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Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2342741638632195,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.158288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.74868083741357,"pubTatorScore":0.8733574600506908,"self":"https://pharos.nih.gov/idg/api/v1/targets(7070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(7070)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(7070)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(7070)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(7070)/publications"},"_namespace":null},{"id":7071,"version":2,"created":1554906258000,"modified":1554906261000,"deprecated":false,"name":"Draxin","accession":"Q8NBI3","gene":"DRAXIN","description":"Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. 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Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). 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May play an important role in the normal development of the vertebral column (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.033389013318066,"antibodyCount":245,"monoclonalCount":2,"pubmedCount":null,"jensenScore":106.058392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.614081399417547,"pubTatorScore":1.6840142928412818,"self":"https://pharos.nih.gov/idg/api/v1/targets(7083)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/properties"},"_links":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(7083)/publications"},"_namespace":null},{"id":7084,"version":2,"created":1554906341000,"modified":1554906343000,"deprecated":false,"name":"Zinc finger protein 84","accession":"P51523","gene":"ZNF84","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.5795824276334393,"antibodyCount":27,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.236231,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.614047979385607,"pubTatorScore":0.7114556877516415,"self":"https://pharos.nih.gov/idg/api/v1/targets(7084)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(7084)/publications"},"_namespace":null},{"id":7085,"version":2,"created":1554906344000,"modified":1554906346000,"deprecated":false,"name":"Kyphoscoliosis peptidase","accession":"Q8NBH2","gene":"KY","description":"Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.3357921033708414,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.537872280227052,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7085)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(7085)/publications"},"_namespace":null},{"id":7086,"version":3,"created":1554906346000,"modified":1555037302000,"deprecated":false,"name":"Calcitonin","accession":"P01258","gene":"CALCA","description":"Katacalcin is a potent plasma calcium-lowering peptide.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.7035542057936035,"antibodyCount":1309,"monoclonalCount":653,"pubmedCount":null,"jensenScore":8831.255397,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":0.0,"pubTatorScore":3.2813951325409683,"self":"https://pharos.nih.gov/idg/api/v1/targets(7086)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/properties"},"_links":{"count":547,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/synonyms"},"_publications":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(7086)/publications"},"_namespace":null},{"id":7087,"version":3,"created":1554906352000,"modified":1555037304000,"deprecated":false,"name":"NADH-ubiquinone oxidoreductase chain 2","accession":"P03891","gene":"MT-ND2","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.908452621718699,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":775.603588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":8.97191855239277,"pubTatorScore":2.4946564221704794,"self":"https://pharos.nih.gov/idg/api/v1/targets(7087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/links"},"_synonyms":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(7087)/publications"},"_namespace":null},{"id":7088,"version":3,"created":1554906357000,"modified":1555037307000,"deprecated":false,"name":"Troponin C, skeletal muscle","accession":"P02585","gene":"TNNC2","description":"Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8504984721692731,"antibodyCount":102,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.676473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":25.601115586556705,"pubTatorScore":0.9582452359555863,"self":"https://pharos.nih.gov/idg/api/v1/targets(7088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(7088)/publications"},"_namespace":null},{"id":7089,"version":3,"created":1554906360000,"modified":1555037308000,"deprecated":false,"name":"Probable global transcription activator SNF2L2","accession":"P51531","gene":"SMARCA2","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.5743451588977386,"antibodyCount":153,"monoclonalCount":16,"pubmedCount":null,"jensenScore":345.339392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":61.31352944584358,"pubTatorScore":2.0581950922751036,"self":"https://pharos.nih.gov/idg/api/v1/targets(7089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":591,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/properties"},"_links":{"count":1375,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/synonyms"},"_publications":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(7089)/publications"},"_namespace":null},{"id":7090,"version":3,"created":1554906367000,"modified":1555037310000,"deprecated":false,"name":"DNA replication ATP-dependent helicase/nuclease DNA2","accession":"P51530","gene":"DNA2","description":"Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.421593469184617,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":256.063146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":39.00538881427704,"pubTatorScore":2.2179203119453748,"self":"https://pharos.nih.gov/idg/api/v1/targets(7090)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(7090)/publications"},"_namespace":null},{"id":7091,"version":2,"created":1554906373000,"modified":1554906377000,"deprecated":false,"name":"NADH-ubiquinone oxidoreductase chain 3","accession":"P03897","gene":"MT-ND3","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.8291547268286688,"antibodyCount":93,"monoclonalCount":0,"pubmedCount":null,"jensenScore":655.629932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.475154467917231,"pubTatorScore":2.2360802133123254,"self":"https://pharos.nih.gov/idg/api/v1/targets(7091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/links"},"_synonyms":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(7091)/publications"},"_namespace":null},{"id":7092,"version":3,"created":1554906379000,"modified":1555037312000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 8","accession":"P40818","gene":"USP8","description":"Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7296792259610443,"antibodyCount":209,"monoclonalCount":12,"pubmedCount":null,"jensenScore":58.300866,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.64081875258823,"pubTatorScore":1.5704224881831368,"self":"https://pharos.nih.gov/idg/api/v1/targets(7092)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(7092)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(7092)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(7092)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(7092)/publications"},"_namespace":null},{"id":7093,"version":3,"created":1554906385000,"modified":1555037314000,"deprecated":false,"name":"CREB-regulated transcription coactivator 2","accession":"Q53ET0","gene":"CRTC2","description":"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5199118141846097,"antibodyCount":385,"monoclonalCount":64,"pubmedCount":null,"jensenScore":33.968695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.37038458333162,"pubTatorScore":1.8709756502882282,"self":"https://pharos.nih.gov/idg/api/v1/targets(7093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(7093)/publications"},"_namespace":null},{"id":7094,"version":2,"created":1554906388000,"modified":1554906391000,"deprecated":false,"name":"Growth/differentiation factor 6","accession":"Q6KF10","gene":"GDF6","description":"Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.310353783384563,"antibodyCount":110,"monoclonalCount":0,"pubmedCount":null,"jensenScore":205.362909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.545463618843588,"pubTatorScore":2.51841468961661,"self":"https://pharos.nih.gov/idg/api/v1/targets(7094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/properties"},"_links":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(7094)/publications"},"_namespace":null},{"id":7095,"version":3,"created":1554906391000,"modified":1555037316000,"deprecated":false,"name":"Transcription activator BRG1","accession":"P51532","gene":"SMARCA4","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). 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Promotes NHEJ of dysfunctional telomeres (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.03140846338303518,"antibodyCount":98,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.267964,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.47617313097082,"pubTatorScore":2.095591123822264,"self":"https://pharos.nih.gov/idg/api/v1/targets(7192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(7192)/properties"},"_links":{"count":1226,"href":"https://pharos.nih.gov/idg/api/v1/targets(7192)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(7192)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(7192)/publications"},"_namespace":null},{"id":7193,"version":2,"created":1554907111000,"modified":1554907114000,"deprecated":false,"name":"DnaJ homolog subfamily C member 24","accession":"Q6P3W2","gene":"DNAJC24","description":"Stimulates the ATPase activity of several Hsp70-type chaperones. 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Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4033259476132205,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":252.675804,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.268531461780846,"pubTatorScore":1.23636930517484,"self":"https://pharos.nih.gov/idg/api/v1/targets(7304)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(7304)/publications"},"_namespace":null},{"id":7305,"version":2,"created":1554907697000,"modified":1554907701000,"deprecated":false,"name":"HIV Tat-specific factor 1","accession":"O43719","gene":"HTATSF1","description":"Functions as a general transcription factor playing a role in the process of transcriptional elongation. 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Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By 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This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4265113021882585,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":26.07619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.60518428627348,"pubTatorScore":1.1356625808149758,"self":"https://pharos.nih.gov/idg/api/v1/targets(7327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(7327)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(7327)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(7327)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(7327)/publications"},"_namespace":null},{"id":7328,"version":2,"created":1554907884000,"modified":1554907886000,"deprecated":false,"name":"Small integral membrane protein 13","accession":"P0DJ93","gene":"SMIM13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.53725004848302,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(7328)/properties"},"_links":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(7328)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(7328)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(7328)/publications"},"_namespace":null},{"id":7329,"version":2,"created":1554907887000,"modified":1554907889000,"deprecated":false,"name":"Neuronal PAS domain-containing protein 4","accession":"Q8IUM7","gene":"NPAS4","description":"Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8744982399872006,"antibodyCount":112,"monoclonalCount":21,"pubmedCount":null,"jensenScore":80.578997,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.17222145423774,"pubTatorScore":1.3458869534570024,"self":"https://pharos.nih.gov/idg/api/v1/targets(7329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(7329)/properties"},"_links":{"count":728,"href":"https://pharos.nih.gov/idg/api/v1/targets(7329)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(7329)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(7329)/publications"},"_namespace":null},{"id":7330,"version":2,"created":1554907890000,"modified":1554907892000,"deprecated":false,"name":"Coiled-coil domain-containing protein 73","accession":"Q6ZRK6","gene":"CCDC73","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4423591485810879,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.74078326920003,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(7330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(7330)/properties"},"_links":{"count":765,"href":"https://pharos.nih.gov/idg/api/v1/targets(7330)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(7330)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(7330)/publications"},"_namespace":null},{"id":7331,"version":3,"created":1554907893000,"modified":1555037455000,"deprecated":false,"name":"E2F-associated phosphoprotein","accession":"Q56P03","gene":"EAPP","description":"May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. 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Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.381206289739463,"antibodyCount":160,"monoclonalCount":10,"pubmedCount":null,"jensenScore":24.468833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.024105914769773,"pubTatorScore":1.2419354033760226,"self":"https://pharos.nih.gov/idg/api/v1/targets(7336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(7336)/publications"},"_namespace":null},{"id":7337,"version":2,"created":1554907912000,"modified":1554907915000,"deprecated":false,"name":"Cartilage intermediate layer protein 2","accession":"Q8IUL8","gene":"CILP2","description":"May play a role in cartilage scaffolding.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8055148248157916,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.463292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.52487740554821,"pubTatorScore":0.84741846957087,"self":"https://pharos.nih.gov/idg/api/v1/targets(7337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(7337)/publications"},"_namespace":null},{"id":7338,"version":2,"created":1554907915000,"modified":1554907917000,"deprecated":false,"name":"Cerebellin-2","accession":"Q8IUK8","gene":"CBLN2","description":"May play role in synaptogenesis induction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9711708903611765,"antibodyCount":135,"monoclonalCount":5,"pubmedCount":null,"jensenScore":7.772301,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.499156144574304,"pubTatorScore":0.5544313713704123,"self":"https://pharos.nih.gov/idg/api/v1/targets(7338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/properties"},"_links":{"count":599,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(7338)/publications"},"_namespace":null},{"id":7339,"version":3,"created":1554907918000,"modified":1555037459000,"deprecated":false,"name":"Probable 18S rRNA (guanine-N(7))-methyltransferase","accession":"O43709","gene":"BUD23","description":"S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). 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Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8250704676334149,"antibodyCount":115,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":0.9299476255427582,"self":"https://pharos.nih.gov/idg/api/v1/targets(7339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(7339)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(7339)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(7339)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(7339)/publications"},"_namespace":null},{"id":7340,"version":2,"created":1554907921000,"modified":1554907924000,"deprecated":false,"name":"Maleylacetoacetate isomerase","accession":"O43708","gene":"GSTZ1","description":"Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. 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Required for chromatoid body (CB) assembly (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.8467199060318634,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.831504,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.487500344429044,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(7526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/properties"},"_links":{"count":738,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(7526)/publications"},"_namespace":null},{"id":7527,"version":2,"created":1554908687000,"modified":1554908691000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 11","accession":"Q6UB99","gene":"ANKRD11","description":"Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5558802244572036,"antibodyCount":93,"monoclonalCount":11,"pubmedCount":null,"jensenScore":339.66501,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.65892752555374,"pubTatorScore":2.0206951217886604,"self":"https://pharos.nih.gov/idg/api/v1/targets(7527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/properties"},"_links":{"count":1122,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(7527)/publications"},"_namespace":null},{"id":7528,"version":2,"created":1554908692000,"modified":1554908694000,"deprecated":false,"name":"Synaptotagmin-14","accession":"Q8NB59","gene":"SYT14","description":"May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. 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Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.6214276894319406,"antibodyCount":554,"monoclonalCount":221,"pubmedCount":null,"jensenScore":397.933373,"patentCount":70161,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.694175943417434,"pubTatorScore":2.5320733644561417,"self":"https://pharos.nih.gov/idg/api/v1/targets(7529)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/properties"},"_links":{"count":1249,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/synonyms"},"_publications":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(7529)/publications"},"_namespace":null},{"id":7530,"version":2,"created":1554908892000,"modified":1554908900000,"deprecated":false,"name":"Serine/threonine-protein kinase D2","accession":"Q9BZL6","gene":"PRKD2","description":"Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.4620344024579455,"antibodyCount":417,"monoclonalCount":91,"pubmedCount":null,"jensenScore":23.4013,"patentCount":10073,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.340077053494674,"pubTatorScore":1.3961999575493984,"self":"https://pharos.nih.gov/idg/api/v1/targets(7530)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(7530)/publications"},"_namespace":null},{"id":7531,"version":2,"created":1554908901000,"modified":1554908904000,"deprecated":false,"name":"Phospholipid-transporting ATPase IG","accession":"Q8NB49","gene":"ATP11C","description":"Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By 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Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.9048099633879507,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.769727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.2542300160895,"pubTatorScore":0.7978608097508584,"self":"https://pharos.nih.gov/idg/api/v1/targets(7539)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(7539)/publications"},"_namespace":null},{"id":7540,"version":3,"created":1554908928000,"modified":1555037570000,"deprecated":false,"name":"C-C chemokine receptor type 8","accession":"P51685","gene":"CCR8","description":"Receptor for the chemokine CCL1/SCYA1/I-309. 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Alternative coreceptor with CD4 for HIV-1 infection.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.154063340998809,"antibodyCount":412,"monoclonalCount":75,"pubmedCount":null,"jensenScore":145.725363,"patentCount":23134,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.41030788652638,"pubTatorScore":1.9135887394728122,"self":"https://pharos.nih.gov/idg/api/v1/targets(7540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/properties"},"_links":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(7540)/publications"},"_namespace":null},{"id":7541,"version":3,"created":1554908945000,"modified":1555037573000,"deprecated":false,"name":"C-C chemokine receptor type 6","accession":"P51684","gene":"CCR6","description":"Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 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ATP2A2 inhibition is alleviated by PLN phosphorylation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9370061014352202,"antibodyCount":365,"monoclonalCount":27,"pubmedCount":null,"jensenScore":85.849331,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.45505919448654,"pubTatorScore":1.7897515903422132,"self":"https://pharos.nih.gov/idg/api/v1/targets(7730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":460,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(7730)/publications"},"_namespace":null},{"id":7731,"version":3,"created":1554911398000,"modified":1555037763000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 24","accession":"Q9UPU5","gene":"USP24","description":"Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. 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Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. 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Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.364446892244434,"antibodyCount":605,"monoclonalCount":187,"pubmedCount":null,"jensenScore":252.714158,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.53455283641345,"pubTatorScore":2.6214795243437865,"self":"https://pharos.nih.gov/idg/api/v1/targets(7738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/properties"},"_links":{"count":422,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/synonyms"},"_publications":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(7738)/publications"},"_namespace":null},{"id":7739,"version":2,"created":1554911436000,"modified":1554911439000,"deprecated":false,"name":"Homeobox protein Hox-D8","accession":"P13378","gene":"HOXD8","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0660743871062452,"antibodyCount":190,"monoclonalCount":62,"pubmedCount":null,"jensenScore":11.336189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.540554908607728,"pubTatorScore":1.1589246299630405,"self":"https://pharos.nih.gov/idg/api/v1/targets(7739)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/properties"},"_links":{"count":704,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(7739)/publications"},"_namespace":null},{"id":7740,"version":3,"created":1554911439000,"modified":1555037775000,"deprecated":false,"name":"Host cell factor 1","accession":"P51610","gene":"HCFC1","description":"Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5645299125613548,"antibodyCount":172,"monoclonalCount":3,"pubmedCount":null,"jensenScore":370.784514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.3604208028298,"pubTatorScore":3.3649762902060703,"self":"https://pharos.nih.gov/idg/api/v1/targets(7740)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/synonyms"},"_publications":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(7740)/publications"},"_namespace":null},{"id":7741,"version":2,"created":1554911444000,"modified":1554911446000,"deprecated":false,"name":"Cysteine-rich protein 2","accession":"P52943","gene":"CRIP2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0017901983904465,"antibodyCount":143,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.417129,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.445070863530596,"pubTatorScore":1.970306439392441,"self":"https://pharos.nih.gov/idg/api/v1/targets(7741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(7741)/publications"},"_namespace":null},{"id":7742,"version":3,"created":1554911447000,"modified":1555037780000,"deprecated":false,"name":"Cytoplasmic polyadenylation element-binding protein 1","accession":"Q9BZB8","gene":"CPEB1","description":"Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2390605916731126,"antibodyCount":222,"monoclonalCount":3,"pubmedCount":null,"jensenScore":178.761348,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":35.74518627464951,"pubTatorScore":1.8720380411152384,"self":"https://pharos.nih.gov/idg/api/v1/targets(7742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(7742)/publications"},"_namespace":null},{"id":7743,"version":3,"created":1554911452000,"modified":1555037782000,"deprecated":false,"name":"Teratocarcinoma-derived growth factor 1","accession":"P13385","gene":"TDGF1","description":"GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9974615985540143,"antibodyCount":423,"monoclonalCount":109,"pubmedCount":null,"jensenScore":160.367803,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":27.042639450032397,"pubTatorScore":1.8758829351305462,"self":"https://pharos.nih.gov/idg/api/v1/targets(7743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/properties"},"_links":{"count":799,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7743)/publications"},"_namespace":null},{"id":7744,"version":3,"created":1554911455000,"modified":1555037784000,"deprecated":false,"name":"Interleukin-1 receptor-associated kinase 1","accession":"P51617","gene":"IRAK1","description":"Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. 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The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. 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Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.6079963610931194,"antibodyCount":317,"monoclonalCount":66,"pubmedCount":null,"jensenScore":401.385604,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.233640093146022,"pubTatorScore":1.6154821707651217,"self":"https://pharos.nih.gov/idg/api/v1/targets(7822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/properties"},"_links":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(7822)/publications"},"_namespace":null},{"id":7823,"version":3,"created":1554912212000,"modified":1555037827000,"deprecated":false,"name":"F-actin-capping protein subunit alpha-1","accession":"P52907","gene":"CAPZA1","description":"F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. 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Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.842407252796072,"antibodyCount":357,"monoclonalCount":18,"pubmedCount":null,"jensenScore":70.463112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.789099601863356,"pubTatorScore":1.3462275391341636,"self":"https://pharos.nih.gov/idg/api/v1/targets(7899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/properties"},"_links":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(7899)/publications"},"_namespace":null},{"id":7900,"version":3,"created":1554912597000,"modified":1555037900000,"deprecated":false,"name":"S-adenosylhomocysteine hydrolase-like protein 1","accession":"O43865","gene":"AHCYL1","description":"Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.6540703755005843,"antibodyCount":128,"monoclonalCount":33,"pubmedCount":null,"jensenScore":46.170292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":42.44592700315272,"pubTatorScore":1.429146412332185,"self":"https://pharos.nih.gov/idg/api/v1/targets(7900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/properties"},"_links":{"count":1150,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(7900)/publications"},"_namespace":null},{"id":7901,"version":2,"created":1554912603000,"modified":1554912606000,"deprecated":false,"name":"Cytochrome c oxidase subunit 7C, mitochondrial","accession":"P15954","gene":"COX7C","description":"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.0278288320108104,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.085583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.90319669157363,"pubTatorScore":0.47506813175727397,"self":"https://pharos.nih.gov/idg/api/v1/targets(7901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(7901)/publications"},"_namespace":null},{"id":7902,"version":3,"created":1554912607000,"modified":1555037902000,"deprecated":false,"name":"Acylphosphatase-2","accession":"P14621","gene":"ACYP2","description":"Its physiological role is not yet clear.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4080244419664905,"antibodyCount":62,"monoclonalCount":12,"pubmedCount":null,"jensenScore":25.637704,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":37.330112220585534,"pubTatorScore":0.7163014846588348,"self":"https://pharos.nih.gov/idg/api/v1/targets(7902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(7902)/publications"},"_namespace":null},{"id":7903,"version":2,"created":1554912610000,"modified":1554912615000,"deprecated":false,"name":"Fibronectin type III domain-containing protein 3B","accession":"Q53EP0","gene":"FNDC3B","description":"May be a positive regulator of adipogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3812719017053383,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.979298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.495898292282526,"pubTatorScore":0.961458209232899,"self":"https://pharos.nih.gov/idg/api/v1/targets(7903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/properties"},"_links":{"count":980,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(7903)/publications"},"_namespace":null},{"id":7904,"version":3,"created":1554912616000,"modified":1555037903000,"deprecated":false,"name":"Indoleamine 2,3-dioxygenase 2","accession":"Q6ZQW0","gene":"IDO2","description":"Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.966648230767873,"antibodyCount":244,"monoclonalCount":80,"pubmedCount":null,"jensenScore":90.054914,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":19.322298249180562,"pubTatorScore":1.8688146437731492,"self":"https://pharos.nih.gov/idg/api/v1/targets(7904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/properties"},"_links":{"count":479,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(7904)/publications"},"_namespace":null},{"id":7905,"version":3,"created":1554912618000,"modified":1554912714000,"deprecated":false,"name":"Macrophage metalloelastase","accession":"P39900","gene":"MMP12","description":"May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":null,"antibodyCount":447,"monoclonalCount":63,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.709433757209126,"pubTatorScore":2.4479503051459246,"self":"https://pharos.nih.gov/idg/api/v1/targets(7905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/properties"},"_links":{"count":630,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/links"},"_synonyms":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(7905)/publications"},"_namespace":null},{"id":7906,"version":2,"created":1554912716000,"modified":1554912716000,"deprecated":false,"name":"Olfactory receptor 2T1","accession":"O43869","gene":"OR2T1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":336,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.687006775234671,"pubTatorScore":1.5200466079834543,"self":"https://pharos.nih.gov/idg/api/v1/targets(7906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/properties"},"_links":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(7906)/publications"},"_namespace":null},{"id":7907,"version":2,"created":1554912717000,"modified":1554912719000,"deprecated":false,"name":"Otoancorin","accession":"Q7RTW8","gene":"OTOA","description":"May act as an adhesion molecule.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3147121347393331,"antibodyCount":58,"monoclonalCount":2,"pubmedCount":null,"jensenScore":20.407249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.275148291692467,"pubTatorScore":0.7793559034007393,"self":"https://pharos.nih.gov/idg/api/v1/targets(7907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/properties"},"_links":{"count":707,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(7907)/publications"},"_namespace":null},{"id":7908,"version":2,"created":1554912719000,"modified":1554912723000,"deprecated":false,"name":"Sodium/nucleoside cotransporter 2","accession":"O43868","gene":"SLC28A2","description":"Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.8786979202500227,"antibodyCount":122,"monoclonalCount":8,"pubmedCount":null,"jensenScore":73.175782,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.35909516276787,"pubTatorScore":1.7555505833353395,"self":"https://pharos.nih.gov/idg/api/v1/targets(7908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(7908)/publications"},"_namespace":null},{"id":7909,"version":3,"created":1554912724000,"modified":1555037904000,"deprecated":false,"name":"Uncharacterized protein C16orf46","accession":"Q6P387","gene":"C16orf46","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(7909)/publications"},"_namespace":null},{"id":7910,"version":3,"created":1554912727000,"modified":1555037907000,"deprecated":false,"name":"Apolipoprotein C-III","accession":"P02656","gene":"APOC3","description":"Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9334802697065845,"antibodyCount":267,"monoclonalCount":32,"pubmedCount":null,"jensenScore":875.184782,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":29.630276808634918,"pubTatorScore":2.8314177801500366,"self":"https://pharos.nih.gov/idg/api/v1/targets(7910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":651,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/synonyms"},"_publications":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(7910)/publications"},"_namespace":null},{"id":7911,"version":3,"created":1554912733000,"modified":1555037910000,"deprecated":false,"name":"Apolipoprotein C-II","accession":"P02655","gene":"APOC2","description":"Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5108616915720785,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":342.659955,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.070775621743326,"pubTatorScore":2.5184376486935918,"self":"https://pharos.nih.gov/idg/api/v1/targets(7911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/properties"},"_links":{"count":755,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(7911)/publications"},"_namespace":null},{"id":7912,"version":2,"created":1554912736000,"modified":1554912740000,"deprecated":false,"name":"Apolipoprotein C-I","accession":"P02654","gene":"APOC1","description":"Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. 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Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. 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The formation of this structure appears to drive apposition and subsequent fusion of membranes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.65033401590337,"antibodyCount":184,"monoclonalCount":19,"pubmedCount":null,"jensenScore":4159.37904,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.69700714802079,"pubTatorScore":1.6798819421128623,"self":"https://pharos.nih.gov/idg/api/v1/targets(7983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(7983)/publications"},"_namespace":null},{"id":7984,"version":2,"created":1554912987000,"modified":1554912990000,"deprecated":false,"name":"Magnesium transporter NIPA1","accession":"Q7RTP0","gene":"NIPA1","description":"Acts as a Mg(2+) transporter. 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Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.855432018879203,"antibodyCount":180,"monoclonalCount":9,"pubmedCount":null,"jensenScore":697.433929,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":42.57331945115158,"pubTatorScore":2.741023364525427,"self":"https://pharos.nih.gov/idg/api/v1/targets(7987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(7987)/publications"},"_namespace":null},{"id":7988,"version":2,"created":1554913001000,"modified":1554913001000,"deprecated":false,"name":"Putative uncharacterized protein PNAS-138","accession":"Q9BZS9","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(7988)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(7988)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(7988)/synonyms"},"_publications":null,"_namespace":null},{"id":7989,"version":2,"created":1554913001000,"modified":1554913003000,"deprecated":false,"name":"Uncharacterized protein C22orf46","accession":"C9J442","gene":"C22orf46","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(7989)/publications"},"_namespace":null},{"id":7990,"version":3,"created":1554913004000,"modified":1555037938000,"deprecated":false,"name":"Forkhead box protein P3","accession":"Q9BZS1","gene":"FOXP3","description":"Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). 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Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.80046421880166,"antibodyCount":1358,"monoclonalCount":674,"pubmedCount":null,"jensenScore":6233.752801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.40461240001423,"pubTatorScore":3.39771390058705,"self":"https://pharos.nih.gov/idg/api/v1/targets(7990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1160,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/properties"},"_links":{"count":1675,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/synonyms"},"_publications":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(7990)/publications"},"_namespace":null},{"id":7991,"version":2,"created":1554913015000,"modified":1554913015000,"deprecated":false,"name":"Endogenous retrovirus group K member 11 Pol protein","accession":"Q9UQG0","gene":"ERVK-11","description":"Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(7991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(7991)/publications"},"_namespace":null},{"id":7992,"version":2,"created":1554913015000,"modified":1554913017000,"deprecated":false,"name":"Forkhead box protein I2","accession":"Q6ZQN5","gene":"FOXI2","description":"Possible transcriptional activator.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.7783877272979401,"antibodyCount":70,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.224426,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.199020197786773,"pubTatorScore":-0.40654002843091314,"self":"https://pharos.nih.gov/idg/api/v1/targets(7992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/properties"},"_links":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(7992)/publications"},"_namespace":null},{"id":7993,"version":3,"created":1554913017000,"modified":1555037943000,"deprecated":false,"name":"Tubulin alpha-1A chain","accession":"Q71U36","gene":"TUBA1A","description":"Tubulin is the major constituent of microtubules. 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May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.4603180689520618,"antibodyCount":58,"monoclonalCount":2,"pubmedCount":null,"jensenScore":28.356557,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.564051797325327,"pubTatorScore":0.9307646841902517,"self":"https://pharos.nih.gov/idg/api/v1/targets(7996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(7996)/publications"},"_namespace":null},{"id":7997,"version":3,"created":1554913035000,"modified":1555037946000,"deprecated":false,"name":"Reticulon-4 receptor","accession":"Q9BZR6","gene":"RTN4R","description":"Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6019974574249014,"antibodyCount":232,"monoclonalCount":59,"pubmedCount":null,"jensenScore":411.784745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.6509276537615,"pubTatorScore":2.1477842538722394,"self":"https://pharos.nih.gov/idg/api/v1/targets(7997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(7997)/publications"},"_namespace":null},{"id":7998,"version":3,"created":1554913039000,"modified":1555037947000,"deprecated":false,"name":"Toll-interacting protein","accession":"Q9H0E2","gene":"TOLLIP","description":"Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8754370906872955,"antibodyCount":423,"monoclonalCount":136,"pubmedCount":null,"jensenScore":81.575101,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.20034924316368,"pubTatorScore":1.6888769432708757,"self":"https://pharos.nih.gov/idg/api/v1/targets(7998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/properties"},"_links":{"count":1142,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(7998)/publications"},"_namespace":null},{"id":7999,"version":3,"created":1554913044000,"modified":1555037949000,"deprecated":false,"name":"Regenerating islet-derived protein 3-alpha","accession":"Q06141","gene":"REG3A","description":"Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.617901872664404,"antibodyCount":321,"monoclonalCount":37,"pubmedCount":null,"jensenScore":412.969734,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":20.673581057803997,"pubTatorScore":3.214263250113781,"self":"https://pharos.nih.gov/idg/api/v1/targets(7999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/properties"},"_links":{"count":606,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(7999)/publications"},"_namespace":null},{"id":8000,"version":2,"created":1554913047000,"modified":1554913047000,"deprecated":false,"name":"Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23","accession":"D6RBM5","gene":"USP17L23","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(8000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/properties"},"_links":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(8000)/publications"},"_namespace":null}]}