{"id":327295,"version":1,"created":1584652354055,"modified":1584652354059,"deprecated":false,"etag":"8076e1ec83a43ee3","uri":"https://pharos.nih.gov/idg/api/v1/targets?top=1000&skip=8000","path":"/idg/api/v1/targets","method":"GET","sha1":"97018d676813cb41bf1f03d84edfcc589327cc0f","total":20244,"count":1000,"skip":8000,"top":1000,"status":null,"query":"skip=8000&top=1000","filter":null,"_namespace":null,"content":[{"id":8001,"version":2,"created":1554913047000,"modified":1554913050000,"deprecated":false,"name":"Histone deacetylase complex subunit SAP130","accession":"Q9H0E3","gene":"SAP130","description":"Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":120,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.043090595724095,"pubTatorScore":0.40842823187220934,"self":"https://pharos.nih.gov/idg/api/v1/targets(8001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(8001)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(8001)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8001)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8001)/publications"},"_namespace":null},{"id":8002,"version":3,"created":1554913051000,"modified":1555037950000,"deprecated":false,"name":"Shootin-1","accession":"A0MZ66","gene":"SHTN1","description":"Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.03152970687826,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.322067,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":0.9074624733672506,"self":"https://pharos.nih.gov/idg/api/v1/targets(8002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8002)/publications"},"_namespace":null},{"id":8003,"version":2,"created":1554913056000,"modified":1554913060000,"deprecated":false,"name":"Lysine-specific demethylase 4D","accession":"Q6B0I6","gene":"KDM4D","description":"Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.5132705064383913,"antibodyCount":162,"monoclonalCount":5,"pubmedCount":null,"jensenScore":28.325295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.65661162481791,"pubTatorScore":1.0731071228027258,"self":"https://pharos.nih.gov/idg/api/v1/targets(8003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/properties"},"_links":{"count":824,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/links"},"_synonyms":{"count":628,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8003)/publications"},"_namespace":null},{"id":8004,"version":2,"created":1554913061000,"modified":1554913061000,"deprecated":false,"name":"TPT1-like protein","accession":"Q56UQ5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/properties"},"_links":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8004)/publications"},"_namespace":null},{"id":8005,"version":2,"created":1554913061000,"modified":1554913065000,"deprecated":false,"name":"5'-3' exoribonuclease 2","accession":"Q9H0D6","gene":"XRN2","description":"Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5279249182741235,"antibodyCount":121,"monoclonalCount":3,"pubmedCount":null,"jensenScore":31.795471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.4794307677141,"pubTatorScore":1.4821459168057405,"self":"https://pharos.nih.gov/idg/api/v1/targets(8005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8005)/publications"},"_namespace":null},{"id":8006,"version":2,"created":1554913066000,"modified":1554913068000,"deprecated":false,"name":"Zinc finger protein 541","accession":"Q9H0D2","gene":"ZNF541","description":"Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":94,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.672968065826032,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(8006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/properties"},"_links":{"count":791,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8006)/publications"},"_namespace":null},{"id":8007,"version":3,"created":1554913069000,"modified":1555037951000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 4 regulatory subunit 4","accession":"Q6NUP7","gene":"PPP4R4","description":"Putative regulatory subunit of serine/threonine-protein phosphatase 4.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.24454863947025823,"antibodyCount":29,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.550505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.425387986720537,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8007)/publications"},"_namespace":null},{"id":8008,"version":2,"created":1554913072000,"modified":1554913075000,"deprecated":false,"name":"3-ketodihydrosphingosine reductase","accession":"Q06136","gene":"KDSR","description":"Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2164591509127096,"antibodyCount":101,"monoclonalCount":30,"pubmedCount":null,"jensenScore":15.308081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.90280472755012,"pubTatorScore":0.9745372983167193,"self":"https://pharos.nih.gov/idg/api/v1/targets(8008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/properties"},"_links":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8008)/publications"},"_namespace":null},{"id":8009,"version":3,"created":1554913076000,"modified":1555037952000,"deprecated":false,"name":"Forkhead box protein P2","accession":"O15409","gene":"FOXP2","description":"Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.526442964545155,"antibodyCount":340,"monoclonalCount":71,"pubmedCount":null,"jensenScore":311.393366,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":40.81919334370983,"pubTatorScore":2.380267202378742,"self":"https://pharos.nih.gov/idg/api/v1/targets(8009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(8009)/properties"},"_links":{"count":1046,"href":"https://pharos.nih.gov/idg/api/v1/targets(8009)/links"},"_synonyms":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(8009)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8009)/publications"},"_namespace":null},{"id":8010,"version":2,"created":1554913081000,"modified":1554913084000,"deprecated":false,"name":"Integrin-linked kinase-associated serine/threonine phosphatase 2C","accession":"Q9H0C8","gene":"ILKAP","description":"Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7885216471011202,"antibodyCount":232,"monoclonalCount":12,"pubmedCount":null,"jensenScore":7.399855,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.86170610586088,"pubTatorScore":0.9274681452912605,"self":"https://pharos.nih.gov/idg/api/v1/targets(8010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(8010)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(8010)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8010)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8010)/publications"},"_namespace":null},{"id":8011,"version":3,"created":1554913085000,"modified":1555037955000,"deprecated":false,"name":"Syntaxin-7","accession":"O15400","gene":"STX7","description":"May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2865846459214074,"antibodyCount":108,"monoclonalCount":8,"pubmedCount":null,"jensenScore":20.517297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":44.978037717819475,"pubTatorScore":1.3625190602582768,"self":"https://pharos.nih.gov/idg/api/v1/targets(8011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(8011)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(8011)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8011)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8011)/publications"},"_namespace":null},{"id":8012,"version":2,"created":1554913090000,"modified":1554913092000,"deprecated":false,"name":"TOX high mobility group box family member 3","accession":"O15405","gene":"TOX3","description":"Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6448087130549565,"antibodyCount":156,"monoclonalCount":65,"pubmedCount":null,"jensenScore":43.273509,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.83017952784952,"pubTatorScore":1.7184888259205273,"self":"https://pharos.nih.gov/idg/api/v1/targets(8012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(8012)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(8012)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8012)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8012)/publications"},"_namespace":null},{"id":8013,"version":2,"created":1554913094000,"modified":1554913096000,"deprecated":false,"name":"Transmembrane protein 117","accession":"Q9H0C3","gene":"TMEM117","description":"Involved in endoplasmic reticulum (ER) stress-induced cell death pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.12493873660829995,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.205399046494016,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(8013)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(8013)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8013)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8013)/publications"},"_namespace":null},{"id":8014,"version":2,"created":1554913097000,"modified":1554913100000,"deprecated":false,"name":"Monocarboxylate transporter 7","accession":"O15403","gene":"SLC16A6","description":"Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.7413699236553952,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.994646,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.662466731164606,"pubTatorScore":0.7146453888497183,"self":"https://pharos.nih.gov/idg/api/v1/targets(8014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(8014)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(8014)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8014)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8014)/publications"},"_namespace":null},{"id":8015,"version":3,"created":1554913101000,"modified":1555037956000,"deprecated":false,"name":"BTB/POZ domain-containing protein 1","accession":"Q9H0C5","gene":"BTBD1","description":"Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4051185965563696,"antibodyCount":134,"monoclonalCount":20,"pubmedCount":null,"jensenScore":3.85185,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":37.880551912809175,"pubTatorScore":0.33579216873772366,"self":"https://pharos.nih.gov/idg/api/v1/targets(8015)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(8015)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(8015)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8015)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8015)/publications"},"_namespace":null},{"id":8016,"version":2,"created":1554913105000,"modified":1554913106000,"deprecated":false,"name":"ADP/ATP translocase 4","accession":"Q9H0C2","gene":"SLC25A31","description":"Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.462647550048566,"antibodyCount":121,"monoclonalCount":2,"pubmedCount":null,"jensenScore":29.853119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.45287795476088,"pubTatorScore":1.3297367612486248,"self":"https://pharos.nih.gov/idg/api/v1/targets(8016)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(8016)/properties"},"_links":{"count":611,"href":"https://pharos.nih.gov/idg/api/v1/targets(8016)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8016)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8016)/publications"},"_namespace":null},{"id":8017,"version":2,"created":1554913107000,"modified":1554913107000,"deprecated":false,"name":"S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase","accession":"Q6NUM6","gene":"TYW1B","description":"Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.565726074745978,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8017)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8017)/properties"},"_links":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8017)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8017)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8017)/publications"},"_namespace":null},{"id":8018,"version":2,"created":1554913107000,"modified":1554913109000,"deprecated":false,"name":"Zinc finger MYND domain-containing protein 12","accession":"Q9H0C1","gene":"ZMYND12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":40,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.114592448328015,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8018)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(8018)/properties"},"_links":{"count":719,"href":"https://pharos.nih.gov/idg/api/v1/targets(8018)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8018)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8018)/publications"},"_namespace":null},{"id":8019,"version":3,"created":1554913110000,"modified":1555037958000,"deprecated":false,"name":"Tyrosine-protein phosphatase non-receptor type 11","accession":"Q06124","gene":"PTPN11","description":"Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.1103230051091306,"antibodyCount":1077,"monoclonalCount":149,"pubmedCount":null,"jensenScore":1400.005258,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":63.140978290775855,"pubTatorScore":2.981815315305645,"self":"https://pharos.nih.gov/idg/api/v1/targets(8019)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1268,"href":"https://pharos.nih.gov/idg/api/v1/targets(8019)/properties"},"_links":{"count":1726,"href":"https://pharos.nih.gov/idg/api/v1/targets(8019)/links"},"_synonyms":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(8019)/synonyms"},"_publications":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(8019)/publications"},"_namespace":null},{"id":8020,"version":2,"created":1554913130000,"modified":1554913133000,"deprecated":false,"name":"All-trans-retinol 13,14-reductase","accession":"Q6NUM9","gene":"RETSAT","description":"Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7691838463433324,"antibodyCount":14,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.45804,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.72604776204284,"pubTatorScore":0.34406456233529403,"self":"https://pharos.nih.gov/idg/api/v1/targets(8020)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(8020)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8020)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8020)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8020)/publications"},"_namespace":null},{"id":8021,"version":2,"created":1554913134000,"modified":1554913137000,"deprecated":false,"name":"Ubiquitin-like modifier-activating enzyme 6","accession":"A0AVT1","gene":"UBA6","description":"Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-0.8404446567913337,"antibodyCount":173,"monoclonalCount":21,"pubmedCount":null,"jensenScore":8.007829,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.02548855488632,"pubTatorScore":1.0272686542634482,"self":"https://pharos.nih.gov/idg/api/v1/targets(8021)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(8021)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(8021)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8021)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8021)/publications"},"_namespace":null},{"id":8022,"version":3,"created":1554913138000,"modified":1555037963000,"deprecated":false,"name":"Kinesin light chain 2","accession":"Q9H0B6","gene":"KLC2","description":"Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7184159964284208,"antibodyCount":153,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.050681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.76129817042663,"pubTatorScore":0.8325089127062363,"self":"https://pharos.nih.gov/idg/api/v1/targets(8022)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(8022)/properties"},"_links":{"count":1182,"href":"https://pharos.nih.gov/idg/api/v1/targets(8022)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8022)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8022)/publications"},"_namespace":null},{"id":8023,"version":2,"created":1554913142000,"modified":1554913146000,"deprecated":false,"name":"Cysteine-rich secretory protein LCCL domain-containing 2","accession":"Q9H0B8","gene":"CRISPLD2","description":"Promotes matrix assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1346022501678892,"antibodyCount":88,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.407058,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.10978489614966,"pubTatorScore":2.397748322643908,"self":"https://pharos.nih.gov/idg/api/v1/targets(8023)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(8023)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(8023)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8023)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8023)/publications"},"_namespace":null},{"id":8024,"version":3,"created":1554913146000,"modified":1555037966000,"deprecated":false,"name":"IQ domain-containing protein N","accession":"Q9H0B3","gene":"IQCN","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8024)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(8024)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(8024)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8024)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8024)/publications"},"_namespace":null},{"id":8025,"version":2,"created":1554913150000,"modified":1554913152000,"deprecated":false,"name":"Trinucleotide repeat-containing gene 18 protein","accession":"O15417","gene":"TNRC18","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.99513606880727,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8025)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(8025)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(8025)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8025)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8025)/publications"},"_namespace":null},{"id":8026,"version":2,"created":1554913153000,"modified":1554913157000,"deprecated":false,"name":"Zinc finger protein 746","accession":"Q6NUN9","gene":"ZNF746","description":"Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.5312300143036555,"antibodyCount":34,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.943232,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.76265053053374,"pubTatorScore":1.3492775274679554,"self":"https://pharos.nih.gov/idg/api/v1/targets(8026)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(8026)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(8026)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8026)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8026)/publications"},"_namespace":null},{"id":8027,"version":2,"created":1554913158000,"modified":1554913161000,"deprecated":false,"name":"Jhy protein homolog","accession":"Q6NUN7","gene":"JHY","description":"Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8027)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(8027)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(8027)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8027)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8027)/publications"},"_namespace":null},{"id":8028,"version":2,"created":1554913162000,"modified":1554913166000,"deprecated":false,"name":"High affinity copper uptake protein 1","accession":"O15431","gene":"SLC31A1","description":"High-affinity, saturable copper transporter involved in dietary copper uptake.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.98628074667955,"antibodyCount":136,"monoclonalCount":36,"pubmedCount":null,"jensenScore":95.608904,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.0236710035521,"pubTatorScore":2.268686595096698,"self":"https://pharos.nih.gov/idg/api/v1/targets(8028)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(8028)/properties"},"_links":{"count":980,"href":"https://pharos.nih.gov/idg/api/v1/targets(8028)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8028)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8028)/publications"},"_namespace":null},{"id":8029,"version":2,"created":1554913167000,"modified":1554913169000,"deprecated":false,"name":"NKG2-E type II integral membrane protein","accession":"Q07444","gene":"KLRC3","description":"Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0046002217112089,"antibodyCount":42,"monoclonalCount":16,"pubmedCount":null,"jensenScore":5.84685,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.00610213721957,"pubTatorScore":0.8943772695194538,"self":"https://pharos.nih.gov/idg/api/v1/targets(8029)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(8029)/properties"},"_links":{"count":662,"href":"https://pharos.nih.gov/idg/api/v1/targets(8029)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8029)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8029)/publications"},"_namespace":null},{"id":8030,"version":2,"created":1554913169000,"modified":1554913171000,"deprecated":false,"name":"Speriolin-like protein","accession":"Q9H0A9","gene":"SPATC1L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.00729923765576327,"antibodyCount":130,"monoclonalCount":11,"pubmedCount":null,"jensenScore":1.253846,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.831629387559566,"pubTatorScore":-0.22847939532991027,"self":"https://pharos.nih.gov/idg/api/v1/targets(8030)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(8030)/properties"},"_links":{"count":838,"href":"https://pharos.nih.gov/idg/api/v1/targets(8030)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8030)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8030)/publications"},"_namespace":null},{"id":8031,"version":2,"created":1554913172000,"modified":1554913175000,"deprecated":false,"name":"RING finger protein 32","accession":"Q9H0A6","gene":"RNF32","description":"May play a role in sperm formation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5051499783199059,"antibodyCount":62,"monoclonalCount":4,"pubmedCount":null,"jensenScore":2.098947,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.095024010573372,"pubTatorScore":0.42777456917657786,"self":"https://pharos.nih.gov/idg/api/v1/targets(8031)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8031)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(8031)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8031)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8031)/publications"},"_namespace":null},{"id":8032,"version":3,"created":1554913175000,"modified":1555037967000,"deprecated":false,"name":"Acyl-coenzyme A synthetase ACSM5, mitochondrial","accession":"Q6NUN0","gene":"ACSM5","description":"Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5310224841682272,"antibodyCount":45,"monoclonalCount":16,"pubmedCount":null,"jensenScore":2.242266,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":24.98745091151484,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8032)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(8032)/properties"},"_links":{"count":791,"href":"https://pharos.nih.gov/idg/api/v1/targets(8032)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8032)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8032)/publications"},"_namespace":null},{"id":8033,"version":3,"created":1554913178000,"modified":1555037968000,"deprecated":false,"name":"COMM domain-containing protein 4","accession":"Q9H0A8","gene":"COMMD4","description":"May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.018405064525185533,"antibodyCount":69,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.073413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":31.983376078173162,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8033)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(8033)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(8033)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8033)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8033)/publications"},"_namespace":null},{"id":8034,"version":3,"created":1554913182000,"modified":1555037969000,"deprecated":false,"name":"Monocarboxylate transporter 4","accession":"O15427","gene":"SLC16A3","description":"Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.3314773859403235,"antibodyCount":161,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.86411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.01214127136202,"pubTatorScore":1.8851502419164674,"self":"https://pharos.nih.gov/idg/api/v1/targets(8034)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(8034)/properties"},"_links":{"count":1183,"href":"https://pharos.nih.gov/idg/api/v1/targets(8034)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8034)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8034)/publications"},"_namespace":null},{"id":8035,"version":2,"created":1554913188000,"modified":1554913189000,"deprecated":false,"name":"Putative PIN1-like protein","accession":"O15428","gene":"PIN1P1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.444216549914224,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":522.829091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.586209327733476,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8035)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8035)/properties"},"_links":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(8035)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8035)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8035)/publications"},"_namespace":null},{"id":8036,"version":2,"created":1554913189000,"modified":1554913192000,"deprecated":false,"name":"Polyadenylate-binding protein 1-like","accession":"Q4VXU2","gene":"PABPC1L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.2279172943541936,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.310644,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.84367865703267,"pubTatorScore":0.8071114859588188,"self":"https://pharos.nih.gov/idg/api/v1/targets(8036)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(8036)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(8036)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8036)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8036)/publications"},"_namespace":null},{"id":8037,"version":2,"created":1554913192000,"modified":1554913193000,"deprecated":false,"name":"Transmembrane protein 191A","accession":"Q9H0A3","gene":"TMEM191A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.56875426169627,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8037)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8037)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8037)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8037)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8037)/publications"},"_namespace":null},{"id":8038,"version":2,"created":1554913193000,"modified":1554913196000,"deprecated":false,"name":"Enkurin domain-containing protein 1","accession":"Q9H0I2","gene":"ENKD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":87,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.974296103369085,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(8038)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(8038)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8038)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8038)/publications"},"_namespace":null},{"id":8039,"version":3,"created":1554913196000,"modified":1555037971000,"deprecated":false,"name":"Coiled-coil domain-containing protein 113","accession":"Q9H0I3","gene":"CCDC113","description":"Component of centriolar satellites contributing to primary cilium formation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.51299220244442,"pubTatorScore":-0.6478174818886375,"self":"https://pharos.nih.gov/idg/api/v1/targets(8039)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(8039)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(8039)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8039)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8039)/publications"},"_namespace":null},{"id":8040,"version":2,"created":1554913200000,"modified":1554913201000,"deprecated":false,"name":"UDP-glucuronosyltransferase 3A1","accession":"Q6NUS8","gene":"UGT3A1","description":"UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.3562410565135148,"antibodyCount":37,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.985098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.825449448973846,"pubTatorScore":0.6410960701545727,"self":"https://pharos.nih.gov/idg/api/v1/targets(8040)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(8040)/properties"},"_links":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(8040)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8040)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8040)/publications"},"_namespace":null},{"id":8041,"version":2,"created":1554913202000,"modified":1554913204000,"deprecated":false,"name":"Ectonucleoside triphosphate diphosphohydrolase 8","accession":"Q5MY95","gene":"ENTPD8","description":"Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6454304159213904,"antibodyCount":116,"monoclonalCount":2,"pubmedCount":null,"jensenScore":43.477452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.992370093794296,"pubTatorScore":1.2197341722429305,"self":"https://pharos.nih.gov/idg/api/v1/targets(8041)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(8041)/properties"},"_links":{"count":756,"href":"https://pharos.nih.gov/idg/api/v1/targets(8041)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8041)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8041)/publications"},"_namespace":null},{"id":8042,"version":2,"created":1554913204000,"modified":1554913204000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 17","accession":"D6RBQ6","gene":"USP17L17","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.6038005217119027,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8042)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8042)/properties"},"_links":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8042)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8042)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8042)/publications"},"_namespace":null},{"id":8043,"version":2,"created":1554913205000,"modified":1554913205000,"deprecated":false,"name":"Endogenous retrovirus group K member 24 Np9 protein","accession":"P61581","gene":"ERVK-24","description":"May possess a function in tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8043)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8043)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8043)/links"},"_synonyms":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8043)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8043)/publications"},"_namespace":null},{"id":8044,"version":2,"created":1554913205000,"modified":1554913205000,"deprecated":false,"name":"Endogenous retrovirus group K member 10 Np9 protein","accession":"P61580","gene":"ERVK-10","description":"May possess a function in tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6989700043360189,"self":"https://pharos.nih.gov/idg/api/v1/targets(8044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8044)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8044)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8044)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8044)/publications"},"_namespace":null},{"id":8045,"version":2,"created":1554913205000,"modified":1554913205000,"deprecated":false,"name":"Endogenous retrovirus group K member 5 Np9 protein","accession":"P61583","gene":"ERVK-5","description":"May possess a function in tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8045)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8045)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8045)/links"},"_synonyms":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8045)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8045)/publications"},"_namespace":null},{"id":8046,"version":2,"created":1554913205000,"modified":1554913205000,"deprecated":false,"name":"Endogenous retrovirus group K member 7 Np9 protein","accession":"P61582","gene":"ERVK-7","description":"May possess a function in tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8046)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8046)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8046)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8046)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8046)/publications"},"_namespace":null},{"id":8047,"version":3,"created":1554913205000,"modified":1555037972000,"deprecated":false,"name":"Tectonic-3","accession":"Q6NUS6","gene":"TCTN3","description":"Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.12166924991540969,"antibodyCount":132,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.603788,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":33.4891531847246,"pubTatorScore":0.28254643891099157,"self":"https://pharos.nih.gov/idg/api/v1/targets(8047)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(8047)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8047)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8047)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8047)/publications"},"_namespace":null},{"id":8048,"version":2,"created":1554913209000,"modified":1554913212000,"deprecated":false,"name":"Rho-related GTP-binding protein RhoE","accession":"P61587","gene":"RND3","description":"Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0761526380459694,"antibodyCount":146,"monoclonalCount":42,"pubmedCount":null,"jensenScore":133.812984,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.11135197202178,"pubTatorScore":1.7188984676636452,"self":"https://pharos.nih.gov/idg/api/v1/targets(8048)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(8048)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(8048)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8048)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8048)/publications"},"_namespace":null},{"id":8049,"version":3,"created":1554913213000,"modified":1555037974000,"deprecated":false,"name":"Transforming protein RhoA","accession":"P61586","gene":"RHOA","description":"(Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.540954483205393,"antibodyCount":501,"monoclonalCount":201,"pubmedCount":null,"jensenScore":3332.725523,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":57.578697439109845,"pubTatorScore":3.217243580731407,"self":"https://pharos.nih.gov/idg/api/v1/targets(8049)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1442,"href":"https://pharos.nih.gov/idg/api/v1/targets(8049)/properties"},"_links":{"count":1964,"href":"https://pharos.nih.gov/idg/api/v1/targets(8049)/links"},"_synonyms":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(8049)/synonyms"},"_publications":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(8049)/publications"},"_namespace":null},{"id":8050,"version":2,"created":1554913224000,"modified":1554913224000,"deprecated":false,"name":"Putative cytochrome P450 family member 4F30","accession":"Q9H0H9","gene":"CYP4F30P","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.4995134302937068,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8050)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8050)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8050)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8050)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8050)/publications"},"_namespace":null},{"id":8051,"version":3,"created":1554913224000,"modified":1555037978000,"deprecated":false,"name":"Rac GTPase-activating protein 1","accession":"Q9H0H5","gene":"RACGAP1","description":"Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6944500184991667,"antibodyCount":382,"monoclonalCount":36,"pubmedCount":null,"jensenScore":57.551011,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":49.398773956712255,"pubTatorScore":1.7799143477282224,"self":"https://pharos.nih.gov/idg/api/v1/targets(8051)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(8051)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8051)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(8051)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8051)/publications"},"_namespace":null},{"id":8052,"version":2,"created":1554913229000,"modified":1554913232000,"deprecated":false,"name":"Integrator complex subunit 2","accession":"Q9H0H0","gene":"INTS2","description":"Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.021189300155674277,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.045455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.88099097082801,"pubTatorScore":-1.3617304417923015,"self":"https://pharos.nih.gov/idg/api/v1/targets(8052)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(8052)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(8052)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8052)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8052)/publications"},"_namespace":null},{"id":8053,"version":2,"created":1554913233000,"modified":1554913235000,"deprecated":false,"name":"Kelch-like protein 25","accession":"Q9H0H3","gene":"KLHL25","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.41077723848017,"antibodyCount":201,"monoclonalCount":53,"pubmedCount":null,"jensenScore":1.680834,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.510162602583087,"pubTatorScore":-0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8053)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(8053)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(8053)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8053)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8053)/publications"},"_namespace":null},{"id":8054,"version":2,"created":1554913236000,"modified":1554913239000,"deprecated":false,"name":"Cytospin-B","accession":"Q5M775","gene":"SPECC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.960940600319772,"antibodyCount":157,"monoclonalCount":0,"pubmedCount":null,"jensenScore":87.437406,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.15817830127892,"pubTatorScore":2.4377235707380565,"self":"https://pharos.nih.gov/idg/api/v1/targets(8054)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(8054)/properties"},"_links":{"count":1157,"href":"https://pharos.nih.gov/idg/api/v1/targets(8054)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8054)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8054)/publications"},"_namespace":null},{"id":8055,"version":3,"created":1554913240000,"modified":1555037980000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase D","accession":"Q08752","gene":"PPID","description":"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.7282471193668762,"antibodyCount":229,"monoclonalCount":12,"pubmedCount":null,"jensenScore":58.34226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.67215251412251,"pubTatorScore":2.0241547595071463,"self":"https://pharos.nih.gov/idg/api/v1/targets(8055)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(8055)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(8055)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8055)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8055)/publications"},"_namespace":null},{"id":8056,"version":3,"created":1554913248000,"modified":1555037981000,"deprecated":false,"name":"Tubulin polymerization-promoting protein family member 2","accession":"P59282","gene":"TPPP2","description":"May bind tubulin but has no microtubule bundling activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3891660793701459,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.025108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":14.883768745393418,"pubTatorScore":0.7621782744699916,"self":"https://pharos.nih.gov/idg/api/v1/targets(8056)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(8056)/properties"},"_links":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(8056)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8056)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8056)/publications"},"_namespace":null},{"id":8057,"version":2,"created":1554913250000,"modified":1554913254000,"deprecated":false,"name":"Nucleolar MIF4G domain-containing protein 1","accession":"Q5C9Z4","gene":"NOM1","description":"Plays a role in targeting PPP1CA to the nucleolus.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.328093366132128,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.136708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.27594761374624,"pubTatorScore":1.129797260492053,"self":"https://pharos.nih.gov/idg/api/v1/targets(8057)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(8057)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(8057)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8057)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8057)/publications"},"_namespace":null},{"id":8058,"version":2,"created":1554913255000,"modified":1554913258000,"deprecated":false,"name":"Transmembrane and TPR repeat-containing protein 3","accession":"Q6ZXV5","gene":"TMTC3","description":"Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.14819119864510755,"antibodyCount":14,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.070238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.02441786766014,"pubTatorScore":2.670477785119791,"self":"https://pharos.nih.gov/idg/api/v1/targets(8058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(8058)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(8058)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8058)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8058)/publications"},"_namespace":null},{"id":8059,"version":2,"created":1554913259000,"modified":1554913261000,"deprecated":false,"name":"N-alpha-acetyltransferase 20","accession":"P61599","gene":"NAA20","description":"Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.148227958509554,"antibodyCount":92,"monoclonalCount":23,"pubmedCount":null,"jensenScore":14.954544,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.324329711796914,"pubTatorScore":0.7494785989393855,"self":"https://pharos.nih.gov/idg/api/v1/targets(8059)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(8059)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(8059)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8059)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8059)/publications"},"_namespace":null},{"id":8060,"version":3,"created":1554913262000,"modified":1555037982000,"deprecated":false,"name":"Probable C-mannosyltransferase DPY19L2","accession":"Q6NUT2","gene":"DPY19L2","description":"Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8318211355879743,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":120.899305,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.02170611139272,"pubTatorScore":1.3720827029498388,"self":"https://pharos.nih.gov/idg/api/v1/targets(8060)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(8060)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(8060)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8060)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8060)/publications"},"_namespace":null},{"id":8061,"version":2,"created":1554913265000,"modified":1554913267000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 12","accession":"Q6NUT3","gene":"MFSD12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.50450179689201,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8061)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(8061)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(8061)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8061)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8061)/publications"},"_namespace":null},{"id":8062,"version":2,"created":1554913268000,"modified":1554913271000,"deprecated":false,"name":"Nuclear speckle splicing regulatory protein 1","accession":"Q9H0G5","gene":"NSRP1","description":"RNA-binding protein that mediates pre-mRNA alternative splicing regulation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8151348293761186,"antibodyCount":84,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.675974,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.52715999098834,"pubTatorScore":0.8409420593635563,"self":"https://pharos.nih.gov/idg/api/v1/targets(8062)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(8062)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(8062)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8062)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8062)/publications"},"_namespace":null},{"id":8063,"version":3,"created":1554913272000,"modified":1555037984000,"deprecated":false,"name":"Hemoglobin subunit mu","accession":"Q6B0K9","gene":"HBM","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.1047145048851728,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":131.05044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":12.529810497590745,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8063)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8063)/properties"},"_links":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(8063)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8063)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8063)/publications"},"_namespace":null},{"id":8064,"version":3,"created":1554913273000,"modified":1555037985000,"deprecated":false,"name":"Histone H3.3","accession":"P84243","gene":"H3F3B","description":"Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1499820778381165,"antibodyCount":458,"monoclonalCount":113,"pubmedCount":null,"jensenScore":122.489243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.66174402535991,"pubTatorScore":1.0969513906150943,"self":"https://pharos.nih.gov/idg/api/v1/targets(8064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":541,"href":"https://pharos.nih.gov/idg/api/v1/targets(8064)/properties"},"_links":{"count":2204,"href":"https://pharos.nih.gov/idg/api/v1/targets(8064)/links"},"_synonyms":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(8064)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8064)/publications"},"_namespace":null},{"id":8065,"version":2,"created":1554913282000,"modified":1554913286000,"deprecated":false,"name":"Transmembrane protein 214","accession":"Q6NUQ4","gene":"TMEM214","description":"Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":85,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.989011,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.764720442263755,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(8065)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(8065)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8065)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8065)/publications"},"_namespace":null},{"id":8066,"version":3,"created":1554913287000,"modified":1555037988000,"deprecated":false,"name":"RAD50-interacting protein 1","accession":"Q6NUQ1","gene":"RINT1","description":"Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.266052399182979,"antibodyCount":67,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.963708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":31.68445078750666,"pubTatorScore":1.1996485371896988,"self":"https://pharos.nih.gov/idg/api/v1/targets(8066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(8066)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(8066)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8066)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8066)/publications"},"_namespace":null},{"id":8067,"version":3,"created":1554913291000,"modified":1555037989000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 6","accession":"Q9H0F7","gene":"ARL6","description":"Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5826314369924431,"antibodyCount":86,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.919299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.13927032000212,"pubTatorScore":1.4296477138439094,"self":"https://pharos.nih.gov/idg/api/v1/targets(8067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(8067)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(8067)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8067)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8067)/publications"},"_namespace":null},{"id":8068,"version":3,"created":1554913296000,"modified":1555037991000,"deprecated":false,"name":"Sharpin","accession":"Q9H0F6","gene":"SHARPIN","description":"Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3438148519239534,"antibodyCount":127,"monoclonalCount":8,"pubmedCount":null,"jensenScore":25.401887,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":35.95103269489481,"pubTatorScore":1.280798716633906,"self":"https://pharos.nih.gov/idg/api/v1/targets(8068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(8068)/properties"},"_links":{"count":1009,"href":"https://pharos.nih.gov/idg/api/v1/targets(8068)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8068)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8068)/publications"},"_namespace":null},{"id":8069,"version":2,"created":1554913300000,"modified":1554913302000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF38","accession":"Q9H0F5","gene":"RNF38","description":"Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.36486354610656596,"antibodyCount":75,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.964041,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.48661598977111,"pubTatorScore":0.46900329894359394,"self":"https://pharos.nih.gov/idg/api/v1/targets(8069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(8069)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(8069)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8069)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8069)/publications"},"_namespace":null},{"id":8070,"version":2,"created":1554913303000,"modified":1554913303000,"deprecated":false,"name":"Putative protein RNF216-like","accession":"Q6NUR6","gene":"RNF216P1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.355495169947268,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8070)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8070)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8070)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8070)/publications"},"_namespace":null},{"id":8071,"version":2,"created":1554913303000,"modified":1554913307000,"deprecated":false,"name":"Bromodomain-containing protein 8","accession":"Q9H0E9","gene":"BRD8","description":"May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.6918491847164467,"antibodyCount":117,"monoclonalCount":26,"pubmedCount":null,"jensenScore":6.072035,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.67221025507452,"pubTatorScore":1.4625292398298213,"self":"https://pharos.nih.gov/idg/api/v1/targets(8071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(8071)/properties"},"_links":{"count":1153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8071)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8071)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8071)/publications"},"_namespace":null},{"id":8072,"version":3,"created":1554913308000,"modified":1555037992000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 44","accession":"Q9H0E7","gene":"USP44","description":"Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9929921337736093,"antibodyCount":189,"monoclonalCount":135,"pubmedCount":null,"jensenScore":11.179599,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.97300437018583,"pubTatorScore":0.6469881108840585,"self":"https://pharos.nih.gov/idg/api/v1/targets(8072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(8072)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(8072)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8072)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8072)/publications"},"_namespace":null},{"id":8073,"version":3,"created":1554913311000,"modified":1555037993000,"deprecated":false,"name":"Basal cell adhesion molecule","accession":"P50895","gene":"BCAM","description":"Laminin alpha-5 receptor. May mediate intracellular signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.375359063190528,"antibodyCount":211,"monoclonalCount":106,"pubmedCount":null,"jensenScore":232.026376,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":43.09493124262124,"pubTatorScore":2.1170332270945345,"self":"https://pharos.nih.gov/idg/api/v1/targets(8073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(8073)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(8073)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8073)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8073)/publications"},"_namespace":null},{"id":8074,"version":2,"created":1554913315000,"modified":1554913316000,"deprecated":false,"name":"C-C motif chemokine 4-like","accession":"Q8NHW4","gene":"CCL4L2","description":"Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6588366231192206,"antibodyCount":67,"monoclonalCount":22,"pubmedCount":null,"jensenScore":374.994052,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.212625180138827,"pubTatorScore":1.6156030558434202,"self":"https://pharos.nih.gov/idg/api/v1/targets(8074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8074)/properties"},"_links":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(8074)/links"},"_synonyms":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(8074)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8074)/publications"},"_namespace":null},{"id":8075,"version":2,"created":1554913316000,"modified":1554913317000,"deprecated":false,"name":"60S acidic ribosomal protein P0-like","accession":"Q8NHW5","gene":"RPLP0P6","description":"Ribosomal protein P0 is the functional equivalent of E.coli protein L10.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.6453966319653783,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":60.108083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.866459315560642,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8075)/properties"},"_links":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(8075)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8075)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8075)/publications"},"_namespace":null},{"id":8076,"version":2,"created":1554913317000,"modified":1554913321000,"deprecated":false,"name":"Palmitoyl-protein thioesterase 1","accession":"P50897","gene":"PPT1","description":"Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.6396641346673126,"antibodyCount":305,"monoclonalCount":56,"pubmedCount":null,"jensenScore":433.815918,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.42764778805251,"pubTatorScore":2.546180914585168,"self":"https://pharos.nih.gov/idg/api/v1/targets(8076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(8076)/properties"},"_links":{"count":1235,"href":"https://pharos.nih.gov/idg/api/v1/targets(8076)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8076)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8076)/publications"},"_namespace":null},{"id":8077,"version":2,"created":1554913322000,"modified":1554913324000,"deprecated":false,"name":"Transcription factor MafA","accession":"Q8NHW3","gene":"MAFA","description":"Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3609935916964053,"antibodyCount":195,"monoclonalCount":20,"pubmedCount":null,"jensenScore":22.996697,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.829792599995947,"pubTatorScore":1.8941126278483944,"self":"https://pharos.nih.gov/idg/api/v1/targets(8077)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(8077)/properties"},"_links":{"count":699,"href":"https://pharos.nih.gov/idg/api/v1/targets(8077)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8077)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8077)/publications"},"_namespace":null},{"id":8078,"version":2,"created":1554913325000,"modified":1554913325000,"deprecated":false,"name":"Olfactory receptor 4A47","accession":"Q6IF82","gene":"OR4A47","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":155,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.867571441936982,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8078)/properties"},"_links":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8078)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8078)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8078)/publications"},"_namespace":null},{"id":8079,"version":2,"created":1554913325000,"modified":1554913329000,"deprecated":false,"name":"Kinesin-like protein KIF18A","accession":"Q8NI77","gene":"KIF18A","description":"Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4620474900152665,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":32.347751,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.85027724032352,"pubTatorScore":1.5338389381427557,"self":"https://pharos.nih.gov/idg/api/v1/targets(8079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(8079)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(8079)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8079)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8079)/publications"},"_namespace":null},{"id":8080,"version":2,"created":1554913330000,"modified":1554913332000,"deprecated":false,"name":"Uncharacterized protein C16orf52","accession":"Q8NHV5","gene":"MOSMO","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(8080)/properties"},"_links":{"count":709,"href":"https://pharos.nih.gov/idg/api/v1/targets(8080)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8080)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8080)/publications"},"_namespace":null},{"id":8081,"version":2,"created":1554913333000,"modified":1554913334000,"deprecated":false,"name":"Rhox homeobox family member 1","accession":"Q8NHV9","gene":"RHOXF1","description":"Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.7514990553019931,"antibodyCount":106,"monoclonalCount":8,"pubmedCount":null,"jensenScore":5.383731,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.22299536353769,"pubTatorScore":0.9040172465621185,"self":"https://pharos.nih.gov/idg/api/v1/targets(8081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8081)/properties"},"_links":{"count":668,"href":"https://pharos.nih.gov/idg/api/v1/targets(8081)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8081)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8081)/publications"},"_namespace":null},{"id":8082,"version":2,"created":1554913335000,"modified":1554913335000,"deprecated":false,"name":"Olfactory receptor 4C11","accession":"Q6IEV9","gene":"OR4C11","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.23408320494763177,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.711538,"patentCount":99,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.881929759965624,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8082)/properties"},"_links":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8082)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8082)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8082)/publications"},"_namespace":null},{"id":8083,"version":3,"created":1554913335000,"modified":1555037995000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RBX1","accession":"P62877","gene":"RBX1","description":"E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9426637352488263,"antibodyCount":260,"monoclonalCount":16,"pubmedCount":null,"jensenScore":72.077068,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":38.53623640433916,"pubTatorScore":1.9856176069220273,"self":"https://pharos.nih.gov/idg/api/v1/targets(8083)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(8083)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(8083)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(8083)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8083)/publications"},"_namespace":null},{"id":8084,"version":3,"created":1554913339000,"modified":1555037997000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2","accession":"P62879","gene":"GNB2","description":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.46729526841674285,"antibodyCount":112,"monoclonalCount":8,"pubmedCount":null,"jensenScore":3.150809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":44.317838942723164,"pubTatorScore":0.6185461508524724,"self":"https://pharos.nih.gov/idg/api/v1/targets(8084)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":507,"href":"https://pharos.nih.gov/idg/api/v1/targets(8084)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(8084)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8084)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8084)/publications"},"_namespace":null},{"id":8085,"version":3,"created":1554913344000,"modified":1555037999000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1","accession":"P62873","gene":"GNB1","description":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2217619717726536,"antibodyCount":165,"monoclonalCount":1,"pubmedCount":null,"jensenScore":19.33833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":54.23091123098196,"pubTatorScore":0.9807442232540478,"self":"https://pharos.nih.gov/idg/api/v1/targets(8085)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":620,"href":"https://pharos.nih.gov/idg/api/v1/targets(8085)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8085)/links"},"_synonyms":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(8085)/synonyms"},"_publications":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8085)/publications"},"_namespace":null},{"id":8086,"version":2,"created":1554913348000,"modified":1554913351000,"deprecated":false,"name":"DNA-directed RNA polymerases I, II, and III subunit RPABC5","accession":"P62875","gene":"POLR2L","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1279283208984086,"antibodyCount":66,"monoclonalCount":2,"pubmedCount":null,"jensenScore":13.832911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.27458020232835,"pubTatorScore":0.6507930396519307,"self":"https://pharos.nih.gov/idg/api/v1/targets(8086)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(8086)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(8086)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(8086)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8086)/publications"},"_namespace":null},{"id":8087,"version":2,"created":1554913352000,"modified":1554913355000,"deprecated":false,"name":"E3 ubiquitin-protein ligase TM129","accession":"A0AVI4","gene":"TMEM129","description":"E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.34077450649554825,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.862338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.986981072980285,"pubTatorScore":0.4238956820901333,"self":"https://pharos.nih.gov/idg/api/v1/targets(8087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(8087)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(8087)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8087)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8087)/publications"},"_namespace":null},{"id":8088,"version":3,"created":1554913356000,"modified":1555038000000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase B","accession":"P23284","gene":"PPIB","description":"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.2486600682481654,"antibodyCount":304,"monoclonalCount":96,"pubmedCount":null,"jensenScore":187.141183,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.93103648874836,"pubTatorScore":2.0027942452422085,"self":"https://pharos.nih.gov/idg/api/v1/targets(8088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":475,"href":"https://pharos.nih.gov/idg/api/v1/targets(8088)/properties"},"_links":{"count":1200,"href":"https://pharos.nih.gov/idg/api/v1/targets(8088)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8088)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8088)/publications"},"_namespace":null},{"id":8089,"version":2,"created":1554913365000,"modified":1554913367000,"deprecated":false,"name":"Fer-1-like protein 5","accession":"A0AVI2","gene":"FER1L5","description":"Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.779009475537318,"pubTatorScore":-0.3467874862246563,"self":"https://pharos.nih.gov/idg/api/v1/targets(8089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8089)/properties"},"_links":{"count":662,"href":"https://pharos.nih.gov/idg/api/v1/targets(8089)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8089)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8089)/publications"},"_namespace":null},{"id":8090,"version":2,"created":1554913367000,"modified":1554913371000,"deprecated":false,"name":"Type I iodothyronine deiodinase","accession":"P49895","gene":"DIO1","description":"Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.198578452029031,"antibodyCount":82,"monoclonalCount":9,"pubmedCount":null,"jensenScore":153.261429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.42300477338173,"pubTatorScore":1.7737606570667979,"self":"https://pharos.nih.gov/idg/api/v1/targets(8090)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(8090)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(8090)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8090)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8090)/publications"},"_namespace":null},{"id":8091,"version":3,"created":1554913372000,"modified":1555038002000,"deprecated":false,"name":"Carbonic anhydrase 6","accession":"P23280","gene":"CA6","description":"Reversible hydration of carbon dioxide. Its role in saliva is unknown.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.608313472397115,"antibodyCount":256,"monoclonalCount":35,"pubmedCount":null,"jensenScore":403.084014,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":24.324405174676,"pubTatorScore":2.1546474479213873,"self":"https://pharos.nih.gov/idg/api/v1/targets(8091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(8091)/properties"},"_links":{"count":618,"href":"https://pharos.nih.gov/idg/api/v1/targets(8091)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8091)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8091)/publications"},"_namespace":null},{"id":8092,"version":2,"created":1554913383000,"modified":1554913385000,"deprecated":false,"name":"60S ribosomal protein L4","accession":"P36578","gene":"RPL4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0990383769253746,"antibodyCount":111,"monoclonalCount":30,"pubmedCount":null,"jensenScore":122.80814,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.20582830292907,"pubTatorScore":2.4389128819781316,"self":"https://pharos.nih.gov/idg/api/v1/targets(8092)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(8092)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(8092)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8092)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8092)/publications"},"_namespace":null},{"id":8093,"version":2,"created":1554913386000,"modified":1554913390000,"deprecated":false,"name":"Pulmonary surfactant-associated protein D","accession":"P35247","gene":"SFTPD","description":"Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8148773274026753,"antibodyCount":291,"monoclonalCount":130,"pubmedCount":null,"jensenScore":698.414394,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.92552361919499,"pubTatorScore":2.7268049481140384,"self":"https://pharos.nih.gov/idg/api/v1/targets(8093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(8093)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(8093)/links"},"_synonyms":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8093)/synonyms"},"_publications":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(8093)/publications"},"_namespace":null},{"id":8094,"version":2,"created":1554913391000,"modified":1554913395000,"deprecated":false,"name":"Replication protein A 14 kDa subunit","accession":"P35244","gene":"RPA3","description":"As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8594130871954662,"antibodyCount":171,"monoclonalCount":84,"pubmedCount":null,"jensenScore":67.073759,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.90099590170907,"pubTatorScore":1.6079799983718164,"self":"https://pharos.nih.gov/idg/api/v1/targets(8094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":519,"href":"https://pharos.nih.gov/idg/api/v1/targets(8094)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8094)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8094)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8094)/publications"},"_namespace":null},{"id":8095,"version":2,"created":1554913397000,"modified":1554913399000,"deprecated":false,"name":"Arrestin-C","accession":"P36575","gene":"ARR3","description":"May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9932435268513478,"antibodyCount":161,"monoclonalCount":8,"pubmedCount":null,"jensenScore":86.326148,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.139777489486924,"pubTatorScore":2.6619016575906493,"self":"https://pharos.nih.gov/idg/api/v1/targets(8095)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(8095)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(8095)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8095)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8095)/publications"},"_namespace":null},{"id":8096,"version":2,"created":1554913400000,"modified":1554913403000,"deprecated":false,"name":"Protein NEDD1","accession":"Q8NHV4","gene":"NEDD1","description":"Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.400969439596286,"antibodyCount":159,"monoclonalCount":42,"pubmedCount":null,"jensenScore":25.906311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.704975027389445,"pubTatorScore":1.298489186005986,"self":"https://pharos.nih.gov/idg/api/v1/targets(8096)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(8096)/properties"},"_links":{"count":1131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8096)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8096)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8096)/publications"},"_namespace":null},{"id":8097,"version":2,"created":1554913404000,"modified":1554913407000,"deprecated":false,"name":"GTPase IMAP family member 7","accession":"Q8NHV1","gene":"GIMAP7","description":"The dimer has GTPase activity; the active site contains residues from both subunits.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5239631270430432,"antibodyCount":80,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.249331,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.291695601201937,"pubTatorScore":0.41218039174864657,"self":"https://pharos.nih.gov/idg/api/v1/targets(8097)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(8097)/properties"},"_links":{"count":980,"href":"https://pharos.nih.gov/idg/api/v1/targets(8097)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8097)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8097)/publications"},"_namespace":null},{"id":8098,"version":3,"created":1554913408000,"modified":1555038004000,"deprecated":false,"name":"Replication factor C subunit 4","accession":"P35249","gene":"RFC4","description":"The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1766144646448995,"antibodyCount":195,"monoclonalCount":40,"pubmedCount":null,"jensenScore":13.701685,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":44.403069117202,"pubTatorScore":0.9894705529532987,"self":"https://pharos.nih.gov/idg/api/v1/targets(8098)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(8098)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(8098)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8098)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8098)/publications"},"_namespace":null},{"id":8099,"version":3,"created":1554913413000,"modified":1555038005000,"deprecated":false,"name":"Low-density lipoprotein receptor-related protein 4","accession":"O75096","gene":"LRP4","description":"Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0557908220644032,"antibodyCount":225,"monoclonalCount":134,"pubmedCount":null,"jensenScore":117.071912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.84511388912132,"pubTatorScore":1.8797514846099217,"self":"https://pharos.nih.gov/idg/api/v1/targets(8099)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(8099)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(8099)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8099)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8099)/publications"},"_namespace":null},{"id":8100,"version":2,"created":1554913418000,"modified":1554913421000,"deprecated":false,"name":"Tudor domain-containing protein 7","accession":"Q8NHU6","gene":"TDRD7","description":"Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.1293902925891146,"antibodyCount":73,"monoclonalCount":3,"pubmedCount":null,"jensenScore":13.796661,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.39373277965726,"pubTatorScore":0.8729145472863008,"self":"https://pharos.nih.gov/idg/api/v1/targets(8100)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(8100)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(8100)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8100)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8100)/publications"},"_namespace":null},{"id":8101,"version":2,"created":1554913423000,"modified":1554913427000,"deprecated":false,"name":"Replication factor C subunit 2","accession":"P35250","gene":"RFC2","description":"The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3658871459242499,"antibodyCount":293,"monoclonalCount":119,"pubmedCount":null,"jensenScore":20.319429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.67927807482282,"pubTatorScore":1.10431674022838,"self":"https://pharos.nih.gov/idg/api/v1/targets(8101)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(8101)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(8101)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8101)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8101)/publications"},"_namespace":null},{"id":8102,"version":2,"created":1554913428000,"modified":1554913428000,"deprecated":false,"name":"Endogenous retrovirus group S71 member 1 Env polyprotein","accession":"P61550","gene":"ERVS71-1","description":"Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8102)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8102)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8102)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8102)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8102)/publications"},"_namespace":null},{"id":8103,"version":2,"created":1554913428000,"modified":1554913432000,"deprecated":false,"name":"Replication factor C subunit 1","accession":"P35251","gene":"RFC1","description":"Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4345878744314848,"antibodyCount":198,"monoclonalCount":9,"pubmedCount":null,"jensenScore":26.519777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":54.63530217954023,"pubTatorScore":2.049761488976237,"self":"https://pharos.nih.gov/idg/api/v1/targets(8103)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":632,"href":"https://pharos.nih.gov/idg/api/v1/targets(8103)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8103)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(8103)/synonyms"},"_publications":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(8103)/publications"},"_namespace":null},{"id":8104,"version":3,"created":1554913433000,"modified":1555038006000,"deprecated":false,"name":"26S proteasome non-ATPase regulatory subunit 8","accession":"P48556","gene":"PSMD8","description":"Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4367609291425667,"antibodyCount":100,"monoclonalCount":10,"pubmedCount":null,"jensenScore":24.664588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":38.98188536760436,"pubTatorScore":1.438972459070044,"self":"https://pharos.nih.gov/idg/api/v1/targets(8104)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":580,"href":"https://pharos.nih.gov/idg/api/v1/targets(8104)/properties"},"_links":{"count":1120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8104)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(8104)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8104)/publications"},"_namespace":null},{"id":8105,"version":3,"created":1554913437000,"modified":1555038009000,"deprecated":false,"name":"60S ribosomal protein L30","accession":"P62888","gene":"RPL30","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.584264799763603,"antibodyCount":183,"monoclonalCount":15,"pubmedCount":null,"jensenScore":36.548893,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":71,"knowledgeAvailability":36.636690563734504,"pubTatorScore":1.4585944325132474,"self":"https://pharos.nih.gov/idg/api/v1/targets(8105)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(8105)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(8105)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8105)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8105)/publications"},"_namespace":null},{"id":8106,"version":2,"created":1554913440000,"modified":1554913444000,"deprecated":false,"name":"Estrogen sulfotransferase","accession":"P49888","gene":"SULT1E1","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.9737855257300367,"antibodyCount":156,"monoclonalCount":40,"pubmedCount":null,"jensenScore":932.945139,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.685079743173272,"pubTatorScore":2.2050983333329,"self":"https://pharos.nih.gov/idg/api/v1/targets(8106)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(8106)/properties"},"_links":{"count":696,"href":"https://pharos.nih.gov/idg/api/v1/targets(8106)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8106)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8106)/publications"},"_namespace":null},{"id":8107,"version":3,"created":1554913444000,"modified":1555038010000,"deprecated":false,"name":"Tigger transposable element-derived protein 3","accession":"Q6B0B8","gene":"TIGD3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":108,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.257576,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":23.332012911226922,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(8107)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(8107)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(8107)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8107)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8107)/publications"},"_namespace":null},{"id":8108,"version":3,"created":1554913447000,"modified":1555038012000,"deprecated":false,"name":"Guanine nucleotide exchange factor MSS4","accession":"P47224","gene":"RABIF","description":"Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.12493873660829995,"antibodyCount":64,"monoclonalCount":28,"pubmedCount":null,"jensenScore":2.131884,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":33.55336557401703,"pubTatorScore":1.2662377193668417,"self":"https://pharos.nih.gov/idg/api/v1/targets(8108)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(8108)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(8108)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8108)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8108)/publications"},"_namespace":null},{"id":8109,"version":3,"created":1554913452000,"modified":1555038013000,"deprecated":false,"name":"Kell blood group glycoprotein","accession":"P23276","gene":"KEL","description":"Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.5928947529492823,"antibodyCount":215,"monoclonalCount":75,"pubmedCount":null,"jensenScore":385.478171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.96794053414761,"pubTatorScore":1.585943903711938,"self":"https://pharos.nih.gov/idg/api/v1/targets(8109)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(8109)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(8109)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8109)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8109)/publications"},"_namespace":null},{"id":8110,"version":3,"created":1554913455000,"modified":1555038014000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit E","accession":"P60228","gene":"EIF3E","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4746597139748296,"antibodyCount":224,"monoclonalCount":8,"pubmedCount":null,"jensenScore":32.19919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":44.17832215301535,"pubTatorScore":1.6312806445683286,"self":"https://pharos.nih.gov/idg/api/v1/targets(8110)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(8110)/properties"},"_links":{"count":1166,"href":"https://pharos.nih.gov/idg/api/v1/targets(8110)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(8110)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8110)/publications"},"_namespace":null},{"id":8111,"version":2,"created":1554913461000,"modified":1554913465000,"deprecated":false,"name":"Nuclear receptor-interacting protein 1","accession":"P48552","gene":"NRIP1","description":"Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2132308374291223,"antibodyCount":155,"monoclonalCount":13,"pubmedCount":null,"jensenScore":183.757814,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.03760209241848,"pubTatorScore":2.043495654723906,"self":"https://pharos.nih.gov/idg/api/v1/targets(8111)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":505,"href":"https://pharos.nih.gov/idg/api/v1/targets(8111)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8111)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(8111)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8111)/publications"},"_namespace":null},{"id":8112,"version":3,"created":1554913466000,"modified":1555038016000,"deprecated":false,"name":"Trafficking protein particle complex subunit 10","accession":"P48553","gene":"TRAPPC10","description":"May play a role in vesicular transport from endoplasmic reticulum to Golgi.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3353129992764523,"antibodyCount":95,"monoclonalCount":44,"pubmedCount":null,"jensenScore":17.32945,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.50346301055313,"pubTatorScore":1.0328636371119533,"self":"https://pharos.nih.gov/idg/api/v1/targets(8112)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(8112)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(8112)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8112)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8112)/publications"},"_namespace":null},{"id":8113,"version":3,"created":1554913471000,"modified":1555038017000,"deprecated":false,"name":"Interferon alpha/beta receptor 2","accession":"P48551","gene":"IFNAR2","description":"Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-1.9331052047353738,"antibodyCount":268,"monoclonalCount":56,"pubmedCount":null,"jensenScore":79.461753,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.41052466932131,"pubTatorScore":1.9925862852853982,"self":"https://pharos.nih.gov/idg/api/v1/targets(8113)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(8113)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(8113)/links"},"_synonyms":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(8113)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8113)/publications"},"_namespace":null},{"id":8114,"version":2,"created":1554913476000,"modified":1554913479000,"deprecated":false,"name":"Tyrosine-protein phosphatase non-receptor type 7","accession":"P35236","gene":"PTPN7","description":"Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.5275115213821984,"antibodyCount":222,"monoclonalCount":37,"pubmedCount":null,"jensenScore":35.939192,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.21540702009209,"pubTatorScore":1.3418413638485887,"self":"https://pharos.nih.gov/idg/api/v1/targets(8114)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(8114)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(8114)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(8114)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8114)/publications"},"_namespace":null},{"id":8115,"version":2,"created":1554913480000,"modified":1554913483000,"deprecated":false,"name":"BTB/POZ domain-containing protein KCTD1","accession":"Q719H9","gene":"KCTD1","description":"May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.273757874568112,"antibodyCount":83,"monoclonalCount":0,"pubmedCount":null,"jensenScore":183.113109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.196246990634968,"pubTatorScore":1.9715166947430642,"self":"https://pharos.nih.gov/idg/api/v1/targets(8115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(8115)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(8115)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8115)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8115)/publications"},"_namespace":null},{"id":8116,"version":2,"created":1554913484000,"modified":1554913486000,"deprecated":false,"name":"Cilia- and flagella-associated protein 61","accession":"Q8NHU2","gene":"CFAP61","description":"May regulate cilium motility through its role in the assembly of the axonemal radial spokes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.36164989368609,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(8116)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(8116)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8116)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8116)/publications"},"_namespace":null},{"id":8117,"version":3,"created":1554913487000,"modified":1555038019000,"deprecated":false,"name":"Connector enhancer of kinase suppressor of ras 3","accession":"Q6P9H4","gene":"CNKSR3","description":"Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.47712125471966244,"antibodyCount":116,"monoclonalCount":35,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":31.936945597850674,"pubTatorScore":0.9155756809572304,"self":"https://pharos.nih.gov/idg/api/v1/targets(8117)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(8117)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(8117)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8117)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8117)/publications"},"_namespace":null},{"id":8118,"version":3,"created":1554913491000,"modified":1555038020000,"deprecated":false,"name":"Olfactory receptor 52W1","accession":"Q6IF63","gene":"OR52W1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":170,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":10.02706873088849,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8118)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8118)/properties"},"_links":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(8118)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8118)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8118)/publications"},"_namespace":null},{"id":8119,"version":2,"created":1554913492000,"modified":1554913496000,"deprecated":false,"name":"GTPase IMAP family member 6","accession":"Q6P9H5","gene":"GIMAP6","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4901926699732647,"antibodyCount":62,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.338248,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.816282456274127,"pubTatorScore":0.1995722634747773,"self":"https://pharos.nih.gov/idg/api/v1/targets(8119)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(8119)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(8119)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8119)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8119)/publications"},"_namespace":null},{"id":8120,"version":2,"created":1554913496000,"modified":1554913502000,"deprecated":false,"name":"Phosphatidylcholine:ceramide cholinephosphotransferase 2","accession":"Q8NHU3","gene":"SGMS2","description":"Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.459241949167343,"antibodyCount":204,"monoclonalCount":9,"pubmedCount":null,"jensenScore":31.124637,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.586450220418577,"pubTatorScore":1.5924899806657218,"self":"https://pharos.nih.gov/idg/api/v1/targets(8120)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(8120)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(8120)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8120)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8120)/publications"},"_namespace":null},{"id":8121,"version":2,"created":1554913503000,"modified":1554913503000,"deprecated":false,"name":"Cancer/testis antigen family 45 member A3","accession":"Q8NHU0","gene":"CT45A3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":35,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.2,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.203314961419696,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8121)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8121)/properties"},"_links":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8121)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8121)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8121)/publications"},"_namespace":null},{"id":8122,"version":3,"created":1554913503000,"modified":1555038020000,"deprecated":false,"name":"Atypical kinase COQ8A, mitochondrial","accession":"Q8NI60","gene":"COQ8A","description":"Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.5725593351557987,"antibodyCount":240,"monoclonalCount":84,"pubmedCount":null,"jensenScore":36.537515,"patentCount":1388,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":1.253380148264797,"self":"https://pharos.nih.gov/idg/api/v1/targets(8122)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(8122)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(8122)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8122)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8122)/publications"},"_namespace":null},{"id":8123,"version":3,"created":1554913507000,"modified":1555038021000,"deprecated":false,"name":"Serpin B6","accession":"P35237","gene":"SERPINB6","description":"May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.702040437305413,"antibodyCount":169,"monoclonalCount":51,"pubmedCount":null,"jensenScore":469.625204,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.62390280639001,"pubTatorScore":1.684231927337645,"self":"https://pharos.nih.gov/idg/api/v1/targets(8123)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(8123)/properties"},"_links":{"count":1141,"href":"https://pharos.nih.gov/idg/api/v1/targets(8123)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8123)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8123)/publications"},"_namespace":null},{"id":8124,"version":2,"created":1554913511000,"modified":1554913514000,"deprecated":false,"name":"60S ribosomal protein L39","accession":"P62891","gene":"RPL39","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0474869121753554,"antibodyCount":123,"monoclonalCount":4,"pubmedCount":null,"jensenScore":19.353541,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.390674436751983,"pubTatorScore":1.221703957759959,"self":"https://pharos.nih.gov/idg/api/v1/targets(8124)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(8124)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(8124)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8124)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8124)/publications"},"_namespace":null},{"id":8125,"version":3,"created":1554913514000,"modified":1555038022000,"deprecated":false,"name":"Slit homolog 3 protein","accession":"O75094","gene":"SLIT3","description":"May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1832497797412143,"antibodyCount":142,"monoclonalCount":32,"pubmedCount":null,"jensenScore":163.808235,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.4214210549424,"pubTatorScore":1.4985726644605128,"self":"https://pharos.nih.gov/idg/api/v1/targets(8125)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(8125)/properties"},"_links":{"count":993,"href":"https://pharos.nih.gov/idg/api/v1/targets(8125)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8125)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8125)/publications"},"_namespace":null},{"id":8126,"version":2,"created":1554913519000,"modified":1554913522000,"deprecated":false,"name":"Multiple epidermal growth factor-like domains protein 6","accession":"O75095","gene":"MEGF6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.12078277595476614,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.792807,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.023488773142397,"pubTatorScore":-0.13444241571236934,"self":"https://pharos.nih.gov/idg/api/v1/targets(8126)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(8126)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(8126)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8126)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8126)/publications"},"_namespace":null},{"id":8127,"version":2,"created":1554913523000,"modified":1554913531000,"deprecated":false,"name":"Breakpoint cluster region protein","accession":"P11274","gene":"BCR","description":"GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.9960528826769597,"antibodyCount":437,"monoclonalCount":42,"pubmedCount":null,"jensenScore":934.228801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":58.199229651106826,"pubTatorScore":2.7486498838475866,"self":"https://pharos.nih.gov/idg/api/v1/targets(8127)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(8127)/properties"},"_links":{"count":1473,"href":"https://pharos.nih.gov/idg/api/v1/targets(8127)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(8127)/synonyms"},"_publications":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(8127)/publications"},"_namespace":null},{"id":8128,"version":3,"created":1554913533000,"modified":1555038024000,"deprecated":false,"name":"Slit homolog 1 protein","accession":"O75093","gene":"SLIT1","description":"Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7102748501666716,"antibodyCount":121,"monoclonalCount":3,"pubmedCount":null,"jensenScore":44.772911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.50058932589546,"pubTatorScore":1.2170034804486682,"self":"https://pharos.nih.gov/idg/api/v1/targets(8128)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(8128)/properties"},"_links":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(8128)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8128)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8128)/publications"},"_namespace":null},{"id":8129,"version":3,"created":1554913536000,"modified":1555038024000,"deprecated":false,"name":"Recoverin","accession":"P35243","gene":"RCVRN","description":"Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.437778532285649,"antibodyCount":355,"monoclonalCount":101,"pubmedCount":null,"jensenScore":283.17484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":24.511817306694123,"pubTatorScore":2.299350168117552,"self":"https://pharos.nih.gov/idg/api/v1/targets(8129)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(8129)/properties"},"_links":{"count":668,"href":"https://pharos.nih.gov/idg/api/v1/targets(8129)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8129)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8129)/publications"},"_namespace":null},{"id":8130,"version":2,"created":1554913538000,"modified":1554913542000,"deprecated":false,"name":"Zinc finger protein 449","accession":"Q6P9G9","gene":"ZNF449","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.06214790530119616,"antibodyCount":116,"monoclonalCount":17,"pubmedCount":null,"jensenScore":1.169643,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.823963459495015,"pubTatorScore":0.32451106865589924,"self":"https://pharos.nih.gov/idg/api/v1/targets(8130)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8130)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(8130)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8130)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8130)/publications"},"_namespace":null},{"id":8131,"version":2,"created":1554913542000,"modified":1554913546000,"deprecated":false,"name":"Radixin","accession":"P35241","gene":"RDX","description":"Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4784448276672313,"antibodyCount":333,"monoclonalCount":46,"pubmedCount":null,"jensenScore":221.353228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.230027046428795,"pubTatorScore":2.7939208733701593,"self":"https://pharos.nih.gov/idg/api/v1/targets(8131)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(8131)/properties"},"_links":{"count":1174,"href":"https://pharos.nih.gov/idg/api/v1/targets(8131)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(8131)/synonyms"},"_publications":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8131)/publications"},"_namespace":null},{"id":8132,"version":3,"created":1554913548000,"modified":1555038025000,"deprecated":false,"name":"Merlin","accession":"P35240","gene":"NF2","description":"Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1730121946452345,"antibodyCount":457,"monoclonalCount":26,"pubmedCount":null,"jensenScore":1539.986827,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":55.36660950074139,"pubTatorScore":3.068567610998877,"self":"https://pharos.nih.gov/idg/api/v1/targets(8132)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":735,"href":"https://pharos.nih.gov/idg/api/v1/targets(8132)/properties"},"_links":{"count":1592,"href":"https://pharos.nih.gov/idg/api/v1/targets(8132)/links"},"_synonyms":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(8132)/synonyms"},"_publications":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(8132)/publications"},"_namespace":null},{"id":8133,"version":2,"created":1554913557000,"modified":1554913562000,"deprecated":false,"name":"60S ribosomal protein L31","accession":"P62899","gene":"RPL31","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2914827328781215,"antibodyCount":112,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.477637,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.242561250233095,"pubTatorScore":1.5233251529034777,"self":"https://pharos.nih.gov/idg/api/v1/targets(8133)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(8133)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(8133)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8133)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8133)/publications"},"_namespace":null},{"id":8134,"version":2,"created":1554913563000,"modified":1554913563000,"deprecated":false,"name":"Endogenous retrovirus group K member 7 Env polyprotein","accession":"P61567","gene":"ERVK-7","description":"TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8134)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8134)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8134)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8134)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8134)/publications"},"_namespace":null},{"id":8135,"version":3,"created":1554913563000,"modified":1555038028000,"deprecated":false,"name":"Gastric inhibitory polypeptide receptor","accession":"P48546","gene":"GIPR","description":"This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.8162548284756015,"antibodyCount":347,"monoclonalCount":74,"pubmedCount":null,"jensenScore":78.693708,"patentCount":4460,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.50240238102983,"pubTatorScore":1.7780521837524097,"self":"https://pharos.nih.gov/idg/api/v1/targets(8135)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(8135)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(8135)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8135)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8135)/publications"},"_namespace":null},{"id":8136,"version":2,"created":1554913570000,"modified":1554913570000,"deprecated":false,"name":"Endogenous retrovirus group K member 24 Env polyprotein","accession":"P61566","gene":"ERVK-24","description":"TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8136)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8136)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8136)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8136)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8136)/publications"},"_namespace":null},{"id":8137,"version":2,"created":1554913570000,"modified":1554913570000,"deprecated":false,"name":"Endogenous retrovirus group K member 21 Env polyprotein","accession":"P61565","gene":"ERVK-21","description":"TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8137)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8137)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8137)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8137)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8137)/publications"},"_namespace":null},{"id":8138,"version":3,"created":1554913570000,"modified":1555038029000,"deprecated":false,"name":"G protein-activated inward rectifier potassium channel 4","accession":"P48544","gene":"KCNJ5","description":"This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.2984691430971314,"antibodyCount":120,"monoclonalCount":7,"pubmedCount":null,"jensenScore":202.13329,"patentCount":24291,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":37.21657856721995,"pubTatorScore":2.1912789142375746,"self":"https://pharos.nih.gov/idg/api/v1/targets(8138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/synonyms"},"_publications":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8138)/publications"},"_namespace":null},{"id":8139,"version":2,"created":1554913576000,"modified":1554913580000,"deprecated":false,"name":"G protein-activated inward rectifier potassium channel 1","accession":"P48549","gene":"KCNJ3","description":"This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.344316157218975,"antibodyCount":267,"monoclonalCount":74,"pubmedCount":null,"jensenScore":217.248882,"patentCount":12933,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.28652707361,"pubTatorScore":2.0574792866840523,"self":"https://pharos.nih.gov/idg/api/v1/targets(8139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8139)/publications"},"_namespace":null},{"id":8140,"version":2,"created":1554913581000,"modified":1554913587000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily C member 1","accession":"P48547","gene":"KCNC1","description":"Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.461628632232837,"antibodyCount":308,"monoclonalCount":63,"pubmedCount":null,"jensenScore":275.71541,"patentCount":9049,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.17649349615046,"pubTatorScore":2.034424623231145,"self":"https://pharos.nih.gov/idg/api/v1/targets(8140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8140)/publications"},"_namespace":null},{"id":8141,"version":3,"created":1554913588000,"modified":1555038031000,"deprecated":false,"name":"Splicing factor, proline- and glutamine-rich","accession":"P23246","gene":"SFPQ","description":"DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.716063853757251,"antibodyCount":221,"monoclonalCount":65,"pubmedCount":null,"jensenScore":38.305628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":51.517667455873216,"pubTatorScore":1.9453024578807494,"self":"https://pharos.nih.gov/idg/api/v1/targets(8141)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(8141)/properties"},"_links":{"count":1254,"href":"https://pharos.nih.gov/idg/api/v1/targets(8141)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8141)/synonyms"},"_publications":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8141)/publications"},"_namespace":null},{"id":8142,"version":2,"created":1554913593000,"modified":1554913593000,"deprecated":false,"name":"Putative endogenous retrovirus group K member 11-1 Env polyprotein","accession":"P61568","gene":"ERVK11-1","description":"Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8142)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8142)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8142)/links"},"_synonyms":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8142)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8142)/publications"},"_namespace":null},{"id":8143,"version":3,"created":1554913593000,"modified":1555038033000,"deprecated":false,"name":"Insulin-like growth factor-binding protein 6","accession":"P24592","gene":"IGFBP6","description":"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.0786975377492243,"antibodyCount":254,"monoclonalCount":58,"pubmedCount":null,"jensenScore":126.124993,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":35.84224644371663,"pubTatorScore":2.0231799325743745,"self":"https://pharos.nih.gov/idg/api/v1/targets(8143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8143)/publications"},"_namespace":null},{"id":8144,"version":3,"created":1554913599000,"modified":1555038034000,"deprecated":false,"name":"Transcription factor E2F8","accession":"A0AVK6","gene":"E2F8","description":"Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3683129724522838,"antibodyCount":147,"monoclonalCount":22,"pubmedCount":null,"jensenScore":22.745361,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.26869369467345,"pubTatorScore":1.0638474514075371,"self":"https://pharos.nih.gov/idg/api/v1/targets(8144)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8144)/publications"},"_namespace":null},{"id":8145,"version":2,"created":1554913602000,"modified":1554913608000,"deprecated":false,"name":"Insulin-like growth factor-binding protein 5","accession":"P24593","gene":"IGFBP5","description":"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.5272128440777224,"antibodyCount":278,"monoclonalCount":66,"pubmedCount":null,"jensenScore":351.83506,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.45332743016764,"pubTatorScore":2.3830512439370684,"self":"https://pharos.nih.gov/idg/api/v1/targets(8145)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(8145)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8145)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8145)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(8145)/publications"},"_namespace":null},{"id":8146,"version":2,"created":1554913610000,"modified":1554913613000,"deprecated":false,"name":"Activator of 90 kDa heat shock protein ATPase homolog 2","accession":"Q719I0","gene":"AHSA2P","description":"Co-chaperone that stimulates HSP90 ATPase activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.05435766290165201,"antibodyCount":76,"monoclonalCount":4,"pubmedCount":null,"jensenScore":1.249145,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(8146)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(8146)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(8146)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8146)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8146)/publications"},"_namespace":null},{"id":8147,"version":3,"created":1554913613000,"modified":1555038035000,"deprecated":false,"name":"Galanin receptor type 1","accession":"P47211","gene":"GALR1","description":"Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.054733837354705,"antibodyCount":255,"monoclonalCount":1,"pubmedCount":null,"jensenScore":106.84077,"patentCount":5661,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.877288821425346,"pubTatorScore":1.7979184598794475,"self":"https://pharos.nih.gov/idg/api/v1/targets(8147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/properties"},"_links":{"count":702,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(8147)/publications"},"_namespace":null},{"id":8148,"version":3,"created":1554913621000,"modified":1555038036000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha","accession":"Q06190","gene":"PPP2R3A","description":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2095781638140588,"antibodyCount":167,"monoclonalCount":1,"pubmedCount":null,"jensenScore":14.487672,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":37.730403124706974,"pubTatorScore":1.3520982181968162,"self":"https://pharos.nih.gov/idg/api/v1/targets(8148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8148)/publications"},"_namespace":null},{"id":8149,"version":3,"created":1554913625000,"modified":1555038037000,"deprecated":false,"name":"Interleukin-13","accession":"P35225","gene":"IL13","description":"Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3186140219192226,"antibodyCount":841,"monoclonalCount":372,"pubmedCount":null,"jensenScore":1913.915736,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.74134781491296,"pubTatorScore":3.2723431164977557,"self":"https://pharos.nih.gov/idg/api/v1/targets(8149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/properties"},"_links":{"count":1174,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/synonyms"},"_publications":{"count":582,"href":"https://pharos.nih.gov/idg/api/v1/targets(8149)/publications"},"_namespace":null},{"id":8150,"version":3,"created":1554913632000,"modified":1555038041000,"deprecated":false,"name":"Lysosome-associated membrane glycoprotein 1","accession":"P11279","gene":"LAMP1","description":"Acts as a receptor for Lassa virus protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9868887924034104,"antibodyCount":959,"monoclonalCount":575,"pubmedCount":null,"jensenScore":817.340423,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":47.07087463135219,"pubTatorScore":2.6706139268087163,"self":"https://pharos.nih.gov/idg/api/v1/targets(8150)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":560,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/properties"},"_links":{"count":1350,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8150)/publications"},"_namespace":null},{"id":8151,"version":3,"created":1554913638000,"modified":1555038043000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 11","accession":"O75078","gene":"ADAM11","description":"Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8315154512203015,"antibodyCount":103,"monoclonalCount":13,"pubmedCount":null,"jensenScore":6.875137,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.31341384333944,"pubTatorScore":1.2900442548201008,"self":"https://pharos.nih.gov/idg/api/v1/targets(8151)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/properties"},"_links":{"count":750,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8151)/publications"},"_namespace":null},{"id":8152,"version":3,"created":1554913642000,"modified":1555038044000,"deprecated":false,"name":"Catenin beta-1","accession":"P35222","gene":"CTNNB1","description":"Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.9994791590638146,"antibodyCount":3058,"monoclonalCount":1037,"pubmedCount":null,"jensenScore":9786.04604,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":69.2903951911649,"pubTatorScore":3.739476917807999,"self":"https://pharos.nih.gov/idg/api/v1/targets(8152)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2690,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/properties"},"_links":{"count":2577,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/synonyms"},"_publications":{"count":2024,"href":"https://pharos.nih.gov/idg/api/v1/targets(8152)/publications"},"_namespace":null},{"id":8153,"version":2,"created":1554913665000,"modified":1554913669000,"deprecated":false,"name":"Transcriptional repressor CTCFL","accession":"Q8NI51","gene":"CTCFL","description":"Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8063200826099042,"antibodyCount":164,"monoclonalCount":22,"pubmedCount":null,"jensenScore":44.763128,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.258292484185937,"pubTatorScore":2.0774292800225505,"self":"https://pharos.nih.gov/idg/api/v1/targets(8153)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/properties"},"_links":{"count":718,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/links"},"_synonyms":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8153)/publications"},"_namespace":null},{"id":8154,"version":3,"created":1554913670000,"modified":1555038053000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 23","accession":"O75077","gene":"ADAM23","description":"May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3382430477663663,"antibodyCount":193,"monoclonalCount":6,"pubmedCount":null,"jensenScore":20.953658,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.090229757824964,"pubTatorScore":1.3876837299934661,"self":"https://pharos.nih.gov/idg/api/v1/targets(8154)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8154)/publications"},"_namespace":null},{"id":8155,"version":3,"created":1554913674000,"modified":1554913826000,"deprecated":false,"name":"Nitric oxide synthase, inducible","accession":"P35228","gene":"NOS2","description":"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.351337552126681,"antibodyCount":752,"monoclonalCount":136,"pubmedCount":null,"jensenScore":2277.53404,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.781636578959684,"pubTatorScore":3.7354308593345156,"self":"https://pharos.nih.gov/idg/api/v1/targets(8155)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/properties"},"_links":{"count":1925,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/links"},"_synonyms":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/synonyms"},"_publications":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(8155)/publications"},"_namespace":null},{"id":8156,"version":2,"created":1554913830000,"modified":1554913832000,"deprecated":false,"name":"Low-density lipoprotein receptor-related protein 3","accession":"O75074","gene":"LRP3","description":"Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9160777649519216,"antibodyCount":125,"monoclonalCount":10,"pubmedCount":null,"jensenScore":7.517297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.107867737915406,"pubTatorScore":0.396357861811999,"self":"https://pharos.nih.gov/idg/api/v1/targets(8156)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8156)/publications"},"_namespace":null},{"id":8157,"version":3,"created":1554913832000,"modified":1555038054000,"deprecated":false,"name":"Polycomb group RING finger protein 2","accession":"P35227","gene":"PCGF2","description":"Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5918516533436717,"antibodyCount":189,"monoclonalCount":26,"pubmedCount":null,"jensenScore":43.843105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":36.45599816765431,"pubTatorScore":1.6098572432321652,"self":"https://pharos.nih.gov/idg/api/v1/targets(8157)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/properties"},"_links":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8157)/publications"},"_namespace":null},{"id":8158,"version":2,"created":1554913835000,"modified":1554913839000,"deprecated":false,"name":"Spectrin beta chain, erythrocytic","accession":"P11277","gene":"SPTB","description":"Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.459820739477726,"antibodyCount":59,"monoclonalCount":44,"pubmedCount":null,"jensenScore":275.05152,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.312552400992686,"pubTatorScore":2.197186268762998,"self":"https://pharos.nih.gov/idg/api/v1/targets(8158)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8158)/publications"},"_namespace":null},{"id":8159,"version":3,"created":1554913840000,"modified":1555038055000,"deprecated":false,"name":"Polycomb complex protein BMI-1","accession":"P35226","gene":"BMI1","description":"Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.865513703209966,"antibodyCount":666,"monoclonalCount":216,"pubmedCount":null,"jensenScore":758.093513,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.04188584120407,"pubTatorScore":2.818075745655795,"self":"https://pharos.nih.gov/idg/api/v1/targets(8159)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(8159)/properties"},"_links":{"count":1519,"href":"https://pharos.nih.gov/idg/api/v1/targets(8159)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8159)/synonyms"},"_publications":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(8159)/publications"},"_namespace":null},{"id":8160,"version":2,"created":1554913848000,"modified":1554913850000,"deprecated":false,"name":"Clathrin heavy chain linker domain-containing protein 1","accession":"Q8NHS4","gene":"CLHC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.4913616938342726,"antibodyCount":17,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.032258,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.67368537590018,"pubTatorScore":-1.505149978319906,"self":"https://pharos.nih.gov/idg/api/v1/targets(8160)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(8160)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(8160)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8160)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8160)/publications"},"_namespace":null},{"id":8161,"version":3,"created":1554913851000,"modified":1555038058000,"deprecated":false,"name":"WD repeat-containing protein 1","accession":"O75083","gene":"WDR1","description":"Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6354349348583268,"antibodyCount":103,"monoclonalCount":7,"pubmedCount":null,"jensenScore":45.286443,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.77625606056719,"pubTatorScore":1.3496551896964155,"self":"https://pharos.nih.gov/idg/api/v1/targets(8161)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(8161)/properties"},"_links":{"count":1200,"href":"https://pharos.nih.gov/idg/api/v1/targets(8161)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8161)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8161)/publications"},"_namespace":null},{"id":8162,"version":2,"created":1554913856000,"modified":1554913856000,"deprecated":false,"name":"Endogenous retrovirus group K member 25 Env polyprotein","accession":"P61570","gene":"ERVK-25","description":"TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8162)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8162)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8162)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8162)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8162)/publications"},"_namespace":null},{"id":8163,"version":2,"created":1554913856000,"modified":1554913857000,"deprecated":false,"name":"Olfactory receptor 5M10","accession":"Q6IEU7","gene":"OR5M10","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":86,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.828638426147702,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8163)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8163)/properties"},"_links":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(8163)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8163)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8163)/publications"},"_namespace":null},{"id":8164,"version":2,"created":1554913857000,"modified":1554913859000,"deprecated":false,"name":"IQ domain-containing protein G","accession":"Q9H095","gene":"IQCG","description":"Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3832167554704519,"antibodyCount":43,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.909599,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.420111461451587,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(8164)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(8164)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(8164)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8164)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8164)/publications"},"_namespace":null},{"id":8165,"version":2,"created":1554913860000,"modified":1554913864000,"deprecated":false,"name":"Frizzled-7","accession":"O75084","gene":"FZD7","description":"Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.8187330921082154,"antibodyCount":345,"monoclonalCount":62,"pubmedCount":null,"jensenScore":66.426201,"patentCount":12167,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.68030382634142,"pubTatorScore":1.5646138984468587,"self":"https://pharos.nih.gov/idg/api/v1/targets(8165)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(8165)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(8165)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8165)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8165)/publications"},"_namespace":null},{"id":8166,"version":2,"created":1554913865000,"modified":1554913868000,"deprecated":false,"name":"Protein FAM107B","accession":"Q9H098","gene":"FAM107B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2218487496163564,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.526878,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.88776060677626,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(8166)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(8166)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(8166)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(8166)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8166)/publications"},"_namespace":null},{"id":8167,"version":3,"created":1554913869000,"modified":1555038060000,"deprecated":false,"name":"Putative aspartate aminotransferase, cytoplasmic 2","accession":"Q8NHS2","gene":"GOT1L1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.3441448408011892,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.493723,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":18.31202713285049,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(8167)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8167)/properties"},"_links":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(8167)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8167)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8167)/publications"},"_namespace":null},{"id":8168,"version":2,"created":1554913870000,"modified":1554913874000,"deprecated":false,"name":"Protein CBFA2T3","accession":"O75081","gene":"CBFA2T3","description":"Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8014831193369056,"antibodyCount":82,"monoclonalCount":4,"pubmedCount":null,"jensenScore":64.915477,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.48351996314079,"pubTatorScore":1.7021007352091289,"self":"https://pharos.nih.gov/idg/api/v1/targets(8168)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(8168)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(8168)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8168)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8168)/publications"},"_namespace":null},{"id":8169,"version":3,"created":1554913875000,"modified":1555038060000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 8","accession":"Q8NHS3","gene":"MFSD8","description":"May be a carrier that transport small solutes by using chemiosmotic ion gradients.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8201338038469004,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":64.122406,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.880171524090102,"pubTatorScore":1.3174831853868527,"self":"https://pharos.nih.gov/idg/api/v1/targets(8169)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(8169)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(8169)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8169)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8169)/publications"},"_namespace":null},{"id":8170,"version":3,"created":1554913880000,"modified":1555038062000,"deprecated":false,"name":"Prohibitin","accession":"P35232","gene":"PHB","description":"Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.698611859103052,"antibodyCount":517,"monoclonalCount":110,"pubmedCount":null,"jensenScore":504.926928,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":52.02142332005666,"pubTatorScore":2.4815629386408227,"self":"https://pharos.nih.gov/idg/api/v1/targets(8170)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":613,"href":"https://pharos.nih.gov/idg/api/v1/targets(8170)/properties"},"_links":{"count":1286,"href":"https://pharos.nih.gov/idg/api/v1/targets(8170)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8170)/synonyms"},"_publications":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(8170)/publications"},"_namespace":null},{"id":8171,"version":2,"created":1554913885000,"modified":1554913885000,"deprecated":false,"name":"Endogenous retrovirus group K member 113 Rec protein","accession":"P61574","gene":"HERVK_113","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8171)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8171)/links"},"_synonyms":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8171)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8171)/publications"},"_namespace":null},{"id":8172,"version":2,"created":1554913885000,"modified":1554913887000,"deprecated":false,"name":"Zinc finger MYND domain-containing protein 15","accession":"Q9H091","gene":"ZMYND15","description":"Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2218487496163564,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.333334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.902148153935975,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(8172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(8172)/properties"},"_links":{"count":742,"href":"https://pharos.nih.gov/idg/api/v1/targets(8172)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8172)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8172)/publications"},"_namespace":null},{"id":8173,"version":3,"created":1554913888000,"modified":1555038064000,"deprecated":false,"name":"Spermatogenesis-associated protein 22","accession":"Q8NHS9","gene":"SPATA22","description":"Meiosis-specific protein required for homologous recombination in meiosis I.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6825979431073234,"antibodyCount":38,"monoclonalCount":9,"pubmedCount":null,"jensenScore":3.846808,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":18.896336647927534,"pubTatorScore":0.5006023962843915,"self":"https://pharos.nih.gov/idg/api/v1/targets(8173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(8173)/properties"},"_links":{"count":697,"href":"https://pharos.nih.gov/idg/api/v1/targets(8173)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8173)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8173)/publications"},"_namespace":null},{"id":8174,"version":2,"created":1554913891000,"modified":1554913891000,"deprecated":false,"name":"Endogenous retrovirus group K member 9 Rec protein","accession":"P61573","gene":"ERVK-9","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8174)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8174)/links"},"_synonyms":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8174)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8174)/publications"},"_namespace":null},{"id":8175,"version":3,"created":1554913891000,"modified":1555038064000,"deprecated":false,"name":"Neuroblastoma breakpoint family member 3","accession":"Q9H094","gene":"NBPF3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.17609125688420882,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.485714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.496045547697143,"pubTatorScore":1.5275531644382128,"self":"https://pharos.nih.gov/idg/api/v1/targets(8175)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(8175)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(8175)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8175)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8175)/publications"},"_namespace":null},{"id":8176,"version":2,"created":1554913893000,"modified":1554913893000,"deprecated":false,"name":"Endogenous retrovirus group K member 19 Rec protein","accession":"P61572","gene":"ERVK-19","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(8176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8176)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8176)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8176)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8176)/publications"},"_namespace":null},{"id":8177,"version":3,"created":1554913893000,"modified":1555038066000,"deprecated":false,"name":"NUAK family SNF1-like kinase 2","accession":"Q9H093","gene":"NUAK2","description":"Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.7025787430082282,"antibodyCount":210,"monoclonalCount":20,"pubmedCount":null,"jensenScore":54.256812,"patentCount":3314,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":33.371175375752614,"pubTatorScore":1.5797299807964653,"self":"https://pharos.nih.gov/idg/api/v1/targets(8177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(8177)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(8177)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8177)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8177)/publications"},"_namespace":null},{"id":8178,"version":2,"created":1554913899000,"modified":1554913899000,"deprecated":false,"name":"Endogenous retrovirus group K member 21 Rec protein","accession":"P61571","gene":"ERVK-21","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8178)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8178)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8178)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8178)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8178)/publications"},"_namespace":null},{"id":8179,"version":2,"created":1554913899000,"modified":1554913903000,"deprecated":false,"name":"Tubulin gamma-1 chain","accession":"P23258","gene":"TUBG1","description":"Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.326195120208486,"antibodyCount":339,"monoclonalCount":132,"pubmedCount":null,"jensenScore":20.638057,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.16884998872292,"pubTatorScore":1.240797673530809,"self":"https://pharos.nih.gov/idg/api/v1/targets(8179)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(8179)/properties"},"_links":{"count":1134,"href":"https://pharos.nih.gov/idg/api/v1/targets(8179)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8179)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8179)/publications"},"_namespace":null},{"id":8180,"version":2,"created":1554913904000,"modified":1554913904000,"deprecated":false,"name":"Endogenous retrovirus group K member 16 Rec protein","accession":"P61578","gene":"ERVK-16","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8180)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8180)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8180)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8180)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8180)/publications"},"_namespace":null},{"id":8181,"version":2,"created":1554913904000,"modified":1554913904000,"deprecated":false,"name":"Endogenous retrovirus group K member 104 Rec protein","accession":"P61576","gene":"HERV-K104","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8181)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8181)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8181)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8181)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8181)/publications"},"_namespace":null},{"id":8182,"version":2,"created":1554913904000,"modified":1554913908000,"deprecated":false,"name":"Granzyme K","accession":"P49863","gene":"GZMK","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0953336739459396,"antibodyCount":178,"monoclonalCount":52,"pubmedCount":null,"jensenScore":118.989119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.589114453487788,"pubTatorScore":1.5024996192599187,"self":"https://pharos.nih.gov/idg/api/v1/targets(8182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(8182)/properties"},"_links":{"count":739,"href":"https://pharos.nih.gov/idg/api/v1/targets(8182)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8182)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8182)/publications"},"_namespace":null},{"id":8183,"version":2,"created":1554913908000,"modified":1554913908000,"deprecated":false,"name":"Endogenous retrovirus group K member 8 Rec protein","accession":"P61575","gene":"ERVK-8","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8183)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8183)/links"},"_synonyms":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8183)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8183)/publications"},"_namespace":null},{"id":8184,"version":3,"created":1554913908000,"modified":1555038067000,"deprecated":false,"name":"Calmodulin regulator protein PCP4","accession":"P48539","gene":"PCP4","description":"Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed:21491429).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8504188182356387,"antibodyCount":51,"monoclonalCount":11,"pubmedCount":null,"jensenScore":83.928395,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.6670844594699,"pubTatorScore":1.5530410262059184,"self":"https://pharos.nih.gov/idg/api/v1/targets(8184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(8184)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(8184)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8184)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8184)/publications"},"_namespace":null},{"id":8185,"version":3,"created":1554913912000,"modified":1555038068000,"deprecated":false,"name":"A-kinase anchor protein 5","accession":"P24588","gene":"AKAP5","description":"May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0703139376210493,"antibodyCount":196,"monoclonalCount":26,"pubmedCount":null,"jensenScore":126.270759,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.853528775793418,"pubTatorScore":2.044713917535643,"self":"https://pharos.nih.gov/idg/api/v1/targets(8185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(8185)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(8185)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8185)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8185)/publications"},"_namespace":null},{"id":8186,"version":2,"created":1554913916000,"modified":1554913916000,"deprecated":false,"name":"Endogenous retrovirus group K member 25 Rec protein","accession":"P61579","gene":"ERVK-25","description":"Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8186)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8186)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8186)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8186)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8186)/publications"},"_namespace":null},{"id":8187,"version":3,"created":1554913916000,"modified":1555038069000,"deprecated":false,"name":"Intraflagellar transport protein 56","accession":"A0AVF1","gene":"TTC26","description":"Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6975199299787206,"antibodyCount":74,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.91749,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.115881689599725,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(8187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(8187)/properties"},"_links":{"count":909,"href":"https://pharos.nih.gov/idg/api/v1/targets(8187)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8187)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8187)/publications"},"_namespace":null},{"id":8188,"version":2,"created":1554913919000,"modified":1554913922000,"deprecated":false,"name":"RNA cytidine acetyltransferase","accession":"Q9H0A0","gene":"NAT10","description":"RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7976220415432531,"antibodyCount":125,"monoclonalCount":0,"pubmedCount":null,"jensenScore":61.520507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.99669376085376,"pubTatorScore":1.5811149180210453,"self":"https://pharos.nih.gov/idg/api/v1/targets(8188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(8188)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(8188)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8188)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8188)/publications"},"_namespace":null},{"id":8189,"version":2,"created":1554913923000,"modified":1554913926000,"deprecated":false,"name":"Receptor expression-enhancing protein 3","accession":"Q6NUK4","gene":"REEP3","description":"Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.347871863149804,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.173015,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.49615985940679,"pubTatorScore":0.15126747095672716,"self":"https://pharos.nih.gov/idg/api/v1/targets(8189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(8189)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(8189)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8189)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8189)/publications"},"_namespace":null},{"id":8190,"version":2,"created":1554913927000,"modified":1554913930000,"deprecated":false,"name":"Calcium-binding mitochondrial carrier protein SCaMC-1","accession":"Q6NUK1","gene":"SLC25A24","description":"Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.7650053562357797,"antibodyCount":69,"monoclonalCount":10,"pubmedCount":null,"jensenScore":6.304448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.16755846398931,"pubTatorScore":1.1437219679804285,"self":"https://pharos.nih.gov/idg/api/v1/targets(8190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(8190)/properties"},"_links":{"count":1046,"href":"https://pharos.nih.gov/idg/api/v1/targets(8190)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8190)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8190)/publications"},"_namespace":null},{"id":8191,"version":3,"created":1554913931000,"modified":1555038070000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 D2","accession":"P62837","gene":"UBE2D2","description":"Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.091462440029048,"antibodyCount":239,"monoclonalCount":58,"pubmedCount":null,"jensenScore":111.292648,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":44.11492410316467,"pubTatorScore":1.715260131314692,"self":"https://pharos.nih.gov/idg/api/v1/targets(8191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(8191)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(8191)/links"},"_synonyms":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(8191)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8191)/publications"},"_namespace":null},{"id":8192,"version":3,"created":1554913935000,"modified":1555038072000,"deprecated":false,"name":"Transmembrane and coiled-coil domains protein 2","accession":"O75069","gene":"TMCC2","description":"May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.535715963905387,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":33.782024937447794,"pubTatorScore":0.1856364825500575,"self":"https://pharos.nih.gov/idg/api/v1/targets(8192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(8192)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(8192)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8192)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8192)/publications"},"_namespace":null},{"id":8193,"version":2,"created":1554913939000,"modified":1554913944000,"deprecated":false,"name":"Lipopolysaccharide-responsive and beige-like anchor protein","accession":"P50851","gene":"LRBA","description":"May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.999565922520681,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":965.558513,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.33776478616443,"pubTatorScore":2.2222643199426844,"self":"https://pharos.nih.gov/idg/api/v1/targets(8193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(8193)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(8193)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8193)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8193)/publications"},"_namespace":null},{"id":8194,"version":3,"created":1554913945000,"modified":1555038073000,"deprecated":false,"name":"Glycosaminoglycan xylosylkinase","accession":"O75063","gene":"FAM20B","description":"Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7947203450128897,"antibodyCount":12,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.458921,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.77900466833884,"pubTatorScore":0.4445651687526213,"self":"https://pharos.nih.gov/idg/api/v1/targets(8194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(8194)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(8194)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8194)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8194)/publications"},"_namespace":null},{"id":8195,"version":4,"created":1554913951000,"modified":1555038075000,"deprecated":false,"name":"Tyrosine-protein kinase BTK","accession":"Q06187","gene":"BTK","description":"Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.0754467812108954,"antibodyCount":810,"monoclonalCount":233,"pubmedCount":null,"jensenScore":1199.458754,"patentCount":163605,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":48.342266659738364,"pubTatorScore":2.8797178415988003,"self":"https://pharos.nih.gov/idg/api/v1/targets(8195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":667,"href":"https://pharos.nih.gov/idg/api/v1/targets(8195)/properties"},"_links":{"count":1580,"href":"https://pharos.nih.gov/idg/api/v1/targets(8195)/links"},"_synonyms":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(8195)/synonyms"},"_publications":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(8195)/publications"},"_namespace":null},{"id":8196,"version":2,"created":1554914080000,"modified":1554914084000,"deprecated":false,"name":"DENN domain-containing protein 4B","accession":"O75064","gene":"DENND4B","description":"Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.837087073028666,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(8196)/properties"},"_links":{"count":981,"href":"https://pharos.nih.gov/idg/api/v1/targets(8196)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8196)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8196)/publications"},"_namespace":null},{"id":8197,"version":2,"created":1554914084000,"modified":1554914089000,"deprecated":false,"name":"Fukutin","accession":"O75072","gene":"FKTN","description":"Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.349935438822318,"antibodyCount":131,"monoclonalCount":1,"pubmedCount":null,"jensenScore":236.871358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.42968520827357,"pubTatorScore":2.2938243365644744,"self":"https://pharos.nih.gov/idg/api/v1/targets(8197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(8197)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8197)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8197)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8197)/publications"},"_namespace":null},{"id":8198,"version":2,"created":1554914090000,"modified":1554914093000,"deprecated":false,"name":"EF-hand calcium-binding domain-containing protein 14","accession":"O75071","gene":"EFCAB14","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.77186435094083,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(8198)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(8198)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8198)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8198)/publications"},"_namespace":null},{"id":8199,"version":3,"created":1554914094000,"modified":1555038078000,"deprecated":false,"name":"Ras-related protein Rap-1A","accession":"P62834","gene":"RAP1A","description":"Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.407990994862134,"antibodyCount":329,"monoclonalCount":120,"pubmedCount":null,"jensenScore":294.709434,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":52.67409026805074,"pubTatorScore":2.6517502230530208,"self":"https://pharos.nih.gov/idg/api/v1/targets(8199)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(8199)/properties"},"_links":{"count":1249,"href":"https://pharos.nih.gov/idg/api/v1/targets(8199)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8199)/synonyms"},"_publications":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(8199)/publications"},"_namespace":null},{"id":8200,"version":2,"created":1554914101000,"modified":1554914101000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 66","accession":"B4E2M5","gene":"ANKRD66","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.220723909833692,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8200)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8200)/properties"},"_links":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(8200)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8200)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8200)/publications"},"_namespace":null},{"id":8201,"version":2,"created":1554914102000,"modified":1554914105000,"deprecated":false,"name":"Syndecan-3","accession":"O75056","gene":"SDC3","description":"Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.861719727800514,"antibodyCount":179,"monoclonalCount":12,"pubmedCount":null,"jensenScore":78.847267,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.70943448854885,"pubTatorScore":1.609217359083455,"self":"https://pharos.nih.gov/idg/api/v1/targets(8201)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(8201)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(8201)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8201)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8201)/publications"},"_namespace":null},{"id":8202,"version":2,"created":1554914106000,"modified":1554914106000,"deprecated":false,"name":"Methyl-CpG-binding domain protein 3-like 2","accession":"Q8NHZ7","gene":"MBD3L2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.21307482386120297,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.457955,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.914756252608829,"pubTatorScore":0.30667502341848546,"self":"https://pharos.nih.gov/idg/api/v1/targets(8202)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8202)/properties"},"_links":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8202)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8202)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8202)/publications"},"_namespace":null},{"id":8203,"version":2,"created":1554914106000,"modified":1554914109000,"deprecated":false,"name":"Immunoglobulin superfamily member 3","accession":"O75054","gene":"IGSF3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5695326111371923,"antibodyCount":118,"monoclonalCount":46,"pubmedCount":null,"jensenScore":37.025102,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.74371663549731,"pubTatorScore":1.7290700691365501,"self":"https://pharos.nih.gov/idg/api/v1/targets(8203)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(8203)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(8203)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8203)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8203)/publications"},"_namespace":null},{"id":8204,"version":3,"created":1554914110000,"modified":1555038080000,"deprecated":false,"name":"Anaphase-promoting complex subunit CDC26","accession":"Q8NHZ8","gene":"CDC26","description":"Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7958800173440752,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.564762,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":32.096340242372236,"pubTatorScore":0.6372196624916939,"self":"https://pharos.nih.gov/idg/api/v1/targets(8204)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(8204)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(8204)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8204)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8204)/publications"},"_namespace":null},{"id":8205,"version":2,"created":1554914113000,"modified":1554914116000,"deprecated":false,"name":"Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein","accession":"O75052","gene":"NOS1AP","description":"Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1326161970232387,"antibodyCount":159,"monoclonalCount":6,"pubmedCount":null,"jensenScore":142.616033,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.61631539706941,"pubTatorScore":2.1475768609614714,"self":"https://pharos.nih.gov/idg/api/v1/targets(8205)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(8205)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(8205)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8205)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8205)/publications"},"_namespace":null},{"id":8206,"version":2,"created":1554914117000,"modified":1554914121000,"deprecated":false,"name":"Putative tyrosine-protein phosphatase auxilin","accession":"O75061","gene":"DNAJC6","description":"Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.74102934348973,"antibodyCount":98,"monoclonalCount":3,"pubmedCount":null,"jensenScore":58.715718,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.24215591492177,"pubTatorScore":1.5933196570701325,"self":"https://pharos.nih.gov/idg/api/v1/targets(8206)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(8206)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(8206)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8206)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8206)/publications"},"_namespace":null},{"id":8207,"version":2,"created":1554914122000,"modified":1554914122000,"deprecated":false,"name":"Putative uncharacterized protein ZNF252P-AS1","accession":"Q0IIN9","gene":"ZNF252P-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.201322867117627,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8207)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8207)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8207)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8207)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8207)/publications"},"_namespace":null},{"id":8208,"version":2,"created":1554914122000,"modified":1554914125000,"deprecated":false,"name":"40S ribosomal protein S24","accession":"P62847","gene":"RPS24","description":"Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9173183702590706,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":77.286266,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.94180906067789,"pubTatorScore":1.569901414951669,"self":"https://pharos.nih.gov/idg/api/v1/targets(8208)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(8208)/properties"},"_links":{"count":1169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8208)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(8208)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8208)/publications"},"_namespace":null},{"id":8209,"version":2,"created":1554914126000,"modified":1554914129000,"deprecated":false,"name":"40S ribosomal protein S15","accession":"P62841","gene":"RPS15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2224941562551055,"antibodyCount":149,"monoclonalCount":20,"pubmedCount":null,"jensenScore":154.831394,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.64860445302475,"pubTatorScore":1.7132337966582616,"self":"https://pharos.nih.gov/idg/api/v1/targets(8209)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(8209)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8209)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8209)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8209)/publications"},"_namespace":null},{"id":8210,"version":3,"created":1554914130000,"modified":1555038084000,"deprecated":false,"name":"60S ribosomal protein L37a","accession":"P61513","gene":"RPL37A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5028585121528357,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":31.562647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":94,"knowledgeAvailability":37.259469836113624,"pubTatorScore":0.8784985865516115,"self":"https://pharos.nih.gov/idg/api/v1/targets(8210)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(8210)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(8210)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8210)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8210)/publications"},"_namespace":null},{"id":8211,"version":2,"created":1554914134000,"modified":1554914135000,"deprecated":false,"name":"Putative coiled-coil domain-containing protein 144 N-terminal-like","accession":"Q6NUI1","gene":"CCDC144NL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.508394670155981,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8211)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(8211)/properties"},"_links":{"count":606,"href":"https://pharos.nih.gov/idg/api/v1/targets(8211)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8211)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8211)/publications"},"_namespace":null},{"id":8212,"version":3,"created":1554914136000,"modified":1555038085000,"deprecated":false,"name":"Glycerol-3-phosphate acyltransferase 2, mitochondrial","accession":"Q6NUI2","gene":"GPAT2","description":"Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.971585048247933,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.925719,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":24.388950063761854,"pubTatorScore":0.31875869313729016,"self":"https://pharos.nih.gov/idg/api/v1/targets(8212)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(8212)/properties"},"_links":{"count":785,"href":"https://pharos.nih.gov/idg/api/v1/targets(8212)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8212)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8212)/publications"},"_namespace":null},{"id":8213,"version":2,"created":1554914138000,"modified":1554914141000,"deprecated":false,"name":"Protein S100-A1","accession":"P23297","gene":"S100A1","description":"Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4738068045463084,"antibodyCount":704,"monoclonalCount":394,"pubmedCount":null,"jensenScore":296.00041,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.43025555497903,"pubTatorScore":2.9678325045282214,"self":"https://pharos.nih.gov/idg/api/v1/targets(8213)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(8213)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(8213)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8213)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8213)/publications"},"_namespace":null},{"id":8214,"version":3,"created":1554914142000,"modified":1555038086000,"deprecated":false,"name":"Serpin B4","accession":"P48594","gene":"SERPINB4","description":"May act as a protease inhibitor to modulate the host immune response against tumor cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9860232997300071,"antibodyCount":239,"monoclonalCount":71,"pubmedCount":null,"jensenScore":100.718453,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.659127218845914,"pubTatorScore":1.8054980036312978,"self":"https://pharos.nih.gov/idg/api/v1/targets(8214)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8214)/properties"},"_links":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(8214)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8214)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8214)/publications"},"_namespace":null},{"id":8215,"version":2,"created":1554914146000,"modified":1554914147000,"deprecated":false,"name":"Serpin B10","accession":"P48595","gene":"SERPINB10","description":"Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.025705278420613,"antibodyCount":101,"monoclonalCount":10,"pubmedCount":null,"jensenScore":100.559983,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.230247680921924,"pubTatorScore":1.4170452774580502,"self":"https://pharos.nih.gov/idg/api/v1/targets(8215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(8215)/properties"},"_links":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8215)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8215)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8215)/publications"},"_namespace":null},{"id":8216,"version":3,"created":1554914148000,"modified":1555038087000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RFWD2","accession":"Q8NHY2","gene":"COP1","description":"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5462292048932068,"antibodyCount":175,"monoclonalCount":22,"pubmedCount":null,"jensenScore":3.237252,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":0.0,"pubTatorScore":1.8520573940125438,"self":"https://pharos.nih.gov/idg/api/v1/targets(8216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(8216)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(8216)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8216)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8216)/publications"},"_namespace":null},{"id":8217,"version":2,"created":1554914152000,"modified":1554914152000,"deprecated":false,"name":"GAS2-like protein 2","accession":"Q8NHY3","gene":"GAS2L2","description":"Seems to be involved in the cross-linking of microtubules and microfilaments.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.15836249209524964,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.552941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.508124166322705,"pubTatorScore":-0.03778840296416235,"self":"https://pharos.nih.gov/idg/api/v1/targets(8217)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8217)/properties"},"_links":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(8217)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8217)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8217)/publications"},"_namespace":null},{"id":8218,"version":3,"created":1554914153000,"modified":1555038088000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF144A","accession":"P50876","gene":"RNF144A","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7395472208067262,"antibodyCount":155,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.536945,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.08495168106412,"pubTatorScore":0.3575115846524304,"self":"https://pharos.nih.gov/idg/api/v1/targets(8218)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(8218)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(8218)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8218)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8218)/publications"},"_namespace":null},{"id":8219,"version":2,"created":1554914156000,"modified":1554914157000,"deprecated":false,"name":"Olfactory receptor 4F3/4F16/4F29","accession":"Q6IEY1","gene":"OR4F16","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-0.09691001300805639,"antibodyCount":53,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.272727,"patentCount":2226,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2057565199208584,"pubTatorScore":2.405834027992573,"self":"https://pharos.nih.gov/idg/api/v1/targets(8219)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8219)/properties"},"_links":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8219)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8219)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8219)/publications"},"_namespace":null},{"id":8220,"version":2,"created":1554914157000,"modified":1554914159000,"deprecated":false,"name":"Beta-1,4 N-acetylgalactosaminyltransferase 2","accession":"Q8NHY0","gene":"B4GALNT2","description":"Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7713302158996607,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":584.73277,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.795632451859326,"pubTatorScore":1.1681680431747028,"self":"https://pharos.nih.gov/idg/api/v1/targets(8220)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(8220)/properties"},"_links":{"count":427,"href":"https://pharos.nih.gov/idg/api/v1/targets(8220)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8220)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8220)/publications"},"_namespace":null},{"id":8221,"version":2,"created":1554914159000,"modified":1554914162000,"deprecated":false,"name":"Zinc finger protein 28 homolog","accession":"Q8NHY6","gene":"ZFP28","description":"May be involved in transcriptional regulation. May have a role in embryonic development.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-1.2718415726615306,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":17.280409,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.19603691232182,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8221)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(8221)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(8221)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8221)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8221)/publications"},"_namespace":null},{"id":8222,"version":2,"created":1554914162000,"modified":1554914164000,"deprecated":false,"name":"SLIT-ROBO Rho GTPase-activating protein 2","accession":"O75044","gene":"SRGAP2","description":"RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0998453178813135,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.742738,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.20739998859101,"pubTatorScore":1.404186443500794,"self":"https://pharos.nih.gov/idg/api/v1/targets(8222)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(8222)/properties"},"_links":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(8222)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8222)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8222)/publications"},"_namespace":null},{"id":8223,"version":3,"created":1554914165000,"modified":1555038090000,"deprecated":false,"name":"Checkpoint protein HUS1B","accession":"Q8NHY5","gene":"HUS1B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.33243845904701635,"antibodyCount":70,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.781892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":17.915810052575306,"pubTatorScore":0.3806418844474239,"self":"https://pharos.nih.gov/idg/api/v1/targets(8223)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8223)/properties"},"_links":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(8223)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8223)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8223)/publications"},"_namespace":null},{"id":8224,"version":2,"created":1554914167000,"modified":1554914169000,"deprecated":false,"name":"Chondroadherin-like protein","accession":"Q6NUI6","gene":"CHADL","description":"Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4151721544173314,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.858766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.631756929947876,"pubTatorScore":0.09691001300805642,"self":"https://pharos.nih.gov/idg/api/v1/targets(8224)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(8224)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(8224)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8224)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8224)/publications"},"_namespace":null},{"id":8225,"version":3,"created":1554914170000,"modified":1555038092000,"deprecated":false,"name":"Two pore calcium channel protein 2","accession":"Q8NHX9","gene":"TPCN2","description":"Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.6704119677347027,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":46.033175,"patentCount":2158,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":50,"knowledgeAvailability":33.760867230396656,"pubTatorScore":1.5250013105904783,"self":"https://pharos.nih.gov/idg/api/v1/targets(8225)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(8225)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(8225)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8225)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8225)/publications"},"_namespace":null},{"id":8226,"version":2,"created":1554914173000,"modified":1554914175000,"deprecated":false,"name":"Angiopoietin-related protein 6","accession":"Q8NI99","gene":"ANGPTL6","description":"May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2183156975324527,"antibodyCount":139,"monoclonalCount":39,"pubmedCount":null,"jensenScore":163.462098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.23073277158145,"pubTatorScore":1.5774579166523435,"self":"https://pharos.nih.gov/idg/api/v1/targets(8226)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(8226)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(8226)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8226)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8226)/publications"},"_namespace":null},{"id":8227,"version":2,"created":1554914176000,"modified":1554914177000,"deprecated":false,"name":"Olfactory receptor 10K2","accession":"Q6IF99","gene":"OR10K2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":11,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.166667,"patentCount":356,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.82782322525953,"pubTatorScore":2.2314513823038116,"self":"https://pharos.nih.gov/idg/api/v1/targets(8227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8227)/properties"},"_links":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8227)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8227)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8227)/publications"},"_namespace":null},{"id":8228,"version":3,"created":1554914177000,"modified":1555038093000,"deprecated":false,"name":"Plexin-A2","accession":"O75051","gene":"PLXNA2","description":"Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4701283884864487,"antibodyCount":133,"monoclonalCount":50,"pubmedCount":null,"jensenScore":289.723556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":44.02886715698346,"pubTatorScore":3.2206210075644712,"self":"https://pharos.nih.gov/idg/api/v1/targets(8228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(8228)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(8228)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8228)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8228)/publications"},"_namespace":null},{"id":8229,"version":2,"created":1554914184000,"modified":1554914187000,"deprecated":false,"name":"TBC1 domain family member 8B","accession":"Q0IIM8","gene":"TBC1D8B","description":"May act as a GTPase-activating protein for Rab family protein(s).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.512754440508818,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(8229)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(8229)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8229)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8229)/publications"},"_namespace":null},{"id":8230,"version":2,"created":1554914188000,"modified":1554914191000,"deprecated":false,"name":"40S ribosomal protein S28","accession":"P62857","gene":"RPS28","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1792120806396205,"antibodyCount":44,"monoclonalCount":9,"pubmedCount":null,"jensenScore":14.198241,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.10350280224964,"pubTatorScore":0.8042097182661859,"self":"https://pharos.nih.gov/idg/api/v1/targets(8230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(8230)/properties"},"_links":{"count":1148,"href":"https://pharos.nih.gov/idg/api/v1/targets(8230)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8230)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8230)/publications"},"_namespace":null},{"id":8231,"version":2,"created":1554914192000,"modified":1554914195000,"deprecated":false,"name":"40S ribosomal protein S25","accession":"P62851","gene":"RPS25","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7130334104393183,"antibodyCount":154,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.562957,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.51655557843839,"pubTatorScore":1.427453730553581,"self":"https://pharos.nih.gov/idg/api/v1/targets(8231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(8231)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8231)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8231)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8231)/publications"},"_namespace":null},{"id":8232,"version":2,"created":1554914196000,"modified":1554914199000,"deprecated":false,"name":"40S ribosomal protein S26","accession":"P62854","gene":"RPS26","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5819406217111844,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":37.075633,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.48142085765074,"pubTatorScore":1.5177762106286528,"self":"https://pharos.nih.gov/idg/api/v1/targets(8232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(8232)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(8232)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8232)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8232)/publications"},"_namespace":null},{"id":8233,"version":2,"created":1554914200000,"modified":1554914202000,"deprecated":false,"name":"PWWP domain-containing protein 2B","accession":"Q6NUJ5","gene":"PWWP2B","description":null,"idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":null,"antibodyCount":48,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.199850123729192,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8233)/properties"},"_links":{"count":775,"href":"https://pharos.nih.gov/idg/api/v1/targets(8233)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8233)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8233)/publications"},"_namespace":null},{"id":8234,"version":3,"created":1554914203000,"modified":1555038096000,"deprecated":false,"name":"Uncharacterized protein C11orf87","accession":"Q6NUJ2","gene":"C11orf87","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":21,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":36,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(8234)/properties"},"_links":{"count":625,"href":"https://pharos.nih.gov/idg/api/v1/targets(8234)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8234)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8234)/publications"},"_namespace":null},{"id":8235,"version":2,"created":1554914205000,"modified":1554914207000,"deprecated":false,"name":"Proactivator polypeptide-like 1","accession":"Q6NUJ1","gene":"PSAPL1","description":"May activate the lysosomal degradation of sphingolipids.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":75,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.427078055875715,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8235)/properties"},"_links":{"count":731,"href":"https://pharos.nih.gov/idg/api/v1/targets(8235)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8235)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8235)/publications"},"_namespace":null},{"id":8236,"version":2,"created":1554914208000,"modified":1554914211000,"deprecated":false,"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2","accession":"O75038","gene":"PLCH2","description":"The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8017817996482479,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.810434,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.96523758913121,"pubTatorScore":0.8886340572180665,"self":"https://pharos.nih.gov/idg/api/v1/targets(8236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(8236)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(8236)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8236)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8236)/publications"},"_namespace":null},{"id":8237,"version":3,"created":1554914211000,"modified":1555038096000,"deprecated":false,"name":"General transcription factor IIF subunit 1","accession":"P35269","gene":"GTF2F1","description":"TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5987254573616383,"antibodyCount":176,"monoclonalCount":37,"pubmedCount":null,"jensenScore":42.500331,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.0313236453541,"pubTatorScore":1.8122774316006336,"self":"https://pharos.nih.gov/idg/api/v1/targets(8237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(8237)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(8237)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(8237)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8237)/publications"},"_namespace":null},{"id":8238,"version":2,"created":1554914215000,"modified":1554914219000,"deprecated":false,"name":"Kinesin-like protein KIF21B","accession":"O75037","gene":"KIF21B","description":"Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.040410406478302,"antibodyCount":41,"monoclonalCount":3,"pubmedCount":null,"jensenScore":10.973656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.14899424687892,"pubTatorScore":1.0218780813299364,"self":"https://pharos.nih.gov/idg/api/v1/targets(8238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(8238)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8238)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8238)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8238)/publications"},"_namespace":null},{"id":8239,"version":2,"created":1554914220000,"modified":1554914222000,"deprecated":false,"name":"60S ribosomal protein L22","accession":"P35268","gene":"RPL22","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1426307107336893,"antibodyCount":143,"monoclonalCount":0,"pubmedCount":null,"jensenScore":133.466613,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.19921881471043,"pubTatorScore":1.9749835415931727,"self":"https://pharos.nih.gov/idg/api/v1/targets(8239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(8239)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(8239)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8239)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8239)/publications"},"_namespace":null},{"id":8240,"version":2,"created":1554914223000,"modified":1554914224000,"deprecated":false,"name":"Olfactory receptor 2T5","accession":"Q6IEZ7","gene":"OR2T5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":57,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.090909,"patentCount":105,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.14527701580705,"pubTatorScore":1.1097472377132287,"self":"https://pharos.nih.gov/idg/api/v1/targets(8240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8240)/properties"},"_links":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8240)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8240)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8240)/publications"},"_namespace":null},{"id":8241,"version":3,"created":1554914224000,"modified":1555038098000,"deprecated":false,"name":"Microphthalmia-associated transcription factor","accession":"O75030","gene":"MITF","description":"Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.0908238771240635,"antibodyCount":549,"monoclonalCount":223,"pubmedCount":null,"jensenScore":1244.101828,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":54.63063316208252,"pubTatorScore":2.6526264550440217,"self":"https://pharos.nih.gov/idg/api/v1/targets(8241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":626,"href":"https://pharos.nih.gov/idg/api/v1/targets(8241)/properties"},"_links":{"count":1307,"href":"https://pharos.nih.gov/idg/api/v1/targets(8241)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(8241)/synonyms"},"_publications":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(8241)/publications"},"_namespace":null},{"id":8242,"version":2,"created":1554914231000,"modified":1554914233000,"deprecated":false,"name":"Heat shock factor 2-binding protein","accession":"O75031","gene":"HSF2BP","description":"May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.21085336205768454,"antibodyCount":71,"monoclonalCount":21,"pubmedCount":null,"jensenScore":1.433333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.0619535220005,"pubTatorScore":0.04139268515822508,"self":"https://pharos.nih.gov/idg/api/v1/targets(8242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(8242)/properties"},"_links":{"count":737,"href":"https://pharos.nih.gov/idg/api/v1/targets(8242)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8242)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8242)/publications"},"_namespace":null},{"id":8243,"version":2,"created":1554914234000,"modified":1554914235000,"deprecated":false,"name":"Spermatogenesis-associated protein 3","accession":"Q8NHX4","gene":"SPATA3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.39814242620766155,"antibodyCount":29,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.596403,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.260389113020551,"pubTatorScore":0.02996339709520122,"self":"https://pharos.nih.gov/idg/api/v1/targets(8243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(8243)/properties"},"_links":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8243)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8243)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8243)/publications"},"_namespace":null},{"id":8244,"version":2,"created":1554914235000,"modified":1554914236000,"deprecated":false,"name":"Otospiralin","accession":"Q8NHW6","gene":"OTOS","description":"May be essential for the survival of the neurosensory epithelium of the inner ear.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.5022138113158396,"antibodyCount":29,"monoclonalCount":4,"pubmedCount":null,"jensenScore":28.994643,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.056450995374957,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(8244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8244)/properties"},"_links":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(8244)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8244)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8244)/publications"},"_namespace":null},{"id":8245,"version":2,"created":1554914236000,"modified":1554914239000,"deprecated":false,"name":"Sepiapterin reductase","accession":"P35270","gene":"SPR","description":"Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5881426754069277,"antibodyCount":174,"monoclonalCount":55,"pubmedCount":null,"jensenScore":36.924622,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.760650176033124,"pubTatorScore":2.848083939077557,"self":"https://pharos.nih.gov/idg/api/v1/targets(8245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(8245)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(8245)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8245)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8245)/publications"},"_namespace":null},{"id":8246,"version":2,"created":1554914240000,"modified":1554914242000,"deprecated":false,"name":"40S ribosomal protein S30","accession":"P62861","gene":"FAU","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.152826038349796,"antibodyCount":284,"monoclonalCount":12,"pubmedCount":null,"jensenScore":258.843377,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.125996647874074,"self":"https://pharos.nih.gov/idg/api/v1/targets(8246)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(8246)/properties"},"_links":{"count":1009,"href":"https://pharos.nih.gov/idg/api/v1/targets(8246)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8246)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8246)/publications"},"_namespace":null},{"id":8247,"version":2,"created":1554914243000,"modified":1554914250000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 19","accession":"Q56UN5","gene":"MAP3K19","description":null,"idgFamily":"Kinase","idgTDL":"Tchem","novelty":0.07525095271530231,"antibodyCount":33,"monoclonalCount":7,"pubmedCount":null,"jensenScore":1.740909,"patentCount":2566,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.262057777346218,"pubTatorScore":1.7192708130685754,"self":"https://pharos.nih.gov/idg/api/v1/targets(8247)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(8247)/properties"},"_links":{"count":724,"href":"https://pharos.nih.gov/idg/api/v1/targets(8247)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8247)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8247)/publications"},"_namespace":null},{"id":8248,"version":3,"created":1554914251000,"modified":1555038101000,"deprecated":false,"name":"Myelin proteolipid protein","accession":"P60201","gene":"PLP1","description":"This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7881322393433354,"antibodyCount":191,"monoclonalCount":86,"pubmedCount":null,"jensenScore":591.054839,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":31.031385296450328,"pubTatorScore":2.858226133753382,"self":"https://pharos.nih.gov/idg/api/v1/targets(8248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(8248)/properties"},"_links":{"count":1068,"href":"https://pharos.nih.gov/idg/api/v1/targets(8248)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8248)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(8248)/publications"},"_namespace":null},{"id":8249,"version":2,"created":1554914257000,"modified":1554914259000,"deprecated":false,"name":"Immunoglobulin heavy constant delta","accession":"P01880","gene":"IGHD","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:10702483, PubMed:11282392).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.286884683999993,"pubTatorScore":0.5777835293422628,"self":"https://pharos.nih.gov/idg/api/v1/targets(8249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(8249)/properties"},"_links":{"count":576,"href":"https://pharos.nih.gov/idg/api/v1/targets(8249)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8249)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8249)/publications"},"_namespace":null},{"id":8250,"version":3,"created":1554914260000,"modified":1555038103000,"deprecated":false,"name":"Zinc finger protein 76","accession":"P36508","gene":"ZNF76","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.5264639829753693,"antibodyCount":100,"monoclonalCount":18,"pubmedCount":null,"jensenScore":3.35913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.24180810677064,"pubTatorScore":0.6070652701418026,"self":"https://pharos.nih.gov/idg/api/v1/targets(8250)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(8250)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(8250)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8250)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8250)/publications"},"_namespace":null},{"id":8251,"version":3,"created":1554914262000,"modified":1555038105000,"deprecated":false,"name":"Dual specificity mitogen-activated protein kinase kinase 2","accession":"P36507","gene":"MAP2K2","description":"Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-1.837436788236484,"antibodyCount":883,"monoclonalCount":197,"pubmedCount":null,"jensenScore":60.873522,"patentCount":23171,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":55.85166404128769,"pubTatorScore":2.0357482694089573,"self":"https://pharos.nih.gov/idg/api/v1/targets(8251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":825,"href":"https://pharos.nih.gov/idg/api/v1/targets(8251)/properties"},"_links":{"count":1377,"href":"https://pharos.nih.gov/idg/api/v1/targets(8251)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8251)/synonyms"},"_publications":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8251)/publications"},"_namespace":null},{"id":8252,"version":3,"created":1554914273000,"modified":1555038107000,"deprecated":false,"name":"Transaldolase","accession":"P37837","gene":"TALDO1","description":"Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.581049410183645,"antibodyCount":158,"monoclonalCount":12,"pubmedCount":null,"jensenScore":380.187922,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":42.63216224434198,"pubTatorScore":2.2412350889165378,"self":"https://pharos.nih.gov/idg/api/v1/targets(8252)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(8252)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(8252)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8252)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8252)/publications"},"_namespace":null},{"id":8253,"version":3,"created":1554914278000,"modified":1555038108000,"deprecated":false,"name":"Huntingtin-interacting protein 1-related protein","accession":"O75146","gene":"HIP1R","description":"Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5291610127260458,"antibodyCount":195,"monoclonalCount":24,"pubmedCount":null,"jensenScore":38.56106,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":41.375010483810996,"pubTatorScore":1.7536034863381174,"self":"https://pharos.nih.gov/idg/api/v1/targets(8253)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(8253)/properties"},"_links":{"count":1134,"href":"https://pharos.nih.gov/idg/api/v1/targets(8253)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8253)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8253)/publications"},"_namespace":null},{"id":8254,"version":3,"created":1554914282000,"modified":1554914510000,"deprecated":false,"name":"Sodium/glucose cotransporter 1","accession":"P13866","gene":"SLC5A1","description":"Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.862013267276468,"antibodyCount":244,"monoclonalCount":0,"pubmedCount":null,"jensenScore":723.33282,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.867851932193446,"pubTatorScore":2.507298572066157,"self":"https://pharos.nih.gov/idg/api/v1/targets(8254)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(8254)/properties"},"_links":{"count":1562,"href":"https://pharos.nih.gov/idg/api/v1/targets(8254)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8254)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8254)/publications"},"_namespace":null},{"id":8255,"version":3,"created":1554914512000,"modified":1555038110000,"deprecated":false,"name":"Testis-specific Y-encoded-like protein 1","accession":"Q9H0U9","gene":"TSPYL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9091982023441301,"antibodyCount":92,"monoclonalCount":10,"pubmedCount":null,"jensenScore":7.419783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":32.400222454954324,"pubTatorScore":0.979291864919243,"self":"https://pharos.nih.gov/idg/api/v1/targets(8255)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(8255)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(8255)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8255)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8255)/publications"},"_namespace":null},{"id":8256,"version":3,"created":1554914517000,"modified":1555038112000,"deprecated":false,"name":"Obscurin-like protein 1","accession":"O75147","gene":"OBSL1","description":"Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.448614297008616,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":27.330438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.42283822622229,"pubTatorScore":1.1320156025403283,"self":"https://pharos.nih.gov/idg/api/v1/targets(8256)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(8256)/properties"},"_links":{"count":1153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8256)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8256)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8256)/publications"},"_namespace":null},{"id":8257,"version":3,"created":1554914523000,"modified":1555038113000,"deprecated":false,"name":"Stathmin-4","accession":"Q9H169","gene":"STMN4","description":"Exhibits microtubule-destabilizing activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.061307692072697,"antibodyCount":106,"monoclonalCount":1,"pubmedCount":null,"jensenScore":113.064598,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":24.531693076644917,"pubTatorScore":1.6220412243834015,"self":"https://pharos.nih.gov/idg/api/v1/targets(8257)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(8257)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(8257)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8257)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8257)/publications"},"_namespace":null},{"id":8258,"version":3,"created":1554914526000,"modified":1555038115000,"deprecated":false,"name":"ICOS ligand","accession":"O75144","gene":"ICOSLG","description":"Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1452441042562924,"antibodyCount":496,"monoclonalCount":311,"pubmedCount":null,"jensenScore":153.204097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":32.11073392738824,"pubTatorScore":1.8159551615021365,"self":"https://pharos.nih.gov/idg/api/v1/targets(8258)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(8258)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(8258)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8258)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8258)/publications"},"_namespace":null},{"id":8259,"version":3,"created":1554914529000,"modified":1555038116000,"deprecated":false,"name":"Liprin-alpha-3","accession":"O75145","gene":"PPFIA3","description":"May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.4404592696139376,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.766684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.71580117441302,"pubTatorScore":0.6709964036836158,"self":"https://pharos.nih.gov/idg/api/v1/targets(8259)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(8259)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(8259)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8259)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8259)/publications"},"_namespace":null},{"id":8260,"version":3,"created":1554914533000,"modified":1555038117000,"deprecated":false,"name":"39S ribosomal protein L18, mitochondrial","accession":"Q9H0U6","gene":"MRPL18","description":"Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.17609125688420882,"antibodyCount":74,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.2,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":66,"knowledgeAvailability":32.850344712052575,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(8260)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8260)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8260)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8260)/publications"},"_namespace":null},{"id":8261,"version":3,"created":1554914536000,"modified":1555038119000,"deprecated":false,"name":"Autophagy-related protein 13","accession":"O75143","gene":"ATG13","description":"Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5403210929882571,"antibodyCount":400,"monoclonalCount":47,"pubmedCount":null,"jensenScore":28.768206,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.02684640232458,"pubTatorScore":1.2656748029406568,"self":"https://pharos.nih.gov/idg/api/v1/targets(8261)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(8261)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(8261)/links"},"_synonyms":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8261)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8261)/publications"},"_namespace":null},{"id":8262,"version":2,"created":1554914540000,"modified":1554914544000,"deprecated":false,"name":"B-cell lymphoma/leukemia 11A","accession":"Q9H165","gene":"BCL11A","description":"Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.162703293520622,"antibodyCount":300,"monoclonalCount":47,"pubmedCount":null,"jensenScore":150.955494,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.52352842441265,"pubTatorScore":2.14111466042284,"self":"https://pharos.nih.gov/idg/api/v1/targets(8262)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(8262)/properties"},"_links":{"count":1114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8262)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8262)/synonyms"},"_publications":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8262)/publications"},"_namespace":null},{"id":8263,"version":3,"created":1554914546000,"modified":1555038120000,"deprecated":false,"name":"GATOR complex protein DEPDC5","accession":"O75140","gene":"DEPDC5","description":"As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.590716099629789,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":33.682245,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":38.90575931408116,"pubTatorScore":1.4943097152317837,"self":"https://pharos.nih.gov/idg/api/v1/targets(8263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(8263)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(8263)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8263)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8263)/publications"},"_namespace":null},{"id":8264,"version":3,"created":1554914550000,"modified":1555038121000,"deprecated":false,"name":"Creatine kinase U-type, mitochondrial","accession":"P12532","gene":"CKMT1A","description":"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.9325835577762256,"antibodyCount":160,"monoclonalCount":51,"pubmedCount":null,"jensenScore":79.216302,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":19.637007389309073,"pubTatorScore":0.7865147665338947,"self":"https://pharos.nih.gov/idg/api/v1/targets(8264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(8264)/properties"},"_links":{"count":1643,"href":"https://pharos.nih.gov/idg/api/v1/targets(8264)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8264)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8264)/publications"},"_namespace":null},{"id":8265,"version":3,"created":1554914555000,"modified":1555038123000,"deprecated":false,"name":"cAMP-dependent protein kinase type II-alpha regulatory subunit","accession":"P13861","gene":"PRKAR2A","description":"Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9123104891946976,"antibodyCount":281,"monoclonalCount":149,"pubmedCount":null,"jensenScore":7.296958,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.966830547413565,"pubTatorScore":0.8191519724517332,"self":"https://pharos.nih.gov/idg/api/v1/targets(8265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(8265)/properties"},"_links":{"count":1065,"href":"https://pharos.nih.gov/idg/api/v1/targets(8265)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(8265)/synonyms"},"_publications":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8265)/publications"},"_namespace":null},{"id":8266,"version":3,"created":1554914559000,"modified":1555038125000,"deprecated":false,"name":"E3 ubiquitin-protein ligase BRE1B","accession":"O75150","gene":"RNF40","description":"Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9132299192713876,"antibodyCount":194,"monoclonalCount":11,"pubmedCount":null,"jensenScore":6.22054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.77329637745703,"pubTatorScore":1.0522235028585623,"self":"https://pharos.nih.gov/idg/api/v1/targets(8266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(8266)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8266)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8266)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8266)/publications"},"_namespace":null},{"id":8267,"version":2,"created":1554914565000,"modified":1554914568000,"deprecated":false,"name":"Homeobox protein aristaless-like 4","accession":"Q9H161","gene":"ALX4","description":"Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7776154878798112,"antibodyCount":213,"monoclonalCount":75,"pubmedCount":null,"jensenScore":62.748309,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.494751938277595,"pubTatorScore":1.629454412718771,"self":"https://pharos.nih.gov/idg/api/v1/targets(8267)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8267)/properties"},"_links":{"count":728,"href":"https://pharos.nih.gov/idg/api/v1/targets(8267)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8267)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8267)/publications"},"_namespace":null},{"id":8268,"version":3,"created":1554914569000,"modified":1555038126000,"deprecated":false,"name":"Ras-related protein Rab-1B","accession":"Q9H0U4","gene":"RAB1B","description":"The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3533917231782988,"antibodyCount":146,"monoclonalCount":29,"pubmedCount":null,"jensenScore":37.312299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":42.72315606573525,"pubTatorScore":1.464254079310457,"self":"https://pharos.nih.gov/idg/api/v1/targets(8268)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(8268)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8268)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8268)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8268)/publications"},"_namespace":null},{"id":8269,"version":2,"created":1554914573000,"modified":1554914576000,"deprecated":false,"name":"Magnesium transporter protein 1","accession":"Q9H0U3","gene":"MAGT1","description":"May be involved in Mg(2+) transport in epithelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6022429546985315,"antibodyCount":86,"monoclonalCount":0,"pubmedCount":null,"jensenScore":37.484651,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.0639558947259,"pubTatorScore":1.7374783081390084,"self":"https://pharos.nih.gov/idg/api/v1/targets(8269)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(8269)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(8269)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8269)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8269)/publications"},"_namespace":null},{"id":8270,"version":2,"created":1554914577000,"modified":1554914580000,"deprecated":false,"name":"BCLAF1 and THRAP3 family member 3","accession":"A2AJT9","gene":"BCLAF3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8270)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8270)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(8270)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8270)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8270)/publications"},"_namespace":null},{"id":8271,"version":2,"created":1554914580000,"modified":1554914583000,"deprecated":false,"name":"Talanin","accession":"Q70YC4","gene":"ZNF365","description":"May play a role in uric acid excretion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4401454216360652,"antibodyCount":273,"monoclonalCount":165,"pubmedCount":null,"jensenScore":50.559335,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.4043461612199246,"self":"https://pharos.nih.gov/idg/api/v1/targets(8271)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(8271)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(8271)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8271)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8271)/publications"},"_namespace":null},{"id":8272,"version":3,"created":1554914584000,"modified":1555038129000,"deprecated":false,"name":"Inhibitor of growth protein 2","accession":"Q9H160","gene":"ING2","description":"Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.5011522185673594,"antibodyCount":226,"monoclonalCount":85,"pubmedCount":null,"jensenScore":34.959378,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":40.34477086204389,"pubTatorScore":2.9179931044028176,"self":"https://pharos.nih.gov/idg/api/v1/targets(8272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(8272)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(8272)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8272)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8272)/publications"},"_namespace":null},{"id":8273,"version":2,"created":1554914590000,"modified":1554914591000,"deprecated":false,"name":"Protein ZNF365","accession":"Q70YC5","gene":"ZNF365","description":"Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4401454216360652,"antibodyCount":273,"monoclonalCount":165,"pubmedCount":null,"jensenScore":50.559335,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.69405197391399,"pubTatorScore":1.4043461612199246,"self":"https://pharos.nih.gov/idg/api/v1/targets(8273)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8273)/properties"},"_links":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(8273)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8273)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(8273)/publications"},"_namespace":null},{"id":8274,"version":2,"created":1554914591000,"modified":1554914593000,"deprecated":false,"name":"Immunoglobulin heavy constant alpha 2","accession":"P01877","gene":"IGHA2","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.146693413571306,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8274)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(8274)/properties"},"_links":{"count":591,"href":"https://pharos.nih.gov/idg/api/v1/targets(8274)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8274)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8274)/publications"},"_namespace":null},{"id":8275,"version":3,"created":1554914593000,"modified":1555038130000,"deprecated":false,"name":"Presenilin-2","accession":"P49810","gene":"PSEN2","description":"Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.7885563954614767,"antibodyCount":310,"monoclonalCount":85,"pubmedCount":null,"jensenScore":585.927492,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.24468798002001,"pubTatorScore":2.568449082914203,"self":"https://pharos.nih.gov/idg/api/v1/targets(8275)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(8275)/properties"},"_links":{"count":1200,"href":"https://pharos.nih.gov/idg/api/v1/targets(8275)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8275)/synonyms"},"_publications":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(8275)/publications"},"_namespace":null},{"id":8276,"version":2,"created":1554914603000,"modified":1554914606000,"deprecated":false,"name":"Immunoglobulin heavy constant alpha 1","accession":"P01876","gene":"IGHA1","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.589450788520157,"pubTatorScore":1.1687920203141817,"self":"https://pharos.nih.gov/idg/api/v1/targets(8276)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8276)/properties"},"_links":{"count":613,"href":"https://pharos.nih.gov/idg/api/v1/targets(8276)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8276)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8276)/publications"},"_namespace":null},{"id":8277,"version":3,"created":1554914606000,"modified":1555038132000,"deprecated":false,"name":"Tuberin","accession":"P49815","gene":"TSC2","description":"In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9938078849767242,"antibodyCount":1632,"monoclonalCount":112,"pubmedCount":null,"jensenScore":1000.616372,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":61.396028727827826,"pubTatorScore":2.7907186388888805,"self":"https://pharos.nih.gov/idg/api/v1/targets(8277)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(8277)/properties"},"_links":{"count":1473,"href":"https://pharos.nih.gov/idg/api/v1/targets(8277)/links"},"_synonyms":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(8277)/synonyms"},"_publications":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(8277)/publications"},"_namespace":null},{"id":8278,"version":2,"created":1554914614000,"modified":1554914616000,"deprecated":false,"name":"Uncharacterized protein C5orf49","accession":"A4QMS7","gene":"C5orf49","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8278)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(8278)/properties"},"_links":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(8278)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8278)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8278)/publications"},"_namespace":null},{"id":8279,"version":2,"created":1554914617000,"modified":1554914620000,"deprecated":false,"name":"Immunoglobulin heavy constant mu","accession":"P01871","gene":"IGHM","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.272693946786468,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(8279)/properties"},"_links":{"count":670,"href":"https://pharos.nih.gov/idg/api/v1/targets(8279)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8279)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8279)/publications"},"_namespace":null},{"id":8280,"version":3,"created":1554914620000,"modified":1555038134000,"deprecated":false,"name":"Proto-oncogene serine/threonine-protein kinase mos","accession":"P00540","gene":"MOS","description":null,"idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.1484851263029792,"antibodyCount":250,"monoclonalCount":37,"pubmedCount":null,"jensenScore":11.453607,"patentCount":27926,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":26.217651171842252,"pubTatorScore":2.713720107427416,"self":"https://pharos.nih.gov/idg/api/v1/targets(8280)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(8280)/properties"},"_links":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(8280)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8280)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8280)/publications"},"_namespace":null},{"id":8281,"version":2,"created":1554914622000,"modified":1554914654000,"deprecated":false,"name":"Glycogen phosphorylase, muscle form","accession":"P11217","gene":"PYGM","description":"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.243236132136502,"antibodyCount":208,"monoclonalCount":29,"pubmedCount":null,"jensenScore":158.21233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.005486615570355,"pubTatorScore":2.4770935979664546,"self":"https://pharos.nih.gov/idg/api/v1/targets(8281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(8281)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(8281)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(8281)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8281)/publications"},"_namespace":null},{"id":8282,"version":3,"created":1554914655000,"modified":1555038135000,"deprecated":false,"name":"Histone H4","accession":"P62805","gene":"HIST2H4A","description":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6743673638018217,"antibodyCount":913,"monoclonalCount":185,"pubmedCount":null,"jensenScore":144.496298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":19.234601009727253,"pubTatorScore":1.6152609434228642,"self":"https://pharos.nih.gov/idg/api/v1/targets(8282)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":650,"href":"https://pharos.nih.gov/idg/api/v1/targets(8282)/properties"},"_links":{"count":4999,"href":"https://pharos.nih.gov/idg/api/v1/targets(8282)/links"},"_synonyms":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(8282)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8282)/publications"},"_namespace":null},{"id":8283,"version":2,"created":1554914675000,"modified":1554914681000,"deprecated":false,"name":"Histone H2B type 1-C/E/F/G/I","accession":"P62807","gene":"HIST1H2BC","description":"Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.381654696423115,"antibodyCount":117,"monoclonalCount":12,"pubmedCount":null,"jensenScore":22.664941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.5675331334768,"pubTatorScore":0.3207395550311959,"self":"https://pharos.nih.gov/idg/api/v1/targets(8283)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":513,"href":"https://pharos.nih.gov/idg/api/v1/targets(8283)/properties"},"_links":{"count":1869,"href":"https://pharos.nih.gov/idg/api/v1/targets(8283)/links"},"_synonyms":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(8283)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8283)/publications"},"_namespace":null},{"id":8284,"version":3,"created":1554914683000,"modified":1555038142000,"deprecated":false,"name":"Cadherin-19","accession":"Q9H159","gene":"CDH19","description":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5990485484666234,"antibodyCount":140,"monoclonalCount":19,"pubmedCount":null,"jensenScore":4.172386,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":25.558113306209485,"pubTatorScore":0.8703480638271835,"self":"https://pharos.nih.gov/idg/api/v1/targets(8284)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(8284)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(8284)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8284)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8284)/publications"},"_namespace":null},{"id":8285,"version":3,"created":1554914688000,"modified":1555038143000,"deprecated":false,"name":"Protocadherin alpha-C1","accession":"Q9H158","gene":"PCDHAC1","description":"Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.24522226916872158,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.701681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":22.355991175890246,"pubTatorScore":-0.6455265994141876,"self":"https://pharos.nih.gov/idg/api/v1/targets(8285)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(8285)/properties"},"_links":{"count":647,"href":"https://pharos.nih.gov/idg/api/v1/targets(8285)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8285)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8285)/publications"},"_namespace":null},{"id":8286,"version":2,"created":1554914690000,"modified":1554914694000,"deprecated":false,"name":"Granzyme A","accession":"P12544","gene":"GZMA","description":"Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.517988717846873,"antibodyCount":275,"monoclonalCount":108,"pubmedCount":null,"jensenScore":315.226629,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.608771931163478,"pubTatorScore":2.2329347333877076,"self":"https://pharos.nih.gov/idg/api/v1/targets(8286)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(8286)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(8286)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8286)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8286)/publications"},"_namespace":null},{"id":8287,"version":2,"created":1554914694000,"modified":1554914699000,"deprecated":false,"name":"Glycogen phosphorylase, brain form","accession":"P11216","gene":"PYGB","description":"Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9882308497678667,"antibodyCount":415,"monoclonalCount":165,"pubmedCount":null,"jensenScore":97.542488,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.66746977343392,"pubTatorScore":2.242269807459566,"self":"https://pharos.nih.gov/idg/api/v1/targets(8287)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(8287)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(8287)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8287)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8287)/publications"},"_namespace":null},{"id":8288,"version":2,"created":1554914700000,"modified":1554914706000,"deprecated":false,"name":"Integrin alpha-M","accession":"P11215","gene":"ITGAM","description":"Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.6342687285983217,"antibodyCount":2165,"monoclonalCount":1731,"pubmedCount":null,"jensenScore":3939.492441,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.22441902260253,"pubTatorScore":3.3020515049759998,"self":"https://pharos.nih.gov/idg/api/v1/targets(8288)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":672,"href":"https://pharos.nih.gov/idg/api/v1/targets(8288)/properties"},"_links":{"count":1360,"href":"https://pharos.nih.gov/idg/api/v1/targets(8288)/links"},"_synonyms":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(8288)/synonyms"},"_publications":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(8288)/publications"},"_namespace":null},{"id":8289,"version":2,"created":1554914709000,"modified":1554914712000,"deprecated":false,"name":"Copine-3","accession":"O75131","gene":"CPNE3","description":"Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9548795044128118,"antibodyCount":119,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.437919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.56455466129342,"pubTatorScore":0.8481424201239217,"self":"https://pharos.nih.gov/idg/api/v1/targets(8289)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(8289)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(8289)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8289)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8289)/publications"},"_namespace":null},{"id":8290,"version":2,"created":1554914713000,"modified":1554914716000,"deprecated":false,"name":"Zinc finger BED domain-containing protein 4","accession":"O75132","gene":"ZBED4","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.6971566637535065,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.099206,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.474443578671153,"pubTatorScore":0.7201592206831905,"self":"https://pharos.nih.gov/idg/api/v1/targets(8290)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(8290)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(8290)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8290)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8290)/publications"},"_namespace":null},{"id":8291,"version":3,"created":1554914717000,"modified":1555038144000,"deprecated":false,"name":"Ras-related protein Rab-17","accession":"Q9H0T7","gene":"RAB17","description":"The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2505717409052226,"antibodyCount":158,"monoclonalCount":56,"pubmedCount":null,"jensenScore":20.750123,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":29.91344015555686,"pubTatorScore":0.8811624306183856,"self":"https://pharos.nih.gov/idg/api/v1/targets(8291)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(8291)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(8291)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8291)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8291)/publications"},"_namespace":null},{"id":8292,"version":2,"created":1554914720000,"modified":1554914723000,"deprecated":false,"name":"SLIT and NTRK-like protein 2","accession":"Q9H156","gene":"SLITRK2","description":"It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4996216339865657,"antibodyCount":130,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.803943,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.35447800108507,"pubTatorScore":0.3921103476344109,"self":"https://pharos.nih.gov/idg/api/v1/targets(8292)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(8292)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(8292)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8292)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8292)/publications"},"_namespace":null},{"id":8293,"version":4,"created":1554914724000,"modified":1555038145000,"deprecated":false,"name":"Epidermal growth factor receptor","accession":"P00533","gene":"EGFR","description":"(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-4.026502691267937,"antibodyCount":6418,"monoclonalCount":2395,"pubmedCount":null,"jensenScore":10013.118202,"patentCount":1239008,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":68.76548101837516,"pubTatorScore":4.318062344624057,"self":"https://pharos.nih.gov/idg/api/v1/targets(8293)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":5345,"href":"https://pharos.nih.gov/idg/api/v1/targets(8293)/properties"},"_links":{"count":7026,"href":"https://pharos.nih.gov/idg/api/v1/targets(8293)/links"},"_synonyms":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(8293)/synonyms"},"_publications":{"count":4620,"href":"https://pharos.nih.gov/idg/api/v1/targets(8293)/publications"},"_namespace":null},{"id":8294,"version":2,"created":1554915216000,"modified":1554915218000,"deprecated":false,"name":"Immunoglobulin heavy constant gamma 4","accession":"P01861","gene":"IGHG4","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.61107566975225,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8294)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/properties"},"_links":{"count":583,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8294)/publications"},"_namespace":null},{"id":8295,"version":3,"created":1554915218000,"modified":1555038168000,"deprecated":false,"name":"Regulator of G-protein signaling 7","accession":"P49802","gene":"RGS7","description":"Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6906588196875545,"antibodyCount":156,"monoclonalCount":3,"pubmedCount":null,"jensenScore":50.691385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.905833905516666,"pubTatorScore":1.4796301369322375,"self":"https://pharos.nih.gov/idg/api/v1/targets(8295)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(8295)/properties"},"_links":{"count":809,"href":"https://pharos.nih.gov/idg/api/v1/targets(8295)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8295)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8295)/publications"},"_namespace":null},{"id":8296,"version":2,"created":1554915223000,"modified":1554915223000,"deprecated":false,"name":"Immunoglobulin heavy constant gamma 3","accession":"P01860","gene":"IGHG3","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.832325862199723,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(8296)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8296)/properties"},"_links":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8296)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8296)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8296)/publications"},"_namespace":null},{"id":8297,"version":3,"created":1554915223000,"modified":1555038169000,"deprecated":false,"name":"Growth arrest and DNA damage-inducible protein GADD45 alpha","accession":"P24522","gene":"GADD45A","description":"In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6106141650543697,"antibodyCount":249,"monoclonalCount":27,"pubmedCount":null,"jensenScore":373.288584,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":50.51634279521124,"pubTatorScore":2.537651407410511,"self":"https://pharos.nih.gov/idg/api/v1/targets(8297)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(8297)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(8297)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8297)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(8297)/publications"},"_namespace":null},{"id":8298,"version":3,"created":1554915228000,"modified":1555038171000,"deprecated":false,"name":"Protein cordon-bleu","accession":"O75128","gene":"COBL","description":"Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.411666991914805,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":26.932597,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.797849004677786,"pubTatorScore":1.1950418903257476,"self":"https://pharos.nih.gov/idg/api/v1/targets(8298)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(8298)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(8298)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8298)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8298)/publications"},"_namespace":null},{"id":8299,"version":3,"created":1554915234000,"modified":1555038172000,"deprecated":false,"name":"Astrotactin-2","accession":"O75129","gene":"ASTN2","description":"Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0085906729768876,"antibodyCount":98,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.486785,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.3582617944815,"pubTatorScore":0.9524165697131599,"self":"https://pharos.nih.gov/idg/api/v1/targets(8299)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8299)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(8299)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8299)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8299)/publications"},"_namespace":null},{"id":8300,"version":2,"created":1554915238000,"modified":1554915241000,"deprecated":false,"name":"Pentatricopeptide repeat-containing protein 1, mitochondrial","accession":"O75127","gene":"PTCD1","description":"Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.634589221559436,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.324145,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.457918362720285,"pubTatorScore":0.5043952791627401,"self":"https://pharos.nih.gov/idg/api/v1/targets(8300)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(8300)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(8300)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8300)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8300)/publications"},"_namespace":null},{"id":8301,"version":2,"created":1554915241000,"modified":1554915244000,"deprecated":false,"name":"Deoxynucleotidyltransferase terminal-interacting protein 1","accession":"Q9H147","gene":"DNTTIP1","description":"Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5492076858122471,"antibodyCount":151,"monoclonalCount":54,"pubmedCount":null,"jensenScore":3.924008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.793735513026014,"pubTatorScore":0.6232492903979004,"self":"https://pharos.nih.gov/idg/api/v1/targets(8301)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(8301)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(8301)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8301)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8301)/publications"},"_namespace":null},{"id":8302,"version":3,"created":1554915244000,"modified":1555038173000,"deprecated":false,"name":"CLIP-associating protein 2","accession":"O75122","gene":"CLASP2","description":"Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3175368584719411,"antibodyCount":260,"monoclonalCount":14,"pubmedCount":null,"jensenScore":22.413674,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.85152077572264,"pubTatorScore":1.2600713879850747,"self":"https://pharos.nih.gov/idg/api/v1/targets(8302)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(8302)/properties"},"_links":{"count":1131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8302)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8302)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8302)/publications"},"_namespace":null},{"id":8303,"version":2,"created":1554915249000,"modified":1554915252000,"deprecated":false,"name":"Zinc finger protein 623","accession":"O75123","gene":"ZNF623","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":47,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.232545661365506,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8303)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(8303)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(8303)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8303)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8303)/publications"},"_namespace":null},{"id":8304,"version":2,"created":1554915252000,"modified":1554915255000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX47","accession":"Q9H0S4","gene":"DDX47","description":"Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7766288619995179,"antibodyCount":152,"monoclonalCount":15,"pubmedCount":null,"jensenScore":6.24883,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.282734325596536,"pubTatorScore":0.7750695912904358,"self":"https://pharos.nih.gov/idg/api/v1/targets(8304)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(8304)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(8304)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8304)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8304)/publications"},"_namespace":null},{"id":8305,"version":2,"created":1554915256000,"modified":1554915259000,"deprecated":false,"name":"Microfibrillar-associated protein 3-like","accession":"O75121","gene":"MFAP3L","description":"May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.07685507711603999,"antibodyCount":66,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.595833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.387332433705684,"pubTatorScore":0.32969212350798077,"self":"https://pharos.nih.gov/idg/api/v1/targets(8305)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(8305)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(8305)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8305)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8305)/publications"},"_namespace":null},{"id":8306,"version":2,"created":1554915260000,"modified":1554915263000,"deprecated":false,"name":"Adenylate kinase isoenzyme 1","accession":"P00568","gene":"AK1","description":"Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.3771769408986554,"antibodyCount":422,"monoclonalCount":122,"pubmedCount":null,"jensenScore":230.093689,"patentCount":8293,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.84566978862425,"pubTatorScore":2.2716478842549286,"self":"https://pharos.nih.gov/idg/api/v1/targets(8306)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(8306)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(8306)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8306)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8306)/publications"},"_namespace":null},{"id":8307,"version":2,"created":1554915264000,"modified":1554915264000,"deprecated":false,"name":"Olfactory receptor 7E24","accession":"Q6IFN5","gene":"OR7E24","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.4065401804339551,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.182857,"patentCount":5650,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.697771079173425,"pubTatorScore":1.1712387172235612,"self":"https://pharos.nih.gov/idg/api/v1/targets(8307)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8307)/properties"},"_links":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8307)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8307)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8307)/publications"},"_namespace":null},{"id":8308,"version":2,"created":1554915264000,"modified":1554915265000,"deprecated":false,"name":"Putative HLA class I histocompatibility antigen, alpha chain H","accession":"P01893","gene":"HLA-H","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.77132904540884,"pubTatorScore":0.43933269383026263,"self":"https://pharos.nih.gov/idg/api/v1/targets(8308)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8308)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8308)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8308)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8308)/publications"},"_namespace":null},{"id":8309,"version":3,"created":1554915265000,"modified":1555038175000,"deprecated":false,"name":"HLA class I histocompatibility antigen, A-2 alpha chain","accession":"P01892","gene":"HLA-A","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.416669710281058,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4123.756732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":3.457240582152559,"self":"https://pharos.nih.gov/idg/api/v1/targets(8309)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1457,"href":"https://pharos.nih.gov/idg/api/v1/targets(8309)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(8309)/links"},"_synonyms":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(8309)/synonyms"},"_publications":{"count":1230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8309)/publications"},"_namespace":null},{"id":8310,"version":2,"created":1554915274000,"modified":1554915279000,"deprecated":false,"name":"HLA class I histocompatibility antigen, A-68 alpha chain","accession":"P01891","gene":"HLA-A","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.416669710281058,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4123.756732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.457240582152559,"self":"https://pharos.nih.gov/idg/api/v1/targets(8310)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1436,"href":"https://pharos.nih.gov/idg/api/v1/targets(8310)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(8310)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8310)/synonyms"},"_publications":{"count":1227,"href":"https://pharos.nih.gov/idg/api/v1/targets(8310)/publications"},"_namespace":null},{"id":8311,"version":3,"created":1554915283000,"modified":1555038179000,"deprecated":false,"name":"GTP-binding nuclear protein Ran","accession":"P62826","gene":"RAN","description":"The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.5476936432025896,"antibodyCount":452,"monoclonalCount":21,"pubmedCount":null,"jensenScore":315.966432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":52.47174473449089,"pubTatorScore":2.9833239332349675,"self":"https://pharos.nih.gov/idg/api/v1/targets(8311)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":583,"href":"https://pharos.nih.gov/idg/api/v1/targets(8311)/properties"},"_links":{"count":1194,"href":"https://pharos.nih.gov/idg/api/v1/targets(8311)/links"},"_synonyms":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(8311)/synonyms"},"_publications":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8311)/publications"},"_namespace":null},{"id":8312,"version":2,"created":1554915288000,"modified":1554915291000,"deprecated":false,"name":"60S ribosomal protein L23","accession":"P62829","gene":"RPL23","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.578120449416749,"antibodyCount":118,"monoclonalCount":5,"pubmedCount":null,"jensenScore":38.069311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.33407125297739,"pubTatorScore":1.0535966357033186,"self":"https://pharos.nih.gov/idg/api/v1/targets(8312)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":453,"href":"https://pharos.nih.gov/idg/api/v1/targets(8312)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(8312)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8312)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8312)/publications"},"_namespace":null},{"id":8313,"version":4,"created":1554915292000,"modified":1555038181000,"deprecated":false,"name":"Rho-associated protein kinase 2","accession":"O75116","gene":"ROCK2","description":"Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.48707024870259,"antibodyCount":490,"monoclonalCount":66,"pubmedCount":null,"jensenScore":283.030314,"patentCount":15745,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":56.68377260696311,"pubTatorScore":2.253184217981177,"self":"https://pharos.nih.gov/idg/api/v1/targets(8313)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":640,"href":"https://pharos.nih.gov/idg/api/v1/targets(8313)/properties"},"_links":{"count":1829,"href":"https://pharos.nih.gov/idg/api/v1/targets(8313)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8313)/synonyms"},"_publications":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(8313)/publications"},"_namespace":null},{"id":8314,"version":2,"created":1554915484000,"modified":1554915487000,"deprecated":false,"name":"NEDD4-binding protein 1","accession":"O75113","gene":"N4BP1","description":"Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7027397516010898,"antibodyCount":91,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.54655,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.3243006917107,"pubTatorScore":0.5575379984279457,"self":"https://pharos.nih.gov/idg/api/v1/targets(8314)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(8314)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(8314)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8314)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8314)/publications"},"_namespace":null},{"id":8315,"version":3,"created":1554915488000,"modified":1555038184000,"deprecated":false,"name":"Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial","accession":"Q9H0R6","gene":"QRSL1","description":"Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9074221557323887,"antibodyCount":102,"monoclonalCount":3,"pubmedCount":null,"jensenScore":73.119739,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.61929961720675,"pubTatorScore":2.5581034468758874,"self":"https://pharos.nih.gov/idg/api/v1/targets(8315)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(8315)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(8315)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8315)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8315)/publications"},"_namespace":null},{"id":8316,"version":3,"created":1554915492000,"modified":1555038185000,"deprecated":false,"name":"Transgelin-2","accession":"P37802","gene":"TAGLN2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5716638242951042,"antibodyCount":139,"monoclonalCount":4,"pubmedCount":null,"jensenScore":36.733521,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.46467235164327,"pubTatorScore":1.4786992020585188,"self":"https://pharos.nih.gov/idg/api/v1/targets(8316)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(8316)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(8316)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8316)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8316)/publications"},"_namespace":null},{"id":8317,"version":2,"created":1554915496000,"modified":1554915496000,"deprecated":false,"name":"Putative myc-like protein MYCLP1","accession":"P12525","gene":"MYCLP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.937952838252568,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8317)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8317)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8317)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8317)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8317)/publications"},"_namespace":null},{"id":8318,"version":2,"created":1554915496000,"modified":1554915501000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor-associated protein-like 1","accession":"Q9H0R8","gene":"GABARAPL1","description":"Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3969184475837584,"antibodyCount":211,"monoclonalCount":1,"pubmedCount":null,"jensenScore":232.679122,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.52962448795092,"pubTatorScore":2.0075065581330835,"self":"https://pharos.nih.gov/idg/api/v1/targets(8318)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(8318)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(8318)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8318)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8318)/publications"},"_namespace":null},{"id":8319,"version":3,"created":1554915502000,"modified":1555038187000,"deprecated":false,"name":"Protein L-Myc","accession":"P12524","gene":"MYCL","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.689593480398437,"antibodyCount":87,"monoclonalCount":6,"pubmedCount":null,"jensenScore":450.667928,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":39,"knowledgeAvailability":34.608011020241406,"pubTatorScore":2.2620249232517424,"self":"https://pharos.nih.gov/idg/api/v1/targets(8319)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(8319)/properties"},"_links":{"count":808,"href":"https://pharos.nih.gov/idg/api/v1/targets(8319)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8319)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8319)/publications"},"_namespace":null},{"id":8320,"version":3,"created":1554915506000,"modified":1555038189000,"deprecated":false,"name":"LIM domain-binding protein 3","accession":"O75112","gene":"LDB3","description":"May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.879728864419547,"antibodyCount":182,"monoclonalCount":34,"pubmedCount":null,"jensenScore":736.444589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.64205816298343,"pubTatorScore":2.428066032314772,"self":"https://pharos.nih.gov/idg/api/v1/targets(8320)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(8320)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(8320)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(8320)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8320)/publications"},"_namespace":null},{"id":8321,"version":2,"created":1554915511000,"modified":1554915514000,"deprecated":false,"name":"Transmembrane protein 222","accession":"Q9H0R3","gene":"TMEM222","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.514150950239216,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8321)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(8321)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(8321)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8321)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8321)/publications"},"_namespace":null},{"id":8322,"version":2,"created":1554915514000,"modified":1554915518000,"deprecated":false,"name":"Probable phospholipid-transporting ATPase IIA","accession":"O75110","gene":"ATP9A","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.33571255152700724,"antibodyCount":38,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.277958,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.516382109414785,"pubTatorScore":0.020531983186387902,"self":"https://pharos.nih.gov/idg/api/v1/targets(8322)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(8322)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(8322)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8322)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8322)/publications"},"_namespace":null},{"id":8323,"version":2,"created":1554915519000,"modified":1554915522000,"deprecated":false,"name":"Guanylate-binding protein 3","accession":"Q9H0R5","gene":"GBP3","description":"Exhibits antiviral activity against influenza virus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9384085086103546,"antibodyCount":119,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.007832,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.60493909420928,"pubTatorScore":0.8985007929844578,"self":"https://pharos.nih.gov/idg/api/v1/targets(8323)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(8323)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(8323)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8323)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8323)/publications"},"_namespace":null},{"id":8324,"version":3,"created":1554915523000,"modified":1555038190000,"deprecated":false,"name":"Haloacid dehalogenase-like hydrolase domain-containing protein 2","accession":"Q9H0R4","gene":"HDHD2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4636441828658802,"antibodyCount":118,"monoclonalCount":63,"pubmedCount":null,"jensenScore":2.901111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.181751516054316,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(8324)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8324)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(8324)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8324)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8324)/publications"},"_namespace":null},{"id":8325,"version":3,"created":1554915526000,"modified":1555038191000,"deprecated":false,"name":"AP-5 complex subunit mu-1","accession":"Q9H0R1","gene":"AP5M1","description":"As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.7449632842868936,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":54.431162,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.900751105464618,"pubTatorScore":1.0619547938656566,"self":"https://pharos.nih.gov/idg/api/v1/targets(8325)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(8325)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(8325)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8325)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8325)/publications"},"_namespace":null},{"id":8326,"version":2,"created":1554915530000,"modified":1554915538000,"deprecated":false,"name":"Phosphoglycerate kinase 1","accession":"P00558","gene":"PGK1","description":"In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.79738092386167,"antibodyCount":340,"monoclonalCount":19,"pubmedCount":null,"jensenScore":602.538129,"patentCount":38416,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.86663579503836,"pubTatorScore":2.3860702899993966,"self":"https://pharos.nih.gov/idg/api/v1/targets(8326)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(8326)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(8326)/links"},"_synonyms":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(8326)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8326)/publications"},"_namespace":null},{"id":8327,"version":3,"created":1554915539000,"modified":1555038195000,"deprecated":false,"name":"HLA class I histocompatibility antigen, B-7 alpha chain","accession":"P01889","gene":"HLA-B","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8875247029897861,"antibodyCount":362,"monoclonalCount":184,"pubmedCount":null,"jensenScore":1613.472112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":0.0,"pubTatorScore":3.7801564385417628,"self":"https://pharos.nih.gov/idg/api/v1/targets(8327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2182,"href":"https://pharos.nih.gov/idg/api/v1/targets(8327)/properties"},"_links":{"count":2345,"href":"https://pharos.nih.gov/idg/api/v1/targets(8327)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8327)/synonyms"},"_publications":{"count":1772,"href":"https://pharos.nih.gov/idg/api/v1/targets(8327)/publications"},"_namespace":null},{"id":8328,"version":2,"created":1554915556000,"modified":1554915556000,"deprecated":false,"name":"T-cell receptor beta-2 chain C region","accession":"A0A5B9","gene":"TRBC2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.251046119632166,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8328)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8328)/links"},"_synonyms":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8328)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8328)/publications"},"_namespace":null},{"id":8329,"version":3,"created":1554915556000,"modified":1555038201000,"deprecated":false,"name":"Ras-related protein Rab-1A","accession":"P62820","gene":"RAB1A","description":"The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.3915199655649753,"antibodyCount":112,"monoclonalCount":10,"pubmedCount":null,"jensenScore":254.019703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":48.36784728846232,"pubTatorScore":2.1829721716561443,"self":"https://pharos.nih.gov/idg/api/v1/targets(8329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(8329)/properties"},"_links":{"count":1212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8329)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(8329)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8329)/publications"},"_namespace":null},{"id":8330,"version":3,"created":1554915562000,"modified":1555038204000,"deprecated":false,"name":"Carbonic anhydrase-related protein","accession":"P35219","gene":"CA8","description":"Does not have a carbonic anhydrase catalytic activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4309539835540996,"antibodyCount":152,"monoclonalCount":21,"pubmedCount":null,"jensenScore":258.534595,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":34.95202086077645,"pubTatorScore":1.835433862469298,"self":"https://pharos.nih.gov/idg/api/v1/targets(8330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(8330)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(8330)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8330)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8330)/publications"},"_namespace":null},{"id":8331,"version":2,"created":1554915565000,"modified":1554915569000,"deprecated":false,"name":"Kallikrein-7","accession":"P49862","gene":"KLK7","description":"May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.133889369037907,"antibodyCount":297,"monoclonalCount":24,"pubmedCount":null,"jensenScore":143.81071,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.61638175664152,"pubTatorScore":2.010351250405102,"self":"https://pharos.nih.gov/idg/api/v1/targets(8331)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(8331)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(8331)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8331)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8331)/publications"},"_namespace":null},{"id":8332,"version":3,"created":1554915570000,"modified":1555038205000,"deprecated":false,"name":"Retina-specific copper amine oxidase","accession":"O75106","gene":"AOC2","description":"Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.260464837179107,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":183.264648,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.268557896939654,"pubTatorScore":2.159391713643141,"self":"https://pharos.nih.gov/idg/api/v1/targets(8332)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(8332)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(8332)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8332)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8332)/publications"},"_namespace":null},{"id":8333,"version":3,"created":1554915575000,"modified":1554915733000,"deprecated":false,"name":"Neuronal acetylcholine receptor subunit alpha-7","accession":"P36544","gene":"CHRFAM7A","description":"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.8117325964972963,"antibodyCount":226,"monoclonalCount":24,"pubmedCount":null,"jensenScore":87.73709,"patentCount":6150,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.0606978403536116,"self":"https://pharos.nih.gov/idg/api/v1/targets(8333)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":427,"href":"https://pharos.nih.gov/idg/api/v1/targets(8333)/properties"},"_links":{"count":1351,"href":"https://pharos.nih.gov/idg/api/v1/targets(8333)/links"},"_synonyms":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(8333)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8333)/publications"},"_namespace":null},{"id":8334,"version":2,"created":1554915735000,"modified":1554915739000,"deprecated":false,"name":"V-type proton ATPase subunit E 1","accession":"P36543","gene":"ATP6V1E1","description":"Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.040908165633932,"antibodyCount":137,"monoclonalCount":21,"pubmedCount":null,"jensenScore":10.703789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.251564933986316,"pubTatorScore":2.238614481082607,"self":"https://pharos.nih.gov/idg/api/v1/targets(8334)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(8334)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(8334)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8334)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8334)/publications"},"_namespace":null},{"id":8335,"version":2,"created":1554915739000,"modified":1554915743000,"deprecated":false,"name":"Gap junction alpha-4 protein","accession":"P35212","gene":"GJA4","description":"One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2704262262380284,"antibodyCount":231,"monoclonalCount":2,"pubmedCount":null,"jensenScore":180.622507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.352767646660254,"pubTatorScore":2.060650450575457,"self":"https://pharos.nih.gov/idg/api/v1/targets(8335)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(8335)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(8335)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8335)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8335)/publications"},"_namespace":null},{"id":8336,"version":3,"created":1554915744000,"modified":1555038206000,"deprecated":false,"name":"ATP synthase subunit gamma, mitochondrial","accession":"P36542","gene":"ATP5F1C","description":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6436106928761582,"antibodyCount":139,"monoclonalCount":18,"pubmedCount":null,"jensenScore":3.840252,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":0.1429141822517233,"self":"https://pharos.nih.gov/idg/api/v1/targets(8336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(8336)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(8336)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8336)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(8336)/publications"},"_namespace":null},{"id":8337,"version":4,"created":1554915747000,"modified":1555038207000,"deprecated":false,"name":"Carbonic anhydrase 5A, mitochondrial","accession":"P35218","gene":"CA5A","description":"Reversible hydration of carbon dioxide. Low activity.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.5097338286552624,"antibodyCount":96,"monoclonalCount":5,"pubmedCount":null,"jensenScore":304.128665,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":23.88856608206768,"pubTatorScore":2.0061160096318003,"self":"https://pharos.nih.gov/idg/api/v1/targets(8337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(8337)/properties"},"_links":{"count":649,"href":"https://pharos.nih.gov/idg/api/v1/targets(8337)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8337)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8337)/publications"},"_namespace":null},{"id":8338,"version":3,"created":1554915772000,"modified":1555038208000,"deprecated":false,"name":"Arylamine N-acetyltransferase 2","accession":"P11245","gene":"NAT2","description":"Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.737919286404115,"antibodyCount":266,"monoclonalCount":39,"pubmedCount":null,"jensenScore":569.039121,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":26.029716684986408,"pubTatorScore":3.0555689715653256,"self":"https://pharos.nih.gov/idg/api/v1/targets(8338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(8338)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(8338)/links"},"_synonyms":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(8338)/synonyms"},"_publications":{"count":658,"href":"https://pharos.nih.gov/idg/api/v1/targets(8338)/publications"},"_namespace":null},{"id":8339,"version":3,"created":1554915780000,"modified":1555038212000,"deprecated":false,"name":"Catenin alpha-1","accession":"P35221","gene":"CTNNA1","description":"Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9447922085649862,"antibodyCount":488,"monoclonalCount":89,"pubmedCount":null,"jensenScore":78.10362,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":55.03066820574774,"pubTatorScore":2.4076209074447776,"self":"https://pharos.nih.gov/idg/api/v1/targets(8339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(8339)/properties"},"_links":{"count":1239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8339)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(8339)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(8339)/publications"},"_namespace":null},{"id":8340,"version":3,"created":1554915786000,"modified":1555038216000,"deprecated":false,"name":"Integrin alpha-6","accession":"P23229","gene":"ITGA6","description":"Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3012689233401638,"antibodyCount":944,"monoclonalCount":653,"pubmedCount":null,"jensenScore":180.440682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":54.94300994411781,"pubTatorScore":2.3231512392987392,"self":"https://pharos.nih.gov/idg/api/v1/targets(8340)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":724,"href":"https://pharos.nih.gov/idg/api/v1/targets(8340)/properties"},"_links":{"count":1315,"href":"https://pharos.nih.gov/idg/api/v1/targets(8340)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(8340)/synonyms"},"_publications":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(8340)/publications"},"_namespace":null},{"id":8341,"version":2,"created":1554915793000,"modified":1554915797000,"deprecated":false,"name":"Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial","accession":"P36551","gene":"CPOX","description":"Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0550447962452068,"antibodyCount":87,"monoclonalCount":7,"pubmedCount":null,"jensenScore":112.448671,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.41985766095225,"pubTatorScore":2.074912175940798,"self":"https://pharos.nih.gov/idg/api/v1/targets(8341)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(8341)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(8341)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8341)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8341)/publications"},"_namespace":null},{"id":8342,"version":4,"created":1554915797000,"modified":1555038219000,"deprecated":false,"name":"Thromboxane-A synthase","accession":"P24557","gene":"TBXAS1","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.1651217160446774,"antibodyCount":264,"monoclonalCount":71,"pubmedCount":null,"jensenScore":1395.908033,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":47.587512701743975,"pubTatorScore":1.9596284573870513,"self":"https://pharos.nih.gov/idg/api/v1/targets(8342)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(8342)/properties"},"_links":{"count":1739,"href":"https://pharos.nih.gov/idg/api/v1/targets(8342)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(8342)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8342)/publications"},"_namespace":null},{"id":8343,"version":3,"created":1554916012000,"modified":1555038222000,"deprecated":false,"name":"Ubiquitin-like-conjugating enzyme ATG10","accession":"Q9H0Y0","gene":"ATG10","description":"E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.333009980820555,"antibodyCount":231,"monoclonalCount":11,"pubmedCount":null,"jensenScore":17.059691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.861707868786304,"pubTatorScore":1.2711414800219274,"self":"https://pharos.nih.gov/idg/api/v1/targets(8343)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(8343)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(8343)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8343)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8343)/publications"},"_namespace":null},{"id":8344,"version":2,"created":1554916017000,"modified":1554916017000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC01553","accession":"A4QN01","gene":"LINC01553","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.4047354473333735,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8344)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8344)/properties"},"_links":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8344)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8344)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8344)/publications"},"_namespace":null},{"id":8345,"version":2,"created":1554916017000,"modified":1554916019000,"deprecated":false,"name":"Nuclear apoptosis-inducing factor 1","accession":"Q69YI7","gene":"NAIF1","description":"Induces apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6851016487584309,"antibodyCount":47,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.146655,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.56704219982202,"pubTatorScore":0.8206392126218388,"self":"https://pharos.nih.gov/idg/api/v1/targets(8345)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(8345)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(8345)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8345)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8345)/publications"},"_namespace":null},{"id":8346,"version":2,"created":1554916019000,"modified":1554916022000,"deprecated":false,"name":"SH3 and PX domain-containing protein 2B","accession":"A1X283","gene":"SH3PXD2B","description":"Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7287152045762781,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":53.340898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.77098776590116,"pubTatorScore":1.1903316701512918,"self":"https://pharos.nih.gov/idg/api/v1/targets(8346)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8346)/publications"},"_namespace":null},{"id":8347,"version":3,"created":1554916023000,"modified":1555038223000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 5","accession":"Q9H0X9","gene":"OSBPL5","description":"Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0139709619420811,"antibodyCount":63,"monoclonalCount":3,"pubmedCount":null,"jensenScore":10.187636,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":32.26694662468067,"pubTatorScore":1.0213590130055017,"self":"https://pharos.nih.gov/idg/api/v1/targets(8347)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(8347)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(8347)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8347)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8347)/publications"},"_namespace":null},{"id":8348,"version":2,"created":1554916027000,"modified":1554916028000,"deprecated":false,"name":"UDP-glucuronosyltransferase 2B10","accession":"P36537","gene":"UGT2B10","description":"UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2805328100552609,"antibodyCount":91,"monoclonalCount":28,"pubmedCount":null,"jensenScore":19.509117,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.950945890739394,"pubTatorScore":1.3767914601471993,"self":"https://pharos.nih.gov/idg/api/v1/targets(8348)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(8348)/properties"},"_links":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(8348)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8348)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8348)/publications"},"_namespace":null},{"id":8349,"version":2,"created":1554916029000,"modified":1554916029000,"deprecated":false,"name":"Mucin-3B","accession":"Q9H195","gene":"MUC3B","description":"Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.33279398335874283,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.745054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.297940553738394,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(8349)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8349)/properties"},"_links":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(8349)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8349)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8349)/publications"},"_namespace":null},{"id":8350,"version":2,"created":1554916029000,"modified":1554916031000,"deprecated":false,"name":"Protein FAM234A","accession":"Q9H0X4","gene":"FAM234A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.37891676903202964,"antibodyCount":83,"monoclonalCount":36,"pubmedCount":null,"jensenScore":2.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8350)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(8350)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(8350)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8350)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8350)/publications"},"_namespace":null},{"id":8351,"version":2,"created":1554916032000,"modified":1554916034000,"deprecated":false,"name":"RING finger protein 208","accession":"Q9H0X6","gene":"RNF208","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.9030899869919435,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.05713394102737,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8351)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8351)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(8351)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8351)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8351)/publications"},"_namespace":null},{"id":8352,"version":2,"created":1554916035000,"modified":1554916037000,"deprecated":false,"name":"Syntenin-2","accession":"Q9H190","gene":"SDCBP2","description":"Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8348847346156494,"antibodyCount":182,"monoclonalCount":15,"pubmedCount":null,"jensenScore":7.253409,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.252692006175764,"pubTatorScore":0.9454217063720167,"self":"https://pharos.nih.gov/idg/api/v1/targets(8352)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(8352)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(8352)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8352)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8352)/publications"},"_namespace":null},{"id":8353,"version":2,"created":1554916038000,"modified":1554916040000,"deprecated":false,"name":"Serine/threonine-protein kinase 19","accession":"P49842","gene":"STK19","description":"Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8600954231489946,"antibodyCount":142,"monoclonalCount":7,"pubmedCount":null,"jensenScore":71.62597,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.66448170605737,"pubTatorScore":1.938821664998934,"self":"https://pharos.nih.gov/idg/api/v1/targets(8353)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(8353)/properties"},"_links":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(8353)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8353)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8353)/publications"},"_namespace":null},{"id":8354,"version":4,"created":1554916041000,"modified":1555038225000,"deprecated":false,"name":"Glycogen synthase kinase-3 beta","accession":"P49841","gene":"GSK3B","description":"Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.003904434136001,"antibodyCount":955,"monoclonalCount":256,"pubmedCount":null,"jensenScore":610.77754,"patentCount":67254,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":68.32641393015203,"pubTatorScore":3.2732725933181466,"self":"https://pharos.nih.gov/idg/api/v1/targets(8354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1665,"href":"https://pharos.nih.gov/idg/api/v1/targets(8354)/properties"},"_links":{"count":2475,"href":"https://pharos.nih.gov/idg/api/v1/targets(8354)/links"},"_synonyms":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(8354)/synonyms"},"_publications":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(8354)/publications"},"_namespace":null},{"id":8355,"version":2,"created":1554916229000,"modified":1554916231000,"deprecated":false,"name":"Zinc finger protein 831","accession":"Q5JPB2","gene":"ZNF831","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.68521253579583,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(8355)/properties"},"_links":{"count":745,"href":"https://pharos.nih.gov/idg/api/v1/targets(8355)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8355)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8355)/publications"},"_namespace":null},{"id":8356,"version":2,"created":1554916232000,"modified":1554916235000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 6","accession":"P49848","gene":"TAF6","description":"TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.10649833784834,"antibodyCount":159,"monoclonalCount":13,"pubmedCount":null,"jensenScore":12.836497,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.788844070907764,"pubTatorScore":1.306185316640621,"self":"https://pharos.nih.gov/idg/api/v1/targets(8356)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(8356)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(8356)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8356)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8356)/publications"},"_namespace":null},{"id":8357,"version":2,"created":1554916236000,"modified":1554916236000,"deprecated":false,"name":"Putative uncharacterized protein LOC401522","accession":"Q5VSD8","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8357)/properties"},"_links":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8357)/links"},"_synonyms":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8357)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8357)/publications"},"_namespace":null},{"id":8358,"version":2,"created":1554916236000,"modified":1554916238000,"deprecated":false,"name":"Transmembrane protein 42","accession":"Q69YG0","gene":"TMEM42","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":22,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.29685040338302,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(8358)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(8358)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8358)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8358)/publications"},"_namespace":null},{"id":8359,"version":4,"created":1554916238000,"modified":1555038232000,"deprecated":false,"name":"Glycogen synthase kinase-3 alpha","accession":"P49840","gene":"GSK3A","description":"Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-1.828797062311238,"antibodyCount":840,"monoclonalCount":261,"pubmedCount":null,"jensenScore":53.097389,"patentCount":6631,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":49.996646882766186,"pubTatorScore":2.1580799429132416,"self":"https://pharos.nih.gov/idg/api/v1/targets(8359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":631,"href":"https://pharos.nih.gov/idg/api/v1/targets(8359)/properties"},"_links":{"count":1268,"href":"https://pharos.nih.gov/idg/api/v1/targets(8359)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8359)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8359)/publications"},"_namespace":null},{"id":8360,"version":3,"created":1554916257000,"modified":1554916470000,"deprecated":false,"name":"Muscarinic acetylcholine receptor M1","accession":"P11229","gene":"CHRM1","description":"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.161592981610592,"antibodyCount":222,"monoclonalCount":2,"pubmedCount":null,"jensenScore":140.767422,"patentCount":30541,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.99822950509408,"pubTatorScore":2.508745389243954,"self":"https://pharos.nih.gov/idg/api/v1/targets(8360)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(8360)/properties"},"_links":{"count":1562,"href":"https://pharos.nih.gov/idg/api/v1/targets(8360)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(8360)/synonyms"},"_publications":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8360)/publications"},"_namespace":null},{"id":8361,"version":3,"created":1554916472000,"modified":1555038234000,"deprecated":false,"name":"Mannose-binding protein C","accession":"P11226","gene":"MBL2","description":"Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7887966675628824,"antibodyCount":359,"monoclonalCount":137,"pubmedCount":null,"jensenScore":522.826271,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.511633633518027,"pubTatorScore":3.2221251328254414,"self":"https://pharos.nih.gov/idg/api/v1/targets(8361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(8361)/properties"},"_links":{"count":785,"href":"https://pharos.nih.gov/idg/api/v1/targets(8361)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(8361)/synonyms"},"_publications":{"count":718,"href":"https://pharos.nih.gov/idg/api/v1/targets(8361)/publications"},"_namespace":null},{"id":8362,"version":3,"created":1554916478000,"modified":1555038236000,"deprecated":false,"name":"Protein SMG9","accession":"Q9H0W8","gene":"SMG9","description":"Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.8383843707633014,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":66.815325,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.58175069552636,"pubTatorScore":0.6163003954188228,"self":"https://pharos.nih.gov/idg/api/v1/targets(8362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(8362)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(8362)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8362)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8362)/publications"},"_namespace":null},{"id":8363,"version":3,"created":1554916481000,"modified":1555038237000,"deprecated":false,"name":"THAP domain-containing protein 2","accession":"Q9H0W7","gene":"THAP2","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.5696664612938194,"antibodyCount":37,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.331574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":28.65009728162191,"pubTatorScore":0.22184883647524403,"self":"https://pharos.nih.gov/idg/api/v1/targets(8363)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(8363)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(8363)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8363)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8363)/publications"},"_namespace":null},{"id":8364,"version":3,"created":1554916484000,"modified":1555038238000,"deprecated":false,"name":"Ester hydrolase C11orf54","accession":"Q9H0W9","gene":"C11orf54","description":"Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.36000785214896325,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.215909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(8364)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(8364)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(8364)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8364)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8364)/publications"},"_namespace":null},{"id":8365,"version":2,"created":1554916488000,"modified":1554916491000,"deprecated":false,"name":"CD151 antigen","accession":"P48509","gene":"CD151","description":"(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4001311136561427,"antibodyCount":420,"monoclonalCount":237,"pubmedCount":null,"jensenScore":244.534373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.97013229573482,"pubTatorScore":2.3111865308636346,"self":"https://pharos.nih.gov/idg/api/v1/targets(8365)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":505,"href":"https://pharos.nih.gov/idg/api/v1/targets(8365)/properties"},"_links":{"count":1289,"href":"https://pharos.nih.gov/idg/api/v1/targets(8365)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8365)/synonyms"},"_publications":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8365)/publications"},"_namespace":null},{"id":8366,"version":3,"created":1554916493000,"modified":1555038240000,"deprecated":false,"name":"Acetylcholine receptor subunit beta","accession":"P11230","gene":"CHRNB1","description":"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.2622187543962644,"antibodyCount":180,"monoclonalCount":39,"pubmedCount":null,"jensenScore":17.862531,"patentCount":1362,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":37.389149423067195,"pubTatorScore":1.3952943397303939,"self":"https://pharos.nih.gov/idg/api/v1/targets(8366)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(8366)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(8366)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8366)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8366)/publications"},"_namespace":null},{"id":8367,"version":3,"created":1554916507000,"modified":1555038241000,"deprecated":false,"name":"Glutamate--cysteine ligase regulatory subunit","accession":"P48507","gene":"GCLM","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.238553307710283,"antibodyCount":277,"monoclonalCount":72,"pubmedCount":null,"jensenScore":156.267848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":47.27616751743949,"pubTatorScore":1.8994761793863457,"self":"https://pharos.nih.gov/idg/api/v1/targets(8367)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(8367)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(8367)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8367)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8367)/publications"},"_namespace":null},{"id":8368,"version":3,"created":1554916511000,"modified":1555038243000,"deprecated":false,"name":"Coiled-coil domain-containing protein 8","accession":"Q9H0W5","gene":"CCDC8","description":"Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0654374193063372,"antibodyCount":98,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.223093,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.693384910128767,"pubTatorScore":1.1105763445967358,"self":"https://pharos.nih.gov/idg/api/v1/targets(8368)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(8368)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(8368)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8368)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8368)/publications"},"_namespace":null},{"id":8369,"version":3,"created":1554916515000,"modified":1555038244000,"deprecated":false,"name":"ATP synthase F(0) complex subunit B1, mitochondrial","accession":"P24539","gene":"ATP5PB","description":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7938233802514453,"antibodyCount":113,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.362394,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":0.0,"pubTatorScore":0.16385670337134814,"self":"https://pharos.nih.gov/idg/api/v1/targets(8369)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(8369)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(8369)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8369)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8369)/publications"},"_namespace":null},{"id":8370,"version":3,"created":1554916519000,"modified":1555038245000,"deprecated":false,"name":"Elongation factor 1-beta","accession":"P24534","gene":"EEF1B2","description":"EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7437863376711042,"antibodyCount":110,"monoclonalCount":18,"pubmedCount":null,"jensenScore":54.316334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.728130839756076,"pubTatorScore":1.4549053065459412,"self":"https://pharos.nih.gov/idg/api/v1/targets(8370)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(8370)/properties"},"_links":{"count":1171,"href":"https://pharos.nih.gov/idg/api/v1/targets(8370)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8370)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8370)/publications"},"_namespace":null},{"id":8371,"version":4,"created":1554916523000,"modified":1555038248000,"deprecated":false,"name":"Endothelin receptor type B","accession":"P24530","gene":"EDNRB","description":"Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-3.2777116764582583,"antibodyCount":324,"monoclonalCount":19,"pubmedCount":null,"jensenScore":1756.676715,"patentCount":27777,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":51.149250090635384,"pubTatorScore":2.77826049138242,"self":"https://pharos.nih.gov/idg/api/v1/targets(8371)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":596,"href":"https://pharos.nih.gov/idg/api/v1/targets(8371)/properties"},"_links":{"count":1380,"href":"https://pharos.nih.gov/idg/api/v1/targets(8371)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(8371)/synonyms"},"_publications":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8371)/publications"},"_namespace":null},{"id":8372,"version":3,"created":1554916554000,"modified":1555038251000,"deprecated":false,"name":"Glutamate--cysteine ligase catalytic subunit","accession":"P48506","gene":"GCLC","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.489626596821958,"antibodyCount":293,"monoclonalCount":35,"pubmedCount":null,"jensenScore":294.624667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.76484622733062,"pubTatorScore":2.6563644886006044,"self":"https://pharos.nih.gov/idg/api/v1/targets(8372)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":542,"href":"https://pharos.nih.gov/idg/api/v1/targets(8372)/properties"},"_links":{"count":1175,"href":"https://pharos.nih.gov/idg/api/v1/targets(8372)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8372)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8372)/publications"},"_namespace":null},{"id":8373,"version":3,"created":1554916561000,"modified":1555038253000,"deprecated":false,"name":"Alpha-synuclein","accession":"P37840","gene":"SNCA","description":"May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.6393687245732647,"antibodyCount":1813,"monoclonalCount":525,"pubmedCount":null,"jensenScore":4224.920758,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":49.65342852728845,"pubTatorScore":3.6112361789068936,"self":"https://pharos.nih.gov/idg/api/v1/targets(8373)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1809,"href":"https://pharos.nih.gov/idg/api/v1/targets(8373)/properties"},"_links":{"count":2600,"href":"https://pharos.nih.gov/idg/api/v1/targets(8373)/links"},"_synonyms":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(8373)/synonyms"},"_publications":{"count":1372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8373)/publications"},"_namespace":null},{"id":8374,"version":3,"created":1554916602000,"modified":1555038260000,"deprecated":false,"name":"Ras-related protein Ral-B","accession":"P11234","gene":"RALB","description":"Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7107817381744108,"antibodyCount":228,"monoclonalCount":61,"pubmedCount":null,"jensenScore":50.92417,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":43.790140035974126,"pubTatorScore":1.662725466095503,"self":"https://pharos.nih.gov/idg/api/v1/targets(8374)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(8374)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(8374)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8374)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8374)/publications"},"_namespace":null},{"id":8375,"version":3,"created":1554916607000,"modified":1555038263000,"deprecated":false,"name":"VIP36-like protein","accession":"Q9H0V9","gene":"LMAN2L","description":"May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7263196750834797,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":52.717795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":33.70233214849232,"pubTatorScore":0.7621781993758471,"self":"https://pharos.nih.gov/idg/api/v1/targets(8375)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(8375)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(8375)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8375)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8375)/publications"},"_namespace":null},{"id":8376,"version":3,"created":1554916612000,"modified":1555038264000,"deprecated":false,"name":"Ras-related protein Ral-A","accession":"P11233","gene":"RALA","description":"Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.221882046803044,"antibodyCount":225,"monoclonalCount":67,"pubmedCount":null,"jensenScore":169.893038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":46.53188320411436,"pubTatorScore":2.4204165397440494,"self":"https://pharos.nih.gov/idg/api/v1/targets(8376)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":541,"href":"https://pharos.nih.gov/idg/api/v1/targets(8376)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8376)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8376)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8376)/publications"},"_namespace":null},{"id":8377,"version":3,"created":1554916617000,"modified":1555038266000,"deprecated":false,"name":"Nucleotide exchange factor SIL1","accession":"Q9H173","gene":"SIL1","description":"Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0419189344841286,"antibodyCount":216,"monoclonalCount":42,"pubmedCount":null,"jensenScore":1062.267968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":37.77867614853117,"pubTatorScore":1.7345712409654719,"self":"https://pharos.nih.gov/idg/api/v1/targets(8377)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8377)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(8377)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8377)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8377)/publications"},"_namespace":null},{"id":8378,"version":2,"created":1554916621000,"modified":1554916624000,"deprecated":false,"name":"ATP-binding cassette sub-family G member 4","accession":"Q9H172","gene":"ABCG4","description":"May be involved in macrophage lipid homeostasis.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.0305668466837066,"antibodyCount":155,"monoclonalCount":0,"pubmedCount":null,"jensenScore":101.103233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.00551113080841,"pubTatorScore":1.365027519757043,"self":"https://pharos.nih.gov/idg/api/v1/targets(8378)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(8378)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(8378)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8378)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8378)/publications"},"_namespace":null},{"id":8379,"version":2,"created":1554916624000,"modified":1554916627000,"deprecated":false,"name":"Cysteine/serine-rich nuclear protein 2","accession":"Q9H175","gene":"CSRNP2","description":"Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.26152145520753517,"antibodyCount":205,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.552632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.11956131182265,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8379)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(8379)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(8379)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8379)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8379)/publications"},"_namespace":null},{"id":8380,"version":3,"created":1554916628000,"modified":1555038271000,"deprecated":false,"name":"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase","accession":"Q92187","gene":"ST8SIA4","description":"Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.192797246346077,"antibodyCount":120,"monoclonalCount":7,"pubmedCount":null,"jensenScore":137.832713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":63,"knowledgeAvailability":37.78092007728463,"pubTatorScore":2.0215706613505855,"self":"https://pharos.nih.gov/idg/api/v1/targets(8380)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(8380)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(8380)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8380)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8380)/publications"},"_namespace":null},{"id":8381,"version":3,"created":1554916633000,"modified":1554916760000,"deprecated":false,"name":"Prostaglandin G/H synthase 1","accession":"P23219","gene":"PTGS1","description":"Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.2303494793275984,"antibodyCount":479,"monoclonalCount":96,"pubmedCount":null,"jensenScore":1641.284227,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.311182303271444,"pubTatorScore":2.8847127738965055,"self":"https://pharos.nih.gov/idg/api/v1/targets(8381)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":692,"href":"https://pharos.nih.gov/idg/api/v1/targets(8381)/properties"},"_links":{"count":1700,"href":"https://pharos.nih.gov/idg/api/v1/targets(8381)/links"},"_synonyms":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8381)/synonyms"},"_publications":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(8381)/publications"},"_namespace":null},{"id":8382,"version":2,"created":1554916763000,"modified":1554916766000,"deprecated":false,"name":"Transmembrane protein 168","accession":"Q9H0V1","gene":"TMEM168","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.24303804977203064,"antibodyCount":75,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.821429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.88375217399511,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8382)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(8382)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(8382)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8382)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8382)/publications"},"_namespace":null},{"id":8383,"version":2,"created":1554916766000,"modified":1554916770000,"deprecated":false,"name":"Z-DNA-binding protein 1","accession":"Q9H171","gene":"ZBP1","description":"Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.36961077585247,"antibodyCount":140,"monoclonalCount":21,"pubmedCount":null,"jensenScore":223.594424,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.097941611066535,"pubTatorScore":1.7518653983223509,"self":"https://pharos.nih.gov/idg/api/v1/targets(8383)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(8383)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(8383)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8383)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8383)/publications"},"_namespace":null},{"id":8384,"version":2,"created":1554916770000,"modified":1554916773000,"deprecated":false,"name":"Alpha-2,8-sialyltransferase 8B","accession":"Q92186","gene":"ST8SIA2","description":"May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.215261492655873,"antibodyCount":82,"monoclonalCount":26,"pubmedCount":null,"jensenScore":1661.446155,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.063120797235946,"pubTatorScore":2.3262269909624007,"self":"https://pharos.nih.gov/idg/api/v1/targets(8384)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(8384)/properties"},"_links":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(8384)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8384)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(8384)/publications"},"_namespace":null},{"id":8385,"version":3,"created":1554916773000,"modified":1555038272000,"deprecated":false,"name":"Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase","accession":"Q92185","gene":"ST8SIA1","description":"Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.525247320161808,"antibodyCount":40,"monoclonalCount":6,"pubmedCount":null,"jensenScore":35.427359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.11180314634266,"pubTatorScore":1.5662280728792608,"self":"https://pharos.nih.gov/idg/api/v1/targets(8385)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(8385)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(8385)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8385)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8385)/publications"},"_namespace":null},{"id":8386,"version":2,"created":1554916777000,"modified":1554916783000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial","accession":"P49821","gene":"NDUFV1","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.4280078630910091,"antibodyCount":177,"monoclonalCount":19,"pubmedCount":null,"jensenScore":26.393419,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.605762246864536,"pubTatorScore":1.4696629614663197,"self":"https://pharos.nih.gov/idg/api/v1/targets(8386)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(8386)/properties"},"_links":{"count":1235,"href":"https://pharos.nih.gov/idg/api/v1/targets(8386)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8386)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8386)/publications"},"_namespace":null},{"id":8387,"version":2,"created":1554916784000,"modified":1554916787000,"deprecated":false,"name":"Cell division cycle-associated protein 2","accession":"Q69YH5","gene":"CDCA2","description":"Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2088528045275488,"antibodyCount":84,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.733422,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.008684384300963,"pubTatorScore":1.2271982779255888,"self":"https://pharos.nih.gov/idg/api/v1/targets(8387)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(8387)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(8387)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8387)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8387)/publications"},"_namespace":null},{"id":8388,"version":3,"created":1554916788000,"modified":1555038273000,"deprecated":false,"name":"Mitochondrial brown fat uncoupling protein 1","accession":"P25874","gene":"UCP1","description":"Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1256515642371765,"antibodyCount":279,"monoclonalCount":63,"pubmedCount":null,"jensenScore":1273.244005,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.51366640867645,"pubTatorScore":2.727423272308451,"self":"https://pharos.nih.gov/idg/api/v1/targets(8388)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(8388)/properties"},"_links":{"count":549,"href":"https://pharos.nih.gov/idg/api/v1/targets(8388)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8388)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(8388)/publications"},"_namespace":null},{"id":8389,"version":3,"created":1554916791000,"modified":1555038275000,"deprecated":false,"name":"Melanoma-associated antigen B4","accession":"O15481","gene":"MAGEB4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.520701822696472,"antibodyCount":152,"monoclonalCount":17,"pubmedCount":null,"jensenScore":2.748189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":12.094626671857794,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(8389)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8389)/properties"},"_links":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(8389)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8389)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8389)/publications"},"_namespace":null},{"id":8390,"version":3,"created":1554916792000,"modified":1555038275000,"deprecated":false,"name":"Testis-specific protein TEX28","accession":"O15482","gene":"TEX28","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.6782148030124757,"antibodyCount":30,"monoclonalCount":6,"pubmedCount":null,"jensenScore":23.16809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":11.997024162183163,"pubTatorScore":0.946124602828674,"self":"https://pharos.nih.gov/idg/api/v1/targets(8390)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8390)/properties"},"_links":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8390)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8390)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8390)/publications"},"_namespace":null},{"id":8391,"version":3,"created":1554916793000,"modified":1555038275000,"deprecated":false,"name":"Melanoma-associated antigen B3","accession":"O15480","gene":"MAGEB3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6827465855689574,"antibodyCount":126,"monoclonalCount":9,"pubmedCount":null,"jensenScore":3.217099,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":12.26983767948672,"pubTatorScore":0.5542871691324731,"self":"https://pharos.nih.gov/idg/api/v1/targets(8391)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8391)/properties"},"_links":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8391)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8391)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8391)/publications"},"_namespace":null},{"id":8392,"version":2,"created":1554916794000,"modified":1554916796000,"deprecated":false,"name":"Zinc finger protein 700","accession":"Q9H0M5","gene":"ZNF700","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.041667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.77960011470111,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8392)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(8392)/properties"},"_links":{"count":832,"href":"https://pharos.nih.gov/idg/api/v1/targets(8392)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8392)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8392)/publications"},"_namespace":null},{"id":8393,"version":3,"created":1554916796000,"modified":1555038276000,"deprecated":false,"name":"Calpain-5","accession":"O15484","gene":"CAPN5","description":"Calcium-regulated non-lysosomal thiol-protease.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7032435736132052,"antibodyCount":163,"monoclonalCount":57,"pubmedCount":null,"jensenScore":50.340425,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.46587038651442,"pubTatorScore":1.6503993176485268,"self":"https://pharos.nih.gov/idg/api/v1/targets(8393)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(8393)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(8393)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8393)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8393)/publications"},"_namespace":null},{"id":8394,"version":2,"created":1554916800000,"modified":1554916802000,"deprecated":false,"name":"Zinc finger CW-type PWWP domain protein 1","accession":"Q9H0M4","gene":"ZCWPW1","description":null,"idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.6424331257944844,"antibodyCount":44,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.081229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.52114860740559,"pubTatorScore":0.7451738244271322,"self":"https://pharos.nih.gov/idg/api/v1/targets(8394)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(8394)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(8394)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8394)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8394)/publications"},"_namespace":null},{"id":8395,"version":3,"created":1554916802000,"modified":1555038277000,"deprecated":false,"name":"NEDD4-like E3 ubiquitin-protein ligase WWP1","accession":"Q9H0M0","gene":"WWP1","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.681091240595711,"antibodyCount":122,"monoclonalCount":33,"pubmedCount":null,"jensenScore":48.998975,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.299284167489674,"pubTatorScore":1.6326173442422642,"self":"https://pharos.nih.gov/idg/api/v1/targets(8395)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(8395)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(8395)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8395)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8395)/publications"},"_namespace":null},{"id":8396,"version":2,"created":1554916807000,"modified":1554916810000,"deprecated":false,"name":"Dermatopontin","accession":"Q07507","gene":"DPT","description":"Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.115901651685986,"antibodyCount":89,"monoclonalCount":10,"pubmedCount":null,"jensenScore":1302.129866,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.143593210119114,"pubTatorScore":1.5092558579478421,"self":"https://pharos.nih.gov/idg/api/v1/targets(8396)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(8396)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(8396)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8396)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8396)/publications"},"_namespace":null},{"id":8397,"version":2,"created":1554916811000,"modified":1554916812000,"deprecated":false,"name":"Melanoma-associated antigen B2","accession":"O15479","gene":"MAGEB2","description":"May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0716221242194703,"antibodyCount":140,"monoclonalCount":3,"pubmedCount":null,"jensenScore":12.48646,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.406943395093045,"pubTatorScore":1.1215332867439292,"self":"https://pharos.nih.gov/idg/api/v1/targets(8397)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(8397)/properties"},"_links":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8397)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8397)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8397)/publications"},"_namespace":null},{"id":8398,"version":2,"created":1554916812000,"modified":1554916816000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein SOWAHC","accession":"Q53LP3","gene":"SOWAHC","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17800024900269765,"antibodyCount":90,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.705514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.561656085425877,"pubTatorScore":0.06279099689576256,"self":"https://pharos.nih.gov/idg/api/v1/targets(8398)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(8398)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(8398)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8398)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8398)/publications"},"_namespace":null},{"id":8399,"version":2,"created":1554916817000,"modified":1554916818000,"deprecated":false,"name":"Olfactory receptor 6B2","accession":"Q6IFH4","gene":"OR6B2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.0,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.0,"patentCount":213,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.154944997241394,"pubTatorScore":2.381656477175141,"self":"https://pharos.nih.gov/idg/api/v1/targets(8399)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8399)/properties"},"_links":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8399)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8399)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8399)/publications"},"_namespace":null},{"id":8400,"version":2,"created":1554916818000,"modified":1554916821000,"deprecated":false,"name":"Regulator of G-protein signaling 16","accession":"O15492","gene":"RGS16","description":"Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6183108744129382,"antibodyCount":185,"monoclonalCount":60,"pubmedCount":null,"jensenScore":43.323848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.98602363541976,"pubTatorScore":1.5779311915027516,"self":"https://pharos.nih.gov/idg/api/v1/targets(8400)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(8400)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(8400)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8400)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8400)/publications"},"_namespace":null},{"id":8401,"version":3,"created":1554916822000,"modified":1555038282000,"deprecated":false,"name":"Group 10 secretory phospholipase A2","accession":"O15496","gene":"PLA2G10","description":"PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.4122576142947607,"antibodyCount":57,"monoclonalCount":12,"pubmedCount":null,"jensenScore":298.190734,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":52,"knowledgeAvailability":28.718111676075473,"pubTatorScore":2.261493381091286,"self":"https://pharos.nih.gov/idg/api/v1/targets(8401)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(8401)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(8401)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8401)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8401)/publications"},"_namespace":null},{"id":8402,"version":3,"created":1554916832000,"modified":1555038283000,"deprecated":false,"name":"Cleavage stimulation factor subunit 2 tau variant","accession":"Q9H0L4","gene":"CSTF2T","description":"May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.873341133311765,"antibodyCount":128,"monoclonalCount":4,"pubmedCount":null,"jensenScore":8.937024,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":40.76278544851665,"pubTatorScore":0.4240255925663498,"self":"https://pharos.nih.gov/idg/api/v1/targets(8402)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(8402)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(8402)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8402)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8402)/publications"},"_namespace":null},{"id":8403,"version":3,"created":1554916836000,"modified":1555038285000,"deprecated":false,"name":"Fibrinogen-like protein 1","accession":"Q08830","gene":"FGL1","description":"Has hepatocyte mitogenic activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3841025295509886,"antibodyCount":239,"monoclonalCount":32,"pubmedCount":null,"jensenScore":26.438218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":60,"knowledgeAvailability":25.99706750842151,"pubTatorScore":1.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(8403)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(8403)/properties"},"_links":{"count":808,"href":"https://pharos.nih.gov/idg/api/v1/targets(8403)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8403)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8403)/publications"},"_namespace":null},{"id":8404,"version":2,"created":1554916839000,"modified":1554916859000,"deprecated":false,"name":"Adenylate cyclase type 1","accession":"Q08828","gene":"ADCY1","description":"Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.6165672328872898,"antibodyCount":134,"monoclonalCount":0,"pubmedCount":null,"jensenScore":45.250946,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.06075689594244,"pubTatorScore":2.366157637146982,"self":"https://pharos.nih.gov/idg/api/v1/targets(8404)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(8404)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(8404)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8404)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8404)/publications"},"_namespace":null},{"id":8405,"version":3,"created":1554916860000,"modified":1555038286000,"deprecated":false,"name":"Glycogenin-2","accession":"O15488","gene":"GYG2","description":"Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9698039992686007,"antibodyCount":145,"monoclonalCount":21,"pubmedCount":null,"jensenScore":91.962245,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":26.157977182070876,"pubTatorScore":1.4819201328289644,"self":"https://pharos.nih.gov/idg/api/v1/targets(8405)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8405)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(8405)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8405)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8405)/publications"},"_namespace":null},{"id":8406,"version":3,"created":1554916865000,"modified":1555038288000,"deprecated":false,"name":"Radial spoke head protein 6 homolog A","accession":"Q9H0K4","gene":"RSPH6A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0418311269020926,"antibodyCount":29,"monoclonalCount":13,"pubmedCount":null,"jensenScore":11.172054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":31,"knowledgeAvailability":20.330285312565195,"pubTatorScore":0.7703259023433359,"self":"https://pharos.nih.gov/idg/api/v1/targets(8406)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(8406)/properties"},"_links":{"count":647,"href":"https://pharos.nih.gov/idg/api/v1/targets(8406)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8406)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8406)/publications"},"_namespace":null},{"id":8407,"version":2,"created":1554916868000,"modified":1554916873000,"deprecated":false,"name":"Pseudouridylate synthase 7 homolog-like protein","accession":"Q9H0K6","gene":"PUS7L","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":34,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.59556122750581,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8407)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8407)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(8407)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8407)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8407)/publications"},"_namespace":null},{"id":8408,"version":2,"created":1554916873000,"modified":1554916879000,"deprecated":false,"name":"Serine/threonine-protein kinase SIK2","accession":"Q9H0K1","gene":"SIK2","description":"Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.5071882248270287,"antibodyCount":233,"monoclonalCount":50,"pubmedCount":null,"jensenScore":36.530262,"patentCount":5126,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.22143191971726,"pubTatorScore":1.2503918454505345,"self":"https://pharos.nih.gov/idg/api/v1/targets(8408)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(8408)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(8408)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8408)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8408)/publications"},"_namespace":null},{"id":8409,"version":2,"created":1554916880000,"modified":1554916881000,"deprecated":false,"name":"Immunoglobulin heavy variable 2-5","accession":"P01817","gene":"IGHV2-5","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.382154063438813,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8409)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8409)/properties"},"_links":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(8409)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8409)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8409)/publications"},"_namespace":null},{"id":8410,"version":2,"created":1554916881000,"modified":1554916881000,"deprecated":false,"name":"Immunoglobulin heavy variable 2-70","accession":"P01814","gene":"IGHV2-70","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.441149558667087,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8410)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8410)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8410)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8410)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8410)/publications"},"_namespace":null},{"id":8411,"version":3,"created":1554916881000,"modified":1555038289000,"deprecated":false,"name":"Synaptobrevin homolog YKT6","accession":"O15498","gene":"YKT6","description":"Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5885242410611031,"antibodyCount":37,"monoclonalCount":7,"pubmedCount":null,"jensenScore":38.981865,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.61670833721633,"pubTatorScore":1.4616119327661448,"self":"https://pharos.nih.gov/idg/api/v1/targets(8411)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(8411)/properties"},"_links":{"count":1120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8411)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8411)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8411)/publications"},"_namespace":null},{"id":8412,"version":2,"created":1554916885000,"modified":1554916886000,"deprecated":false,"name":"Homeobox protein goosecoid-2","accession":"O15499","gene":"GSC2","description":"May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.2520435291825145,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":18.944027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.088606107241453,"pubTatorScore":0.9353393095108588,"self":"https://pharos.nih.gov/idg/api/v1/targets(8412)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8412)/properties"},"_links":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(8412)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8412)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8412)/publications"},"_namespace":null},{"id":8413,"version":2,"created":1554916886000,"modified":1554916886000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 12","accession":"C9JPN9","gene":"USP17L12","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.332927678990555,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8413)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8413)/properties"},"_links":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8413)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8413)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8413)/publications"},"_namespace":null},{"id":8414,"version":2,"created":1554916886000,"modified":1554916887000,"deprecated":false,"name":"Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein","accession":"Q5K130","gene":"CLLU1OS","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.308382123983659,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8414)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8414)/properties"},"_links":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(8414)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8414)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8414)/publications"},"_namespace":null},{"id":8415,"version":3,"created":1554916887000,"modified":1555038291000,"deprecated":false,"name":"Poly [ADP-ribose] polymerase 12","accession":"Q9H0J9","gene":"PARP12","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.557215453769728,"antibodyCount":60,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.954829,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":35.19565327996964,"pubTatorScore":0.3373078807877475,"self":"https://pharos.nih.gov/idg/api/v1/targets(8415)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(8415)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(8415)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8415)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8415)/publications"},"_namespace":null},{"id":8416,"version":2,"created":1554916891000,"modified":1554916893000,"deprecated":false,"name":"Glutamine-rich protein 2","accession":"Q9H0J4","gene":"QRICH2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.56609424934713,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8416)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(8416)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(8416)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8416)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8416)/publications"},"_namespace":null},{"id":8417,"version":2,"created":1554916894000,"modified":1554916895000,"deprecated":false,"name":"Chronic lymphocytic leukemia up-regulated protein 1","accession":"Q5K131","gene":"CLLU1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0086508768653684,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.957207,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.654512561026916,"pubTatorScore":0.6989700043360189,"self":"https://pharos.nih.gov/idg/api/v1/targets(8417)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8417)/properties"},"_links":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(8417)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8417)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8417)/publications"},"_namespace":null},{"id":8418,"version":2,"created":1554916895000,"modified":1554916898000,"deprecated":false,"name":"Uncharacterized protein KIAA1211-like","accession":"Q6NV74","gene":"KIAA1211L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.859718512999518,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8418)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(8418)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(8418)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8418)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8418)/publications"},"_namespace":null},{"id":8419,"version":2,"created":1554916899000,"modified":1554916901000,"deprecated":false,"name":"Probable G-protein coupled receptor 153","accession":"Q6NV75","gene":"GPR153","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.20394368793437784,"antibodyCount":177,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.944445,"patentCount":1136,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.005327462814254,"pubTatorScore":0.5584989308660755,"self":"https://pharos.nih.gov/idg/api/v1/targets(8419)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(8419)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(8419)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8419)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8419)/publications"},"_namespace":null},{"id":8420,"version":3,"created":1554916902000,"modified":1555038292000,"deprecated":false,"name":"Transketolase-like protein 2","accession":"Q9H0I9","gene":"TKTL2","description":"Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7609248599903193,"antibodyCount":107,"monoclonalCount":7,"pubmedCount":null,"jensenScore":3.822883,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":17.740237250034415,"pubTatorScore":0.38321645233779217,"self":"https://pharos.nih.gov/idg/api/v1/targets(8420)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(8420)/properties"},"_links":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(8420)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8420)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8420)/publications"},"_namespace":null},{"id":8421,"version":2,"created":1554916904000,"modified":1554916904000,"deprecated":false,"name":"Olfactory receptor 52E8","accession":"Q6IFG1","gene":"OR52E8","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":215,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.921800195220739,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8421)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8421)/properties"},"_links":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8421)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8421)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8421)/publications"},"_namespace":null},{"id":8422,"version":3,"created":1554916904000,"modified":1555038293000,"deprecated":false,"name":"Metallophosphoesterase domain-containing protein 1","accession":"O15442","gene":"MPPED1","description":"May have metallophosphoesterase activity (in vitro).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5740312622990379,"antibodyCount":95,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.741884,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":21.7868290223665,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8422)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(8422)/properties"},"_links":{"count":705,"href":"https://pharos.nih.gov/idg/api/v1/targets(8422)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8422)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8422)/publications"},"_namespace":null},{"id":8423,"version":2,"created":1554916907000,"modified":1554916910000,"deprecated":false,"name":"Coiled-coil domain-containing protein 171","accession":"Q6TFL3","gene":"CCDC171","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.1856365789886192,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.914146148309584,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(8423)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(8423)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(8423)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8423)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8423)/publications"},"_namespace":null},{"id":8424,"version":2,"created":1554916911000,"modified":1554916914000,"deprecated":false,"name":"Kelch-like protein 24","accession":"Q6TFL4","gene":"KLHL24","description":"Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0243832995310598,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.156654,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.42709953096526,"pubTatorScore":0.5921237724585184,"self":"https://pharos.nih.gov/idg/api/v1/targets(8424)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(8424)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(8424)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8424)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8424)/publications"},"_namespace":null},{"id":8425,"version":2,"created":1554916915000,"modified":1554916920000,"deprecated":false,"name":"Multidrug resistance-associated protein 5","accession":"O15440","gene":"ABCC5","description":"Acts as a multispecific organic anion pump which can transport nucleotide analogs.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.1008495058806704,"antibodyCount":262,"monoclonalCount":88,"pubmedCount":null,"jensenScore":119.25092,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.16559011786417,"pubTatorScore":2.013617321896229,"self":"https://pharos.nih.gov/idg/api/v1/targets(8425)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(8425)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(8425)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(8425)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8425)/publications"},"_namespace":null},{"id":8426,"version":3,"created":1554916921000,"modified":1555038294000,"deprecated":false,"name":"FXYD domain-containing ion transport regulator 6","accession":"Q9H0Q3","gene":"FXYD6","description":null,"idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.2210196771015271,"antibodyCount":79,"monoclonalCount":3,"pubmedCount":null,"jensenScore":17.054325,"patentCount":1000,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":30.383094373432968,"pubTatorScore":1.1960017411057557,"self":"https://pharos.nih.gov/idg/api/v1/targets(8426)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(8426)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(8426)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8426)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8426)/publications"},"_namespace":null},{"id":8427,"version":2,"created":1554916926000,"modified":1554916929000,"deprecated":false,"name":"Protein FAM49A","accession":"Q9H0Q0","gene":"FAM49A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.1060533908555131,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.60119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.439168127410824,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8427)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(8427)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(8427)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8427)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8427)/publications"},"_namespace":null},{"id":8428,"version":2,"created":1554916930000,"modified":1554916934000,"deprecated":false,"name":"Aspartate aminotransferase, mitochondrial","accession":"P00505","gene":"GOT2","description":"Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.2362950448407615,"antibodyCount":450,"monoclonalCount":90,"pubmedCount":null,"jensenScore":1435.013349,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.51667585841706,"pubTatorScore":2.275578986386176,"self":"https://pharos.nih.gov/idg/api/v1/targets(8428)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":496,"href":"https://pharos.nih.gov/idg/api/v1/targets(8428)/properties"},"_links":{"count":1153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8428)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8428)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8428)/publications"},"_namespace":null},{"id":8429,"version":2,"created":1554916935000,"modified":1554916935000,"deprecated":false,"name":"Immunoglobulin kappa constant","accession":"P01834","gene":"IGKC","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.123847410199883,"pubTatorScore":0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8429)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8429)/properties"},"_links":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8429)/links"},"_synonyms":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(8429)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8429)/publications"},"_namespace":null},{"id":8430,"version":3,"created":1554916936000,"modified":1555038296000,"deprecated":false,"name":"Rhombotin-1","accession":"P25800","gene":"LMO1","description":"May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5767446208540221,"antibodyCount":107,"monoclonalCount":50,"pubmedCount":null,"jensenScore":38.970723,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":31.32892346759702,"pubTatorScore":1.4474684719374378,"self":"https://pharos.nih.gov/idg/api/v1/targets(8430)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(8430)/properties"},"_links":{"count":679,"href":"https://pharos.nih.gov/idg/api/v1/targets(8430)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8430)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8430)/publications"},"_namespace":null},{"id":8431,"version":3,"created":1554916939000,"modified":1555038297000,"deprecated":false,"name":"Polymeric immunoglobulin receptor","accession":"P01833","gene":"PIGR","description":"This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3793601641201705,"antibodyCount":317,"monoclonalCount":57,"pubmedCount":null,"jensenScore":259.441116,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.78772532359977,"pubTatorScore":2.2397639432910927,"self":"https://pharos.nih.gov/idg/api/v1/targets(8431)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":393,"href":"https://pharos.nih.gov/idg/api/v1/targets(8431)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(8431)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8431)/synonyms"},"_publications":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8431)/publications"},"_namespace":null},{"id":8432,"version":2,"created":1554916943000,"modified":1554916947000,"deprecated":false,"name":"Probable low affinity copper uptake protein 2","accession":"O15432","gene":"SLC31A2","description":"Involved in low-affinity copper uptake.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.6863312089879305,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":54.974363,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.88890203219254,"pubTatorScore":1.403467766404974,"self":"https://pharos.nih.gov/idg/api/v1/targets(8432)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(8432)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(8432)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8432)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8432)/publications"},"_namespace":null},{"id":8433,"version":2,"created":1554916948000,"modified":1554916952000,"deprecated":false,"name":"Canalicular multispecific organic anion transporter 2","accession":"O15438","gene":"ABCC3","description":"May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.460319322390495,"antibodyCount":214,"monoclonalCount":45,"pubmedCount":null,"jensenScore":287.379086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.52494618559247,"pubTatorScore":2.650060056351567,"self":"https://pharos.nih.gov/idg/api/v1/targets(8433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(8433)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(8433)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(8433)/synonyms"},"_publications":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8433)/publications"},"_namespace":null},{"id":8434,"version":2,"created":1554916953000,"modified":1554916959000,"deprecated":false,"name":"Multidrug resistance-associated protein 4","accession":"O15439","gene":"ABCC4","description":"May be an organic anion pump relevant to cellular detoxification.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.5600092566051256,"antibodyCount":352,"monoclonalCount":118,"pubmedCount":null,"jensenScore":341.612838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":56.25442592928168,"pubTatorScore":2.377574740211105,"self":"https://pharos.nih.gov/idg/api/v1/targets(8434)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":497,"href":"https://pharos.nih.gov/idg/api/v1/targets(8434)/properties"},"_links":{"count":1135,"href":"https://pharos.nih.gov/idg/api/v1/targets(8434)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(8434)/synonyms"},"_publications":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8434)/publications"},"_namespace":null},{"id":8435,"version":2,"created":1554916960000,"modified":1554916960000,"deprecated":false,"name":"Next to BRCA1 gene 2 protein","accession":"O15453","gene":"NBR2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.752535631787254,"pubTatorScore":0.879860127183601,"self":"https://pharos.nih.gov/idg/api/v1/targets(8435)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8435)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8435)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8435)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8435)/publications"},"_namespace":null},{"id":8436,"version":2,"created":1554916960000,"modified":1554916963000,"deprecated":false,"name":"Beta-soluble NSF attachment protein","accession":"Q9H115","gene":"NAPB","description":"Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8129133675002178,"antibodyCount":84,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.555556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.80898874526662,"pubTatorScore":1.3199978109836812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(8436)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(8436)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8436)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8436)/publications"},"_namespace":null},{"id":8437,"version":3,"created":1554916964000,"modified":1555038302000,"deprecated":false,"name":"Cystatin-like 1","accession":"Q9H114","gene":"CSTL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5378190987647773,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":49,"knowledgeAvailability":13.215383497021985,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(8437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8437)/properties"},"_links":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(8437)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8437)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8437)/publications"},"_namespace":null},{"id":8438,"version":2,"created":1554916965000,"modified":1554916965000,"deprecated":false,"name":"Putative uncharacterized protein encoded by AGPAT4-IT1","accession":"Q9H0P7","gene":"AGPAT4-IT1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.891231073527369,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8438)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8438)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8438)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8438)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8438)/publications"},"_namespace":null},{"id":8439,"version":2,"created":1554916965000,"modified":1554916968000,"deprecated":false,"name":"GDNF-inducible zinc finger protein 1","accession":"Q9H116","gene":"GZF1","description":"Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.34461056364079073,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.356259,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.52739900942236,"pubTatorScore":0.5163149316871367,"self":"https://pharos.nih.gov/idg/api/v1/targets(8439)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(8439)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(8439)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8439)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8439)/publications"},"_namespace":null},{"id":8440,"version":3,"created":1554916969000,"modified":1555038302000,"deprecated":false,"name":"Cytosolic 5'-nucleotidase 3A","accession":"Q9H0P0","gene":"NT5C3A","description":"Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.991116352024712,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":92.692614,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.3584001026554,"pubTatorScore":2.7645405573334214,"self":"https://pharos.nih.gov/idg/api/v1/targets(8440)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(8440)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(8440)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(8440)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(8440)/publications"},"_namespace":null},{"id":8441,"version":2,"created":1554916973000,"modified":1554916974000,"deprecated":false,"name":"Cystatin-11","accession":"Q9H112","gene":"CST11","description":"Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0469965614353822,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.545381,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.965411586800496,"pubTatorScore":0.5228787018508873,"self":"https://pharos.nih.gov/idg/api/v1/targets(8441)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8441)/properties"},"_links":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8441)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8441)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8441)/publications"},"_namespace":null},{"id":8442,"version":2,"created":1554916974000,"modified":1554916977000,"deprecated":false,"name":"Protein S100-P","accession":"P25815","gene":"S100P","description":"May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.301943234163223,"antibodyCount":190,"monoclonalCount":55,"pubmedCount":null,"jensenScore":22.977808,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.583251803965652,"pubTatorScore":2.151500385617801,"self":"https://pharos.nih.gov/idg/api/v1/targets(8442)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(8442)/properties"},"_links":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(8442)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8442)/synonyms"},"_publications":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8442)/publications"},"_namespace":null},{"id":8443,"version":2,"created":1554916978000,"modified":1554916979000,"deprecated":false,"name":"Immunoglobulin heavy variable 4-59","accession":"P01825","gene":"IGHV4-59","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.6485191169715938,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8443)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8443)/properties"},"_links":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(8443)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8443)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8443)/publications"},"_namespace":null},{"id":8444,"version":2,"created":1554916980000,"modified":1554916981000,"deprecated":false,"name":"Immunoglobulin heavy variable 4-39","accession":"P01824","gene":"IGHV4-39","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.6354861924715394,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8444)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8444)/properties"},"_links":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(8444)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8444)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8444)/publications"},"_namespace":null},{"id":8445,"version":2,"created":1554916981000,"modified":1554916984000,"deprecated":false,"name":"DNA-directed RNA polymerase I subunit RPA34","accession":"O15446","gene":"CD3EAP","description":"Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.13064006494813,"antibodyCount":209,"monoclonalCount":37,"pubmedCount":null,"jensenScore":13.782945,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.61921759186945,"pubTatorScore":1.2532860419848668,"self":"https://pharos.nih.gov/idg/api/v1/targets(8445)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(8445)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(8445)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8445)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8445)/publications"},"_namespace":null},{"id":8446,"version":3,"created":1554916985000,"modified":1555038303000,"deprecated":false,"name":"C-C motif chemokine 25","accession":"O15444","gene":"CCL25","description":"Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7978382076589376,"antibodyCount":303,"monoclonalCount":80,"pubmedCount":null,"jensenScore":59.134408,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":23.65933315500571,"pubTatorScore":1.8368255438761836,"self":"https://pharos.nih.gov/idg/api/v1/targets(8446)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8446)/properties"},"_links":{"count":523,"href":"https://pharos.nih.gov/idg/api/v1/targets(8446)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8446)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8446)/publications"},"_namespace":null},{"id":8447,"version":2,"created":1554916987000,"modified":1554916991000,"deprecated":false,"name":"Inverted formin-2","accession":"Q27J81","gene":"INF2","description":"Severs actin filaments and accelerates their polymerization and depolymerization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2366408999914116,"antibodyCount":135,"monoclonalCount":3,"pubmedCount":null,"jensenScore":182.339804,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.15634020467403,"pubTatorScore":1.964519817709947,"self":"https://pharos.nih.gov/idg/api/v1/targets(8447)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(8447)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8447)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8447)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8447)/publications"},"_namespace":null},{"id":8448,"version":3,"created":1554916992000,"modified":1555038307000,"deprecated":false,"name":"Prolyl 4-hydroxylase subunit alpha-2","accession":"O15460","gene":"P4HA2","description":"Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0400632143423438,"antibodyCount":76,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.891132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":74,"knowledgeAvailability":42.61009790151036,"pubTatorScore":0.9222711050780086,"self":"https://pharos.nih.gov/idg/api/v1/targets(8448)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(8448)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(8448)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8448)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8448)/publications"},"_namespace":null},{"id":8449,"version":3,"created":1554916996000,"modified":1555038308000,"deprecated":false,"name":"Glycogen [starch] synthase, muscle","accession":"P13807","gene":"GYS1","description":"Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.1815062200876785,"antibodyCount":227,"monoclonalCount":39,"pubmedCount":null,"jensenScore":151.093677,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.35205026635451,"pubTatorScore":1.7844451666649541,"self":"https://pharos.nih.gov/idg/api/v1/targets(8449)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":499,"href":"https://pharos.nih.gov/idg/api/v1/targets(8449)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8449)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8449)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8449)/publications"},"_namespace":null},{"id":8450,"version":3,"created":1554917012000,"modified":1555038309000,"deprecated":false,"name":"Electron transfer flavoprotein subunit alpha, mitochondrial","accession":"P13804","gene":"ETFA","description":"Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5040174265856305,"antibodyCount":241,"monoclonalCount":12,"pubmedCount":null,"jensenScore":315.317565,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":45.94063293046199,"pubTatorScore":2.160864947743618,"self":"https://pharos.nih.gov/idg/api/v1/targets(8450)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(8450)/properties"},"_links":{"count":1207,"href":"https://pharos.nih.gov/idg/api/v1/targets(8450)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8450)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8450)/publications"},"_namespace":null},{"id":8451,"version":3,"created":1554917017000,"modified":1555038312000,"deprecated":false,"name":"Troponin T, slow skeletal muscle","accession":"P13805","gene":"TNNT1","description":"Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.469045107028681,"antibodyCount":148,"monoclonalCount":37,"pubmedCount":null,"jensenScore":2926.25323,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":30.73456555606158,"pubTatorScore":2.734323090185418,"self":"https://pharos.nih.gov/idg/api/v1/targets(8451)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(8451)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(8451)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8451)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8451)/publications"},"_namespace":null},{"id":8452,"version":3,"created":1554917022000,"modified":1555038313000,"deprecated":false,"name":"von Willebrand factor A domain-containing protein 2","accession":"Q5GFL6","gene":"VWA2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0517954281862134,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.330705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":21.662662417935657,"pubTatorScore":0.864807629026147,"self":"https://pharos.nih.gov/idg/api/v1/targets(8452)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(8452)/properties"},"_links":{"count":750,"href":"https://pharos.nih.gov/idg/api/v1/targets(8452)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8452)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8452)/publications"},"_namespace":null},{"id":8453,"version":3,"created":1554917025000,"modified":1555038314000,"deprecated":false,"name":"Signal-regulatory protein delta","accession":"Q9H106","gene":"SIRPD","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.1139433523068367,"antibodyCount":75,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":13.048388407942122,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8453)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(8453)/properties"},"_links":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(8453)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8453)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8453)/publications"},"_namespace":null},{"id":8454,"version":2,"created":1554917027000,"modified":1554917029000,"deprecated":false,"name":"Immunoglobulin heavy constant gamma 2","accession":"P01859","gene":"IGHG2","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.751810946642493,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8454)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(8454)/properties"},"_links":{"count":601,"href":"https://pharos.nih.gov/idg/api/v1/targets(8454)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8454)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8454)/publications"},"_namespace":null},{"id":8455,"version":2,"created":1554917029000,"modified":1554917029000,"deprecated":false,"name":"Phagocytosis-stimulating peptide","accession":"P01858","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8455)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8455)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8455)/links"},"_synonyms":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8455)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8455)/publications"},"_namespace":null},{"id":8456,"version":2,"created":1554917029000,"modified":1554917032000,"deprecated":false,"name":"Immunoglobulin heavy constant gamma 1","accession":"P01857","gene":"IGHG1","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.372851647074892,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(8456)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/properties"},"_links":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/links"},"_synonyms":{"count":831,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8456)/publications"},"_namespace":null},{"id":8457,"version":2,"created":1554917033000,"modified":1554917035000,"deprecated":false,"name":"MutS protein homolog 4","accession":"O15457","gene":"MSH4","description":"Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8506527739700103,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":67.466098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.4118508485133,"pubTatorScore":1.473390363468887,"self":"https://pharos.nih.gov/idg/api/v1/targets(8457)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8457)/publications"},"_namespace":null},{"id":8458,"version":2,"created":1554917036000,"modified":1554917037000,"deprecated":false,"name":"Immunoglobulin heavy constant epsilon","accession":"P01854","gene":"IGHE","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.264043941865783,"pubTatorScore":1.0014452264457927,"self":"https://pharos.nih.gov/idg/api/v1/targets(8458)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/properties"},"_links":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8458)/publications"},"_namespace":null},{"id":8459,"version":3,"created":1554917037000,"modified":1555038315000,"deprecated":false,"name":"Toll-like receptor 3","accession":"O15455","gene":"TLR3","description":"Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.090615155026671,"antibodyCount":874,"monoclonalCount":351,"pubmedCount":null,"jensenScore":1260.402486,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.02481535947711,"pubTatorScore":2.8987585255713544,"self":"https://pharos.nih.gov/idg/api/v1/targets(8459)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/properties"},"_links":{"count":1538,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/synonyms"},"_publications":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(8459)/publications"},"_namespace":null},{"id":8460,"version":2,"created":1554917045000,"modified":1554917048000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit C-like protein","accession":"B5ME19","gene":"EIF3CL","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.889968962738322,"pubTatorScore":-0.3429747592865546,"self":"https://pharos.nih.gov/idg/api/v1/targets(8460)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8460)/publications"},"_namespace":null},{"id":8461,"version":2,"created":1554917049000,"modified":1554917049000,"deprecated":false,"name":"T-cell receptor beta-1 chain C region","accession":"P01850","gene":"TRBC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.4243740426214195,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8461)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/links"},"_synonyms":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8461)/publications"},"_namespace":null},{"id":8462,"version":3,"created":1554917049000,"modified":1555038318000,"deprecated":false,"name":"Pterin-4-alpha-carbinolamine dehydratase 2","accession":"Q9H0N5","gene":"PCBD2","description":"Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6520620662636819,"antibodyCount":39,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.666677,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.832539090540465,"pubTatorScore":0.3832166320459405,"self":"https://pharos.nih.gov/idg/api/v1/targets(8462)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8462)/publications"},"_namespace":null},{"id":8463,"version":3,"created":1554917052000,"modified":1555038319000,"deprecated":false,"name":"Ras-related protein Rab-6C","accession":"Q9H0N0","gene":"RAB6C","description":"May be involved in the regulation of centrosome duplication and cell cycle progression.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8574484859173215,"antibodyCount":82,"monoclonalCount":1,"pubmedCount":null,"jensenScore":8.999534,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":21.7748814371019,"pubTatorScore":0.9164539485499251,"self":"https://pharos.nih.gov/idg/api/v1/targets(8463)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8463)/publications"},"_namespace":null},{"id":8464,"version":4,"created":1554917055000,"modified":1555038320000,"deprecated":false,"name":"Tyrosine-protein kinase ABL1","accession":"P00519","gene":"ABL1","description":"Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.5185430385829926,"antibodyCount":1661,"monoclonalCount":101,"pubmedCount":null,"jensenScore":3418.508528,"patentCount":329475,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.116686108180204,"pubTatorScore":3.6638749284355425,"self":"https://pharos.nih.gov/idg/api/v1/targets(8464)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1323,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/properties"},"_links":{"count":2356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/links"},"_synonyms":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/synonyms"},"_publications":{"count":696,"href":"https://pharos.nih.gov/idg/api/v1/targets(8464)/publications"},"_namespace":null},{"id":8465,"version":3,"created":1554917272000,"modified":1555038326000,"deprecated":false,"name":"T-cell receptor alpha chain C region","accession":"P01848","gene":"TRAC","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":15.843069165144506,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8465)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/properties"},"_links":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/links"},"_synonyms":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8465)/publications"},"_namespace":null},{"id":8466,"version":2,"created":1554917274000,"modified":1554917275000,"deprecated":false,"name":"C-C motif chemokine 16","accession":"O15467","gene":"CCL16","description":"Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4319555894498075,"antibodyCount":267,"monoclonalCount":128,"pubmedCount":null,"jensenScore":263.567976,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.587625224026148,"pubTatorScore":2.1500030177954432,"self":"https://pharos.nih.gov/idg/api/v1/targets(8466)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/properties"},"_links":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8466)/publications"},"_namespace":null},{"id":8467,"version":3,"created":1554917275000,"modified":1555038326000,"deprecated":false,"name":"Alpha-2,8-sialyltransferase 8E","accession":"O15466","gene":"ST8SIA5","description":"May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.577874607822833,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.533333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.945095661519453,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8467)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8467)/publications"},"_namespace":null},{"id":8468,"version":3,"created":1554917278000,"modified":1555038327000,"deprecated":false,"name":"WD repeat and FYVE domain-containing protein 3","accession":"Q8IZQ1","gene":"WDFY3","description":"Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3246048127235512,"antibodyCount":118,"monoclonalCount":7,"pubmedCount":null,"jensenScore":21.989354,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":43.91445225384033,"pubTatorScore":1.1616531352583428,"self":"https://pharos.nih.gov/idg/api/v1/targets(8468)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8468)/publications"},"_namespace":null},{"id":8469,"version":2,"created":1554917283000,"modified":1554917285000,"deprecated":false,"name":"Selenoprotein H","accession":"Q8IZQ5","gene":"SELENOH","description":"May be involved in a redox-related process.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.523025851256227,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.0306128760730422,"self":"https://pharos.nih.gov/idg/api/v1/targets(8469)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8469)/publications"},"_namespace":null},{"id":8470,"version":2,"created":1554917286000,"modified":1554917289000,"deprecated":false,"name":"mRNA decay activator protein ZFP36L1","accession":"Q07352","gene":"ZFP36L1","description":"Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5133920138747357,"antibodyCount":285,"monoclonalCount":26,"pubmedCount":null,"jensenScore":38.648147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.75927551228342,"pubTatorScore":1.441070763718873,"self":"https://pharos.nih.gov/idg/api/v1/targets(8470)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8470)/publications"},"_namespace":null},{"id":8471,"version":2,"created":1554917290000,"modified":1554917294000,"deprecated":false,"name":"Myocardin","accession":"Q8IZQ8","gene":"MYOCD","description":"Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3780078451984834,"antibodyCount":84,"monoclonalCount":7,"pubmedCount":null,"jensenScore":242.669289,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.55341773309332,"pubTatorScore":1.8855646743928407,"self":"https://pharos.nih.gov/idg/api/v1/targets(8471)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8471)/publications"},"_namespace":null},{"id":8472,"version":3,"created":1554917295000,"modified":1555038329000,"deprecated":false,"name":"CASP8 and FADD-like apoptosis regulator","accession":"O15519","gene":"CFLAR","description":"Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8979266406172157,"antibodyCount":683,"monoclonalCount":178,"pubmedCount":null,"jensenScore":871.651564,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":50.84810880552975,"pubTatorScore":3.2975145185297956,"self":"https://pharos.nih.gov/idg/api/v1/targets(8472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":671,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/properties"},"_links":{"count":1348,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/links"},"_synonyms":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/synonyms"},"_publications":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(8472)/publications"},"_namespace":null},{"id":8473,"version":2,"created":1554917302000,"modified":1554917305000,"deprecated":false,"name":"Adhesion G-protein coupled receptor G2","accession":"Q8IZP9","gene":"ADGRG2","description":"Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.3461983071692267,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.431229,"patentCount":6961,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.913626987038768,"pubTatorScore":1.12215579398197,"self":"https://pharos.nih.gov/idg/api/v1/targets(8473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8473)/publications"},"_namespace":null},{"id":8474,"version":3,"created":1554917306000,"modified":1555038332000,"deprecated":false,"name":"Actin-related protein 2/3 complex subunit 5","accession":"O15511","gene":"ARPC5","description":"Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0859915002040568,"antibodyCount":94,"monoclonalCount":46,"pubmedCount":null,"jensenScore":11.67095,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":45.78480391100476,"pubTatorScore":0.9208187886959324,"self":"https://pharos.nih.gov/idg/api/v1/targets(8474)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/properties"},"_links":{"count":1089,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8474)/publications"},"_namespace":null},{"id":8475,"version":3,"created":1554917310000,"modified":1555038333000,"deprecated":false,"name":"Circadian locomoter output cycles protein kaput","accession":"O15516","gene":"CLOCK","description":"Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-2.630131335784661,"antibodyCount":323,"monoclonalCount":82,"pubmedCount":null,"jensenScore":392.741826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":51.1304071041192,"pubTatorScore":2.6304543173634345,"self":"https://pharos.nih.gov/idg/api/v1/targets(8475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/properties"},"_links":{"count":1184,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/synonyms"},"_publications":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(8475)/publications"},"_namespace":null},{"id":8476,"version":3,"created":1554917316000,"modified":1555038335000,"deprecated":false,"name":"DNA-directed RNA polymerase II subunit RPB4","accession":"O15514","gene":"POLR2D","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5375567629528617,"antibodyCount":136,"monoclonalCount":10,"pubmedCount":null,"jensenScore":3.340078,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":37.13981415160953,"pubTatorScore":0.15126747095672716,"self":"https://pharos.nih.gov/idg/api/v1/targets(8476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8476)/publications"},"_namespace":null},{"id":8477,"version":4,"created":1554917319000,"modified":1555038337000,"deprecated":false,"name":"3-phosphoinositide-dependent protein kinase 1","accession":"O15530","gene":"PDPK1","description":"Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.120250016231711,"antibodyCount":608,"monoclonalCount":75,"pubmedCount":null,"jensenScore":204.919768,"patentCount":86102,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":55.90502628346062,"pubTatorScore":1.725204536593276,"self":"https://pharos.nih.gov/idg/api/v1/targets(8477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":791,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/properties"},"_links":{"count":1462,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/links"},"_synonyms":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/synonyms"},"_publications":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8477)/publications"},"_namespace":null},{"id":8478,"version":2,"created":1554917417000,"modified":1554917421000,"deprecated":false,"name":"Abl interactor 1","accession":"Q8IZP0","gene":"ABI1","description":"May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.999531215057872,"antibodyCount":264,"monoclonalCount":21,"pubmedCount":null,"jensenScore":104.145211,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.04616964727963,"pubTatorScore":1.9905819605584292,"self":"https://pharos.nih.gov/idg/api/v1/targets(8478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/properties"},"_links":{"count":1501,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/links"},"_synonyms":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8478)/publications"},"_namespace":null},{"id":8479,"version":2,"created":1554917423000,"modified":1554917423000,"deprecated":false,"name":"TBC1 domain family member 3","accession":"Q8IZP1","gene":"TBC1D3","description":"Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.010318771372505,"pubTatorScore":0.9558480201291164,"self":"https://pharos.nih.gov/idg/api/v1/targets(8479)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8479)/publications"},"_namespace":null},{"id":8480,"version":2,"created":1554917424000,"modified":1554917424000,"deprecated":false,"name":"Putative protein FAM10A4","accession":"Q8IZP2","gene":"ST13P4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.7468435541413623,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":82.306432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.0816072578258,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8480)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/properties"},"_links":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8480)/publications"},"_namespace":null},{"id":8481,"version":3,"created":1554917424000,"modified":1554917650000,"deprecated":false,"name":"cAMP-specific 3',5'-cyclic phosphodiesterase 4B","accession":"Q07343","gene":"PDE4B","description":"Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.132219720643368,"antibodyCount":341,"monoclonalCount":41,"pubmedCount":null,"jensenScore":124.328433,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.77162071226137,"pubTatorScore":2.0786071963873187,"self":"https://pharos.nih.gov/idg/api/v1/targets(8481)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(8481)/properties"},"_links":{"count":1923,"href":"https://pharos.nih.gov/idg/api/v1/targets(8481)/links"},"_synonyms":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(8481)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8481)/publications"},"_namespace":null},{"id":8482,"version":2,"created":1554917653000,"modified":1554917654000,"deprecated":false,"name":"RING finger protein 113B","accession":"Q8IZP6","gene":"RNF113B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.21387982091017985,"antibodyCount":137,"monoclonalCount":42,"pubmedCount":null,"jensenScore":0.722223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.02066102938086,"pubTatorScore":-0.2041199826559248,"self":"https://pharos.nih.gov/idg/api/v1/targets(8482)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8482)/properties"},"_links":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(8482)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8482)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8482)/publications"},"_namespace":null},{"id":8483,"version":2,"created":1554917655000,"modified":1554917657000,"deprecated":false,"name":"Heparan-sulfate 6-O-sulfotransferase 3","accession":"Q8IZP7","gene":"HS6ST3","description":"6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5909218244858817,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.194925,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.776699815924474,"pubTatorScore":0.6865223190337184,"self":"https://pharos.nih.gov/idg/api/v1/targets(8483)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(8483)/properties"},"_links":{"count":679,"href":"https://pharos.nih.gov/idg/api/v1/targets(8483)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8483)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8483)/publications"},"_namespace":null},{"id":8484,"version":3,"created":1554917658000,"modified":1555038340000,"deprecated":false,"name":"25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial","accession":"O15528","gene":"CYP27B1","description":"Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.7062795484925775,"antibodyCount":68,"monoclonalCount":1,"pubmedCount":null,"jensenScore":492.946838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":43.442513897077625,"pubTatorScore":2.5764656155261707,"self":"https://pharos.nih.gov/idg/api/v1/targets(8484)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(8484)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(8484)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8484)/synonyms"},"_publications":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8484)/publications"},"_namespace":null},{"id":8485,"version":2,"created":1554917665000,"modified":1554917666000,"deprecated":false,"name":"G-protein coupled receptor 42","accession":"O15529","gene":"GPR42","description":"Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.384615,"patentCount":1409,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.340130637667705,"pubTatorScore":0.06694691371473312,"self":"https://pharos.nih.gov/idg/api/v1/targets(8485)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8485)/properties"},"_links":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(8485)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8485)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8485)/publications"},"_namespace":null},{"id":8486,"version":2,"created":1554917666000,"modified":1554917667000,"deprecated":false,"name":"Homeobox protein Nkx-2.8","accession":"O15522","gene":"NKX2-8","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0100033424045936,"antibodyCount":145,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.884659,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.500334708540315,"pubTatorScore":0.9544692966995878,"self":"https://pharos.nih.gov/idg/api/v1/targets(8486)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(8486)/properties"},"_links":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(8486)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8486)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8486)/publications"},"_namespace":null},{"id":8487,"version":2,"created":1554917667000,"modified":1554917671000,"deprecated":false,"name":"ATP-dependent RNA helicase DDX3Y","accession":"O15523","gene":"DDX3Y","description":"Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8127887537178233,"antibodyCount":167,"monoclonalCount":20,"pubmedCount":null,"jensenScore":65.122688,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.181030485302546,"pubTatorScore":1.6074118060826676,"self":"https://pharos.nih.gov/idg/api/v1/targets(8487)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(8487)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(8487)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8487)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8487)/publications"},"_namespace":null},{"id":8488,"version":2,"created":1554917672000,"modified":1554917675000,"deprecated":false,"name":"CST complex subunit CTC1","accession":"Q2NKJ3","gene":"CTC1","description":"Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7481773956074111,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":54.20482,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.877359089050714,"pubTatorScore":1.5074931653106827,"self":"https://pharos.nih.gov/idg/api/v1/targets(8488)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(8488)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(8488)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8488)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8488)/publications"},"_namespace":null},{"id":8489,"version":3,"created":1554917676000,"modified":1555038342000,"deprecated":false,"name":"Fibroblast growth factor 10","accession":"O15520","gene":"FGF10","description":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5516585788914212,"antibodyCount":320,"monoclonalCount":33,"pubmedCount":null,"jensenScore":363.008643,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":35.3559221737308,"pubTatorScore":2.262958225089715,"self":"https://pharos.nih.gov/idg/api/v1/targets(8489)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":519,"href":"https://pharos.nih.gov/idg/api/v1/targets(8489)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(8489)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8489)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8489)/publications"},"_namespace":null},{"id":8490,"version":2,"created":1554917681000,"modified":1554917686000,"deprecated":false,"name":"N-glycosylase/DNA lyase","accession":"O15527","gene":"OGG1","description":"DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.2614651885663153,"antibodyCount":293,"monoclonalCount":50,"pubmedCount":null,"jensenScore":1834.892324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.14881016341657,"pubTatorScore":3.004344431197581,"self":"https://pharos.nih.gov/idg/api/v1/targets(8490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(8490)/properties"},"_links":{"count":1436,"href":"https://pharos.nih.gov/idg/api/v1/targets(8490)/links"},"_synonyms":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(8490)/synonyms"},"_publications":{"count":535,"href":"https://pharos.nih.gov/idg/api/v1/targets(8490)/publications"},"_namespace":null},{"id":8491,"version":3,"created":1554917688000,"modified":1555038343000,"deprecated":false,"name":"Suppressor of cytokine signaling 1","accession":"O15524","gene":"SOCS1","description":"SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0585084439981047,"antibodyCount":469,"monoclonalCount":25,"pubmedCount":null,"jensenScore":1163.751426,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.68028139200099,"pubTatorScore":2.8987260457907844,"self":"https://pharos.nih.gov/idg/api/v1/targets(8491)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":754,"href":"https://pharos.nih.gov/idg/api/v1/targets(8491)/properties"},"_links":{"count":1226,"href":"https://pharos.nih.gov/idg/api/v1/targets(8491)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8491)/synonyms"},"_publications":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(8491)/publications"},"_namespace":null},{"id":8492,"version":3,"created":1554917695000,"modified":1555038346000,"deprecated":false,"name":"Transcription factor MafG","accession":"O15525","gene":"MAFG","description":"Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7797341818275163,"antibodyCount":107,"monoclonalCount":7,"pubmedCount":null,"jensenScore":57.973397,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.143406273050864,"pubTatorScore":1.533674871261985,"self":"https://pharos.nih.gov/idg/api/v1/targets(8492)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(8492)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(8492)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8492)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8492)/publications"},"_namespace":null},{"id":8493,"version":2,"created":1554917699000,"modified":1554917701000,"deprecated":false,"name":"Chemokine XC receptor 1","accession":"P46094","gene":"XCR1","description":"Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.8085467497906307,"antibodyCount":206,"monoclonalCount":30,"pubmedCount":null,"jensenScore":55.691124,"patentCount":8887,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.616472005564425,"pubTatorScore":1.4454128380550173,"self":"https://pharos.nih.gov/idg/api/v1/targets(8493)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8493)/properties"},"_links":{"count":628,"href":"https://pharos.nih.gov/idg/api/v1/targets(8493)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8493)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8493)/publications"},"_namespace":null},{"id":8494,"version":2,"created":1554917701000,"modified":1554917717000,"deprecated":false,"name":"G-protein coupled receptor 4","accession":"P46093","gene":"GPR4","description":"Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.6231069259455932,"antibodyCount":119,"monoclonalCount":2,"pubmedCount":null,"jensenScore":46.90889,"patentCount":8390,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.094163791895113,"pubTatorScore":1.4899361597691965,"self":"https://pharos.nih.gov/idg/api/v1/targets(8494)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(8494)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(8494)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8494)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8494)/publications"},"_namespace":null},{"id":8495,"version":3,"created":1554917718000,"modified":1555038347000,"deprecated":false,"name":"G-protein coupled receptor 6","accession":"P46095","gene":"GPR6","description":"Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.0692423958865278,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.454736,"patentCount":4528,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":21.918798421167377,"pubTatorScore":0.8717396165989697,"self":"https://pharos.nih.gov/idg/api/v1/targets(8495)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(8495)/properties"},"_links":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(8495)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8495)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8495)/publications"},"_namespace":null},{"id":8496,"version":2,"created":1554917720000,"modified":1554917723000,"deprecated":false,"name":"Fatty acid-binding protein, brain","accession":"O15540","gene":"FABP7","description":"B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1658680741436727,"antibodyCount":416,"monoclonalCount":110,"pubmedCount":null,"jensenScore":158.463233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.64229401003345,"pubTatorScore":1.9793526203830825,"self":"https://pharos.nih.gov/idg/api/v1/targets(8496)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(8496)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(8496)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8496)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8496)/publications"},"_namespace":null},{"id":8497,"version":4,"created":1554917724000,"modified":1555038352000,"deprecated":false,"name":"5-hydroxytryptamine receptor 3A","accession":"P46098","gene":"HTR3A","description":"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-3.3866127873337866,"antibodyCount":262,"monoclonalCount":5,"pubmedCount":null,"jensenScore":2426.699181,"patentCount":35350,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":97,"knowledgeAvailability":35.510319783639964,"pubTatorScore":2.4526124127526603,"self":"https://pharos.nih.gov/idg/api/v1/targets(8497)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(8497)/properties"},"_links":{"count":1183,"href":"https://pharos.nih.gov/idg/api/v1/targets(8497)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(8497)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8497)/publications"},"_namespace":null},{"id":8498,"version":3,"created":1554917850000,"modified":1555038354000,"deprecated":false,"name":"RING finger protein 113A","accession":"O15541","gene":"RNF113A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8073094675436709,"antibodyCount":76,"monoclonalCount":7,"pubmedCount":null,"jensenScore":8.00469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":28.046001506177245,"pubTatorScore":0.21085336531489318,"self":"https://pharos.nih.gov/idg/api/v1/targets(8498)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(8498)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(8498)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8498)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8498)/publications"},"_namespace":null},{"id":8499,"version":2,"created":1554917854000,"modified":1554917857000,"deprecated":false,"name":"C-C chemokine receptor type 10","accession":"P46092","gene":"CCR10","description":"Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.2187980033232715,"antibodyCount":266,"monoclonalCount":61,"pubmedCount":null,"jensenScore":15.579931,"patentCount":13640,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.45868861937972,"pubTatorScore":1.698879739877085,"self":"https://pharos.nih.gov/idg/api/v1/targets(8499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(8499)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(8499)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8499)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8499)/publications"},"_namespace":null},{"id":8500,"version":2,"created":1554917858000,"modified":1554917860000,"deprecated":false,"name":"G-protein coupled receptor 1","accession":"P46091","gene":"GPR1","description":"Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.6382536596552242,"antibodyCount":144,"monoclonalCount":5,"pubmedCount":null,"jensenScore":37.735973,"patentCount":6753,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.108727869500683,"pubTatorScore":1.340358238993818,"self":"https://pharos.nih.gov/idg/api/v1/targets(8500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(8500)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(8500)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8500)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8500)/publications"},"_namespace":null},{"id":8501,"version":2,"created":1554917861000,"modified":1554917861000,"deprecated":false,"name":"Beta-defensin 107","accession":"Q8IZN7","gene":"DEFB107B","description":"Has antibacterial activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5792844388467294,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.57821,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.923753366319241,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8501)/properties"},"_links":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8501)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8501)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8501)/publications"},"_namespace":null},{"id":8502,"version":2,"created":1554917861000,"modified":1554917864000,"deprecated":false,"name":"Rab-like protein 6","accession":"Q3YEC7","gene":"RABL6","description":"May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8426785581941807,"antibodyCount":83,"monoclonalCount":8,"pubmedCount":null,"jensenScore":6.910247,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.25000333222221,"pubTatorScore":1.0969099782644964,"self":"https://pharos.nih.gov/idg/api/v1/targets(8502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(8502)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(8502)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8502)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8502)/publications"},"_namespace":null},{"id":8503,"version":3,"created":1554917865000,"modified":1555038355000,"deprecated":false,"name":"Regulator of G-protein signaling 5","accession":"O15539","gene":"RGS5","description":"Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6803098586600962,"antibodyCount":257,"monoclonalCount":42,"pubmedCount":null,"jensenScore":49.279458,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.72806094762439,"pubTatorScore":1.7229921088592473,"self":"https://pharos.nih.gov/idg/api/v1/targets(8503)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(8503)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(8503)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8503)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8503)/publications"},"_namespace":null},{"id":8504,"version":2,"created":1554917871000,"modified":1554917875000,"deprecated":false,"name":"Tapasin","accession":"O15533","gene":"TAPBP","description":"Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.606614348409527,"antibodyCount":148,"monoclonalCount":1,"pubmedCount":null,"jensenScore":398.095104,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.24244304058467,"pubTatorScore":1.8249536158872877,"self":"https://pharos.nih.gov/idg/api/v1/targets(8504)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":474,"href":"https://pharos.nih.gov/idg/api/v1/targets(8504)/properties"},"_links":{"count":1246,"href":"https://pharos.nih.gov/idg/api/v1/targets(8504)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(8504)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8504)/publications"},"_namespace":null},{"id":8505,"version":3,"created":1554917877000,"modified":1555038357000,"deprecated":false,"name":"Period circadian protein homolog 1","accession":"O15534","gene":"PER1","description":"Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.864493348308136,"antibodyCount":178,"monoclonalCount":13,"pubmedCount":null,"jensenScore":71.376263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":47.152705171396704,"pubTatorScore":3.214249644397373,"self":"https://pharos.nih.gov/idg/api/v1/targets(8505)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/synonyms"},"_publications":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8505)/publications"},"_namespace":null},{"id":8506,"version":2,"created":1554917881000,"modified":1554917884000,"deprecated":false,"name":"Retinoschisin","accession":"O15537","gene":"RS1","description":"Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1082830635994663,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":131.269091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.10124985755508,"pubTatorScore":2.609422034806526,"self":"https://pharos.nih.gov/idg/api/v1/targets(8506)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/properties"},"_links":{"count":702,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8506)/publications"},"_namespace":null},{"id":8507,"version":2,"created":1554917884000,"modified":1554917887000,"deprecated":false,"name":"Zinc finger and SCAN domain-containing protein 9","accession":"O15535","gene":"ZSCAN9","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.06214790530119616,"antibodyCount":119,"monoclonalCount":12,"pubmedCount":null,"jensenScore":0.845238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.335064004754642,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8507)/publications"},"_namespace":null},{"id":8508,"version":2,"created":1554917887000,"modified":1554917890000,"deprecated":false,"name":"Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase","accession":"P46087","gene":"NOP2","description":"Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.500266604268691,"antibodyCount":69,"monoclonalCount":2,"pubmedCount":null,"jensenScore":29.532846,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.82066748503302,"pubTatorScore":1.49934928732378,"self":"https://pharos.nih.gov/idg/api/v1/targets(8508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/properties"},"_links":{"count":1048,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(8508)/publications"},"_namespace":null},{"id":8509,"version":2,"created":1554917891000,"modified":1554917894000,"deprecated":false,"name":"Claudin-3","accession":"O15551","gene":"CLDN3","description":"Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.376805516887729,"antibodyCount":358,"monoclonalCount":48,"pubmedCount":null,"jensenScore":227.318425,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.71555335613557,"pubTatorScore":2.0379002141423874,"self":"https://pharos.nih.gov/idg/api/v1/targets(8509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8509)/publications"},"_namespace":null},{"id":8510,"version":2,"created":1554917895000,"modified":1554917895000,"deprecated":false,"name":"Olfactory receptor 2AJ1","accession":"Q8NGZ0","gene":"OR2AJ1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":89,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2723321439053135,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/properties"},"_links":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8510)/publications"},"_namespace":null},{"id":8511,"version":2,"created":1554917896000,"modified":1554917900000,"deprecated":false,"name":"Free fatty acid receptor 2","accession":"O15552","gene":"FFAR2","description":"G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.126173887682798,"antibodyCount":221,"monoclonalCount":3,"pubmedCount":null,"jensenScore":144.582927,"patentCount":9122,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.079185205442453,"pubTatorScore":1.7815416707324592,"self":"https://pharos.nih.gov/idg/api/v1/targets(8511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8511)/publications"},"_namespace":null},{"id":8512,"version":3,"created":1554917901000,"modified":1555038358000,"deprecated":false,"name":"G-protein coupled receptor 3","accession":"P46089","gene":"GPR3","description":"Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.514291347073382,"antibodyCount":247,"monoclonalCount":34,"pubmedCount":null,"jensenScore":37.508068,"patentCount":7986,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.948313685560947,"pubTatorScore":1.7975225152731011,"self":"https://pharos.nih.gov/idg/api/v1/targets(8512)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8512)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(8512)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8512)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8512)/publications"},"_namespace":null},{"id":8513,"version":2,"created":1554917904000,"modified":1554917909000,"deprecated":false,"name":"Lysine-specific demethylase 6A","accession":"O15550","gene":"KDM6A","description":"Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.2799879680715307,"antibodyCount":119,"monoclonalCount":39,"pubmedCount":null,"jensenScore":176.833192,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.58066279826927,"pubTatorScore":2.0048733594308508,"self":"https://pharos.nih.gov/idg/api/v1/targets(8513)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(8513)/properties"},"_links":{"count":1213,"href":"https://pharos.nih.gov/idg/api/v1/targets(8513)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8513)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8513)/publications"},"_namespace":null},{"id":8514,"version":2,"created":1554917910000,"modified":1554917911000,"deprecated":false,"name":"Olfactory receptor 2G3","accession":"Q8NGZ4","gene":"OR2G3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.111111,"patentCount":126,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.601198142824412,"pubTatorScore":1.453573122756146,"self":"https://pharos.nih.gov/idg/api/v1/targets(8514)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8514)/properties"},"_links":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8514)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8514)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8514)/publications"},"_namespace":null},{"id":8515,"version":3,"created":1554917911000,"modified":1555038359000,"deprecated":false,"name":"C-X-C motif chemokine 9","accession":"Q07325","gene":"CXCL9","description":"Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.979535128924394,"antibodyCount":413,"monoclonalCount":124,"pubmedCount":null,"jensenScore":923.754997,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.79617906206623,"pubTatorScore":2.596701843618172,"self":"https://pharos.nih.gov/idg/api/v1/targets(8515)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(8515)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(8515)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8515)/synonyms"},"_publications":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8515)/publications"},"_namespace":null},{"id":8516,"version":3,"created":1554917917000,"modified":1555038361000,"deprecated":false,"name":"Phosphatidylinositol-glycan biosynthesis class F protein","accession":"Q07326","gene":"PIGF","description":"Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.899579479424719,"antibodyCount":71,"monoclonalCount":21,"pubmedCount":null,"jensenScore":69.164475,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.714933107876206,"pubTatorScore":1.7293550921338081,"self":"https://pharos.nih.gov/idg/api/v1/targets(8516)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(8516)/properties"},"_links":{"count":841,"href":"https://pharos.nih.gov/idg/api/v1/targets(8516)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8516)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8516)/publications"},"_namespace":null},{"id":8517,"version":2,"created":1554917920000,"modified":1554917921000,"deprecated":false,"name":"Olfactory receptor 2G2","accession":"Q8NGZ5","gene":"OR2G2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":34,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":141,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.701636033796051,"pubTatorScore":1.436692576478957,"self":"https://pharos.nih.gov/idg/api/v1/targets(8517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8517)/properties"},"_links":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8517)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8517)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8517)/publications"},"_namespace":null},{"id":8518,"version":2,"created":1554917921000,"modified":1554917922000,"deprecated":false,"name":"F-box/WD repeat-containing protein 10","accession":"Q5XX13","gene":"FBXW10","description":"Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8760940592904999,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.924242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.312068697126243,"pubTatorScore":0.3889387736524194,"self":"https://pharos.nih.gov/idg/api/v1/targets(8518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(8518)/properties"},"_links":{"count":727,"href":"https://pharos.nih.gov/idg/api/v1/targets(8518)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8518)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8518)/publications"},"_namespace":null},{"id":8519,"version":2,"created":1554917923000,"modified":1554917923000,"deprecated":false,"name":"Olfactory receptor 14K1","accession":"Q8NGZ2","gene":"OR14K1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":94,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.406107047935745,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8519)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8519)/properties"},"_links":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8519)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8519)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8519)/publications"},"_namespace":null},{"id":8520,"version":2,"created":1554917924000,"modified":1554917924000,"deprecated":false,"name":"Olfactory receptor 13G1","accession":"Q8NGZ3","gene":"OR13G1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.026102801478468864,"antibodyCount":41,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.755357,"patentCount":246,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.640953575791494,"pubTatorScore":1.343955362041849,"self":"https://pharos.nih.gov/idg/api/v1/targets(8520)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8520)/properties"},"_links":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8520)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8520)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8520)/publications"},"_namespace":null},{"id":8521,"version":2,"created":1554917924000,"modified":1554917927000,"deprecated":false,"name":"Probable palmitoyltransferase ZDHHC14","accession":"Q8IZN3","gene":"ZDHHC14","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.8061799739838872,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.278171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.647150578960904,"pubTatorScore":0.7269987007928563,"self":"https://pharos.nih.gov/idg/api/v1/targets(8521)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8521)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(8521)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8521)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8521)/publications"},"_namespace":null},{"id":8522,"version":3,"created":1554917927000,"modified":1555038363000,"deprecated":false,"name":"Olfactory receptor 2T10","accession":"Q8NGZ9","gene":"OR2T10","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":30,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":102,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":7.419522924313755,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8522)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8522)/properties"},"_links":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8522)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8522)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8522)/publications"},"_namespace":null},{"id":8523,"version":2,"created":1554917928000,"modified":1554917929000,"deprecated":false,"name":"Olfactory receptor 6F1","accession":"Q8NGZ6","gene":"OR6F1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":271,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.103197026929063,"pubTatorScore":1.5956798873448255,"self":"https://pharos.nih.gov/idg/api/v1/targets(8523)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8523)/properties"},"_links":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8523)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8523)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8523)/publications"},"_namespace":null},{"id":8524,"version":2,"created":1554917929000,"modified":1554917929000,"deprecated":false,"name":"Olfactory receptor 2L8","accession":"Q8NGY9","gene":"OR2L8","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.071429,"patentCount":236,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.4772997907088445,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(8524)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8524)/properties"},"_links":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8524)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8524)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8524)/publications"},"_namespace":null},{"id":8525,"version":2,"created":1554917929000,"modified":1554917932000,"deprecated":false,"name":"Zinc finger protein 654","accession":"Q8IZM8","gene":"ZNF654","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5243331691671487,"antibodyCount":93,"monoclonalCount":5,"pubmedCount":null,"jensenScore":271.320932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.039261677707824,"pubTatorScore":-1.0791829832290267,"self":"https://pharos.nih.gov/idg/api/v1/targets(8525)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(8525)/properties"},"_links":{"count":831,"href":"https://pharos.nih.gov/idg/api/v1/targets(8525)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8525)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8525)/publications"},"_namespace":null},{"id":8526,"version":3,"created":1554917932000,"modified":1555038363000,"deprecated":false,"name":"Probable sodium-coupled neutral amino acid transporter 6","accession":"Q8IZM9","gene":"SLC38A6","description":"Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.24259466282710168,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.623611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.41117150503415,"pubTatorScore":0.10266245618515422,"self":"https://pharos.nih.gov/idg/api/v1/targets(8526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(8526)/properties"},"_links":{"count":861,"href":"https://pharos.nih.gov/idg/api/v1/targets(8526)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8526)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8526)/publications"},"_namespace":null},{"id":8527,"version":3,"created":1554917936000,"modified":1555038365000,"deprecated":false,"name":"Sperm-associated antigen 11B","accession":"Q08648","gene":"SPAG11B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.81079331957608,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.934725,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":18.380191767408412,"pubTatorScore":1.1822005626895924,"self":"https://pharos.nih.gov/idg/api/v1/targets(8527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8527)/properties"},"_links":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8527)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8527)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8527)/publications"},"_namespace":null},{"id":8528,"version":2,"created":1554917936000,"modified":1554917937000,"deprecated":false,"name":"Protein GR6","accession":"O15544","gene":"LINC01565","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.551760281345718,"pubTatorScore":1.027446609764698,"self":"https://pharos.nih.gov/idg/api/v1/targets(8528)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8528)/properties"},"_links":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8528)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8528)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8528)/publications"},"_namespace":null},{"id":8529,"version":3,"created":1554917937000,"modified":1555038365000,"deprecated":false,"name":"P2X purinoceptor 6","accession":"O15547","gene":"P2RX6","description":"Receptor for ATP that acts as a ligand-gated ion channel.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.4630745821823907,"antibodyCount":147,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.166226,"patentCount":15807,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.763866049283845,"pubTatorScore":1.263545366122352,"self":"https://pharos.nih.gov/idg/api/v1/targets(8529)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(8529)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(8529)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8529)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8529)/publications"},"_namespace":null},{"id":8530,"version":2,"created":1554917940000,"modified":1554917940000,"deprecated":false,"name":"Olfactory receptor 2V1","accession":"Q8NHB1","gene":"OR2V1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":92,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.985291858481806,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8530)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8530)/properties"},"_links":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8530)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8530)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8530)/publications"},"_namespace":null},{"id":8531,"version":3,"created":1554917940000,"modified":1555038367000,"deprecated":false,"name":"Protein FAM9B","accession":"Q8IZU0","gene":"FAM9B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.10833947435454379,"antibodyCount":24,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.819624,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":12.602028466682933,"pubTatorScore":0.3521825181113625,"self":"https://pharos.nih.gov/idg/api/v1/targets(8531)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(8531)/properties"},"_links":{"count":514,"href":"https://pharos.nih.gov/idg/api/v1/targets(8531)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8531)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8531)/publications"},"_namespace":null},{"id":8532,"version":2,"created":1554917943000,"modified":1554917943000,"deprecated":false,"name":"Olfactory receptor 5K1","accession":"Q8NHB7","gene":"OR5K1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":640,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.291977807483843,"pubTatorScore":1.722770975102192,"self":"https://pharos.nih.gov/idg/api/v1/targets(8532)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8532)/properties"},"_links":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8532)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8532)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8532)/publications"},"_namespace":null},{"id":8533,"version":3,"created":1554917943000,"modified":1555038367000,"deprecated":false,"name":"Protein FAM9A","accession":"Q8IZU1","gene":"FAM9A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.10616473580003284,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.4,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":11.090011926227334,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8533)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8533)/properties"},"_links":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(8533)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8533)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8533)/publications"},"_namespace":null},{"id":8534,"version":2,"created":1554917944000,"modified":1554917947000,"deprecated":false,"name":"WD repeat-containing protein 17","accession":"Q8IZU2","gene":"WDR17","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.052632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.90354977474073,"pubTatorScore":0.3832166320459405,"self":"https://pharos.nih.gov/idg/api/v1/targets(8534)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(8534)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(8534)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8534)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8534)/publications"},"_namespace":null},{"id":8535,"version":2,"created":1554917948000,"modified":1554917949000,"deprecated":false,"name":"Olfactory receptor 5K2","accession":"Q8NHB8","gene":"OR5K2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":114,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.233087610620158,"pubTatorScore":1.6947513780315588,"self":"https://pharos.nih.gov/idg/api/v1/targets(8535)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(8535)/properties"},"_links":{"count":616,"href":"https://pharos.nih.gov/idg/api/v1/targets(8535)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8535)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8535)/publications"},"_namespace":null},{"id":8536,"version":3,"created":1554917950000,"modified":1555038368000,"deprecated":false,"name":"Synaptonemal complex protein 3","accession":"Q8IZU3","gene":"SYCP3","description":"Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2084525023151755,"antibodyCount":255,"monoclonalCount":73,"pubmedCount":null,"jensenScore":154.377674,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.830980857700474,"pubTatorScore":1.9880420261946272,"self":"https://pharos.nih.gov/idg/api/v1/targets(8536)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(8536)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(8536)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8536)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8536)/publications"},"_namespace":null},{"id":8537,"version":2,"created":1554917954000,"modified":1554917956000,"deprecated":false,"name":"Dermatan-sulfate epimerase-like protein","accession":"Q8IZU8","gene":"DSEL","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.8671738233010459,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.989579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.56273087270918,"pubTatorScore":0.5723736199733959,"self":"https://pharos.nih.gov/idg/api/v1/targets(8537)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8537)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(8537)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8537)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8537)/publications"},"_namespace":null},{"id":8538,"version":2,"created":1554917957000,"modified":1554917960000,"deprecated":false,"name":"Kin of IRRE-like protein 3","accession":"Q8IZU9","gene":"KIRREL3","description":"Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.476924086359119,"antibodyCount":105,"monoclonalCount":26,"pubmedCount":null,"jensenScore":31.869232,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.753413561026505,"pubTatorScore":0.7510129015410957,"self":"https://pharos.nih.gov/idg/api/v1/targets(8538)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(8538)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(8538)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8538)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8538)/publications"},"_namespace":null},{"id":8539,"version":2,"created":1554917960000,"modified":1554917961000,"deprecated":false,"name":"Keratin-associated protein 10-6","accession":"P60371","gene":"KRTAP10-6","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.890583982986428,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8539)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8539)/properties"},"_links":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8539)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8539)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8539)/publications"},"_namespace":null},{"id":8540,"version":2,"created":1554917961000,"modified":1554917962000,"deprecated":false,"name":"Keratin-associated protein 10-5","accession":"P60370","gene":"KRTAP10-5","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.948463978368394,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8540)/properties"},"_links":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8540)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8540)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8540)/publications"},"_namespace":null},{"id":8541,"version":3,"created":1554917962000,"modified":1555038369000,"deprecated":false,"name":"Serine protease inhibitor Kazal-type 7","accession":"P58062","gene":"SPINK7","description":"Probable serine protease inhibitor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6262955808944988,"antibodyCount":60,"monoclonalCount":2,"pubmedCount":null,"jensenScore":43.878208,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":14.152015724932342,"pubTatorScore":1.699207758903048,"self":"https://pharos.nih.gov/idg/api/v1/targets(8541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(8541)/properties"},"_links":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(8541)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8541)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8541)/publications"},"_namespace":null},{"id":8542,"version":2,"created":1554917964000,"modified":1554917966000,"deprecated":false,"name":"Keratin-associated protein 10-4","accession":"P60372","gene":"KRTAP10-4","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.595320482083148,"pubTatorScore":-0.01046564552918342,"self":"https://pharos.nih.gov/idg/api/v1/targets(8542)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8542)/properties"},"_links":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8542)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8542)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8542)/publications"},"_namespace":null},{"id":8543,"version":2,"created":1554917966000,"modified":1554917968000,"deprecated":false,"name":"Synaptotagmin-like protein 3","accession":"Q4VX76","gene":"SYTL3","description":"May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0266871024558542,"antibodyCount":84,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.360008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.419450701125267,"pubTatorScore":0.4598946519152871,"self":"https://pharos.nih.gov/idg/api/v1/targets(8543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(8543)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(8543)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8543)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8543)/publications"},"_namespace":null},{"id":8544,"version":2,"created":1554917969000,"modified":1554917969000,"deprecated":false,"name":"Putative olfactory receptor 2W6","accession":"Q8NHA6","gene":"OR2W6P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.214877554122326,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(8544)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8544)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(8544)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8544)/publications"},"_namespace":null},{"id":8545,"version":2,"created":1554917969000,"modified":1554917971000,"deprecated":false,"name":"Olfactory receptor 2AE1","accession":"Q8NHA4","gene":"OR2AE1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":103,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.806842155132125,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8545)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8545)/properties"},"_links":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(8545)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8545)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8545)/publications"},"_namespace":null},{"id":8546,"version":2,"created":1554917971000,"modified":1554917975000,"deprecated":false,"name":"Abnormal spindle-like microcephaly-associated protein","accession":"Q8IZT6","gene":"ASPM","description":"Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5245261046115137,"antibodyCount":40,"monoclonalCount":2,"pubmedCount":null,"jensenScore":32.710787,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.87243866794375,"pubTatorScore":2.017077100614789,"self":"https://pharos.nih.gov/idg/api/v1/targets(8546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(8546)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(8546)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8546)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8546)/publications"},"_namespace":null},{"id":8547,"version":2,"created":1554917976000,"modified":1554917977000,"deprecated":false,"name":"Olfactory receptor 1F12","accession":"Q8NHA8","gene":"OR1F12","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.4216600718099296,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8547)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8547)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8547)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8547)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8547)/publications"},"_namespace":null},{"id":8548,"version":2,"created":1554917977000,"modified":1554917979000,"deprecated":false,"name":"Heparan sulfate glucosamine 3-O-sulfotransferase 5","accession":"Q8IZT8","gene":"HS3ST5","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5604087173764164,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.774432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.793343192518545,"pubTatorScore":0.8512583487190752,"self":"https://pharos.nih.gov/idg/api/v1/targets(8548)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8548)/properties"},"_links":{"count":708,"href":"https://pharos.nih.gov/idg/api/v1/targets(8548)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8548)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8548)/publications"},"_namespace":null},{"id":8549,"version":3,"created":1554917980000,"modified":1555038371000,"deprecated":false,"name":"Protein FAM9C","accession":"Q8IZT9","gene":"FAM9C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.15490196042003768,"antibodyCount":8,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.888889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":56,"knowledgeAvailability":11.010186710134034,"pubTatorScore":0.28254643891099157,"self":"https://pharos.nih.gov/idg/api/v1/targets(8549)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(8549)/properties"},"_links":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(8549)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8549)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8549)/publications"},"_namespace":null},{"id":8550,"version":2,"created":1554917981000,"modified":1554917985000,"deprecated":false,"name":"Shugoshin 1","accession":"Q5FBB7","gene":"SGO1","description":"Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4422402348682164,"antibodyCount":148,"monoclonalCount":10,"pubmedCount":null,"jensenScore":279.811752,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.7341518717730406,"self":"https://pharos.nih.gov/idg/api/v1/targets(8550)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(8550)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(8550)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(8550)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8550)/publications"},"_namespace":null},{"id":8551,"version":2,"created":1554917986000,"modified":1554917989000,"deprecated":false,"name":"Testican-1","accession":"Q08629","gene":"SPOCK1","description":"May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9946517243076503,"antibodyCount":92,"monoclonalCount":5,"pubmedCount":null,"jensenScore":104.640579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.30988024551337,"pubTatorScore":1.5286197366497056,"self":"https://pharos.nih.gov/idg/api/v1/targets(8551)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(8551)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(8551)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8551)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8551)/publications"},"_namespace":null},{"id":8552,"version":3,"created":1554917990000,"modified":1555038372000,"deprecated":false,"name":"Nicotinate phosphoribosyltransferase","accession":"Q6XQN6","gene":"NAPRT","description":"Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.262352222988578,"antibodyCount":103,"monoclonalCount":17,"pubmedCount":null,"jensenScore":18.21337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.39367364796274,"pubTatorScore":1.3781959161367154,"self":"https://pharos.nih.gov/idg/api/v1/targets(8552)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(8552)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(8552)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8552)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8552)/publications"},"_namespace":null},{"id":8553,"version":2,"created":1554917995000,"modified":1554917995000,"deprecated":false,"name":"Putative uncharacterized protein C6orf99","accession":"Q4VX62","gene":"C6orf99","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8553)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8553)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8553)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8553)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8553)/publications"},"_namespace":null},{"id":8554,"version":2,"created":1554917995000,"modified":1554917998000,"deprecated":false,"name":"Lysophospholipid acyltransferase 2","accession":"Q6ZWT7","gene":"MBOAT2","description":"Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3984166912268967,"antibodyCount":67,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.859868,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.68905914688207,"pubTatorScore":1.2969017066688342,"self":"https://pharos.nih.gov/idg/api/v1/targets(8554)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(8554)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(8554)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8554)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8554)/publications"},"_namespace":null},{"id":8555,"version":2,"created":1554917999000,"modified":1554918001000,"deprecated":false,"name":"Pseudouridine-5'-phosphatase","accession":"Q08623","gene":"PUDP","description":"Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4168253566928068,"antibodyCount":79,"monoclonalCount":41,"pubmedCount":null,"jensenScore":1.930556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.711947749059545,"self":"https://pharos.nih.gov/idg/api/v1/targets(8555)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(8555)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(8555)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8555)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8555)/publications"},"_namespace":null},{"id":8556,"version":3,"created":1554918002000,"modified":1555038373000,"deprecated":false,"name":"Orofacial cleft 1 candidate gene 1 protein","accession":"Q8IZS5","gene":"OFCC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3284310003243236,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.285965,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":14.83698441170933,"pubTatorScore":0.3364423216930644,"self":"https://pharos.nih.gov/idg/api/v1/targets(8556)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(8556)/properties"},"_links":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(8556)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8556)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8556)/publications"},"_namespace":null},{"id":8557,"version":2,"created":1554918003000,"modified":1554918005000,"deprecated":false,"name":"Tctex1 domain-containing protein 3","accession":"Q8IZS6","gene":"TCTE3","description":"May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6999213687891954,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.528788,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.50904382401144,"pubTatorScore":0.6729123660494298,"self":"https://pharos.nih.gov/idg/api/v1/targets(8557)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(8557)/properties"},"_links":{"count":751,"href":"https://pharos.nih.gov/idg/api/v1/targets(8557)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8557)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8557)/publications"},"_namespace":null},{"id":8558,"version":2,"created":1554918006000,"modified":1554918007000,"deprecated":false,"name":"C-type lectin-like domain family 1","accession":"Q8IZS7","gene":"CLECL1","description":"May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.11539342000495299,"antibodyCount":44,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.629798,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.070309964761243,"pubTatorScore":0.6258267132857112,"self":"https://pharos.nih.gov/idg/api/v1/targets(8558)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(8558)/properties"},"_links":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(8558)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8558)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8558)/publications"},"_namespace":null},{"id":8559,"version":3,"created":1554918008000,"modified":1555038375000,"deprecated":false,"name":"Voltage-dependent calcium channel subunit alpha-2/delta-3","accession":"Q8IZS8","gene":"CACNA2D3","description":"The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.0440245948182014,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.014238,"patentCount":1727,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.14466739834084,"pubTatorScore":1.1572600368398491,"self":"https://pharos.nih.gov/idg/api/v1/targets(8559)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(8559)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(8559)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8559)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8559)/publications"},"_namespace":null},{"id":8560,"version":2,"created":1554918012000,"modified":1554918014000,"deprecated":false,"name":"39S ribosomal protein L51, mitochondrial","accession":"Q4U2R6","gene":"MRPL51","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.21559980189040656,"antibodyCount":106,"monoclonalCount":16,"pubmedCount":null,"jensenScore":1.59478,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.691564139105886,"pubTatorScore":-0.5070846332023055,"self":"https://pharos.nih.gov/idg/api/v1/targets(8560)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(8560)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(8560)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8560)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8560)/publications"},"_namespace":null},{"id":8561,"version":3,"created":1554918015000,"modified":1555038377000,"deprecated":false,"name":"Solute carrier family 22 member 6","accession":"Q4U2R8","gene":"SLC22A6","description":"Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.","idgFamily":"Transporter","idgTDL":"Tclin","novelty":-2.3261675089068423,"antibodyCount":200,"monoclonalCount":7,"pubmedCount":null,"jensenScore":211.247666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":27.477056516095512,"pubTatorScore":2.268280614722028,"self":"https://pharos.nih.gov/idg/api/v1/targets(8561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/properties"},"_links":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/links"},"_synonyms":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8561)/publications"},"_namespace":null},{"id":8562,"version":3,"created":1554918020000,"modified":1555038378000,"deprecated":false,"name":"Small G protein signaling modulator 1","accession":"Q2NKQ1","gene":"SGSM1","description":"Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.12674453561374707,"antibodyCount":65,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.618254,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":24.224739899367748,"pubTatorScore":0.06900986786367136,"self":"https://pharos.nih.gov/idg/api/v1/targets(8562)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(8562)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(8562)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8562)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8562)/publications"},"_namespace":null},{"id":8563,"version":3,"created":1554918024000,"modified":1555038379000,"deprecated":false,"name":"Beta-actin-like protein 2","accession":"Q562R1","gene":"ACTBL2","description":"Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7565093297877455,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.614123,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":19.093223216790292,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(8563)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(8563)/properties"},"_links":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(8563)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8563)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8563)/publications"},"_namespace":null},{"id":8564,"version":2,"created":1554918025000,"modified":1554918028000,"deprecated":false,"name":"CKLF-like MARVEL transmembrane domain-containing protein 4","accession":"Q8IZR5","gene":"CMTM4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6842467511344331,"antibodyCount":104,"monoclonalCount":50,"pubmedCount":null,"jensenScore":4.878035,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.39637209634257,"pubTatorScore":0.48192008987676016,"self":"https://pharos.nih.gov/idg/api/v1/targets(8564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(8564)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(8564)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8564)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8564)/publications"},"_namespace":null},{"id":8565,"version":2,"created":1554918029000,"modified":1554918029000,"deprecated":false,"name":"Immunoglobulin lambda constant 7","accession":"A0M8Q6","gene":"IGLC7","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.9621732590657062,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":230.691813,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.56265029831047,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/properties"},"_links":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8565)/publications"},"_namespace":null},{"id":8566,"version":2,"created":1554918029000,"modified":1554918032000,"deprecated":false,"name":"Nucleoporin-like protein 2","accession":"O15504","gene":"NUPL2","description":"Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0407341688428406,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.508688,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.558961697933334,"pubTatorScore":1.0043725401182955,"self":"https://pharos.nih.gov/idg/api/v1/targets(8566)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(8566)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(8566)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8566)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8566)/publications"},"_namespace":null},{"id":8567,"version":2,"created":1554918033000,"modified":1554918037000,"deprecated":false,"name":"Insulin-induced gene 1 protein","accession":"O15503","gene":"INSIG1","description":"Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.297271419239059,"antibodyCount":147,"monoclonalCount":0,"pubmedCount":null,"jensenScore":186.906528,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.970464542576096,"pubTatorScore":1.8978443491021757,"self":"https://pharos.nih.gov/idg/api/v1/targets(8567)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8567)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(8567)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8567)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8567)/publications"},"_namespace":null},{"id":8568,"version":3,"created":1554918038000,"modified":1555038380000,"deprecated":false,"name":"Protein-L-isoaspartate(D-aspartate) O-methyltransferase","accession":"P22061","gene":"PCMT1","description":"Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.823568676774579,"antibodyCount":154,"monoclonalCount":40,"pubmedCount":null,"jensenScore":67.515605,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":38.37821578730571,"pubTatorScore":1.8029177777382,"self":"https://pharos.nih.gov/idg/api/v1/targets(8568)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(8568)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(8568)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8568)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8568)/publications"},"_namespace":null},{"id":8569,"version":2,"created":1554918042000,"modified":1554918046000,"deprecated":false,"name":"40S ribosomal protein S3","accession":"P23396","gene":"RPS3","description":"Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1948867135615595,"antibodyCount":218,"monoclonalCount":39,"pubmedCount":null,"jensenScore":157.724453,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.38355145481775,"pubTatorScore":2.153739211276073,"self":"https://pharos.nih.gov/idg/api/v1/targets(8569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(8569)/properties"},"_links":{"count":1212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8569)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(8569)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8569)/publications"},"_namespace":null},{"id":8570,"version":2,"created":1554918048000,"modified":1554918050000,"deprecated":false,"name":"MRN complex-interacting protein","accession":"Q6NTE8","gene":"MRNIP","description":"Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.3010299956639812,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.8,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(8570)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(8570)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8570)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8570)/publications"},"_namespace":null},{"id":8571,"version":2,"created":1554918051000,"modified":1554918052000,"deprecated":false,"name":"Olfactory receptor 52J3","accession":"Q8NH60","gene":"OR52J3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.4259687328151493,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.277778,"patentCount":110,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.819152988866964,"pubTatorScore":-0.405765504109289,"self":"https://pharos.nih.gov/idg/api/v1/targets(8571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8571)/properties"},"_links":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8571)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8571)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8571)/publications"},"_namespace":null},{"id":8572,"version":2,"created":1554918053000,"modified":1554918053000,"deprecated":false,"name":"Olfactory receptor 51H1","accession":"Q8NH63","gene":"OR51H1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":77,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.162591938939931,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8572)/properties"},"_links":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8572)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8572)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8572)/publications"},"_namespace":null},{"id":8573,"version":2,"created":1554918053000,"modified":1554918053000,"deprecated":false,"name":"Olfactory receptor 51A7","accession":"Q8NH64","gene":"OR51A7","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":120,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.438371572964883,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8573)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8573)/properties"},"_links":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8573)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8573)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8573)/publications"},"_namespace":null},{"id":8574,"version":2,"created":1554918053000,"modified":1554918054000,"deprecated":false,"name":"Putative olfactory receptor 2I1","accession":"Q8NGU4","gene":"OR2I1P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.7713672749942806,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8574)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8574)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8574)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8574)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8574)/publications"},"_namespace":null},{"id":8575,"version":2,"created":1554918054000,"modified":1554918055000,"deprecated":false,"name":"Olfactory receptor 51F2","accession":"Q8NH61","gene":"OR51F2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":28,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":107,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.759224081589648,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8575)/properties"},"_links":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8575)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8575)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8575)/publications"},"_namespace":null},{"id":8576,"version":2,"created":1554918055000,"modified":1554918055000,"deprecated":false,"name":"Putative olfactory receptor 9A1","accession":"Q8NGU1","gene":"OR9A1P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.5630041342771264,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8576)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8576)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8576)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8576)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8576)/publications"},"_namespace":null},{"id":8577,"version":2,"created":1554918055000,"modified":1554918055000,"deprecated":false,"name":"Olfactory receptor 9A4","accession":"Q8NGU2","gene":"OR9A4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":123,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.179230342398569,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8577)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8577)/properties"},"_links":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8577)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8577)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8577)/publications"},"_namespace":null},{"id":8578,"version":3,"created":1554918055000,"modified":1555038382000,"deprecated":false,"name":"Olfactory receptor 52N5","accession":"Q8NH56","gene":"OR52N5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":169,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":8.108050908152059,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8578)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8578)/properties"},"_links":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8578)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8578)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8578)/publications"},"_namespace":null},{"id":8579,"version":2,"created":1554918056000,"modified":1554918056000,"deprecated":false,"name":"Putative olfactory receptor 52P1","accession":"Q8NH57","gene":"OR52P1P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.4216600718099296,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8579)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8579)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8579)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8579)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8579)/publications"},"_namespace":null},{"id":8580,"version":2,"created":1554918056000,"modified":1554918057000,"deprecated":false,"name":"Olfactory receptor 2A12","accession":"Q8NGT7","gene":"OR2A12","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":62,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":103,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.117335994424174,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8580)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8580)/properties"},"_links":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8580)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8580)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8580)/publications"},"_namespace":null},{"id":8581,"version":2,"created":1554918057000,"modified":1554918060000,"deprecated":false,"name":"5'-3' exoribonuclease 1","accession":"Q8IZH2","gene":"XRN1","description":"Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1348225629288398,"antibodyCount":51,"monoclonalCount":5,"pubmedCount":null,"jensenScore":125.310369,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.741503019795566,"pubTatorScore":1.584120212306742,"self":"https://pharos.nih.gov/idg/api/v1/targets(8581)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(8581)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(8581)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8581)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8581)/publications"},"_namespace":null},{"id":8582,"version":2,"created":1554918060000,"modified":1554918061000,"deprecated":false,"name":"Olfactory receptor 56A3","accession":"Q8NH54","gene":"OR56A3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":115,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.97695897329868,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8582)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8582)/properties"},"_links":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8582)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8582)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8582)/publications"},"_namespace":null},{"id":8583,"version":3,"created":1554918061000,"modified":1555038382000,"deprecated":false,"name":"Chymotrypsin-like elastase family member 3A","accession":"P09093","gene":"CELA3A","description":"Efficient protease with alanine specificity but only little elastolytic activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2973522844557763,"antibodyCount":127,"monoclonalCount":22,"pubmedCount":null,"jensenScore":18.619195,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":16.52891794345029,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8583)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(8583)/properties"},"_links":{"count":645,"href":"https://pharos.nih.gov/idg/api/v1/targets(8583)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8583)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8583)/publications"},"_namespace":null},{"id":8584,"version":4,"created":1554918064000,"modified":1555038385000,"deprecated":false,"name":"Growth factor receptor-bound protein 2","accession":"P62993","gene":"GRB2","description":"Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.0240400062957504,"antibodyCount":501,"monoclonalCount":130,"pubmedCount":null,"jensenScore":981.354997,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":43,"knowledgeAvailability":61.11210030380696,"pubTatorScore":2.8357285163943353,"self":"https://pharos.nih.gov/idg/api/v1/targets(8584)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1334,"href":"https://pharos.nih.gov/idg/api/v1/targets(8584)/properties"},"_links":{"count":1501,"href":"https://pharos.nih.gov/idg/api/v1/targets(8584)/links"},"_synonyms":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(8584)/synonyms"},"_publications":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(8584)/publications"},"_namespace":null},{"id":8585,"version":2,"created":1554918116000,"modified":1554918116000,"deprecated":false,"name":"Olfactory receptor 52E5","accession":"Q8NH55","gene":"OR52E5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.370141096721209,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8585)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8585)/properties"},"_links":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8585)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8585)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8585)/publications"},"_namespace":null},{"id":8586,"version":2,"created":1554918116000,"modified":1554918118000,"deprecated":false,"name":"Olfactory receptor 9A2","accession":"Q8NGT5","gene":"OR9A2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":48,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":142,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.278822979398633,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8586)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8586)/properties"},"_links":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(8586)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8586)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8586)/publications"},"_namespace":null},{"id":8587,"version":2,"created":1554918119000,"modified":1554918119000,"deprecated":false,"name":"Keratin-associated protein 10-1","accession":"P60331","gene":"KRTAP10-1","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.20202,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.756503865170416,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8587)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8587)/properties"},"_links":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8587)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8587)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8587)/publications"},"_namespace":null},{"id":8588,"version":2,"created":1554918119000,"modified":1554918121000,"deprecated":false,"name":"Olfactory receptor 2A1/2A42","accession":"Q8NGT9","gene":"OR2A42","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.071429,"patentCount":483,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.605249848549601,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8588)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(8588)/properties"},"_links":{"count":654,"href":"https://pharos.nih.gov/idg/api/v1/targets(8588)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8588)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8588)/publications"},"_namespace":null},{"id":8589,"version":2,"created":1554918121000,"modified":1554918123000,"deprecated":false,"name":"Olfactory receptor 51Q1","accession":"Q8NH59","gene":"OR51Q1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.7024305364455253,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.198413,"patentCount":100,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.420129995526043,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8589)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8589)/properties"},"_links":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(8589)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8589)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8589)/publications"},"_namespace":null},{"id":8590,"version":3,"created":1554918123000,"modified":1555038388000,"deprecated":false,"name":"Peptide YY","accession":"P10082","gene":"PYY","description":"This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.089007614450954,"antibodyCount":306,"monoclonalCount":61,"pubmedCount":null,"jensenScore":1283.437526,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":28.201463287265714,"pubTatorScore":2.8908305296934866,"self":"https://pharos.nih.gov/idg/api/v1/targets(8590)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(8590)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(8590)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8590)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8590)/publications"},"_namespace":null},{"id":8591,"version":2,"created":1554918127000,"modified":1554918131000,"deprecated":false,"name":"Transformer-2 protein homolog beta","accession":"P62995","gene":"TRA2B","description":"Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.610907131447923,"antibodyCount":133,"monoclonalCount":13,"pubmedCount":null,"jensenScore":39.438026,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.58318617991982,"pubTatorScore":1.580408599300236,"self":"https://pharos.nih.gov/idg/api/v1/targets(8591)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":483,"href":"https://pharos.nih.gov/idg/api/v1/targets(8591)/properties"},"_links":{"count":1189,"href":"https://pharos.nih.gov/idg/api/v1/targets(8591)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8591)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8591)/publications"},"_namespace":null},{"id":8592,"version":2,"created":1554918132000,"modified":1554918137000,"deprecated":false,"name":"Oxysterol-binding protein 1","accession":"P22059","gene":"OSBP","description":"Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2239449281561914,"antibodyCount":160,"monoclonalCount":19,"pubmedCount":null,"jensenScore":167.624944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.620408502740524,"pubTatorScore":1.7907535341335015,"self":"https://pharos.nih.gov/idg/api/v1/targets(8592)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(8592)/properties"},"_links":{"count":1173,"href":"https://pharos.nih.gov/idg/api/v1/targets(8592)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8592)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8592)/publications"},"_namespace":null},{"id":8593,"version":2,"created":1554918138000,"modified":1554918144000,"deprecated":false,"name":"Nestin","accession":"P48681","gene":"NES","description":"Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.385366392158208,"antibodyCount":741,"monoclonalCount":310,"pubmedCount":null,"jensenScore":2273.69326,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.522748598895205,"pubTatorScore":2.619216127776974,"self":"https://pharos.nih.gov/idg/api/v1/targets(8593)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":557,"href":"https://pharos.nih.gov/idg/api/v1/targets(8593)/properties"},"_links":{"count":1282,"href":"https://pharos.nih.gov/idg/api/v1/targets(8593)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8593)/synonyms"},"_publications":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(8593)/publications"},"_namespace":null},{"id":8594,"version":2,"created":1554918146000,"modified":1554918149000,"deprecated":false,"name":"Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform","accession":"P46020","gene":"PHKA1","description":"Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.1781429711473894,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.343033,"patentCount":936,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.00133094944145,"pubTatorScore":1.0726202322121405,"self":"https://pharos.nih.gov/idg/api/v1/targets(8594)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(8594)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(8594)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8594)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8594)/publications"},"_namespace":null},{"id":8595,"version":2,"created":1554918150000,"modified":1554918152000,"deprecated":false,"name":"Rhomboid domain-containing protein 2","accession":"Q6NTF9","gene":"RHBDD2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6241101364139814,"antibodyCount":33,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.301587,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.37580955530259,"pubTatorScore":0.8462045145286261,"self":"https://pharos.nih.gov/idg/api/v1/targets(8595)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8595)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(8595)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8595)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8595)/publications"},"_namespace":null},{"id":8596,"version":3,"created":1554918153000,"modified":1554918243000,"deprecated":false,"name":"Alpha-1B adrenergic receptor","accession":"P35368","gene":"ADRA1B","description":"This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.3059417422182595,"antibodyCount":364,"monoclonalCount":21,"pubmedCount":null,"jensenScore":201.544892,"patentCount":1635,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.462444116867196,"pubTatorScore":2.1438109067770736,"self":"https://pharos.nih.gov/idg/api/v1/targets(8596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(8596)/properties"},"_links":{"count":1453,"href":"https://pharos.nih.gov/idg/api/v1/targets(8596)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(8596)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8596)/publications"},"_namespace":null},{"id":8597,"version":3,"created":1554918246000,"modified":1554918366000,"deprecated":false,"name":"Histamine H1 receptor","accession":"P35367","gene":"HRH1","description":"In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-3.024848620246225,"antibodyCount":393,"monoclonalCount":50,"pubmedCount":null,"jensenScore":1031.12481,"patentCount":9225,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.03254416458657,"pubTatorScore":2.1724174583741864,"self":"https://pharos.nih.gov/idg/api/v1/targets(8597)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(8597)/properties"},"_links":{"count":1524,"href":"https://pharos.nih.gov/idg/api/v1/targets(8597)/links"},"_synonyms":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(8597)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8597)/publications"},"_namespace":null},{"id":8598,"version":2,"created":1554918368000,"modified":1554918370000,"deprecated":false,"name":"DNA dC->dU-editing enzyme APOBEC-3H","accession":"Q6NTF7","gene":"APOBEC3H","description":"DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5798897164087504,"antibodyCount":28,"monoclonalCount":3,"pubmedCount":null,"jensenScore":44.394433,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.182426642244895,"pubTatorScore":1.528333930829176,"self":"https://pharos.nih.gov/idg/api/v1/targets(8598)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(8598)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(8598)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8598)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8598)/publications"},"_namespace":null},{"id":8599,"version":3,"created":1554918371000,"modified":1555038390000,"deprecated":false,"name":"Olfactory receptor 13J1","accession":"Q8NGT2","gene":"OR13J1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":201,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":11.452523581235157,"pubTatorScore":1.0575392957485195,"self":"https://pharos.nih.gov/idg/api/v1/targets(8599)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8599)/properties"},"_links":{"count":583,"href":"https://pharos.nih.gov/idg/api/v1/targets(8599)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8599)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8599)/publications"},"_namespace":null},{"id":8600,"version":2,"created":1554918373000,"modified":1554918374000,"deprecated":false,"name":"Olfactory receptor 52N1","accession":"Q8NH53","gene":"OR52N1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":186,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.7871721007443035,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8600)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8600)/properties"},"_links":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8600)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8600)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8600)/publications"},"_namespace":null},{"id":8601,"version":2,"created":1554918374000,"modified":1554918374000,"deprecated":false,"name":"Olfactory receptor 8K5","accession":"Q8NH50","gene":"OR8K5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":1.0,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.090909,"patentCount":105,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.2035278888826975,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8601)/properties"},"_links":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8601)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8601)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8601)/publications"},"_namespace":null},{"id":8602,"version":2,"created":1554918374000,"modified":1554918375000,"deprecated":false,"name":"Olfactory receptor 13C9","accession":"Q8NGT0","gene":"OR13C9","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":233,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.657656163174476,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8602)/properties"},"_links":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8602)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8602)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8602)/publications"},"_namespace":null},{"id":8603,"version":3,"created":1554918375000,"modified":1555038391000,"deprecated":false,"name":"Olfactory receptor 2K2","accession":"Q8NGT1","gene":"OR2K2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":93,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.576923,"patentCount":131,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":11.046106142394029,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(8603)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8603)/properties"},"_links":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(8603)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8603)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8603)/publications"},"_namespace":null},{"id":8604,"version":3,"created":1554918376000,"modified":1555038392000,"deprecated":false,"name":"Protein CASC1","accession":"Q6TDU7","gene":"CASC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8649216308715658,"antibodyCount":15,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.772836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.631722934565833,"pubTatorScore":0.8023350373590007,"self":"https://pharos.nih.gov/idg/api/v1/targets(8604)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(8604)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(8604)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8604)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8604)/publications"},"_namespace":null},{"id":8605,"version":2,"created":1554918379000,"modified":1554918380000,"deprecated":false,"name":"Olfactory receptor 8K3","accession":"Q8NH51","gene":"OR8K3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":64,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":74,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.216098913560883,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8605)/properties"},"_links":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8605)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8605)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8605)/publications"},"_namespace":null},{"id":8606,"version":2,"created":1554918380000,"modified":1554918381000,"deprecated":false,"name":"Olfactory receptor 13C4","accession":"Q8NGS5","gene":"OR13C4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-0.17609125688420882,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.5,"patentCount":173,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.386038564577431,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(8606)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8606)/properties"},"_links":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8606)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8606)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8606)/publications"},"_namespace":null},{"id":8607,"version":2,"created":1554918381000,"modified":1554918381000,"deprecated":false,"name":"Olfactory receptor 13C3","accession":"Q8NGS6","gene":"OR13C3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":153,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.382964061091265,"pubTatorScore":0.985276713227949,"self":"https://pharos.nih.gov/idg/api/v1/targets(8607)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8607)/properties"},"_links":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8607)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8607)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8607)/publications"},"_namespace":null},{"id":8608,"version":2,"created":1554918381000,"modified":1554918382000,"deprecated":false,"name":"Olfactory receptor 1J1","accession":"Q8NGS3","gene":"OR1J1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-0.5440680378358584,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.5,"patentCount":176,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.70049879412206,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8608)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8608)/properties"},"_links":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(8608)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8608)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8608)/publications"},"_namespace":null},{"id":8609,"version":2,"created":1554918382000,"modified":1554918382000,"deprecated":false,"name":"Olfactory receptor 4L1","accession":"Q8NH43","gene":"OR4L1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":150,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.8965298271420465,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8609)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8609)/properties"},"_links":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8609)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8609)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8609)/publications"},"_namespace":null},{"id":8610,"version":2,"created":1554918382000,"modified":1554918383000,"deprecated":false,"name":"Olfactory receptor 13F1","accession":"Q8NGS4","gene":"OR13F1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":105,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.972348886501305,"pubTatorScore":0.9700367611120393,"self":"https://pharos.nih.gov/idg/api/v1/targets(8610)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8610)/properties"},"_links":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8610)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8610)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8610)/publications"},"_namespace":null},{"id":8611,"version":2,"created":1554918383000,"modified":1554918383000,"deprecated":false,"name":"Olfactory receptor 4X1","accession":"Q8NH49","gene":"OR4X1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":71,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.666667,"patentCount":110,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.890496132075247,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8611)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8611)/properties"},"_links":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8611)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8611)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8611)/publications"},"_namespace":null},{"id":8612,"version":2,"created":1554918384000,"modified":1554918386000,"deprecated":false,"name":"Serine/threonine-protein kinase Nek10","accession":"Q6ZWH5","gene":"NEK10","description":null,"idgFamily":"Kinase","idgTDL":"Tdark","novelty":-0.45108499214441566,"antibodyCount":50,"monoclonalCount":10,"pubmedCount":null,"jensenScore":2.231209,"patentCount":974,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.817519565253864,"pubTatorScore":0.43181021452421736,"self":"https://pharos.nih.gov/idg/api/v1/targets(8612)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(8612)/properties"},"_links":{"count":824,"href":"https://pharos.nih.gov/idg/api/v1/targets(8612)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8612)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8612)/publications"},"_namespace":null},{"id":8613,"version":2,"created":1554918387000,"modified":1554918387000,"deprecated":false,"name":"Olfactory receptor 13C2","accession":"Q8NGS9","gene":"OR13C2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":219,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.615988307525072,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8613)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8613)/properties"},"_links":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8613)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8613)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8613)/publications"},"_namespace":null},{"id":8614,"version":2,"created":1554918387000,"modified":1554918388000,"deprecated":false,"name":"Olfactory receptor 13C8","accession":"Q8NGS7","gene":"OR13C8","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.38021124171160603,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.416667,"patentCount":111,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.328734957191163,"pubTatorScore":-0.38021089427615945,"self":"https://pharos.nih.gov/idg/api/v1/targets(8614)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8614)/properties"},"_links":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8614)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8614)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8614)/publications"},"_namespace":null},{"id":8615,"version":2,"created":1554918388000,"modified":1554918390000,"deprecated":false,"name":"Calcitonin gene-related peptide 2","accession":"P10092","gene":"CALCB","description":"CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4659018984581682,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":27.310194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.785973636977726,"pubTatorScore":1.7428526443752212,"self":"https://pharos.nih.gov/idg/api/v1/targets(8615)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(8615)/properties"},"_links":{"count":664,"href":"https://pharos.nih.gov/idg/api/v1/targets(8615)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8615)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8615)/publications"},"_namespace":null},{"id":8616,"version":3,"created":1554918390000,"modified":1555038393000,"deprecated":false,"name":"Olfactory receptor 13C5","accession":"Q8NGS8","gene":"OR13C5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1,"patentCount":123,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":7.731357098167669,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8616)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8616)/properties"},"_links":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8616)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8616)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8616)/publications"},"_namespace":null},{"id":8617,"version":4,"created":1554918391000,"modified":1555038394000,"deprecated":false,"name":"Mu-type opioid receptor","accession":"P35372","gene":"OPRM1","description":"Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects (PubMed:20525224). Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity (PubMed:16580639).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-3.253124593346194,"antibodyCount":392,"monoclonalCount":15,"pubmedCount":null,"jensenScore":1716.825855,"patentCount":90709,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":44.0909135873519,"pubTatorScore":3.104341856491005,"self":"https://pharos.nih.gov/idg/api/v1/targets(8617)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/properties"},"_links":{"count":2812,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/links"},"_synonyms":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/synonyms"},"_publications":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(8617)/publications"},"_namespace":null},{"id":8618,"version":2,"created":1554919072000,"modified":1554919073000,"deprecated":false,"name":"Olfactory receptor 5B3","accession":"Q8NH48","gene":"OR5B3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":29,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":145,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.909099291461284,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(8618)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/properties"},"_links":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8618)/publications"},"_namespace":null},{"id":8619,"version":2,"created":1554919073000,"modified":1554919079000,"deprecated":false,"name":"Proliferation marker protein Ki-67","accession":"P46013","gene":"MKI67","description":"Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5010598311438956,"antibodyCount":1434,"monoclonalCount":866,"pubmedCount":null,"jensenScore":270.347083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.00752057152913,"pubTatorScore":2.3258841400989714,"self":"https://pharos.nih.gov/idg/api/v1/targets(8619)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/properties"},"_links":{"count":1605,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/synonyms"},"_publications":{"count":643,"href":"https://pharos.nih.gov/idg/api/v1/targets(8619)/publications"},"_namespace":null},{"id":8620,"version":2,"created":1554919081000,"modified":1554919085000,"deprecated":false,"name":"Phosphorylase b kinase regulatory subunit alpha, liver isoform","accession":"P46019","gene":"PHKA2","description":"Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.2111142918054196,"antibodyCount":59,"monoclonalCount":12,"pubmedCount":null,"jensenScore":153.219909,"patentCount":20373,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.65851059251749,"pubTatorScore":2.090012188901781,"self":"https://pharos.nih.gov/idg/api/v1/targets(8620)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(8620)/properties"},"_links":{"count":1062,"href":"https://pharos.nih.gov/idg/api/v1/targets(8620)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8620)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8620)/publications"},"_namespace":null},{"id":8621,"version":2,"created":1554919086000,"modified":1554919088000,"deprecated":false,"name":"Pleckstrin homology domain-containing family M member 3","accession":"Q6ZWE6","gene":"PLEKHM3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.6921459771752112,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":44.659494,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.173812598659616,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(8621)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(8621)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(8621)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8621)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8621)/publications"},"_namespace":null},{"id":8622,"version":3,"created":1554919089000,"modified":1554919606000,"deprecated":false,"name":"Prostaglandin G/H synthase 2","accession":"P35354","gene":"PTGS2","description":"Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-4.068338760315519,"antibodyCount":731,"monoclonalCount":194,"pubmedCount":null,"jensenScore":12504.507703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.13367853500597,"pubTatorScore":3.8451523457642045,"self":"https://pharos.nih.gov/idg/api/v1/targets(8622)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2532,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/properties"},"_links":{"count":4751,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/links"},"_synonyms":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/synonyms"},"_publications":{"count":2002,"href":"https://pharos.nih.gov/idg/api/v1/targets(8622)/publications"},"_namespace":null},{"id":8623,"version":3,"created":1554919618000,"modified":1555038402000,"deprecated":false,"name":"Shugoshin 2","accession":"Q562F6","gene":"SGO2","description":"Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.319709006318296,"antibodyCount":90,"monoclonalCount":0,"pubmedCount":null,"jensenScore":22.256813,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":0.0,"pubTatorScore":0.9555808227954455,"self":"https://pharos.nih.gov/idg/api/v1/targets(8623)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8623)/publications"},"_namespace":null},{"id":8624,"version":2,"created":1554919622000,"modified":1554919623000,"deprecated":false,"name":"Olfactory receptor 1J4","accession":"Q8NGS1","gene":"OR1J4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":64,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":199,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.855747665806545,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8624)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8624)/properties"},"_links":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8624)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8624)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8624)/publications"},"_namespace":null},{"id":8625,"version":2,"created":1554919623000,"modified":1554919623000,"deprecated":false,"name":"Olfactory receptor 4K15","accession":"Q8NH41","gene":"OR4K15","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":137,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.980461662179366,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8625)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8625)/properties"},"_links":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8625)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8625)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8625)/publications"},"_namespace":null},{"id":8626,"version":2,"created":1554919623000,"modified":1554919624000,"deprecated":false,"name":"Olfactory receptor 1J2","accession":"Q8NGS2","gene":"OR1J2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-1.171970093870521,"antibodyCount":13,"monoclonalCount":1,"pubmedCount":null,"jensenScore":14.473434,"patentCount":6283,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.636354372819962,"pubTatorScore":1.1681371996945822,"self":"https://pharos.nih.gov/idg/api/v1/targets(8626)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8626)/properties"},"_links":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8626)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8626)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8626)/publications"},"_namespace":null},{"id":8627,"version":2,"created":1554919625000,"modified":1554919625000,"deprecated":false,"name":"Olfactory receptor 4K13","accession":"Q8NH42","gene":"OR4K13","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":57,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":91,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.360492396758435,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8627)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8627)/properties"},"_links":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8627)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8627)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8627)/publications"},"_namespace":null},{"id":8628,"version":2,"created":1554919625000,"modified":1554919653000,"deprecated":false,"name":"DNA topoisomerase 2-alpha","accession":"P11388","gene":"TOP2A","description":"Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.8826425170455208,"antibodyCount":847,"monoclonalCount":416,"pubmedCount":null,"jensenScore":722.968733,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":54.05158635149615,"pubTatorScore":2.7847948057750074,"self":"https://pharos.nih.gov/idg/api/v1/targets(8628)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":760,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/properties"},"_links":{"count":1413,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/links"},"_synonyms":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/synonyms"},"_publications":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(8628)/publications"},"_namespace":null},{"id":8629,"version":3,"created":1554919655000,"modified":1554919712000,"deprecated":false,"name":"DNA topoisomerase 1","accession":"P11387","gene":"TOP1","description":"Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.6170109380355404,"antibodyCount":248,"monoclonalCount":73,"pubmedCount":null,"jensenScore":4015.403635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.24496818732609,"pubTatorScore":2.688272165258963,"self":"https://pharos.nih.gov/idg/api/v1/targets(8629)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/properties"},"_links":{"count":1560,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/links"},"_synonyms":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/synonyms"},"_publications":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(8629)/publications"},"_namespace":null},{"id":8630,"version":2,"created":1554919714000,"modified":1554919714000,"deprecated":false,"name":"Olfactory receptor 1N1","accession":"Q8NGS0","gene":"OR1N1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":87,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":242,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.148270222163339,"pubTatorScore":1.0969100130080565,"self":"https://pharos.nih.gov/idg/api/v1/targets(8630)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8630)/properties"},"_links":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(8630)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8630)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8630)/publications"},"_namespace":null},{"id":8631,"version":2,"created":1554919714000,"modified":1554919715000,"deprecated":false,"name":"Olfactory receptor 6S1","accession":"Q8NH40","gene":"OR6S1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":183,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.790900541681532,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8631)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8631)/properties"},"_links":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8631)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8631)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8631)/publications"},"_namespace":null},{"id":8632,"version":3,"created":1554919715000,"modified":1555038403000,"deprecated":false,"name":"Olfactory receptor 5C1","accession":"Q8NGR4","gene":"OR5C1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":9,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":197,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":10.095946566928006,"pubTatorScore":1.0791812460476249,"self":"https://pharos.nih.gov/idg/api/v1/targets(8632)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8632)/properties"},"_links":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8632)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8632)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8632)/publications"},"_namespace":null},{"id":8633,"version":2,"created":1554919716000,"modified":1554919716000,"deprecated":false,"name":"Olfactory receptor 1L4","accession":"Q8NGR5","gene":"OR1L4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":139,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.676378172014259,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(8633)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8633)/properties"},"_links":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8633)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8633)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8633)/publications"},"_namespace":null},{"id":8634,"version":3,"created":1554919716000,"modified":1555038403000,"deprecated":false,"name":"Sodium leak channel non-selective protein","accession":"Q8IZF0","gene":"NALCN","description":"Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.7237708009719388,"antibodyCount":62,"monoclonalCount":38,"pubmedCount":null,"jensenScore":54.126938,"patentCount":3662,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.14072576267732,"pubTatorScore":1.3452103149007706,"self":"https://pharos.nih.gov/idg/api/v1/targets(8634)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(8634)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(8634)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8634)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8634)/publications"},"_namespace":null},{"id":8635,"version":2,"created":1554919721000,"modified":1554919722000,"deprecated":false,"name":"Olfactory receptor 1L6","accession":"Q8NGR2","gene":"OR1L6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":349,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.02857447456262,"pubTatorScore":0.8129133566428556,"self":"https://pharos.nih.gov/idg/api/v1/targets(8635)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8635)/properties"},"_links":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8635)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8635)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8635)/publications"},"_namespace":null},{"id":8636,"version":2,"created":1554919722000,"modified":1554919723000,"deprecated":false,"name":"Olfactory receptor 1K1","accession":"Q8NGR3","gene":"OR1K1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":625,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.663536563564838,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8636)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8636)/properties"},"_links":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(8636)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8636)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8636)/publications"},"_namespace":null},{"id":8637,"version":2,"created":1554919723000,"modified":1554919726000,"deprecated":false,"name":"Adhesion G protein-coupled receptor F5","accession":"Q8IZF2","gene":"ADGRF5","description":"Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-0.9324993790787345,"antibodyCount":161,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.803909,"patentCount":2334,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.29366446897796,"pubTatorScore":0.48963580105744103,"self":"https://pharos.nih.gov/idg/api/v1/targets(8637)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(8637)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(8637)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8637)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8637)/publications"},"_namespace":null},{"id":8638,"version":2,"created":1554919727000,"modified":1554919729000,"deprecated":false,"name":"Olfactory receptor 1L8","accession":"Q8NGR8","gene":"OR1L8","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":157,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.975545605037453,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8638)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(8638)/properties"},"_links":{"count":619,"href":"https://pharos.nih.gov/idg/api/v1/targets(8638)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8638)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8638)/publications"},"_namespace":null},{"id":8639,"version":2,"created":1554919729000,"modified":1554919731000,"deprecated":false,"name":"Adhesion G protein-coupled receptor F4","accession":"Q8IZF3","gene":"ADGRF4","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.325639513734491,"antibodyCount":165,"monoclonalCount":7,"pubmedCount":null,"jensenScore":1.739993,"patentCount":503,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.40661835729771,"pubTatorScore":-0.25267987754916815,"self":"https://pharos.nih.gov/idg/api/v1/targets(8639)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(8639)/properties"},"_links":{"count":703,"href":"https://pharos.nih.gov/idg/api/v1/targets(8639)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8639)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8639)/publications"},"_namespace":null},{"id":8640,"version":2,"created":1554919732000,"modified":1554919732000,"deprecated":false,"name":"Serine protease inhibitor Kazal-type 14","accession":"Q6IE38","gene":"SPINK14","description":"May be a serine protease inhibitor.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.683725555921799,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8640)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8640)/properties"},"_links":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8640)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8640)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8640)/publications"},"_namespace":null},{"id":8641,"version":2,"created":1554919732000,"modified":1554919733000,"deprecated":false,"name":"Olfactory receptor 1N2","accession":"Q8NGR9","gene":"OR1N2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":176,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.878551545278954,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8641)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8641)/properties"},"_links":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8641)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8641)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8641)/publications"},"_namespace":null},{"id":8642,"version":2,"created":1554919733000,"modified":1554919733000,"deprecated":false,"name":"Olfactory receptor 1B1","accession":"Q8NGR6","gene":"OR1B1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-0.34242268516515106,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.166667,"patentCount":501,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.773365957404923,"pubTatorScore":0.8871413408975175,"self":"https://pharos.nih.gov/idg/api/v1/targets(8642)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8642)/properties"},"_links":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8642)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8642)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8642)/publications"},"_namespace":null},{"id":8643,"version":3,"created":1554919733000,"modified":1555038406000,"deprecated":false,"name":"Adhesion G-protein coupled receptor G5","accession":"Q8IZF4","gene":"ADGRG5","description":"Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.4241450669557994,"antibodyCount":48,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.815839,"patentCount":750,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":79,"knowledgeAvailability":22.36386915418275,"pubTatorScore":0.2840172240648245,"self":"https://pharos.nih.gov/idg/api/v1/targets(8643)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(8643)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(8643)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8643)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8643)/publications"},"_namespace":null},{"id":8644,"version":2,"created":1554919736000,"modified":1554919736000,"deprecated":false,"name":"Ovostatin homolog 1","accession":"Q6IE37","gene":"OVOS1","description":"Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8644)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8644)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8644)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8644)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8644)/publications"},"_namespace":null},{"id":8645,"version":2,"created":1554919736000,"modified":1554919738000,"deprecated":false,"name":"Adhesion G-protein coupled receptor F3","accession":"Q8IZF5","gene":"ADGRF3","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.2760176733485849,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.848174,"patentCount":1471,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.990099023821244,"pubTatorScore":0.37627138362892454,"self":"https://pharos.nih.gov/idg/api/v1/targets(8645)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(8645)/properties"},"_links":{"count":838,"href":"https://pharos.nih.gov/idg/api/v1/targets(8645)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8645)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8645)/publications"},"_namespace":null},{"id":8646,"version":2,"created":1554919739000,"modified":1554919739000,"deprecated":false,"name":"Ovostatin homolog 2","accession":"Q6IE36","gene":"OVOS2","description":"Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.9934050340544704,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8646)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8646)/properties"},"_links":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8646)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8646)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8646)/publications"},"_namespace":null},{"id":8647,"version":2,"created":1554919739000,"modified":1554919740000,"deprecated":false,"name":"Olfactory receptor 4C3","accession":"Q8NH37","gene":"OR4C3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":126,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.920659839515315,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8647)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8647)/properties"},"_links":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8647)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8647)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8647)/publications"},"_namespace":null},{"id":8648,"version":2,"created":1554919740000,"modified":1554919742000,"deprecated":false,"name":"Adhesion G-protein coupled receptor G4","accession":"Q8IZF6","gene":"ADGRG4","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":0.06643985959543362,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.351164,"patentCount":613,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.83219866772709,"pubTatorScore":0.28936104421002534,"self":"https://pharos.nih.gov/idg/api/v1/targets(8648)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(8648)/properties"},"_links":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(8648)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8648)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8648)/publications"},"_namespace":null},{"id":8649,"version":2,"created":1554919742000,"modified":1554919746000,"deprecated":false,"name":"NAD-dependent malic enzyme, mitochondrial","accession":"P23368","gene":"ME2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9333662633667055,"antibodyCount":117,"monoclonalCount":9,"pubmedCount":null,"jensenScore":84.552541,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.24658197794908,"pubTatorScore":2.4250281438543286,"self":"https://pharos.nih.gov/idg/api/v1/targets(8649)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(8649)/properties"},"_links":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8649)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(8649)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8649)/publications"},"_namespace":null},{"id":8650,"version":2,"created":1554919747000,"modified":1554919748000,"deprecated":false,"name":"Adhesion G-protein coupled receptor F2","accession":"Q8IZF7","gene":"ADGRF2","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":0.2479390735265127,"antibodyCount":64,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.57035,"patentCount":438,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.290603512580262,"pubTatorScore":0.2154300146598476,"self":"https://pharos.nih.gov/idg/api/v1/targets(8650)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8650)/properties"},"_links":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(8650)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8650)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8650)/publications"},"_namespace":null},{"id":8651,"version":2,"created":1554919749000,"modified":1554919755000,"deprecated":false,"name":"Excitatory amino acid transporter 4","accession":"P48664","gene":"SLC1A6","description":"Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.8931382841150142,"antibodyCount":107,"monoclonalCount":10,"pubmedCount":null,"jensenScore":75.787411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.089740035915565,"pubTatorScore":1.6271624280307255,"self":"https://pharos.nih.gov/idg/api/v1/targets(8651)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(8651)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(8651)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8651)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8651)/publications"},"_namespace":null},{"id":8652,"version":2,"created":1554919756000,"modified":1554919760000,"deprecated":false,"name":"Methylmalonyl-CoA mutase, mitochondrial","accession":"P22033","gene":"MUT","description":"Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.5169021840460672,"antibodyCount":99,"monoclonalCount":33,"pubmedCount":null,"jensenScore":305.267265,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.71307330032971,"pubTatorScore":2.595123359987439,"self":"https://pharos.nih.gov/idg/api/v1/targets(8652)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":484,"href":"https://pharos.nih.gov/idg/api/v1/targets(8652)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(8652)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8652)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8652)/publications"},"_namespace":null},{"id":8653,"version":2,"created":1554919761000,"modified":1554919764000,"deprecated":false,"name":"Keratin, type II cytoskeletal 6C","accession":"P48668","gene":"KRT6C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4727243159715588,"antibodyCount":89,"monoclonalCount":25,"pubmedCount":null,"jensenScore":2.105681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.791092152715482,"pubTatorScore":0.9897126731549466,"self":"https://pharos.nih.gov/idg/api/v1/targets(8653)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(8653)/properties"},"_links":{"count":737,"href":"https://pharos.nih.gov/idg/api/v1/targets(8653)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8653)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8653)/publications"},"_namespace":null},{"id":8654,"version":2,"created":1554919765000,"modified":1554919769000,"deprecated":false,"name":"Tryptophan--tRNA ligase, cytoplasmic","accession":"P23381","gene":"WARS","description":"Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7452006509865248,"antibodyCount":163,"monoclonalCount":30,"pubmedCount":null,"jensenScore":518.573758,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.7074485736668,"pubTatorScore":2.8127727855108198,"self":"https://pharos.nih.gov/idg/api/v1/targets(8654)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(8654)/properties"},"_links":{"count":1155,"href":"https://pharos.nih.gov/idg/api/v1/targets(8654)/links"},"_synonyms":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(8654)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8654)/publications"},"_namespace":null},{"id":8655,"version":3,"created":1554919770000,"modified":1554919848000,"deprecated":false,"name":"Somatostatin receptor type 5","accession":"P35346","gene":"SSTR5","description":"Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.1065800395890153,"antibodyCount":191,"monoclonalCount":27,"pubmedCount":null,"jensenScore":120.838952,"patentCount":12063,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.459396759459523,"pubTatorScore":2.2535505516039964,"self":"https://pharos.nih.gov/idg/api/v1/targets(8655)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(8655)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(8655)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8655)/synonyms"},"_publications":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8655)/publications"},"_namespace":null},{"id":8656,"version":2,"created":1554919850000,"modified":1554919856000,"deprecated":false,"name":"Low-density lipoprotein receptor-related protein 5","accession":"O75197","gene":"LRP5","description":"Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patterning of the epiblast during gastrulation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1042902294562027,"antibodyCount":302,"monoclonalCount":46,"pubmedCount":null,"jensenScore":1247.478288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.57103700108209,"pubTatorScore":2.638244934037356,"self":"https://pharos.nih.gov/idg/api/v1/targets(8656)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":705,"href":"https://pharos.nih.gov/idg/api/v1/targets(8656)/properties"},"_links":{"count":1305,"href":"https://pharos.nih.gov/idg/api/v1/targets(8656)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(8656)/synonyms"},"_publications":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(8656)/publications"},"_namespace":null},{"id":8657,"version":3,"created":1554919858000,"modified":1555038407000,"deprecated":false,"name":"Olfactory receptor 13A1","accession":"Q8NGR1","gene":"OR13A1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":141,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":12.171962790419412,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8657)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(8657)/properties"},"_links":{"count":607,"href":"https://pharos.nih.gov/idg/api/v1/targets(8657)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8657)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8657)/publications"},"_namespace":null},{"id":8658,"version":2,"created":1554919860000,"modified":1554919862000,"deprecated":false,"name":"WD repeat-containing protein 81","accession":"Q562E7","gene":"WDR81","description":"Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2732869689233977,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.633371,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.63944526801961,"pubTatorScore":0.5723316499822046,"self":"https://pharos.nih.gov/idg/api/v1/targets(8658)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(8658)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(8658)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8658)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8658)/publications"},"_namespace":null},{"id":8659,"version":3,"created":1554919863000,"modified":1554920032000,"deprecated":false,"name":"Alpha-1A adrenergic receptor","accession":"P35348","gene":"ADRA1A","description":"This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.186818131947155,"antibodyCount":236,"monoclonalCount":28,"pubmedCount":null,"jensenScore":155.50955,"patentCount":4961,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.962067507029516,"pubTatorScore":2.3003362992609366,"self":"https://pharos.nih.gov/idg/api/v1/targets(8659)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(8659)/properties"},"_links":{"count":1990,"href":"https://pharos.nih.gov/idg/api/v1/targets(8659)/links"},"_synonyms":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(8659)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8659)/publications"},"_namespace":null},{"id":8660,"version":2,"created":1554920035000,"modified":1554920038000,"deprecated":false,"name":"Krueppel-related zinc finger protein 1","accession":"P10072","gene":"HKR1","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.9050245022796607,"antibodyCount":150,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.095961,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.94886064091578,"pubTatorScore":0.48902043106861287,"self":"https://pharos.nih.gov/idg/api/v1/targets(8660)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(8660)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(8660)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8660)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8660)/publications"},"_namespace":null},{"id":8661,"version":2,"created":1554920038000,"modified":1554920039000,"deprecated":false,"name":"Olfactory receptor 1S2","accession":"Q8NGQ3","gene":"OR1S2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":65,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":147,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.923489388127795,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8661)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8661)/properties"},"_links":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8661)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8661)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8661)/publications"},"_namespace":null},{"id":8662,"version":3,"created":1554920039000,"modified":1555038408000,"deprecated":false,"name":"Zinc finger and SCAN domain-containing protein 22","accession":"P10073","gene":"ZSCAN22","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.40576534695952005,"antibodyCount":133,"monoclonalCount":11,"pubmedCount":null,"jensenScore":0.180556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.59860879873305,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8662)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(8662)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(8662)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8662)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8662)/publications"},"_namespace":null},{"id":8663,"version":2,"created":1554920042000,"modified":1554920045000,"deprecated":false,"name":"Olfactory receptor 10Q1","accession":"Q8NGQ4","gene":"OR10Q1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":8,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":212,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.506120936435021,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8663)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8663)/properties"},"_links":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(8663)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8663)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8663)/publications"},"_namespace":null},{"id":8664,"version":3,"created":1554920045000,"modified":1555038410000,"deprecated":false,"name":"Telomere zinc finger-associated protein","accession":"P10074","gene":"ZBTB48","description":"Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.5968191624275041,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.785353,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":65,"knowledgeAvailability":33.726230277961506,"pubTatorScore":0.5933563018259913,"self":"https://pharos.nih.gov/idg/api/v1/targets(8664)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(8664)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(8664)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8664)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8664)/publications"},"_namespace":null},{"id":8665,"version":2,"created":1554920048000,"modified":1554920049000,"deprecated":false,"name":"Olfactory receptor 4F5","accession":"Q8NH21","gene":"OR4F5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":89,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.2374408564256636,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8665)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8665)/properties"},"_links":{"count":499,"href":"https://pharos.nih.gov/idg/api/v1/targets(8665)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8665)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8665)/publications"},"_namespace":null},{"id":8666,"version":2,"created":1554920050000,"modified":1554920050000,"deprecated":false,"name":"Olfactory receptor 9G4","accession":"Q8NGQ1","gene":"OR9G4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":84,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":133,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.879382254769215,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8666)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8666)/properties"},"_links":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8666)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8666)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8666)/publications"},"_namespace":null},{"id":8667,"version":2,"created":1554920050000,"modified":1554920050000,"deprecated":false,"name":"Olfactory receptor 6Q1","accession":"Q8NGQ2","gene":"OR6Q1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":95,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0625,"patentCount":137,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.843188119233764,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(8667)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8667)/properties"},"_links":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(8667)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8667)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8667)/publications"},"_namespace":null},{"id":8668,"version":2,"created":1554920051000,"modified":1554920052000,"deprecated":false,"name":"Zinc finger protein GLI4","accession":"P10075","gene":"GLI4","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.12493873660829995,"antibodyCount":121,"monoclonalCount":15,"pubmedCount":null,"jensenScore":1.916667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.31632103872617,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8668)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8668)/properties"},"_links":{"count":716,"href":"https://pharos.nih.gov/idg/api/v1/targets(8668)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8668)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8668)/publications"},"_namespace":null},{"id":8669,"version":2,"created":1554920053000,"modified":1554920054000,"deprecated":false,"name":"Olfactory receptor 9Q1","accession":"Q8NGQ5","gene":"OR9Q1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":90,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.111111,"patentCount":180,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.3011584482745,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(8669)/properties"},"_links":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(8669)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8669)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8669)/publications"},"_namespace":null},{"id":8670,"version":3,"created":1554920054000,"modified":1555038412000,"deprecated":false,"name":"Protein-associating with the carboxyl-terminal domain of ezrin","accession":"Q8IZE3","gene":"SCYL3","description":"May play a role in regulating cell adhesion/migration complexes in migrating cells.","idgFamily":"Kinase","idgTDL":"Tdark","novelty":-0.49732463832626667,"antibodyCount":162,"monoclonalCount":52,"pubmedCount":null,"jensenScore":3.23772,"patentCount":792,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":34.458686377891986,"pubTatorScore":0.49732462106729064,"self":"https://pharos.nih.gov/idg/api/v1/targets(8670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(8670)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(8670)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8670)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8670)/publications"},"_namespace":null},{"id":8671,"version":3,"created":1554920058000,"modified":1555038413000,"deprecated":false,"name":"Zinc finger protein GLI2","accession":"P10070","gene":"GLI2","description":"Isoform 5: Acts as a transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-2.582280920757344,"antibodyCount":196,"monoclonalCount":16,"pubmedCount":null,"jensenScore":355.02227,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":47.04986449514966,"pubTatorScore":3.368408682494858,"self":"https://pharos.nih.gov/idg/api/v1/targets(8671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(8671)/properties"},"_links":{"count":1154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8671)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8671)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(8671)/publications"},"_namespace":null},{"id":8672,"version":3,"created":1554920066000,"modified":1555038415000,"deprecated":false,"name":"POU domain, class 2, transcription factor 2","accession":"P09086","gene":"POU2F2","description":"Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4851414462287578,"antibodyCount":375,"monoclonalCount":62,"pubmedCount":null,"jensenScore":29.916443,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.11193015677682,"pubTatorScore":2.590230101799683,"self":"https://pharos.nih.gov/idg/api/v1/targets(8672)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(8672)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(8672)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8672)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8672)/publications"},"_namespace":null},{"id":8673,"version":3,"created":1554920072000,"modified":1555038417000,"deprecated":false,"name":"Transcriptional activator GLI3","accession":"P10071","gene":"GLI3","description":"Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.192959076844356,"antibodyCount":190,"monoclonalCount":29,"pubmedCount":null,"jensenScore":1388.807772,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":52.13344185067592,"pubTatorScore":2.356647862687158,"self":"https://pharos.nih.gov/idg/api/v1/targets(8673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(8673)/properties"},"_links":{"count":1244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8673)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(8673)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8673)/publications"},"_namespace":null},{"id":8674,"version":2,"created":1554920079000,"modified":1554920079000,"deprecated":false,"name":"Olfactory receptor 9I1","accession":"Q8NGQ6","gene":"OR9I1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":115,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.960076763921867,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8674)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8674)/properties"},"_links":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8674)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8674)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8674)/publications"},"_namespace":null},{"id":8675,"version":2,"created":1554920079000,"modified":1554920080000,"deprecated":false,"name":"Keratin-associated protein 10-2","accession":"P60368","gene":"KRTAP10-2","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.439289090983347,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8675)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8675)/properties"},"_links":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8675)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8675)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8675)/publications"},"_namespace":null},{"id":8676,"version":2,"created":1554920080000,"modified":1554920083000,"deprecated":false,"name":"Protein shisa-9","accession":"B4DS77","gene":"SHISA9","description":"Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8527386947744362,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.491411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.767436988467555,"pubTatorScore":0.23888200539695909,"self":"https://pharos.nih.gov/idg/api/v1/targets(8676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(8676)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(8676)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8676)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8676)/publications"},"_namespace":null},{"id":8677,"version":2,"created":1554920083000,"modified":1554920084000,"deprecated":false,"name":"Keratin-associated protein 10-3","accession":"P60369","gene":"KRTAP10-3","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.047619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.120624220408169,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(8677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8677)/properties"},"_links":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8677)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8677)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8677)/publications"},"_namespace":null},{"id":8678,"version":2,"created":1554920084000,"modified":1554920087000,"deprecated":false,"name":"Glycine dehydrogenase (decarboxylating), mitochondrial","accession":"P23378","gene":"GLDC","description":"The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7939246719320354,"antibodyCount":131,"monoclonalCount":0,"pubmedCount":null,"jensenScore":65.661897,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.972307802260964,"pubTatorScore":1.716549951647757,"self":"https://pharos.nih.gov/idg/api/v1/targets(8678)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(8678)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(8678)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8678)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(8678)/publications"},"_namespace":null},{"id":8679,"version":3,"created":1554920088000,"modified":1555038419000,"deprecated":false,"name":"Protein lin-9 homolog","accession":"Q5TKA1","gene":"LIN9","description":"Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.924906912702334,"antibodyCount":101,"monoclonalCount":2,"pubmedCount":null,"jensenScore":83.171359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":34.278233220034494,"pubTatorScore":1.8049175673163185,"self":"https://pharos.nih.gov/idg/api/v1/targets(8679)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(8679)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(8679)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8679)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8679)/publications"},"_namespace":null},{"id":8680,"version":2,"created":1554920092000,"modified":1554920092000,"deprecated":false,"name":"Olfactory receptor 10X1","accession":"Q8NGY0","gene":"OR10X1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":99,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.3127610825290486,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8680)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8680)/properties"},"_links":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8680)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8680)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8680)/publications"},"_namespace":null},{"id":8681,"version":2,"created":1554920092000,"modified":1554920093000,"deprecated":false,"name":"Olfactory receptor 6K3","accession":"Q8NGY3","gene":"OR6K3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.047619,"patentCount":110,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.51076555797979,"pubTatorScore":1.2214142378423387,"self":"https://pharos.nih.gov/idg/api/v1/targets(8681)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8681)/properties"},"_links":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(8681)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8681)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8681)/publications"},"_namespace":null},{"id":8682,"version":2,"created":1554920093000,"modified":1554920094000,"deprecated":false,"name":"Olfactory receptor 10Z1","accession":"Q8NGY1","gene":"OR10Z1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":83,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.047619,"patentCount":129,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.77665490207215,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8682)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8682)/properties"},"_links":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8682)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8682)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8682)/publications"},"_namespace":null},{"id":8683,"version":2,"created":1554920094000,"modified":1554920094000,"deprecated":false,"name":"Putative CNGA1-overlapping antisense gene protein","accession":"Q8IZM0","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8683)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8683)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8683)/links"},"_synonyms":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8683)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8683)/publications"},"_namespace":null},{"id":8684,"version":2,"created":1554920094000,"modified":1554920094000,"deprecated":false,"name":"Olfactory receptor 6K2","accession":"Q8NGY2","gene":"OR6K2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":128,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.416158279289783,"pubTatorScore":1.3837156283123464,"self":"https://pharos.nih.gov/idg/api/v1/targets(8684)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8684)/properties"},"_links":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8684)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8684)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8684)/publications"},"_namespace":null},{"id":8685,"version":2,"created":1554920095000,"modified":1554920095000,"deprecated":false,"name":"Putative olfactory receptor 10J6","accession":"Q8NGY7","gene":"OR10J6P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.505006722520489,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8685)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8685)/properties"},"_links":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8685)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8685)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8685)/publications"},"_namespace":null},{"id":8686,"version":2,"created":1554920095000,"modified":1554920095000,"deprecated":false,"name":"Olfactory receptor 6N1","accession":"Q8NGY5","gene":"OR6N1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":46,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":142,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.0829148321007,"pubTatorScore":1.6465670706149227,"self":"https://pharos.nih.gov/idg/api/v1/targets(8686)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8686)/properties"},"_links":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8686)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8686)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8686)/publications"},"_namespace":null},{"id":8687,"version":2,"created":1554920095000,"modified":1554920099000,"deprecated":false,"name":"Calcium-transporting ATPase type 2C member 2","accession":"O75185","gene":"ATP2C2","description":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.2274105364504642,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.537933,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.463689815065486,"pubTatorScore":1.197540891326669,"self":"https://pharos.nih.gov/idg/api/v1/targets(8687)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(8687)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(8687)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8687)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8687)/publications"},"_namespace":null},{"id":8688,"version":2,"created":1554920100000,"modified":1554920100000,"deprecated":false,"name":"Olfactory receptor 6N2","accession":"Q8NGY6","gene":"OR6N2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":72,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":159,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.095159475037216,"pubTatorScore":1.2671717518783905,"self":"https://pharos.nih.gov/idg/api/v1/targets(8688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8688)/properties"},"_links":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8688)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8688)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8688)/publications"},"_namespace":null},{"id":8689,"version":3,"created":1554920100000,"modified":1555038420000,"deprecated":false,"name":"Uncharacterized protein C1orf186","accession":"Q6ZWK4","gene":"RHEX","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8807253335018412,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.37005,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":0.0,"pubTatorScore":0.7484942517349062,"self":"https://pharos.nih.gov/idg/api/v1/targets(8689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(8689)/properties"},"_links":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(8689)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8689)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8689)/publications"},"_namespace":null},{"id":8690,"version":2,"created":1554920102000,"modified":1554920104000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 37","accession":"A1IGU5","gene":"ARHGEF37","description":"May act as a guanine nucleotide exchange factor (GEF).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.849053073434778,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(8690)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(8690)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8690)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8690)/publications"},"_namespace":null},{"id":8691,"version":2,"created":1554920105000,"modified":1554920107000,"deprecated":false,"name":"Xylulose kinase","accession":"O75191","gene":"XYLB","description":"Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.9729334895171435,"antibodyCount":74,"monoclonalCount":3,"pubmedCount":null,"jensenScore":93.099763,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.04445056146606,"pubTatorScore":1.0165027166545255,"self":"https://pharos.nih.gov/idg/api/v1/targets(8691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(8691)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(8691)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8691)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8691)/publications"},"_namespace":null},{"id":8692,"version":2,"created":1554920108000,"modified":1554920109000,"deprecated":false,"name":"Olfactory receptor 6Y1","accession":"Q8NGX8","gene":"OR6Y1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":141,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.145542310767832,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8692)/properties"},"_links":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8692)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8692)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8692)/publications"},"_namespace":null},{"id":8693,"version":3,"created":1554920109000,"modified":1555038421000,"deprecated":false,"name":"Peroxisomal membrane protein 11A","accession":"O75192","gene":"PEX11A","description":"May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670). May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7272635545797952,"antibodyCount":122,"monoclonalCount":8,"pubmedCount":null,"jensenScore":55.810899,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.333662434477294,"pubTatorScore":0.7671558660821804,"self":"https://pharos.nih.gov/idg/api/v1/targets(8693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(8693)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(8693)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8693)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8693)/publications"},"_namespace":null},{"id":8694,"version":2,"created":1554920112000,"modified":1554920113000,"deprecated":false,"name":"Olfactory receptor 6P1","accession":"Q8NGX9","gene":"OR6P1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":95,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.665226779361689,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8694)/properties"},"_links":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8694)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8694)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8694)/publications"},"_namespace":null},{"id":8695,"version":3,"created":1554920113000,"modified":1555038422000,"deprecated":false,"name":"Proline-, glutamic acid- and leucine-rich protein 1","accession":"Q8IZL8","gene":"PELP1","description":"Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.760966936479066,"antibodyCount":187,"monoclonalCount":36,"pubmedCount":null,"jensenScore":81.206367,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.14269764770014,"pubTatorScore":1.8633917409017053,"self":"https://pharos.nih.gov/idg/api/v1/targets(8695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(8695)/properties"},"_links":{"count":1147,"href":"https://pharos.nih.gov/idg/api/v1/targets(8695)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8695)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8695)/publications"},"_namespace":null},{"id":8696,"version":2,"created":1554920117000,"modified":1554920120000,"deprecated":false,"name":"Cyclin-dependent kinase 20","accession":"Q8IZL9","gene":"CDK20","description":"Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.8226869089709021,"antibodyCount":248,"monoclonalCount":43,"pubmedCount":null,"jensenScore":67.703621,"patentCount":26745,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.13501137930757,"pubTatorScore":2.5468903867137795,"self":"https://pharos.nih.gov/idg/api/v1/targets(8696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(8696)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8696)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8696)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8696)/publications"},"_namespace":null},{"id":8697,"version":3,"created":1554920121000,"modified":1555038423000,"deprecated":false,"name":"DnaJ homolog subfamily B member 6","accession":"O75190","gene":"DNAJB6","description":"Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.93302777386608,"antibodyCount":228,"monoclonalCount":48,"pubmedCount":null,"jensenScore":100.933552,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":45.50739514483805,"pubTatorScore":1.7320557874558458,"self":"https://pharos.nih.gov/idg/api/v1/targets(8697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(8697)/properties"},"_links":{"count":1178,"href":"https://pharos.nih.gov/idg/api/v1/targets(8697)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(8697)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8697)/publications"},"_namespace":null},{"id":8698,"version":2,"created":1554920126000,"modified":1554920127000,"deprecated":false,"name":"Transmembrane protease serine 11F","accession":"Q6ZWK6","gene":"TMPRSS11F","description":"Probable serine protease.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.9375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.720033711533683,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8698)/properties"},"_links":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(8698)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8698)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8698)/publications"},"_namespace":null},{"id":8699,"version":2,"created":1554920127000,"modified":1554920129000,"deprecated":false,"name":"Ribonuclease 4","accession":"P34096","gene":"RNASE4","description":"This RNase has marked specificity towards the 3' side of uridine nucleotides.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9920693704738005,"antibodyCount":56,"monoclonalCount":11,"pubmedCount":null,"jensenScore":6.713985,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.68098012751111,"pubTatorScore":1.1931245705150708,"self":"https://pharos.nih.gov/idg/api/v1/targets(8699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(8699)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(8699)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8699)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8699)/publications"},"_namespace":null},{"id":8700,"version":2,"created":1554920130000,"modified":1554920132000,"deprecated":false,"name":"Voltage-dependent calcium channel gamma-7 subunit","accession":"P62955","gene":"CACNG7","description":"Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.","idgFamily":"Ion Channel","idgTDL":"Tdark","novelty":-0.507620309121135,"antibodyCount":68,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.35609,"patentCount":193,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.470119910804748,"pubTatorScore":0.5289880060914519,"self":"https://pharos.nih.gov/idg/api/v1/targets(8700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(8700)/properties"},"_links":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(8700)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8700)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8700)/publications"},"_namespace":null},{"id":8701,"version":2,"created":1554920132000,"modified":1554920138000,"deprecated":false,"name":"Lysozyme C","accession":"P61626","gene":"LYZ","description":"Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.6694441909370044,"antibodyCount":533,"monoclonalCount":200,"pubmedCount":null,"jensenScore":4460.0782,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.78747055436798,"pubTatorScore":3.542920228323283,"self":"https://pharos.nih.gov/idg/api/v1/targets(8701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(8701)/properties"},"_links":{"count":1169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8701)/links"},"_synonyms":{"count":748,"href":"https://pharos.nih.gov/idg/api/v1/targets(8701)/synonyms"},"_publications":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8701)/publications"},"_namespace":null},{"id":8702,"version":2,"created":1554920139000,"modified":1554920142000,"deprecated":false,"name":"Bladder cancer-associated protein","accession":"P62952","gene":"BLCAP","description":"May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5372909190814839,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":35.046431,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.840868385905296,"pubTatorScore":1.3475352075760003,"self":"https://pharos.nih.gov/idg/api/v1/targets(8702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(8702)/properties"},"_links":{"count":859,"href":"https://pharos.nih.gov/idg/api/v1/targets(8702)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8702)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8702)/publications"},"_namespace":null},{"id":8703,"version":2,"created":1554920143000,"modified":1554920147000,"deprecated":false,"name":"Ran GTPase-activating protein 1","accession":"P46060","gene":"RANGAP1","description":"GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8407752042526508,"antibodyCount":254,"monoclonalCount":33,"pubmedCount":null,"jensenScore":65.66163,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.03820074181871,"pubTatorScore":1.8212698228002948,"self":"https://pharos.nih.gov/idg/api/v1/targets(8703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(8703)/properties"},"_links":{"count":1179,"href":"https://pharos.nih.gov/idg/api/v1/targets(8703)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8703)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8703)/publications"},"_namespace":null},{"id":8704,"version":2,"created":1554920148000,"modified":1554920152000,"deprecated":false,"name":"ATP-dependent DNA helicase Q1","accession":"P46063","gene":"RECQL","description":"DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.870529243379376,"antibodyCount":73,"monoclonalCount":14,"pubmedCount":null,"jensenScore":79.976003,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.39334768065526,"pubTatorScore":1.9168384263543665,"self":"https://pharos.nih.gov/idg/api/v1/targets(8704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(8704)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(8704)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8704)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8704)/publications"},"_namespace":null},{"id":8705,"version":2,"created":1554920153000,"modified":1554920156000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 17","accession":"O75179","gene":"ANKRD17","description":"Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2919129805089424,"antibodyCount":120,"monoclonalCount":44,"pubmedCount":null,"jensenScore":20.133727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.159072851269855,"pubTatorScore":0.8919177865757789,"self":"https://pharos.nih.gov/idg/api/v1/targets(8705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":427,"href":"https://pharos.nih.gov/idg/api/v1/targets(8705)/properties"},"_links":{"count":1089,"href":"https://pharos.nih.gov/idg/api/v1/targets(8705)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8705)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8705)/publications"},"_namespace":null},{"id":8706,"version":2,"created":1554920157000,"modified":1554920157000,"deprecated":false,"name":"Olfactory receptor 2T35","accession":"Q8NGX2","gene":"OR2T35","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":68,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":69,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.563014694646769,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8706)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8706)/properties"},"_links":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8706)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8706)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8706)/publications"},"_namespace":null},{"id":8707,"version":2,"created":1554920157000,"modified":1554920158000,"deprecated":false,"name":"Olfactory receptor 1S1","accession":"Q8NH92","gene":"OR1S1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":137,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.02378176738437,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8707)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8707)/properties"},"_links":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8707)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8707)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8707)/publications"},"_namespace":null},{"id":8708,"version":2,"created":1554920158000,"modified":1554920158000,"deprecated":false,"name":"Olfactory receptor 10T2","accession":"Q8NGX3","gene":"OR10T2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.0,"antibodyCount":70,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.0,"patentCount":397,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.41489060386926,"pubTatorScore":2.10286637122648,"self":"https://pharos.nih.gov/idg/api/v1/targets(8708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8708)/properties"},"_links":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8708)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8708)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8708)/publications"},"_namespace":null},{"id":8709,"version":2,"created":1554920158000,"modified":1554920159000,"deprecated":false,"name":"Olfactory receptor 1L3","accession":"Q8NH93","gene":"OR1L3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-0.14390657444343863,"antibodyCount":15,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.225491,"patentCount":150,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.52455373203381,"pubTatorScore":0.951823035315912,"self":"https://pharos.nih.gov/idg/api/v1/targets(8709)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8709)/properties"},"_links":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8709)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8709)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8709)/publications"},"_namespace":null},{"id":8710,"version":2,"created":1554920159000,"modified":1554920160000,"deprecated":false,"name":"Olfactory receptor 11L1","accession":"Q8NGX0","gene":"OR11L1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.22184875048494532,"antibodyCount":85,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.590909,"patentCount":128,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.861283904238523,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8710)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8710)/properties"},"_links":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8710)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8710)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8710)/publications"},"_namespace":null},{"id":8711,"version":2,"created":1554920160000,"modified":1554920163000,"deprecated":false,"name":"Calcium-responsive transactivator","accession":"O75177","gene":"SS18L1","description":"Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7778776442054025,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.299588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.48667905266785,"pubTatorScore":2.1246310059698827,"self":"https://pharos.nih.gov/idg/api/v1/targets(8711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(8711)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(8711)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8711)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8711)/publications"},"_namespace":null},{"id":8712,"version":2,"created":1554920164000,"modified":1554920164000,"deprecated":false,"name":"Olfactory receptor 5AK2","accession":"Q8NH90","gene":"OR5AK2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":80,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.030531204098594,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8712)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8712)/properties"},"_links":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8712)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8712)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8712)/publications"},"_namespace":null},{"id":8713,"version":2,"created":1554920164000,"modified":1554920165000,"deprecated":false,"name":"Olfactory receptor 2T34","accession":"Q8NGX1","gene":"OR2T34","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":180,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.024535217345029,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8713)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8713)/properties"},"_links":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8713)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8713)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8713)/publications"},"_namespace":null},{"id":8714,"version":2,"created":1554920165000,"modified":1554920165000,"deprecated":false,"name":"Olfactory receptor 10R2","accession":"Q8NGX6","gene":"OR10R2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.0,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":270,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.358917384890587,"pubTatorScore":2.344116127900097,"self":"https://pharos.nih.gov/idg/api/v1/targets(8714)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8714)/properties"},"_links":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8714)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8714)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8714)/publications"},"_namespace":null},{"id":8715,"version":3,"created":1554920165000,"modified":1555038425000,"deprecated":false,"name":"CCR4-NOT transcription complex subunit 3","accession":"O75175","gene":"CNOT3","description":"Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.780763992155254,"antibodyCount":190,"monoclonalCount":53,"pubmedCount":null,"jensenScore":546.715634,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":38.027002144665055,"pubTatorScore":1.1260469113877976,"self":"https://pharos.nih.gov/idg/api/v1/targets(8715)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(8715)/properties"},"_links":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(8715)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8715)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8715)/publications"},"_namespace":null},{"id":8716,"version":2,"created":1554920168000,"modified":1554920169000,"deprecated":false,"name":"Olfactory receptor 1L1","accession":"Q8NH94","gene":"OR1L1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-1.0,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.014900899084497,"pubTatorScore":0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(8716)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8716)/properties"},"_links":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8716)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8716)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8716)/publications"},"_namespace":null},{"id":8717,"version":4,"created":1554920169000,"modified":1555038427000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 4","accession":"O75173","gene":"ADAMTS4","description":"Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.6262267034983269,"antibodyCount":445,"monoclonalCount":71,"pubmedCount":null,"jensenScore":49.310029,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":30.571847264117412,"pubTatorScore":2.176002118203862,"self":"https://pharos.nih.gov/idg/api/v1/targets(8717)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(8717)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8717)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(8717)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8717)/publications"},"_namespace":null},{"id":8718,"version":3,"created":1554920204000,"modified":1555038429000,"deprecated":false,"name":"Mastermind-like protein 2","accession":"Q8IZL2","gene":"MAML2","description":"Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8285394686080834,"antibodyCount":136,"monoclonalCount":65,"pubmedCount":null,"jensenScore":72.442988,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":41.17521613304694,"pubTatorScore":1.8242887972473214,"self":"https://pharos.nih.gov/idg/api/v1/targets(8718)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(8718)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(8718)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8718)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8718)/publications"},"_namespace":null},{"id":8719,"version":2,"created":1554920209000,"modified":1554920209000,"deprecated":false,"name":"Olfactory receptor 10K1","accession":"Q8NGX5","gene":"OR10K1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.0,"antibodyCount":18,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.0,"patentCount":463,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.846405911274159,"pubTatorScore":2.237609555912661,"self":"https://pharos.nih.gov/idg/api/v1/targets(8719)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8719)/properties"},"_links":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8719)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8719)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8719)/publications"},"_namespace":null},{"id":8720,"version":2,"created":1554920209000,"modified":1554920212000,"deprecated":false,"name":"ATP synthase F(0) complex subunit C2, mitochondrial","accession":"Q06055","gene":"ATP5MC2","description":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0501326294676727,"antibodyCount":122,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.057907,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.08926025289588889,"self":"https://pharos.nih.gov/idg/api/v1/targets(8720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(8720)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8720)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8720)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8720)/publications"},"_namespace":null},{"id":8721,"version":2,"created":1554920213000,"modified":1554920213000,"deprecated":false,"name":"Putative olfactory receptor 13C6","accession":"Q8NH95","gene":"OR13C6P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8721)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8721)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8721)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8721)/publications"},"_namespace":null},{"id":8722,"version":2,"created":1554920213000,"modified":1554920216000,"deprecated":false,"name":"Paired amphipathic helix protein Sin3b","accession":"O75182","gene":"SIN3B","description":"Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3413096305422896,"antibodyCount":148,"monoclonalCount":9,"pubmedCount":null,"jensenScore":21.427611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.952392676579635,"pubTatorScore":1.251890038227617,"self":"https://pharos.nih.gov/idg/api/v1/targets(8722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(8722)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(8722)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8722)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8722)/publications"},"_namespace":null},{"id":8723,"version":2,"created":1554920217000,"modified":1554920218000,"deprecated":false,"name":"Putative olfactory receptor 5AK3","accession":"Q8NH89","gene":"OR5AK3P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.531665934139558,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8723)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8723)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8723)/synonyms"},"_publications":null,"_namespace":null},{"id":8724,"version":3,"created":1554920218000,"modified":1555038431000,"deprecated":false,"name":"Cytochrome P450 4V2","accession":"Q6ZWL3","gene":"CYP4V2","description":"Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7325185071127396,"antibodyCount":128,"monoclonalCount":19,"pubmedCount":null,"jensenScore":534.691006,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.49792866498531,"pubTatorScore":2.907066192265858,"self":"https://pharos.nih.gov/idg/api/v1/targets(8724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8724)/publications"},"_namespace":null},{"id":8725,"version":2,"created":1554920221000,"modified":1554920222000,"deprecated":false,"name":"Olfactory receptor 9G1","accession":"Q8NH87","gene":"OR9G1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":44,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":163,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.042794664382434,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/properties"},"_links":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8725)/publications"},"_namespace":null},{"id":8726,"version":3,"created":1554920222000,"modified":1555038433000,"deprecated":false,"name":"Mucolipin-2","accession":"Q8IZK6","gene":"MCOLN2","description":"Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.0689681909272863,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.804666,"patentCount":809,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":23.9148623732212,"pubTatorScore":0.9991603490540104,"self":"https://pharos.nih.gov/idg/api/v1/targets(8726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8726)/publications"},"_namespace":null},{"id":8727,"version":2,"created":1554920227000,"modified":1554920229000,"deprecated":false,"name":"Cytochrome c oxidase assembly protein COX19","accession":"Q49B96","gene":"COX19","description":"May be required for the assembly of mitochondrial cytochrome c oxidase.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.956612215296344,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.304503,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.326493807593366,"pubTatorScore":0.6897034526043669,"self":"https://pharos.nih.gov/idg/api/v1/targets(8727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8727)/publications"},"_namespace":null},{"id":8728,"version":3,"created":1554920230000,"modified":1555038435000,"deprecated":false,"name":"Solute carrier family 15 member 1","accession":"P46059","gene":"SLC15A1","description":"Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.749414119122246,"antibodyCount":183,"monoclonalCount":11,"pubmedCount":null,"jensenScore":568.631871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":64,"knowledgeAvailability":32.656797139443846,"pubTatorScore":2.5554877726688465,"self":"https://pharos.nih.gov/idg/api/v1/targets(8728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(8728)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(8728)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8728)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8728)/publications"},"_namespace":null},{"id":8729,"version":2,"created":1554920235000,"modified":1554920238000,"deprecated":false,"name":"T-complex protein 1 subunit theta","accession":"P50990","gene":"CCT8","description":"Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4952028935480806,"antibodyCount":212,"monoclonalCount":21,"pubmedCount":null,"jensenScore":31.81788,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.2343072963048,"pubTatorScore":1.2797682980126273,"self":"https://pharos.nih.gov/idg/api/v1/targets(8729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/properties"},"_links":{"count":1193,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8729)/publications"},"_namespace":null},{"id":8730,"version":2,"created":1554920239000,"modified":1554920243000,"deprecated":false,"name":"Alpha-(1,3)-fucosyltransferase 4","accession":"P22083","gene":"FUT4","description":"May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.112309573330625,"antibodyCount":1016,"monoclonalCount":891,"pubmedCount":null,"jensenScore":1234.949611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.234259576947004,"pubTatorScore":2.9371557189822957,"self":"https://pharos.nih.gov/idg/api/v1/targets(8730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8730)/publications"},"_namespace":null},{"id":8731,"version":2,"created":1554920244000,"modified":1554920248000,"deprecated":false,"name":"T-complex protein 1 subunit delta","accession":"P50991","gene":"CCT4","description":"Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7789192405167091,"antibodyCount":177,"monoclonalCount":33,"pubmedCount":null,"jensenScore":58.840048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.29289286467881,"pubTatorScore":2.5353169724476516,"self":"https://pharos.nih.gov/idg/api/v1/targets(8731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8731)/publications"},"_namespace":null},{"id":8732,"version":2,"created":1554920249000,"modified":1554920252000,"deprecated":false,"name":"Galactoside 2-alpha-L-fucosyltransferase 2","accession":"Q10981","gene":"FUT2","description":"Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.060615549346118,"antibodyCount":105,"monoclonalCount":38,"pubmedCount":null,"jensenScore":1122.915903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.93288727560294,"pubTatorScore":2.7225873871965582,"self":"https://pharos.nih.gov/idg/api/v1/targets(8732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(8732)/publications"},"_namespace":null},{"id":8733,"version":3,"created":1554920253000,"modified":1555038438000,"deprecated":false,"name":"rRNA 2'-O-methyltransferase fibrillarin","accession":"P22087","gene":"FBL","description":"S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.2733787293766614,"antibodyCount":248,"monoclonalCount":65,"pubmedCount":null,"jensenScore":1797.801806,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":42.256600205729654,"pubTatorScore":1.8796779487284707,"self":"https://pharos.nih.gov/idg/api/v1/targets(8733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8733)/publications"},"_namespace":null},{"id":8734,"version":2,"created":1554920258000,"modified":1554920259000,"deprecated":false,"name":"Olfactory receptor 6B3","accession":"Q8NGW1","gene":"OR6B3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":17,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.2,"patentCount":113,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.098320327421405,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/properties"},"_links":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8734)/publications"},"_namespace":null},{"id":8735,"version":2,"created":1554920259000,"modified":1554920260000,"deprecated":false,"name":"Olfactory receptor 10G6","accession":"Q8NH81","gene":"OR10G6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.089818941454712,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/properties"},"_links":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8735)/publications"},"_namespace":null},{"id":8736,"version":3,"created":1554920260000,"modified":1555038439000,"deprecated":false,"name":"Protein Jade-1","accession":"Q6IE81","gene":"JADE1","description":"Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.0335933580114582,"antibodyCount":135,"monoclonalCount":4,"pubmedCount":null,"jensenScore":13.270421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.959833753220465,"pubTatorScore":0.9968645681237569,"self":"https://pharos.nih.gov/idg/api/v1/targets(8736)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8736)/publications"},"_namespace":null},{"id":8737,"version":3,"created":1554920264000,"modified":1555038441000,"deprecated":false,"name":"Ret finger protein-like 4B","accession":"Q6ZWI9","gene":"RFPL4B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":8.103333623503636,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8737)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/properties"},"_links":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8737)/publications"},"_namespace":null},{"id":8738,"version":3,"created":1554920265000,"modified":1555038442000,"deprecated":false,"name":"Phosphatase and actin regulator 2","accession":"O75167","gene":"PHACTR2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.47952732803227915,"antibodyCount":83,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.67017846365449,"pubTatorScore":0.6197886888012714,"self":"https://pharos.nih.gov/idg/api/v1/targets(8738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8738)/publications"},"_namespace":null},{"id":8739,"version":3,"created":1554920270000,"modified":1555038444000,"deprecated":false,"name":"Nuclear receptor ROR-alpha","accession":"P35398","gene":"RORA","description":"Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling.","idgFamily":"Nuclear Receptor","idgTDL":"Tchem","novelty":-2.239613709291664,"antibodyCount":386,"monoclonalCount":60,"pubmedCount":null,"jensenScore":154.658388,"patentCount":36075,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":50.25323293808273,"pubTatorScore":2.1677284848923404,"self":"https://pharos.nih.gov/idg/api/v1/targets(8739)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":589,"href":"https://pharos.nih.gov/idg/api/v1/targets(8739)/properties"},"_links":{"count":1116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8739)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(8739)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(8739)/publications"},"_namespace":null},{"id":8740,"version":2,"created":1554920277000,"modified":1554920277000,"deprecated":false,"name":"Putative olfactory receptor 10D3","accession":"Q8NH80","gene":"OR10D3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":52,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.806771115229806,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8740)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8740)/properties"},"_links":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8740)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8740)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8740)/publications"},"_namespace":null},{"id":8741,"version":2,"created":1554920277000,"modified":1554920278000,"deprecated":false,"name":"Olfactory receptor 5R1","accession":"Q8NH85","gene":"OR5R1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":22,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.2,"patentCount":87,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.078216327177882,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8741)/properties"},"_links":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8741)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8741)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8741)/publications"},"_namespace":null},{"id":8742,"version":2,"created":1554920278000,"modified":1554920285000,"deprecated":false,"name":"Lysine-specific demethylase 4A","accession":"O75164","gene":"KDM4A","description":"Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-3.0615853587814117,"antibodyCount":271,"monoclonalCount":61,"pubmedCount":null,"jensenScore":1089.835801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.8159391945532,"pubTatorScore":1.9511279089883342,"self":"https://pharos.nih.gov/idg/api/v1/targets(8742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(8742)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(8742)/links"},"_synonyms":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(8742)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8742)/publications"},"_namespace":null},{"id":8743,"version":2,"created":1554920286000,"modified":1554920291000,"deprecated":false,"name":"DnaJ homolog subfamily C member 13","accession":"O75165","gene":"DNAJC13","description":"Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1245143198662644,"antibodyCount":28,"monoclonalCount":1,"pubmedCount":null,"jensenScore":16.442472,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.3541522786865,"pubTatorScore":1.246432151310096,"self":"https://pharos.nih.gov/idg/api/v1/targets(8743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(8743)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8743)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8743)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8743)/publications"},"_namespace":null},{"id":8744,"version":2,"created":1554920292000,"modified":1554920302000,"deprecated":false,"name":"Sodium/potassium-transporting ATPase subunit alpha-2","accession":"P50993","gene":"ATP1A2","description":"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.","idgFamily":"Transporter","idgTDL":"Tclin","novelty":-2.1247974691151206,"antibodyCount":116,"monoclonalCount":5,"pubmedCount":null,"jensenScore":136.21697,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.19768857345295,"pubTatorScore":2.15132606613026,"self":"https://pharos.nih.gov/idg/api/v1/targets(8744)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(8744)/properties"},"_links":{"count":1110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8744)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8744)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8744)/publications"},"_namespace":null},{"id":8745,"version":2,"created":1554920304000,"modified":1554920305000,"deprecated":false,"name":"Olfactory receptor 6K6","accession":"Q8NGW6","gene":"OR6K6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":130,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.502448109416486,"pubTatorScore":1.1563471604604356,"self":"https://pharos.nih.gov/idg/api/v1/targets(8745)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8745)/properties"},"_links":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8745)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8745)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8745)/publications"},"_namespace":null},{"id":8746,"version":2,"created":1554920305000,"modified":1554920305000,"deprecated":false,"name":"Olfactory receptor 4A5","accession":"Q8NH83","gene":"OR4A5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":141,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.386422176468362,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8746)/properties"},"_links":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8746)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8746)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8746)/publications"},"_namespace":null},{"id":8747,"version":3,"created":1554920305000,"modified":1555038446000,"deprecated":false,"name":"Annexin A11","accession":"P50995","gene":"ANXA11","description":"Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6829879686521227,"antibodyCount":203,"monoclonalCount":13,"pubmedCount":null,"jensenScore":54.029309,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.00352267107772,"pubTatorScore":1.655706575645496,"self":"https://pharos.nih.gov/idg/api/v1/targets(8747)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(8747)/properties"},"_links":{"count":1244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8747)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(8747)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8747)/publications"},"_namespace":null},{"id":8748,"version":2,"created":1554920310000,"modified":1554920311000,"deprecated":false,"name":"Olfactory receptor 6X1","accession":"Q8NH79","gene":"OR6X1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":1.146128035678238,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.066667,"patentCount":104,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.357312315584613,"pubTatorScore":-1.0791829832290267,"self":"https://pharos.nih.gov/idg/api/v1/targets(8748)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8748)/properties"},"_links":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8748)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8748)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8748)/publications"},"_namespace":null},{"id":8749,"version":2,"created":1554920311000,"modified":1554920313000,"deprecated":false,"name":"C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8","accession":"Q8IZJ3","gene":"CPAMD8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0770373792508803,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.957142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.072510665857383,"pubTatorScore":0.7621781993758471,"self":"https://pharos.nih.gov/idg/api/v1/targets(8749)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8749)/properties"},"_links":{"count":798,"href":"https://pharos.nih.gov/idg/api/v1/targets(8749)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8749)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8749)/publications"},"_namespace":null},{"id":8750,"version":3,"created":1554920314000,"modified":1555038447000,"deprecated":false,"name":"Ral-GDS-related protein","accession":"Q8IZJ4","gene":"RGL4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.20633658470797572,"antibodyCount":61,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.465842,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":18.161995248985367,"pubTatorScore":0.11579550501333502,"self":"https://pharos.nih.gov/idg/api/v1/targets(8750)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(8750)/properties"},"_links":{"count":765,"href":"https://pharos.nih.gov/idg/api/v1/targets(8750)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8750)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8750)/publications"},"_namespace":null},{"id":8751,"version":2,"created":1554920317000,"modified":1554920317000,"deprecated":false,"name":"Olfactory receptor 5H6","accession":"Q8NGV6","gene":"OR5H6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":172,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.801249694592298,"pubTatorScore":0.7468935307251721,"self":"https://pharos.nih.gov/idg/api/v1/targets(8751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8751)/properties"},"_links":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8751)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8751)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8751)/publications"},"_namespace":null},{"id":8752,"version":3,"created":1554920318000,"modified":1555038448000,"deprecated":false,"name":"Olfactory receptor 56B4","accession":"Q8NH76","gene":"OR56B4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":110,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":7.694441714906361,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8752)/properties"},"_links":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(8752)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8752)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8752)/publications"},"_namespace":null},{"id":8753,"version":3,"created":1554920319000,"modified":1555038450000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 6 regulatory subunit 2","accession":"O75170","gene":"PPP6R2","description":"Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.7211757747925625,"antibodyCount":43,"monoclonalCount":1,"pubmedCount":null,"jensenScore":50.338817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":33.731806889713454,"pubTatorScore":1.5379920483047969,"self":"https://pharos.nih.gov/idg/api/v1/targets(8753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(8753)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(8753)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8753)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8753)/publications"},"_namespace":null},{"id":8754,"version":2,"created":1554920322000,"modified":1554920323000,"deprecated":false,"name":"Olfactory receptor 5H2","accession":"Q8NGV7","gene":"OR5H2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":97,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.196516780156962,"pubTatorScore":0.8129133566428556,"self":"https://pharos.nih.gov/idg/api/v1/targets(8754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8754)/properties"},"_links":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8754)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8754)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8754)/publications"},"_namespace":null},{"id":8755,"version":2,"created":1554920323000,"modified":1554920323000,"deprecated":false,"name":"Inactive L-threonine 3-dehydrogenase, mitochondrial","accession":"Q8IZJ6","gene":"TDH","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.357539486152511,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(8755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8755)/properties"},"_links":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8755)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8755)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8755)/publications"},"_namespace":null},{"id":8756,"version":2,"created":1554920323000,"modified":1554920331000,"deprecated":false,"name":"Probable G-protein coupled receptor 139","accession":"Q6DWJ6","gene":"GPR139","description":"Orphan receptor. Seems to act through a G(q/11)-mediated pathway.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.171493744591665,"antibodyCount":96,"monoclonalCount":1,"pubmedCount":null,"jensenScore":15.306547,"patentCount":1735,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.009856527951214,"pubTatorScore":1.0138065583986664,"self":"https://pharos.nih.gov/idg/api/v1/targets(8756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8756)/properties"},"_links":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(8756)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8756)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8756)/publications"},"_namespace":null},{"id":8757,"version":2,"created":1554920332000,"modified":1554920334000,"deprecated":false,"name":"Lactoperoxidase","accession":"P22079","gene":"LPO","description":"Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7097048900900917,"antibodyCount":161,"monoclonalCount":2,"pubmedCount":null,"jensenScore":450.302784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.491884214692924,"pubTatorScore":2.668188751640584,"self":"https://pharos.nih.gov/idg/api/v1/targets(8757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8757)/properties"},"_links":{"count":579,"href":"https://pharos.nih.gov/idg/api/v1/targets(8757)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8757)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8757)/publications"},"_namespace":null},{"id":8758,"version":2,"created":1554920334000,"modified":1554920343000,"deprecated":false,"name":"Ubiquitin-40S ribosomal protein S27a","accession":"P62979","gene":"RPS27A","description":"40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6623071810427517,"antibodyCount":139,"monoclonalCount":38,"pubmedCount":null,"jensenScore":61.889498,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.34619200037948,"pubTatorScore":1.4582696378458881,"self":"https://pharos.nih.gov/idg/api/v1/targets(8758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(8758)/properties"},"_links":{"count":1213,"href":"https://pharos.nih.gov/idg/api/v1/targets(8758)/links"},"_synonyms":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(8758)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8758)/publications"},"_namespace":null},{"id":8759,"version":2,"created":1554920344000,"modified":1554920347000,"deprecated":false,"name":"Alpha-2,8-sialyltransferase 8F","accession":"P61647","gene":"ST8SIA6","description":"Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5077809310946386,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.442775,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.22453825657289,"pubTatorScore":0.5314789170422551,"self":"https://pharos.nih.gov/idg/api/v1/targets(8759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(8759)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(8759)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8759)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8759)/publications"},"_namespace":null},{"id":8760,"version":2,"created":1554920347000,"modified":1554920348000,"deprecated":false,"name":"Keratin-associated protein 12-4","accession":"P60329","gene":"KRTAP12-4","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.7117224756483385,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8760)/properties"},"_links":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8760)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8760)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8760)/publications"},"_namespace":null},{"id":8761,"version":2,"created":1554920348000,"modified":1554920351000,"deprecated":false,"name":"Suppressor of cytokine signaling 5","accession":"O75159","gene":"SOCS5","description":"SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.047399327957342,"antibodyCount":135,"monoclonalCount":13,"pubmedCount":null,"jensenScore":106.608757,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.878837617261325,"pubTatorScore":1.8556705508630413,"self":"https://pharos.nih.gov/idg/api/v1/targets(8761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8761)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(8761)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8761)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8761)/publications"},"_namespace":null},{"id":8762,"version":2,"created":1554920352000,"modified":1554920356000,"deprecated":false,"name":"TSC22 domain family protein 2","accession":"O75157","gene":"TSC22D2","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.0796118817932928,"antibodyCount":130,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.636616,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.94395046379394,"pubTatorScore":-0.46736153324238344,"self":"https://pharos.nih.gov/idg/api/v1/targets(8762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(8762)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(8762)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8762)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8762)/publications"},"_namespace":null},{"id":8763,"version":2,"created":1554920357000,"modified":1554920357000,"deprecated":false,"name":"Olfactory receptor 2Y1","accession":"Q8NGV0","gene":"OR2Y1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-0.4771212590626073,"antibodyCount":81,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.0,"patentCount":139,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.24066625084716,"pubTatorScore":1.5220092517545223,"self":"https://pharos.nih.gov/idg/api/v1/targets(8763)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8763)/properties"},"_links":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8763)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8763)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8763)/publications"},"_namespace":null},{"id":8764,"version":2,"created":1554920357000,"modified":1554920358000,"deprecated":false,"name":"Olfactory receptor 4A16","accession":"Q8NH70","gene":"OR4A16","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":122,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.555891669633222,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8764)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8764)/properties"},"_links":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(8764)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8764)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8764)/publications"},"_namespace":null},{"id":8765,"version":2,"created":1554920358000,"modified":1554920360000,"deprecated":false,"name":"Sestrin-2","accession":"P58004","gene":"SESN2","description":"Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8812916139337075,"antibodyCount":176,"monoclonalCount":43,"pubmedCount":null,"jensenScore":92.581422,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.89316876680651,"pubTatorScore":1.5917629920497853,"self":"https://pharos.nih.gov/idg/api/v1/targets(8765)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(8765)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(8765)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8765)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8765)/publications"},"_namespace":null},{"id":8766,"version":3,"created":1554920361000,"modified":1555038451000,"deprecated":false,"name":"N-acetylgalactosamine-6-sulfatase","accession":"P34059","gene":"GALNS","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4323197422536946,"antibodyCount":229,"monoclonalCount":2,"pubmedCount":null,"jensenScore":272.716698,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":37.668708382998915,"pubTatorScore":2.5605631598553056,"self":"https://pharos.nih.gov/idg/api/v1/targets(8766)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(8766)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(8766)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(8766)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8766)/publications"},"_namespace":null},{"id":8767,"version":3,"created":1554920367000,"modified":1555038452000,"deprecated":false,"name":"Sestrin-3","accession":"P58005","gene":"SESN3","description":"May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.219174579778592,"antibodyCount":148,"monoclonalCount":6,"pubmedCount":null,"jensenScore":15.477952,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.085777066888067,"pubTatorScore":1.0372525062381248,"self":"https://pharos.nih.gov/idg/api/v1/targets(8767)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(8767)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(8767)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8767)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8767)/publications"},"_namespace":null},{"id":8768,"version":2,"created":1554920371000,"modified":1554920375000,"deprecated":false,"name":"Cullin-associated NEDD8-dissociated protein 2","accession":"O75155","gene":"CAND2","description":"Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.62147673505855,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":386.658024,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.460798174765394,"pubTatorScore":1.7346799461673361,"self":"https://pharos.nih.gov/idg/api/v1/targets(8768)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(8768)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(8768)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8768)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8768)/publications"},"_namespace":null},{"id":8769,"version":2,"created":1554920375000,"modified":1554920376000,"deprecated":false,"name":"Kielin/chordin-like protein","accession":"Q6ZWJ8","gene":"KCP","description":"Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.500778697204648,"pubTatorScore":0.9208187365805955,"self":"https://pharos.nih.gov/idg/api/v1/targets(8769)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8769)/properties"},"_links":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8769)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8769)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8769)/publications"},"_namespace":null},{"id":8770,"version":2,"created":1554920376000,"modified":1554920379000,"deprecated":false,"name":"Clustered mitochondria protein homolog","accession":"O75153","gene":"CLUH","description":"mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8101204555539053,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.517857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.08536743168589,"pubTatorScore":0.7363964225895743,"self":"https://pharos.nih.gov/idg/api/v1/targets(8770)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(8770)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(8770)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8770)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8770)/publications"},"_namespace":null},{"id":8771,"version":3,"created":1554920379000,"modified":1555038454000,"deprecated":false,"name":"40S ribosomal protein S4, Y isoform 1","accession":"P22090","gene":"RPS4Y1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2576854042036083,"antibodyCount":139,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.295587,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.053400654093412,"pubTatorScore":1.878191117541408,"self":"https://pharos.nih.gov/idg/api/v1/targets(8771)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(8771)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(8771)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8771)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8771)/publications"},"_namespace":null},{"id":8772,"version":2,"created":1554920383000,"modified":1554920384000,"deprecated":false,"name":"Olfactory receptor 10A6","accession":"Q8NH74","gene":"OR10A6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":44,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":313,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.570377368646177,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8772)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8772)/properties"},"_links":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8772)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8772)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8772)/publications"},"_namespace":null},{"id":8773,"version":2,"created":1554920384000,"modified":1554920388000,"deprecated":false,"name":"Rab11 family-interacting protein 3","accession":"O75154","gene":"RAB11FIP3","description":"Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8909461628131148,"antibodyCount":68,"monoclonalCount":6,"pubmedCount":null,"jensenScore":6.61556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.08622006073775,"pubTatorScore":0.8456147290941879,"self":"https://pharos.nih.gov/idg/api/v1/targets(8773)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(8773)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(8773)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(8773)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8773)/publications"},"_namespace":null},{"id":8774,"version":2,"created":1554920389000,"modified":1554920389000,"deprecated":false,"name":"Olfactory receptor 13D1","accession":"Q8NGV5","gene":"OR13D1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":229,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.52862908494463,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8774)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8774)/properties"},"_links":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(8774)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8774)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8774)/publications"},"_namespace":null},{"id":8775,"version":2,"created":1554920389000,"modified":1554920390000,"deprecated":false,"name":"Olfactory receptor 4C6","accession":"Q8NH72","gene":"OR4C6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.17118392531766236,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.305556,"patentCount":109,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.669387341850314,"pubTatorScore":-0.48555452444347413,"self":"https://pharos.nih.gov/idg/api/v1/targets(8775)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8775)/properties"},"_links":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8775)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8775)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8775)/publications"},"_namespace":null},{"id":8776,"version":3,"created":1554920390000,"modified":1555038455000,"deprecated":false,"name":"Lysine-specific demethylase PHF2","accession":"O75151","gene":"PHF2","description":"Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.6946052032765135,"antibodyCount":74,"monoclonalCount":16,"pubmedCount":null,"jensenScore":5.135754,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.49480507784057,"pubTatorScore":1.1203629510334876,"self":"https://pharos.nih.gov/idg/api/v1/targets(8776)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(8776)/properties"},"_links":{"count":1055,"href":"https://pharos.nih.gov/idg/api/v1/targets(8776)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8776)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8776)/publications"},"_namespace":null},{"id":8777,"version":2,"created":1554920394000,"modified":1554920395000,"deprecated":false,"name":"Interferon lambda-2","accession":"Q8IZJ0","gene":"IFNL2","description":"Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5996463010804638,"antibodyCount":209,"monoclonalCount":71,"pubmedCount":null,"jensenScore":36.948972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.582440052426218,"pubTatorScore":1.0304454451474594,"self":"https://pharos.nih.gov/idg/api/v1/targets(8777)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(8777)/properties"},"_links":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(8777)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8777)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8777)/publications"},"_namespace":null},{"id":8778,"version":2,"created":1554920395000,"modified":1554920396000,"deprecated":false,"name":"Olfactory receptor 4S2","accession":"Q8NH73","gene":"OR4S2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.25,"patentCount":114,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.782102921102815,"pubTatorScore":0.09691001300805642,"self":"https://pharos.nih.gov/idg/api/v1/targets(8778)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8778)/properties"},"_links":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8778)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8778)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8778)/publications"},"_namespace":null},{"id":8779,"version":2,"created":1554920396000,"modified":1554920399000,"deprecated":false,"name":"Zinc finger CCCH domain-containing protein 11A","accession":"O75152","gene":"ZC3H11A","description":"Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2786924770032063,"antibodyCount":104,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.880711,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.31425166694538,"pubTatorScore":-0.09091970881126782,"self":"https://pharos.nih.gov/idg/api/v1/targets(8779)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(8779)/properties"},"_links":{"count":1074,"href":"https://pharos.nih.gov/idg/api/v1/targets(8779)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8779)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8779)/publications"},"_namespace":null},{"id":8780,"version":2,"created":1554920400000,"modified":1554920403000,"deprecated":false,"name":"Inter-alpha-trypsin inhibitor heavy chain H3","accession":"Q06033","gene":"ITIH3","description":"May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1479452985565286,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.513225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.780098810443207,"pubTatorScore":1.1848811448397276,"self":"https://pharos.nih.gov/idg/api/v1/targets(8780)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(8780)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(8780)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8780)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8780)/publications"},"_namespace":null},{"id":8781,"version":3,"created":1554920403000,"modified":1555038456000,"deprecated":false,"name":"Netrin receptor UNC5B","accession":"Q8IZJ1","gene":"UNC5B","description":"Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.723096772621264,"antibodyCount":115,"monoclonalCount":14,"pubmedCount":null,"jensenScore":48.34966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.009247371230565,"pubTatorScore":1.564298107144816,"self":"https://pharos.nih.gov/idg/api/v1/targets(8781)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(8781)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(8781)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8781)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8781)/publications"},"_namespace":null},{"id":8782,"version":2,"created":1554920407000,"modified":1554920408000,"deprecated":false,"name":"Olfactory receptor 52I2","accession":"Q8NH67","gene":"OR52I2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":120,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.856813384487461,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8782)/properties"},"_links":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8782)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8782)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8782)/publications"},"_namespace":null},{"id":8783,"version":3,"created":1554920408000,"modified":1555038457000,"deprecated":false,"name":"Nephrocystin-4","accession":"O75161","gene":"NPHP4","description":"Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4145561913853593,"antibodyCount":54,"monoclonalCount":6,"pubmedCount":null,"jensenScore":27.146158,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.53903068936459,"pubTatorScore":1.4404087416294826,"self":"https://pharos.nih.gov/idg/api/v1/targets(8783)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(8783)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(8783)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(8783)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8783)/publications"},"_namespace":null},{"id":8784,"version":3,"created":1554920412000,"modified":1555038459000,"deprecated":false,"name":"Syntaxin-binding protein 4","accession":"Q6ZWJ1","gene":"STXBP4","description":"Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8328103134079698,"antibodyCount":67,"monoclonalCount":17,"pubmedCount":null,"jensenScore":7.989178,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":34.65158761735015,"pubTatorScore":0.810569738387301,"self":"https://pharos.nih.gov/idg/api/v1/targets(8784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(8784)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(8784)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8784)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8784)/publications"},"_namespace":null},{"id":8785,"version":2,"created":1554920416000,"modified":1554920418000,"deprecated":false,"name":"Probable G-protein coupled receptor 150","accession":"Q8NGU9","gene":"GPR150","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":0.34003465187757503,"antibodyCount":122,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.435324,"patentCount":466,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.154612082592582,"pubTatorScore":-0.16739018941506228,"self":"https://pharos.nih.gov/idg/api/v1/targets(8785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(8785)/properties"},"_links":{"count":731,"href":"https://pharos.nih.gov/idg/api/v1/targets(8785)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8785)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8785)/publications"},"_namespace":null},{"id":8786,"version":3,"created":1554920418000,"modified":1555038460000,"deprecated":false,"name":"Forkhead box protein L2","accession":"P58012","gene":"FOXL2","description":"Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.8155726323654036,"antibodyCount":234,"monoclonalCount":11,"pubmedCount":null,"jensenScore":652.10831,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.994204416499436,"pubTatorScore":2.6596085450588873,"self":"https://pharos.nih.gov/idg/api/v1/targets(8786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(8786)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(8786)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8786)/synonyms"},"_publications":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(8786)/publications"},"_namespace":null},{"id":8787,"version":2,"created":1554920422000,"modified":1554920423000,"deprecated":false,"name":"Olfactory receptor 5W2","accession":"Q8NH69","gene":"OR5W2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":98,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.333821566136967,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8787)/properties"},"_links":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8787)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8787)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8787)/publications"},"_namespace":null},{"id":8788,"version":2,"created":1554920423000,"modified":1554920426000,"deprecated":false,"name":"Ubiquitin-60S ribosomal protein L40","accession":"P62987","gene":"UBA52","description":"60S ribosomal protein L40: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1253448470025553,"antibodyCount":181,"monoclonalCount":64,"pubmedCount":null,"jensenScore":131.352401,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.28355855467741,"pubTatorScore":1.451645412711796,"self":"https://pharos.nih.gov/idg/api/v1/targets(8788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(8788)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(8788)/links"},"_synonyms":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(8788)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8788)/publications"},"_namespace":null},{"id":8789,"version":3,"created":1554920428000,"modified":1555038461000,"deprecated":false,"name":"Interferon lambda-3","accession":"Q8IZI9","gene":"IFNL3","description":"Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0947709604546985,"antibodyCount":228,"monoclonalCount":77,"pubmedCount":null,"jensenScore":1258.990524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":13.131449273044051,"pubTatorScore":3.0488721004496075,"self":"https://pharos.nih.gov/idg/api/v1/targets(8789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":616,"href":"https://pharos.nih.gov/idg/api/v1/targets(8789)/properties"},"_links":{"count":736,"href":"https://pharos.nih.gov/idg/api/v1/targets(8789)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8789)/synonyms"},"_publications":{"count":497,"href":"https://pharos.nih.gov/idg/api/v1/targets(8789)/publications"},"_namespace":null},{"id":8790,"version":2,"created":1554920431000,"modified":1554920433000,"deprecated":false,"name":"Nanos homolog 3","accession":"P60323","gene":"NANOS3","description":"Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6028808883627463,"antibodyCount":90,"monoclonalCount":5,"pubmedCount":null,"jensenScore":41.17447,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.138444125097156,"pubTatorScore":1.0031952643534807,"self":"https://pharos.nih.gov/idg/api/v1/targets(8790)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(8790)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(8790)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8790)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8790)/publications"},"_namespace":null},{"id":8791,"version":3,"created":1554920434000,"modified":1555038464000,"deprecated":false,"name":"Nanos homolog 2","accession":"P60321","gene":"NANOS2","description":"Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5790119245995733,"antibodyCount":196,"monoclonalCount":7,"pubmedCount":null,"jensenScore":37.256595,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":15.658418686538727,"pubTatorScore":0.9192026594690109,"self":"https://pharos.nih.gov/idg/api/v1/targets(8791)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(8791)/properties"},"_links":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(8791)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8791)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8791)/publications"},"_namespace":null},{"id":8792,"version":2,"created":1554920436000,"modified":1554920436000,"deprecated":false,"name":"Keratin-associated protein 12-3","accession":"P60328","gene":"KRTAP12-3","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.2304489213782739,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.010233603504174,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8792)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8792)/properties"},"_links":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8792)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8792)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8792)/publications"},"_namespace":null},{"id":8793,"version":3,"created":1554920436000,"modified":1555038465000,"deprecated":false,"name":"60S ribosomal protein L8","accession":"P62917","gene":"RPL8","description":"Component of the large ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6280710559901592,"antibodyCount":222,"monoclonalCount":4,"pubmedCount":null,"jensenScore":41.558266,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":42.95003017190894,"pubTatorScore":0.9522028162285077,"self":"https://pharos.nih.gov/idg/api/v1/targets(8793)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(8793)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(8793)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(8793)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8793)/publications"},"_namespace":null},{"id":8794,"version":3,"created":1554920440000,"modified":1555038466000,"deprecated":false,"name":"CD59 glycoprotein","accession":"P13987","gene":"CD59","description":"The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.269371126797651,"antibodyCount":1039,"monoclonalCount":772,"pubmedCount":null,"jensenScore":1829.919239,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.6172727059774,"pubTatorScore":4.242322318252463,"self":"https://pharos.nih.gov/idg/api/v1/targets(8794)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":630,"href":"https://pharos.nih.gov/idg/api/v1/targets(8794)/properties"},"_links":{"count":1532,"href":"https://pharos.nih.gov/idg/api/v1/targets(8794)/links"},"_synonyms":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(8794)/synonyms"},"_publications":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(8794)/publications"},"_namespace":null},{"id":8795,"version":2,"created":1554920446000,"modified":1554920446000,"deprecated":false,"name":"Putative HTLV-1-related endogenous sequence","accession":"P13985","gene":"HRES1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.5604569624567968,"pubTatorScore":1.0606978403536116,"self":"https://pharos.nih.gov/idg/api/v1/targets(8795)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8795)/properties"},"_links":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8795)/links"},"_synonyms":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8795)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8795)/publications"},"_namespace":null},{"id":8796,"version":2,"created":1554920446000,"modified":1554920450000,"deprecated":false,"name":"General transcription factor IIF subunit 2","accession":"P13984","gene":"GTF2F2","description":"TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5506359363629976,"antibodyCount":192,"monoclonalCount":8,"pubmedCount":null,"jensenScore":36.172007,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.86838976353104,"pubTatorScore":1.615267231162574,"self":"https://pharos.nih.gov/idg/api/v1/targets(8796)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(8796)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(8796)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(8796)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8796)/publications"},"_namespace":null},{"id":8797,"version":2,"created":1554920451000,"modified":1554920453000,"deprecated":false,"name":"Small integral membrane protein 24","accession":"O75264","gene":"SMIM24","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.46928708264248,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8797)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(8797)/properties"},"_links":{"count":733,"href":"https://pharos.nih.gov/idg/api/v1/targets(8797)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8797)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8797)/publications"},"_namespace":null},{"id":8798,"version":3,"created":1554920453000,"modified":1555038469000,"deprecated":false,"name":"SprT-like domain-containing protein Spartan","accession":"Q9H040","gene":"SPRTN","description":"Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2017417086263613,"antibodyCount":72,"monoclonalCount":2,"pubmedCount":null,"jensenScore":155.678978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":25.113538286513318,"pubTatorScore":1.1175474324007602,"self":"https://pharos.nih.gov/idg/api/v1/targets(8798)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(8798)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(8798)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8798)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8798)/publications"},"_namespace":null},{"id":8799,"version":3,"created":1554920457000,"modified":1555038470000,"deprecated":false,"name":"Zinc finger protein 549","accession":"Q6P9A3","gene":"ZNF549","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":29,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.74910958345772,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(8799)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(8799)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8799)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8799)/publications"},"_namespace":null},{"id":8800,"version":2,"created":1554920460000,"modified":1554920463000,"deprecated":false,"name":"60S ribosomal protein L32","accession":"P62910","gene":"RPL32","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.224632795887148,"antibodyCount":71,"monoclonalCount":27,"pubmedCount":null,"jensenScore":143.339644,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.08109036057725,"pubTatorScore":1.9640808536405874,"self":"https://pharos.nih.gov/idg/api/v1/targets(8800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(8800)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(8800)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8800)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8800)/publications"},"_namespace":null},{"id":8801,"version":2,"created":1554920463000,"modified":1554920468000,"deprecated":false,"name":"U1 small nuclear ribonucleoprotein A","accession":"P09012","gene":"SNRPA","description":"Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.090005618811662,"antibodyCount":250,"monoclonalCount":54,"pubmedCount":null,"jensenScore":1171.250911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.419289390309366,"pubTatorScore":2.2509636815742806,"self":"https://pharos.nih.gov/idg/api/v1/targets(8801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(8801)/properties"},"_links":{"count":1185,"href":"https://pharos.nih.gov/idg/api/v1/targets(8801)/links"},"_synonyms":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(8801)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8801)/publications"},"_namespace":null},{"id":8802,"version":3,"created":1554920469000,"modified":1555038473000,"deprecated":false,"name":"60S ribosomal protein L11","accession":"P62913","gene":"RPL11","description":"Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2354936005163397,"antibodyCount":237,"monoclonalCount":35,"pubmedCount":null,"jensenScore":158.948726,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":66,"knowledgeAvailability":41.34085859886552,"pubTatorScore":1.8612991530924368,"self":"https://pharos.nih.gov/idg/api/v1/targets(8802)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(8802)/properties"},"_links":{"count":1197,"href":"https://pharos.nih.gov/idg/api/v1/targets(8802)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8802)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8802)/publications"},"_namespace":null},{"id":8803,"version":3,"created":1554920474000,"modified":1555038474000,"deprecated":false,"name":"Homeobox protein Hox-D4","accession":"P09016","gene":"HOXD4","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7058160467374228,"antibodyCount":143,"monoclonalCount":50,"pubmedCount":null,"jensenScore":47.585198,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":20.961762012528634,"pubTatorScore":1.3856075425227223,"self":"https://pharos.nih.gov/idg/api/v1/targets(8803)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(8803)/properties"},"_links":{"count":617,"href":"https://pharos.nih.gov/idg/api/v1/targets(8803)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(8803)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8803)/publications"},"_namespace":null},{"id":8804,"version":3,"created":1554920476000,"modified":1555038478000,"deprecated":false,"name":"NF-kappa-B inhibitor alpha","accession":"P25963","gene":"NFKBIA","description":"Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.349867395772987,"antibodyCount":1300,"monoclonalCount":360,"pubmedCount":null,"jensenScore":1979.773392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":60.541495941500244,"pubTatorScore":3.185672011585722,"self":"https://pharos.nih.gov/idg/api/v1/targets(8804)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(8804)/properties"},"_links":{"count":1372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8804)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8804)/synonyms"},"_publications":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(8804)/publications"},"_namespace":null},{"id":8805,"version":3,"created":1554920485000,"modified":1555038481000,"deprecated":false,"name":"Homeobox protein Hox-C4","accession":"P09017","gene":"HOXC4","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4036005258318502,"antibodyCount":209,"monoclonalCount":54,"pubmedCount":null,"jensenScore":26.323733,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":32.55892106179868,"pubTatorScore":1.2438653976535263,"self":"https://pharos.nih.gov/idg/api/v1/targets(8805)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(8805)/properties"},"_links":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(8805)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8805)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(8805)/publications"},"_namespace":null},{"id":8806,"version":2,"created":1554920488000,"modified":1554920488000,"deprecated":false,"name":"Putative 40S ribosomal protein S26-like 1","accession":"Q5JNZ5","gene":"RPS26P11","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.287948269299833,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8806)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8806)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(8806)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8806)/publications"},"_namespace":null},{"id":8807,"version":3,"created":1554920488000,"modified":1555038482000,"deprecated":false,"name":"Zinc finger protein 311","accession":"Q5JNZ3","gene":"ZNF311","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.19349402717397773,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.382576,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":18.517343969029795,"pubTatorScore":-0.3298868682954773,"self":"https://pharos.nih.gov/idg/api/v1/targets(8807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(8807)/properties"},"_links":{"count":707,"href":"https://pharos.nih.gov/idg/api/v1/targets(8807)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(8807)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8807)/publications"},"_namespace":null},{"id":8808,"version":3,"created":1554920491000,"modified":1555038483000,"deprecated":false,"name":"Coiled-coil domain-containing protein 130","accession":"P13994","gene":"CCDC130","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.102203621833684,"antibodyCount":46,"monoclonalCount":2,"pubmedCount":null,"jensenScore":116.515992,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":30.66377149615588,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(8808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(8808)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(8808)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8808)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8808)/publications"},"_namespace":null},{"id":8809,"version":3,"created":1554920494000,"modified":1555038484000,"deprecated":false,"name":"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","accession":"P13995","gene":"MTHFD2","description":"Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.4308899078211155,"antibodyCount":131,"monoclonalCount":26,"pubmedCount":null,"jensenScore":24.91429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.70939013745811,"pubTatorScore":1.18536675852488,"self":"https://pharos.nih.gov/idg/api/v1/targets(8809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(8809)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(8809)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8809)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8809)/publications"},"_namespace":null},{"id":8810,"version":3,"created":1554920499000,"modified":1555038487000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial","accession":"O75251","gene":"NDUFS7","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.9324939511538095,"antibodyCount":94,"monoclonalCount":6,"pubmedCount":null,"jensenScore":793.421427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":59,"knowledgeAvailability":40.97852976721146,"pubTatorScore":2.130716297059536,"self":"https://pharos.nih.gov/idg/api/v1/targets(8810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(8810)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(8810)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8810)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8810)/publications"},"_namespace":null},{"id":8811,"version":3,"created":1554920505000,"modified":1555038488000,"deprecated":false,"name":"Olfactory receptor 2T2","accession":"Q6IF00","gene":"OR2T2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":1.0,"antibodyCount":25,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.125,"patentCount":91,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":7.619591236530255,"pubTatorScore":1.0211892577085568,"self":"https://pharos.nih.gov/idg/api/v1/targets(8811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8811)/properties"},"_links":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8811)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8811)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8811)/publications"},"_namespace":null},{"id":8812,"version":2,"created":1554920506000,"modified":1554920509000,"deprecated":false,"name":"Integrator complex subunit 5","accession":"Q6P9B9","gene":"INTS5","description":"Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.2076600086315257,"antibodyCount":49,"monoclonalCount":3,"pubmedCount":null,"jensenScore":15.630525,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.67719198098731,"pubTatorScore":0.9075904703095689,"self":"https://pharos.nih.gov/idg/api/v1/targets(8812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(8812)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(8812)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8812)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8812)/publications"},"_namespace":null},{"id":8813,"version":3,"created":1554920510000,"modified":1555038488000,"deprecated":false,"name":"TLD domain-containing protein 1","accession":"Q6P9B6","gene":"TLDC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":130,"monoclonalCount":61,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.723504018259,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(8813)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(8813)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8813)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8813)/publications"},"_namespace":null},{"id":8814,"version":2,"created":1554920513000,"modified":1554920514000,"deprecated":false,"name":"Putative trypsin-6","accession":"Q8NHM4","gene":"PRSS3P2","description":"May regulate cell migration.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-2.501021284825846,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":549.446646,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.836927509512824,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(8814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8814)/properties"},"_links":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8814)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(8814)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8814)/publications"},"_namespace":null},{"id":8815,"version":2,"created":1554920514000,"modified":1554920519000,"deprecated":false,"name":"Lysine-specific demethylase 2B","accession":"Q8NHM5","gene":"KDM2B","description":"Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.5632837815955127,"antibodyCount":248,"monoclonalCount":58,"pubmedCount":null,"jensenScore":41.729966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.31805352730072,"pubTatorScore":1.3583994649101774,"self":"https://pharos.nih.gov/idg/api/v1/targets(8815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(8815)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(8815)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8815)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(8815)/publications"},"_namespace":null},{"id":8816,"version":4,"created":1554920519000,"modified":1555038489000,"deprecated":false,"name":"Serine/threonine-protein kinase pim-1","accession":"P11309","gene":"PIM1","description":"Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.8767888440059095,"antibodyCount":531,"monoclonalCount":197,"pubmedCount":null,"jensenScore":758.755825,"patentCount":56710,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":50.38556025477465,"pubTatorScore":2.676971035170778,"self":"https://pharos.nih.gov/idg/api/v1/targets(8816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(8816)/properties"},"_links":{"count":2224,"href":"https://pharos.nih.gov/idg/api/v1/targets(8816)/links"},"_synonyms":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(8816)/synonyms"},"_publications":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8816)/publications"},"_namespace":null},{"id":8817,"version":3,"created":1554920753000,"modified":1555038494000,"deprecated":false,"name":"DnaJ homolog subfamily C member 14","accession":"Q6Y2X3","gene":"DNAJC14","description":"Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1564268983142563,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.789189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.973813124979166,"pubTatorScore":1.6590177452721755,"self":"https://pharos.nih.gov/idg/api/v1/targets(8817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(8817)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(8817)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8817)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8817)/publications"},"_namespace":null},{"id":8818,"version":3,"created":1554920757000,"modified":1554920799000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase A","accession":"P62937","gene":"PPIA","description":"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.9782155051102186,"antibodyCount":436,"monoclonalCount":104,"pubmedCount":null,"jensenScore":870.712445,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.44558294728798,"pubTatorScore":2.7147951209663694,"self":"https://pharos.nih.gov/idg/api/v1/targets(8818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":618,"href":"https://pharos.nih.gov/idg/api/v1/targets(8818)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(8818)/links"},"_synonyms":{"count":557,"href":"https://pharos.nih.gov/idg/api/v1/targets(8818)/synonyms"},"_publications":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(8818)/publications"},"_namespace":null},{"id":8819,"version":2,"created":1554920801000,"modified":1554920806000,"deprecated":false,"name":"Transcriptional regulator ERG","accession":"P11308","gene":"ERG","description":"Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-1.1911092772010727,"antibodyCount":398,"monoclonalCount":146,"pubmedCount":null,"jensenScore":12.306199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.962478777122406,"pubTatorScore":3.3127720833842265,"self":"https://pharos.nih.gov/idg/api/v1/targets(8819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":708,"href":"https://pharos.nih.gov/idg/api/v1/targets(8819)/properties"},"_links":{"count":1287,"href":"https://pharos.nih.gov/idg/api/v1/targets(8819)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(8819)/synonyms"},"_publications":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(8819)/publications"},"_namespace":null},{"id":8820,"version":2,"created":1554920808000,"modified":1554920808000,"deprecated":false,"name":"Putative protein FAM74A3","accession":"Q4VXF1","gene":"FAM74A3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.074210322565987,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8820)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8820)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8820)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8820)/publications"},"_namespace":null},{"id":8821,"version":2,"created":1554920808000,"modified":1554920814000,"deprecated":false,"name":"Cyclin-dependent kinase inhibitor 1C","accession":"P49918","gene":"CDKN1C","description":"Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.8119916767242463,"antibodyCount":665,"monoclonalCount":313,"pubmedCount":null,"jensenScore":631.032602,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.85250187981165,"pubTatorScore":2.672241354692281,"self":"https://pharos.nih.gov/idg/api/v1/targets(8821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(8821)/properties"},"_links":{"count":1135,"href":"https://pharos.nih.gov/idg/api/v1/targets(8821)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8821)/synonyms"},"_publications":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(8821)/publications"},"_namespace":null},{"id":8822,"version":2,"created":1554920815000,"modified":1554920820000,"deprecated":false,"name":"DNA ligase 4","accession":"P49917","gene":"LIG4","description":"Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.149091674610175,"antibodyCount":204,"monoclonalCount":15,"pubmedCount":null,"jensenScore":140.8936,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.02789033822595,"pubTatorScore":2.3911721107162194,"self":"https://pharos.nih.gov/idg/api/v1/targets(8822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(8822)/properties"},"_links":{"count":1308,"href":"https://pharos.nih.gov/idg/api/v1/targets(8822)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8822)/synonyms"},"_publications":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8822)/publications"},"_namespace":null},{"id":8823,"version":3,"created":1554920822000,"modified":1555038495000,"deprecated":false,"name":"DNA ligase 3","accession":"P49916","gene":"LIG3","description":"Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.751438258640426,"antibodyCount":239,"monoclonalCount":50,"pubmedCount":null,"jensenScore":531.141853,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":51.23795541088211,"pubTatorScore":1.8728400249249904,"self":"https://pharos.nih.gov/idg/api/v1/targets(8823)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":507,"href":"https://pharos.nih.gov/idg/api/v1/targets(8823)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8823)/links"},"_synonyms":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(8823)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8823)/publications"},"_namespace":null},{"id":8824,"version":2,"created":1554920827000,"modified":1554920830000,"deprecated":false,"name":"GMP synthase [glutamine-hydrolyzing]","accession":"P49915","gene":"GMPS","description":"Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4848987750935323,"antibodyCount":194,"monoclonalCount":51,"pubmedCount":null,"jensenScore":295.064995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.30846374411108,"pubTatorScore":1.8211026343085956,"self":"https://pharos.nih.gov/idg/api/v1/targets(8824)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(8824)/properties"},"_links":{"count":962,"href":"https://pharos.nih.gov/idg/api/v1/targets(8824)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8824)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8824)/publications"},"_namespace":null},{"id":8825,"version":2,"created":1554920831000,"modified":1554920839000,"deprecated":false,"name":"Anoctamin-1","accession":"Q5XXA6","gene":"ANO1","description":"Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.5867371273643602,"antibodyCount":565,"monoclonalCount":319,"pubmedCount":null,"jensenScore":414.3942,"patentCount":6833,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.88668207296256,"pubTatorScore":2.368166000298569,"self":"https://pharos.nih.gov/idg/api/v1/targets(8825)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(8825)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(8825)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8825)/synonyms"},"_publications":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(8825)/publications"},"_namespace":null},{"id":8826,"version":2,"created":1554920840000,"modified":1554920842000,"deprecated":false,"name":"Coiled-coil domain-containing glutamate-rich protein 2","accession":"I3L3R5","gene":"CCER2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.887912927547078,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(8826)/properties"},"_links":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(8826)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8826)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8826)/publications"},"_namespace":null},{"id":8827,"version":2,"created":1554920842000,"modified":1554920845000,"deprecated":false,"name":"Zinc finger protein 165","accession":"P49910","gene":"ZNF165","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0035128013796724,"antibodyCount":140,"monoclonalCount":26,"pubmedCount":null,"jensenScore":9.993867,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.77868591713683,"pubTatorScore":0.9695194410367058,"self":"https://pharos.nih.gov/idg/api/v1/targets(8827)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(8827)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(8827)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(8827)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8827)/publications"},"_namespace":null},{"id":8828,"version":2,"created":1554920846000,"modified":1554920849000,"deprecated":false,"name":"Leukocyte immunoglobulin-like receptor subfamily B member 1","accession":"Q8NHL6","gene":"LILRB1","description":"Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.224865971790658,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":181.686576,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.495262477395276,"pubTatorScore":2.36875143560803,"self":"https://pharos.nih.gov/idg/api/v1/targets(8828)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(8828)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(8828)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(8828)/synonyms"},"_publications":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8828)/publications"},"_namespace":null},{"id":8829,"version":2,"created":1554920850000,"modified":1554920857000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 5","accession":"P25942","gene":"CD40","description":"Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.5003953861887376,"antibodyCount":1879,"monoclonalCount":1227,"pubmedCount":null,"jensenScore":3120.263117,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.18165609130406,"pubTatorScore":3.377040933430609,"self":"https://pharos.nih.gov/idg/api/v1/targets(8829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(8829)/properties"},"_links":{"count":1408,"href":"https://pharos.nih.gov/idg/api/v1/targets(8829)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(8829)/synonyms"},"_publications":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(8829)/publications"},"_namespace":null},{"id":8830,"version":3,"created":1554920859000,"modified":1555038497000,"deprecated":false,"name":"5-formyltetrahydrofolate cyclo-ligase","accession":"P49914","gene":"MTHFS","description":"Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1009446169561838,"antibodyCount":167,"monoclonalCount":22,"pubmedCount":null,"jensenScore":12.818254,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.622390426687666,"pubTatorScore":1.2530551613601613,"self":"https://pharos.nih.gov/idg/api/v1/targets(8830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8830)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(8830)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8830)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8830)/publications"},"_namespace":null},{"id":8831,"version":2,"created":1554920863000,"modified":1554920866000,"deprecated":false,"name":"10 kDa heat shock protein, mitochondrial","accession":"P61604","gene":"HSPE1","description":"Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0356602142668727,"antibodyCount":403,"monoclonalCount":57,"pubmedCount":null,"jensenScore":1027.823084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.27400680332218,"pubTatorScore":2.647238225185492,"self":"https://pharos.nih.gov/idg/api/v1/targets(8831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(8831)/properties"},"_links":{"count":1170,"href":"https://pharos.nih.gov/idg/api/v1/targets(8831)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8831)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8831)/publications"},"_namespace":null},{"id":8832,"version":2,"created":1554920867000,"modified":1554920870000,"deprecated":false,"name":"Cathelicidin antimicrobial peptide","accession":"P49913","gene":"CAMP","description":"Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3116246776624654,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2089.32237,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.65394392133953,"pubTatorScore":3.188810790595069,"self":"https://pharos.nih.gov/idg/api/v1/targets(8832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":523,"href":"https://pharos.nih.gov/idg/api/v1/targets(8832)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(8832)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8832)/synonyms"},"_publications":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(8832)/publications"},"_namespace":null},{"id":8833,"version":2,"created":1554920872000,"modified":1554920875000,"deprecated":false,"name":"Collagen alpha-3(V) chain","accession":"P25940","gene":"COL5A3","description":"Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.80962187683009,"antibodyCount":73,"monoclonalCount":20,"pubmedCount":null,"jensenScore":6.179243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.83545577846027,"pubTatorScore":1.1220447161340998,"self":"https://pharos.nih.gov/idg/api/v1/targets(8833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(8833)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(8833)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8833)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8833)/publications"},"_namespace":null},{"id":8834,"version":2,"created":1554920876000,"modified":1554920880000,"deprecated":false,"name":"Neurocalcin-delta","accession":"P61601","gene":"NCALD","description":"May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.309395520716623,"antibodyCount":102,"monoclonalCount":5,"pubmedCount":null,"jensenScore":20.746612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.341601513842136,"pubTatorScore":1.1200394860846368,"self":"https://pharos.nih.gov/idg/api/v1/targets(8834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(8834)/properties"},"_links":{"count":1232,"href":"https://pharos.nih.gov/idg/api/v1/targets(8834)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8834)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8834)/publications"},"_namespace":null},{"id":8835,"version":3,"created":1554920881000,"modified":1555038498000,"deprecated":false,"name":"Protein transport protein Sec61 subunit alpha isoform 1","accession":"P61619","gene":"SEC61A1","description":"Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.466632183656537,"antibodyCount":120,"monoclonalCount":5,"pubmedCount":null,"jensenScore":293.529469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.59477511110969,"pubTatorScore":2.2766094920332436,"self":"https://pharos.nih.gov/idg/api/v1/targets(8835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(8835)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(8835)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8835)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8835)/publications"},"_namespace":null},{"id":8836,"version":2,"created":1554920886000,"modified":1554920888000,"deprecated":false,"name":"Mitochondrial fission regulator 1-like","accession":"Q9H019","gene":"MTFR1L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.73885099190673,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(8836)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(8836)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8836)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8836)/publications"},"_namespace":null},{"id":8837,"version":3,"created":1554920889000,"modified":1555038500000,"deprecated":false,"name":"Bone morphogenetic protein 4","accession":"P12644","gene":"BMP4","description":"Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.216603870170991,"antibodyCount":540,"monoclonalCount":177,"pubmedCount":null,"jensenScore":1658.54734,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":48.105946316671925,"pubTatorScore":2.863607028932451,"self":"https://pharos.nih.gov/idg/api/v1/targets(8837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(8837)/properties"},"_links":{"count":1379,"href":"https://pharos.nih.gov/idg/api/v1/targets(8837)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8837)/synonyms"},"_publications":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(8837)/publications"},"_namespace":null},{"id":8838,"version":2,"created":1554920900000,"modified":1554920903000,"deprecated":false,"name":"Zinc finger protein 530","accession":"Q6P9A1","gene":"ZNF530","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.685173593603203,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(8838)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(8838)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8838)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8838)/publications"},"_namespace":null},{"id":8839,"version":2,"created":1554920904000,"modified":1554920907000,"deprecated":false,"name":"Polypeptide N-acetylgalactosaminyltransferase 18","accession":"Q6P9A2","gene":"GALNT18","description":"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5464741198464285,"antibodyCount":37,"monoclonalCount":14,"pubmedCount":null,"jensenScore":3.287337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.70955449108423,"pubTatorScore":0.057991892690873126,"self":"https://pharos.nih.gov/idg/api/v1/targets(8839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8839)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(8839)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8839)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8839)/publications"},"_namespace":null},{"id":8840,"version":2,"created":1554920908000,"modified":1554920911000,"deprecated":false,"name":"Solute carrier family 22 member 4","accession":"Q9H015","gene":"SLC22A4","description":"Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-3.0992779328857294,"antibodyCount":82,"monoclonalCount":8,"pubmedCount":null,"jensenScore":1238.915992,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.811478209212474,"pubTatorScore":2.1540373916277322,"self":"https://pharos.nih.gov/idg/api/v1/targets(8840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(8840)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(8840)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8840)/synonyms"},"_publications":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(8840)/publications"},"_namespace":null},{"id":8841,"version":2,"created":1554920912000,"modified":1554920919000,"deprecated":false,"name":"Bone morphogenetic protein 2","accession":"P12643","gene":"BMP2","description":"Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.6572813102044552,"antibodyCount":684,"monoclonalCount":184,"pubmedCount":null,"jensenScore":4647.883686,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.89328882137696,"pubTatorScore":3.4152655730822747,"self":"https://pharos.nih.gov/idg/api/v1/targets(8841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8841)/properties"},"_links":{"count":1465,"href":"https://pharos.nih.gov/idg/api/v1/targets(8841)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8841)/synonyms"},"_publications":{"count":565,"href":"https://pharos.nih.gov/idg/api/v1/targets(8841)/publications"},"_namespace":null},{"id":8842,"version":2,"created":1554920922000,"modified":1554920925000,"deprecated":false,"name":"Bone morphogenetic protein 3","accession":"P12645","gene":"BMP3","description":"Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1135369126284878,"antibodyCount":361,"monoclonalCount":8,"pubmedCount":null,"jensenScore":130.527784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.601835116887795,"pubTatorScore":1.7436008472682971,"self":"https://pharos.nih.gov/idg/api/v1/targets(8842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(8842)/properties"},"_links":{"count":775,"href":"https://pharos.nih.gov/idg/api/v1/targets(8842)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8842)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8842)/publications"},"_namespace":null},{"id":8843,"version":2,"created":1554920925000,"modified":1554920928000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 19","accession":"Q9H013","gene":"ADAM19","description":"Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5936502696445323,"antibodyCount":184,"monoclonalCount":18,"pubmedCount":null,"jensenScore":43.039437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.332042255676704,"pubTatorScore":1.5316102840262116,"self":"https://pharos.nih.gov/idg/api/v1/targets(8843)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(8843)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(8843)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(8843)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(8843)/publications"},"_namespace":null},{"id":8844,"version":2,"created":1554920929000,"modified":1554920934000,"deprecated":false,"name":"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial","accession":"P11310","gene":"ACADM","description":"Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0155739588344366,"antibodyCount":321,"monoclonalCount":32,"pubmedCount":null,"jensenScore":101.354172,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.84169550497271,"pubTatorScore":2.7858664998747016,"self":"https://pharos.nih.gov/idg/api/v1/targets(8844)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":547,"href":"https://pharos.nih.gov/idg/api/v1/targets(8844)/properties"},"_links":{"count":1204,"href":"https://pharos.nih.gov/idg/api/v1/targets(8844)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8844)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8844)/publications"},"_namespace":null},{"id":8845,"version":2,"created":1554920935000,"modified":1554920940000,"deprecated":false,"name":"Selenoprotein P","accession":"P49908","gene":"SELENOP","description":"Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4886835961946625,"antibodyCount":110,"monoclonalCount":13,"pubmedCount":null,"jensenScore":339.458317,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.025779013000669,"self":"https://pharos.nih.gov/idg/api/v1/targets(8845)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(8845)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(8845)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8845)/synonyms"},"_publications":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8845)/publications"},"_namespace":null},{"id":8846,"version":2,"created":1554920941000,"modified":1554920944000,"deprecated":false,"name":"39S ribosomal protein L3, mitochondrial","accession":"P09001","gene":"MRPL3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8553172167771292,"antibodyCount":142,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.9,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.90092906430645,"pubTatorScore":1.001772987864674,"self":"https://pharos.nih.gov/idg/api/v1/targets(8846)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(8846)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(8846)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8846)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8846)/publications"},"_namespace":null},{"id":8847,"version":2,"created":1554920945000,"modified":1554920947000,"deprecated":false,"name":"60S ribosomal protein L41","accession":"P62945","gene":"RPL41","description":"Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6969843959311932,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":47.418607,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.907735691636606,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8847)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(8847)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(8847)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8847)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8847)/publications"},"_namespace":null},{"id":8848,"version":2,"created":1554920948000,"modified":1554920948000,"deprecated":false,"name":"Killer cell immunoglobulin-like receptor 2DL5B","accession":"Q8NHK3","gene":"KIR2DL5B","description":"Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.9059645844852855,"pubTatorScore":0.5542871691324731,"self":"https://pharos.nih.gov/idg/api/v1/targets(8848)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8848)/properties"},"_links":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8848)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8848)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8848)/publications"},"_namespace":null},{"id":8849,"version":2,"created":1554920949000,"modified":1554920952000,"deprecated":false,"name":"Selenide, water dikinase 1","accession":"P49903","gene":"SEPHS1","description":"Synthesizes selenophosphate from selenide and ATP.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7389915952214527,"antibodyCount":124,"monoclonalCount":12,"pubmedCount":null,"jensenScore":51.595948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.18774734635287,"pubTatorScore":1.4457770772172103,"self":"https://pharos.nih.gov/idg/api/v1/targets(8849)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(8849)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8849)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(8849)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8849)/publications"},"_namespace":null},{"id":8850,"version":2,"created":1554920953000,"modified":1554920958000,"deprecated":false,"name":"Cytosolic purine 5'-nucleotidase","accession":"P49902","gene":"NT5C2","description":"May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2434764730408365,"antibodyCount":144,"monoclonalCount":13,"pubmedCount":null,"jensenScore":166.780371,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.76438970178263,"pubTatorScore":2.8222775457158575,"self":"https://pharos.nih.gov/idg/api/v1/targets(8850)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":457,"href":"https://pharos.nih.gov/idg/api/v1/targets(8850)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(8850)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(8850)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8850)/publications"},"_namespace":null},{"id":8851,"version":2,"created":1554920959000,"modified":1554920961000,"deprecated":false,"name":"Sperm mitochondrial-associated cysteine-rich protein","accession":"P49901","gene":"SMCP","description":"Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9821831323117156,"antibodyCount":133,"monoclonalCount":59,"pubmedCount":null,"jensenScore":96.572904,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.360779455122424,"pubTatorScore":0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8851)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(8851)/properties"},"_links":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(8851)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8851)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8851)/publications"},"_namespace":null},{"id":8852,"version":4,"created":1554920961000,"modified":1555038503000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase FKBP1A","accession":"P62942","gene":"FKBP1A","description":"Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.779233121461013,"antibodyCount":271,"monoclonalCount":56,"pubmedCount":null,"jensenScore":382.794395,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.74520775602933,"pubTatorScore":2.238818277180985,"self":"https://pharos.nih.gov/idg/api/v1/targets(8852)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(8852)/properties"},"_links":{"count":1509,"href":"https://pharos.nih.gov/idg/api/v1/targets(8852)/links"},"_synonyms":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(8852)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8852)/publications"},"_namespace":null},{"id":8853,"version":2,"created":1554921094000,"modified":1554921098000,"deprecated":false,"name":"Anosmin-1","accession":"P23352","gene":"ANOS1","description":"Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.640382667922597,"antibodyCount":155,"monoclonalCount":26,"pubmedCount":null,"jensenScore":424.567202,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.662512108978813,"pubTatorScore":2.351181760967006,"self":"https://pharos.nih.gov/idg/api/v1/targets(8853)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(8853)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(8853)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8853)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8853)/publications"},"_namespace":null},{"id":8854,"version":2,"created":1554921099000,"modified":1554921102000,"deprecated":false,"name":"Phosphatidylserine synthase 1","accession":"P48651","gene":"PTDSS1","description":"Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9397052964454726,"antibodyCount":109,"monoclonalCount":4,"pubmedCount":null,"jensenScore":87.087333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.94637143073028,"pubTatorScore":1.198636278802603,"self":"https://pharos.nih.gov/idg/api/v1/targets(8854)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8854)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(8854)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8854)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8854)/publications"},"_namespace":null},{"id":8855,"version":2,"created":1554921103000,"modified":1554921107000,"deprecated":false,"name":"Gamma-glutamylcyclotransferase","accession":"O75223","gene":"GGCT","description":"Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2049455789706096,"antibodyCount":128,"monoclonalCount":2,"pubmedCount":null,"jensenScore":142.509459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.184372727994635,"pubTatorScore":2.0705347884049075,"self":"https://pharos.nih.gov/idg/api/v1/targets(8855)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(8855)/properties"},"_links":{"count":1137,"href":"https://pharos.nih.gov/idg/api/v1/targets(8855)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8855)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8855)/publications"},"_namespace":null},{"id":8856,"version":3,"created":1554921108000,"modified":1555038506000,"deprecated":false,"name":"Volume-regulated anion channel subunit LRRC8B","accession":"Q6P9F7","gene":"LRRC8B","description":"Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4648868019217715,"antibodyCount":85,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.634916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":34.29621358161168,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8856)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(8856)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(8856)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8856)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8856)/publications"},"_namespace":null},{"id":8857,"version":2,"created":1554921111000,"modified":1554921112000,"deprecated":false,"name":"Tripartite motif-containing protein 40","accession":"Q6P9F5","gene":"TRIM40","description":"May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.050184194640825366,"antibodyCount":65,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.702349,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.674321108355365,"pubTatorScore":-0.01046564552918342,"self":"https://pharos.nih.gov/idg/api/v1/targets(8857)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(8857)/properties"},"_links":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(8857)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8857)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8857)/publications"},"_namespace":null},{"id":8858,"version":3,"created":1554921113000,"modified":1555038507000,"deprecated":false,"name":"DnaJ homolog subfamily B member 8","accession":"Q8NHS0","gene":"DNAJB8","description":"Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5703487657616146,"antibodyCount":82,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.179181,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":17.522340648414414,"pubTatorScore":0.7914848892319745,"self":"https://pharos.nih.gov/idg/api/v1/targets(8858)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(8858)/properties"},"_links":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(8858)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8858)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8858)/publications"},"_namespace":null},{"id":8859,"version":2,"created":1554921115000,"modified":1554921117000,"deprecated":false,"name":"Large subunit GTPase 1 homolog","accession":"Q9H089","gene":"LSG1","description":"GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.109466034607021,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.124783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.929478642773475,"pubTatorScore":0.7781511780012239,"self":"https://pharos.nih.gov/idg/api/v1/targets(8859)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(8859)/properties"},"_links":{"count":1080,"href":"https://pharos.nih.gov/idg/api/v1/targets(8859)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8859)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8859)/publications"},"_namespace":null},{"id":8860,"version":3,"created":1554921118000,"modified":1555038508000,"deprecated":false,"name":"2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial","accession":"P12694","gene":"BCKDHA","description":"The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.847668839961718,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":717.977103,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.87244501674598,"pubTatorScore":1.5263730631522927,"self":"https://pharos.nih.gov/idg/api/v1/targets(8860)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(8860)/properties"},"_links":{"count":1183,"href":"https://pharos.nih.gov/idg/api/v1/targets(8860)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(8860)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8860)/publications"},"_namespace":null},{"id":8861,"version":2,"created":1554921123000,"modified":1554921125000,"deprecated":false,"name":"Claudin domain-containing protein 2","accession":"Q8NHS1","gene":"CLDND2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.61101558432408,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8861)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(8861)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(8861)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(8861)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8861)/publications"},"_namespace":null},{"id":8862,"version":2,"created":1554921125000,"modified":1554921128000,"deprecated":false,"name":"Coiled-coil domain-containing protein 62","accession":"Q6P9F0","gene":"CCDC62","description":"Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9191367716960755,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.087017,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.70534147999097,"pubTatorScore":1.1962086660669544,"self":"https://pharos.nih.gov/idg/api/v1/targets(8862)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(8862)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(8862)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8862)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(8862)/publications"},"_namespace":null},{"id":8863,"version":3,"created":1554921129000,"modified":1555038509000,"deprecated":false,"name":"Ly6/PLAUR domain-containing protein 6B","accession":"Q8NI32","gene":"LYPD6B","description":"Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.36974580629626314,"antibodyCount":19,"monoclonalCount":11,"pubmedCount":null,"jensenScore":2.766956,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":24.889211965211334,"pubTatorScore":0.29582869732888806,"self":"https://pharos.nih.gov/idg/api/v1/targets(8863)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(8863)/properties"},"_links":{"count":750,"href":"https://pharos.nih.gov/idg/api/v1/targets(8863)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8863)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8863)/publications"},"_namespace":null},{"id":8864,"version":2,"created":1554921131000,"modified":1554921132000,"deprecated":false,"name":"Telomere repeats-binding bouquet formation protein 2","accession":"Q8NHR7","gene":"TERB2","description":"Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.263158,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8864)/properties"},"_links":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(8864)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8864)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8864)/publications"},"_namespace":null},{"id":8865,"version":3,"created":1554921132000,"modified":1555038510000,"deprecated":false,"name":"Protein phosphatase PTC7 homolog","accession":"Q8NI37","gene":"PPTC7","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.5093059379876602,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.233766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":31.18548108222629,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8865)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(8865)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(8865)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8865)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8865)/publications"},"_namespace":null},{"id":8866,"version":3,"created":1554921136000,"modified":1555038511000,"deprecated":false,"name":"Protein MIS12 homolog","accession":"Q9H081","gene":"MIS12","description":"Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8396725549649428,"antibodyCount":127,"monoclonalCount":25,"pubmedCount":null,"jensenScore":5.380127,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.414277769786054,"pubTatorScore":1.1961283574890322,"self":"https://pharos.nih.gov/idg/api/v1/targets(8866)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(8866)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(8866)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8866)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8866)/publications"},"_namespace":null},{"id":8867,"version":3,"created":1554921140000,"modified":1555038514000,"deprecated":false,"name":"NF-kappa-B inhibitor delta","accession":"Q8NI38","gene":"NFKBID","description":"May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2255861823353027,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.375011,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":25.436983593797834,"pubTatorScore":0.4343590507864383,"self":"https://pharos.nih.gov/idg/api/v1/targets(8867)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(8867)/properties"},"_links":{"count":808,"href":"https://pharos.nih.gov/idg/api/v1/targets(8867)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8867)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8867)/publications"},"_namespace":null},{"id":8868,"version":2,"created":1554921143000,"modified":1554921146000,"deprecated":false,"name":"InaD-like protein","accession":"Q8NI35","gene":"PATJ","description":"Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9423605174084622,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":81.959902,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.6177474504264489,"self":"https://pharos.nih.gov/idg/api/v1/targets(8868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(8868)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(8868)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8868)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(8868)/publications"},"_namespace":null},{"id":8869,"version":2,"created":1554921147000,"modified":1554921148000,"deprecated":false,"name":"Putative olfactory receptor 8G2","accession":"Q6IF36","gene":"OR8G2P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(8869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8869)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8869)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(8869)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8869)/publications"},"_namespace":null},{"id":8870,"version":3,"created":1554921148000,"modified":1555038515000,"deprecated":false,"name":"Ras-related protein Rab-33B","accession":"Q9H082","gene":"RAB33B","description":"Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9511485679761107,"antibodyCount":53,"monoclonalCount":25,"pubmedCount":null,"jensenScore":8.886816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":32.61424812389094,"pubTatorScore":0.9075690863755859,"self":"https://pharos.nih.gov/idg/api/v1/targets(8870)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(8870)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(8870)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8870)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8870)/publications"},"_namespace":null},{"id":8871,"version":3,"created":1554921151000,"modified":1555038516000,"deprecated":false,"name":"WD repeat-containing protein 36","accession":"Q8NI36","gene":"WDR36","description":"Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7169462991994853,"antibodyCount":29,"monoclonalCount":6,"pubmedCount":null,"jensenScore":52.016313,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.481712647633444,"pubTatorScore":1.5787630407229751,"self":"https://pharos.nih.gov/idg/api/v1/targets(8871)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(8871)/properties"},"_links":{"count":1094,"href":"https://pharos.nih.gov/idg/api/v1/targets(8871)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8871)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8871)/publications"},"_namespace":null},{"id":8872,"version":2,"created":1554921156000,"modified":1554921157000,"deprecated":false,"name":"Uroplakin-3b-like protein 1","accession":"B0FP48","gene":"UPK3BL2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.03476210770686023,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8872)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(8872)/properties"},"_links":{"count":717,"href":"https://pharos.nih.gov/idg/api/v1/targets(8872)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8872)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8872)/publications"},"_namespace":null},{"id":8873,"version":2,"created":1554921158000,"modified":1554921160000,"deprecated":false,"name":"Neuromedin-U","accession":"P48645","gene":"NMU","description":"Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.80210221742243,"antibodyCount":99,"monoclonalCount":2,"pubmedCount":null,"jensenScore":666.620772,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.240405810875558,"pubTatorScore":1.881274842285794,"self":"https://pharos.nih.gov/idg/api/v1/targets(8873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(8873)/properties"},"_links":{"count":710,"href":"https://pharos.nih.gov/idg/api/v1/targets(8873)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8873)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8873)/publications"},"_namespace":null},{"id":8874,"version":2,"created":1554921161000,"modified":1554921163000,"deprecated":false,"name":"Profilin-4","accession":"Q8NHR9","gene":"PFN4","description":"Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin (PubMed:19419568), contrary to other family members.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5238646552021866,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.406494,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.267012881642287,"pubTatorScore":0.40369228041711436,"self":"https://pharos.nih.gov/idg/api/v1/targets(8874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(8874)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(8874)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8874)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8874)/publications"},"_namespace":null},{"id":8875,"version":3,"created":1554921163000,"modified":1555038518000,"deprecated":false,"name":"T-complex protein 1 subunit epsilon","accession":"P48643","gene":"CCT5","description":"Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4754898986673335,"antibodyCount":222,"monoclonalCount":66,"pubmedCount":null,"jensenScore":27.774673,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":49.4456889069558,"pubTatorScore":1.1118436490179777,"self":"https://pharos.nih.gov/idg/api/v1/targets(8875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8875)/properties"},"_links":{"count":1174,"href":"https://pharos.nih.gov/idg/api/v1/targets(8875)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8875)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8875)/publications"},"_namespace":null},{"id":8876,"version":2,"created":1554921169000,"modified":1554921171000,"deprecated":false,"name":"Cytochrome b5 domain-containing protein 1","accession":"Q6P9G0","gene":"CYB5D1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.09691001300805639,"antibodyCount":76,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.492087990597202,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8876)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(8876)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8876)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8876)/publications"},"_namespace":null},{"id":8877,"version":3,"created":1554921171000,"modified":1555038519000,"deprecated":false,"name":"Protein phosphatase Slingshot homolog 2","accession":"Q76I76","gene":"SSH2","description":"Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7552768614453685,"antibodyCount":30,"monoclonalCount":12,"pubmedCount":null,"jensenScore":5.005709,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.132188727426175,"pubTatorScore":0.5615296206576625,"self":"https://pharos.nih.gov/idg/api/v1/targets(8877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(8877)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(8877)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8877)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8877)/publications"},"_namespace":null},{"id":8878,"version":2,"created":1554921174000,"modified":1554921177000,"deprecated":false,"name":"Cornifin-A","accession":"P35321","gene":"SPRR1A","description":"Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2259820661140806,"antibodyCount":80,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.095711,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.929134743873302,"pubTatorScore":1.24821549585965,"self":"https://pharos.nih.gov/idg/api/v1/targets(8878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(8878)/properties"},"_links":{"count":712,"href":"https://pharos.nih.gov/idg/api/v1/targets(8878)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8878)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8878)/publications"},"_namespace":null},{"id":8879,"version":3,"created":1554921177000,"modified":1555038521000,"deprecated":false,"name":"Caseinolytic peptidase B protein homolog","accession":"Q9H078","gene":"CLPB","description":"May function as a regulatory ATPase and be related to secretion/protein trafficking process.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.462756569119646,"antibodyCount":143,"monoclonalCount":2,"pubmedCount":null,"jensenScore":317.113932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":44.20648071433853,"pubTatorScore":1.8643899897591474,"self":"https://pharos.nih.gov/idg/api/v1/targets(8879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(8879)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(8879)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8879)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8879)/publications"},"_namespace":null},{"id":8880,"version":3,"created":1554921181000,"modified":1555038523000,"deprecated":false,"name":"Transmembrane protein 154","accession":"Q6P9G4","gene":"TMEM154","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.032020143661818,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.891559,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":24.14355001398492,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(8880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(8880)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(8880)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8880)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8880)/publications"},"_namespace":null},{"id":8881,"version":2,"created":1554921184000,"modified":1554921187000,"deprecated":false,"name":"Small proline-rich protein 2A","accession":"P35326","gene":"SPRR2A","description":"Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0288211359648824,"antibodyCount":78,"monoclonalCount":5,"pubmedCount":null,"jensenScore":9.146286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.221225131108506,"pubTatorScore":2.691567698671016,"self":"https://pharos.nih.gov/idg/api/v1/targets(8881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(8881)/properties"},"_links":{"count":662,"href":"https://pharos.nih.gov/idg/api/v1/targets(8881)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(8881)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8881)/publications"},"_namespace":null},{"id":8882,"version":3,"created":1554921187000,"modified":1555038524000,"deprecated":false,"name":"KATNB1-like protein 1","accession":"Q9H079","gene":"KATNBL1","description":"Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":72,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.411765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.972622504045063,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(8882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(8882)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(8882)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8882)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8882)/publications"},"_namespace":null},{"id":8883,"version":2,"created":1554921192000,"modified":1554921193000,"deprecated":false,"name":"Small proline-rich protein 2B","accession":"P35325","gene":"SPRR2B","description":"Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.04728200344401262,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.784133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.6652639884911,"pubTatorScore":0.3744898913906681,"self":"https://pharos.nih.gov/idg/api/v1/targets(8883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(8883)/properties"},"_links":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(8883)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(8883)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8883)/publications"},"_namespace":null},{"id":8884,"version":3,"created":1554921193000,"modified":1555038525000,"deprecated":false,"name":"Polyadenylate-binding protein-interacting protein 1","accession":"Q9H074","gene":"PAIP1","description":"Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.979129631518199,"antibodyCount":142,"monoclonalCount":19,"pubmedCount":null,"jensenScore":7.718481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":34.13690168435756,"pubTatorScore":1.0599779390604904,"self":"https://pharos.nih.gov/idg/api/v1/targets(8884)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(8884)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(8884)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(8884)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8884)/publications"},"_namespace":null},{"id":8885,"version":3,"created":1554921198000,"modified":1555038526000,"deprecated":false,"name":"Multiple coagulation factor deficiency protein 2","accession":"Q8NI22","gene":"MCFD2","description":"The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5217864218507622,"antibodyCount":143,"monoclonalCount":67,"pubmedCount":null,"jensenScore":33.437226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.761752440390346,"pubTatorScore":1.482414131390189,"self":"https://pharos.nih.gov/idg/api/v1/targets(8885)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(8885)/properties"},"_links":{"count":1194,"href":"https://pharos.nih.gov/idg/api/v1/targets(8885)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(8885)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8885)/publications"},"_namespace":null},{"id":8886,"version":3,"created":1554921203000,"modified":1555038528000,"deprecated":false,"name":"Olfactory receptor 2A2","accession":"Q6IF42","gene":"OR2A2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":11,"monoclonalCount":9,"pubmedCount":null,"jensenScore":0.0,"patentCount":111,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":8.76351238232821,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(8886)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8886)/properties"},"_links":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8886)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8886)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8886)/publications"},"_namespace":null},{"id":8887,"version":2,"created":1554921203000,"modified":1554921206000,"deprecated":false,"name":"Centrosomal protein of 70 kDa","accession":"Q8NHQ1","gene":"CEP70","description":"Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.223226197587893,"antibodyCount":123,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1506.178493,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.984262692692454,"pubTatorScore":1.7462448717201984,"self":"https://pharos.nih.gov/idg/api/v1/targets(8887)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8887)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(8887)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(8887)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8887)/publications"},"_namespace":null},{"id":8888,"version":2,"created":1554921207000,"modified":1554921211000,"deprecated":false,"name":"THO complex subunit 2","accession":"Q8NI27","gene":"THOC2","description":"Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8977670217983036,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":77.773727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.1198371198159,"pubTatorScore":1.6673862158469992,"self":"https://pharos.nih.gov/idg/api/v1/targets(8888)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(8888)/properties"},"_links":{"count":1121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8888)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8888)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(8888)/publications"},"_namespace":null},{"id":8889,"version":2,"created":1554921212000,"modified":1554921215000,"deprecated":false,"name":"Protein PRRC2A","accession":"P48634","gene":"PRRC2A","description":"May play a role in the regulation of pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9323809467566968,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":84.761141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.36164089987067,"pubTatorScore":1.6908308115289963,"self":"https://pharos.nih.gov/idg/api/v1/targets(8889)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(8889)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(8889)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(8889)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8889)/publications"},"_namespace":null},{"id":8890,"version":2,"created":1554921216000,"modified":1554921216000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC01006","accession":"Q8NI28","gene":"LINC01006","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2803453958508008,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.123218129693006,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8890)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(8890)/properties"},"_links":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8890)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(8890)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8890)/publications"},"_namespace":null},{"id":8891,"version":3,"created":1554921216000,"modified":1555038528000,"deprecated":false,"name":"Ras association domain-containing protein 8","accession":"Q8NHQ8","gene":"RASSF8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0089548589389699,"antibodyCount":267,"monoclonalCount":102,"pubmedCount":null,"jensenScore":8.371862,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":35.205829004276104,"pubTatorScore":0.8007606429804465,"self":"https://pharos.nih.gov/idg/api/v1/targets(8891)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(8891)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(8891)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8891)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8891)/publications"},"_namespace":null},{"id":8892,"version":3,"created":1554921220000,"modified":1555038531000,"deprecated":false,"name":"Homeobox protein Hox-B5","accession":"P09067","gene":"HOXB5","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8378231666004905,"antibodyCount":179,"monoclonalCount":24,"pubmedCount":null,"jensenScore":66.390514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":31,"knowledgeAvailability":34.22643992155272,"pubTatorScore":1.653664851582253,"self":"https://pharos.nih.gov/idg/api/v1/targets(8892)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(8892)/properties"},"_links":{"count":664,"href":"https://pharos.nih.gov/idg/api/v1/targets(8892)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(8892)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(8892)/publications"},"_namespace":null},{"id":8893,"version":2,"created":1554921223000,"modified":1554921226000,"deprecated":false,"name":"ATP-dependent RNA helicase DDX55","accession":"Q8NHQ9","gene":"DDX55","description":"Probable ATP-binding RNA helicase.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":109,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.33831848334631,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8893)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(8893)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(8893)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8893)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(8893)/publications"},"_namespace":null},{"id":8894,"version":2,"created":1554921227000,"modified":1554921229000,"deprecated":false,"name":"F-box only protein 27","accession":"Q8NI29","gene":"FBXO27","description":"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.21664755282844522,"antibodyCount":84,"monoclonalCount":21,"pubmedCount":null,"jensenScore":1.372194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.94526647651525,"pubTatorScore":0.6715842552421799,"self":"https://pharos.nih.gov/idg/api/v1/targets(8894)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(8894)/properties"},"_links":{"count":838,"href":"https://pharos.nih.gov/idg/api/v1/targets(8894)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8894)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8894)/publications"},"_namespace":null},{"id":8895,"version":2,"created":1554921230000,"modified":1554921234000,"deprecated":false,"name":"Glutathione synthetase","accession":"P48637","gene":"GSS","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7813936060649733,"antibodyCount":229,"monoclonalCount":61,"pubmedCount":null,"jensenScore":592.785948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.88608680487713,"pubTatorScore":2.3768778097783647,"self":"https://pharos.nih.gov/idg/api/v1/targets(8895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(8895)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(8895)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8895)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8895)/publications"},"_namespace":null},{"id":8896,"version":2,"created":1554921235000,"modified":1554921238000,"deprecated":false,"name":"Ubiquinone biosynthesis protein COQ9, mitochondrial","accession":"O75208","gene":"COQ9","description":"Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9980945931369243,"antibodyCount":77,"monoclonalCount":0,"pubmedCount":null,"jensenScore":101.86917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.7606741075924,"pubTatorScore":1.422677379281061,"self":"https://pharos.nih.gov/idg/api/v1/targets(8896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(8896)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(8896)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(8896)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(8896)/publications"},"_namespace":null},{"id":8897,"version":2,"created":1554921239000,"modified":1554921243000,"deprecated":false,"name":"ADM","accession":"P35318","gene":"ADM","description":"AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.275044540844742,"antibodyCount":381,"monoclonalCount":91,"pubmedCount":null,"jensenScore":1888.966481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.8555554988284,"pubTatorScore":3.0325095337373518,"self":"https://pharos.nih.gov/idg/api/v1/targets(8897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":686,"href":"https://pharos.nih.gov/idg/api/v1/targets(8897)/properties"},"_links":{"count":1240,"href":"https://pharos.nih.gov/idg/api/v1/targets(8897)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8897)/synonyms"},"_publications":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(8897)/publications"},"_namespace":null},{"id":8898,"version":2,"created":1554921245000,"modified":1554921250000,"deprecated":false,"name":"Ectonucleoside triphosphate diphosphohydrolase 1","accession":"P49961","gene":"ENTPD1","description":"In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.682490325678231,"antibodyCount":505,"monoclonalCount":345,"pubmedCount":null,"jensenScore":518.78695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.530412146574285,"pubTatorScore":2.47602216266151,"self":"https://pharos.nih.gov/idg/api/v1/targets(8898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(8898)/properties"},"_links":{"count":1220,"href":"https://pharos.nih.gov/idg/api/v1/targets(8898)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(8898)/synonyms"},"_publications":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(8898)/publications"},"_namespace":null},{"id":8899,"version":2,"created":1554921252000,"modified":1554921256000,"deprecated":false,"name":"Transmembrane protein 127","accession":"O75204","gene":"TMEM127","description":"Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3136542511522116,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":19.463163,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.18385496790733,"pubTatorScore":1.3087275154621343,"self":"https://pharos.nih.gov/idg/api/v1/targets(8899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(8899)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(8899)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8899)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8899)/publications"},"_namespace":null},{"id":8900,"version":2,"created":1554921256000,"modified":1554921258000,"deprecated":false,"name":"Nuclear pore complex-interacting protein family member B7","accession":"O75200","gene":"NPIPB7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.1809468867174475,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(8900)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(8900)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8900)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8900)/publications"},"_namespace":null},{"id":8901,"version":3,"created":1554921259000,"modified":1555038533000,"deprecated":false,"name":"Dynein regulatory complex subunit 3","accession":"Q9H069","gene":"DRC3","description":"Key component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary motility.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.470588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":0.0,"pubTatorScore":0.5542871691324731,"self":"https://pharos.nih.gov/idg/api/v1/targets(8901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(8901)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(8901)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8901)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8901)/publications"},"_namespace":null},{"id":8902,"version":2,"created":1554921262000,"modified":1554921263000,"deprecated":false,"name":"Aflatoxin B1 aldehyde reductase member 4","accession":"Q8NHP1","gene":"AKR7L","description":"Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.0150891467636889,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.24969,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.911383000801406,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(8902)/properties"},"_links":{"count":649,"href":"https://pharos.nih.gov/idg/api/v1/targets(8902)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8902)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8902)/publications"},"_namespace":null},{"id":8903,"version":3,"created":1554921264000,"modified":1555038534000,"deprecated":false,"name":"Repressor of RNA polymerase III transcription MAF1 homolog","accession":"Q9H063","gene":"MAF1","description":"Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7890349351471173,"antibodyCount":127,"monoclonalCount":6,"pubmedCount":null,"jensenScore":66.487527,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":34.08534537388799,"pubTatorScore":1.5197863336211388,"self":"https://pharos.nih.gov/idg/api/v1/targets(8903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(8903)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(8903)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8903)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8903)/publications"},"_namespace":null},{"id":8904,"version":3,"created":1554921267000,"modified":1555038535000,"deprecated":false,"name":"Double-strand break repair protein MRE11","accession":"P49959","gene":"MRE11","description":"Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.027622645495572,"antibodyCount":459,"monoclonalCount":87,"pubmedCount":null,"jensenScore":98.453432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":2.53187117472456,"self":"https://pharos.nih.gov/idg/api/v1/targets(8904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(8904)/properties"},"_links":{"count":1274,"href":"https://pharos.nih.gov/idg/api/v1/targets(8904)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(8904)/synonyms"},"_publications":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(8904)/publications"},"_namespace":null},{"id":8905,"version":3,"created":1554921274000,"modified":1555038538000,"deprecated":false,"name":"60S ribosomal protein L14","accession":"P50914","gene":"RPL14","description":"Component of the large ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6705282866827758,"antibodyCount":161,"monoclonalCount":26,"pubmedCount":null,"jensenScore":43.188316,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":59,"knowledgeAvailability":37.71205794264625,"pubTatorScore":1.5400286060242832,"self":"https://pharos.nih.gov/idg/api/v1/targets(8905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8905)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(8905)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(8905)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(8905)/publications"},"_namespace":null},{"id":8906,"version":2,"created":1554921278000,"modified":1554921280000,"deprecated":false,"name":"Motile sperm domain-containing protein 2","accession":"Q8NHP6","gene":"MOSPD2","description":"Promotes migration of primary monocytes and neutrophils, in response to various chemokines.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.23146150196236726,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.598611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.798567091152538,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(8906)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(8906)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8906)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8906)/publications"},"_namespace":null},{"id":8907,"version":3,"created":1554921281000,"modified":1555038540000,"deprecated":false,"name":"Transmembrane protein 126A","accession":"Q9H061","gene":"TMEM126A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0007232244420101,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.827273,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":30.771439370466325,"pubTatorScore":0.985276713227949,"self":"https://pharos.nih.gov/idg/api/v1/targets(8907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(8907)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(8907)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8907)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8907)/publications"},"_namespace":null},{"id":8908,"version":2,"created":1554921285000,"modified":1554921286000,"deprecated":false,"name":"piRNA biogenesis protein EXD1","accession":"Q8NHP7","gene":"EXD1","description":"RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":64,"monoclonalCount":55,"pubmedCount":null,"jensenScore":0.206897,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.144708701630435,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(8908)/properties"},"_links":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(8908)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8908)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8908)/publications"},"_namespace":null},{"id":8909,"version":3,"created":1554921287000,"modified":1555038542000,"deprecated":false,"name":"Interleukin-31 receptor subunit alpha","accession":"Q8NI17","gene":"IL31RA","description":"Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.901069146473692,"antibodyCount":192,"monoclonalCount":55,"pubmedCount":null,"jensenScore":764.539777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":23.190586280095342,"pubTatorScore":2.471449825619952,"self":"https://pharos.nih.gov/idg/api/v1/targets(8909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(8909)/properties"},"_links":{"count":656,"href":"https://pharos.nih.gov/idg/api/v1/targets(8909)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(8909)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8909)/publications"},"_namespace":null},{"id":8910,"version":2,"created":1554921291000,"modified":1554921293000,"deprecated":false,"name":"Putative phospholipase B-like 2","accession":"Q8NHP8","gene":"PLBD2","description":"Putative phospholipase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7087042042019827,"antibodyCount":83,"monoclonalCount":0,"pubmedCount":null,"jensenScore":47.425655,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.966134828502195,"pubTatorScore":1.0939217114462338,"self":"https://pharos.nih.gov/idg/api/v1/targets(8910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(8910)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(8910)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8910)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8910)/publications"},"_namespace":null},{"id":8911,"version":3,"created":1554921294000,"modified":1555038543000,"deprecated":false,"name":"Sarcoplasmic reticulum histidine-rich calcium-binding protein","accession":"P23327","gene":"HRC","description":"May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.330007559292781,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":222.494374,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":26.28355419912173,"pubTatorScore":1.5079842932766365,"self":"https://pharos.nih.gov/idg/api/v1/targets(8911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(8911)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(8911)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8911)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8911)/publications"},"_namespace":null},{"id":8912,"version":2,"created":1554921298000,"modified":1554921299000,"deprecated":false,"name":"Neuroblastoma breakpoint family member 9","accession":"Q3BBW0","gene":"NBPF9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.09394949810745,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":23.460517,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.4873404805005743,"self":"https://pharos.nih.gov/idg/api/v1/targets(8912)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8912)/properties"},"_links":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(8912)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8912)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8912)/publications"},"_namespace":null},{"id":8913,"version":3,"created":1554921299000,"modified":1555038544000,"deprecated":false,"name":"Fibroblast growth factor 2","accession":"P09038","gene":"FGF2","description":"Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-4.005418918740105,"antibodyCount":798,"monoclonalCount":342,"pubmedCount":null,"jensenScore":10573.504479,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":46.009802367447065,"pubTatorScore":3.6358112832794314,"self":"https://pharos.nih.gov/idg/api/v1/targets(8913)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1274,"href":"https://pharos.nih.gov/idg/api/v1/targets(8913)/properties"},"_links":{"count":1782,"href":"https://pharos.nih.gov/idg/api/v1/targets(8913)/links"},"_synonyms":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(8913)/synonyms"},"_publications":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(8913)/publications"},"_namespace":null},{"id":8914,"version":3,"created":1554921329000,"modified":1555038548000,"deprecated":false,"name":"7,8-dihydro-8-oxoguanine triphosphatase","accession":"P36639","gene":"NUDT1","description":"Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.433523617503105,"antibodyCount":162,"monoclonalCount":11,"pubmedCount":null,"jensenScore":259.685978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":41.032691729320916,"pubTatorScore":2.217425710632159,"self":"https://pharos.nih.gov/idg/api/v1/targets(8914)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":474,"href":"https://pharos.nih.gov/idg/api/v1/targets(8914)/properties"},"_links":{"count":1313,"href":"https://pharos.nih.gov/idg/api/v1/targets(8914)/links"},"_synonyms":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(8914)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8914)/publications"},"_namespace":null},{"id":8915,"version":3,"created":1554921343000,"modified":1555038551000,"deprecated":false,"name":"60S ribosomal protein L10a","accession":"P62906","gene":"RPL10A","description":"Component of the large ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6349778210184471,"antibodyCount":161,"monoclonalCount":39,"pubmedCount":null,"jensenScore":41.819041,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":38.779996870263254,"pubTatorScore":1.06951410593137,"self":"https://pharos.nih.gov/idg/api/v1/targets(8915)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(8915)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(8915)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8915)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(8915)/publications"},"_namespace":null},{"id":8916,"version":3,"created":1554921347000,"modified":1554921463000,"deprecated":false,"name":"Fibroblast growth factor receptor 1","accession":"P11362","gene":"FGFR1","description":"Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.1306274508405934,"antibodyCount":1785,"monoclonalCount":366,"pubmedCount":null,"jensenScore":1294.698391,"patentCount":194124,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":61.65726963178226,"pubTatorScore":2.9578946178457497,"self":"https://pharos.nih.gov/idg/api/v1/targets(8916)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8916)/properties"},"_links":{"count":2460,"href":"https://pharos.nih.gov/idg/api/v1/targets(8916)/links"},"_synonyms":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(8916)/synonyms"},"_publications":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(8916)/publications"},"_namespace":null},{"id":8917,"version":2,"created":1554921467000,"modified":1554921472000,"deprecated":false,"name":"Nuclear receptor coactivator 7","accession":"Q8NI08","gene":"NCOA7","description":"Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.070228519211663,"antibodyCount":131,"monoclonalCount":8,"pubmedCount":null,"jensenScore":13.345721,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.22964008302549,"pubTatorScore":1.0028857026181,"self":"https://pharos.nih.gov/idg/api/v1/targets(8917)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(8917)/properties"},"_links":{"count":1155,"href":"https://pharos.nih.gov/idg/api/v1/targets(8917)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(8917)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8917)/publications"},"_namespace":null},{"id":8918,"version":3,"created":1554921473000,"modified":1555038552000,"deprecated":false,"name":"Bone morphogenetic protein 5","accession":"P22003","gene":"BMP5","description":"Induces cartilage and bone formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9309412304400972,"antibodyCount":344,"monoclonalCount":81,"pubmedCount":null,"jensenScore":81.40661,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.710956757133918,"pubTatorScore":1.5599823388153597,"self":"https://pharos.nih.gov/idg/api/v1/targets(8918)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(8918)/properties"},"_links":{"count":736,"href":"https://pharos.nih.gov/idg/api/v1/targets(8918)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(8918)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8918)/publications"},"_namespace":null},{"id":8919,"version":3,"created":1554921477000,"modified":1555038553000,"deprecated":false,"name":"Low molecular weight phosphotyrosine protein phosphatase","accession":"P24666","gene":"ACP1","description":"Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.4479295019944436,"antibodyCount":248,"monoclonalCount":31,"pubmedCount":null,"jensenScore":295.298426,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":46.06710125133957,"pubTatorScore":2.3929087388558288,"self":"https://pharos.nih.gov/idg/api/v1/targets(8919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(8919)/properties"},"_links":{"count":1179,"href":"https://pharos.nih.gov/idg/api/v1/targets(8919)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(8919)/synonyms"},"_publications":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(8919)/publications"},"_namespace":null},{"id":8920,"version":2,"created":1554921484000,"modified":1554921484000,"deprecated":false,"name":"Putative neuroblastoma breakpoint family member 8","accession":"Q3BBV2","gene":"NBPF8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.912942858093832,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8920)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(8920)/properties"},"_links":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8920)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(8920)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8920)/publications"},"_namespace":null},{"id":8921,"version":2,"created":1554921484000,"modified":1554921485000,"deprecated":false,"name":"Neuroblastoma breakpoint family member 1","accession":"Q3BBV0","gene":"NBPF1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.32614071841848474,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.272024,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.363175087430875,"pubTatorScore":1.4656306558004084,"self":"https://pharos.nih.gov/idg/api/v1/targets(8921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(8921)/properties"},"_links":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(8921)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8921)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8921)/publications"},"_namespace":null},{"id":8922,"version":3,"created":1554921485000,"modified":1554921569000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 3","accession":"P22001","gene":"KCNA3","description":"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.6910729366059467,"antibodyCount":286,"monoclonalCount":50,"pubmedCount":null,"jensenScore":522.185197,"patentCount":22273,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.24780655321514,"pubTatorScore":2.5262276739278104,"self":"https://pharos.nih.gov/idg/api/v1/targets(8922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(8922)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(8922)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(8922)/synonyms"},"_publications":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(8922)/publications"},"_namespace":null},{"id":8923,"version":2,"created":1554921570000,"modified":1554921571000,"deprecated":false,"name":"Neuroblastoma breakpoint family member 20","accession":"Q3BBV1","gene":"NBPF9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.12493873552256378,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.4,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.531685900537376,"pubTatorScore":0.4873404805005743,"self":"https://pharos.nih.gov/idg/api/v1/targets(8923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(8923)/properties"},"_links":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(8923)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(8923)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8923)/publications"},"_namespace":null},{"id":8924,"version":2,"created":1554921571000,"modified":1554921574000,"deprecated":false,"name":"Bone morphogenetic protein 6","accession":"P22004","gene":"BMP6","description":"Induces cartilage and bone formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5526868911764318,"antibodyCount":317,"monoclonalCount":54,"pubmedCount":null,"jensenScore":373.213387,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.28194062002493,"pubTatorScore":2.285487159158163,"self":"https://pharos.nih.gov/idg/api/v1/targets(8924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(8924)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(8924)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8924)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8924)/publications"},"_namespace":null},{"id":8925,"version":3,"created":1554921576000,"modified":1555038555000,"deprecated":false,"name":"ATP-binding cassette sub-family A member 7","accession":"Q8IZY2","gene":"ABCA7","description":"Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.2028744765957105,"antibodyCount":138,"monoclonalCount":61,"pubmedCount":null,"jensenScore":156.999957,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.22148436841418,"pubTatorScore":1.939522532278357,"self":"https://pharos.nih.gov/idg/api/v1/targets(8925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(8925)/properties"},"_links":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(8925)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(8925)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(8925)/publications"},"_namespace":null},{"id":8926,"version":2,"created":1554921581000,"modified":1554921582000,"deprecated":false,"name":"BH3-like motif-containing cell death inducer","accession":"Q8IZY5","gene":"BLID","description":"Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1376441937759,"antibodyCount":38,"monoclonalCount":18,"pubmedCount":null,"jensenScore":14.1453,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.911485945988307,"pubTatorScore":0.9208187365805955,"self":"https://pharos.nih.gov/idg/api/v1/targets(8926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8926)/properties"},"_links":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(8926)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(8926)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(8926)/publications"},"_namespace":null},{"id":8927,"version":3,"created":1554921582000,"modified":1555038557000,"deprecated":false,"name":"Leukocyte surface antigen CD47","accession":"Q08722","gene":"CD47","description":"Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.728967352191948,"antibodyCount":746,"monoclonalCount":427,"pubmedCount":null,"jensenScore":566.295281,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.32489303325559,"pubTatorScore":2.526151465171764,"self":"https://pharos.nih.gov/idg/api/v1/targets(8927)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":571,"href":"https://pharos.nih.gov/idg/api/v1/targets(8927)/properties"},"_links":{"count":1326,"href":"https://pharos.nih.gov/idg/api/v1/targets(8927)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(8927)/synonyms"},"_publications":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(8927)/publications"},"_namespace":null},{"id":8928,"version":2,"created":1554921589000,"modified":1554921594000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DRB1-3 chain","accession":"P01912","gene":"HLA-DRB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(8928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2714,"href":"https://pharos.nih.gov/idg/api/v1/targets(8928)/properties"},"_links":{"count":1141,"href":"https://pharos.nih.gov/idg/api/v1/targets(8928)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(8928)/synonyms"},"_publications":{"count":2531,"href":"https://pharos.nih.gov/idg/api/v1/targets(8928)/publications"},"_namespace":null},{"id":8929,"version":3,"created":1554921602000,"modified":1555038561000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DRB1-15 beta chain","accession":"P01911","gene":"HLA-DRB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.842576477670612,"antibodyCount":489,"monoclonalCount":327,"pubmedCount":null,"jensenScore":1665.472136,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":41.19227091079068,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(8929)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2736,"href":"https://pharos.nih.gov/idg/api/v1/targets(8929)/properties"},"_links":{"count":1589,"href":"https://pharos.nih.gov/idg/api/v1/targets(8929)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(8929)/synonyms"},"_publications":{"count":2530,"href":"https://pharos.nih.gov/idg/api/v1/targets(8929)/publications"},"_namespace":null},{"id":8930,"version":3,"created":1554921617000,"modified":1555038570000,"deprecated":false,"name":"Protein FAM171B","accession":"Q6P995","gene":"FAM171B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3521825181113625,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.071429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":28.035549097130193,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(8930)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(8930)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8930)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8930)/publications"},"_namespace":null},{"id":8931,"version":2,"created":1554921621000,"modified":1554921623000,"deprecated":false,"name":"Pyridoxal-dependent decarboxylase domain-containing protein 1","accession":"Q6P996","gene":"PDXDC1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.2306608388590409,"antibodyCount":128,"monoclonalCount":6,"pubmedCount":null,"jensenScore":2.379963,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.51627794212459,"pubTatorScore":0.08158743578433802,"self":"https://pharos.nih.gov/idg/api/v1/targets(8931)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(8931)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(8931)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(8931)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(8931)/publications"},"_namespace":null},{"id":8932,"version":3,"created":1554921624000,"modified":1555038571000,"deprecated":false,"name":"V-type proton ATPase subunit e 2","accession":"Q8NHE4","gene":"ATP6V0E2","description":"Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.4,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.384432520870607,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(8932)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(8932)/properties"},"_links":{"count":841,"href":"https://pharos.nih.gov/idg/api/v1/targets(8932)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8932)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8932)/publications"},"_namespace":null},{"id":8933,"version":2,"created":1554921627000,"modified":1554921629000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 1-like","accession":"Q8IZX4","gene":"TAF1L","description":"May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-0.4267435674528732,"antibodyCount":43,"monoclonalCount":24,"pubmedCount":null,"jensenScore":2.715098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.707414754056323,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(8933)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(8933)/properties"},"_links":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(8933)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8933)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8933)/publications"},"_namespace":null},{"id":8934,"version":3,"created":1554921629000,"modified":1555038573000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DQ alpha 1 chain","accession":"P01909","gene":"HLA-DQA1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.901650517511352,"antibodyCount":353,"monoclonalCount":155,"pubmedCount":null,"jensenScore":886.747936,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":40.176675968752434,"pubTatorScore":3.0591635815040212,"self":"https://pharos.nih.gov/idg/api/v1/targets(8934)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(8934)/properties"},"_links":{"count":1107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8934)/links"},"_synonyms":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(8934)/synonyms"},"_publications":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(8934)/publications"},"_namespace":null},{"id":8935,"version":2,"created":1554921638000,"modified":1554921640000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DQ alpha 2 chain","accession":"P01906","gene":"HLA-DQA2","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.260470375140929,"antibodyCount":169,"monoclonalCount":6,"pubmedCount":null,"jensenScore":184.152791,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.89628126746116,"pubTatorScore":1.5711994072834672,"self":"https://pharos.nih.gov/idg/api/v1/targets(8935)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(8935)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(8935)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(8935)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8935)/publications"},"_namespace":null},{"id":8936,"version":3,"created":1554921641000,"modified":1555038575000,"deprecated":false,"name":"CMRF35-like molecule 6","accession":"Q08708","gene":"CD300C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.263854584533968,"antibodyCount":187,"monoclonalCount":53,"pubmedCount":null,"jensenScore":175.695504,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":20.758750230273996,"pubTatorScore":1.7562705538200283,"self":"https://pharos.nih.gov/idg/api/v1/targets(8936)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(8936)/properties"},"_links":{"count":768,"href":"https://pharos.nih.gov/idg/api/v1/targets(8936)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(8936)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8936)/publications"},"_namespace":null},{"id":8937,"version":3,"created":1554921644000,"modified":1555038581000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DR alpha chain","accession":"P01903","gene":"HLA-DRA","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1431907816276228,"antibodyCount":928,"monoclonalCount":736,"pubmedCount":null,"jensenScore":129.555923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":65,"knowledgeAvailability":37.09104941202134,"pubTatorScore":2.103028093513298,"self":"https://pharos.nih.gov/idg/api/v1/targets(8937)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(8937)/properties"},"_links":{"count":1195,"href":"https://pharos.nih.gov/idg/api/v1/targets(8937)/links"},"_synonyms":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(8937)/synonyms"},"_publications":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(8937)/publications"},"_namespace":null},{"id":8938,"version":2,"created":1554921650000,"modified":1554921653000,"deprecated":false,"name":"U11/U12 small nuclear ribonucleoprotein 48 kDa protein","accession":"Q6IEG0","gene":"SNRNP48","description":"Likely involved in U12-type 5' splice site recognition.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.766377988465102,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8938)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(8938)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(8938)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(8938)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8938)/publications"},"_namespace":null},{"id":8939,"version":2,"created":1554921654000,"modified":1554921654000,"deprecated":false,"name":"Putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P","accession":"Q6IED9","gene":"DGAT2L7P","description":"Probable acyltransferase uses fatty acyl-CoA as substrate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.226361370683939,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8939)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8939)/properties"},"_links":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8939)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(8939)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(8939)/publications"},"_namespace":null},{"id":8940,"version":2,"created":1554921654000,"modified":1554921656000,"deprecated":false,"name":"Sodium-dependent neutral amino acid transporter B(0)AT1","accession":"Q695T7","gene":"SLC6A19","description":"Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.896527426567076,"antibodyCount":32,"monoclonalCount":8,"pubmedCount":null,"jensenScore":74.395776,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.48077491379305,"pubTatorScore":1.45879276255866,"self":"https://pharos.nih.gov/idg/api/v1/targets(8940)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(8940)/properties"},"_links":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(8940)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(8940)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8940)/publications"},"_namespace":null},{"id":8941,"version":3,"created":1554921657000,"modified":1555038583000,"deprecated":false,"name":"Tensin-4","accession":"Q8IZW8","gene":"TNS4","description":"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2386135637053448,"antibodyCount":143,"monoclonalCount":41,"pubmedCount":null,"jensenScore":16.068992,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":28.488832471186495,"pubTatorScore":1.4723093931554976,"self":"https://pharos.nih.gov/idg/api/v1/targets(8941)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(8941)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(8941)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8941)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8941)/publications"},"_namespace":null},{"id":8942,"version":2,"created":1554921661000,"modified":1554921662000,"deprecated":false,"name":"Carcinoembryonic antigen-related cell adhesion molecule 16","accession":"Q2WEN9","gene":"CEACAM16","description":"Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.032830464728168,"antibodyCount":74,"monoclonalCount":8,"pubmedCount":null,"jensenScore":11.083406,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.623743916968287,"pubTatorScore":0.9611573046650717,"self":"https://pharos.nih.gov/idg/api/v1/targets(8942)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(8942)/properties"},"_links":{"count":497,"href":"https://pharos.nih.gov/idg/api/v1/targets(8942)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8942)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8942)/publications"},"_namespace":null},{"id":8943,"version":2,"created":1554921663000,"modified":1554921663000,"deprecated":false,"name":"Olfactory receptor 10J5","accession":"Q8NHC4","gene":"OR10J5","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":-0.17609125688420882,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.714286,"patentCount":309,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.536545670703495,"pubTatorScore":1.5129955069053318,"self":"https://pharos.nih.gov/idg/api/v1/targets(8943)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8943)/properties"},"_links":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(8943)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(8943)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8943)/publications"},"_namespace":null},{"id":8944,"version":2,"created":1554921663000,"modified":1554921665000,"deprecated":false,"name":"Transmembrane protein 132E","accession":"Q6IEE7","gene":"TMEM132E","description":"Required for normal inner ear hair cell function and hearing.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.21085336205768454,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.736111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.482478532000275,"pubTatorScore":0.3635222916413859,"self":"https://pharos.nih.gov/idg/api/v1/targets(8944)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(8944)/properties"},"_links":{"count":691,"href":"https://pharos.nih.gov/idg/api/v1/targets(8944)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(8944)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8944)/publications"},"_namespace":null},{"id":8945,"version":2,"created":1554921666000,"modified":1554921667000,"deprecated":false,"name":"Olfactory receptor 14A16","accession":"Q8NHC5","gene":"OR14A16","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":109,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.462521491527221,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(8945)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8945)/properties"},"_links":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8945)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8945)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8945)/publications"},"_namespace":null},{"id":8946,"version":3,"created":1554921667000,"modified":1555038585000,"deprecated":false,"name":"CKLF-like MARVEL transmembrane domain-containing protein 8","accession":"Q8IZV2","gene":"CMTM8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8455924007350978,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.717079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":56,"knowledgeAvailability":32.76016122445827,"pubTatorScore":0.996695814247913,"self":"https://pharos.nih.gov/idg/api/v1/targets(8946)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(8946)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(8946)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(8946)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(8946)/publications"},"_namespace":null},{"id":8947,"version":2,"created":1554921670000,"modified":1554921671000,"deprecated":false,"name":"Olfactory receptor 2T6","accession":"Q8NHC8","gene":"OR2T6","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":90,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.472239730267573,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8947)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8947)/properties"},"_links":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(8947)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8947)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8947)/publications"},"_namespace":null},{"id":8948,"version":2,"created":1554921671000,"modified":1554921671000,"deprecated":false,"name":"Putative olfactory receptor 14L1","accession":"Q8NHC6","gene":"OR14L1P","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.214877554122326,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8948)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8948)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8948)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8948)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8948)/publications"},"_namespace":null},{"id":8949,"version":2,"created":1554921671000,"modified":1554921672000,"deprecated":false,"name":"Olfactory receptor 14C36","accession":"Q8NHC7","gene":"OR14C36","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":53,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.142857,"patentCount":110,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.56390372165694,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(8949)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8949)/properties"},"_links":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8949)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8949)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8949)/publications"},"_namespace":null},{"id":8950,"version":2,"created":1554921672000,"modified":1554921674000,"deprecated":false,"name":"Schlafen family member 12-like","accession":"Q6IEE8","gene":"SLFN12L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.15490196042003768,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.775,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.85204902308342,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8950)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(8950)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(8950)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(8950)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8950)/publications"},"_namespace":null},{"id":8951,"version":2,"created":1554921674000,"modified":1554921677000,"deprecated":false,"name":"Retinol dehydrogenase 10","accession":"Q8IZV5","gene":"RDH10","description":"Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4454385241746963,"antibodyCount":110,"monoclonalCount":2,"pubmedCount":null,"jensenScore":31.278921,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.1910380484951,"pubTatorScore":1.2108215069758022,"self":"https://pharos.nih.gov/idg/api/v1/targets(8951)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(8951)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(8951)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(8951)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(8951)/publications"},"_namespace":null},{"id":8952,"version":2,"created":1554921678000,"modified":1554921681000,"deprecated":false,"name":"RNA-binding protein MEX3A","accession":"A1L020","gene":"MEX3A","description":"RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5854607290742062,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.140116,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.742424724442596,"pubTatorScore":0.062492484022463345,"self":"https://pharos.nih.gov/idg/api/v1/targets(8952)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(8952)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(8952)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(8952)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8952)/publications"},"_namespace":null},{"id":8953,"version":2,"created":1554921681000,"modified":1554921706000,"deprecated":false,"name":"Palmitoleoyl-protein carboxylesterase NOTUM","accession":"Q6P988","gene":"NOTUM","description":"Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.22790870652944,"antibodyCount":137,"monoclonalCount":2,"pubmedCount":null,"jensenScore":161.558135,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.509748057682664,"pubTatorScore":0.7796994977323166,"self":"https://pharos.nih.gov/idg/api/v1/targets(8953)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(8953)/properties"},"_links":{"count":840,"href":"https://pharos.nih.gov/idg/api/v1/targets(8953)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(8953)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8953)/publications"},"_namespace":null},{"id":8954,"version":2,"created":1554921707000,"modified":1554921709000,"deprecated":false,"name":"DNA-binding protein RFX6","accession":"Q8HWS3","gene":"RFX6","description":"Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5772214488283978,"antibodyCount":44,"monoclonalCount":4,"pubmedCount":null,"jensenScore":368.839512,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.00365230918314,"pubTatorScore":1.2595477475776362,"self":"https://pharos.nih.gov/idg/api/v1/targets(8954)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/properties"},"_links":{"count":513,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8954)/publications"},"_namespace":null},{"id":8955,"version":3,"created":1554921710000,"modified":1555038587000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DQ beta 1 chain","accession":"P01920","gene":"HLA-DQB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7599702188874664,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":564.489073,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":38.78213605363618,"pubTatorScore":2.6869148995166747,"self":"https://pharos.nih.gov/idg/api/v1/targets(8955)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1625,"href":"https://pharos.nih.gov/idg/api/v1/targets(8955)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(8955)/links"},"_synonyms":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(8955)/synonyms"},"_publications":{"count":1413,"href":"https://pharos.nih.gov/idg/api/v1/targets(8955)/publications"},"_namespace":null},{"id":8956,"version":2,"created":1554921721000,"modified":1554921724000,"deprecated":false,"name":"Zinc transporter 10","accession":"Q6XR72","gene":"SLC30A10","description":"Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.1037157982527606,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":124.389076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.122675122452442,"pubTatorScore":1.9793547563939877,"self":"https://pharos.nih.gov/idg/api/v1/targets(8956)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(8956)/properties"},"_links":{"count":706,"href":"https://pharos.nih.gov/idg/api/v1/targets(8956)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(8956)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8956)/publications"},"_namespace":null},{"id":8957,"version":2,"created":1554921725000,"modified":1554921726000,"deprecated":false,"name":"Nascent polypeptide-associated complex subunit alpha-2","accession":"Q9H009","gene":"NACA2","description":"Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.7989381492934622,"antibodyCount":27,"monoclonalCount":7,"pubmedCount":null,"jensenScore":58.803124,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.042742991266756,"pubTatorScore":1.9949766604692818,"self":"https://pharos.nih.gov/idg/api/v1/targets(8957)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(8957)/properties"},"_links":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(8957)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(8957)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8957)/publications"},"_namespace":null},{"id":8958,"version":3,"created":1554921727000,"modified":1555038591000,"deprecated":false,"name":"Phospholysine phosphohistidine inorganic pyrophosphate phosphatase","accession":"Q9H008","gene":"LHPP","description":"Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0920727373276706,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.009919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.863439119890366,"pubTatorScore":0.6989700043360189,"self":"https://pharos.nih.gov/idg/api/v1/targets(8958)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(8958)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(8958)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(8958)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8958)/publications"},"_namespace":null},{"id":8959,"version":3,"created":1554921731000,"modified":1554921812000,"deprecated":false,"name":"Beta-3 adrenergic receptor","accession":"P13945","gene":"ADRB3","description":"Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.730900532781104,"antibodyCount":254,"monoclonalCount":4,"pubmedCount":null,"jensenScore":568.373708,"patentCount":13551,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.87223052232092,"pubTatorScore":2.8013016724465456,"self":"https://pharos.nih.gov/idg/api/v1/targets(8959)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(8959)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(8959)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(8959)/synonyms"},"_publications":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(8959)/publications"},"_namespace":null},{"id":8960,"version":2,"created":1554921814000,"modified":1554921818000,"deprecated":false,"name":"Collagen alpha-2(XI) chain","accession":"P13942","gene":"COL11A2","description":"May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8947593317319766,"antibodyCount":143,"monoclonalCount":48,"pubmedCount":null,"jensenScore":73.557837,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.0000226180924,"pubTatorScore":2.609268686825922,"self":"https://pharos.nih.gov/idg/api/v1/targets(8960)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(8960)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(8960)/links"},"_synonyms":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(8960)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8960)/publications"},"_namespace":null},{"id":8961,"version":2,"created":1554921819000,"modified":1554921822000,"deprecated":false,"name":"Probable E3 ubiquitin-protein ligase makorin-2","accession":"Q9H000","gene":"MKRN2","description":"E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4687691742747739,"antibodyCount":211,"monoclonalCount":42,"pubmedCount":null,"jensenScore":3.579816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.06977226048898,"pubTatorScore":0.24948917613282373,"self":"https://pharos.nih.gov/idg/api/v1/targets(8961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8961)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(8961)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(8961)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8961)/publications"},"_namespace":null},{"id":8962,"version":4,"created":1554921823000,"modified":1555038592000,"deprecated":false,"name":"Neuropeptide Y receptor type 1","accession":"P25929","gene":"NPY1R","description":"Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.4109523001913002,"antibodyCount":301,"monoclonalCount":34,"pubmedCount":null,"jensenScore":180.294791,"patentCount":6104,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.952162287922995,"pubTatorScore":1.448976085984794,"self":"https://pharos.nih.gov/idg/api/v1/targets(8962)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/properties"},"_links":{"count":1186,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8962)/publications"},"_namespace":null},{"id":8963,"version":2,"created":1554921934000,"modified":1554921939000,"deprecated":false,"name":"Pyrin","accession":"O15553","gene":"MEFV","description":"Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0273482831786067,"antibodyCount":176,"monoclonalCount":26,"pubmedCount":null,"jensenScore":980.283518,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.653973065938395,"pubTatorScore":3.129971813405471,"self":"https://pharos.nih.gov/idg/api/v1/targets(8963)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":637,"href":"https://pharos.nih.gov/idg/api/v1/targets(8963)/properties"},"_links":{"count":1206,"href":"https://pharos.nih.gov/idg/api/v1/targets(8963)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(8963)/synonyms"},"_publications":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(8963)/publications"},"_namespace":null},{"id":8964,"version":2,"created":1554921940000,"modified":1554921961000,"deprecated":false,"name":"Intermediate conductance calcium-activated potassium channel protein 4","accession":"O15554","gene":"KCNN4","description":"Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.4447325939139617,"antibodyCount":199,"monoclonalCount":4,"pubmedCount":null,"jensenScore":312.266596,"patentCount":12038,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.01452495195336,"pubTatorScore":2.4349423101623,"self":"https://pharos.nih.gov/idg/api/v1/targets(8964)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(8964)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(8964)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(8964)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(8964)/publications"},"_namespace":null},{"id":8965,"version":2,"created":1554921963000,"modified":1554921965000,"deprecated":false,"name":"Proline and serine-rich protein 3","accession":"Q2NL68","gene":"PROSER3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.697179783358594,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8965)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(8965)/properties"},"_links":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(8965)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(8965)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8965)/publications"},"_namespace":null},{"id":8966,"version":2,"created":1554921966000,"modified":1554921969000,"deprecated":false,"name":"Poly [ADP-ribose] polymerase 6","accession":"Q2NL67","gene":"PARP6","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-0.648360013152404,"antibodyCount":137,"monoclonalCount":1,"pubmedCount":null,"jensenScore":4.756706,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.96803812477332,"pubTatorScore":1.4678546438332598,"self":"https://pharos.nih.gov/idg/api/v1/targets(8966)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(8966)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(8966)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(8966)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8966)/publications"},"_namespace":null},{"id":8967,"version":3,"created":1554921970000,"modified":1555038595000,"deprecated":false,"name":"Leukocyte immunoglobulin-like receptor subfamily B member 4","accession":"Q8NHJ6","gene":"LILRB4","description":"Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6284332629222293,"antibodyCount":178,"monoclonalCount":80,"pubmedCount":null,"jensenScore":49.265572,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":31.01374961801732,"pubTatorScore":1.7552797237041637,"self":"https://pharos.nih.gov/idg/api/v1/targets(8967)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(8967)/properties"},"_links":{"count":758,"href":"https://pharos.nih.gov/idg/api/v1/targets(8967)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8967)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(8967)/publications"},"_namespace":null},{"id":8968,"version":3,"created":1554921973000,"modified":1555038596000,"deprecated":false,"name":"Pre-rRNA-processing protein TSR1 homolog","accession":"Q2NL82","gene":"TSR1","description":"Required during maturation of the 40S ribosomal subunit in the nucleolus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.570964816869915,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":32.098265,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":37.64675982324349,"pubTatorScore":1.0495870936664802,"self":"https://pharos.nih.gov/idg/api/v1/targets(8968)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(8968)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(8968)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(8968)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8968)/publications"},"_namespace":null},{"id":8969,"version":2,"created":1554921977000,"modified":1554921978000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 22","accession":"D6RA61","gene":"USP17L22","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.3533600807483954,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8969)/properties"},"_links":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8969)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(8969)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8969)/publications"},"_namespace":null},{"id":8970,"version":2,"created":1554921978000,"modified":1554921982000,"deprecated":false,"name":"Atlastin-2","accession":"Q8NHH9","gene":"ATL2","description":"GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.209410443810293,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.083427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.720928130413775,"pubTatorScore":0.9494838333951968,"self":"https://pharos.nih.gov/idg/api/v1/targets(8970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(8970)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(8970)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(8970)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8970)/publications"},"_namespace":null},{"id":8971,"version":3,"created":1554921983000,"modified":1555038597000,"deprecated":false,"name":"Beta-enolase","accession":"P13929","gene":"ENO3","description":"Appears to have a function in striated muscle development and regeneration.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.40433075621418,"antibodyCount":267,"monoclonalCount":54,"pubmedCount":null,"jensenScore":247.27413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.28282284321435,"pubTatorScore":1.3547685452555793,"self":"https://pharos.nih.gov/idg/api/v1/targets(8971)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(8971)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(8971)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(8971)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8971)/publications"},"_namespace":null},{"id":8972,"version":3,"created":1554921987000,"modified":1555038598000,"deprecated":false,"name":"UPF0561 protein C2orf68","accession":"Q2NKX9","gene":"C2orf68","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4613269904834288,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.950676,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":0.0,"pubTatorScore":0.25794506832079883,"self":"https://pharos.nih.gov/idg/api/v1/targets(8972)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(8972)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(8972)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8972)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8972)/publications"},"_namespace":null},{"id":8973,"version":3,"created":1554921990000,"modified":1555038599000,"deprecated":false,"name":"Annexin A8","accession":"P13928","gene":"ANXA8L1","description":"This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2168347772013315,"antibodyCount":112,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.628435,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.071575169258932,"self":"https://pharos.nih.gov/idg/api/v1/targets(8973)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8973)/properties"},"_links":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(8973)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(8973)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8973)/publications"},"_namespace":null},{"id":8974,"version":3,"created":1554921991000,"modified":1555038600000,"deprecated":false,"name":"Vimentin-type intermediate filament-associated coiled-coil protein","accession":"Q2NL98","gene":"VMAC","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.358569321115708,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":22.392857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":20.93791949790231,"pubTatorScore":0.8750612633917001,"self":"https://pharos.nih.gov/idg/api/v1/targets(8974)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(8974)/properties"},"_links":{"count":756,"href":"https://pharos.nih.gov/idg/api/v1/targets(8974)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(8974)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8974)/publications"},"_namespace":null},{"id":8975,"version":3,"created":1554921993000,"modified":1555038601000,"deprecated":false,"name":"DNA excision repair protein ERCC-6-like","accession":"Q2NKX8","gene":"ERCC6L","description":"DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin (PubMed:17218258). Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.024485476609637,"antibodyCount":150,"monoclonalCount":22,"pubmedCount":null,"jensenScore":110.387315,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.76510091013374,"pubTatorScore":1.3381243305512314,"self":"https://pharos.nih.gov/idg/api/v1/targets(8975)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(8975)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(8975)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(8975)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(8975)/publications"},"_namespace":null},{"id":8976,"version":2,"created":1554921997000,"modified":1554921998000,"deprecated":false,"name":"Uncharacterized protein C3orf84","accession":"H3BNL1","gene":"C3orf84","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8976)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8976)/properties"},"_links":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(8976)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8976)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8976)/publications"},"_namespace":null},{"id":8977,"version":2,"created":1554921998000,"modified":1554922000000,"deprecated":false,"name":"Tubulin polyglutamylase TTLL11","accession":"Q8NHH1","gene":"TTLL11","description":"Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.697123904818675,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(8977)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(8977)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(8977)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(8977)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(8977)/publications"},"_namespace":null},{"id":8978,"version":2,"created":1554922001000,"modified":1554922002000,"deprecated":false,"name":"Sperm acrosome membrane-associated protein 6","accession":"W5XKT8","gene":"SPACA6","description":"Sperm protein potentially involved sperm-egg fusion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(8978)/properties"},"_links":{"count":596,"href":"https://pharos.nih.gov/idg/api/v1/targets(8978)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8978)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(8978)/publications"},"_namespace":null},{"id":8979,"version":2,"created":1554922003000,"modified":1554922005000,"deprecated":false,"name":"E3 ubiquitin-protein ligase ZNRF2","accession":"Q8NHG8","gene":"ZNRF2","description":"May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4101744638482079,"antibodyCount":78,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.960463,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.08371868365184,"pubTatorScore":0.24491386648911212,"self":"https://pharos.nih.gov/idg/api/v1/targets(8979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(8979)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(8979)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8979)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(8979)/publications"},"_namespace":null},{"id":8980,"version":2,"created":1554922006000,"modified":1554922010000,"deprecated":false,"name":"Small VCP/p97-interacting protein","accession":"Q8NHG7","gene":"SVIP","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.611386086393864,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.962543,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.159504962244306,"pubTatorScore":0.769229729506042,"self":"https://pharos.nih.gov/idg/api/v1/targets(8980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(8980)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(8980)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(8980)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(8980)/publications"},"_namespace":null},{"id":8981,"version":3,"created":1554922010000,"modified":1555038602000,"deprecated":false,"name":"KH homology domain-containing protein 1","accession":"Q4VXA5","gene":"KHDC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.22535031372218314,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.259615,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":19.36228828874815,"pubTatorScore":-0.02940954079801761,"self":"https://pharos.nih.gov/idg/api/v1/targets(8981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(8981)/properties"},"_links":{"count":739,"href":"https://pharos.nih.gov/idg/api/v1/targets(8981)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(8981)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8981)/publications"},"_namespace":null},{"id":8982,"version":2,"created":1554922013000,"modified":1554922013000,"deprecated":false,"name":"Uncharacterized protein C6orf229","accession":"H3BNL8","gene":"C6orf229","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8982)/properties"},"_links":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(8982)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(8982)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8982)/publications"},"_namespace":null},{"id":8983,"version":2,"created":1554922014000,"modified":1554922015000,"deprecated":false,"name":"Transmembrane protein 81","accession":"Q6P7N7","gene":"TMEM81","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":6,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.18115305907568,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(8983)/properties"},"_links":{"count":723,"href":"https://pharos.nih.gov/idg/api/v1/targets(8983)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(8983)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(8983)/publications"},"_namespace":null},{"id":8984,"version":2,"created":1554922016000,"modified":1554922018000,"deprecated":false,"name":"Small lysine-rich protein 1","accession":"H3BMG3","gene":"SMKR1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.430854782505122,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(8984)/properties"},"_links":{"count":672,"href":"https://pharos.nih.gov/idg/api/v1/targets(8984)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(8984)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8984)/publications"},"_namespace":null},{"id":8985,"version":2,"created":1554922018000,"modified":1554922020000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 34","accession":"Q8IZ02","gene":"LRRC34","description":"Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.060697839050728224,"antibodyCount":68,"monoclonalCount":4,"pubmedCount":null,"jensenScore":1.605882,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.236271332402733,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(8985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(8985)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(8985)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(8985)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(8985)/publications"},"_namespace":null},{"id":8986,"version":3,"created":1554922021000,"modified":1555038603000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 13A","accession":"Q8IZ07","gene":"ANKRD13A","description":"Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.36797678384694615,"antibodyCount":45,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.258065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.693626720085195,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(8986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(8986)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(8986)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(8986)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(8986)/publications"},"_namespace":null},{"id":8987,"version":3,"created":1554922025000,"modified":1555038604000,"deprecated":false,"name":"TOM1-like protein 2","accession":"Q6ZVM7","gene":"TOM1L2","description":"Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5409593125832616,"antibodyCount":128,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.600798,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.37829619544507,"pubTatorScore":0.4328928419070694,"self":"https://pharos.nih.gov/idg/api/v1/targets(8987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(8987)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(8987)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(8987)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(8987)/publications"},"_namespace":null},{"id":8988,"version":2,"created":1554922029000,"modified":1554922029000,"deprecated":false,"name":"Putative charged multivesicular body protein 4B-like protein CHMP4BP1","accession":"P59074","gene":"CHMP4BP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.588957450348078,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8988)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8988)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8988)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(8988)/publications"},"_namespace":null},{"id":8989,"version":3,"created":1554922029000,"modified":1555038606000,"deprecated":false,"name":"Mothers against decapentaplegic homolog 3","accession":"P84022","gene":"SMAD3","description":"Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.196672645797361,"antibodyCount":1526,"monoclonalCount":281,"pubmedCount":null,"jensenScore":1403.629547,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":63.44267130652003,"pubTatorScore":2.8374426271631186,"self":"https://pharos.nih.gov/idg/api/v1/targets(8989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1248,"href":"https://pharos.nih.gov/idg/api/v1/targets(8989)/properties"},"_links":{"count":1738,"href":"https://pharos.nih.gov/idg/api/v1/targets(8989)/links"},"_synonyms":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(8989)/synonyms"},"_publications":{"count":604,"href":"https://pharos.nih.gov/idg/api/v1/targets(8989)/publications"},"_namespace":null},{"id":8990,"version":3,"created":1554922039000,"modified":1555038610000,"deprecated":false,"name":"Protein transport protein Sec61 subunit gamma","accession":"P60059","gene":"SEC61G","description":"Necessary for protein translocation in the endoplasmic reticulum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3708503927374873,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.27794,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.74597581199512,"pubTatorScore":0.7705890734864956,"self":"https://pharos.nih.gov/idg/api/v1/targets(8990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(8990)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(8990)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(8990)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8990)/publications"},"_namespace":null},{"id":8991,"version":2,"created":1554922043000,"modified":1554922043000,"deprecated":false,"name":"Putative protein KRIP1","accession":"Q107X0","gene":"KLKP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.249210811398565,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(8991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(8991)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(8991)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(8991)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8991)/publications"},"_namespace":null},{"id":8992,"version":2,"created":1554922043000,"modified":1554922046000,"deprecated":false,"name":"F-box DNA helicase 1","accession":"Q8NFZ0","gene":"FBXO18","description":"3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1650733805112135,"antibodyCount":87,"monoclonalCount":8,"pubmedCount":null,"jensenScore":17.682224,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.821057895011286,"pubTatorScore":1.0482937763604343,"self":"https://pharos.nih.gov/idg/api/v1/targets(8992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(8992)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(8992)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(8992)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8992)/publications"},"_namespace":null},{"id":8993,"version":3,"created":1554922046000,"modified":1555038612000,"deprecated":false,"name":"TNFAIP3-interacting protein 2","accession":"Q8NFZ5","gene":"TNIP2","description":"Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.362647385088561,"antibodyCount":160,"monoclonalCount":1,"pubmedCount":null,"jensenScore":22.34972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.669199713037735,"pubTatorScore":1.4466397329570226,"self":"https://pharos.nih.gov/idg/api/v1/targets(8993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(8993)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(8993)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8993)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(8993)/publications"},"_namespace":null},{"id":8994,"version":2,"created":1554922050000,"modified":1554922052000,"deprecated":false,"name":"Vomeronasal type-1 receptor 2","accession":"Q8NFZ6","gene":"VN1R2","description":"Putative pheromone receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":195,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.660802285749295,"pubTatorScore":0.4220736649133789,"self":"https://pharos.nih.gov/idg/api/v1/targets(8994)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(8994)/properties"},"_links":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(8994)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(8994)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(8994)/publications"},"_namespace":null},{"id":8995,"version":2,"created":1554922052000,"modified":1554922055000,"deprecated":false,"name":"Zinc finger protein 100","accession":"Q8IYN0","gene":"ZNF100","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":25,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.760646183602123,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8995)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(8995)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(8995)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(8995)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(8995)/publications"},"_namespace":null},{"id":8996,"version":3,"created":1554922056000,"modified":1555038614000,"deprecated":false,"name":"Neuroligin-4, Y-linked","accession":"Q8NFZ3","gene":"NLGN4Y","description":"Putative neuronal cell surface protein involved in cell-cell-interactions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4286746226805271,"antibodyCount":102,"monoclonalCount":15,"pubmedCount":null,"jensenScore":3.230483,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":19.21714659242654,"pubTatorScore":0.3141013810996377,"self":"https://pharos.nih.gov/idg/api/v1/targets(8996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(8996)/properties"},"_links":{"count":731,"href":"https://pharos.nih.gov/idg/api/v1/targets(8996)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(8996)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8996)/publications"},"_namespace":null},{"id":8997,"version":2,"created":1554922059000,"modified":1554922061000,"deprecated":false,"name":"Transcription elongation factor A protein-like 8","accession":"Q8IYN2","gene":"TCEAL8","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0413926851582251,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.090909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.09797084036898,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(8997)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(8997)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(8997)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(8997)/publications"},"_namespace":null},{"id":8998,"version":2,"created":1554922062000,"modified":1554922065000,"deprecated":false,"name":"Neuroligin-2","accession":"Q8NFZ4","gene":"NLGN2","description":"Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7161560162915632,"antibodyCount":77,"monoclonalCount":0,"pubmedCount":null,"jensenScore":50.387821,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.80209214194301,"pubTatorScore":1.3199153629251246,"self":"https://pharos.nih.gov/idg/api/v1/targets(8998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(8998)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(8998)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(8998)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(8998)/publications"},"_namespace":null},{"id":8999,"version":2,"created":1554922066000,"modified":1554922069000,"deprecated":false,"name":"Desmocollin-1","accession":"Q08554","gene":"DSC1","description":"Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4616073856532323,"antibodyCount":146,"monoclonalCount":35,"pubmedCount":null,"jensenScore":25.053461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.917555513318067,"pubTatorScore":1.646962958863425,"self":"https://pharos.nih.gov/idg/api/v1/targets(8999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(8999)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(8999)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(8999)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(8999)/publications"},"_namespace":null},{"id":9000,"version":2,"created":1554922069000,"modified":1554922071000,"deprecated":false,"name":"UBA-like domain-containing protein 2","accession":"Q8IYN6","gene":"UBALD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.3793813851331,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(9000)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(9000)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(9000)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(9000)/publications"},"_namespace":null}]}