SLC4A1AP","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.4648868019217715,"antibodyCount":86,"monoclonalCount":9,"pubmedCount":null,"jensenScore":3.431047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.02679040728838,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(5067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/publications"},"_namespace":null},{"id":5068,"version":2,"created":1554893695000,"modified":1554893697000,"deprecated":false,"name":"Dendrin","accession":"O94850","gene":"DDN","description":"Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1131259112908065,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":132.846781,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.743918802617294,"pubTatorScore":0.8940924875140192,"self":"https://pharos.nih.gov/idg/api/v1/targets(5068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/publications"},"_namespace":null},{"id":5069,"version":3,"created":1554893698000,"modified":1555036041000,"deprecated":false,"name":"Protein transport protein Sec24D","accession":"O94855","gene":"SEC24D","description":"Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). 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May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.083827986902072,"antibodyCount":66,"monoclonalCount":43,"pubmedCount":null,"jensenScore":8.632333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.162547016727785,"pubTatorScore":0.851955595960691,"self":"https://pharos.nih.gov/idg/api/v1/targets(5069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/publications"},"_namespace":null},{"id":5070,"version":3,"created":1554893703000,"modified":1555036042000,"deprecated":false,"name":"Junctional adhesion molecule C","accession":"Q9BX67","gene":"JAM3","description":"Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). 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Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). 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Positive regulator of CDC27 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6171751465581664,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.87845,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.802348899647228,"pubTatorScore":1.8851476337440434,"self":"https://pharos.nih.gov/idg/api/v1/targets(5086)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(5086)/properties"},"_links":{"count":809,"href":"https://pharos.nih.gov/idg/api/v1/targets(5086)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(5086)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(5086)/publications"},"_namespace":null},{"id":5087,"version":3,"created":1554893764000,"modified":1555036050000,"deprecated":false,"name":"Beclin 1-associated autophagy-related key regulator","accession":"Q6ZNE5","gene":"ATG14","description":"Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6338973246051018,"antibodyCount":127,"monoclonalCount":4,"pubmedCount":null,"jensenScore":38.595703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":35.20159009140493,"pubTatorScore":1.4298940887073404,"self":"https://pharos.nih.gov/idg/api/v1/targets(5087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/publications"},"_namespace":null},{"id":5088,"version":3,"created":1554893767000,"modified":1555036052000,"deprecated":false,"name":"RUN and FYVE domain-containing protein 4","accession":"Q6ZNE9","gene":"RUFY4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.155556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":17.79281835496501,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(5088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/properties"},"_links":{"count":702,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/publications"},"_namespace":null},{"id":5089,"version":2,"created":1554893769000,"modified":1554893772000,"deprecated":false,"name":"F-BAR and double SH3 domains protein 2","accession":"O94868","gene":"FCHSD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5611743842633938,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.287071,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.376264789324104,"pubTatorScore":0.66266425946456,"self":"https://pharos.nih.gov/idg/api/v1/targets(5089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/publications"},"_namespace":null},{"id":5090,"version":2,"created":1554893772000,"modified":1554893775000,"deprecated":false,"name":"Cell cycle regulator of non-homologous end joining","accession":"Q9BWK5","gene":"C7orf49","description":"Isoform 4: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:24610814, PubMed:28959974). 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Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.76454983415252,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":54.428278,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.113770713335416,"self":"https://pharos.nih.gov/idg/api/v1/targets(5090)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(5090)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(5090)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(5090)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(5090)/publications"},"_namespace":null},{"id":5091,"version":2,"created":1554893775000,"modified":1554893778000,"deprecated":false,"name":"E3 UFM1-protein ligase 1","accession":"O94874","gene":"UFL1","description":"E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2072094331412355,"antibodyCount":85,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.549016,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.318046806800005,"pubTatorScore":1.1563471907600522,"self":"https://pharos.nih.gov/idg/api/v1/targets(5091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/publications"},"_namespace":null},{"id":5092,"version":3,"created":1554893779000,"modified":1555036052000,"deprecated":false,"name":"Actin-binding LIM protein 2","accession":"Q6H8Q1","gene":"ABLIM2","description":"May act as scaffold protein. 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Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4865261618626135,"antibodyCount":82,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.56487,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.66347102180186,"pubTatorScore":1.3786970431520642,"self":"https://pharos.nih.gov/idg/api/v1/targets(5093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/properties"},"_links":{"count":1271,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/publications"},"_namespace":null},{"id":5094,"version":2,"created":1554893787000,"modified":1554893790000,"deprecated":false,"name":"Transmembrane and coiled-coil domains protein 1","accession":"O94876","gene":"TMCC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8028551283922968,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.64154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.214987167519446,"pubTatorScore":0.8372727025023002,"self":"https://pharos.nih.gov/idg/api/v1/targets(5094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/publications"},"_namespace":null},{"id":5095,"version":2,"created":1554893790000,"modified":1554893793000,"deprecated":false,"name":"Splicing factor 3B subunit 5","accession":"Q9BWJ5","gene":"SF3B5","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). 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Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.22812025866487812,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.300641,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.86254118718643,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5095)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(5095)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(5095)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(5095)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(5095)/publications"},"_namespace":null},{"id":5096,"version":2,"created":1554893794000,"modified":1554893794000,"deprecated":false,"name":"Olfactory receptor 6C3","accession":"Q9NZP0","gene":"OR6C3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-1.1794560363145394,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.825225,"patentCount":192,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.153853845747483,"pubTatorScore":0.8737725676908771,"self":"https://pharos.nih.gov/idg/api/v1/targets(5096)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(5096)/properties"},"_links":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(5096)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(5096)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5096)/publications"},"_namespace":null},{"id":5097,"version":2,"created":1554893794000,"modified":1554893797000,"deprecated":false,"name":"Alcohol dehydrogenase class 4 mu/sigma chain","accession":"P40394","gene":"ADH7","description":"Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol 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Plays a role in dendrite formation by melanocytes (PubMed:23999003).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5550142113993815,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":357.21247,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.603720942652075,"pubTatorScore":1.4472410977279473,"self":"https://pharos.nih.gov/idg/api/v1/targets(5160)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(5160)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(5160)/links"},"_synonyms":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(5160)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(5160)/publications"},"_namespace":null},{"id":5161,"version":2,"created":1554893988000,"modified":1554893990000,"deprecated":false,"name":"BRD4-interacting chromatin-remodeling complex-associated protein","accession":"Q9NZM4","gene":"BICRA","description":"May play a role in BRD4-mediated gene transcription.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3477052122321515,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.585087,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.5888494104217972,"self":"https://pharos.nih.gov/idg/api/v1/targets(5161)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(5161)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(5161)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(5161)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(5161)/publications"},"_namespace":null},{"id":5162,"version":3,"created":1554893991000,"modified":1555036100000,"deprecated":false,"name":"Sideroflexin-3","accession":"Q9BWM7","gene":"SFXN3","description":"Potential iron transporter.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5006023556359543,"antibodyCount":107,"monoclonalCount":10,"pubmedCount":null,"jensenScore":3.380952,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.41857807504611,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(5162)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(5162)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(5162)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(5162)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(5162)/publications"},"_namespace":null},{"id":5163,"version":3,"created":1554893994000,"modified":1555036103000,"deprecated":false,"name":"Ribosome biogenesis protein NOP53","accession":"Q9NZM5","gene":"NOP53","description":"Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). 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May protect against inflammation-associated gastric adenocarcinomas (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.006635819862815,"antibodyCount":235,"monoclonalCount":73,"pubmedCount":null,"jensenScore":3.505739,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":19.272837003713462,"pubTatorScore":0.9151987361722592,"self":"https://pharos.nih.gov/idg/api/v1/targets(5168)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/publications"},"_namespace":null},{"id":5169,"version":3,"created":1554894012000,"modified":1555036109000,"deprecated":false,"name":"Rho GTPase-activating protein 26","accession":"Q9UNA1","gene":"ARHGAP26","description":"GTPase-activating protein for RHOA and CDC42.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7133636968188473,"antibodyCount":219,"monoclonalCount":6,"pubmedCount":null,"jensenScore":51.869935,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":41.32284786762476,"pubTatorScore":2.5224965035052187,"self":"https://pharos.nih.gov/idg/api/v1/targets(5169)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/publications"},"_namespace":null},{"id":5170,"version":3,"created":1554894016000,"modified":1554894090000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 5","accession":"Q9UNA0","gene":"ADAMTS5","description":"Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.2625107702356306,"antibodyCount":371,"monoclonalCount":6,"pubmedCount":null,"jensenScore":168.435894,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.911857993285324,"pubTatorScore":2.0876664422874893,"self":"https://pharos.nih.gov/idg/api/v1/targets(5170)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/properties"},"_links":{"count":1171,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/publications"},"_namespace":null},{"id":5171,"version":2,"created":1554894092000,"modified":1554894095000,"deprecated":false,"name":"Interleukin-1 receptor accessory protein-like 1","accession":"Q9NZN1","gene":"IL1RAPL1","description":"May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8176955045504732,"antibodyCount":132,"monoclonalCount":82,"pubmedCount":null,"jensenScore":63.928496,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.05943053816925,"pubTatorScore":1.644171086087882,"self":"https://pharos.nih.gov/idg/api/v1/targets(5171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/publications"},"_namespace":null},{"id":5172,"version":2,"created":1554894095000,"modified":1554894099000,"deprecated":false,"name":"DNA polymerase iota","accession":"Q9UNA4","gene":"POLI","description":"Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.2400754309886093,"antibodyCount":333,"monoclonalCount":147,"pubmedCount":null,"jensenScore":1701.877752,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.754109382814946,"pubTatorScore":2.7761418746432684,"self":"https://pharos.nih.gov/idg/api/v1/targets(5172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/links"},"_synonyms":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/publications"},"_namespace":null},{"id":5173,"version":3,"created":1554894100000,"modified":1555036111000,"deprecated":false,"name":"EH domain-containing protein 3","accession":"Q9NZN3","gene":"EHD3","description":"ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6966106057389705,"antibodyCount":89,"monoclonalCount":26,"pubmedCount":null,"jensenScore":55.775501,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.58161730507622,"pubTatorScore":1.9698717242169155,"self":"https://pharos.nih.gov/idg/api/v1/targets(5173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/publications"},"_namespace":null},{"id":5174,"version":3,"created":1554894104000,"modified":1555036112000,"deprecated":false,"name":"EH domain-containing protein 2","accession":"Q9NZN4","gene":"EHD2","description":"ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). 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Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4997228977553096,"antibodyCount":144,"monoclonalCount":54,"pubmedCount":null,"jensenScore":32.196997,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.730140699427345,"pubTatorScore":2.696469937089102,"self":"https://pharos.nih.gov/idg/api/v1/targets(5174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/publications"},"_namespace":null},{"id":5175,"version":2,"created":1554894107000,"modified":1554894111000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 12","accession":"Q9NZN5","gene":"ARHGEF12","description":"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). 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Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. 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The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. 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Plays a role in the sensory perception of pain caused by pressure (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.6684186524360067,"antibodyCount":90,"monoclonalCount":0,"pubmedCount":null,"jensenScore":40.618052,"patentCount":3119,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.126718082436504,"pubTatorScore":1.4212044719570096,"self":"https://pharos.nih.gov/idg/api/v1/targets(5227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(5227)/properties"},"_links":{"count":678,"href":"https://pharos.nih.gov/idg/api/v1/targets(5227)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(5227)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(5227)/publications"},"_namespace":null},{"id":5228,"version":2,"created":1554894325000,"modified":1554894327000,"deprecated":false,"name":"Serpin E3","accession":"A8MV23","gene":"SERPINE3","description":"Probable serine protease inhibitor.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.918201350939631,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(5228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(5228)/properties"},"_links":{"count":690,"href":"https://pharos.nih.gov/idg/api/v1/targets(5228)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(5228)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5228)/publications"},"_namespace":null},{"id":5229,"version":2,"created":1554894327000,"modified":1554894330000,"deprecated":false,"name":"Nucleolar GTP-binding protein 2","accession":"Q13823","gene":"GNL2","description":"GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.633350708251335,"antibodyCount":119,"monoclonalCount":5,"pubmedCount":null,"jensenScore":44.24764,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.7886709717741,"pubTatorScore":1.37171272638948,"self":"https://pharos.nih.gov/idg/api/v1/targets(5229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(5229)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(5229)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(5229)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5229)/publications"},"_namespace":null},{"id":5230,"version":3,"created":1554894330000,"modified":1554894373000,"deprecated":false,"name":"Ectonucleotide pyrophosphatase/phosphodiesterase family member 2","accession":"Q13822","gene":"ENPP2","description":"Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. 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Tumor cell motility-stimulating factor.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.6292057370124957,"antibodyCount":377,"monoclonalCount":5,"pubmedCount":null,"jensenScore":463.155038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.591189892052775,"pubTatorScore":2.57869034140907,"self":"https://pharos.nih.gov/idg/api/v1/targets(5230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":525,"href":"https://pharos.nih.gov/idg/api/v1/targets(5230)/properties"},"_links":{"count":1299,"href":"https://pharos.nih.gov/idg/api/v1/targets(5230)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(5230)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(5230)/publications"},"_namespace":null},{"id":5231,"version":2,"created":1554894375000,"modified":1554894376000,"deprecated":false,"name":"Uncharacterized protein C17orf98","accession":"A8MV24","gene":"C17orf98","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(5231)/properties"},"_links":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(5231)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(5231)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(5231)/publications"},"_namespace":null},{"id":5232,"version":3,"created":1554894376000,"modified":1555036148000,"deprecated":false,"name":"Histone acetyltransferase KAT6B","accession":"Q8WYB5","gene":"KAT6B","description":"Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. 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Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0056947278890256,"antibodyCount":99,"monoclonalCount":13,"pubmedCount":null,"jensenScore":102.494842,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.48111699841431,"pubTatorScore":1.8253829263647336,"self":"https://pharos.nih.gov/idg/api/v1/targets(5233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(5233)/properties"},"_links":{"count":1068,"href":"https://pharos.nih.gov/idg/api/v1/targets(5233)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(5233)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(5233)/publications"},"_namespace":null},{"id":5234,"version":3,"created":1554894386000,"modified":1555036149000,"deprecated":false,"name":"BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2","accession":"Q13829","gene":"TNFAIP1","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.312149583674549,"antibodyCount":197,"monoclonalCount":3,"pubmedCount":null,"jensenScore":21.568592,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.8152323124748,"pubTatorScore":1.3069009464609531,"self":"https://pharos.nih.gov/idg/api/v1/targets(5234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(5234)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(5234)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(5234)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(5234)/publications"},"_namespace":null},{"id":5235,"version":2,"created":1554894389000,"modified":1554894391000,"deprecated":false,"name":"Prostate tumor-overexpressed gene 1 protein","accession":"Q86YD1","gene":"PTOV1","description":"May activate transcription. Required for nuclear translocation of FLOT1. 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May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.7169137097662435,"antibodyCount":214,"monoclonalCount":35,"pubmedCount":null,"jensenScore":609.594295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.360404757976855,"pubTatorScore":2.4853519643628177,"self":"https://pharos.nih.gov/idg/api/v1/targets(5237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/synonyms"},"_publications":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/publications"},"_namespace":null},{"id":5238,"version":2,"created":1554894404000,"modified":1554894407000,"deprecated":false,"name":"TP53-target gene 3 protein","accession":"Q9ULZ0","gene":"TP53TG3B","description":"May play a significant role in p53/TP53-mediating signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.546781442977668,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(5238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/links"},"_synonyms":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/publications"},"_namespace":null},{"id":5239,"version":3,"created":1554894407000,"modified":1555036154000,"deprecated":false,"name":"Protein FAM90A1","accession":"Q86YD7","gene":"FAM90A1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":21.259142963268093,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/properties"},"_links":{"count":715,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/publications"},"_namespace":null},{"id":5240,"version":3,"created":1554894409000,"modified":1555036155000,"deprecated":false,"name":"Apoptosis-associated speck-like protein containing a CARD","accession":"Q9ULZ3","gene":"PYCARD","description":"Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating MB21D1 in presence of cytoplasmic double-stranded DNA (PubMed:28314590).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.867437434852167,"antibodyCount":477,"monoclonalCount":75,"pubmedCount":null,"jensenScore":55.85018,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.81590342721578,"pubTatorScore":2.817654279774482,"self":"https://pharos.nih.gov/idg/api/v1/targets(5240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":564,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/properties"},"_links":{"count":1233,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/publications"},"_namespace":null},{"id":5241,"version":2,"created":1554894415000,"modified":1554894417000,"deprecated":false,"name":"Low-density lipoprotein receptor class A domain-containing protein 3","accession":"Q86YD5","gene":"LDLRAD3","description":"May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3357921033708414,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.34113,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.804706514122163,"pubTatorScore":-0.1760916933503803,"self":"https://pharos.nih.gov/idg/api/v1/targets(5241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/publications"},"_namespace":null},{"id":5242,"version":2,"created":1554894418000,"modified":1554894421000,"deprecated":false,"name":"Matrix metalloproteinase-17","accession":"Q9ULZ9","gene":"MMP17","description":"Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.4082348510901432,"antibodyCount":217,"monoclonalCount":23,"pubmedCount":null,"jensenScore":27.231643,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.899791006654425,"pubTatorScore":1.4297023736315777,"self":"https://pharos.nih.gov/idg/api/v1/targets(5242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/publications"},"_namespace":null},{"id":5243,"version":3,"created":1554894422000,"modified":1555036159000,"deprecated":false,"name":"Transmembrane protein 25","accession":"Q86YD3","gene":"TMEM25","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2369124994584635,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.401338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":27.605170655899876,"pubTatorScore":0.4602910598139417,"self":"https://pharos.nih.gov/idg/api/v1/targets(5243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/publications"},"_namespace":null},{"id":5244,"version":2,"created":1554894425000,"modified":1554894427000,"deprecated":false,"name":"Polyadenylate-binding protein-interacting protein 2B","accession":"Q9ULR5","gene":"PAIP2B","description":"Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.06219385920640945,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.120132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.26988206115168,"pubTatorScore":0.2716202225045699,"self":"https://pharos.nih.gov/idg/api/v1/targets(5244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/publications"},"_namespace":null},{"id":5245,"version":2,"created":1554894428000,"modified":1554894431000,"deprecated":false,"name":"Protein phosphatase 1H","accession":"Q9ULR3","gene":"PPM1H","description":"Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9607424930417306,"antibodyCount":113,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.718903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.14364960843379,"pubTatorScore":0.9387459696850307,"self":"https://pharos.nih.gov/idg/api/v1/targets(5245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/publications"},"_namespace":null},{"id":5246,"version":2,"created":1554894431000,"modified":1554894434000,"deprecated":false,"name":"Plakophilin-1","accession":"Q13835","gene":"PKP1","description":"Seems to play a role in junctional plaques. 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Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.596649518134188,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":40.18907,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.878019214028242,"pubTatorScore":0.9251400933354534,"self":"https://pharos.nih.gov/idg/api/v1/targets(5248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/publications"},"_namespace":null},{"id":5249,"version":2,"created":1554894439000,"modified":1554894439000,"deprecated":false,"name":"Putative mucosal pentraxin homolog","accession":"A8MV57","gene":"MPTX1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.5379436216774398,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/publications"},"_namespace":null},{"id":5250,"version":2,"created":1554894439000,"modified":1554894442000,"deprecated":false,"name":"Endoribonuclease ZC3H12A","accession":"Q5D1E8","gene":"ZC3H12A","description":"(Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.31479860064854,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/properties"},"_links":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/publications"},"_namespace":null},{"id":5252,"version":2,"created":1554894444000,"modified":1554894447000,"deprecated":false,"name":"Spliceosome RNA helicase DDX39B","accession":"Q13838","gene":"DDX39B","description":"Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. 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Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4338646744341172,"antibodyCount":194,"monoclonalCount":11,"pubmedCount":null,"jensenScore":23.936756,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":36.85666312249471,"pubTatorScore":1.3826161897485756,"self":"https://pharos.nih.gov/idg/api/v1/targets(5343)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(5343)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(5343)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(5343)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(5343)/publications"},"_namespace":null},{"id":5344,"version":2,"created":1554894969000,"modified":1554894972000,"deprecated":false,"name":"Formin-binding protein 1","accession":"Q96RU3","gene":"FNBP1","description":"May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.124617593269131,"antibodyCount":129,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.253415,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.21526136983523,"pubTatorScore":1.2133439247317614,"self":"https://pharos.nih.gov/idg/api/v1/targets(5344)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(5344)/properties"},"_links":{"count":1082,"href":"https://pharos.nih.gov/idg/api/v1/targets(5344)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(5344)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(5344)/publications"},"_namespace":null},{"id":5345,"version":2,"created":1554894973000,"modified":1554894977000,"deprecated":false,"name":"SET-binding protein","accession":"Q9Y6X0","gene":"SETBP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.468046173457157,"antibodyCount":98,"monoclonalCount":3,"pubmedCount":null,"jensenScore":281.578705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.98569291342215,"pubTatorScore":2.3671217713268313,"self":"https://pharos.nih.gov/idg/api/v1/targets(5345)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(5345)/properties"},"_links":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(5345)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(5345)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(5345)/publications"},"_namespace":null},{"id":5346,"version":2,"created":1554894978000,"modified":1554894993000,"deprecated":false,"name":"Cytosol aminopeptidase","accession":"P28838","gene":"LAP3","description":"Presumably involved in the processing and regular turnover of intracellular proteins. 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Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. 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The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). 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Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.063933851621201,"antibodyCount":694,"monoclonalCount":251,"pubmedCount":null,"jensenScore":1238.432059,"patentCount":42088,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":53.60095505024111,"pubTatorScore":2.7346591353797796,"self":"https://pharos.nih.gov/idg/api/v1/targets(5411)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/properties"},"_links":{"count":1439,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/synonyms"},"_publications":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/publications"},"_namespace":null},{"id":5412,"version":4,"created":1554896347000,"modified":1555036281000,"deprecated":false,"name":"Cyclin-dependent kinase 6","accession":"Q00534","gene":"CDK6","description":"Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. 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Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. 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Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9285665412904466,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.046614,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.10962535868346,"pubTatorScore":0.6690067189165023,"self":"https://pharos.nih.gov/idg/api/v1/targets(5432)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(5432)/properties"},"_links":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(5432)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(5432)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(5432)/publications"},"_namespace":null},{"id":5433,"version":2,"created":1554896464000,"modified":1554896465000,"deprecated":false,"name":"Histatin-3","accession":"P15516","gene":"HTN3","description":"Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6726471968731644,"antibodyCount":9,"monoclonalCount":8,"pubmedCount":null,"jensenScore":435.808476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.937669024284798,"pubTatorScore":1.3341185113263763,"self":"https://pharos.nih.gov/idg/api/v1/targets(5433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(5433)/properties"},"_links":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(5433)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(5433)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(5433)/publications"},"_namespace":null},{"id":5434,"version":2,"created":1554896465000,"modified":1554896466000,"deprecated":false,"name":"Histatin-1","accession":"P15515","gene":"HTN1","description":"Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). 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PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6271936391286748,"antibodyCount":79,"monoclonalCount":2,"pubmedCount":null,"jensenScore":42.796444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.356718060320176,"pubTatorScore":1.6095380539925876,"self":"https://pharos.nih.gov/idg/api/v1/targets(5437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(5437)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(5437)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(5437)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(5437)/publications"},"_namespace":null},{"id":5438,"version":2,"created":1554896477000,"modified":1554896479000,"deprecated":false,"name":"DnaJ homolog subfamily C member 9","accession":"Q8WXX5","gene":"DNAJC9","description":"May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7318189243266296,"antibodyCount":94,"monoclonalCount":4,"pubmedCount":null,"jensenScore":5.579366,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.24360875579086,"pubTatorScore":0.6989700043360189,"self":"https://pharos.nih.gov/idg/api/v1/targets(5438)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(5438)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(5438)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(5438)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5438)/publications"},"_namespace":null},{"id":5439,"version":2,"created":1554896480000,"modified":1554896485000,"deprecated":false,"name":"Calcium/calmodulin-dependent protein kinase kinase 2","accession":"Q96RR4","gene":"CAMKK2","description":"Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.098409830032055,"antibodyCount":257,"monoclonalCount":35,"pubmedCount":null,"jensenScore":125.4567,"patentCount":3875,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.2870501584499,"pubTatorScore":1.9062347599301235,"self":"https://pharos.nih.gov/idg/api/v1/targets(5439)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(5439)/properties"},"_links":{"count":1203,"href":"https://pharos.nih.gov/idg/api/v1/targets(5439)/links"},"_synonyms":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(5439)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(5439)/publications"},"_namespace":null},{"id":5440,"version":3,"created":1554896486000,"modified":1555036295000,"deprecated":false,"name":"Cerebellar degeneration-related protein 2","accession":"Q01850","gene":"CDR2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.677778637202043,"antibodyCount":276,"monoclonalCount":96,"pubmedCount":null,"jensenScore":450.305826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":34.202324276173286,"pubTatorScore":2.330285706596487,"self":"https://pharos.nih.gov/idg/api/v1/targets(5440)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(5440)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(5440)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(5440)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(5440)/publications"},"_namespace":null},{"id":5441,"version":2,"created":1554896489000,"modified":1554896492000,"deprecated":false,"name":"Dynein heavy chain 7, axonemal","accession":"Q8WXX0","gene":"DNAH7","description":"Force generating protein of respiratory cilia. 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Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.160053343474253,"antibodyCount":154,"monoclonalCount":19,"pubmedCount":null,"jensenScore":165.402725,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.101233691249746,"pubTatorScore":2.2310333208571764,"self":"https://pharos.nih.gov/idg/api/v1/targets(5478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":564,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/properties"},"_links":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/synonyms"},"_publications":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/publications"},"_namespace":null},{"id":5479,"version":3,"created":1554896705000,"modified":1555036324000,"deprecated":false,"name":"Catenin alpha-2","accession":"P26232","gene":"CTNNA2","description":"May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. 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L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.0783753703735497,"antibodyCount":166,"monoclonalCount":41,"pubmedCount":null,"jensenScore":10.742986,"patentCount":2951,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.96646158536175,"pubTatorScore":1.0098586097140587,"self":"https://pharos.nih.gov/idg/api/v1/targets(5485)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(5485)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(5485)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(5485)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(5485)/publications"},"_namespace":null},{"id":5486,"version":2,"created":1554896723000,"modified":1554896725000,"deprecated":false,"name":"Homeobox protein Hox-A3","accession":"O43365","gene":"HOXA3","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6569023186821583,"antibodyCount":164,"monoclonalCount":11,"pubmedCount":null,"jensenScore":45.353051,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.321178675997082,"pubTatorScore":1.2007428136225076,"self":"https://pharos.nih.gov/idg/api/v1/targets(5486)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(5486)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(5486)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(5486)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(5486)/publications"},"_namespace":null},{"id":5487,"version":3,"created":1554896726000,"modified":1555036331000,"deprecated":false,"name":"RING finger protein 150","accession":"Q9ULK6","gene":"RNF150","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.12493873552256378,"antibodyCount":119,"monoclonalCount":6,"pubmedCount":null,"jensenScore":0.7,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.781463558652373,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(5487)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(5487)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(5487)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(5487)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(5487)/publications"},"_namespace":null},{"id":5488,"version":3,"created":1554896729000,"modified":1555036332000,"deprecated":false,"name":"Vang-like protein 2","accession":"Q9ULK5","gene":"VANGL2","description":"Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2932242018434468,"antibodyCount":158,"monoclonalCount":2,"pubmedCount":null,"jensenScore":199.602556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.70151079958259,"pubTatorScore":1.6795131753162846,"self":"https://pharos.nih.gov/idg/api/v1/targets(5488)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(5488)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(5488)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(5488)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(5488)/publications"},"_namespace":null},{"id":5489,"version":2,"created":1554896732000,"modified":1554896735000,"deprecated":false,"name":"Mediator of RNA polymerase II transcription subunit 23","accession":"Q9ULK4","gene":"MED23","description":"Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4982257682401894,"antibodyCount":161,"monoclonalCount":21,"pubmedCount":null,"jensenScore":34.202876,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.49477687867484,"pubTatorScore":1.3945501914574767,"self":"https://pharos.nih.gov/idg/api/v1/targets(5489)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(5489)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(5489)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(5489)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(5489)/publications"},"_namespace":null},{"id":5490,"version":2,"created":1554896736000,"modified":1554896750000,"deprecated":false,"name":"Solute carrier family 5 member 4","accession":"Q9NY91","gene":"SLC5A4","description":"Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068). 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Also potently activated by imino sugars such as deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.804620706100738,"antibodyCount":70,"monoclonalCount":2,"pubmedCount":null,"jensenScore":596.685354,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.96508422508838,"pubTatorScore":1.3325914662151899,"self":"https://pharos.nih.gov/idg/api/v1/targets(5490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(5490)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(5490)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(5490)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(5490)/publications"},"_namespace":null},{"id":5491,"version":2,"created":1554896751000,"modified":1554896753000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX56","accession":"Q9NY93","gene":"DDX56","description":"May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. 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Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.1578954841078475,"antibodyCount":134,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.794196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.840033238425566,"pubTatorScore":1.3098484519816325,"self":"https://pharos.nih.gov/idg/api/v1/targets(5564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/publications"},"_namespace":null},{"id":5565,"version":2,"created":1554897011000,"modified":1554897013000,"deprecated":false,"name":"Pyridoxal phosphate homeostasis protein","accession":"O94903","gene":"PLPBP","description":"Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.230124407524999,"antibodyCount":197,"monoclonalCount":92,"pubmedCount":null,"jensenScore":16.420455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.5642714699198773,"self":"https://pharos.nih.gov/idg/api/v1/targets(5565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/publications"},"_namespace":null},{"id":5566,"version":3,"created":1554897014000,"modified":1555036379000,"deprecated":false,"name":"Spermatogenesis-associated protein 5-like protein 1","accession":"Q9BVQ7","gene":"SPATA5L1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":82,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.819444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":28.61606601745547,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(5566)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/publications"},"_namespace":null},{"id":5567,"version":2,"created":1554897017000,"modified":1554897020000,"deprecated":false,"name":"Nuclear pore complex protein Nup85","accession":"Q9BW27","gene":"NUP85","description":"Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). 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Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.6933712771356841,"antibodyCount":76,"monoclonalCount":30,"pubmedCount":null,"jensenScore":53.764025,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.43560744670763,"pubTatorScore":1.7110869428633917,"self":"https://pharos.nih.gov/idg/api/v1/targets(5713)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(5713)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(5713)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(5713)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(5713)/publications"},"_namespace":null},{"id":5714,"version":2,"created":1554897758000,"modified":1554897762000,"deprecated":false,"name":"Gamma-secretase subunit PEN-2","accession":"Q9NZ42","gene":"PSENEN","description":"Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.847610739751764,"antibodyCount":204,"monoclonalCount":17,"pubmedCount":null,"jensenScore":677.277089,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.067784999358025,"pubTatorScore":2.2094883046106553,"self":"https://pharos.nih.gov/idg/api/v1/targets(5714)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":453,"href":"https://pharos.nih.gov/idg/api/v1/targets(5714)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(5714)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(5714)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(5714)/publications"},"_namespace":null},{"id":5715,"version":3,"created":1554897763000,"modified":1555036450000,"deprecated":false,"name":"Vesicle transport protein USE1","accession":"Q9NZ43","gene":"USE1","description":"SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6336816596358608,"antibodyCount":166,"monoclonalCount":2,"pubmedCount":null,"jensenScore":401.23049,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":35.20034633903833,"pubTatorScore":2.213886516955631,"self":"https://pharos.nih.gov/idg/api/v1/targets(5715)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(5715)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(5715)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(5715)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(5715)/publications"},"_namespace":null},{"id":5716,"version":3,"created":1554897767000,"modified":1555036451000,"deprecated":false,"name":"CDGSH iron-sulfur domain-containing protein 1","accession":"Q9NZ45","gene":"CISD1","description":"Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). 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neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0311839865996761,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.38693,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.14023817920249,"pubTatorScore":0.7203890464508661,"self":"https://pharos.nih.gov/idg/api/v1/targets(5723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(5723)/properties"},"_links":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(5723)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(5723)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5723)/publications"},"_namespace":null},{"id":5724,"version":2,"created":1554897790000,"modified":1554897793000,"deprecated":false,"name":"Protein atonal homolog 8","accession":"Q96SQ7","gene":"ATOH8","description":"Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.9655925965652159,"antibodyCount":111,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.265995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.988390385076784,"pubTatorScore":0.8550417145361918,"self":"https://pharos.nih.gov/idg/api/v1/targets(5724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/publications"},"_namespace":null},{"id":5725,"version":2,"created":1554897794000,"modified":1554897798000,"deprecated":false,"name":"E3 ubiquitin-protein ligase TRIM37","accession":"O94972","gene":"TRIM37","description":"E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.258919344334969,"antibodyCount":177,"monoclonalCount":12,"pubmedCount":null,"jensenScore":1754.811674,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.773499572813485,"pubTatorScore":1.7144095938423904,"self":"https://pharos.nih.gov/idg/api/v1/targets(5725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/publications"},"_namespace":null},{"id":5726,"version":3,"created":1554897798000,"modified":1555036457000,"deprecated":false,"name":"AP-2 complex subunit alpha-2","accession":"O94973","gene":"AP2A2","description":"Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. 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During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. 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Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). 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May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.90493182131553,"antibodyCount":237,"monoclonalCount":15,"pubmedCount":null,"jensenScore":83.682297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.11384125107434,"pubTatorScore":1.3104108122667348,"self":"https://pharos.nih.gov/idg/api/v1/targets(5832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(5832)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(5832)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(5832)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(5832)/publications"},"_namespace":null},{"id":5833,"version":2,"created":1554898144000,"modified":1554898144000,"deprecated":false,"name":"Putative uncharacterized protein C7orf71","accession":"A4D174","gene":"C7orf71","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5833)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(5833)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(5833)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5833)/publications"},"_namespace":null},{"id":5834,"version":2,"created":1554898144000,"modified":1554898146000,"deprecated":false,"name":"Uncharacterized protein C21orf62","accession":"Q9NYP8","gene":"C21orf62","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":62,"monoclonalCount":10,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6843715068911933,"self":"https://pharos.nih.gov/idg/api/v1/targets(5834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(5834)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(5834)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(5834)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(5834)/publications"},"_namespace":null},{"id":5835,"version":3,"created":1554898146000,"modified":1555036534000,"deprecated":false,"name":"Protein Mis18-alpha","accession":"Q9NYP9","gene":"MIS18A","description":"Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1401714649839896,"antibodyCount":47,"monoclonalCount":1,"pubmedCount":null,"jensenScore":104.536819,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":27.220829204168762,"pubTatorScore":1.3528253962506491,"self":"https://pharos.nih.gov/idg/api/v1/targets(5835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(5835)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(5835)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(5835)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(5835)/publications"},"_namespace":null},{"id":5836,"version":2,"created":1554898150000,"modified":1554898151000,"deprecated":false,"name":"Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase","accession":"Q6ZMB0","gene":"B3GNT6","description":"Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. 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Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). 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Has also an activity of delipidating enzyme for the PE-conjugated 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Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.6707506401633156,"antibodyCount":25,"monoclonalCount":6,"pubmedCount":null,"jensenScore":458.136118,"patentCount":7814,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.11440765202426,"pubTatorScore":2.059062793450173,"self":"https://pharos.nih.gov/idg/api/v1/targets(5938)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/publications"},"_namespace":null},{"id":5939,"version":3,"created":1554898448000,"modified":1555036585000,"deprecated":false,"name":"Blood vessel epicardial substance","accession":"Q8NE79","gene":"BVES","description":"Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. 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GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). 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In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. 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Has low GTPase activity (PubMed:27920125, PubMed:28114303).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.109087952777891,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":104.073477,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":45.55906996693494,"pubTatorScore":1.7816972327275116,"self":"https://pharos.nih.gov/idg/api/v1/targets(6067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(6067)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(6067)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(6067)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(6067)/publications"},"_namespace":null},{"id":6068,"version":2,"created":1554899089000,"modified":1554899092000,"deprecated":false,"name":"Choline transporter-like protein 2","accession":"Q8IWA5","gene":"SLC44A2","description":"Isoform 1, but not isoform 3, exhibits some choline transporter activity.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.624744723327297,"antibodyCount":92,"monoclonalCount":42,"pubmedCount":null,"jensenScore":40.316112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.104954221255014,"pubTatorScore":1.5933256281163657,"self":"https://pharos.nih.gov/idg/api/v1/targets(6068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(6068)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(6068)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(6068)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(6068)/publications"},"_namespace":null},{"id":6069,"version":3,"created":1554899093000,"modified":1555036644000,"deprecated":false,"name":"Coiled-coil domain-containing protein 60","accession":"Q8IWA6","gene":"CCDC60","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":62,"monoclonalCount":4,"pubmedCount":null,"jensenScore":1.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":16.717435159009423,"pubTatorScore":0.21559976257461566,"self":"https://pharos.nih.gov/idg/api/v1/targets(6069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(6069)/properties"},"_links":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(6069)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(6069)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(6069)/publications"},"_namespace":null},{"id":6070,"version":3,"created":1554899095000,"modified":1555036645000,"deprecated":false,"name":"Beta-arrestin-1","accession":"P49407","gene":"ARRB1","description":"Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. 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Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. 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Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. 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Does not have ribonuclease activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6532125181182885,"antibodyCount":18,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":12.679832231923735,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(6075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(6075)/properties"},"_links":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(6075)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(6075)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(6075)/publications"},"_namespace":null},{"id":6076,"version":2,"created":1554899117000,"modified":1554899118000,"deprecated":false,"name":"Transmembrane protein 270","accession":"Q6UE05","gene":"TMEM270","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5576408514059205,"antibodyCount":17,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.196923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.24303772296555518,"self":"https://pharos.nih.gov/idg/api/v1/targets(6076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(6076)/properties"},"_links":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(6076)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(6076)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(6076)/publications"},"_namespace":null},{"id":6077,"version":3,"created":1554899118000,"modified":1555036652000,"deprecated":false,"name":"Galectin-3-binding protein","accession":"Q08380","gene":"LGALS3BP","description":"Promotes integrin-mediated cell adhesion. 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May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.465973893943865,"antibodyCount":397,"monoclonalCount":227,"pubmedCount":null,"jensenScore":2968.776432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":31.407170062589422,"pubTatorScore":3.2544595164743693,"self":"https://pharos.nih.gov/idg/api/v1/targets(6112)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/synonyms"},"_publications":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/publications"},"_namespace":null},{"id":6113,"version":3,"created":1554899925000,"modified":1555036698000,"deprecated":false,"name":"60S ribosomal protein L18","accession":"Q07020","gene":"RPL18","description":"Component of the large ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4598366401952372,"antibodyCount":149,"monoclonalCount":10,"pubmedCount":null,"jensenScore":25.754147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":85,"knowledgeAvailability":40.50935474370922,"pubTatorScore":1.4066160816639504,"self":"https://pharos.nih.gov/idg/api/v1/targets(6113)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/publications"},"_namespace":null},{"id":6114,"version":2,"created":1554899930000,"modified":1554899933000,"deprecated":false,"name":"Complement component 1 Q subcomponent-binding protein, mitochondrial","accession":"Q07021","gene":"C1QBP","description":"Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. 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By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. Involved in replication of Rubella virus. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppresion of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5504629788711766,"antibodyCount":353,"monoclonalCount":119,"pubmedCount":null,"jensenScore":348.622396,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.83924157128223,"pubTatorScore":2.2760334222678584,"self":"https://pharos.nih.gov/idg/api/v1/targets(6114)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":580,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/properties"},"_links":{"count":1201,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/publications"},"_namespace":null},{"id":6115,"version":3,"created":1554899934000,"modified":1555036701000,"deprecated":false,"name":"Histone H3-like centromeric protein A","accession":"P49450","gene":"CENPA","description":"Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7332228371185114,"antibodyCount":386,"monoclonalCount":104,"pubmedCount":null,"jensenScore":566.969484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.03837313306772,"pubTatorScore":2.514625104641919,"self":"https://pharos.nih.gov/idg/api/v1/targets(6115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/publications"},"_namespace":null},{"id":6116,"version":2,"created":1554899939000,"modified":1554899943000,"deprecated":false,"name":"Centromere protein F","accession":"P49454","gene":"CENPF","description":"Required for kinetochore function and chromosome segregation in mitosis. 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Involved in dendritic cell regulation of T-cell immunity against chlamydia.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.029393275809391,"antibodyCount":186,"monoclonalCount":33,"pubmedCount":null,"jensenScore":109.085448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.805612529294685,"pubTatorScore":1.9749344059562497,"self":"https://pharos.nih.gov/idg/api/v1/targets(6116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/publications"},"_namespace":null},{"id":6117,"version":2,"created":1554899944000,"modified":1554899948000,"deprecated":false,"name":"Sodium-dependent phosphate transporter 2","accession":"Q08357","gene":"SLC20A2","description":"Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) 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Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation (PubMed:15905402). 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Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.2288823402843336,"antibodyCount":272,"monoclonalCount":5,"pubmedCount":null,"jensenScore":174.188437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.82205498045045,"pubTatorScore":1.8326146377692631,"self":"https://pharos.nih.gov/idg/api/v1/targets(6230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/publications"},"_namespace":null},{"id":6231,"version":3,"created":1554901135000,"modified":1555036783000,"deprecated":false,"name":"Period circadian protein homolog 2","accession":"O15055","gene":"PER2","description":"Transcriptional repressor which forms a core component of the circadian clock. 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The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. 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FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.544999736089638,"antibodyCount":369,"monoclonalCount":72,"pubmedCount":null,"jensenScore":414.87495,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.857569621404767,"pubTatorScore":2.5859520919690984,"self":"https://pharos.nih.gov/idg/api/v1/targets(6232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/properties"},"_links":{"count":666,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/synonyms"},"_publications":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/publications"},"_namespace":null},{"id":6233,"version":2,"created":1554901158000,"modified":1554901165000,"deprecated":false,"name":"Collagen alpha-1(XI) chain","accession":"P12107","gene":"COL11A1","description":"May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1551644772626615,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":138.365109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.00058717698813,"pubTatorScore":1.9880810949935024,"self":"https://pharos.nih.gov/idg/api/v1/targets(6233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/publications"},"_namespace":null},{"id":6234,"version":2,"created":1554901166000,"modified":1554901170000,"deprecated":false,"name":"Lipoma-preferred partner","accession":"Q93052","gene":"LPP","description":"May play a structural role at sites of cell adhesion in maintaining cell shape and motility. 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Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7794891990315715,"antibodyCount":164,"monoclonalCount":49,"pubmedCount":null,"jensenScore":582.593297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.874140679759776,"pubTatorScore":1.6565088618802581,"self":"https://pharos.nih.gov/idg/api/v1/targets(6234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/properties"},"_links":{"count":1137,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/publications"},"_namespace":null},{"id":6235,"version":2,"created":1554901172000,"modified":1554901176000,"deprecated":false,"name":"Collagen alpha-2(VI) chain","accession":"P12110","gene":"COL6A2","description":"Collagen VI acts as a cell-binding protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8053053176660012,"antibodyCount":151,"monoclonalCount":17,"pubmedCount":null,"jensenScore":59.19986,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.160002608733954,"pubTatorScore":1.746710489526803,"self":"https://pharos.nih.gov/idg/api/v1/targets(6235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/properties"},"_links":{"count":1215,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/publications"},"_namespace":null},{"id":6236,"version":3,"created":1554901177000,"modified":1555036786000,"deprecated":false,"name":"V-type proton ATPase 116 kDa subunit a isoform 1","accession":"Q93050","gene":"ATP6V0A1","description":"Required for assembly and activity of the vacuolar ATPase. 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The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2482583569824093,"antibodyCount":343,"monoclonalCount":220,"pubmedCount":null,"jensenScore":167.599696,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":25.691397392598127,"pubTatorScore":2.085588176723918,"self":"https://pharos.nih.gov/idg/api/v1/targets(6237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/properties"},"_links":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/publications"},"_namespace":null},{"id":6238,"version":2,"created":1554901184000,"modified":1554901187000,"deprecated":false,"name":"NEDD4-binding protein 3","accession":"O15049","gene":"N4BP3","description":"Plays a role in axon and dendrite arborization during cranial nerve development. 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Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). 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Not involved in glycosylation of erythropoietin (EPO).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6699602258968655,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.390584,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.05040600822066,"pubTatorScore":0.735826924262557,"self":"https://pharos.nih.gov/idg/api/v1/targets(6501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/publications"},"_namespace":null},{"id":6502,"version":2,"created":1554902360000,"modified":1554902362000,"deprecated":false,"name":"SLAIN motif-containing 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.648631362283689,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(6543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/properties"},"_links":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/publications"},"_namespace":null},{"id":6544,"version":2,"created":1554902547000,"modified":1554902548000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-39","accession":"P01597","gene":"IGKV1-39","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2035081996554204,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/properties"},"_links":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/publications"},"_namespace":null},{"id":6545,"version":2,"created":1554902548000,"modified":1554902548000,"deprecated":false,"name":"Putative uncharacterized protein SERTAD4-AS1","accession":"Q5TG53","gene":"SERTAD4-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.24271481131519,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6545)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/publications"},"_namespace":null},{"id":6546,"version":2,"created":1554902548000,"modified":1554902549000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-33","accession":"P01594","gene":"IGKV1-33","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). 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ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.21263801451622,"antibodyCount":618,"monoclonalCount":334,"pubmedCount":null,"jensenScore":144.704061,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":32.07070666937967,"pubTatorScore":2.071528439725327,"self":"https://pharos.nih.gov/idg/api/v1/targets(6558)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/publications"},"_namespace":null},{"id":6559,"version":3,"created":1554903227000,"modified":1555036992000,"deprecated":false,"name":"Protein Hikeshi","accession":"Q53FT3","gene":"HIKESHI","description":"Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.029045397407043,"antibodyCount":121,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.605356,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":0.8314431375003237,"self":"https://pharos.nih.gov/idg/api/v1/targets(6559)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/publications"},"_namespace":null},{"id":6560,"version":2,"created":1554903230000,"modified":1554903235000,"deprecated":false,"name":"Peroxisomal targeting signal 1 receptor","accession":"P50542","gene":"PEX5","description":"Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4312575052995067,"antibodyCount":138,"monoclonalCount":39,"pubmedCount":null,"jensenScore":272.807349,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.49445066000761,"pubTatorScore":2.1082143923755186,"self":"https://pharos.nih.gov/idg/api/v1/targets(6560)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/properties"},"_links":{"count":1433,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/links"},"_synonyms":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/publications"},"_namespace":null},{"id":6561,"version":4,"created":1554903237000,"modified":1555036994000,"deprecated":false,"name":"Inosine-5'-monophosphate dehydrogenase 2","accession":"P12268","gene":"IMPDH2","description":"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.980401474138919,"antibodyCount":247,"monoclonalCount":15,"pubmedCount":null,"jensenScore":94.340503,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":44.41236132409953,"pubTatorScore":1.9216572545436994,"self":"https://pharos.nih.gov/idg/api/v1/targets(6561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/properties"},"_links":{"count":1597,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/publications"},"_namespace":null},{"id":6562,"version":2,"created":1554903404000,"modified":1554903407000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF8","accession":"O76064","gene":"RNF8","description":"E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (PubMed:23233665). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. 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This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.35295951414504,"antibodyCount":122,"monoclonalCount":21,"pubmedCount":null,"jensenScore":2270.409413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.90068017001074,"pubTatorScore":3.2190546637674053,"self":"https://pharos.nih.gov/idg/api/v1/targets(6564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":474,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/properties"},"_links":{"count":2237,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/links"},"_synonyms":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/publications"},"_namespace":null},{"id":6565,"version":2,"created":1554903774000,"modified":1554903778000,"deprecated":false,"name":"Parathyroid hormone-related protein","accession":"P12272","gene":"PTHLH","description":"Osteostatin is a potent inhibitor of osteoclastic bone resorption.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.276757833301795,"antibodyCount":283,"monoclonalCount":50,"pubmedCount":null,"jensenScore":2151.492775,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.84401001820878,"pubTatorScore":3.1434772469216337,"self":"https://pharos.nih.gov/idg/api/v1/targets(6565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":585,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/synonyms"},"_publications":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/publications"},"_namespace":null},{"id":6566,"version":2,"created":1554903781000,"modified":1554903783000,"deprecated":false,"name":"Probable cytosolic iron-sulfur protein assembly protein CIAO1","accession":"O76071","gene":"CIAO1","description":"Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. 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Activates the MAPK and Elk-1 signal transduction pathway (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2489473425915136,"antibodyCount":294,"monoclonalCount":54,"pubmedCount":null,"jensenScore":187.345177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.06129016231813,"pubTatorScore":2.0162368524310503,"self":"https://pharos.nih.gov/idg/api/v1/targets(6568)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/publications"},"_namespace":null},{"id":6569,"version":3,"created":1554903789000,"modified":1555037004000,"deprecated":false,"name":"Chitinase-3-like protein 1","accession":"P36222","gene":"CHI3L1","description":"Carbohydrate-binding lectin with a preference for chitin. 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Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.82180030085194,"antibodyCount":299,"monoclonalCount":80,"pubmedCount":null,"jensenScore":732.923424,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.02047921641284,"pubTatorScore":2.824143272410676,"self":"https://pharos.nih.gov/idg/api/v1/targets(6569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":603,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/properties"},"_links":{"count":1258,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/synonyms"},"_publications":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/publications"},"_namespace":null},{"id":6570,"version":2,"created":1554903795000,"modified":1554903798000,"deprecated":false,"name":"Retinaldehyde-binding protein 1","accession":"P12271","gene":"RLBP1","description":"Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. 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The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1496423694359628,"antibodyCount":108,"monoclonalCount":65,"pubmedCount":null,"jensenScore":143.368044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.50904052974142,"pubTatorScore":2.0119436453624466,"self":"https://pharos.nih.gov/idg/api/v1/targets(6570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/properties"},"_links":{"count":677,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/publications"},"_namespace":null},{"id":6571,"version":2,"created":1554903798000,"modified":1554903800000,"deprecated":false,"name":"Zinc finger protein 485","accession":"Q8NCK3","gene":"ZNF485","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":55,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.12479086734316,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/publications"},"_namespace":null},{"id":6572,"version":2,"created":1554903801000,"modified":1554903805000,"deprecated":false,"name":"Nucleoprotein TPR","accession":"P12270","gene":"TPR","description":"Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.114912562249106,"antibodyCount":161,"monoclonalCount":39,"pubmedCount":null,"jensenScore":135.63141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.21468307353099,"pubTatorScore":2.486023717944981,"self":"https://pharos.nih.gov/idg/api/v1/targets(6572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":599,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/publications"},"_namespace":null},{"id":6573,"version":3,"created":1554903807000,"modified":1555037006000,"deprecated":false,"name":"Monocarboxylate transporter 11","accession":"Q8NCK7","gene":"SLC16A11","description":"Proton-linked monocarboxylate transporter. 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Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.8378739024209555,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.352328,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":20.123539891901178,"pubTatorScore":0.7999965278181024,"self":"https://pharos.nih.gov/idg/api/v1/targets(6573)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/publications"},"_namespace":null},{"id":6574,"version":3,"created":1554903809000,"modified":1555037007000,"deprecated":false,"name":"Interleukin-2 receptor subunit alpha","accession":"P01589","gene":"IL2RA","description":"Receptor for interleukin-2. 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Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. 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The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.8408004885822902,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":66.240306,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.0903524260337,"pubTatorScore":2.163887917855051,"self":"https://pharos.nih.gov/idg/api/v1/targets(6734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/publications"},"_namespace":null},{"id":6735,"version":2,"created":1554904397000,"modified":1554904399000,"deprecated":false,"name":"Uncharacterized protein C1orf131","accession":"Q8NDD1","gene":"C1orf131","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/publications"},"_namespace":null},{"id":6736,"version":2,"created":1554904399000,"modified":1554904403000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 17","accession":"Q8IVW1","gene":"ARL17A","description":"GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. 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Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth 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Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1. Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). 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May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. 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The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.6355428148811706,"antibodyCount":136,"monoclonalCount":14,"pubmedCount":null,"jensenScore":400.265288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":2.5913049347636083,"self":"https://pharos.nih.gov/idg/api/v1/targets(7078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(7078)/properties"},"_links":{"count":1153,"href":"https://pharos.nih.gov/idg/api/v1/targets(7078)/links"},"_synonyms":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(7078)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(7078)/publications"},"_namespace":null},{"id":7079,"version":2,"created":1554906303000,"modified":1554906305000,"deprecated":false,"name":"SLIT-ROBO Rho GTPase-activating protein 2C","accession":"P0DJJ0","gene":"SRGAP2C","description":"Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0998453178813135,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.742738,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.824453529427505,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(7079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(7079)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(7079)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(7079)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(7079)/publications"},"_namespace":null},{"id":7080,"version":2,"created":1554906306000,"modified":1554906330000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 1","accession":"Q09470","gene":"KCNA1","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:23903368, PubMed:19307729).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.595641873872633,"antibodyCount":313,"monoclonalCount":42,"pubmedCount":null,"jensenScore":379.072745,"patentCount":8121,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.41989509331221,"pubTatorScore":2.486233967513306,"self":"https://pharos.nih.gov/idg/api/v1/targets(7080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(7080)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(7080)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(7080)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(7080)/publications"},"_namespace":null},{"id":7081,"version":2,"created":1554906331000,"modified":1554906333000,"deprecated":false,"name":"Zinc finger protein 83","accession":"P51522","gene":"ZNF83","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.0,"antibodyCount":104,"monoclonalCount":11,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.559341569478416,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(7081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(7081)/properties"},"_links":{"count":1080,"href":"https://pharos.nih.gov/idg/api/v1/targets(7081)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(7081)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(7081)/publications"},"_namespace":null},{"id":7082,"version":2,"created":1554906334000,"modified":1554906337000,"deprecated":false,"name":"Glycerol-3-phosphate acyltransferase 3","accession":"Q53EU6","gene":"GPAT3","description":"May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5493866683018616,"antibodyCount":138,"monoclonalCount":12,"pubmedCount":null,"jensenScore":31.962102,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.515132355013282,"self":"https://pharos.nih.gov/idg/api/v1/targets(7082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(7082)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(7082)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(7082)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(7082)/publications"},"_namespace":null},{"id":7083,"version":2,"created":1554906338000,"modified":1554906340000,"deprecated":false,"name":"Paired box protein Pax-1","accession":"P15863","gene":"PAX1","description":"This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.033389013318066,"antibodyCount":245,"monoclonalCount":2,"pubmedCount":null,"jensenScore":106.058392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.614081399417547,"pubTatorScore":1.6840142928412818,"self":"https://pharos.nih.gov/idg/api/v1/targets(7083)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/properties"},"_links":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/publications"},"_namespace":null},{"id":7084,"version":2,"created":1554906341000,"modified":1554906343000,"deprecated":false,"name":"Zinc finger protein 84","accession":"P51523","gene":"ZNF84","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.5795824276334393,"antibodyCount":27,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.236231,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.614047979385607,"pubTatorScore":0.7114556877516415,"self":"https://pharos.nih.gov/idg/api/v1/targets(7084)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/publications"},"_namespace":null},{"id":7085,"version":2,"created":1554906344000,"modified":1554906346000,"deprecated":false,"name":"Kyphoscoliosis peptidase","accession":"Q8NBH2","gene":"KY","description":"Probable cytoskeleton-associated protease required for normal muscle growth. 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May act by cleaving muscle-specific proteins such as FLNC (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.3357921033708414,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.537872280227052,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7085)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/publications"},"_namespace":null},{"id":7086,"version":3,"created":1554906346000,"modified":1555037302000,"deprecated":false,"name":"Calcitonin","accession":"P01258","gene":"CALCA","description":"Katacalcin is a potent plasma calcium-lowering peptide.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.7035542057936035,"antibodyCount":1309,"monoclonalCount":653,"pubmedCount":null,"jensenScore":8831.255397,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":0.0,"pubTatorScore":3.2813951325409683,"self":"https://pharos.nih.gov/idg/api/v1/targets(7086)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/properties"},"_links":{"count":547,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/synonyms"},"_publications":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/publications"},"_namespace":null},{"id":7087,"version":3,"created":1554906352000,"modified":1555037304000,"deprecated":false,"name":"NADH-ubiquinone oxidoreductase chain 2","accession":"P03891","gene":"MT-ND2","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.908452621718699,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":775.603588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":8.97191855239277,"pubTatorScore":2.4946564221704794,"self":"https://pharos.nih.gov/idg/api/v1/targets(7087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/links"},"_synonyms":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/publications"},"_namespace":null},{"id":7088,"version":3,"created":1554906357000,"modified":1555037307000,"deprecated":false,"name":"Troponin C, skeletal muscle","accession":"P02585","gene":"TNNC2","description":"Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8504984721692731,"antibodyCount":102,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.676473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":25.601115586556705,"pubTatorScore":0.9582452359555863,"self":"https://pharos.nih.gov/idg/api/v1/targets(7088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/publications"},"_namespace":null},{"id":7089,"version":3,"created":1554906360000,"modified":1555037308000,"deprecated":false,"name":"Probable global transcription activator SNF2L2","accession":"P51531","gene":"SMARCA2","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.5743451588977386,"antibodyCount":153,"monoclonalCount":16,"pubmedCount":null,"jensenScore":345.339392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":61.31352944584358,"pubTatorScore":2.0581950922751036,"self":"https://pharos.nih.gov/idg/api/v1/targets(7089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":591,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/properties"},"_links":{"count":1375,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/synonyms"},"_publications":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/publications"},"_namespace":null},{"id":7090,"version":3,"created":1554906367000,"modified":1555037310000,"deprecated":false,"name":"DNA replication ATP-dependent helicase/nuclease DNA2","accession":"P51530","gene":"DNA2","description":"Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.421593469184617,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":256.063146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":39.00538881427704,"pubTatorScore":2.2179203119453748,"self":"https://pharos.nih.gov/idg/api/v1/targets(7090)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/publications"},"_namespace":null},{"id":7091,"version":2,"created":1554906373000,"modified":1554906377000,"deprecated":false,"name":"NADH-ubiquinone oxidoreductase chain 3","accession":"P03897","gene":"MT-ND3","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.8291547268286688,"antibodyCount":93,"monoclonalCount":0,"pubmedCount":null,"jensenScore":655.629932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.475154467917231,"pubTatorScore":2.2360802133123254,"self":"https://pharos.nih.gov/idg/api/v1/targets(7091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/links"},"_synonyms":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/publications"},"_namespace":null},{"id":7092,"version":3,"created":1554906379000,"modified":1555037312000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 8","accession":"P40818","gene":"USP8","description":"Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. 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Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5199118141846097,"antibodyCount":385,"monoclonalCount":64,"pubmedCount":null,"jensenScore":33.968695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.37038458333162,"pubTatorScore":1.8709756502882282,"self":"https://pharos.nih.gov/idg/api/v1/targets(7093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/publications"},"_namespace":null},{"id":7094,"version":2,"created":1554906388000,"modified":1554906391000,"deprecated":false,"name":"Growth/differentiation factor 6","accession":"Q6KF10","gene":"GDF6","description":"Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. 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This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.310353783384563,"antibodyCount":110,"monoclonalCount":0,"pubmedCount":null,"jensenScore":205.362909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.545463618843588,"pubTatorScore":2.51841468961661,"self":"https://pharos.nih.gov/idg/api/v1/targets(7094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/properties"},"_links":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/publications"},"_namespace":null},{"id":7095,"version":3,"created":1554906391000,"modified":1555037316000,"deprecated":false,"name":"Transcription activator BRG1","accession":"P51532","gene":"SMARCA4","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). 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Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). 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Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.588255746813383,"antibodyCount":481,"monoclonalCount":322,"pubmedCount":null,"jensenScore":424.954675,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.83792061126843,"pubTatorScore":2.7083876995597382,"self":"https://pharos.nih.gov/idg/api/v1/targets(7206)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":646,"href":"https://pharos.nih.gov/idg/api/v1/targets(7206)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(7206)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(7206)/synonyms"},"_publications":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(7206)/publications"},"_namespace":null},{"id":7207,"version":3,"created":1554907150000,"modified":1555037387000,"deprecated":false,"name":"CaM kinase-like vesicle-associated protein","accession":"Q8NCB2","gene":"CAMKV","description":"Does not appear to have detectable kinase activity.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.635357090271123,"antibodyCount":153,"monoclonalCount":21,"pubmedCount":null,"jensenScore":42.558018,"patentCount":3078,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":43,"knowledgeAvailability":30.03689492463152,"pubTatorScore":0.3107899294630116,"self":"https://pharos.nih.gov/idg/api/v1/targets(7207)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(7207)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(7207)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(7207)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(7207)/publications"},"_namespace":null},{"id":7208,"version":2,"created":1554907154000,"modified":1554907171000,"deprecated":false,"name":"Ras guanyl-releasing protein 3","accession":"Q8IV61","gene":"RASGRP3","description":"Guanine nucleotide exchange factor (GEF) for Ras and Rap1.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.5086174325132342,"antibodyCount":186,"monoclonalCount":130,"pubmedCount":null,"jensenScore":36.29167,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.34205432743651,"pubTatorScore":1.383355164902351,"self":"https://pharos.nih.gov/idg/api/v1/targets(7208)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(7208)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(7208)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(7208)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(7208)/publications"},"_namespace":null},{"id":7209,"version":2,"created":1554907172000,"modified":1554907173000,"deprecated":false,"name":"Colorectal cancer-associated protein 1","accession":"Q6ZS62","gene":"COLCA1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.10591549904670128,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.317514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.317608634001814,"pubTatorScore":0.43933269383026263,"self":"https://pharos.nih.gov/idg/api/v1/targets(7209)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(7209)/properties"},"_links":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(7209)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(7209)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(7209)/publications"},"_namespace":null},{"id":7210,"version":2,"created":1554907173000,"modified":1554907177000,"deprecated":false,"name":"Dual specificity tyrosine-phosphorylation-regulated kinase 3","accession":"O43781","gene":"DYRK3","description":"Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. 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Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4033259476132205,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":252.675804,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.268531461780846,"pubTatorScore":1.23636930517484,"self":"https://pharos.nih.gov/idg/api/v1/targets(7304)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/publications"},"_namespace":null},{"id":7305,"version":2,"created":1554907697000,"modified":1554907701000,"deprecated":false,"name":"HIV Tat-specific factor 1","accession":"O43719","gene":"HTATSF1","description":"Functions as a general transcription factor playing a role in the process of transcriptional elongation. 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Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By 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Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.381206289739463,"antibodyCount":160,"monoclonalCount":10,"pubmedCount":null,"jensenScore":24.468833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.024105914769773,"pubTatorScore":1.2419354033760226,"self":"https://pharos.nih.gov/idg/api/v1/targets(7336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/publications"},"_namespace":null},{"id":7337,"version":2,"created":1554907912000,"modified":1554907915000,"deprecated":false,"name":"Cartilage intermediate layer protein 2","accession":"Q8IUL8","gene":"CILP2","description":"May play a role in cartilage scaffolding.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8055148248157916,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.463292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.52487740554821,"pubTatorScore":0.84741846957087,"self":"https://pharos.nih.gov/idg/api/v1/targets(7337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/publications"},"_namespace":null},{"id":7338,"version":2,"created":1554907915000,"modified":1554907917000,"deprecated":false,"name":"Cerebellin-2","accession":"Q8IUK8","gene":"CBLN2","description":"May play role in synaptogenesis induction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9711708903611765,"antibodyCount":135,"monoclonalCount":5,"pubmedCount":null,"jensenScore":7.772301,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.499156144574304,"pubTatorScore":0.5544313713704123,"self":"https://pharos.nih.gov/idg/api/v1/targets(7338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/properties"},"_links":{"count":599,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/publications"},"_namespace":null},{"id":7339,"version":3,"created":1554907918000,"modified":1555037459000,"deprecated":false,"name":"Probable 18S rRNA (guanine-N(7))-methyltransferase","accession":"O43709","gene":"BUD23","description":"S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). 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Required for chromatoid body (CB) assembly (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.8467199060318634,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.831504,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.487500344429044,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(7526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/properties"},"_links":{"count":738,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/publications"},"_namespace":null},{"id":7527,"version":2,"created":1554908687000,"modified":1554908691000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 11","accession":"Q6UB99","gene":"ANKRD11","description":"Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5558802244572036,"antibodyCount":93,"monoclonalCount":11,"pubmedCount":null,"jensenScore":339.66501,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.65892752555374,"pubTatorScore":2.0206951217886604,"self":"https://pharos.nih.gov/idg/api/v1/targets(7527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/properties"},"_links":{"count":1122,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/publications"},"_namespace":null},{"id":7528,"version":2,"created":1554908692000,"modified":1554908694000,"deprecated":false,"name":"Synaptotagmin-14","accession":"Q8NB59","gene":"SYT14","description":"May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. 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Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.6214276894319406,"antibodyCount":554,"monoclonalCount":221,"pubmedCount":null,"jensenScore":397.933373,"patentCount":70161,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.694175943417434,"pubTatorScore":2.5320733644561417,"self":"https://pharos.nih.gov/idg/api/v1/targets(7529)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/properties"},"_links":{"count":1249,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/synonyms"},"_publications":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/publications"},"_namespace":null},{"id":7530,"version":2,"created":1554908892000,"modified":1554908900000,"deprecated":false,"name":"Serine/threonine-protein kinase D2","accession":"Q9BZL6","gene":"PRKD2","description":"Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.4620344024579455,"antibodyCount":417,"monoclonalCount":91,"pubmedCount":null,"jensenScore":23.4013,"patentCount":10073,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.340077053494674,"pubTatorScore":1.3961999575493984,"self":"https://pharos.nih.gov/idg/api/v1/targets(7530)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/publications"},"_namespace":null},{"id":7531,"version":2,"created":1554908901000,"modified":1554908904000,"deprecated":false,"name":"Phospholipid-transporting ATPase IG","accession":"Q8NB49","gene":"ATP11C","description":"Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By 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Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.9048099633879507,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.769727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.2542300160895,"pubTatorScore":0.7978608097508584,"self":"https://pharos.nih.gov/idg/api/v1/targets(7539)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/publications"},"_namespace":null},{"id":7540,"version":3,"created":1554908928000,"modified":1555037570000,"deprecated":false,"name":"C-C chemokine receptor type 8","accession":"P51685","gene":"CCR8","description":"Receptor for the chemokine CCL1/SCYA1/I-309. 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Alternative coreceptor with CD4 for HIV-1 infection.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.154063340998809,"antibodyCount":412,"monoclonalCount":75,"pubmedCount":null,"jensenScore":145.725363,"patentCount":23134,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.41030788652638,"pubTatorScore":1.9135887394728122,"self":"https://pharos.nih.gov/idg/api/v1/targets(7540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/properties"},"_links":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/publications"},"_namespace":null},{"id":7541,"version":3,"created":1554908945000,"modified":1555037573000,"deprecated":false,"name":"C-C chemokine receptor type 6","accession":"P51684","gene":"CCR6","description":"Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 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ATP2A2 inhibition is alleviated by PLN phosphorylation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9370061014352202,"antibodyCount":365,"monoclonalCount":27,"pubmedCount":null,"jensenScore":85.849331,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.45505919448654,"pubTatorScore":1.7897515903422132,"self":"https://pharos.nih.gov/idg/api/v1/targets(7730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/publications"},"_namespace":null},{"id":7731,"version":3,"created":1554911398000,"modified":1555037763000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 24","accession":"Q9UPU5","gene":"USP24","description":"Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. 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Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. 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Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.364446892244434,"antibodyCount":605,"monoclonalCount":187,"pubmedCount":null,"jensenScore":252.714158,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.53455283641345,"pubTatorScore":2.6214795243437865,"self":"https://pharos.nih.gov/idg/api/v1/targets(7738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/properties"},"_links":{"count":422,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/synonyms"},"_publications":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/publications"},"_namespace":null},{"id":7739,"version":2,"created":1554911436000,"modified":1554911439000,"deprecated":false,"name":"Homeobox protein Hox-D8","accession":"P13378","gene":"HOXD8","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0660743871062452,"antibodyCount":190,"monoclonalCount":62,"pubmedCount":null,"jensenScore":11.336189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.540554908607728,"pubTatorScore":1.1589246299630405,"self":"https://pharos.nih.gov/idg/api/v1/targets(7739)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/properties"},"_links":{"count":704,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/publications"},"_namespace":null},{"id":7740,"version":3,"created":1554911439000,"modified":1555037775000,"deprecated":false,"name":"Host cell factor 1","accession":"P51610","gene":"HCFC1","description":"Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5645299125613548,"antibodyCount":172,"monoclonalCount":3,"pubmedCount":null,"jensenScore":370.784514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.3604208028298,"pubTatorScore":3.3649762902060703,"self":"https://pharos.nih.gov/idg/api/v1/targets(7740)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/synonyms"},"_publications":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/publications"},"_namespace":null},{"id":7741,"version":2,"created":1554911444000,"modified":1554911446000,"deprecated":false,"name":"Cysteine-rich protein 2","accession":"P52943","gene":"CRIP2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0017901983904465,"antibodyCount":143,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.417129,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.445070863530596,"pubTatorScore":1.970306439392441,"self":"https://pharos.nih.gov/idg/api/v1/targets(7741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/publications"},"_namespace":null},{"id":7742,"version":3,"created":1554911447000,"modified":1555037780000,"deprecated":false,"name":"Cytoplasmic polyadenylation element-binding protein 1","accession":"Q9BZB8","gene":"CPEB1","description":"Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2390605916731126,"antibodyCount":222,"monoclonalCount":3,"pubmedCount":null,"jensenScore":178.761348,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":35.74518627464951,"pubTatorScore":1.8720380411152384,"self":"https://pharos.nih.gov/idg/api/v1/targets(7742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/publications"},"_namespace":null},{"id":7743,"version":3,"created":1554911452000,"modified":1555037782000,"deprecated":false,"name":"Teratocarcinoma-derived growth factor 1","accession":"P13385","gene":"TDGF1","description":"GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9974615985540143,"antibodyCount":423,"monoclonalCount":109,"pubmedCount":null,"jensenScore":160.367803,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":27.042639450032397,"pubTatorScore":1.8758829351305462,"self":"https://pharos.nih.gov/idg/api/v1/targets(7743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/properties"},"_links":{"count":799,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/publications"},"_namespace":null},{"id":7744,"version":3,"created":1554911455000,"modified":1555037784000,"deprecated":false,"name":"Interleukin-1 receptor-associated kinase 1","accession":"P51617","gene":"IRAK1","description":"Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. 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The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. 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Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.6079963610931194,"antibodyCount":317,"monoclonalCount":66,"pubmedCount":null,"jensenScore":401.385604,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.233640093146022,"pubTatorScore":1.6154821707651217,"self":"https://pharos.nih.gov/idg/api/v1/targets(7822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/properties"},"_links":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/publications"},"_namespace":null},{"id":7823,"version":3,"created":1554912212000,"modified":1555037827000,"deprecated":false,"name":"F-actin-capping protein subunit alpha-1","accession":"P52907","gene":"CAPZA1","description":"F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. 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Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.842407252796072,"antibodyCount":357,"monoclonalCount":18,"pubmedCount":null,"jensenScore":70.463112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.789099601863356,"pubTatorScore":1.3462275391341636,"self":"https://pharos.nih.gov/idg/api/v1/targets(7899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/properties"},"_links":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/publications"},"_namespace":null},{"id":7900,"version":3,"created":1554912597000,"modified":1555037900000,"deprecated":false,"name":"S-adenosylhomocysteine hydrolase-like protein 1","accession":"O43865","gene":"AHCYL1","description":"Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.6540703755005843,"antibodyCount":128,"monoclonalCount":33,"pubmedCount":null,"jensenScore":46.170292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":42.44592700315272,"pubTatorScore":1.429146412332185,"self":"https://pharos.nih.gov/idg/api/v1/targets(7900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/properties"},"_links":{"count":1150,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/publications"},"_namespace":null},{"id":7901,"version":2,"created":1554912603000,"modified":1554912606000,"deprecated":false,"name":"Cytochrome c oxidase subunit 7C, mitochondrial","accession":"P15954","gene":"COX7C","description":"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.0278288320108104,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.085583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.90319669157363,"pubTatorScore":0.47506813175727397,"self":"https://pharos.nih.gov/idg/api/v1/targets(7901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/publications"},"_namespace":null},{"id":7902,"version":3,"created":1554912607000,"modified":1555037902000,"deprecated":false,"name":"Acylphosphatase-2","accession":"P14621","gene":"ACYP2","description":"Its physiological role is not yet clear.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4080244419664905,"antibodyCount":62,"monoclonalCount":12,"pubmedCount":null,"jensenScore":25.637704,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":37.330112220585534,"pubTatorScore":0.7163014846588348,"self":"https://pharos.nih.gov/idg/api/v1/targets(7902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/publications"},"_namespace":null},{"id":7903,"version":2,"created":1554912610000,"modified":1554912615000,"deprecated":false,"name":"Fibronectin type III domain-containing protein 3B","accession":"Q53EP0","gene":"FNDC3B","description":"May be a positive regulator of adipogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3812719017053383,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.979298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.495898292282526,"pubTatorScore":0.961458209232899,"self":"https://pharos.nih.gov/idg/api/v1/targets(7903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/properties"},"_links":{"count":980,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/publications"},"_namespace":null},{"id":7904,"version":3,"created":1554912616000,"modified":1555037903000,"deprecated":false,"name":"Indoleamine 2,3-dioxygenase 2","accession":"Q6ZQW0","gene":"IDO2","description":"Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.966648230767873,"antibodyCount":244,"monoclonalCount":80,"pubmedCount":null,"jensenScore":90.054914,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":19.322298249180562,"pubTatorScore":1.8688146437731492,"self":"https://pharos.nih.gov/idg/api/v1/targets(7904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/properties"},"_links":{"count":479,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/publications"},"_namespace":null},{"id":7905,"version":3,"created":1554912618000,"modified":1554912714000,"deprecated":false,"name":"Macrophage metalloelastase","accession":"P39900","gene":"MMP12","description":"May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":null,"antibodyCount":447,"monoclonalCount":63,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.709433757209126,"pubTatorScore":2.4479503051459246,"self":"https://pharos.nih.gov/idg/api/v1/targets(7905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/properties"},"_links":{"count":630,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/links"},"_synonyms":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/publications"},"_namespace":null},{"id":7906,"version":2,"created":1554912716000,"modified":1554912716000,"deprecated":false,"name":"Olfactory receptor 2T1","accession":"O43869","gene":"OR2T1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":336,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.687006775234671,"pubTatorScore":1.5200466079834543,"self":"https://pharos.nih.gov/idg/api/v1/targets(7906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/properties"},"_links":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/publications"},"_namespace":null},{"id":7907,"version":2,"created":1554912717000,"modified":1554912719000,"deprecated":false,"name":"Otoancorin","accession":"Q7RTW8","gene":"OTOA","description":"May act as an adhesion molecule.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3147121347393331,"antibodyCount":58,"monoclonalCount":2,"pubmedCount":null,"jensenScore":20.407249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.275148291692467,"pubTatorScore":0.7793559034007393,"self":"https://pharos.nih.gov/idg/api/v1/targets(7907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/properties"},"_links":{"count":707,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/publications"},"_namespace":null},{"id":7908,"version":2,"created":1554912719000,"modified":1554912723000,"deprecated":false,"name":"Sodium/nucleoside cotransporter 2","accession":"O43868","gene":"SLC28A2","description":"Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.8786979202500227,"antibodyCount":122,"monoclonalCount":8,"pubmedCount":null,"jensenScore":73.175782,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.35909516276787,"pubTatorScore":1.7555505833353395,"self":"https://pharos.nih.gov/idg/api/v1/targets(7908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/publications"},"_namespace":null},{"id":7909,"version":3,"created":1554912724000,"modified":1555037904000,"deprecated":false,"name":"Uncharacterized protein C16orf46","accession":"Q6P387","gene":"C16orf46","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/publications"},"_namespace":null},{"id":7910,"version":3,"created":1554912727000,"modified":1555037907000,"deprecated":false,"name":"Apolipoprotein C-III","accession":"P02656","gene":"APOC3","description":"Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9334802697065845,"antibodyCount":267,"monoclonalCount":32,"pubmedCount":null,"jensenScore":875.184782,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":29.630276808634918,"pubTatorScore":2.8314177801500366,"self":"https://pharos.nih.gov/idg/api/v1/targets(7910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":651,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/synonyms"},"_publications":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/publications"},"_namespace":null},{"id":7911,"version":3,"created":1554912733000,"modified":1555037910000,"deprecated":false,"name":"Apolipoprotein C-II","accession":"P02655","gene":"APOC2","description":"Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5108616915720785,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":342.659955,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.070775621743326,"pubTatorScore":2.5184376486935918,"self":"https://pharos.nih.gov/idg/api/v1/targets(7911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/properties"},"_links":{"count":755,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/publications"},"_namespace":null},{"id":7912,"version":2,"created":1554912736000,"modified":1554912740000,"deprecated":false,"name":"Apolipoprotein C-I","accession":"P02654","gene":"APOC1","description":"Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. 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Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. 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The formation of this structure appears to drive apposition and subsequent fusion of membranes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.65033401590337,"antibodyCount":184,"monoclonalCount":19,"pubmedCount":null,"jensenScore":4159.37904,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.69700714802079,"pubTatorScore":1.6798819421128623,"self":"https://pharos.nih.gov/idg/api/v1/targets(7983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/publications"},"_namespace":null},{"id":7984,"version":2,"created":1554912987000,"modified":1554912990000,"deprecated":false,"name":"Magnesium transporter NIPA1","accession":"Q7RTP0","gene":"NIPA1","description":"Acts as a Mg(2+) transporter. 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Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.855432018879203,"antibodyCount":180,"monoclonalCount":9,"pubmedCount":null,"jensenScore":697.433929,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":42.57331945115158,"pubTatorScore":2.741023364525427,"self":"https://pharos.nih.gov/idg/api/v1/targets(7987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/publications"},"_namespace":null},{"id":7988,"version":2,"created":1554913001000,"modified":1554913001000,"deprecated":false,"name":"Putative uncharacterized protein PNAS-138","accession":"Q9BZS9","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(7988)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(7988)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(7988)/synonyms"},"_publications":null,"_namespace":null},{"id":7989,"version":2,"created":1554913001000,"modified":1554913003000,"deprecated":false,"name":"Uncharacterized protein C22orf46","accession":"C9J442","gene":"C22orf46","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/publications"},"_namespace":null},{"id":7990,"version":3,"created":1554913004000,"modified":1555037938000,"deprecated":false,"name":"Forkhead box protein P3","accession":"Q9BZS1","gene":"FOXP3","description":"Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). 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Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.80046421880166,"antibodyCount":1358,"monoclonalCount":674,"pubmedCount":null,"jensenScore":6233.752801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.40461240001423,"pubTatorScore":3.39771390058705,"self":"https://pharos.nih.gov/idg/api/v1/targets(7990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1160,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/properties"},"_links":{"count":1675,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/synonyms"},"_publications":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/publications"},"_namespace":null},{"id":7991,"version":2,"created":1554913015000,"modified":1554913015000,"deprecated":false,"name":"Endogenous retrovirus group K member 11 Pol protein","accession":"Q9UQG0","gene":"ERVK-11","description":"Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/publications"},"_namespace":null},{"id":7992,"version":2,"created":1554913015000,"modified":1554913017000,"deprecated":false,"name":"Forkhead box protein I2","accession":"Q6ZQN5","gene":"FOXI2","description":"Possible transcriptional activator.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.7783877272979401,"antibodyCount":70,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.224426,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.199020197786773,"pubTatorScore":-0.40654002843091314,"self":"https://pharos.nih.gov/idg/api/v1/targets(7992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/properties"},"_links":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/publications"},"_namespace":null},{"id":7993,"version":3,"created":1554913017000,"modified":1555037943000,"deprecated":false,"name":"Tubulin alpha-1A chain","accession":"Q71U36","gene":"TUBA1A","description":"Tubulin is the major constituent of microtubules. 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May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.4603180689520618,"antibodyCount":58,"monoclonalCount":2,"pubmedCount":null,"jensenScore":28.356557,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.564051797325327,"pubTatorScore":0.9307646841902517,"self":"https://pharos.nih.gov/idg/api/v1/targets(7996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/publications"},"_namespace":null},{"id":7997,"version":3,"created":1554913035000,"modified":1555037946000,"deprecated":false,"name":"Reticulon-4 receptor","accession":"Q9BZR6","gene":"RTN4R","description":"Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6019974574249014,"antibodyCount":232,"monoclonalCount":59,"pubmedCount":null,"jensenScore":411.784745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.6509276537615,"pubTatorScore":2.1477842538722394,"self":"https://pharos.nih.gov/idg/api/v1/targets(7997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/publications"},"_namespace":null},{"id":7998,"version":3,"created":1554913039000,"modified":1555037947000,"deprecated":false,"name":"Toll-interacting protein","accession":"Q9H0E2","gene":"TOLLIP","description":"Component of the signaling pathway of IL-1 and Toll-like receptors. 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The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8754370906872955,"antibodyCount":423,"monoclonalCount":136,"pubmedCount":null,"jensenScore":81.575101,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.20034924316368,"pubTatorScore":1.6888769432708757,"self":"https://pharos.nih.gov/idg/api/v1/targets(7998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/properties"},"_links":{"count":1142,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/publications"},"_namespace":null},{"id":7999,"version":3,"created":1554913044000,"modified":1555037949000,"deprecated":false,"name":"Regenerating islet-derived protein 3-alpha","accession":"Q06141","gene":"REG3A","description":"Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.617901872664404,"antibodyCount":321,"monoclonalCount":37,"pubmedCount":null,"jensenScore":412.969734,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":20.673581057803997,"pubTatorScore":3.214263250113781,"self":"https://pharos.nih.gov/idg/api/v1/targets(7999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/properties"},"_links":{"count":606,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/publications"},"_namespace":null},{"id":8000,"version":2,"created":1554913047000,"modified":1554913047000,"deprecated":false,"name":"Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23","accession":"D6RBM5","gene":"USP17L23","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/properties"},"_links":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/publications"},"_namespace":null}]}
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Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.03152970687826,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.322067,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":0.9074624733672506,"self":"https://pharos.nih.gov/idg/api/v1/targets(8002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/publications"},"_namespace":null},{"id":8003,"version":2,"created":1554913056000,"modified":1554913060000,"deprecated":false,"name":"Lysine-specific demethylase 4D","accession":"Q6B0I6","gene":"KDM4D","description":"Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.5132705064383913,"antibodyCount":162,"monoclonalCount":5,"pubmedCount":null,"jensenScore":28.325295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.65661162481791,"pubTatorScore":1.0731071228027258,"self":"https://pharos.nih.gov/idg/api/v1/targets(8003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/properties"},"_links":{"count":824,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/links"},"_synonyms":{"count":628,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/publications"},"_namespace":null},{"id":8004,"version":2,"created":1554913061000,"modified":1554913061000,"deprecated":false,"name":"TPT1-like protein","accession":"Q56UQ5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/properties"},"_links":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/publications"},"_namespace":null},{"id":8005,"version":2,"created":1554913061000,"modified":1554913065000,"deprecated":false,"name":"5'-3' exoribonuclease 2","accession":"Q9H0D6","gene":"XRN2","description":"Possesses 5'->3' exoribonuclease activity (By similarity). 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Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5279249182741235,"antibodyCount":121,"monoclonalCount":3,"pubmedCount":null,"jensenScore":31.795471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.4794307677141,"pubTatorScore":1.4821459168057405,"self":"https://pharos.nih.gov/idg/api/v1/targets(8005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/publications"},"_namespace":null},{"id":8006,"version":2,"created":1554913066000,"modified":1554913068000,"deprecated":false,"name":"Zinc finger protein 541","accession":"Q9H0D2","gene":"ZNF541","description":"Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":94,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.672968065826032,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(8006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/properties"},"_links":{"count":791,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/publications"},"_namespace":null},{"id":8007,"version":3,"created":1554913069000,"modified":1555037951000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 4 regulatory subunit 4","accession":"Q6NUP7","gene":"PPP4R4","description":"Putative regulatory subunit of serine/threonine-protein phosphatase 4.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.24454863947025823,"antibodyCount":29,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.550505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.425387986720537,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/publications"},"_namespace":null},{"id":8008,"version":2,"created":1554913072000,"modified":1554913075000,"deprecated":false,"name":"3-ketodihydrosphingosine reductase","accession":"Q06136","gene":"KDSR","description":"Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2164591509127096,"antibodyCount":101,"monoclonalCount":30,"pubmedCount":null,"jensenScore":15.308081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.90280472755012,"pubTatorScore":0.9745372983167193,"self":"https://pharos.nih.gov/idg/api/v1/targets(8008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/properties"},"_links":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/publications"},"_namespace":null},{"id":8009,"version":3,"created":1554913076000,"modified":1555037952000,"deprecated":false,"name":"Forkhead box protein P2","accession":"O15409","gene":"FOXP2","description":"Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. 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Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. 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Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.2984691430971314,"antibodyCount":120,"monoclonalCount":7,"pubmedCount":null,"jensenScore":202.13329,"patentCount":24291,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":37.21657856721995,"pubTatorScore":2.1912789142375746,"self":"https://pharos.nih.gov/idg/api/v1/targets(8138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/synonyms"},"_publications":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/publications"},"_namespace":null},{"id":8139,"version":2,"created":1554913576000,"modified":1554913580000,"deprecated":false,"name":"G protein-activated inward rectifier potassium channel 1","accession":"P48549","gene":"KCNJ3","description":"This potassium channel is controlled by G proteins. 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This receptor plays a crucial role in regulating the heartbeat.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.344316157218975,"antibodyCount":267,"monoclonalCount":74,"pubmedCount":null,"jensenScore":217.248882,"patentCount":12933,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.28652707361,"pubTatorScore":2.0574792866840523,"self":"https://pharos.nih.gov/idg/api/v1/targets(8139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/publications"},"_namespace":null},{"id":8140,"version":2,"created":1554913581000,"modified":1554913587000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily C member 1","accession":"P48547","gene":"KCNC1","description":"Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. 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Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.461628632232837,"antibodyCount":308,"monoclonalCount":63,"pubmedCount":null,"jensenScore":275.71541,"patentCount":9049,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.17649349615046,"pubTatorScore":2.034424623231145,"self":"https://pharos.nih.gov/idg/api/v1/targets(8140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/publications"},"_namespace":null},{"id":8141,"version":3,"created":1554913588000,"modified":1555038031000,"deprecated":false,"name":"Splicing factor, proline- and glutamine-rich","accession":"P23246","gene":"SFPQ","description":"DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). 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They alter the interaction of IGFs with their cell surface receptors.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.0786975377492243,"antibodyCount":254,"monoclonalCount":58,"pubmedCount":null,"jensenScore":126.124993,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":35.84224644371663,"pubTatorScore":2.0231799325743745,"self":"https://pharos.nih.gov/idg/api/v1/targets(8143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/publications"},"_namespace":null},{"id":8144,"version":3,"created":1554913599000,"modified":1555038034000,"deprecated":false,"name":"Transcription factor E2F8","accession":"A0AVK6","gene":"E2F8","description":"Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3683129724522838,"antibodyCount":147,"monoclonalCount":22,"pubmedCount":null,"jensenScore":22.745361,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.26869369467345,"pubTatorScore":1.0638474514075371,"self":"https://pharos.nih.gov/idg/api/v1/targets(8144)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/publications"},"_namespace":null},{"id":8145,"version":2,"created":1554913602000,"modified":1554913608000,"deprecated":false,"name":"Insulin-like growth factor-binding protein 5","accession":"P24593","gene":"IGFBP5","description":"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. 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The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.054733837354705,"antibodyCount":255,"monoclonalCount":1,"pubmedCount":null,"jensenScore":106.84077,"patentCount":5661,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.877288821425346,"pubTatorScore":1.7979184598794475,"self":"https://pharos.nih.gov/idg/api/v1/targets(8147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/properties"},"_links":{"count":702,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/publications"},"_namespace":null},{"id":8148,"version":3,"created":1554913621000,"modified":1555038036000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha","accession":"Q06190","gene":"PPP2R3A","description":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2095781638140588,"antibodyCount":167,"monoclonalCount":1,"pubmedCount":null,"jensenScore":14.487672,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":37.730403124706974,"pubTatorScore":1.3520982181968162,"self":"https://pharos.nih.gov/idg/api/v1/targets(8148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/publications"},"_namespace":null},{"id":8149,"version":3,"created":1554913625000,"modified":1555038037000,"deprecated":false,"name":"Interleukin-13","accession":"P35225","gene":"IL13","description":"Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3186140219192226,"antibodyCount":841,"monoclonalCount":372,"pubmedCount":null,"jensenScore":1913.915736,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.74134781491296,"pubTatorScore":3.2723431164977557,"self":"https://pharos.nih.gov/idg/api/v1/targets(8149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/properties"},"_links":{"count":1174,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/synonyms"},"_publications":{"count":582,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/publications"},"_namespace":null},{"id":8150,"version":3,"created":1554913632000,"modified":1555038041000,"deprecated":false,"name":"Lysosome-associated membrane glycoprotein 1","accession":"P11279","gene":"LAMP1","description":"Acts as a receptor for Lassa virus protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9868887924034104,"antibodyCount":959,"monoclonalCount":575,"pubmedCount":null,"jensenScore":817.340423,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":47.07087463135219,"pubTatorScore":2.6706139268087163,"self":"https://pharos.nih.gov/idg/api/v1/targets(8150)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":560,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/properties"},"_links":{"count":1350,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/publications"},"_namespace":null},{"id":8151,"version":3,"created":1554913638000,"modified":1555038043000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 11","accession":"O75078","gene":"ADAM11","description":"Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8315154512203015,"antibodyCount":103,"monoclonalCount":13,"pubmedCount":null,"jensenScore":6.875137,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.31341384333944,"pubTatorScore":1.2900442548201008,"self":"https://pharos.nih.gov/idg/api/v1/targets(8151)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/properties"},"_links":{"count":750,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/publications"},"_namespace":null},{"id":8152,"version":3,"created":1554913642000,"modified":1555038044000,"deprecated":false,"name":"Catenin beta-1","accession":"P35222","gene":"CTNNB1","description":"Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.9994791590638146,"antibodyCount":3058,"monoclonalCount":1037,"pubmedCount":null,"jensenScore":9786.04604,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":69.2903951911649,"pubTatorScore":3.739476917807999,"self":"https://pharos.nih.gov/idg/api/v1/targets(8152)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2690,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/properties"},"_links":{"count":2577,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/synonyms"},"_publications":{"count":2024,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/publications"},"_namespace":null},{"id":8153,"version":2,"created":1554913665000,"modified":1554913669000,"deprecated":false,"name":"Transcriptional repressor CTCFL","accession":"Q8NI51","gene":"CTCFL","description":"Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8063200826099042,"antibodyCount":164,"monoclonalCount":22,"pubmedCount":null,"jensenScore":44.763128,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.258292484185937,"pubTatorScore":2.0774292800225505,"self":"https://pharos.nih.gov/idg/api/v1/targets(8153)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/properties"},"_links":{"count":718,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/links"},"_synonyms":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/publications"},"_namespace":null},{"id":8154,"version":3,"created":1554913670000,"modified":1555038053000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 23","accession":"O75077","gene":"ADAM23","description":"May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3382430477663663,"antibodyCount":193,"monoclonalCount":6,"pubmedCount":null,"jensenScore":20.953658,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.090229757824964,"pubTatorScore":1.3876837299934661,"self":"https://pharos.nih.gov/idg/api/v1/targets(8154)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/publications"},"_namespace":null},{"id":8155,"version":3,"created":1554913674000,"modified":1554913826000,"deprecated":false,"name":"Nitric oxide synthase, inducible","accession":"P35228","gene":"NOS2","description":"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.351337552126681,"antibodyCount":752,"monoclonalCount":136,"pubmedCount":null,"jensenScore":2277.53404,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.781636578959684,"pubTatorScore":3.7354308593345156,"self":"https://pharos.nih.gov/idg/api/v1/targets(8155)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/properties"},"_links":{"count":1925,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/links"},"_synonyms":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/synonyms"},"_publications":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/publications"},"_namespace":null},{"id":8156,"version":2,"created":1554913830000,"modified":1554913832000,"deprecated":false,"name":"Low-density lipoprotein receptor-related protein 3","accession":"O75074","gene":"LRP3","description":"Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9160777649519216,"antibodyCount":125,"monoclonalCount":10,"pubmedCount":null,"jensenScore":7.517297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.107867737915406,"pubTatorScore":0.396357861811999,"self":"https://pharos.nih.gov/idg/api/v1/targets(8156)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/publications"},"_namespace":null},{"id":8157,"version":3,"created":1554913832000,"modified":1555038054000,"deprecated":false,"name":"Polycomb group RING finger protein 2","accession":"P35227","gene":"PCGF2","description":"Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5918516533436717,"antibodyCount":189,"monoclonalCount":26,"pubmedCount":null,"jensenScore":43.843105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":36.45599816765431,"pubTatorScore":1.6098572432321652,"self":"https://pharos.nih.gov/idg/api/v1/targets(8157)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/properties"},"_links":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/publications"},"_namespace":null},{"id":8158,"version":2,"created":1554913835000,"modified":1554913839000,"deprecated":false,"name":"Spectrin beta chain, erythrocytic","accession":"P11277","gene":"SPTB","description":"Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.459820739477726,"antibodyCount":59,"monoclonalCount":44,"pubmedCount":null,"jensenScore":275.05152,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.312552400992686,"pubTatorScore":2.197186268762998,"self":"https://pharos.nih.gov/idg/api/v1/targets(8158)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/publications"},"_namespace":null},{"id":8159,"version":3,"created":1554913840000,"modified":1555038055000,"deprecated":false,"name":"Polycomb complex protein BMI-1","accession":"P35226","gene":"BMI1","description":"Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.61107566975225,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8294)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/properties"},"_links":{"count":583,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/publications"},"_namespace":null},{"id":8295,"version":3,"created":1554915218000,"modified":1555038168000,"deprecated":false,"name":"Regulator of G-protein signaling 7","accession":"P49802","gene":"RGS7","description":"Regulates G protein-coupled receptor signaling cascades. 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Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7287152045762781,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":53.340898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.77098776590116,"pubTatorScore":1.1903316701512918,"self":"https://pharos.nih.gov/idg/api/v1/targets(8346)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/publications"},"_namespace":null},{"id":8347,"version":3,"created":1554916023000,"modified":1555038223000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 5","accession":"Q9H0X9","gene":"OSBPL5","description":"Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). 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Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. 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Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.372851647074892,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(8456)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/properties"},"_links":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/links"},"_synonyms":{"count":831,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/publications"},"_namespace":null},{"id":8457,"version":2,"created":1554917033000,"modified":1554917035000,"deprecated":false,"name":"MutS protein homolog 4","accession":"O15457","gene":"MSH4","description":"Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8506527739700103,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":67.466098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.4118508485133,"pubTatorScore":1.473390363468887,"self":"https://pharos.nih.gov/idg/api/v1/targets(8457)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/publications"},"_namespace":null},{"id":8458,"version":2,"created":1554917036000,"modified":1554917037000,"deprecated":false,"name":"Immunoglobulin heavy constant epsilon","accession":"P01854","gene":"IGHE","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.264043941865783,"pubTatorScore":1.0014452264457927,"self":"https://pharos.nih.gov/idg/api/v1/targets(8458)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/properties"},"_links":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/publications"},"_namespace":null},{"id":8459,"version":3,"created":1554917037000,"modified":1555038315000,"deprecated":false,"name":"Toll-like receptor 3","accession":"O15455","gene":"TLR3","description":"Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.090615155026671,"antibodyCount":874,"monoclonalCount":351,"pubmedCount":null,"jensenScore":1260.402486,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.02481535947711,"pubTatorScore":2.8987585255713544,"self":"https://pharos.nih.gov/idg/api/v1/targets(8459)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/properties"},"_links":{"count":1538,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/synonyms"},"_publications":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/publications"},"_namespace":null},{"id":8460,"version":2,"created":1554917045000,"modified":1554917048000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit C-like protein","accession":"B5ME19","gene":"EIF3CL","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.889968962738322,"pubTatorScore":-0.3429747592865546,"self":"https://pharos.nih.gov/idg/api/v1/targets(8460)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/publications"},"_namespace":null},{"id":8461,"version":2,"created":1554917049000,"modified":1554917049000,"deprecated":false,"name":"T-cell receptor beta-1 chain C region","accession":"P01850","gene":"TRBC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.4243740426214195,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8461)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/links"},"_synonyms":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/publications"},"_namespace":null},{"id":8462,"version":3,"created":1554917049000,"modified":1555038318000,"deprecated":false,"name":"Pterin-4-alpha-carbinolamine dehydratase 2","accession":"Q9H0N5","gene":"PCBD2","description":"Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6520620662636819,"antibodyCount":39,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.666677,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.832539090540465,"pubTatorScore":0.3832166320459405,"self":"https://pharos.nih.gov/idg/api/v1/targets(8462)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/publications"},"_namespace":null},{"id":8463,"version":3,"created":1554917052000,"modified":1555038319000,"deprecated":false,"name":"Ras-related protein Rab-6C","accession":"Q9H0N0","gene":"RAB6C","description":"May be involved in the regulation of centrosome duplication and cell cycle progression.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8574484859173215,"antibodyCount":82,"monoclonalCount":1,"pubmedCount":null,"jensenScore":8.999534,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":21.7748814371019,"pubTatorScore":0.9164539485499251,"self":"https://pharos.nih.gov/idg/api/v1/targets(8463)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/publications"},"_namespace":null},{"id":8464,"version":4,"created":1554917055000,"modified":1555038320000,"deprecated":false,"name":"Tyrosine-protein kinase ABL1","accession":"P00519","gene":"ABL1","description":"Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.5185430385829926,"antibodyCount":1661,"monoclonalCount":101,"pubmedCount":null,"jensenScore":3418.508528,"patentCount":329475,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.116686108180204,"pubTatorScore":3.6638749284355425,"self":"https://pharos.nih.gov/idg/api/v1/targets(8464)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1323,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/properties"},"_links":{"count":2356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/links"},"_synonyms":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/synonyms"},"_publications":{"count":696,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/publications"},"_namespace":null},{"id":8465,"version":3,"created":1554917272000,"modified":1555038326000,"deprecated":false,"name":"T-cell receptor alpha chain C region","accession":"P01848","gene":"TRAC","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":15.843069165144506,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8465)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/properties"},"_links":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/links"},"_synonyms":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/publications"},"_namespace":null},{"id":8466,"version":2,"created":1554917274000,"modified":1554917275000,"deprecated":false,"name":"C-C motif chemokine 16","accession":"O15467","gene":"CCL16","description":"Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4319555894498075,"antibodyCount":267,"monoclonalCount":128,"pubmedCount":null,"jensenScore":263.567976,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.587625224026148,"pubTatorScore":2.1500030177954432,"self":"https://pharos.nih.gov/idg/api/v1/targets(8466)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/properties"},"_links":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/publications"},"_namespace":null},{"id":8467,"version":3,"created":1554917275000,"modified":1555038326000,"deprecated":false,"name":"Alpha-2,8-sialyltransferase 8E","accession":"O15466","gene":"ST8SIA5","description":"May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.577874607822833,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.533333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.945095661519453,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8467)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/publications"},"_namespace":null},{"id":8468,"version":3,"created":1554917278000,"modified":1555038327000,"deprecated":false,"name":"WD repeat and FYVE domain-containing protein 3","accession":"Q8IZQ1","gene":"WDFY3","description":"Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3246048127235512,"antibodyCount":118,"monoclonalCount":7,"pubmedCount":null,"jensenScore":21.989354,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":43.91445225384033,"pubTatorScore":1.1616531352583428,"self":"https://pharos.nih.gov/idg/api/v1/targets(8468)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/publications"},"_namespace":null},{"id":8469,"version":2,"created":1554917283000,"modified":1554917285000,"deprecated":false,"name":"Selenoprotein H","accession":"Q8IZQ5","gene":"SELENOH","description":"May be involved in a redox-related process.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.523025851256227,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.0306128760730422,"self":"https://pharos.nih.gov/idg/api/v1/targets(8469)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/publications"},"_namespace":null},{"id":8470,"version":2,"created":1554917286000,"modified":1554917289000,"deprecated":false,"name":"mRNA decay activator protein ZFP36L1","accession":"Q07352","gene":"ZFP36L1","description":"Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5133920138747357,"antibodyCount":285,"monoclonalCount":26,"pubmedCount":null,"jensenScore":38.648147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.75927551228342,"pubTatorScore":1.441070763718873,"self":"https://pharos.nih.gov/idg/api/v1/targets(8470)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/publications"},"_namespace":null},{"id":8471,"version":2,"created":1554917290000,"modified":1554917294000,"deprecated":false,"name":"Myocardin","accession":"Q8IZQ8","gene":"MYOCD","description":"Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3780078451984834,"antibodyCount":84,"monoclonalCount":7,"pubmedCount":null,"jensenScore":242.669289,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.55341773309332,"pubTatorScore":1.8855646743928407,"self":"https://pharos.nih.gov/idg/api/v1/targets(8471)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/publications"},"_namespace":null},{"id":8472,"version":3,"created":1554917295000,"modified":1555038329000,"deprecated":false,"name":"CASP8 and FADD-like apoptosis regulator","accession":"O15519","gene":"CFLAR","description":"Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8979266406172157,"antibodyCount":683,"monoclonalCount":178,"pubmedCount":null,"jensenScore":871.651564,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":50.84810880552975,"pubTatorScore":3.2975145185297956,"self":"https://pharos.nih.gov/idg/api/v1/targets(8472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":671,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/properties"},"_links":{"count":1348,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/links"},"_synonyms":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/synonyms"},"_publications":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/publications"},"_namespace":null},{"id":8473,"version":2,"created":1554917302000,"modified":1554917305000,"deprecated":false,"name":"Adhesion G-protein coupled receptor G2","accession":"Q8IZP9","gene":"ADGRG2","description":"Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.3461983071692267,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.431229,"patentCount":6961,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.913626987038768,"pubTatorScore":1.12215579398197,"self":"https://pharos.nih.gov/idg/api/v1/targets(8473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/publications"},"_namespace":null},{"id":8474,"version":3,"created":1554917306000,"modified":1555038332000,"deprecated":false,"name":"Actin-related protein 2/3 complex subunit 5","accession":"O15511","gene":"ARPC5","description":"Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0859915002040568,"antibodyCount":94,"monoclonalCount":46,"pubmedCount":null,"jensenScore":11.67095,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":45.78480391100476,"pubTatorScore":0.9208187886959324,"self":"https://pharos.nih.gov/idg/api/v1/targets(8474)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/properties"},"_links":{"count":1089,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/publications"},"_namespace":null},{"id":8475,"version":3,"created":1554917310000,"modified":1555038333000,"deprecated":false,"name":"Circadian locomoter output cycles protein kaput","accession":"O15516","gene":"CLOCK","description":"Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-2.630131335784661,"antibodyCount":323,"monoclonalCount":82,"pubmedCount":null,"jensenScore":392.741826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":51.1304071041192,"pubTatorScore":2.6304543173634345,"self":"https://pharos.nih.gov/idg/api/v1/targets(8475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/properties"},"_links":{"count":1184,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/synonyms"},"_publications":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/publications"},"_namespace":null},{"id":8476,"version":3,"created":1554917316000,"modified":1555038335000,"deprecated":false,"name":"DNA-directed RNA polymerase II subunit RPB4","accession":"O15514","gene":"POLR2D","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5375567629528617,"antibodyCount":136,"monoclonalCount":10,"pubmedCount":null,"jensenScore":3.340078,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":37.13981415160953,"pubTatorScore":0.15126747095672716,"self":"https://pharos.nih.gov/idg/api/v1/targets(8476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/publications"},"_namespace":null},{"id":8477,"version":4,"created":1554917319000,"modified":1555038337000,"deprecated":false,"name":"3-phosphoinositide-dependent protein kinase 1","accession":"O15530","gene":"PDPK1","description":"Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.120250016231711,"antibodyCount":608,"monoclonalCount":75,"pubmedCount":null,"jensenScore":204.919768,"patentCount":86102,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":55.90502628346062,"pubTatorScore":1.725204536593276,"self":"https://pharos.nih.gov/idg/api/v1/targets(8477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":791,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/properties"},"_links":{"count":1462,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/links"},"_synonyms":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/synonyms"},"_publications":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/publications"},"_namespace":null},{"id":8478,"version":2,"created":1554917417000,"modified":1554917421000,"deprecated":false,"name":"Abl interactor 1","accession":"Q8IZP0","gene":"ABI1","description":"May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.999531215057872,"antibodyCount":264,"monoclonalCount":21,"pubmedCount":null,"jensenScore":104.145211,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.04616964727963,"pubTatorScore":1.9905819605584292,"self":"https://pharos.nih.gov/idg/api/v1/targets(8478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/properties"},"_links":{"count":1501,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/links"},"_synonyms":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/publications"},"_namespace":null},{"id":8479,"version":2,"created":1554917423000,"modified":1554917423000,"deprecated":false,"name":"TBC1 domain family member 3","accession":"Q8IZP1","gene":"TBC1D3","description":"Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.010318771372505,"pubTatorScore":0.9558480201291164,"self":"https://pharos.nih.gov/idg/api/v1/targets(8479)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/publications"},"_namespace":null},{"id":8480,"version":2,"created":1554917424000,"modified":1554917424000,"deprecated":false,"name":"Putative protein FAM10A4","accession":"Q8IZP2","gene":"ST13P4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.7468435541413623,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":82.306432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.0816072578258,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8480)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/properties"},"_links":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/publications"},"_namespace":null},{"id":8481,"version":3,"created":1554917424000,"modified":1554917650000,"deprecated":false,"name":"cAMP-specific 3',5'-cyclic phosphodiesterase 4B","accession":"Q07343","gene":"PDE4B","description":"Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. 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Is also active with 25-hydroxy-24-oxo-vitamin D3. 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The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.864493348308136,"antibodyCount":178,"monoclonalCount":13,"pubmedCount":null,"jensenScore":71.376263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":47.152705171396704,"pubTatorScore":3.214249644397373,"self":"https://pharos.nih.gov/idg/api/v1/targets(8505)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/synonyms"},"_publications":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/publications"},"_namespace":null},{"id":8506,"version":2,"created":1554917881000,"modified":1554917884000,"deprecated":false,"name":"Retinoschisin","accession":"O15537","gene":"RS1","description":"Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1082830635994663,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":131.269091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.10124985755508,"pubTatorScore":2.609422034806526,"self":"https://pharos.nih.gov/idg/api/v1/targets(8506)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/properties"},"_links":{"count":702,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/publications"},"_namespace":null},{"id":8507,"version":2,"created":1554917884000,"modified":1554917887000,"deprecated":false,"name":"Zinc finger and SCAN domain-containing protein 9","accession":"O15535","gene":"ZSCAN9","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.06214790530119616,"antibodyCount":119,"monoclonalCount":12,"pubmedCount":null,"jensenScore":0.845238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.335064004754642,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/publications"},"_namespace":null},{"id":8508,"version":2,"created":1554917887000,"modified":1554917890000,"deprecated":false,"name":"Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase","accession":"P46087","gene":"NOP2","description":"Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.500266604268691,"antibodyCount":69,"monoclonalCount":2,"pubmedCount":null,"jensenScore":29.532846,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.82066748503302,"pubTatorScore":1.49934928732378,"self":"https://pharos.nih.gov/idg/api/v1/targets(8508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/properties"},"_links":{"count":1048,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/publications"},"_namespace":null},{"id":8509,"version":2,"created":1554917891000,"modified":1554917894000,"deprecated":false,"name":"Claudin-3","accession":"O15551","gene":"CLDN3","description":"Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.376805516887729,"antibodyCount":358,"monoclonalCount":48,"pubmedCount":null,"jensenScore":227.318425,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.71555335613557,"pubTatorScore":2.0379002141423874,"self":"https://pharos.nih.gov/idg/api/v1/targets(8509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/publications"},"_namespace":null},{"id":8510,"version":2,"created":1554917895000,"modified":1554917895000,"deprecated":false,"name":"Olfactory receptor 2AJ1","accession":"Q8NGZ0","gene":"OR2AJ1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":89,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2723321439053135,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/properties"},"_links":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/publications"},"_namespace":null},{"id":8511,"version":2,"created":1554917896000,"modified":1554917900000,"deprecated":false,"name":"Free fatty acid receptor 2","accession":"O15552","gene":"FFAR2","description":"G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.126173887682798,"antibodyCount":221,"monoclonalCount":3,"pubmedCount":null,"jensenScore":144.582927,"patentCount":9122,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.079185205442453,"pubTatorScore":1.7815416707324592,"self":"https://pharos.nih.gov/idg/api/v1/targets(8511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/publications"},"_namespace":null},{"id":8512,"version":3,"created":1554917901000,"modified":1555038358000,"deprecated":false,"name":"G-protein coupled receptor 3","accession":"P46089","gene":"GPR3","description":"Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). 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PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.","idgFamily":"Transporter","idgTDL":"Tclin","novelty":-2.3261675089068423,"antibodyCount":200,"monoclonalCount":7,"pubmedCount":null,"jensenScore":211.247666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":27.477056516095512,"pubTatorScore":2.268280614722028,"self":"https://pharos.nih.gov/idg/api/v1/targets(8561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/properties"},"_links":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/links"},"_synonyms":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/publications"},"_namespace":null},{"id":8562,"version":3,"created":1554918020000,"modified":1555038378000,"deprecated":false,"name":"Small G protein signaling modulator 1","accession":"Q2NKQ1","gene":"SGSM1","description":"Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.9621732590657062,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":230.691813,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.56265029831047,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/properties"},"_links":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/publications"},"_namespace":null},{"id":8566,"version":2,"created":1554918029000,"modified":1554918032000,"deprecated":false,"name":"Nucleoporin-like protein 2","accession":"O15504","gene":"NUPL2","description":"Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. 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They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects (PubMed:20525224). Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity (PubMed:16580639).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-3.253124593346194,"antibodyCount":392,"monoclonalCount":15,"pubmedCount":null,"jensenScore":1716.825855,"patentCount":90709,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":44.0909135873519,"pubTatorScore":3.104341856491005,"self":"https://pharos.nih.gov/idg/api/v1/targets(8617)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/properties"},"_links":{"count":2812,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/links"},"_synonyms":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/synonyms"},"_publications":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/publications"},"_namespace":null},{"id":8618,"version":2,"created":1554919072000,"modified":1554919073000,"deprecated":false,"name":"Olfactory receptor 5B3","accession":"Q8NH48","gene":"OR5B3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":29,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":145,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.909099291461284,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(8618)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/properties"},"_links":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/publications"},"_namespace":null},{"id":8619,"version":2,"created":1554919073000,"modified":1554919079000,"deprecated":false,"name":"Proliferation marker protein Ki-67","accession":"P46013","gene":"MKI67","description":"Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5010598311438956,"antibodyCount":1434,"monoclonalCount":866,"pubmedCount":null,"jensenScore":270.347083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.00752057152913,"pubTatorScore":2.3258841400989714,"self":"https://pharos.nih.gov/idg/api/v1/targets(8619)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/properties"},"_links":{"count":1605,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/synonyms"},"_publications":{"count":643,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/publications"},"_namespace":null},{"id":8620,"version":2,"created":1554919081000,"modified":1554919085000,"deprecated":false,"name":"Phosphorylase b kinase regulatory subunit alpha, liver isoform","accession":"P46019","gene":"PHKA2","description":"Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. 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Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-4.068338760315519,"antibodyCount":731,"monoclonalCount":194,"pubmedCount":null,"jensenScore":12504.507703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.13367853500597,"pubTatorScore":3.8451523457642045,"self":"https://pharos.nih.gov/idg/api/v1/targets(8622)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2532,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/properties"},"_links":{"count":4751,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/links"},"_synonyms":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/synonyms"},"_publications":{"count":2002,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/publications"},"_namespace":null},{"id":8623,"version":3,"created":1554919618000,"modified":1555038402000,"deprecated":false,"name":"Shugoshin 2","accession":"Q562F6","gene":"SGO2","description":"Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.319709006318296,"antibodyCount":90,"monoclonalCount":0,"pubmedCount":null,"jensenScore":22.256813,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":0.0,"pubTatorScore":0.9555808227954455,"self":"https://pharos.nih.gov/idg/api/v1/targets(8623)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/publications"},"_namespace":null},{"id":8624,"version":2,"created":1554919622000,"modified":1554919623000,"deprecated":false,"name":"Olfactory receptor 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May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.8826425170455208,"antibodyCount":847,"monoclonalCount":416,"pubmedCount":null,"jensenScore":722.968733,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":54.05158635149615,"pubTatorScore":2.7847948057750074,"self":"https://pharos.nih.gov/idg/api/v1/targets(8628)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":760,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/properties"},"_links":{"count":1413,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/links"},"_synonyms":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/synonyms"},"_publications":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/publications"},"_namespace":null},{"id":8629,"version":3,"created":1554919655000,"modified":1554919712000,"deprecated":false,"name":"DNA topoisomerase 1","accession":"P11387","gene":"TOP1","description":"Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.6170109380355404,"antibodyCount":248,"monoclonalCount":73,"pubmedCount":null,"jensenScore":4015.403635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.24496818732609,"pubTatorScore":2.688272165258963,"self":"https://pharos.nih.gov/idg/api/v1/targets(8629)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/properties"},"_links":{"count":1560,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/links"},"_synonyms":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/synonyms"},"_publications":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/publications"},"_namespace":null},{"id":8630,"version":2,"created":1554919714000,"modified":1554919714000,"deprecated":false,"name":"Olfactory receptor 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Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7325185071127396,"antibodyCount":128,"monoclonalCount":19,"pubmedCount":null,"jensenScore":534.691006,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.49792866498531,"pubTatorScore":2.907066192265858,"self":"https://pharos.nih.gov/idg/api/v1/targets(8724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/publications"},"_namespace":null},{"id":8725,"version":2,"created":1554920221000,"modified":1554920222000,"deprecated":false,"name":"Olfactory receptor 9G1","accession":"Q8NH87","gene":"OR9G1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":44,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":163,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.042794664382434,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/properties"},"_links":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/publications"},"_namespace":null},{"id":8726,"version":3,"created":1554920222000,"modified":1555038433000,"deprecated":false,"name":"Mucolipin-2","accession":"Q8IZK6","gene":"MCOLN2","description":"Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. 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Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.0689681909272863,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.804666,"patentCount":809,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":23.9148623732212,"pubTatorScore":0.9991603490540104,"self":"https://pharos.nih.gov/idg/api/v1/targets(8726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/publications"},"_namespace":null},{"id":8727,"version":2,"created":1554920227000,"modified":1554920229000,"deprecated":false,"name":"Cytochrome c oxidase assembly protein COX19","accession":"Q49B96","gene":"COX19","description":"May be required for the assembly of mitochondrial cytochrome c oxidase.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.956612215296344,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.304503,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.326493807593366,"pubTatorScore":0.6897034526043669,"self":"https://pharos.nih.gov/idg/api/v1/targets(8727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/publications"},"_namespace":null},{"id":8728,"version":3,"created":1554920230000,"modified":1555038435000,"deprecated":false,"name":"Solute carrier family 15 member 1","accession":"P46059","gene":"SLC15A1","description":"Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. 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Known to play a role, in vitro, in the folding of actin and tubulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4952028935480806,"antibodyCount":212,"monoclonalCount":21,"pubmedCount":null,"jensenScore":31.81788,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.2343072963048,"pubTatorScore":1.2797682980126273,"self":"https://pharos.nih.gov/idg/api/v1/targets(8729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/properties"},"_links":{"count":1193,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/publications"},"_namespace":null},{"id":8730,"version":2,"created":1554920239000,"modified":1554920243000,"deprecated":false,"name":"Alpha-(1,3)-fucosyltransferase 4","accession":"P22083","gene":"FUT4","description":"May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.112309573330625,"antibodyCount":1016,"monoclonalCount":891,"pubmedCount":null,"jensenScore":1234.949611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.234259576947004,"pubTatorScore":2.9371557189822957,"self":"https://pharos.nih.gov/idg/api/v1/targets(8730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/publications"},"_namespace":null},{"id":8731,"version":2,"created":1554920244000,"modified":1554920248000,"deprecated":false,"name":"T-complex protein 1 subunit delta","accession":"P50991","gene":"CCT4","description":"Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7789192405167091,"antibodyCount":177,"monoclonalCount":33,"pubmedCount":null,"jensenScore":58.840048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.29289286467881,"pubTatorScore":2.5353169724476516,"self":"https://pharos.nih.gov/idg/api/v1/targets(8731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/publications"},"_namespace":null},{"id":8732,"version":2,"created":1554920249000,"modified":1554920252000,"deprecated":false,"name":"Galactoside 2-alpha-L-fucosyltransferase 2","accession":"Q10981","gene":"FUT2","description":"Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.060615549346118,"antibodyCount":105,"monoclonalCount":38,"pubmedCount":null,"jensenScore":1122.915903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.93288727560294,"pubTatorScore":2.7225873871965582,"self":"https://pharos.nih.gov/idg/api/v1/targets(8732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/publications"},"_namespace":null},{"id":8733,"version":3,"created":1554920253000,"modified":1555038438000,"deprecated":false,"name":"rRNA 2'-O-methyltransferase fibrillarin","accession":"P22087","gene":"FBL","description":"S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.2733787293766614,"antibodyCount":248,"monoclonalCount":65,"pubmedCount":null,"jensenScore":1797.801806,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":42.256600205729654,"pubTatorScore":1.8796779487284707,"self":"https://pharos.nih.gov/idg/api/v1/targets(8733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/publications"},"_namespace":null},{"id":8734,"version":2,"created":1554920258000,"modified":1554920259000,"deprecated":false,"name":"Olfactory receptor 6B3","accession":"Q8NGW1","gene":"OR6B3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":17,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.2,"patentCount":113,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.098320327421405,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/properties"},"_links":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/publications"},"_namespace":null},{"id":8735,"version":2,"created":1554920259000,"modified":1554920260000,"deprecated":false,"name":"Olfactory receptor 10G6","accession":"Q8NH81","gene":"OR10G6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.089818941454712,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/properties"},"_links":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/publications"},"_namespace":null},{"id":8736,"version":3,"created":1554920260000,"modified":1555038439000,"deprecated":false,"name":"Protein Jade-1","accession":"Q6IE81","gene":"JADE1","description":"Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.0335933580114582,"antibodyCount":135,"monoclonalCount":4,"pubmedCount":null,"jensenScore":13.270421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.959833753220465,"pubTatorScore":0.9968645681237569,"self":"https://pharos.nih.gov/idg/api/v1/targets(8736)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/publications"},"_namespace":null},{"id":8737,"version":3,"created":1554920264000,"modified":1555038441000,"deprecated":false,"name":"Ret finger protein-like 4B","accession":"Q6ZWI9","gene":"RFPL4B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":8.103333623503636,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8737)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/properties"},"_links":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/publications"},"_namespace":null},{"id":8738,"version":3,"created":1554920265000,"modified":1555038442000,"deprecated":false,"name":"Phosphatase and actin regulator 2","accession":"O75167","gene":"PHACTR2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.47952732803227915,"antibodyCount":83,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.67017846365449,"pubTatorScore":0.6197886888012714,"self":"https://pharos.nih.gov/idg/api/v1/targets(8738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/publications"},"_namespace":null},{"id":8739,"version":3,"created":1554920270000,"modified":1555038444000,"deprecated":false,"name":"Nuclear receptor ROR-alpha","accession":"P35398","gene":"RORA","description":"Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. 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Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5772214488283978,"antibodyCount":44,"monoclonalCount":4,"pubmedCount":null,"jensenScore":368.839512,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.00365230918314,"pubTatorScore":1.2595477475776362,"self":"https://pharos.nih.gov/idg/api/v1/targets(8954)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/properties"},"_links":{"count":513,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/publications"},"_namespace":null},{"id":8955,"version":3,"created":1554921710000,"modified":1555038587000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DQ beta 1 chain","accession":"P01920","gene":"HLA-DQB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. 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The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.4109523001913002,"antibodyCount":301,"monoclonalCount":34,"pubmedCount":null,"jensenScore":180.294791,"patentCount":6104,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.952162287922995,"pubTatorScore":1.448976085984794,"self":"https://pharos.nih.gov/idg/api/v1/targets(8962)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/properties"},"_links":{"count":1186,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/publications"},"_namespace":null},{"id":8963,"version":2,"created":1554921934000,"modified":1554921939000,"deprecated":false,"name":"Pyrin","accession":"O15553","gene":"MEFV","description":"Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. 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