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Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. 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For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. 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Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.681385794634827,"antibodyCount":620,"monoclonalCount":225,"pubmedCount":null,"jensenScore":387.569668,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":46.2932372515818,"pubTatorScore":2.5857659008278064,"self":"https://pharos.nih.gov/idg/api/v1/targets(6079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":645,"href":"https://pharos.nih.gov/idg/api/v1/targets(6079)/properties"},"_links":{"count":1089,"href":"https://pharos.nih.gov/idg/api/v1/targets(6079)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(6079)/synonyms"},"_publications":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(6079)/publications"},"_namespace":null},{"id":6080,"version":2,"created":1554899171000,"modified":1554899176000,"deprecated":false,"name":"Collagen alpha-3(VI) chain","accession":"P12111","gene":"COL6A3","description":"Collagen VI acts as a cell-binding protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7968661702981696,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":61.255439,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.46885276569077,"pubTatorScore":1.7145370565349516,"self":"https://pharos.nih.gov/idg/api/v1/targets(6080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(6080)/properties"},"_links":{"count":1225,"href":"https://pharos.nih.gov/idg/api/v1/targets(6080)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(6080)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(6080)/publications"},"_namespace":null},{"id":6081,"version":3,"created":1554899177000,"modified":1555036658000,"deprecated":false,"name":"Transcription factor E4F1","accession":"Q66K89","gene":"E4F1","description":"Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4726520309855646,"antibodyCount":87,"monoclonalCount":13,"pubmedCount":null,"jensenScore":33.647692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":56,"knowledgeAvailability":35.82523466346755,"pubTatorScore":1.4618092347996265,"self":"https://pharos.nih.gov/idg/api/v1/targets(6081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(6081)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(6081)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(6081)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(6081)/publications"},"_namespace":null},{"id":6082,"version":4,"created":1554899180000,"modified":1555036661000,"deprecated":false,"name":"Matrix metalloproteinase-9","accession":"P14780","gene":"MMP9","description":"May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.316013232317847,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6096)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(6096)/properties"},"_links":{"count":582,"href":"https://pharos.nih.gov/idg/api/v1/targets(6096)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(6096)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(6096)/publications"},"_namespace":null},{"id":6097,"version":2,"created":1554899867000,"modified":1554899867000,"deprecated":false,"name":"Immunoglobulin kappa variable 3D-11","accession":"A0A0A0MRZ8","gene":"IGKV3D-11","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). 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May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.465973893943865,"antibodyCount":397,"monoclonalCount":227,"pubmedCount":null,"jensenScore":2968.776432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":31.407170062589422,"pubTatorScore":3.2544595164743693,"self":"https://pharos.nih.gov/idg/api/v1/targets(6112)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/synonyms"},"_publications":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(6112)/publications"},"_namespace":null},{"id":6113,"version":3,"created":1554899925000,"modified":1555036698000,"deprecated":false,"name":"60S ribosomal protein L18","accession":"Q07020","gene":"RPL18","description":"Component of the large ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4598366401952372,"antibodyCount":149,"monoclonalCount":10,"pubmedCount":null,"jensenScore":25.754147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":85,"knowledgeAvailability":40.50935474370922,"pubTatorScore":1.4066160816639504,"self":"https://pharos.nih.gov/idg/api/v1/targets(6113)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(6113)/publications"},"_namespace":null},{"id":6114,"version":2,"created":1554899930000,"modified":1554899933000,"deprecated":false,"name":"Complement component 1 Q subcomponent-binding protein, mitochondrial","accession":"Q07021","gene":"C1QBP","description":"Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular \"heads\" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. Involved in replication of Rubella virus. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppresion of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5504629788711766,"antibodyCount":353,"monoclonalCount":119,"pubmedCount":null,"jensenScore":348.622396,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.83924157128223,"pubTatorScore":2.2760334222678584,"self":"https://pharos.nih.gov/idg/api/v1/targets(6114)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":580,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/properties"},"_links":{"count":1201,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(6114)/publications"},"_namespace":null},{"id":6115,"version":3,"created":1554899934000,"modified":1555036701000,"deprecated":false,"name":"Histone H3-like centromeric protein A","accession":"P49450","gene":"CENPA","description":"Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). 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Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7332228371185114,"antibodyCount":386,"monoclonalCount":104,"pubmedCount":null,"jensenScore":566.969484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.03837313306772,"pubTatorScore":2.514625104641919,"self":"https://pharos.nih.gov/idg/api/v1/targets(6115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(6115)/publications"},"_namespace":null},{"id":6116,"version":2,"created":1554899939000,"modified":1554899943000,"deprecated":false,"name":"Centromere protein F","accession":"P49454","gene":"CENPF","description":"Required for kinetochore function and chromosome segregation in mitosis. 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Involved in dendritic cell regulation of T-cell immunity against chlamydia.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.029393275809391,"antibodyCount":186,"monoclonalCount":33,"pubmedCount":null,"jensenScore":109.085448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.805612529294685,"pubTatorScore":1.9749344059562497,"self":"https://pharos.nih.gov/idg/api/v1/targets(6116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(6116)/publications"},"_namespace":null},{"id":6117,"version":2,"created":1554899944000,"modified":1554899948000,"deprecated":false,"name":"Sodium-dependent phosphate transporter 2","accession":"Q08357","gene":"SLC20A2","description":"Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. 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Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) 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Involved in neurotrophin-induced neurite outgrowth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6122660782384566,"antibodyCount":183,"monoclonalCount":20,"pubmedCount":null,"jensenScore":41.981686,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.09358216195583,"pubTatorScore":1.6163746849483234,"self":"https://pharos.nih.gov/idg/api/v1/targets(6153)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(6153)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(6153)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(6153)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(6153)/publications"},"_namespace":null},{"id":6154,"version":2,"created":1554900831000,"modified":1554900834000,"deprecated":false,"name":"ERC protein 2","accession":"O15083","gene":"ERC2","description":"Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. 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Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.2288823402843336,"antibodyCount":272,"monoclonalCount":5,"pubmedCount":null,"jensenScore":174.188437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.82205498045045,"pubTatorScore":1.8326146377692631,"self":"https://pharos.nih.gov/idg/api/v1/targets(6230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(6230)/publications"},"_namespace":null},{"id":6231,"version":3,"created":1554901135000,"modified":1555036783000,"deprecated":false,"name":"Period circadian protein homolog 2","accession":"O15055","gene":"PER2","description":"Transcriptional repressor which forms a core component of the circadian clock. 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The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. 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FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.544999736089638,"antibodyCount":369,"monoclonalCount":72,"pubmedCount":null,"jensenScore":414.87495,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.857569621404767,"pubTatorScore":2.5859520919690984,"self":"https://pharos.nih.gov/idg/api/v1/targets(6232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/properties"},"_links":{"count":666,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/synonyms"},"_publications":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(6232)/publications"},"_namespace":null},{"id":6233,"version":2,"created":1554901158000,"modified":1554901165000,"deprecated":false,"name":"Collagen alpha-1(XI) chain","accession":"P12107","gene":"COL11A1","description":"May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1551644772626615,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":138.365109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.00058717698813,"pubTatorScore":1.9880810949935024,"self":"https://pharos.nih.gov/idg/api/v1/targets(6233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(6233)/publications"},"_namespace":null},{"id":6234,"version":2,"created":1554901166000,"modified":1554901170000,"deprecated":false,"name":"Lipoma-preferred partner","accession":"Q93052","gene":"LPP","description":"May play a structural role at sites of cell adhesion in maintaining cell shape and motility. 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Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7794891990315715,"antibodyCount":164,"monoclonalCount":49,"pubmedCount":null,"jensenScore":582.593297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.874140679759776,"pubTatorScore":1.6565088618802581,"self":"https://pharos.nih.gov/idg/api/v1/targets(6234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/properties"},"_links":{"count":1137,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(6234)/publications"},"_namespace":null},{"id":6235,"version":2,"created":1554901172000,"modified":1554901176000,"deprecated":false,"name":"Collagen alpha-2(VI) chain","accession":"P12110","gene":"COL6A2","description":"Collagen VI acts as a cell-binding protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8053053176660012,"antibodyCount":151,"monoclonalCount":17,"pubmedCount":null,"jensenScore":59.19986,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.160002608733954,"pubTatorScore":1.746710489526803,"self":"https://pharos.nih.gov/idg/api/v1/targets(6235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/properties"},"_links":{"count":1215,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(6235)/publications"},"_namespace":null},{"id":6236,"version":3,"created":1554901177000,"modified":1555036786000,"deprecated":false,"name":"V-type proton ATPase 116 kDa subunit a isoform 1","accession":"Q93050","gene":"ATP6V0A1","description":"Required for assembly and activity of the vacuolar ATPase. 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The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2482583569824093,"antibodyCount":343,"monoclonalCount":220,"pubmedCount":null,"jensenScore":167.599696,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":25.691397392598127,"pubTatorScore":2.085588176723918,"self":"https://pharos.nih.gov/idg/api/v1/targets(6237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/properties"},"_links":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(6237)/publications"},"_namespace":null},{"id":6238,"version":2,"created":1554901184000,"modified":1554901187000,"deprecated":false,"name":"NEDD4-binding protein 3","accession":"O15049","gene":"N4BP3","description":"Plays a role in axon and dendrite arborization during cranial nerve development. 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Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). 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Not involved in glycosylation of erythropoietin (EPO).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6699602258968655,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.390584,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.05040600822066,"pubTatorScore":0.735826924262557,"self":"https://pharos.nih.gov/idg/api/v1/targets(6501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(6501)/publications"},"_namespace":null},{"id":6502,"version":2,"created":1554902360000,"modified":1554902362000,"deprecated":false,"name":"SLAIN motif-containing 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.648631362283689,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(6543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/properties"},"_links":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(6543)/publications"},"_namespace":null},{"id":6544,"version":2,"created":1554902547000,"modified":1554902548000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-39","accession":"P01597","gene":"IGKV1-39","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2035081996554204,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/properties"},"_links":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(6544)/publications"},"_namespace":null},{"id":6545,"version":2,"created":1554902548000,"modified":1554902548000,"deprecated":false,"name":"Putative uncharacterized protein SERTAD4-AS1","accession":"Q5TG53","gene":"SERTAD4-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.24271481131519,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6545)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(6545)/publications"},"_namespace":null},{"id":6546,"version":2,"created":1554902548000,"modified":1554902549000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-33","accession":"P01594","gene":"IGKV1-33","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). 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ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.21263801451622,"antibodyCount":618,"monoclonalCount":334,"pubmedCount":null,"jensenScore":144.704061,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":32.07070666937967,"pubTatorScore":2.071528439725327,"self":"https://pharos.nih.gov/idg/api/v1/targets(6558)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(6558)/publications"},"_namespace":null},{"id":6559,"version":3,"created":1554903227000,"modified":1555036992000,"deprecated":false,"name":"Protein Hikeshi","accession":"Q53FT3","gene":"HIKESHI","description":"Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.029045397407043,"antibodyCount":121,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.605356,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":0.8314431375003237,"self":"https://pharos.nih.gov/idg/api/v1/targets(6559)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(6559)/publications"},"_namespace":null},{"id":6560,"version":2,"created":1554903230000,"modified":1554903235000,"deprecated":false,"name":"Peroxisomal targeting signal 1 receptor","accession":"P50542","gene":"PEX5","description":"Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4312575052995067,"antibodyCount":138,"monoclonalCount":39,"pubmedCount":null,"jensenScore":272.807349,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.49445066000761,"pubTatorScore":2.1082143923755186,"self":"https://pharos.nih.gov/idg/api/v1/targets(6560)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/properties"},"_links":{"count":1433,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/links"},"_synonyms":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(6560)/publications"},"_namespace":null},{"id":6561,"version":4,"created":1554903237000,"modified":1555036994000,"deprecated":false,"name":"Inosine-5'-monophosphate dehydrogenase 2","accession":"P12268","gene":"IMPDH2","description":"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.980401474138919,"antibodyCount":247,"monoclonalCount":15,"pubmedCount":null,"jensenScore":94.340503,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":44.41236132409953,"pubTatorScore":1.9216572545436994,"self":"https://pharos.nih.gov/idg/api/v1/targets(6561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/properties"},"_links":{"count":1597,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(6561)/publications"},"_namespace":null},{"id":6562,"version":2,"created":1554903404000,"modified":1554903407000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF8","accession":"O76064","gene":"RNF8","description":"E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (PubMed:23233665). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. 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This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.35295951414504,"antibodyCount":122,"monoclonalCount":21,"pubmedCount":null,"jensenScore":2270.409413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.90068017001074,"pubTatorScore":3.2190546637674053,"self":"https://pharos.nih.gov/idg/api/v1/targets(6564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":474,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/properties"},"_links":{"count":2237,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/links"},"_synonyms":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(6564)/publications"},"_namespace":null},{"id":6565,"version":2,"created":1554903774000,"modified":1554903778000,"deprecated":false,"name":"Parathyroid hormone-related protein","accession":"P12272","gene":"PTHLH","description":"Osteostatin is a potent inhibitor of osteoclastic bone resorption.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.276757833301795,"antibodyCount":283,"monoclonalCount":50,"pubmedCount":null,"jensenScore":2151.492775,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.84401001820878,"pubTatorScore":3.1434772469216337,"self":"https://pharos.nih.gov/idg/api/v1/targets(6565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":585,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/synonyms"},"_publications":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(6565)/publications"},"_namespace":null},{"id":6566,"version":2,"created":1554903781000,"modified":1554903783000,"deprecated":false,"name":"Probable cytosolic iron-sulfur protein assembly protein CIAO1","accession":"O76071","gene":"CIAO1","description":"Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. 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Activates the MAPK and Elk-1 signal transduction pathway (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2489473425915136,"antibodyCount":294,"monoclonalCount":54,"pubmedCount":null,"jensenScore":187.345177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.06129016231813,"pubTatorScore":2.0162368524310503,"self":"https://pharos.nih.gov/idg/api/v1/targets(6568)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(6568)/publications"},"_namespace":null},{"id":6569,"version":3,"created":1554903789000,"modified":1555037004000,"deprecated":false,"name":"Chitinase-3-like protein 1","accession":"P36222","gene":"CHI3L1","description":"Carbohydrate-binding lectin with a preference for chitin. 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Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.82180030085194,"antibodyCount":299,"monoclonalCount":80,"pubmedCount":null,"jensenScore":732.923424,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.02047921641284,"pubTatorScore":2.824143272410676,"self":"https://pharos.nih.gov/idg/api/v1/targets(6569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":603,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/properties"},"_links":{"count":1258,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/synonyms"},"_publications":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(6569)/publications"},"_namespace":null},{"id":6570,"version":2,"created":1554903795000,"modified":1554903798000,"deprecated":false,"name":"Retinaldehyde-binding protein 1","accession":"P12271","gene":"RLBP1","description":"Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. 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The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1496423694359628,"antibodyCount":108,"monoclonalCount":65,"pubmedCount":null,"jensenScore":143.368044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.50904052974142,"pubTatorScore":2.0119436453624466,"self":"https://pharos.nih.gov/idg/api/v1/targets(6570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/properties"},"_links":{"count":677,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(6570)/publications"},"_namespace":null},{"id":6571,"version":2,"created":1554903798000,"modified":1554903800000,"deprecated":false,"name":"Zinc finger protein 485","accession":"Q8NCK3","gene":"ZNF485","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":55,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.12479086734316,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(6571)/publications"},"_namespace":null},{"id":6572,"version":2,"created":1554903801000,"modified":1554903805000,"deprecated":false,"name":"Nucleoprotein TPR","accession":"P12270","gene":"TPR","description":"Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.114912562249106,"antibodyCount":161,"monoclonalCount":39,"pubmedCount":null,"jensenScore":135.63141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.21468307353099,"pubTatorScore":2.486023717944981,"self":"https://pharos.nih.gov/idg/api/v1/targets(6572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":599,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(6572)/publications"},"_namespace":null},{"id":6573,"version":3,"created":1554903807000,"modified":1555037006000,"deprecated":false,"name":"Monocarboxylate transporter 11","accession":"Q8NCK7","gene":"SLC16A11","description":"Proton-linked monocarboxylate transporter. 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Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.8378739024209555,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.352328,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":20.123539891901178,"pubTatorScore":0.7999965278181024,"self":"https://pharos.nih.gov/idg/api/v1/targets(6573)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(6573)/publications"},"_namespace":null},{"id":6574,"version":3,"created":1554903809000,"modified":1555037007000,"deprecated":false,"name":"Interleukin-2 receptor subunit alpha","accession":"P01589","gene":"IL2RA","description":"Receptor for interleukin-2. 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Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. 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The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.8408004885822902,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":66.240306,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.0903524260337,"pubTatorScore":2.163887917855051,"self":"https://pharos.nih.gov/idg/api/v1/targets(6734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(6734)/publications"},"_namespace":null},{"id":6735,"version":2,"created":1554904397000,"modified":1554904399000,"deprecated":false,"name":"Uncharacterized protein C1orf131","accession":"Q8NDD1","gene":"C1orf131","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(6735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(6735)/publications"},"_namespace":null},{"id":6736,"version":2,"created":1554904399000,"modified":1554904403000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 17","accession":"Q8IVW1","gene":"ARL17A","description":"GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. 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Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth 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Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1. Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). 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May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. 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