{"id":327290,"version":1,"created":1584652195924,"modified":1584652195931,"deprecated":false,"etag":"c5aab5ce08472b51","uri":"https://pharos.nih.gov/idg/api/v1/targets?top=1000&skip=3000","path":"/idg/api/v1/targets","method":"GET","sha1":"97018d676813cb41bf1f03d84edfcc589327cc0f","total":20244,"count":1000,"skip":3000,"top":1000,"status":null,"query":"skip=3000&top=1000","filter":null,"_namespace":null,"content":[{"id":3001,"version":2,"created":1554875595000,"modified":1554875597000,"deprecated":false,"name":"Junction-mediating and -regulatory protein","accession":"Q8N9B5","gene":"JMY","description":"Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2675985998783523,"antibodyCount":162,"monoclonalCount":38,"pubmedCount":null,"jensenScore":21.199856,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.23119018034973,"pubTatorScore":1.1147776986284144,"self":"https://pharos.nih.gov/idg/api/v1/targets(3001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3001)/publications"},"_namespace":null},{"id":3002,"version":2,"created":1554875598000,"modified":1554875600000,"deprecated":false,"name":"Calcium-regulated heat-stable protein 1","accession":"Q9Y2V2","gene":"CARHSP1","description":"Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.4607785623963136,"antibodyCount":54,"monoclonalCount":6,"pubmedCount":null,"jensenScore":3.366024,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.52887379405742,"pubTatorScore":0.6973762629261323,"self":"https://pharos.nih.gov/idg/api/v1/targets(3002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(3002)/properties"},"_links":{"count":1093,"href":"https://pharos.nih.gov/idg/api/v1/targets(3002)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(3002)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3002)/publications"},"_namespace":null},{"id":3003,"version":2,"created":1554875601000,"modified":1554875604000,"deprecated":false,"name":"Endophilin-B1","accession":"Q9Y371","gene":"SH3GLB1","description":"May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.100958315543623,"antibodyCount":386,"monoclonalCount":83,"pubmedCount":null,"jensenScore":14.476774,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.9997592452936,"pubTatorScore":1.342431188962579,"self":"https://pharos.nih.gov/idg/api/v1/targets(3003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(3003)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3003)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3003)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3003)/publications"},"_namespace":null},{"id":3004,"version":2,"created":1554875605000,"modified":1554875607000,"deprecated":false,"name":"Ras-GEF domain-containing family member 1A","accession":"Q8N9B8","gene":"RASGEF1A","description":"Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5659553598265951,"antibodyCount":50,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.214486,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.41205307853898,"pubTatorScore":0.5581604378661815,"self":"https://pharos.nih.gov/idg/api/v1/targets(3004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(3004)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(3004)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3004)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3004)/publications"},"_namespace":null},{"id":3005,"version":2,"created":1554875608000,"modified":1554875610000,"deprecated":false,"name":"Folate receptor gamma","accession":"P41439","gene":"FOLR3","description":"Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8204693496098486,"antibodyCount":98,"monoclonalCount":9,"pubmedCount":null,"jensenScore":6.262867,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.88168270428415,"pubTatorScore":0.9606640978162939,"self":"https://pharos.nih.gov/idg/api/v1/targets(3005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3005)/properties"},"_links":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(3005)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3005)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3005)/publications"},"_namespace":null},{"id":3006,"version":2,"created":1554875610000,"modified":1554875611000,"deprecated":false,"name":"Retinal homeobox protein Rx","accession":"Q9Y2V3","gene":"RAX","description":"Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.5255400164668858,"antibodyCount":205,"monoclonalCount":136,"pubmedCount":null,"jensenScore":4.681161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.894445343194633,"pubTatorScore":1.6463111420256784,"self":"https://pharos.nih.gov/idg/api/v1/targets(3006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(3006)/properties"},"_links":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(3006)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3006)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3006)/publications"},"_namespace":null},{"id":3007,"version":3,"created":1554875611000,"modified":1555034469000,"deprecated":false,"name":"RPA-interacting protein","accession":"Q86UA6","gene":"RPAIN","description":"Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4121804188336833,"antibodyCount":153,"monoclonalCount":11,"pubmedCount":null,"jensenScore":24.112849,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.86572944550131,"pubTatorScore":1.2240147595168034,"self":"https://pharos.nih.gov/idg/api/v1/targets(3007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(3007)/properties"},"_links":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(3007)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3007)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3007)/publications"},"_namespace":null},{"id":3008,"version":3,"created":1554875615000,"modified":1555034470000,"deprecated":false,"name":"Uncharacterized protein C15orf41","accession":"Q9Y2V0","gene":"C15orf41","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3341185211460708,"antibodyCount":100,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.735389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":0.0,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(3008)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(3008)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3008)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3008)/publications"},"_namespace":null},{"id":3009,"version":2,"created":1554875617000,"modified":1554875620000,"deprecated":false,"name":"Adenylate kinase 4, mitochondrial","accession":"P27144","gene":"AK4","description":"Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.830285605635185,"antibodyCount":272,"monoclonalCount":87,"pubmedCount":null,"jensenScore":66.541162,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.74371605163566,"pubTatorScore":1.2752398571036863,"self":"https://pharos.nih.gov/idg/api/v1/targets(3009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(3009)/properties"},"_links":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(3009)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(3009)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3009)/publications"},"_namespace":null},{"id":3010,"version":2,"created":1554875621000,"modified":1554875623000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit rho-2","accession":"P28476","gene":"GABRR2","description":"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.7436544253841788,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":53.859901,"patentCount":1150,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.74284246592097,"pubTatorScore":0.8465882745165487,"self":"https://pharos.nih.gov/idg/api/v1/targets(3010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3010)/publications"},"_namespace":null},{"id":3011,"version":3,"created":1554875624000,"modified":1555034471000,"deprecated":false,"name":"Calcium-binding protein 39","accession":"Q9Y376","gene":"CAB39","description":"Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6173300245120075,"antibodyCount":103,"monoclonalCount":11,"pubmedCount":null,"jensenScore":37.916826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.38488751169849,"pubTatorScore":1.2230259322145924,"self":"https://pharos.nih.gov/idg/api/v1/targets(3011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(3011)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3011)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3011)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3011)/publications"},"_namespace":null},{"id":3012,"version":3,"created":1554875627000,"modified":1555034473000,"deprecated":false,"name":"Complex I intermediate-associated protein 30, mitochondrial","accession":"Q9Y375","gene":"NDUFAF1","description":"Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-1.105163096379376,"antibodyCount":103,"monoclonalCount":11,"pubmedCount":null,"jensenScore":12.472313,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.32565899597642,"pubTatorScore":1.1202112755429932,"self":"https://pharos.nih.gov/idg/api/v1/targets(3012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(3012)/properties"},"_links":{"count":1079,"href":"https://pharos.nih.gov/idg/api/v1/targets(3012)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3012)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3012)/publications"},"_namespace":null},{"id":3013,"version":2,"created":1554875632000,"modified":1554875634000,"deprecated":false,"name":"Sarcospan","accession":"Q14714","gene":"SSPN","description":"Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6422208030778664,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":48.732585,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.98296812826166,"pubTatorScore":1.4912980440144215,"self":"https://pharos.nih.gov/idg/api/v1/targets(3013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3013)/publications"},"_namespace":null},{"id":3014,"version":2,"created":1554875635000,"modified":1554875635000,"deprecated":false,"name":"Immunoglobulin lambda variable 5-39","accession":"A0A0G2JS06","gene":"IGLV5-39","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3014)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3014)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3014)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3014)/publications"},"_namespace":null},{"id":3015,"version":3,"created":1554875635000,"modified":1555034475000,"deprecated":false,"name":"Conserved oligomeric Golgi complex subunit 6","accession":"Q9Y2V7","gene":"COG6","description":"Required for normal Golgi function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6008318076436105,"antibodyCount":126,"monoclonalCount":92,"pubmedCount":null,"jensenScore":40.255343,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":37.48954788233229,"pubTatorScore":1.186531349187981,"self":"https://pharos.nih.gov/idg/api/v1/targets(3015)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(3015)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(3015)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3015)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3015)/publications"},"_namespace":null},{"id":3016,"version":2,"created":1554875639000,"modified":1554875661000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit beta-3","accession":"P28472","gene":"GABRB3","description":"Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.1320472221126816,"antibodyCount":202,"monoclonalCount":69,"pubmedCount":null,"jensenScore":135.992537,"patentCount":2715,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.54426957986513,"pubTatorScore":2.1425426436774773,"self":"https://pharos.nih.gov/idg/api/v1/targets(3016)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(3016)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(3016)/links"},"_synonyms":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3016)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3016)/publications"},"_namespace":null},{"id":3017,"version":3,"created":1554875663000,"modified":1555034477000,"deprecated":false,"name":"Melanopsin","accession":"Q9UHM6","gene":"OPN4","description":"Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-2.7724629275029704,"antibodyCount":65,"monoclonalCount":1,"pubmedCount":null,"jensenScore":589.637378,"patentCount":24698,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":23.4086948399497,"pubTatorScore":1.5886694392763165,"self":"https://pharos.nih.gov/idg/api/v1/targets(3017)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3017)/properties"},"_links":{"count":661,"href":"https://pharos.nih.gov/idg/api/v1/targets(3017)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3017)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3017)/publications"},"_namespace":null},{"id":3018,"version":2,"created":1554875665000,"modified":1554875667000,"deprecated":false,"name":"Glycolipid transfer protein domain-containing protein 2","accession":"A6NH11","gene":"GLTPD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.39312817929723,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3018)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(3018)/properties"},"_links":{"count":710,"href":"https://pharos.nih.gov/idg/api/v1/targets(3018)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3018)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3018)/publications"},"_namespace":null},{"id":3019,"version":2,"created":1554875667000,"modified":1554875670000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 27","accession":"Q96NW4","gene":"ANKRD27","description":"May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.125482466092201,"antibodyCount":65,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.582343,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.33936849456491,"pubTatorScore":0.7926418271089749,"self":"https://pharos.nih.gov/idg/api/v1/targets(3019)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(3019)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(3019)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3019)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3019)/publications"},"_namespace":null},{"id":3020,"version":2,"created":1554875671000,"modified":1554875671000,"deprecated":false,"name":"Rhox homeobox family member 2","accession":"Q9BQY4","gene":"RHOXF2","description":"Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.7256394425899283,"antibodyCount":128,"monoclonalCount":11,"pubmedCount":null,"jensenScore":6.504177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.32559234183476,"pubTatorScore":0.9606498811257519,"self":"https://pharos.nih.gov/idg/api/v1/targets(3020)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(3020)/properties"},"_links":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(3020)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3020)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3020)/publications"},"_namespace":null},{"id":3021,"version":3,"created":1554875672000,"modified":1555034478000,"deprecated":false,"name":"Tyrosine-protein kinase STYK1","accession":"Q6J9G0","gene":"STYK1","description":"Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.336645894985152,"antibodyCount":239,"monoclonalCount":97,"pubmedCount":null,"jensenScore":210.663948,"patentCount":5331,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.40003368018715,"pubTatorScore":2.1270134702454215,"self":"https://pharos.nih.gov/idg/api/v1/targets(3021)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(3021)/properties"},"_links":{"count":840,"href":"https://pharos.nih.gov/idg/api/v1/targets(3021)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3021)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3021)/publications"},"_namespace":null},{"id":3022,"version":2,"created":1554875675000,"modified":1554875677000,"deprecated":false,"name":"RNA-binding protein 12","accession":"Q9NTZ6","gene":"RBM12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8553172167771292,"antibodyCount":111,"monoclonalCount":7,"pubmedCount":null,"jensenScore":7.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.570179735934424,"pubTatorScore":2.1612182196910164,"self":"https://pharos.nih.gov/idg/api/v1/targets(3022)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(3022)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3022)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3022)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3022)/publications"},"_namespace":null},{"id":3023,"version":3,"created":1554875678000,"modified":1555034479000,"deprecated":false,"name":"UV excision repair protein RAD23 homolog B","accession":"P54727","gene":"RAD23B","description":"The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9941188304798478,"antibodyCount":313,"monoclonalCount":72,"pubmedCount":null,"jensenScore":96.76713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":48.0881105701836,"pubTatorScore":1.7977566535369864,"self":"https://pharos.nih.gov/idg/api/v1/targets(3023)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/synonyms"},"_publications":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3023)/publications"},"_namespace":null},{"id":3024,"version":2,"created":1554875683000,"modified":1554875685000,"deprecated":false,"name":"Dysbindin domain-containing protein 2","accession":"Q9BQY9","gene":"DBNDD2","description":"May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.22847932792314973,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.661027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.95528097339381,"pubTatorScore":0.1356623901490546,"self":"https://pharos.nih.gov/idg/api/v1/targets(3024)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(3024)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(3024)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3024)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3024)/publications"},"_namespace":null},{"id":3025,"version":3,"created":1554875686000,"modified":1555034481000,"deprecated":false,"name":"UV excision repair protein RAD23 homolog A","accession":"P54725","gene":"RAD23A","description":"Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.572819107856202,"antibodyCount":356,"monoclonalCount":68,"pubmedCount":null,"jensenScore":35.696191,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.48243414961172,"pubTatorScore":1.7446493574220558,"self":"https://pharos.nih.gov/idg/api/v1/targets(3025)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/properties"},"_links":{"count":1144,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3025)/publications"},"_namespace":null},{"id":3026,"version":2,"created":1554875689000,"modified":1554875690000,"deprecated":false,"name":"WAP four-disulfide core domain protein 6","accession":"Q9BQY6","gene":"WFDC6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.03476210770686023,"antibodyCount":2,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.743589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.128914059590625,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3026)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/properties"},"_links":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3026)/publications"},"_namespace":null},{"id":3027,"version":2,"created":1554875690000,"modified":1554875709000,"deprecated":false,"name":"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha","accession":"P16499","gene":"PDE6A","description":"This protein participates in processes of transmission and amplification of the visual signal.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.2922764854140782,"antibodyCount":111,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.270705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.043413971396944,"pubTatorScore":1.9701159226817389,"self":"https://pharos.nih.gov/idg/api/v1/targets(3027)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3027)/publications"},"_namespace":null},{"id":3028,"version":2,"created":1554875710000,"modified":1554875712000,"deprecated":false,"name":"Phylloquinone omega-hydroxylase CYP4F11","accession":"Q9HBI6","gene":"CYP4F11","description":"Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3-hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.712127311253229,"antibodyCount":96,"monoclonalCount":10,"pubmedCount":null,"jensenScore":6.597508,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.09550820314375,"pubTatorScore":0.8773057359519124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3028)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3028)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(3028)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3028)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3028)/publications"},"_namespace":null},{"id":3029,"version":3,"created":1554875713000,"modified":1555034483000,"deprecated":false,"name":"Uncharacterized protein C3orf14","accession":"Q9HBI5","gene":"C3orf14","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5740312677277188,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.269668,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":-0.5519804389939311,"self":"https://pharos.nih.gov/idg/api/v1/targets(3029)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(3029)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(3029)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3029)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3029)/publications"},"_namespace":null},{"id":3030,"version":3,"created":1554875715000,"modified":1555034484000,"deprecated":false,"name":"Gamma-parvin","accession":"Q9HBI0","gene":"PARVG","description":"Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.73756492962377,"antibodyCount":71,"monoclonalCount":28,"pubmedCount":null,"jensenScore":5.916592,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":24.66759495595187,"pubTatorScore":0.7116315361475423,"self":"https://pharos.nih.gov/idg/api/v1/targets(3030)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3030)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(3030)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3030)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3030)/publications"},"_namespace":null},{"id":3031,"version":3,"created":1554875718000,"modified":1555034485000,"deprecated":false,"name":"Beta-parvin","accession":"Q9HBI1","gene":"PARVB","description":"Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2671692703032027,"antibodyCount":137,"monoclonalCount":92,"pubmedCount":null,"jensenScore":17.423076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.10576716378907,"pubTatorScore":1.2696704291324543,"self":"https://pharos.nih.gov/idg/api/v1/targets(3031)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3031)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(3031)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(3031)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3031)/publications"},"_namespace":null},{"id":3032,"version":3,"created":1554875722000,"modified":1555034487000,"deprecated":false,"name":"Putative RNA-binding protein Luc7-like 2","accession":"Q9Y383","gene":"LUC7L2","description":"May bind to RNA via its Arg/Ser-rich domain.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.27406533927915966,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.576786,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":38,"knowledgeAvailability":40.31858551479144,"pubTatorScore":0.5300318410571215,"self":"https://pharos.nih.gov/idg/api/v1/targets(3032)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(3032)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(3032)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3032)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3032)/publications"},"_namespace":null},{"id":3033,"version":2,"created":1554875725000,"modified":1554875727000,"deprecated":false,"name":"Proton-associated sugar transporter A","accession":"Q9Y2W3","gene":"SLC45A1","description":"Proton-associated glucose transporter in the brain.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.533723511196485,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.400666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.821453313587348,"pubTatorScore":2.3732974026042575,"self":"https://pharos.nih.gov/idg/api/v1/targets(3033)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(3033)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(3033)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3033)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3033)/publications"},"_namespace":null},{"id":3034,"version":2,"created":1554875728000,"modified":1554875729000,"deprecated":false,"name":"Protein CC2D2B","accession":"Q6DHV5","gene":"CC2D2B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0413926851582251,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.058824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.62746696094518,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3034)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(3034)/properties"},"_links":{"count":714,"href":"https://pharos.nih.gov/idg/api/v1/targets(3034)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3034)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3034)/publications"},"_namespace":null},{"id":3035,"version":3,"created":1554875730000,"modified":1555034488000,"deprecated":false,"name":"WW domain-binding protein 11","accession":"Q9Y2W2","gene":"WBP11","description":"Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1086214038538775,"antibodyCount":74,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.778507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.606325946329775,"pubTatorScore":0.9182050684431264,"self":"https://pharos.nih.gov/idg/api/v1/targets(3035)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(3035)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(3035)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3035)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3035)/publications"},"_namespace":null},{"id":3036,"version":3,"created":1554875733000,"modified":1555034491000,"deprecated":false,"name":"Transcription factor Dp family member 3","accession":"Q5H9I0","gene":"TFDP3","description":"Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.365007122402264,"antibodyCount":132,"monoclonalCount":39,"pubmedCount":null,"jensenScore":219.224656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":17.027955234466326,"pubTatorScore":0.5835765478692101,"self":"https://pharos.nih.gov/idg/api/v1/targets(3036)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3036)/properties"},"_links":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3036)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3036)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3036)/publications"},"_namespace":null},{"id":3037,"version":2,"created":1554875734000,"modified":1554875734000,"deprecated":false,"name":"Putative uncharacterized protein DNAJC9-AS1","accession":"A6NH13","gene":"DNAJC9-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.70089996249266,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3037)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3037)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3037)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3037)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3037)/publications"},"_namespace":null},{"id":3038,"version":3,"created":1554875734000,"modified":1555034491000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 J1","accession":"Q9Y385","gene":"UBE2J1","description":"Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1202343206635041,"antibodyCount":250,"monoclonalCount":131,"pubmedCount":null,"jensenScore":12.822628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.93574376743661,"pubTatorScore":1.1193187518245094,"self":"https://pharos.nih.gov/idg/api/v1/targets(3038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(3038)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(3038)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3038)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3038)/publications"},"_namespace":null},{"id":3039,"version":2,"created":1554875737000,"modified":1554875739000,"deprecated":false,"name":"Nuclear envelope phosphatase-regulatory subunit 1","accession":"Q8N9A8","gene":"CNEP1R1","description":"Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.3222192947339193,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.605,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.894377745396717,"pubTatorScore":-0.4881166390211256,"self":"https://pharos.nih.gov/idg/api/v1/targets(3039)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(3039)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(3039)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3039)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3039)/publications"},"_namespace":null},{"id":3040,"version":2,"created":1554875740000,"modified":1554875742000,"deprecated":false,"name":"Adenosine deaminase-like protein","accession":"Q6DHV7","gene":"ADAL","description":"Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.372473668471236,"antibodyCount":68,"monoclonalCount":3,"pubmedCount":null,"jensenScore":22.254618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.555975849829597,"pubTatorScore":0.808436031785806,"self":"https://pharos.nih.gov/idg/api/v1/targets(3040)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3040)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(3040)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3040)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3040)/publications"},"_namespace":null},{"id":3041,"version":3,"created":1554875742000,"modified":1555034492000,"deprecated":false,"name":"DNA polymerase subunit gamma-2, mitochondrial","accession":"Q9UHN1","gene":"POLG2","description":"Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3478462345241033,"antibodyCount":105,"monoclonalCount":6,"pubmedCount":null,"jensenScore":20.298299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":36.556690476390166,"pubTatorScore":1.5234165768099086,"self":"https://pharos.nih.gov/idg/api/v1/targets(3041)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(3041)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(3041)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3041)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3041)/publications"},"_namespace":null},{"id":3042,"version":2,"created":1554875746000,"modified":1554875749000,"deprecated":false,"name":"Thyroid hormone receptor-associated protein 3","accession":"Q9Y2W1","gene":"THRAP3","description":"Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8776899965503315,"antibodyCount":136,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.808617,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.98559270297084,"pubTatorScore":1.00697508779262,"self":"https://pharos.nih.gov/idg/api/v1/targets(3042)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(3042)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(3042)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3042)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3042)/publications"},"_namespace":null},{"id":3043,"version":3,"created":1554875749000,"modified":1555034493000,"deprecated":false,"name":"Histone-lysine N-methyltransferase setd3","accession":"Q86TU7","gene":"SETD3","description":"Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). Acts as a transcriptional activator. Plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.5388668454167429,"antibodyCount":95,"monoclonalCount":6,"pubmedCount":null,"jensenScore":4.674898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.25053474736485,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(3043)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(3043)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(3043)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3043)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3043)/publications"},"_namespace":null},{"id":3044,"version":2,"created":1554875753000,"modified":1554875755000,"deprecated":false,"name":"N-acetylglucosamine-6-phosphate deacetylase","accession":"Q9Y303","gene":"AMDHD2","description":"Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.1083394632076522,"antibodyCount":87,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.956816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.41806000128235,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(3044)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(3044)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3044)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3044)/publications"},"_namespace":null},{"id":3045,"version":2,"created":1554875756000,"modified":1554875758000,"deprecated":false,"name":"Zinc finger protein 557","accession":"Q8N988","gene":"ZNF557","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":83,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.9479139209172,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3045)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3045)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(3045)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3045)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3045)/publications"},"_namespace":null},{"id":3046,"version":2,"created":1554875759000,"modified":1554875759000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC00523","accession":"Q86TU6","gene":"LINC00523","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.426814114948565,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3046)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3046)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3046)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3046)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3046)/publications"},"_namespace":null},{"id":3047,"version":2,"created":1554875759000,"modified":1554875761000,"deprecated":false,"name":"Acyl-coenzyme A thioesterase 9, mitochondrial","accession":"Q9Y305","gene":"ACOT9","description":"Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.1309290987694142,"antibodyCount":171,"monoclonalCount":34,"pubmedCount":null,"jensenScore":1.45,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.311465671982,"pubTatorScore":0.42596862369864713,"self":"https://pharos.nih.gov/idg/api/v1/targets(3047)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3047)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(3047)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3047)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3047)/publications"},"_namespace":null},{"id":3048,"version":2,"created":1554875762000,"modified":1554875764000,"deprecated":false,"name":"Zinc finger SWIM domain-containing protein 1","accession":"Q9BR11","gene":"ZSWIM1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":66,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.65622462000195,"pubTatorScore":0.09691001300805642,"self":"https://pharos.nih.gov/idg/api/v1/targets(3048)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(3048)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(3048)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3048)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3048)/publications"},"_namespace":null},{"id":3049,"version":3,"created":1554875764000,"modified":1555034495000,"deprecated":false,"name":"N-terminal EF-hand calcium-binding protein 1","accession":"Q8N987","gene":"NECAB1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3187587626244128,"antibodyCount":126,"monoclonalCount":31,"pubmedCount":null,"jensenScore":3.59567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":22.873409514619567,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(3049)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3049)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(3049)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3049)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3049)/publications"},"_namespace":null},{"id":3050,"version":3,"created":1554875768000,"modified":1555034496000,"deprecated":false,"name":"Mitochondrial genome maintenance exonuclease 1","accession":"Q9BQP7","gene":"MGME1","description":"Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0108178720915009,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.967096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":30.08593901786524,"pubTatorScore":0.8447061917114825,"self":"https://pharos.nih.gov/idg/api/v1/targets(3050)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(3050)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(3050)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3050)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3050)/publications"},"_namespace":null},{"id":3051,"version":2,"created":1554875771000,"modified":1554875773000,"deprecated":false,"name":"Epidermal growth factor-like protein 7","accession":"Q9UHF1","gene":"EGFL7","description":"Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7869026628667761,"antibodyCount":217,"monoclonalCount":53,"pubmedCount":null,"jensenScore":72.840156,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.61846804901901,"pubTatorScore":1.773969446189909,"self":"https://pharos.nih.gov/idg/api/v1/targets(3051)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(3051)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(3051)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3051)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3051)/publications"},"_namespace":null},{"id":3052,"version":3,"created":1554875774000,"modified":1555034497000,"deprecated":false,"name":"Tachykinin-3","accession":"Q9UHF0","gene":"TAC3","description":"Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.6858419418981336,"antibodyCount":196,"monoclonalCount":15,"pubmedCount":null,"jensenScore":422.555333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.451099371755234,"pubTatorScore":2.3791265878361787,"self":"https://pharos.nih.gov/idg/api/v1/targets(3052)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(3052)/properties"},"_links":{"count":824,"href":"https://pharos.nih.gov/idg/api/v1/targets(3052)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3052)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3052)/publications"},"_namespace":null},{"id":3053,"version":2,"created":1554875780000,"modified":1554875780000,"deprecated":false,"name":"Serine incorporator 4","accession":"A6NH21","gene":"SERINC4","description":"Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.115421344135072,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3053)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3053)/properties"},"_links":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3053)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3053)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3053)/publications"},"_namespace":null},{"id":3054,"version":2,"created":1554875780000,"modified":1554875781000,"deprecated":false,"name":"Oocyte-expressed protein homolog","accession":"A6NGQ2","gene":"OOEP","description":"As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6030927894034048,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.19652,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.318012400359288,"pubTatorScore":-0.16840470468072857,"self":"https://pharos.nih.gov/idg/api/v1/targets(3054)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(3054)/properties"},"_links":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(3054)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3054)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3054)/publications"},"_namespace":null},{"id":3055,"version":3,"created":1554875782000,"modified":1555034499000,"deprecated":false,"name":"Interleukin-17B","accession":"Q9UHF5","gene":"IL17B","description":"Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.180850135124881,"antibodyCount":290,"monoclonalCount":102,"pubmedCount":null,"jensenScore":14.902544,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":18.220816111370844,"pubTatorScore":1.523698990888741,"self":"https://pharos.nih.gov/idg/api/v1/targets(3055)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(3055)/properties"},"_links":{"count":671,"href":"https://pharos.nih.gov/idg/api/v1/targets(3055)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3055)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3055)/publications"},"_namespace":null},{"id":3056,"version":3,"created":1554875784000,"modified":1555034502000,"deprecated":false,"name":"Interleukin-20 receptor subunit alpha","accession":"Q9UHF4","gene":"IL20RA","description":"The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4479658054720277,"antibodyCount":230,"monoclonalCount":71,"pubmedCount":null,"jensenScore":22.546368,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":29.93147217697714,"pubTatorScore":1.2334540114942485,"self":"https://pharos.nih.gov/idg/api/v1/targets(3056)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(3056)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(3056)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3056)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3056)/publications"},"_namespace":null},{"id":3057,"version":3,"created":1554875787000,"modified":1555034503000,"deprecated":false,"name":"Putative N-acetyltransferase 8B","accession":"Q9UHF3","gene":"NAT8B","description":"May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":16.330554524053117,"pubTatorScore":1.232814608489586,"self":"https://pharos.nih.gov/idg/api/v1/targets(3057)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3057)/properties"},"_links":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3057)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3057)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3057)/publications"},"_namespace":null},{"id":3058,"version":3,"created":1554875787000,"modified":1555034504000,"deprecated":false,"name":"Spermatogenesis-associated protein 25","accession":"Q9BR10","gene":"SPATA25","description":"May play a role in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.0,"antibodyCount":46,"monoclonalCount":15,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":16.77010926968168,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(3058)/properties"},"_links":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(3058)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3058)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3058)/publications"},"_namespace":null},{"id":3059,"version":2,"created":1554875790000,"modified":1554875793000,"deprecated":false,"name":"Zinc finger transcription factor Trps1","accession":"Q9UHF7","gene":"TRPS1","description":"Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9875622569044424,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":106.988225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.046487329313486,"pubTatorScore":2.012028215894899,"self":"https://pharos.nih.gov/idg/api/v1/targets(3059)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(3059)/properties"},"_links":{"count":1120,"href":"https://pharos.nih.gov/idg/api/v1/targets(3059)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3059)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3059)/publications"},"_namespace":null},{"id":3060,"version":2,"created":1554875794000,"modified":1554875795000,"deprecated":false,"name":"Epiphycan","accession":"Q99645","gene":"EPYC","description":"May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6204334400271343,"antibodyCount":82,"monoclonalCount":10,"pubmedCount":null,"jensenScore":40.65934,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.3979174443839,"pubTatorScore":0.9941704269950534,"self":"https://pharos.nih.gov/idg/api/v1/targets(3060)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3060)/properties"},"_links":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(3060)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3060)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3060)/publications"},"_namespace":null},{"id":3061,"version":2,"created":1554875796000,"modified":1554875800000,"deprecated":false,"name":"Histone-lysine N-methyltransferase SETD7","accession":"Q8WTS6","gene":"SETD7","description":"Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.1364439922849328,"antibodyCount":343,"monoclonalCount":111,"pubmedCount":null,"jensenScore":139.845263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.27418241545667,"pubTatorScore":1.8748586090551758,"self":"https://pharos.nih.gov/idg/api/v1/targets(3061)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3061)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(3061)/links"},"_synonyms":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(3061)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3061)/publications"},"_namespace":null},{"id":3062,"version":2,"created":1554875801000,"modified":1554875803000,"deprecated":false,"name":"Uncharacterized protein C2orf15","accession":"Q8WU43","gene":"C2orf15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.3222192947339193,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.052632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3062)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(3062)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(3062)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3062)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3062)/publications"},"_namespace":null},{"id":3063,"version":3,"created":1554875803000,"modified":1555034505000,"deprecated":false,"name":"TOX high mobility group box family member 2","accession":"Q96NM4","gene":"TOX2","description":"Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.2919129805089424,"antibodyCount":104,"monoclonalCount":3,"pubmedCount":null,"jensenScore":19.508578,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":28.487865263479804,"pubTatorScore":0.5740312677277188,"self":"https://pharos.nih.gov/idg/api/v1/targets(3063)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3063)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(3063)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3063)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3063)/publications"},"_namespace":null},{"id":3064,"version":2,"created":1554875806000,"modified":1554875810000,"deprecated":false,"name":"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial","accession":"Q99643","gene":"SDHC","description":"Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7379074104731584,"antibodyCount":129,"monoclonalCount":39,"pubmedCount":null,"jensenScore":419.899108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.41400799996638,"pubTatorScore":2.507746608612838,"self":"https://pharos.nih.gov/idg/api/v1/targets(3064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(3064)/properties"},"_links":{"count":1257,"href":"https://pharos.nih.gov/idg/api/v1/targets(3064)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3064)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3064)/publications"},"_namespace":null},{"id":3065,"version":3,"created":1554875811000,"modified":1555034506000,"deprecated":false,"name":"1-acylglycerol-3-phosphate O-acyltransferase ABHD5","accession":"Q8WTS1","gene":"ABHD5","description":"Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9552423631027747,"antibodyCount":243,"monoclonalCount":55,"pubmedCount":null,"jensenScore":94.770234,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":37.037972373918,"pubTatorScore":1.7802350981032233,"self":"https://pharos.nih.gov/idg/api/v1/targets(3065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(3065)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(3065)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3065)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3065)/publications"},"_namespace":null},{"id":3066,"version":2,"created":1554875815000,"modified":1554875817000,"deprecated":false,"name":"Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase","accession":"Q99640","gene":"PKMYT1","description":"Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.2723666074929616,"antibodyCount":364,"monoclonalCount":34,"pubmedCount":null,"jensenScore":19.156716,"patentCount":14407,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.16306009026076,"pubTatorScore":1.1314097742850346,"self":"https://pharos.nih.gov/idg/api/v1/targets(3066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(3066)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(3066)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3066)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3066)/publications"},"_namespace":null},{"id":3067,"version":4,"created":1554875818000,"modified":1555034508000,"deprecated":false,"name":"Tyrosine-protein phosphatase non-receptor type 2","accession":"P17706","gene":"PTPN2","description":"Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.5345145362938153,"antibodyCount":192,"monoclonalCount":11,"pubmedCount":null,"jensenScore":297.249722,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.39411257657017,"pubTatorScore":2.2284694784074106,"self":"https://pharos.nih.gov/idg/api/v1/targets(3067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":604,"href":"https://pharos.nih.gov/idg/api/v1/targets(3067)/properties"},"_links":{"count":1379,"href":"https://pharos.nih.gov/idg/api/v1/targets(3067)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3067)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(3067)/publications"},"_namespace":null},{"id":3068,"version":2,"created":1554875880000,"modified":1554875883000,"deprecated":false,"name":"LIM domain-binding protein 1","accession":"Q86U70","gene":"LDB1","description":"Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2262347584656546,"antibodyCount":206,"monoclonalCount":56,"pubmedCount":null,"jensenScore":164.362835,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.940053814533364,"pubTatorScore":1.7756453648983241,"self":"https://pharos.nih.gov/idg/api/v1/targets(3068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(3068)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(3068)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3068)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3068)/publications"},"_namespace":null},{"id":3069,"version":2,"created":1554875884000,"modified":1554875891000,"deprecated":false,"name":"S-adenosylmethionine decarboxylase proenzyme","accession":"P17707","gene":"AMD1","description":"Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.2182589824272165,"antibodyCount":141,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1586.792759,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.77101250233016,"pubTatorScore":2.1845089093075662,"self":"https://pharos.nih.gov/idg/api/v1/targets(3069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(3069)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(3069)/links"},"_synonyms":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(3069)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3069)/publications"},"_namespace":null},{"id":3070,"version":2,"created":1554875892000,"modified":1554875894000,"deprecated":false,"name":"Neuralized-like protein 2","accession":"Q9BR09","gene":"NEURL2","description":"Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4128470521240152,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.164286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.964794481412344,"pubTatorScore":0.3891660843645325,"self":"https://pharos.nih.gov/idg/api/v1/targets(3070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(3070)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(3070)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3070)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3070)/publications"},"_namespace":null},{"id":3071,"version":3,"created":1554875895000,"modified":1555034510000,"deprecated":false,"name":"Patatin-like phospholipase domain-containing protein 1","accession":"Q8N8W4","gene":"PNPLA1","description":"Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3367376413612344,"antibodyCount":102,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.450376,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":20.285037779430603,"pubTatorScore":0.8191781845812264,"self":"https://pharos.nih.gov/idg/api/v1/targets(3071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3071)/properties"},"_links":{"count":738,"href":"https://pharos.nih.gov/idg/api/v1/targets(3071)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3071)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3071)/publications"},"_namespace":null},{"id":3072,"version":3,"created":1554875897000,"modified":1555034511000,"deprecated":false,"name":"Uncharacterized protein C7orf33","accession":"Q8WU49","gene":"C7orf33","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3072)/properties"},"_links":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3072)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3072)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3072)/publications"},"_namespace":null},{"id":3073,"version":3,"created":1554875897000,"modified":1555034511000,"deprecated":false,"name":"39S ribosomal protein L43, mitochondrial","accession":"Q8N983","gene":"MRPL43","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.34756232140524834,"antibodyCount":33,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.643398,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":30.81537842001633,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(3073)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(3073)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3073)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3073)/publications"},"_namespace":null},{"id":3074,"version":3,"created":1554875900000,"modified":1555034513000,"deprecated":false,"name":"Transmembrane protein 95","accession":"Q3KNT9","gene":"TMEM95","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3979400086720376,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.844538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":10.689428153108238,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3074)/properties"},"_links":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(3074)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3074)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3074)/publications"},"_namespace":null},{"id":3075,"version":3,"created":1554875902000,"modified":1555034513000,"deprecated":false,"name":"Nitric oxide synthase-interacting protein","accession":"Q9Y314","gene":"NOSIP","description":"E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0035755019484616,"antibodyCount":124,"monoclonalCount":3,"pubmedCount":null,"jensenScore":10.82633,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.23214836530291,"pubTatorScore":0.5371191283569465,"self":"https://pharos.nih.gov/idg/api/v1/targets(3075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(3075)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(3075)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3075)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3075)/publications"},"_namespace":null},{"id":3076,"version":3,"created":1554875905000,"modified":1555034514000,"deprecated":false,"name":"Long-chain fatty acid transport protein 6","accession":"Q9Y2P4","gene":"SLC27A6","description":"Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.7280729364336815,"antibodyCount":56,"monoclonalCount":1,"pubmedCount":null,"jensenScore":51.726526,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":25.304848402377058,"pubTatorScore":0.8335677465128226,"self":"https://pharos.nih.gov/idg/api/v1/targets(3076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(3076)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(3076)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3076)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3076)/publications"},"_namespace":null},{"id":3077,"version":2,"created":1554875907000,"modified":1554875909000,"deprecated":false,"name":"Transmembrane protein 105","accession":"Q8N8V8","gene":"TMEM105","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.453585640401368,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3077)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(3077)/properties"},"_links":{"count":636,"href":"https://pharos.nih.gov/idg/api/v1/targets(3077)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3077)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3077)/publications"},"_namespace":null},{"id":3078,"version":3,"created":1554875909000,"modified":1555034515000,"deprecated":false,"name":"Sulfotransferase 4A1","accession":"Q9BR01","gene":"SULT4A1","description":"Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8582480502468663,"antibodyCount":129,"monoclonalCount":16,"pubmedCount":null,"jensenScore":71.25349,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.11958372615034,"pubTatorScore":1.481210713537472,"self":"https://pharos.nih.gov/idg/api/v1/targets(3078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(3078)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(3078)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3078)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3078)/publications"},"_namespace":null},{"id":3079,"version":3,"created":1554875912000,"modified":1555034517000,"deprecated":false,"name":"Protein MEMO1","accession":"Q9Y316","gene":"MEMO1","description":"May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.041341528281338,"antibodyCount":87,"monoclonalCount":33,"pubmedCount":null,"jensenScore":109.368807,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":24.158971932278,"pubTatorScore":1.1940839134882326,"self":"https://pharos.nih.gov/idg/api/v1/targets(3079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(3079)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(3079)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3079)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3079)/publications"},"_namespace":null},{"id":3080,"version":2,"created":1554875915000,"modified":1554875915000,"deprecated":false,"name":"Putative NOL1/NOP2/Sun domain family member 5B","accession":"Q3KNT7","gene":"NSUN5P1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.216245909784584,"pubTatorScore":-0.5362428425553659,"self":"https://pharos.nih.gov/idg/api/v1/targets(3080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3080)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3080)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3080)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3080)/publications"},"_namespace":null},{"id":3081,"version":2,"created":1554875915000,"modified":1554875917000,"deprecated":false,"name":"Deoxyribose-phosphate aldolase","accession":"Q9Y315","gene":"DERA","description":"Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.213737789395367,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":154.971931,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.81819547618431,"pubTatorScore":1.602531791349976,"self":"https://pharos.nih.gov/idg/api/v1/targets(3081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(3081)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(3081)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3081)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3081)/publications"},"_namespace":null},{"id":3082,"version":2,"created":1554875918000,"modified":1554875920000,"deprecated":false,"name":"Bile acyl-CoA synthetase","accession":"Q9Y2P5","gene":"SLC27A5","description":"Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.3217594033148243,"antibodyCount":181,"monoclonalCount":100,"pubmedCount":null,"jensenScore":196.762729,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.5465625477479,"pubTatorScore":2.2700417469320677,"self":"https://pharos.nih.gov/idg/api/v1/targets(3082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3082)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(3082)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3082)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3082)/publications"},"_namespace":null},{"id":3083,"version":2,"created":1554875921000,"modified":1554875921000,"deprecated":false,"name":"Putative uncharacterized protein FLJ38264","accession":"Q8N976","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3083)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3083)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3083)/links"},"_synonyms":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3083)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3083)/publications"},"_namespace":null},{"id":3084,"version":2,"created":1554875921000,"modified":1554875922000,"deprecated":false,"name":"Zinc finger protein 835","accession":"Q9Y2P0","gene":"ZNF835","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0,"antibodyCount":96,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.144358895694673,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3084)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(3084)/properties"},"_links":{"count":798,"href":"https://pharos.nih.gov/idg/api/v1/targets(3084)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3084)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3084)/publications"},"_namespace":null},{"id":3085,"version":2,"created":1554875923000,"modified":1554875925000,"deprecated":false,"name":"Prenylcysteine oxidase 1","accession":"Q9UHG3","gene":"PCYOX1","description":"Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6125606953872461,"antibodyCount":50,"monoclonalCount":10,"pubmedCount":null,"jensenScore":4.779155,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.09042223361649,"pubTatorScore":0.9530344572503567,"self":"https://pharos.nih.gov/idg/api/v1/targets(3085)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(3085)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(3085)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3085)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3085)/publications"},"_namespace":null},{"id":3086,"version":2,"created":1554875926000,"modified":1554875928000,"deprecated":false,"name":"ProSAAS","accession":"Q9UHG2","gene":"PCSK1N","description":"May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.288330249027943,"antibodyCount":73,"monoclonalCount":10,"pubmedCount":null,"jensenScore":187.984024,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.17713578678852,"pubTatorScore":1.3790247766881523,"self":"https://pharos.nih.gov/idg/api/v1/targets(3086)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3086)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(3086)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3086)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3086)/publications"},"_namespace":null},{"id":3087,"version":3,"created":1554875929000,"modified":1555034518000,"deprecated":false,"name":"Protein AAR2 homolog","accession":"Q9Y312","gene":"AAR2","description":"Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0881361049865947,"antibodyCount":56,"monoclonalCount":3,"pubmedCount":null,"jensenScore":13.572113,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":28.44747287075838,"pubTatorScore":0.4586378490256493,"self":"https://pharos.nih.gov/idg/api/v1/targets(3087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3087)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(3087)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3087)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3087)/publications"},"_namespace":null},{"id":3088,"version":3,"created":1554875931000,"modified":1555034519000,"deprecated":false,"name":"Glyceraldehyde-3-phosphate dehydrogenase","accession":"P04406","gene":"GAPDH","description":"Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.68189490795996,"antibodyCount":1886,"monoclonalCount":770,"pubmedCount":null,"jensenScore":4548.436334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":56.26545277784498,"pubTatorScore":3.370292861641085,"self":"https://pharos.nih.gov/idg/api/v1/targets(3088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(3088)/properties"},"_links":{"count":1377,"href":"https://pharos.nih.gov/idg/api/v1/targets(3088)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3088)/synonyms"},"_publications":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(3088)/publications"},"_namespace":null},{"id":3089,"version":2,"created":1554875941000,"modified":1554875943000,"deprecated":false,"name":"Doublecortin domain-containing protein 2","accession":"Q9UHG0","gene":"DCDC2","description":"Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7133138685191167,"antibodyCount":209,"monoclonalCount":3,"pubmedCount":null,"jensenScore":52.430138,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.77143581886965,"pubTatorScore":2.0924016508715413,"self":"https://pharos.nih.gov/idg/api/v1/targets(3089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(3089)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(3089)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3089)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3089)/publications"},"_namespace":null},{"id":3090,"version":3,"created":1554875944000,"modified":1555034522000,"deprecated":false,"name":"RNA 3'-terminal phosphate cyclase-like protein","accession":"Q9Y2P8","gene":"RCL1","description":"Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8651222731560224,"antibodyCount":113,"monoclonalCount":2,"pubmedCount":null,"jensenScore":69.817269,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":39.20407891809242,"pubTatorScore":0.7146091107142875,"self":"https://pharos.nih.gov/idg/api/v1/targets(3090)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(3090)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(3090)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3090)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3090)/publications"},"_namespace":null},{"id":3091,"version":2,"created":1554875947000,"modified":1554875949000,"deprecated":false,"name":"Zinc finger protein 256","accession":"Q9Y2P7","gene":"ZNF256","description":"Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.33953699187405434,"antibodyCount":110,"monoclonalCount":14,"pubmedCount":null,"jensenScore":0.636647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.23912285826962,"pubTatorScore":-0.022276394711152253,"self":"https://pharos.nih.gov/idg/api/v1/targets(3091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3091)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(3091)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3091)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3091)/publications"},"_namespace":null},{"id":3092,"version":3,"created":1554875950000,"modified":1555034524000,"deprecated":false,"name":"Glycoprotein integral membrane protein 1","accession":"Q9NU53","gene":"GINM1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":40,"knowledgeAvailability":24.22239692220688,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3092)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(3092)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(3092)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3092)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3092)/publications"},"_namespace":null},{"id":3093,"version":2,"created":1554875952000,"modified":1554875954000,"deprecated":false,"name":"Transmembrane protein 74","accession":"Q96NL1","gene":"TMEM74","description":"Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7249581759732318,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.538492,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.535670496594186,"pubTatorScore":0.3832168117540143,"self":"https://pharos.nih.gov/idg/api/v1/targets(3093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(3093)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(3093)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3093)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3093)/publications"},"_namespace":null},{"id":3094,"version":3,"created":1554875955000,"modified":1555034526000,"deprecated":false,"name":"Glycerophosphodiester phosphodiesterase domain-containing protein 5","accession":"Q8WTR4","gene":"GDPD5","description":"Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1991149399670133,"antibodyCount":110,"monoclonalCount":2,"pubmedCount":null,"jensenScore":17.642758,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":32.87799728216237,"pubTatorScore":1.0980665440064554,"self":"https://pharos.nih.gov/idg/api/v1/targets(3094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(3094)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(3094)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3094)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3094)/publications"},"_namespace":null},{"id":3095,"version":2,"created":1554875958000,"modified":1554875960000,"deprecated":false,"name":"RUN domain-containing protein 3B","accession":"Q96NL0","gene":"RUNDC3B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5966407168348093,"antibodyCount":40,"monoclonalCount":1,"pubmedCount":null,"jensenScore":3.474047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.602886954040535,"pubTatorScore":0.8619477198230406,"self":"https://pharos.nih.gov/idg/api/v1/targets(3095)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(3095)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(3095)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3095)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3095)/publications"},"_namespace":null},{"id":3096,"version":2,"created":1554875960000,"modified":1554875962000,"deprecated":false,"name":"Zinc finger protein 599","accession":"Q96NL3","gene":"ZNF599","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0413926851582251,"antibodyCount":82,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.043478,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.543973419068287,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(3096)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3096)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(3096)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3096)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3096)/publications"},"_namespace":null},{"id":3097,"version":3,"created":1554875963000,"modified":1555034527000,"deprecated":false,"name":"Dual specificity protein phosphatase 19","accession":"Q8WTR2","gene":"DUSP19","description":"Has a dual specificity toward Ser/Thr and Tyr-containing proteins.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5513919097592981,"antibodyCount":122,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.502431,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":27.742993034806624,"pubTatorScore":0.6643285500378061,"self":"https://pharos.nih.gov/idg/api/v1/targets(3097)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(3097)/properties"},"_links":{"count":861,"href":"https://pharos.nih.gov/idg/api/v1/targets(3097)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3097)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3097)/publications"},"_namespace":null},{"id":3098,"version":2,"created":1554875965000,"modified":1554875968000,"deprecated":false,"name":"Pre-mRNA-splicing factor 18","accession":"Q99633","gene":"PRPF18","description":"Participates in the second step of pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3618327394895153,"antibodyCount":84,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.780801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.02898579018873,"pubTatorScore":0.9808146757815629,"self":"https://pharos.nih.gov/idg/api/v1/targets(3098)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(3098)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(3098)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3098)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3098)/publications"},"_namespace":null},{"id":3099,"version":2,"created":1554875968000,"modified":1554875969000,"deprecated":false,"name":"Golgin subfamily A member 6-like protein 6","accession":"A8MZA4","gene":"GOLGA6L6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.519491190963829,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3099)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(3099)/properties"},"_links":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3099)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3099)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3099)/publications"},"_namespace":null},{"id":3100,"version":2,"created":1554875969000,"modified":1554875971000,"deprecated":false,"name":"Protein C8orf37","accession":"Q96NL8","gene":"C8orf37","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.100970589844994,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":123.368687,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.1338662940748816,"self":"https://pharos.nih.gov/idg/api/v1/targets(3100)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(3100)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(3100)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3100)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3100)/publications"},"_namespace":null},{"id":3101,"version":2,"created":1554875971000,"modified":1554875973000,"deprecated":false,"name":"Netrin-5","accession":"Q8WTR8","gene":"NTN5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.09091964849853494,"antibodyCount":32,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.546568,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.979573499065625,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(3101)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3101)/properties"},"_links":{"count":691,"href":"https://pharos.nih.gov/idg/api/v1/targets(3101)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3101)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3101)/publications"},"_namespace":null},{"id":3102,"version":3,"created":1554875973000,"modified":1555034528000,"deprecated":false,"name":"Cell cycle checkpoint control protein RAD9A","accession":"Q99638","gene":"RAD9A","description":"Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1533011265149136,"antibodyCount":919,"monoclonalCount":92,"pubmedCount":null,"jensenScore":140.997233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":45.3647552827502,"pubTatorScore":2.0284395780689177,"self":"https://pharos.nih.gov/idg/api/v1/targets(3102)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":516,"href":"https://pharos.nih.gov/idg/api/v1/targets(3102)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3102)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3102)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3102)/publications"},"_namespace":null},{"id":3103,"version":2,"created":1554875978000,"modified":1554875980000,"deprecated":false,"name":"Maestro heat-like repeat-containing protein family member 6","accession":"A6NGR9","gene":"MROH6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.300730257140252,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3103)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3103)/properties"},"_links":{"count":764,"href":"https://pharos.nih.gov/idg/api/v1/targets(3103)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3103)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3103)/publications"},"_namespace":null},{"id":3104,"version":2,"created":1554875980000,"modified":1554875982000,"deprecated":false,"name":"Ankyrin repeat and SAM domain-containing protein 4B","accession":"Q8N8V4","gene":"ANKS4B","description":"As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.12493873660829995,"antibodyCount":59,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.576471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.956575620132256,"pubTatorScore":2.048154985157336,"self":"https://pharos.nih.gov/idg/api/v1/targets(3104)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3104)/properties"},"_links":{"count":668,"href":"https://pharos.nih.gov/idg/api/v1/targets(3104)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3104)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3104)/publications"},"_namespace":null},{"id":3105,"version":2,"created":1554875982000,"modified":1554875984000,"deprecated":false,"name":"Marginal zone B- and B1-cell-specific protein","accession":"Q8WU39","gene":"MZB1","description":"Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1110570327609413,"antibodyCount":71,"monoclonalCount":4,"pubmedCount":null,"jensenScore":17.110992,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.386276855821194,"pubTatorScore":1.2104076975772207,"self":"https://pharos.nih.gov/idg/api/v1/targets(3105)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(3105)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(3105)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3105)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3105)/publications"},"_namespace":null},{"id":3106,"version":2,"created":1554875985000,"modified":1554875987000,"deprecated":false,"name":"Zinc finger protein 709","accession":"Q8N972","gene":"ZNF709","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.032258,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.835738078842034,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3106)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(3106)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(3106)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3106)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3106)/publications"},"_namespace":null},{"id":3107,"version":2,"created":1554875987000,"modified":1554875989000,"deprecated":false,"name":"Guanylate-binding protein 7","accession":"Q8N8V2","gene":"GBP7","description":"Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4548448637000133,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.618686,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.440179683545804,"pubTatorScore":0.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(3107)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(3107)/properties"},"_links":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(3107)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3107)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3107)/publications"},"_namespace":null},{"id":3108,"version":2,"created":1554875989000,"modified":1554875991000,"deprecated":false,"name":"Sodium channel and clathrin linker 1","accession":"Q96NL6","gene":"SCLT1","description":"Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.508198280637978,"antibodyCount":97,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.611779,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.499472723459753,"pubTatorScore":0.5310277829508891,"self":"https://pharos.nih.gov/idg/api/v1/targets(3108)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3108)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(3108)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3108)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3108)/publications"},"_namespace":null},{"id":3109,"version":2,"created":1554875992000,"modified":1554875994000,"deprecated":false,"name":"Zinc finger protein 473","accession":"Q8WTR7","gene":"ZNF473","description":"Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1162966702230128,"antibodyCount":101,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.581691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.02921872899518,"pubTatorScore":0.5986862416937077,"self":"https://pharos.nih.gov/idg/api/v1/targets(3109)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(3109)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(3109)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3109)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3109)/publications"},"_namespace":null},{"id":3110,"version":2,"created":1554875995000,"modified":1554875996000,"deprecated":false,"name":"Palmitoyltransferase ZDHHC22","accession":"Q8N966","gene":"ZDHHC22","description":"Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.10187343388197125,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.72589325811356,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3110)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(3110)/properties"},"_links":{"count":604,"href":"https://pharos.nih.gov/idg/api/v1/targets(3110)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3110)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3110)/publications"},"_namespace":null},{"id":3111,"version":3,"created":1554875997000,"modified":1555034530000,"deprecated":false,"name":"Ragulator complex protein LAMTOR2","accession":"Q9Y2Q5","gene":"LAMTOR2","description":"As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9631896808908474,"antibodyCount":81,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.784527,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.65492299041795,"pubTatorScore":0.8629922540626748,"self":"https://pharos.nih.gov/idg/api/v1/targets(3111)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3111)/publications"},"_namespace":null},{"id":3112,"version":3,"created":1554876000000,"modified":1555034531000,"deprecated":false,"name":"Leucine-rich repeat and transmembrane domain-containing protein 2","accession":"Q8N967","gene":"LRTM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.33881855619146894,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.424242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":20.376803049321953,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3112)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/properties"},"_links":{"count":665,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3112)/publications"},"_namespace":null},{"id":3113,"version":2,"created":1554876003000,"modified":1554876004000,"deprecated":false,"name":"Protein FAM83C","accession":"Q9BQN1","gene":"FAM83C","description":"May play a role in MAPK signaling.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.626682521751418,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(3113)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/properties"},"_links":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3113)/publications"},"_namespace":null},{"id":3114,"version":2,"created":1554876005000,"modified":1554876007000,"deprecated":false,"name":"N6-adenosine-methyltransferase catalytic subunit","accession":"Q86U44","gene":"METTL3","description":"The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and haematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.761740065764843,"antibodyCount":94,"monoclonalCount":4,"pubmedCount":null,"jensenScore":60.489745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.83411852373786,"pubTatorScore":1.3724736412466039,"self":"https://pharos.nih.gov/idg/api/v1/targets(3114)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/properties"},"_links":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3114)/publications"},"_namespace":null},{"id":3115,"version":3,"created":1554876008000,"modified":1555034534000,"deprecated":false,"name":"rRNA-processing protein FCF1 homolog","accession":"Q9Y324","gene":"FCF1","description":"Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.006221318956311,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":96.255789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":32.3200598024354,"pubTatorScore":1.177330298176396,"self":"https://pharos.nih.gov/idg/api/v1/targets(3115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3115)/publications"},"_namespace":null},{"id":3116,"version":2,"created":1554876011000,"modified":1554876014000,"deprecated":false,"name":"Polyadenylate-binding protein 2","accession":"Q86U42","gene":"PABPN1","description":"Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters (PubMed:27871484).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4875731089631583,"antibodyCount":120,"monoclonalCount":13,"pubmedCount":null,"jensenScore":316.411224,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.61439117889239,"pubTatorScore":2.2081607884563956,"self":"https://pharos.nih.gov/idg/api/v1/targets(3116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/properties"},"_links":{"count":1202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/synonyms"},"_publications":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3116)/publications"},"_namespace":null},{"id":3117,"version":2,"created":1554876015000,"modified":1554876017000,"deprecated":false,"name":"Zinc finger protein 257","accession":"Q9Y2Q1","gene":"ZNF257","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.130435,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.502930192622976,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(3117)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3117)/publications"},"_namespace":null},{"id":3118,"version":3,"created":1554876018000,"modified":1555034536000,"deprecated":false,"name":"Thioredoxin-related transmembrane protein 2","accession":"Q9Y320","gene":"TMX2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9287493192879259,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.356068,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.77290262603219,"pubTatorScore":0.7556328786278821,"self":"https://pharos.nih.gov/idg/api/v1/targets(3118)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3118)/publications"},"_namespace":null},{"id":3119,"version":2,"created":1554876020000,"modified":1554876024000,"deprecated":false,"name":"Phospholipid-transporting ATPase IA","accession":"Q9Y2Q0","gene":"ATP8A1","description":"Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.5615750610742145,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":35.475216,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.48462851421292,"pubTatorScore":1.7163511910991094,"self":"https://pharos.nih.gov/idg/api/v1/targets(3119)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(3119)/properties"},"_links":{"count":1148,"href":"https://pharos.nih.gov/idg/api/v1/targets(3119)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3119)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3119)/publications"},"_namespace":null},{"id":3120,"version":2,"created":1554876025000,"modified":1554876026000,"deprecated":false,"name":"Glutamate-rich protein 4","accession":"A6NGS2","gene":"ERICH4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.89097594393198,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3120)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3120)/properties"},"_links":{"count":628,"href":"https://pharos.nih.gov/idg/api/v1/targets(3120)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3120)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3120)/publications"},"_namespace":null},{"id":3121,"version":3,"created":1554876027000,"modified":1555034537000,"deprecated":false,"name":"Glutathione S-transferase kappa 1","accession":"Q9Y2Q3","gene":"GSTK1","description":"Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.09202485249652,"antibodyCount":253,"monoclonalCount":21,"pubmedCount":null,"jensenScore":12.988585,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":42.60531788958026,"pubTatorScore":3.31251869899714,"self":"https://pharos.nih.gov/idg/api/v1/targets(3121)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":422,"href":"https://pharos.nih.gov/idg/api/v1/targets(3121)/properties"},"_links":{"count":1177,"href":"https://pharos.nih.gov/idg/api/v1/targets(3121)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3121)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(3121)/publications"},"_namespace":null},{"id":3122,"version":2,"created":1554876032000,"modified":1554876034000,"deprecated":false,"name":"BMP-binding endothelial regulator protein","accession":"Q8N8U9","gene":"BMPER","description":"Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.511737028394129,"antibodyCount":120,"monoclonalCount":9,"pubmedCount":null,"jensenScore":317.660722,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.057332895895996,"pubTatorScore":2.117180100816637,"self":"https://pharos.nih.gov/idg/api/v1/targets(3122)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3122)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(3122)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3122)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3122)/publications"},"_namespace":null},{"id":3123,"version":2,"created":1554876035000,"modified":1554876036000,"deprecated":false,"name":"Solute carrier family 10 member 6","accession":"Q3KNW5","gene":"SLC10A6","description":"Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.8966057004789253,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.21379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.969391508571675,"pubTatorScore":0.7972862421043145,"self":"https://pharos.nih.gov/idg/api/v1/targets(3123)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(3123)/properties"},"_links":{"count":704,"href":"https://pharos.nih.gov/idg/api/v1/targets(3123)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3123)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3123)/publications"},"_namespace":null},{"id":3124,"version":3,"created":1554876037000,"modified":1555034539000,"deprecated":false,"name":"39S ribosomal protein L52, mitochondrial","accession":"Q86TS9","gene":"MRPL52","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.705044152458379,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.195708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":32.945185235877865,"pubTatorScore":-1.7159981321322852,"self":"https://pharos.nih.gov/idg/api/v1/targets(3124)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3124)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(3124)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3124)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3124)/publications"},"_namespace":null},{"id":3125,"version":2,"created":1554876040000,"modified":1554876043000,"deprecated":false,"name":"28S ribosomal protein S28, mitochondrial","accession":"Q9Y2Q9","gene":"MRPS28","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":56,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.49819621436551,"pubTatorScore":0.07587857734528743,"self":"https://pharos.nih.gov/idg/api/v1/targets(3125)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(3125)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(3125)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3125)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3125)/publications"},"_namespace":null},{"id":3126,"version":2,"created":1554876043000,"modified":1554876045000,"deprecated":false,"name":"Zinc finger protein 57 homolog","accession":"Q9NU63","gene":"ZFP57","description":"Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6213317939878598,"antibodyCount":136,"monoclonalCount":46,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.96821268418099,"pubTatorScore":1.4647913323653932,"self":"https://pharos.nih.gov/idg/api/v1/targets(3126)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(3126)/properties"},"_links":{"count":618,"href":"https://pharos.nih.gov/idg/api/v1/targets(3126)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3126)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3126)/publications"},"_namespace":null},{"id":3127,"version":2,"created":1554876045000,"modified":1554876047000,"deprecated":false,"name":"Cation channel sperm-associated protein subunit zeta","accession":"Q9NTU4","gene":"CATSPERZ","description":"Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.15490196042003768,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.786765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(3127)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(3127)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(3127)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3127)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3127)/publications"},"_namespace":null},{"id":3128,"version":3,"created":1554876048000,"modified":1555034540000,"deprecated":false,"name":"Neuronal vesicle trafficking-associated protein 2","accession":"Q9Y328","gene":"NSG2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.5774917416417686,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":32.53115,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":0.8823710563259639,"self":"https://pharos.nih.gov/idg/api/v1/targets(3128)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3128)/properties"},"_links":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(3128)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3128)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3128)/publications"},"_namespace":null},{"id":3129,"version":2,"created":1554876049000,"modified":1554876049000,"deprecated":false,"name":"Putative UPF0730 protein encoded by LINC00643","accession":"Q86TS7","gene":"LINC00643","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.493484392650851,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3129)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3129)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3129)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3129)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3129)/publications"},"_namespace":null},{"id":3130,"version":3,"created":1554876049000,"modified":1555034541000,"deprecated":false,"name":"Inositol hexakisphosphate kinase 2","accession":"Q9UHH9","gene":"IP6K2","description":"Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.395637954092221,"antibodyCount":140,"monoclonalCount":28,"pubmedCount":null,"jensenScore":26.120161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.77236332600479,"pubTatorScore":0.9640218112637322,"self":"https://pharos.nih.gov/idg/api/v1/targets(3130)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(3130)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(3130)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(3130)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3130)/publications"},"_namespace":null},{"id":3131,"version":3,"created":1554876052000,"modified":1555034542000,"deprecated":false,"name":"Cerebellin-4","accession":"Q9NTU7","gene":"CBLN4","description":"May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7457809222290265,"antibodyCount":85,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.470005,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":18.068186320664033,"pubTatorScore":0.5067918967070575,"self":"https://pharos.nih.gov/idg/api/v1/targets(3131)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(3131)/properties"},"_links":{"count":661,"href":"https://pharos.nih.gov/idg/api/v1/targets(3131)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3131)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3131)/publications"},"_namespace":null},{"id":3132,"version":3,"created":1554876054000,"modified":1555034543000,"deprecated":false,"name":"Prohibitin-2","accession":"Q99623","gene":"PHB2","description":"Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9534736206518444,"antibodyCount":370,"monoclonalCount":10,"pubmedCount":null,"jensenScore":911.734305,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.76419121893224,"pubTatorScore":2.6533409938202484,"self":"https://pharos.nih.gov/idg/api/v1/targets(3132)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":496,"href":"https://pharos.nih.gov/idg/api/v1/targets(3132)/properties"},"_links":{"count":1221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3132)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3132)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3132)/publications"},"_namespace":null},{"id":3133,"version":2,"created":1554876059000,"modified":1554876059000,"deprecated":false,"name":"Uncharacterized protein C16orf78","accession":"Q8WTQ4","gene":"C16orf78","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3133)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3133)/properties"},"_links":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(3133)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3133)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3133)/publications"},"_namespace":null},{"id":3134,"version":2,"created":1554876059000,"modified":1554876061000,"deprecated":false,"name":"Sodium-coupled neutral amino acid transporter 3","accession":"Q99624","gene":"SLC38A3","description":"Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":null,"antibodyCount":59,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.08544561308517,"pubTatorScore":2.323683419896353,"self":"https://pharos.nih.gov/idg/api/v1/targets(3134)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(3134)/properties"},"_links":{"count":721,"href":"https://pharos.nih.gov/idg/api/v1/targets(3134)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3134)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3134)/publications"},"_namespace":null},{"id":3135,"version":3,"created":1554876062000,"modified":1555034544000,"deprecated":false,"name":"Diphthine--ammonia ligase","accession":"Q7L8W6","gene":"DPH6","description":"Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.46524117695124134,"antibodyCount":31,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.26591,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.77092030029328,"pubTatorScore":0.5058455136865754,"self":"https://pharos.nih.gov/idg/api/v1/targets(3135)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3135)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(3135)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3135)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3135)/publications"},"_namespace":null},{"id":3136,"version":2,"created":1554876064000,"modified":1554876065000,"deprecated":false,"name":"Beta-defensin 104","accession":"Q8WTQ1","gene":"DEFB104B","description":"Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6084024813445832,"antibodyCount":35,"monoclonalCount":7,"pubmedCount":null,"jensenScore":37.99418,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.2223952762775845,"pubTatorScore":1.1525794993247334,"self":"https://pharos.nih.gov/idg/api/v1/targets(3136)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3136)/properties"},"_links":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3136)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3136)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3136)/publications"},"_namespace":null},{"id":3137,"version":3,"created":1554876065000,"modified":1555034546000,"deprecated":false,"name":"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2","accession":"Q7L985","gene":"LINGO2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9722073524593691,"antibodyCount":112,"monoclonalCount":27,"pubmedCount":null,"jensenScore":6.998883,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":26.6757124739908,"pubTatorScore":0.9998911956039637,"self":"https://pharos.nih.gov/idg/api/v1/targets(3137)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3137)/properties"},"_links":{"count":745,"href":"https://pharos.nih.gov/idg/api/v1/targets(3137)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3137)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3137)/publications"},"_namespace":null},{"id":3138,"version":2,"created":1554876068000,"modified":1554876070000,"deprecated":false,"name":"Protein C10","accession":"Q99622","gene":"C12orf57","description":"In brain, may be required for corpus callusum development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.179194496448563,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":144.662459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.174648103552435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(3138)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(3138)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3138)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3138)/publications"},"_namespace":null},{"id":3139,"version":3,"created":1554876071000,"modified":1555034547000,"deprecated":false,"name":"Fibroblast growth factor receptor substrate 2","accession":"Q8WU20","gene":"FRS2","description":"Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.372026147205589,"antibodyCount":344,"monoclonalCount":49,"pubmedCount":null,"jensenScore":224.020045,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.07990570783657,"pubTatorScore":1.861401288459077,"self":"https://pharos.nih.gov/idg/api/v1/targets(3139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(3139)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(3139)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(3139)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3139)/publications"},"_namespace":null},{"id":3140,"version":2,"created":1554876074000,"modified":1554876075000,"deprecated":false,"name":"Uncharacterized protein C20orf144","accession":"Q9BQM9","gene":"C20orf144","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5965970904149265,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.429972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3140)/properties"},"_links":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(3140)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3140)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3140)/publications"},"_namespace":null},{"id":3141,"version":2,"created":1554876075000,"modified":1554876076000,"deprecated":false,"name":"Neurogenic differentiation factor 6","accession":"Q96NK8","gene":"NEUROD6","description":"Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.51922581049045,"antibodyCount":133,"monoclonalCount":17,"pubmedCount":null,"jensenScore":32.778398,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.00614477807741,"pubTatorScore":1.481011674893393,"self":"https://pharos.nih.gov/idg/api/v1/targets(3141)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(3141)/properties"},"_links":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(3141)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3141)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3141)/publications"},"_namespace":null},{"id":3142,"version":3,"created":1554876076000,"modified":1555034548000,"deprecated":false,"name":"Cytochrome c oxidase assembly factor 3 homolog, mitochondrial","accession":"Q9Y2R0","gene":"COA3","description":"Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9311793075856468,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.15517,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":32.725682857435764,"pubTatorScore":0.8377988433351748,"self":"https://pharos.nih.gov/idg/api/v1/targets(3142)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(3142)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(3142)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3142)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3142)/publications"},"_namespace":null},{"id":3143,"version":3,"created":1554876079000,"modified":1555034549000,"deprecated":false,"name":"Zinc finger and BTB domain-containing protein 12","accession":"Q9Y330","gene":"ZBTB12","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1338049656876845,"antibodyCount":76,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.04525,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.832157638325715,"pubTatorScore":0.8888344305471364,"self":"https://pharos.nih.gov/idg/api/v1/targets(3143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(3143)/properties"},"_links":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(3143)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3143)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3143)/publications"},"_namespace":null},{"id":3144,"version":2,"created":1554876082000,"modified":1554876084000,"deprecated":false,"name":"Chromodomain Y-like protein 2","accession":"Q8N8U2","gene":"CDYL2","description":null,"idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.132714458941509,"antibodyCount":61,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.640097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.58047383742516,"pubTatorScore":0.07310734300831032,"self":"https://pharos.nih.gov/idg/api/v1/targets(3144)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3144)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(3144)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3144)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3144)/publications"},"_namespace":null},{"id":3145,"version":3,"created":1554876085000,"modified":1555034551000,"deprecated":false,"name":"COP9 signalosome complex subunit 8","accession":"Q99627","gene":"COPS8","description":"Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2040984421838217,"antibodyCount":166,"monoclonalCount":19,"pubmedCount":null,"jensenScore":15.837357,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":39.03383027533343,"pubTatorScore":1.9656290049621024,"self":"https://pharos.nih.gov/idg/api/v1/targets(3145)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3145)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(3145)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3145)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3145)/publications"},"_namespace":null},{"id":3146,"version":2,"created":1554876088000,"modified":1554876091000,"deprecated":false,"name":"Rhodopsin kinase","accession":"Q8WTQ7","gene":"GRK7","description":"Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.83395668998341,"antibodyCount":180,"monoclonalCount":46,"pubmedCount":null,"jensenScore":45.036495,"patentCount":1559,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.056193150611488,"pubTatorScore":0.8965130451602056,"self":"https://pharos.nih.gov/idg/api/v1/targets(3146)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3146)/properties"},"_links":{"count":737,"href":"https://pharos.nih.gov/idg/api/v1/targets(3146)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3146)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3146)/publications"},"_namespace":null},{"id":3147,"version":2,"created":1554876091000,"modified":1554876092000,"deprecated":false,"name":"Retrotransposon Gag-like protein 3","accession":"Q8N8U3","gene":"RTL3","description":"May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.16272729614052944,"antibodyCount":64,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.809524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.8563259996242113,"self":"https://pharos.nih.gov/idg/api/v1/targets(3147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(3147)/properties"},"_links":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(3147)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3147)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3147)/publications"},"_namespace":null},{"id":3148,"version":2,"created":1554876093000,"modified":1554876096000,"deprecated":false,"name":"Centrosomal protein of 120 kDa","accession":"Q8N960","gene":"CEP120","description":"Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9321452933818714,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.322221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.301504962967066,"pubTatorScore":0.8562343951374193,"self":"https://pharos.nih.gov/idg/api/v1/targets(3148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(3148)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(3148)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3148)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3148)/publications"},"_namespace":null},{"id":3149,"version":2,"created":1554876096000,"modified":1554876099000,"deprecated":false,"name":"Homeobox protein CDX-2","accession":"Q99626","gene":"CDX2","description":"Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.9127262653385744,"antibodyCount":699,"monoclonalCount":273,"pubmedCount":null,"jensenScore":837.014336,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.898754778918,"pubTatorScore":2.7914685877947853,"self":"https://pharos.nih.gov/idg/api/v1/targets(3149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(3149)/properties"},"_links":{"count":697,"href":"https://pharos.nih.gov/idg/api/v1/targets(3149)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3149)/synonyms"},"_publications":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(3149)/publications"},"_namespace":null},{"id":3150,"version":3,"created":1554876100000,"modified":1555034555000,"deprecated":false,"name":"Ankyrin repeat and BTB/POZ domain-containing protein 2","accession":"Q8N961","gene":"ABTB2","description":"May be involved in the initiation of hepatocyte growth.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":60,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":85,"knowledgeAvailability":39.09441035253471,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3150)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(3150)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(3150)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3150)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3150)/publications"},"_namespace":null},{"id":3151,"version":3,"created":1554876102000,"modified":1555034556000,"deprecated":false,"name":"Sialic acid-binding Ig-like lectin 9","accession":"Q9Y336","gene":"SIGLEC9","description":"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6047230686358172,"antibodyCount":385,"monoclonalCount":136,"pubmedCount":null,"jensenScore":44.211619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":19.811676769522474,"pubTatorScore":1.5952145665987945,"self":"https://pharos.nih.gov/idg/api/v1/targets(3151)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(3151)/properties"},"_links":{"count":842,"href":"https://pharos.nih.gov/idg/api/v1/targets(3151)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3151)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3151)/publications"},"_namespace":null},{"id":3152,"version":3,"created":1554876105000,"modified":1555034559000,"deprecated":false,"name":"28S ribosomal protein S17, mitochondrial","accession":"Q9Y2R5","gene":"MRPS17","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.4423591485810879,"antibodyCount":28,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":69,"knowledgeAvailability":31.848441121493853,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(3152)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(3152)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(3152)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3152)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3152)/publications"},"_namespace":null},{"id":3153,"version":2,"created":1554876108000,"modified":1554876110000,"deprecated":false,"name":"G patch domain-containing protein 11","accession":"Q8N954","gene":"GPATCH11","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.14132915134882104,"antibodyCount":105,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.153846,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.54467831880874,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3153)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3153)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(3153)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3153)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3153)/publications"},"_namespace":null},{"id":3154,"version":3,"created":1554876111000,"modified":1555034560000,"deprecated":false,"name":"Kallikrein-5","accession":"Q9Y337","gene":"KLK5","description":"May be involved in desquamation.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.885261614723528,"antibodyCount":263,"monoclonalCount":41,"pubmedCount":null,"jensenScore":81.034099,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":21.366972670014256,"pubTatorScore":1.891714350649849,"self":"https://pharos.nih.gov/idg/api/v1/targets(3154)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(3154)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(3154)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3154)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3154)/publications"},"_namespace":null},{"id":3155,"version":2,"created":1554876117000,"modified":1554876119000,"deprecated":false,"name":"MORN repeat-containing protein 2","accession":"Q502X0","gene":"MORN2","description":"Might have a role in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.190598478162672,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.890872,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.08992875736,"pubTatorScore":0.5228788321392253,"self":"https://pharos.nih.gov/idg/api/v1/targets(3155)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3155)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(3155)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3155)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3155)/publications"},"_namespace":null},{"id":3156,"version":3,"created":1554876120000,"modified":1555034561000,"deprecated":false,"name":"Large neutral amino acids transporter small subunit 2","accession":"Q9UHI5","gene":"SLC7A8","description":"Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.200758384446307,"antibodyCount":126,"monoclonalCount":85,"pubmedCount":null,"jensenScore":18.805195,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.854784340053136,"pubTatorScore":0.8042637032259304,"self":"https://pharos.nih.gov/idg/api/v1/targets(3156)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(3156)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(3156)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3156)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3156)/publications"},"_namespace":null},{"id":3157,"version":3,"created":1554876123000,"modified":1555034563000,"deprecated":false,"name":"Tyrosine-protein phosphatase non-receptor type 22","accession":"Q9Y2R2","gene":"PTPN22","description":"Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.707152715798316,"antibodyCount":211,"monoclonalCount":26,"pubmedCount":null,"jensenScore":543.910373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.809500129400156,"pubTatorScore":3.0970018565788635,"self":"https://pharos.nih.gov/idg/api/v1/targets(3157)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(3157)/properties"},"_links":{"count":1428,"href":"https://pharos.nih.gov/idg/api/v1/targets(3157)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(3157)/synonyms"},"_publications":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(3157)/publications"},"_namespace":null},{"id":3158,"version":3,"created":1554876142000,"modified":1555034566000,"deprecated":false,"name":"Golgi apparatus membrane protein TVP23 homolog A","accession":"A6NH52","gene":"TVP23A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":14.413695395831008,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3158)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(3158)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(3158)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3158)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3158)/publications"},"_namespace":null},{"id":3159,"version":2,"created":1554876145000,"modified":1554876147000,"deprecated":false,"name":"Ankyrin repeat and fibronectin type-III domain-containing protein 1","accession":"Q8N957","gene":"ANKFN1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.06214790530119616,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.708333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.402119537716473,"pubTatorScore":0.37311640450961764,"self":"https://pharos.nih.gov/idg/api/v1/targets(3159)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(3159)/properties"},"_links":{"count":721,"href":"https://pharos.nih.gov/idg/api/v1/targets(3159)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3159)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3159)/publications"},"_namespace":null},{"id":3160,"version":2,"created":1554876148000,"modified":1554876149000,"deprecated":false,"name":"von Willebrand factor A domain-containing protein 7","accession":"Q9Y334","gene":"VWA7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0972407999116405,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.95368,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.220625737146285,"pubTatorScore":0.40369228041711436,"self":"https://pharos.nih.gov/idg/api/v1/targets(3160)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3160)/properties"},"_links":{"count":725,"href":"https://pharos.nih.gov/idg/api/v1/targets(3160)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3160)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3160)/publications"},"_namespace":null},{"id":3161,"version":2,"created":1554876150000,"modified":1554876151000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX52","accession":"Q9Y2R4","gene":"DDX52","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2664462139174397,"antibodyCount":73,"monoclonalCount":0,"pubmedCount":null,"jensenScore":18.017738,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.55806156060939,"pubTatorScore":0.3684328651480656,"self":"https://pharos.nih.gov/idg/api/v1/targets(3161)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(3161)/properties"},"_links":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(3161)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3161)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3161)/publications"},"_namespace":null},{"id":3162,"version":2,"created":1554876151000,"modified":1554876154000,"deprecated":false,"name":"U6 snRNA-associated Sm-like protein LSm2","accession":"Q9Y333","gene":"LSM2","description":"Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.402261386797625,"antibodyCount":121,"monoclonalCount":38,"pubmedCount":null,"jensenScore":22.961646,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.617598473193596,"pubTatorScore":2.5452496645382725,"self":"https://pharos.nih.gov/idg/api/v1/targets(3162)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(3162)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(3162)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3162)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3162)/publications"},"_namespace":null},{"id":3163,"version":2,"created":1554876154000,"modified":1554876158000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 1","accession":"Q9UHI8","gene":"ADAMTS1","description":"Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.444587507880958,"antibodyCount":227,"monoclonalCount":47,"pubmedCount":null,"jensenScore":279.842484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.74323947393302,"pubTatorScore":2.327762183187851,"self":"https://pharos.nih.gov/idg/api/v1/targets(3163)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3163)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(3163)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3163)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3163)/publications"},"_namespace":null},{"id":3164,"version":2,"created":1554876159000,"modified":1554876162000,"deprecated":false,"name":"Solute carrier family 23 member 1","accession":"Q9UHI7","gene":"SLC23A1","description":"Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.82531349201872,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":64.01378,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.24495401377141,"pubTatorScore":1.792338870473652,"self":"https://pharos.nih.gov/idg/api/v1/targets(3164)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3164)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(3164)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3164)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3164)/publications"},"_namespace":null},{"id":3165,"version":3,"created":1554876163000,"modified":1555034567000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX20","accession":"Q9UHI6","gene":"DDX20","description":"The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5824884498586964,"antibodyCount":250,"monoclonalCount":82,"pubmedCount":null,"jensenScore":38.043926,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":45.06576823588564,"pubTatorScore":1.4787220923114122,"self":"https://pharos.nih.gov/idg/api/v1/targets(3165)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(3165)/properties"},"_links":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(3165)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3165)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3165)/publications"},"_namespace":null},{"id":3166,"version":2,"created":1554876167000,"modified":1554876169000,"deprecated":false,"name":"Nucleolar protein 9","accession":"Q86U38","gene":"NOP9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":27,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.94044954491164,"pubTatorScore":0.3521825181113625,"self":"https://pharos.nih.gov/idg/api/v1/targets(3166)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(3166)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(3166)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3166)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3166)/publications"},"_namespace":null},{"id":3167,"version":2,"created":1554876170000,"modified":1554876172000,"deprecated":false,"name":"Polycomb group RING finger protein 3","accession":"Q3KNV8","gene":"PCGF3","description":"Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.48328156032237746,"antibodyCount":115,"monoclonalCount":9,"pubmedCount":null,"jensenScore":1.972138,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.22104838496212,"pubTatorScore":0.3207395550311959,"self":"https://pharos.nih.gov/idg/api/v1/targets(3167)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(3167)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(3167)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3167)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3167)/publications"},"_namespace":null},{"id":3168,"version":3,"created":1554876172000,"modified":1555034569000,"deprecated":false,"name":"28S ribosomal protein S7, mitochondrial","accession":"Q9Y2R9","gene":"MRPS7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7888767878123906,"antibodyCount":71,"monoclonalCount":32,"pubmedCount":null,"jensenScore":575.97968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":35.64974543619121,"pubTatorScore":0.8768473998206201,"self":"https://pharos.nih.gov/idg/api/v1/targets(3168)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(3168)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(3168)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3168)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3168)/publications"},"_namespace":null},{"id":3169,"version":2,"created":1554876176000,"modified":1554876176000,"deprecated":false,"name":"Uncharacterized protein encoded by LINC01551","accession":"Q86U37","gene":"LINC01551","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.768688263422591,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3169)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3169)/properties"},"_links":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3169)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3169)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3169)/publications"},"_namespace":null},{"id":3170,"version":2,"created":1554876176000,"modified":1554876179000,"deprecated":false,"name":"Krueppel-like factor 6","accession":"Q99612","gene":"KLF6","description":"Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3730368718972836,"antibodyCount":161,"monoclonalCount":34,"pubmedCount":null,"jensenScore":253.616805,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.43697910968865,"pubTatorScore":2.3814731149777564,"self":"https://pharos.nih.gov/idg/api/v1/targets(3170)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(3170)/properties"},"_links":{"count":1134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3170)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3170)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(3170)/publications"},"_namespace":null},{"id":3171,"version":2,"created":1554876180000,"modified":1554876183000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit C","accession":"Q99613","gene":"EIF3C","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.206796938217453,"antibodyCount":159,"monoclonalCount":3,"pubmedCount":null,"jensenScore":14.095801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.29878114443035,"pubTatorScore":0.949185693795298,"self":"https://pharos.nih.gov/idg/api/v1/targets(3171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(3171)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(3171)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(3171)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3171)/publications"},"_namespace":null},{"id":3172,"version":2,"created":1554876184000,"modified":1554876186000,"deprecated":false,"name":"Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1","accession":"Q8WU10","gene":"PYROXD1","description":"Involved in cellular response to oxidative stress.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.3631779028471202,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.196429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.564214678973222,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(3172)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(3172)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3172)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3172)/publications"},"_namespace":null},{"id":3173,"version":2,"created":1554876186000,"modified":1554876186000,"deprecated":false,"name":"Uncharacterized protein FLJ30774","accession":"Q96NJ1","gene":"C9orf163","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3173)/properties"},"_links":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3173)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3173)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3173)/publications"},"_namespace":null},{"id":3174,"version":2,"created":1554876186000,"modified":1554876189000,"deprecated":false,"name":"Selenide, water dikinase 2","accession":"Q99611","gene":"SEPHS2","description":"Synthesizes selenophosphate from selenide and ATP.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.4267135776624225,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":25.303665,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.693223114064295,"pubTatorScore":1.0829172178978352,"self":"https://pharos.nih.gov/idg/api/v1/targets(3174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(3174)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(3174)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3174)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3174)/publications"},"_namespace":null},{"id":3175,"version":3,"created":1554876189000,"modified":1555034571000,"deprecated":false,"name":"Zinc finger protein SNAI3","accession":"Q3KNW1","gene":"SNAI3","description":"Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0219463192241873,"antibodyCount":94,"monoclonalCount":1,"pubmedCount":null,"jensenScore":9.054505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.06759442378523,"pubTatorScore":0.9199337508744981,"self":"https://pharos.nih.gov/idg/api/v1/targets(3175)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(3175)/properties"},"_links":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(3175)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3175)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3175)/publications"},"_namespace":null},{"id":3176,"version":2,"created":1554876192000,"modified":1554876193000,"deprecated":false,"name":"Putative ADP-ribosylation factor-like protein 5C","accession":"A6NH57","gene":"ARL5C","description":"Binds and exchanges GTP and GDP.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.0,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.93062879968877,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3176)/properties"},"_links":{"count":604,"href":"https://pharos.nih.gov/idg/api/v1/targets(3176)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3176)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3176)/publications"},"_namespace":null},{"id":3177,"version":2,"created":1554876194000,"modified":1554876196000,"deprecated":false,"name":"Zinc finger protein 3 homolog","accession":"Q96NJ6","gene":"ZFP3","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.1484717813668103,"antibodyCount":30,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.381819,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.051045406163404,"pubTatorScore":-0.22847939532991027,"self":"https://pharos.nih.gov/idg/api/v1/targets(3177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(3177)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(3177)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3177)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3177)/publications"},"_namespace":null},{"id":3178,"version":3,"created":1554876196000,"modified":1555034572000,"deprecated":false,"name":"Cell division cycle-associated protein 3","accession":"Q99618","gene":"CDCA3","description":"F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6954399820522088,"antibodyCount":140,"monoclonalCount":27,"pubmedCount":null,"jensenScore":5.15986,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.83330436094073,"pubTatorScore":0.8466463285771175,"self":"https://pharos.nih.gov/idg/api/v1/targets(3178)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3178)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(3178)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3178)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3178)/publications"},"_namespace":null},{"id":3179,"version":3,"created":1554876199000,"modified":1555034573000,"deprecated":false,"name":"Apoptosis-enhancing nuclease","accession":"Q8WTP8","gene":"AEN","description":"Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6565967241203166,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":43.706275,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.93560595612648,"pubTatorScore":0.6344545975832107,"self":"https://pharos.nih.gov/idg/api/v1/targets(3179)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3179)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(3179)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3179)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3179)/publications"},"_namespace":null},{"id":3180,"version":3,"created":1554876202000,"modified":1555034574000,"deprecated":false,"name":"Fermitin family homolog 1","accession":"Q9BQL6","gene":"FERMT1","description":"Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9684121990600407,"antibodyCount":159,"monoclonalCount":46,"pubmedCount":null,"jensenScore":97.724384,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":36.49047172406236,"pubTatorScore":2.0105255021706236,"self":"https://pharos.nih.gov/idg/api/v1/targets(3180)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(3180)/properties"},"_links":{"count":1138,"href":"https://pharos.nih.gov/idg/api/v1/targets(3180)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3180)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3180)/publications"},"_namespace":null},{"id":3181,"version":3,"created":1554876206000,"modified":1555034575000,"deprecated":false,"name":"X antigen family member 3","accession":"Q8WTP9","gene":"XAGE3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5910646009463765,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.382576,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":10.435456330143337,"pubTatorScore":0.10833936198506207,"self":"https://pharos.nih.gov/idg/api/v1/targets(3181)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3181)/properties"},"_links":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(3181)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3181)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3181)/publications"},"_namespace":null},{"id":3182,"version":3,"created":1554876207000,"modified":1555034576000,"deprecated":false,"name":"SPRY domain-containing SOCS box protein 2","accession":"Q99619","gene":"SPSB2","description":"Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.005361007875463,"antibodyCount":81,"monoclonalCount":38,"pubmedCount":null,"jensenScore":11.412594,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":26.693451715688326,"pubTatorScore":0.8696936454789196,"self":"https://pharos.nih.gov/idg/api/v1/targets(3182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3182)/properties"},"_links":{"count":757,"href":"https://pharos.nih.gov/idg/api/v1/targets(3182)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3182)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3182)/publications"},"_namespace":null},{"id":3183,"version":2,"created":1554876209000,"modified":1554876211000,"deprecated":false,"name":"Coiled-coil domain-containing protein 38","accession":"Q502W7","gene":"CCDC38","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.33994805898001035,"antibodyCount":125,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.173611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.548689251157832,"pubTatorScore":0.4452148760562171,"self":"https://pharos.nih.gov/idg/api/v1/targets(3183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(3183)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(3183)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3183)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3183)/publications"},"_namespace":null},{"id":3184,"version":2,"created":1554876211000,"modified":1554876213000,"deprecated":false,"name":"C-C motif chemokine 13","accession":"Q99616","gene":"CCL13","description":"Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0263956080423227,"antibodyCount":264,"monoclonalCount":84,"pubmedCount":null,"jensenScore":99.20376,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.232547850000515,"pubTatorScore":1.9251725790702354,"self":"https://pharos.nih.gov/idg/api/v1/targets(3184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(3184)/properties"},"_links":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(3184)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3184)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3184)/publications"},"_namespace":null},{"id":3185,"version":2,"created":1554876214000,"modified":1554876216000,"deprecated":false,"name":"Zinc finger protein 285","accession":"Q96NJ3","gene":"ZNF285","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.51612160864417,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(3185)/properties"},"_links":{"count":725,"href":"https://pharos.nih.gov/idg/api/v1/targets(3185)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3185)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3185)/publications"},"_namespace":null},{"id":3186,"version":2,"created":1554876216000,"modified":1554876218000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF139","accession":"Q8WU17","gene":"RNF139","description":"E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1716855500337175,"antibodyCount":133,"monoclonalCount":39,"pubmedCount":null,"jensenScore":16.618307,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.18859468211738,"pubTatorScore":1.2212629779063577,"self":"https://pharos.nih.gov/idg/api/v1/targets(3186)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(3186)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(3186)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3186)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3186)/publications"},"_namespace":null},{"id":3187,"version":2,"created":1554876219000,"modified":1554876221000,"deprecated":false,"name":"Kelch-like protein 32","accession":"Q96NJ5","gene":"KLHL32","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":64,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.583333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.91804445404331,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3187)/properties"},"_links":{"count":770,"href":"https://pharos.nih.gov/idg/api/v1/targets(3187)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3187)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3187)/publications"},"_namespace":null},{"id":3188,"version":3,"created":1554876222000,"modified":1555034577000,"deprecated":false,"name":"Tetratricopeptide repeat protein 1","accession":"Q99614","gene":"TTC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5256823152303296,"antibodyCount":134,"monoclonalCount":32,"pubmedCount":null,"jensenScore":32.313733,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.98221878024625,"pubTatorScore":1.4053016304933406,"self":"https://pharos.nih.gov/idg/api/v1/targets(3188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3188)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(3188)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3188)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3188)/publications"},"_namespace":null},{"id":3189,"version":3,"created":1554876225000,"modified":1555034579000,"deprecated":false,"name":"von Willebrand factor A domain-containing protein 3B","accession":"Q502W6","gene":"VWA3B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":21.420815793020722,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(3189)/properties"},"_links":{"count":724,"href":"https://pharos.nih.gov/idg/api/v1/targets(3189)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3189)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3189)/publications"},"_namespace":null},{"id":3190,"version":3,"created":1554876227000,"modified":1555034580000,"deprecated":false,"name":"DnaJ homolog subfamily C member 7","accession":"Q99615","gene":"DNAJC7","description":"Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2789456493426088,"antibodyCount":163,"monoclonalCount":17,"pubmedCount":null,"jensenScore":15.941349,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":34,"knowledgeAvailability":38.51770668664325,"pubTatorScore":1.194299555826447,"self":"https://pharos.nih.gov/idg/api/v1/targets(3190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(3190)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(3190)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3190)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3190)/publications"},"_namespace":null},{"id":3191,"version":3,"created":1554876230000,"modified":1555034581000,"deprecated":false,"name":"Mitochondrial 2-oxodicarboxylate carrier","accession":"Q9BQT8","gene":"SLC25A21","description":"Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.7135438670896125,"antibodyCount":112,"monoclonalCount":20,"pubmedCount":null,"jensenScore":3.683134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.02432421854865,"pubTatorScore":0.5273536429732856,"self":"https://pharos.nih.gov/idg/api/v1/targets(3191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(3191)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(3191)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3191)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3191)/publications"},"_namespace":null},{"id":3192,"version":2,"created":1554876233000,"modified":1554876234000,"deprecated":false,"name":"Immunoglobulin kappa variable 3-11","accession":"P04433","gene":"IGKV3-11","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.041434265137657,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3192)/properties"},"_links":{"count":542,"href":"https://pharos.nih.gov/idg/api/v1/targets(3192)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3192)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3192)/publications"},"_namespace":null},{"id":3193,"version":2,"created":1554876235000,"modified":1554876237000,"deprecated":false,"name":"Zinc finger and BTB domain-containing protein 1","accession":"Q9Y2K1","gene":"ZBTB1","description":"Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.6676752593269718,"antibodyCount":59,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.747631,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.74630146540977,"pubTatorScore":0.4445651687526213,"self":"https://pharos.nih.gov/idg/api/v1/targets(3193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(3193)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(3193)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3193)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3193)/publications"},"_namespace":null},{"id":3194,"version":2,"created":1554876238000,"modified":1554876238000,"deprecated":false,"name":"T-cell receptor beta chain V region CTL-L17","accession":"P04435","gene":"TCRB","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3194)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3194)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3194)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3194)/publications"},"_namespace":null},{"id":3195,"version":3,"created":1554876238000,"modified":1555034582000,"deprecated":false,"name":"T-cell receptor alpha chain V region HPB-MLT","accession":"P04436","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3195)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3195)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3195)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3195)/publications"},"_namespace":null},{"id":3196,"version":3,"created":1554876238000,"modified":1555034582000,"deprecated":false,"name":"T-cell receptor alpha chain V region CTL-L17","accession":"P04437","gene":"TCRA","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3196)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3196)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3196)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3196)/publications"},"_namespace":null},{"id":3197,"version":3,"created":1554876238000,"modified":1555034584000,"deprecated":false,"name":"HLA class I histocompatibility antigen, A-3 alpha chain","accession":"P04439","gene":"HLA-A","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.416669710281058,"antibodyCount":686,"monoclonalCount":590,"pubmedCount":null,"jensenScore":4123.756732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":3.457240582152559,"self":"https://pharos.nih.gov/idg/api/v1/targets(3197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1462,"href":"https://pharos.nih.gov/idg/api/v1/targets(3197)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(3197)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3197)/synonyms"},"_publications":{"count":1223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3197)/publications"},"_namespace":null},{"id":3198,"version":2,"created":1554876247000,"modified":1554876248000,"deprecated":false,"name":"Putative glutathione hydrolase 3 proenzyme","accession":"A6NGU5","gene":"GGT3P","description":"Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-3.091928025316767,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1683.242627,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.365111920270049,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3198)/properties"},"_links":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(3198)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3198)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3198)/publications"},"_namespace":null},{"id":3199,"version":2,"created":1554876248000,"modified":1554876250000,"deprecated":false,"name":"Calsyntenin-3","accession":"Q9BQT9","gene":"CLSTN3","description":"May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8135819244738088,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.831681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.723098524925966,"pubTatorScore":0.5222578250940141,"self":"https://pharos.nih.gov/idg/api/v1/targets(3199)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(3199)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(3199)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3199)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3199)/publications"},"_namespace":null},{"id":3200,"version":2,"created":1554876251000,"modified":1554876260000,"deprecated":false,"name":"Lysine-specific demethylase 2A","accession":"Q9Y2K7","gene":"KDM2A","description":"Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.51860711038056,"antibodyCount":183,"monoclonalCount":6,"pubmedCount":null,"jensenScore":36.273047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.88256136627257,"pubTatorScore":1.5511279517131145,"self":"https://pharos.nih.gov/idg/api/v1/targets(3200)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(3200)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3200)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(3200)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3200)/publications"},"_namespace":null},{"id":3201,"version":3,"created":1554876261000,"modified":1555034590000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 20","accession":"Q9Y2K6","gene":"USP20","description":"Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0514907958379176,"antibodyCount":257,"monoclonalCount":7,"pubmedCount":null,"jensenScore":12.685284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.94519351745797,"pubTatorScore":0.9991002092408052,"self":"https://pharos.nih.gov/idg/api/v1/targets(3201)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3201)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(3201)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3201)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3201)/publications"},"_namespace":null},{"id":3202,"version":2,"created":1554876264000,"modified":1554876266000,"deprecated":false,"name":"Syntaxin-binding protein 5-like","accession":"Q9Y2K9","gene":"STXBP5L","description":"May play a role in vesicle trafficking and exocytosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7149414933882822,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.161687,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.691099943975715,"pubTatorScore":0.5576407179104576,"self":"https://pharos.nih.gov/idg/api/v1/targets(3202)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3202)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(3202)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3202)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3202)/publications"},"_namespace":null},{"id":3203,"version":2,"created":1554876266000,"modified":1554876269000,"deprecated":false,"name":"Zinc finger CCCH domain-containing protein 15","accession":"Q8WU90","gene":"ZC3H15","description":"Protects DRG1 from proteolytic degradation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8129133675002178,"antibodyCount":91,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.333712,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.99967170978939,"pubTatorScore":0.5835765478692101,"self":"https://pharos.nih.gov/idg/api/v1/targets(3203)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(3203)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(3203)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3203)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3203)/publications"},"_namespace":null},{"id":3204,"version":2,"created":1554876270000,"modified":1554876270000,"deprecated":false,"name":"Proline-rich protein 33","accession":"A8MZF0","gene":"PRR33","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.6051986721449665,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3204)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3204)/properties"},"_links":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3204)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3204)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3204)/publications"},"_namespace":null},{"id":3205,"version":2,"created":1554876270000,"modified":1554876272000,"deprecated":false,"name":"Zinc finger protein 823","accession":"P16415","gene":"ZNF823","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.10187343388197125,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.483766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.595851609734858,"pubTatorScore":-0.23408345420171428,"self":"https://pharos.nih.gov/idg/api/v1/targets(3205)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3205)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(3205)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3205)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3205)/publications"},"_namespace":null},{"id":3206,"version":2,"created":1554876273000,"modified":1554876275000,"deprecated":false,"name":"Myosin-15","accession":"Q9Y2K3","gene":"MYH15","description":"Muscle contraction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9577975976808555,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.007857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.258528637020444,"pubTatorScore":0.5216926322718178,"self":"https://pharos.nih.gov/idg/api/v1/targets(3206)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(3206)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(3206)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3206)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3206)/publications"},"_namespace":null},{"id":3207,"version":2,"created":1554876275000,"modified":1554876278000,"deprecated":false,"name":"LIM domain and actin-binding protein 1","accession":"Q9UHB6","gene":"LIMA1","description":"Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2688020339018193,"antibodyCount":187,"monoclonalCount":25,"pubmedCount":null,"jensenScore":23.595753,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.079059156356,"pubTatorScore":1.4701306381444526,"self":"https://pharos.nih.gov/idg/api/v1/targets(3207)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(3207)/properties"},"_links":{"count":1160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3207)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3207)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3207)/publications"},"_namespace":null},{"id":3208,"version":2,"created":1554876280000,"modified":1554876284000,"deprecated":false,"name":"Serine/threonine-protein kinase SIK3","accession":"Q9Y2K2","gene":"SIK3","description":null,"idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.1828646427571257,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":18.165718,"patentCount":11961,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.38143086656185,"pubTatorScore":0.6185876470133739,"self":"https://pharos.nih.gov/idg/api/v1/targets(3208)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(3208)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(3208)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3208)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3208)/publications"},"_namespace":null},{"id":3209,"version":3,"created":1554876285000,"modified":1555034591000,"deprecated":false,"name":"NADPH-dependent diflavin oxidoreductase 1","accession":"Q9UHB4","gene":"NDOR1","description":"Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7336207482448455,"antibodyCount":159,"monoclonalCount":57,"pubmedCount":null,"jensenScore":5.148729,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":32.65586223673038,"pubTatorScore":0.9584349134904027,"self":"https://pharos.nih.gov/idg/api/v1/targets(3209)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(3209)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(3209)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3209)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3209)/publications"},"_namespace":null},{"id":3210,"version":2,"created":1554876288000,"modified":1554876291000,"deprecated":false,"name":"R3H domain-containing protein 2","accession":"Q9Y2K5","gene":"R3HDM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8211858717514835,"antibodyCount":39,"monoclonalCount":1,"pubmedCount":null,"jensenScore":4.927619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.7096433280911,"pubTatorScore":0.8488729771116752,"self":"https://pharos.nih.gov/idg/api/v1/targets(3210)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3210)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(3210)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3210)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3210)/publications"},"_namespace":null},{"id":3211,"version":4,"created":1554876291000,"modified":1555034594000,"deprecated":false,"name":"Tryptophan 5-hydroxylase 1","accession":"P17752","gene":"TPH1","description":null,"idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.9303614982693014,"antibodyCount":415,"monoclonalCount":39,"pubmedCount":null,"jensenScore":772.289604,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":34.66807910147038,"pubTatorScore":2.2788465848754096,"self":"https://pharos.nih.gov/idg/api/v1/targets(3211)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":565,"href":"https://pharos.nih.gov/idg/api/v1/targets(3211)/properties"},"_links":{"count":1147,"href":"https://pharos.nih.gov/idg/api/v1/targets(3211)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3211)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(3211)/publications"},"_namespace":null},{"id":3212,"version":3,"created":1554876340000,"modified":1555034597000,"deprecated":false,"name":"Fasciculation and elongation protein zeta-1","accession":"Q99689","gene":"FEZ1","description":"May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3657782426944716,"antibodyCount":142,"monoclonalCount":3,"pubmedCount":null,"jensenScore":25.039892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":36.28894640646637,"pubTatorScore":1.6082508861325662,"self":"https://pharos.nih.gov/idg/api/v1/targets(3212)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(3212)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(3212)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3212)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3212)/publications"},"_namespace":null},{"id":3213,"version":3,"created":1554876344000,"modified":1555034598000,"deprecated":false,"name":"Rho GTPase-activating protein 17","accession":"Q68EM7","gene":"ARHGAP17","description":"Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.81815841210021,"antibodyCount":121,"monoclonalCount":2,"pubmedCount":null,"jensenScore":63.616629,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.74967908118681,"pubTatorScore":1.0347957661178542,"self":"https://pharos.nih.gov/idg/api/v1/targets(3213)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(3213)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(3213)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3213)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3213)/publications"},"_namespace":null},{"id":3214,"version":2,"created":1554876347000,"modified":1554876351000,"deprecated":false,"name":"Epithelial cell adhesion molecule","accession":"P16422","gene":"EPCAM","description":"May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.20357832106908,"antibodyCount":2244,"monoclonalCount":1702,"pubmedCount":null,"jensenScore":1618.555084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.43555325015458,"pubTatorScore":2.9614596316014254,"self":"https://pharos.nih.gov/idg/api/v1/targets(3214)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(3214)/properties"},"_links":{"count":1292,"href":"https://pharos.nih.gov/idg/api/v1/targets(3214)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(3214)/synonyms"},"_publications":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(3214)/publications"},"_namespace":null},{"id":3215,"version":3,"created":1554876353000,"modified":1555034600000,"deprecated":false,"name":"Ankyrin repeat and EF-hand domain-containing protein 1","accession":"Q9NU02","gene":"ANKEF1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.11471957096129837,"antibodyCount":83,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.517857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":25.366602448088393,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(3215)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(3215)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3215)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3215)/publications"},"_namespace":null},{"id":3216,"version":3,"created":1554876355000,"modified":1555034601000,"deprecated":false,"name":"Signal recognition particle subunit SRP68","accession":"Q9UHB9","gene":"SRP68","description":"Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.139916534623135,"antibodyCount":83,"monoclonalCount":13,"pubmedCount":null,"jensenScore":13.381096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":36.95092688646181,"pubTatorScore":1.1782115698361242,"self":"https://pharos.nih.gov/idg/api/v1/targets(3216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(3216)/properties"},"_links":{"count":1121,"href":"https://pharos.nih.gov/idg/api/v1/targets(3216)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3216)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3216)/publications"},"_namespace":null},{"id":3217,"version":3,"created":1554876359000,"modified":1555034603000,"deprecated":false,"name":"Roquin-2","accession":"Q9HBD1","gene":"RC3H2","description":"Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7865148096702658,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.132936,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.78906411757626,"pubTatorScore":0.5388668088047568,"self":"https://pharos.nih.gov/idg/api/v1/targets(3217)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(3217)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(3217)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3217)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3217)/publications"},"_namespace":null},{"id":3218,"version":2,"created":1554876362000,"modified":1554876364000,"deprecated":false,"name":"Homeobox protein Meis3","accession":"Q99687","gene":"MEIS3","description":"Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.8995208603722025,"antibodyCount":256,"monoclonalCount":158,"pubmedCount":null,"jensenScore":8.376546,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.296082690922493,"pubTatorScore":0.33291914968574776,"self":"https://pharos.nih.gov/idg/api/v1/targets(3218)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3218)/properties"},"_links":{"count":831,"href":"https://pharos.nih.gov/idg/api/v1/targets(3218)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3218)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3218)/publications"},"_namespace":null},{"id":3219,"version":3,"created":1554876364000,"modified":1555034605000,"deprecated":false,"name":"Interleukin-12 receptor subunit beta-1","accession":"P42701","gene":"IL12RB1","description":"Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.335315725093299,"antibodyCount":273,"monoclonalCount":58,"pubmedCount":null,"jensenScore":220.945647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":34.97805139842503,"pubTatorScore":2.120945035166852,"self":"https://pharos.nih.gov/idg/api/v1/targets(3219)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(3219)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(3219)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3219)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3219)/publications"},"_namespace":null},{"id":3220,"version":2,"created":1554876369000,"modified":1554876373000,"deprecated":false,"name":"Leukemia inhibitory factor receptor","accession":"P42702","gene":"LIFR","description":"Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3514643548601164,"antibodyCount":249,"monoclonalCount":113,"pubmedCount":null,"jensenScore":221.272562,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.54763973468611,"pubTatorScore":2.0420409186486563,"self":"https://pharos.nih.gov/idg/api/v1/targets(3220)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(3220)/properties"},"_links":{"count":1150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3220)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3220)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3220)/publications"},"_namespace":null},{"id":3221,"version":3,"created":1554876374000,"modified":1555034608000,"deprecated":false,"name":"AF4/FMR2 family member 4","accession":"Q9UHB7","gene":"AFF4","description":"Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5499388185996494,"antibodyCount":174,"monoclonalCount":11,"pubmedCount":null,"jensenScore":350.760078,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":44.61459260513543,"pubTatorScore":1.2470960385355943,"self":"https://pharos.nih.gov/idg/api/v1/targets(3221)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(3221)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(3221)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3221)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3221)/publications"},"_namespace":null},{"id":3222,"version":4,"created":1554876379000,"modified":1555034609000,"deprecated":false,"name":"Monoglyceride lipase","accession":"Q99685","gene":"MGLL","description":"Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.4836722380752723,"antibodyCount":296,"monoclonalCount":101,"pubmedCount":null,"jensenScore":314.713389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.57939907206446,"pubTatorScore":2.282518751179095,"self":"https://pharos.nih.gov/idg/api/v1/targets(3222)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(3222)/properties"},"_links":{"count":1333,"href":"https://pharos.nih.gov/idg/api/v1/targets(3222)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(3222)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(3222)/publications"},"_namespace":null},{"id":3223,"version":3,"created":1554876446000,"modified":1555034611000,"deprecated":false,"name":"Protein TMED8","accession":"Q6PL24","gene":"TMED8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":20.195908295689378,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3223)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(3223)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(3223)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3223)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3223)/publications"},"_namespace":null},{"id":3224,"version":2,"created":1554876449000,"modified":1554876452000,"deprecated":false,"name":"Leucine-rich PPR motif-containing protein, mitochondrial","accession":"P42704","gene":"LRPPRC","description":"May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.674337202232873,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":54.112134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.73943426974502,"pubTatorScore":1.6206159507117543,"self":"https://pharos.nih.gov/idg/api/v1/targets(3224)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(3224)/properties"},"_links":{"count":1272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3224)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3224)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3224)/publications"},"_namespace":null},{"id":3225,"version":2,"created":1554876453000,"modified":1554876456000,"deprecated":false,"name":"Conserved oligomeric Golgi complex subunit 1","accession":"Q8WTW3","gene":"COG1","description":"Required for normal Golgi function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6806613377937418,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":45.639643,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.987757926717045,"pubTatorScore":1.6023515222020204,"self":"https://pharos.nih.gov/idg/api/v1/targets(3225)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(3225)/properties"},"_links":{"count":1114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3225)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3225)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3225)/publications"},"_namespace":null},{"id":3226,"version":3,"created":1554876457000,"modified":1555034612000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 5","accession":"Q99683","gene":"MAP3K5","description":"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.6622253657590313,"antibodyCount":1185,"monoclonalCount":63,"pubmedCount":null,"jensenScore":525.41695,"patentCount":19893,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":56.6801059004009,"pubTatorScore":2.4603500564657974,"self":"https://pharos.nih.gov/idg/api/v1/targets(3226)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":692,"href":"https://pharos.nih.gov/idg/api/v1/targets(3226)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(3226)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3226)/synonyms"},"_publications":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3226)/publications"},"_namespace":null},{"id":3227,"version":3,"created":1554876478000,"modified":1555034615000,"deprecated":false,"name":"GATOR complex protein NPRL2","accession":"Q8WTW4","gene":"NPRL2","description":"Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3062385023025385,"antibodyCount":214,"monoclonalCount":3,"pubmedCount":null,"jensenScore":22.663286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":28.71153112436373,"pubTatorScore":1.2582788538798417,"self":"https://pharos.nih.gov/idg/api/v1/targets(3227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(3227)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(3227)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3227)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3227)/publications"},"_namespace":null},{"id":3228,"version":2,"created":1554876482000,"modified":1554876484000,"deprecated":false,"name":"Zinc finger protein Gfi-1","accession":"Q99684","gene":"GFI1","description":"Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2078290161886645,"antibodyCount":176,"monoclonalCount":70,"pubmedCount":null,"jensenScore":172.723269,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.16217723791701,"pubTatorScore":2.1956296890772684,"self":"https://pharos.nih.gov/idg/api/v1/targets(3228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3228)/publications"},"_namespace":null},{"id":3229,"version":2,"created":1554876485000,"modified":1554876485000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC01546","accession":"A6NGU7","gene":"LINC01546","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.40539003260517,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/properties"},"_links":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3229)/publications"},"_namespace":null},{"id":3230,"version":3,"created":1554876485000,"modified":1555034616000,"deprecated":false,"name":"2'-5'-oligoadenylate synthase 2","accession":"P29728","gene":"OAS2","description":"Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4149617003490071,"antibodyCount":293,"monoclonalCount":131,"pubmedCount":null,"jensenScore":20.840618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.234737278769295,"pubTatorScore":1.2566597640342612,"self":"https://pharos.nih.gov/idg/api/v1/targets(3230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3230)/publications"},"_namespace":null},{"id":3231,"version":3,"created":1554876489000,"modified":1555034618000,"deprecated":false,"name":"Tetratricopeptide repeat protein 6","accession":"Q86TZ1","gene":"TTC6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2688453129607253,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.571429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":10.555409659497569,"pubTatorScore":-0.024823788098954087,"self":"https://pharos.nih.gov/idg/api/v1/targets(3231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/properties"},"_links":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3231)/publications"},"_namespace":null},{"id":3232,"version":3,"created":1554876491000,"modified":1555034619000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DP beta 1 chain","accession":"P04440","gene":"HLA-DPB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6921938624792503,"antibodyCount":321,"monoclonalCount":148,"pubmedCount":null,"jensenScore":594.429944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":37.417493663890376,"pubTatorScore":2.1559791156840262,"self":"https://pharos.nih.gov/idg/api/v1/targets(3232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/properties"},"_links":{"count":1282,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/links"},"_synonyms":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/synonyms"},"_publications":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(3232)/publications"},"_namespace":null},{"id":3233,"version":3,"created":1554876497000,"modified":1554876584000,"deprecated":false,"name":"Protein kinase C beta type","accession":"P05771","gene":"PRKCB","description":"Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.0043722630484933,"antibodyCount":598,"monoclonalCount":71,"pubmedCount":null,"jensenScore":93.477696,"patentCount":10807,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":54.54878349827856,"pubTatorScore":2.5841151758603984,"self":"https://pharos.nih.gov/idg/api/v1/targets(3233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/properties"},"_links":{"count":1450,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/synonyms"},"_publications":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(3233)/publications"},"_namespace":null},{"id":3234,"version":2,"created":1554876586000,"modified":1554876588000,"deprecated":false,"name":"Hephaestin","accession":"Q9BQS7","gene":"HEPH","description":"May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.025354769576797,"antibodyCount":111,"monoclonalCount":36,"pubmedCount":null,"jensenScore":102.708136,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.59688151704589,"pubTatorScore":1.7030865578297858,"self":"https://pharos.nih.gov/idg/api/v1/targets(3234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3234)/publications"},"_namespace":null},{"id":3235,"version":2,"created":1554876589000,"modified":1554876589000,"deprecated":false,"name":"Immunoglobulin heavy variable 5-10-1","accession":"A0A0J9YXX1","gene":"IGHV5-10-1","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3235)/publications"},"_namespace":null},{"id":3236,"version":3,"created":1554876589000,"modified":1555034623000,"deprecated":false,"name":"Heat shock protein beta-9","accession":"Q9BQS6","gene":"HSPB9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8226166411218366,"antibodyCount":75,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.540554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":17.71891418198396,"pubTatorScore":0.5652574615955669,"self":"https://pharos.nih.gov/idg/api/v1/targets(3236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/properties"},"_links":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3236)/publications"},"_namespace":null},{"id":3237,"version":2,"created":1554876590000,"modified":1554876590000,"deprecated":false,"name":"Putative uncharacterized protein C20orf78","accession":"Q9BR46","gene":"C20orf78","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/properties"},"_links":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3237)/publications"},"_namespace":null},{"id":3238,"version":2,"created":1554876590000,"modified":1554876593000,"deprecated":false,"name":"Exosome complex exonuclease RRP44","accession":"Q9Y2L1","gene":"DIS3","description":"Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8072962586782289,"antibodyCount":141,"monoclonalCount":20,"pubmedCount":null,"jensenScore":64.210099,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.9129747937233,"pubTatorScore":1.4477475735399699,"self":"https://pharos.nih.gov/idg/api/v1/targets(3238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3238)/publications"},"_namespace":null},{"id":3239,"version":3,"created":1554876594000,"modified":1555034623000,"deprecated":false,"name":"Glutathione S-transferase theta-1","accession":"P30711","gene":"GSTT1","description":"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.934050750754407,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":876.119048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":34.13956151234976,"pubTatorScore":3.1499894849610848,"self":"https://pharos.nih.gov/idg/api/v1/targets(3239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1819,"href":"https://pharos.nih.gov/idg/api/v1/targets(3239)/properties"},"_links":{"count":1166,"href":"https://pharos.nih.gov/idg/api/v1/targets(3239)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3239)/synonyms"},"_publications":{"count":1715,"href":"https://pharos.nih.gov/idg/api/v1/targets(3239)/publications"},"_namespace":null},{"id":3240,"version":3,"created":1554876604000,"modified":1555034630000,"deprecated":false,"name":"FYVE and coiled-coil domain-containing protein 1","accession":"Q9BQS8","gene":"FYCO1","description":"May mediate microtubule plus end-directed vesicle transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8800212624932828,"antibodyCount":92,"monoclonalCount":10,"pubmedCount":null,"jensenScore":9.745074,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.63943343554806,"pubTatorScore":0.8535823236282198,"self":"https://pharos.nih.gov/idg/api/v1/targets(3240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(3240)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(3240)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3240)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3240)/publications"},"_namespace":null},{"id":3241,"version":2,"created":1554876608000,"modified":1554876610000,"deprecated":false,"name":"Zinc finger protein with KRAB and SCAN domains 5","accession":"Q9Y2L8","gene":"ZKSCAN5","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.2173272594893338,"antibodyCount":65,"monoclonalCount":6,"pubmedCount":null,"jensenScore":15.854978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.787293686059655,"pubTatorScore":0.4421436487488914,"self":"https://pharos.nih.gov/idg/api/v1/targets(3241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(3241)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(3241)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3241)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3241)/publications"},"_namespace":null},{"id":3242,"version":2,"created":1554876610000,"modified":1554876626000,"deprecated":false,"name":"Acid-sensing ion channel 3","accession":"Q9UHC3","gene":"ASIC3","description":"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.2874470995970055,"antibodyCount":130,"monoclonalCount":1,"pubmedCount":null,"jensenScore":195.840058,"patentCount":7802,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.012662235052375,"pubTatorScore":1.9048913475768912,"self":"https://pharos.nih.gov/idg/api/v1/targets(3242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(3242)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(3242)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3242)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3242)/publications"},"_namespace":null},{"id":3243,"version":2,"created":1554876627000,"modified":1554876627000,"deprecated":false,"name":"Putative BMP-2-inducible kinase-like protein","accession":"Q5H9B9","gene":"BMP2KL","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.326035597651634,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3243)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3243)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3243)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3243)/publications"},"_namespace":null},{"id":3244,"version":3,"created":1554876627000,"modified":1555034631000,"deprecated":false,"name":"DNA mismatch repair protein Mlh3","accession":"Q9UHC1","gene":"MLH3","description":"Probably involved in the repair of mismatches in DNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.783721644523858,"antibodyCount":112,"monoclonalCount":0,"pubmedCount":null,"jensenScore":64.513834,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.500186626500465,"pubTatorScore":1.6083349233563489,"self":"https://pharos.nih.gov/idg/api/v1/targets(3244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(3244)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(3244)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3244)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3244)/publications"},"_namespace":null},{"id":3245,"version":2,"created":1554876631000,"modified":1554876633000,"deprecated":false,"name":"Probable G-protein coupled receptor 22","accession":"Q99680","gene":"GPR22","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.6023320143346045,"antibodyCount":193,"monoclonalCount":18,"pubmedCount":null,"jensenScore":4.918022,"patentCount":5193,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.844039380571783,"pubTatorScore":0.5816842698858917,"self":"https://pharos.nih.gov/idg/api/v1/targets(3245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(3245)/properties"},"_links":{"count":700,"href":"https://pharos.nih.gov/idg/api/v1/targets(3245)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3245)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3245)/publications"},"_namespace":null},{"id":3246,"version":3,"created":1554876633000,"modified":1555034633000,"deprecated":false,"name":"Leucine-rich repeat and calponin homology domain-containing protein 1","accession":"Q9Y2L9","gene":"LRCH1","description":"Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8731267682469749,"antibodyCount":106,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.257539,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":35.87192595074871,"pubTatorScore":1.0755469613925308,"self":"https://pharos.nih.gov/idg/api/v1/targets(3246)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(3246)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(3246)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3246)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3246)/publications"},"_namespace":null},{"id":3247,"version":2,"created":1554876637000,"modified":1554876639000,"deprecated":false,"name":"E3 ubiquitin-protein ligase makorin-1","accession":"Q9UHC7","gene":"MKRN1","description":"E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9609876799605263,"antibodyCount":225,"monoclonalCount":41,"pubmedCount":null,"jensenScore":16.380044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.26180495106231,"pubTatorScore":1.1168217174324815,"self":"https://pharos.nih.gov/idg/api/v1/targets(3247)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3247)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(3247)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3247)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3247)/publications"},"_namespace":null},{"id":3248,"version":2,"created":1554876640000,"modified":1554876641000,"deprecated":false,"name":"Synaptotagmin-15","accession":"Q9BQS2","gene":"SYT15","description":"May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.22617012043132004,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.254762,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.347191272616797,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(3248)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(3248)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3248)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3248)/publications"},"_namespace":null},{"id":3249,"version":2,"created":1554876642000,"modified":1554876646000,"deprecated":false,"name":"Contactin-associated protein-like 2","accession":"Q9UHC6","gene":"CNTNAP2","description":"Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3615556723847035,"antibodyCount":191,"monoclonalCount":53,"pubmedCount":null,"jensenScore":228.44069,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.35113255603199,"pubTatorScore":2.2063855480280736,"self":"https://pharos.nih.gov/idg/api/v1/targets(3249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(3249)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(3249)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3249)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3249)/publications"},"_namespace":null},{"id":3250,"version":2,"created":1554876647000,"modified":1554876649000,"deprecated":false,"name":"FERM domain-containing protein 4B","accession":"Q9Y2L6","gene":"FRMD4B","description":"Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6317818636827021,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.933598,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.864395241443496,"pubTatorScore":0.7894097103020911,"self":"https://pharos.nih.gov/idg/api/v1/targets(3250)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(3250)/properties"},"_links":{"count":904,"href":"https://pharos.nih.gov/idg/api/v1/targets(3250)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3250)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3250)/publications"},"_namespace":null},{"id":3251,"version":2,"created":1554876650000,"modified":1554876652000,"deprecated":false,"name":"Trafficking protein particle complex subunit 8","accession":"Q9Y2L5","gene":"TRAPPC8","description":"May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0837812131857993,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.157495,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.08660320995129,"pubTatorScore":0.5481845695739284,"self":"https://pharos.nih.gov/idg/api/v1/targets(3251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(3251)/properties"},"_links":{"count":1055,"href":"https://pharos.nih.gov/idg/api/v1/targets(3251)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3251)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3251)/publications"},"_namespace":null},{"id":3252,"version":2,"created":1554876653000,"modified":1554876655000,"deprecated":false,"name":"G-protein coupled receptor 20","accession":"Q99678","gene":"GPR20","description":"Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.12264694211447556,"antibodyCount":189,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.501831,"patentCount":1463,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.75393495920914,"pubTatorScore":0.3222192947339193,"self":"https://pharos.nih.gov/idg/api/v1/targets(3252)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(3252)/properties"},"_links":{"count":669,"href":"https://pharos.nih.gov/idg/api/v1/targets(3252)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3252)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3252)/publications"},"_namespace":null},{"id":3253,"version":2,"created":1554876655000,"modified":1554876657000,"deprecated":false,"name":"Stromal membrane-associated protein 2","accession":"Q8WU79","gene":"SMAP2","description":"GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.06694678818296496,"antibodyCount":99,"monoclonalCount":6,"pubmedCount":null,"jensenScore":1.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.34021513702125,"pubTatorScore":0.8295589343341995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3253)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(3253)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(3253)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3253)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3253)/publications"},"_namespace":null},{"id":3254,"version":3,"created":1554876658000,"modified":1555034636000,"deprecated":false,"name":"Probable G-protein coupled receptor 21","accession":"Q99679","gene":"GPR21","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.5720357972853005,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.043552,"patentCount":2018,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":72,"knowledgeAvailability":18.261710756580822,"pubTatorScore":0.3927387982423459,"self":"https://pharos.nih.gov/idg/api/v1/targets(3254)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(3254)/properties"},"_links":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(3254)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3254)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3254)/publications"},"_namespace":null},{"id":3255,"version":3,"created":1554876660000,"modified":1555034637000,"deprecated":false,"name":"Sec1 family domain-containing protein 2","accession":"Q8WU76","gene":"SCFD2","description":"May be involved in protein transport.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.09123287786029066,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.240642,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":28.257219180319513,"pubTatorScore":-0.5890946054160394,"self":"https://pharos.nih.gov/idg/api/v1/targets(3255)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(3255)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(3255)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3255)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3255)/publications"},"_namespace":null},{"id":3256,"version":2,"created":1554876663000,"modified":1554876665000,"deprecated":false,"name":"Zinc finger protein 184","accession":"Q99676","gene":"ZNF184","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.18696719539528905,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.055357,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.906363060484278,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(3256)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(3256)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(3256)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3256)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3256)/publications"},"_namespace":null},{"id":3257,"version":2,"created":1554876666000,"modified":1554876677000,"deprecated":false,"name":"Niemann-Pick C1-like protein 1","accession":"Q9UHC9","gene":"NPC1L1","description":"Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.333122751964074,"antibodyCount":139,"monoclonalCount":4,"pubmedCount":null,"jensenScore":222.746567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.574504417545214,"pubTatorScore":2.2131037714008808,"self":"https://pharos.nih.gov/idg/api/v1/targets(3257)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(3257)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(3257)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3257)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3257)/publications"},"_namespace":null},{"id":3258,"version":3,"created":1554876678000,"modified":1555034640000,"deprecated":false,"name":"Lysophosphatidic acid receptor 4","accession":"Q99677","gene":"LPAR4","description":"Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.3820523782113892,"antibodyCount":190,"monoclonalCount":2,"pubmedCount":null,"jensenScore":22.649822,"patentCount":4871,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":31,"knowledgeAvailability":26.930029238531038,"pubTatorScore":1.2791170904232994,"self":"https://pharos.nih.gov/idg/api/v1/targets(3258)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3258)/properties"},"_links":{"count":742,"href":"https://pharos.nih.gov/idg/api/v1/targets(3258)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3258)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3258)/publications"},"_namespace":null},{"id":3259,"version":2,"created":1554876687000,"modified":1554876689000,"deprecated":false,"name":"Cell growth regulator with EF hand domain protein 1","accession":"Q99674","gene":"CGREF1","description":"Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2761914285552442,"antibodyCount":143,"monoclonalCount":19,"pubmedCount":null,"jensenScore":2.007258,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.678799300183922,"pubTatorScore":-0.12574611624489382,"self":"https://pharos.nih.gov/idg/api/v1/targets(3259)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(3259)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(3259)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3259)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3259)/publications"},"_namespace":null},{"id":3260,"version":3,"created":1554876690000,"modified":1555034641000,"deprecated":false,"name":"Cell growth regulator with RING finger domain protein 1","accession":"Q99675","gene":"CGRRF1","description":"Able to inhibit growth in several cell lines.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.330510403155229,"antibodyCount":111,"monoclonalCount":22,"pubmedCount":null,"jensenScore":2.106957,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":28.033745409234513,"pubTatorScore":0.4760859665580099,"self":"https://pharos.nih.gov/idg/api/v1/targets(3260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(3260)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3260)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3260)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3260)/publications"},"_namespace":null},{"id":3261,"version":2,"created":1554876692000,"modified":1554876694000,"deprecated":false,"name":"Uncharacterized protein KIAA0895-like","accession":"Q68EN5","gene":"KIAA0895L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.68952382801383,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3261)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(3261)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(3261)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3261)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3261)/publications"},"_namespace":null},{"id":3262,"version":3,"created":1554876695000,"modified":1555034646000,"deprecated":false,"name":"TBC1 domain family member 22B","accession":"Q9NU19","gene":"TBC1D22B","description":"May act as a GTPase-activating protein for Rab family protein(s).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.7781512503836436,"antibodyCount":21,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.030303,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":78,"knowledgeAvailability":31.76603601740835,"pubTatorScore":-0.23408345420171428,"self":"https://pharos.nih.gov/idg/api/v1/targets(3262)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(3262)/properties"},"_links":{"count":922,"href":"https://pharos.nih.gov/idg/api/v1/targets(3262)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3262)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3262)/publications"},"_namespace":null},{"id":3263,"version":3,"created":1554876697000,"modified":1555034647000,"deprecated":false,"name":"Uncharacterized protein C14orf37","accession":"Q86TY3","gene":"C14orf37","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(3263)/properties"},"_links":{"count":799,"href":"https://pharos.nih.gov/idg/api/v1/targets(3263)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3263)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3263)/publications"},"_namespace":null},{"id":3264,"version":2,"created":1554876700000,"modified":1554876701000,"deprecated":false,"name":"Proline-rich protein 26","accession":"Q8N8Z3","gene":"PRR26","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.710963431934596,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(3264)/properties"},"_links":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(3264)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3264)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3264)/publications"},"_namespace":null},{"id":3265,"version":2,"created":1554876702000,"modified":1554876706000,"deprecated":false,"name":"Keratin, type I cytoskeletal 18","accession":"P05783","gene":"KRT18","description":"Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.052110655042422,"antibodyCount":1953,"monoclonalCount":1242,"pubmedCount":null,"jensenScore":1057.764141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.97615603097462,"pubTatorScore":2.94043340222893,"self":"https://pharos.nih.gov/idg/api/v1/targets(3265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":611,"href":"https://pharos.nih.gov/idg/api/v1/targets(3265)/properties"},"_links":{"count":1277,"href":"https://pharos.nih.gov/idg/api/v1/targets(3265)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3265)/synonyms"},"_publications":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3265)/publications"},"_namespace":null},{"id":3266,"version":2,"created":1554876707000,"modified":1554876709000,"deprecated":false,"name":"Zinc finger protein 441","accession":"Q8N8Z8","gene":"ZNF441","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.20017196771433,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(3266)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(3266)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3266)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3266)/publications"},"_namespace":null},{"id":3267,"version":2,"created":1554876710000,"modified":1554876712000,"deprecated":false,"name":"Discoidin, CUB and LCCL domain-containing protein 1","accession":"Q8N8Z6","gene":"DCBLD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.028672600643900238,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.564535,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.5974719574861,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3267)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(3267)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(3267)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3267)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3267)/publications"},"_namespace":null},{"id":3268,"version":2,"created":1554876712000,"modified":1554876713000,"deprecated":false,"name":"Putative stereocilin-like protein","accession":"A6NGW2","gene":"STRCP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3053313723832989,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":34.510381,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.97717687504782,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3268)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3268)/properties"},"_links":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3268)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3268)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3268)/publications"},"_namespace":null},{"id":3269,"version":2,"created":1554876713000,"modified":1554876716000,"deprecated":false,"name":"Fanconi-associated nuclease 1","accession":"Q9Y2M0","gene":"FAN1","description":"Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0697031545771214,"antibodyCount":85,"monoclonalCount":1,"pubmedCount":null,"jensenScore":115.918734,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.061351715101324,"pubTatorScore":1.707615791654023,"self":"https://pharos.nih.gov/idg/api/v1/targets(3269)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(3269)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(3269)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(3269)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3269)/publications"},"_namespace":null},{"id":3270,"version":2,"created":1554876717000,"modified":1554876718000,"deprecated":false,"name":"Protein SSUH2 homolog","accession":"Q9Y2M2","gene":"SSUH2","description":"Plays a role in odontogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.729704629998077,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.388889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.08310261832451,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(3270)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(3270)/properties"},"_links":{"count":736,"href":"https://pharos.nih.gov/idg/api/v1/targets(3270)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3270)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3270)/publications"},"_namespace":null},{"id":3271,"version":2,"created":1554876719000,"modified":1554876726000,"deprecated":false,"name":"Protein polybromo-1","accession":"Q86U86","gene":"PBRM1","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.","idgFamily":"TF/Epigenetic","idgTDL":"Tchem","novelty":-1.9250026410094039,"antibodyCount":97,"monoclonalCount":9,"pubmedCount":null,"jensenScore":84.648954,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.090534422478875,"pubTatorScore":2.6050556960059392,"self":"https://pharos.nih.gov/idg/api/v1/targets(3271)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(3271)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(3271)/links"},"_synonyms":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3271)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3271)/publications"},"_namespace":null},{"id":3272,"version":2,"created":1554876727000,"modified":1554876729000,"deprecated":false,"name":"Serine protease 27","accession":"Q9BQR3","gene":"PRSS27","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.206022531942977,"antibodyCount":151,"monoclonalCount":65,"pubmedCount":null,"jensenScore":159.370549,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.136725976437205,"pubTatorScore":1.4615235272592335,"self":"https://pharos.nih.gov/idg/api/v1/targets(3272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3272)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(3272)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3272)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3272)/publications"},"_namespace":null},{"id":3273,"version":2,"created":1554876730000,"modified":1554876731000,"deprecated":false,"name":"Interleukin-19","accession":"Q9UHD0","gene":"IL19","description":"May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9721360681297366,"antibodyCount":249,"monoclonalCount":72,"pubmedCount":null,"jensenScore":102.324026,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.721344415195073,"pubTatorScore":2.002618257395476,"self":"https://pharos.nih.gov/idg/api/v1/targets(3273)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(3273)/properties"},"_links":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(3273)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3273)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3273)/publications"},"_namespace":null},{"id":3274,"version":3,"created":1554876731000,"modified":1555034648000,"deprecated":false,"name":"Cadherin-related family member 5","accession":"Q9HBB8","gene":"CDHR5","description":"Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8507783308668964,"antibodyCount":140,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.904299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":30.123253950753867,"pubTatorScore":1.0414965875533404,"self":"https://pharos.nih.gov/idg/api/v1/targets(3274)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(3274)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(3274)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3274)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3274)/publications"},"_namespace":null},{"id":3275,"version":2,"created":1554876734000,"modified":1554876736000,"deprecated":false,"name":"Junctophilin-2","accession":"Q9BR39","gene":"JPH2","description":"Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2188961966807086,"antibodyCount":229,"monoclonalCount":77,"pubmedCount":null,"jensenScore":163.002708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.915606369057286,"pubTatorScore":1.3203141531576856,"self":"https://pharos.nih.gov/idg/api/v1/targets(3275)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(3275)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(3275)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3275)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3275)/publications"},"_namespace":null},{"id":3276,"version":2,"created":1554876737000,"modified":1554876739000,"deprecated":false,"name":"Uncharacterized aarF domain-containing protein kinase 1","accession":"Q86TW2","gene":"ADCK1","description":"The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).","idgFamily":"Kinase","idgTDL":"Tdark","novelty":-0.04092795043405109,"antibodyCount":142,"monoclonalCount":21,"pubmedCount":null,"jensenScore":1.085714,"patentCount":1673,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.346294517281013,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3276)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3276)/publications"},"_namespace":null},{"id":3277,"version":3,"created":1554876739000,"modified":1555034649000,"deprecated":false,"name":"Cell death activator CIDE-B","accession":"Q9UHD4","gene":"CIDEB","description":"Activates apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.292161665997601,"antibodyCount":249,"monoclonalCount":27,"pubmedCount":null,"jensenScore":23.591574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.41911227198315,"pubTatorScore":1.2581698894143782,"self":"https://pharos.nih.gov/idg/api/v1/targets(3277)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3277)/publications"},"_namespace":null},{"id":3278,"version":2,"created":1554876742000,"modified":1554876765000,"deprecated":false,"name":"Scavenger receptor class B member 1","accession":"Q8WTV0","gene":"SCARB1","description":"(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.939203982426617,"antibodyCount":378,"monoclonalCount":81,"pubmedCount":null,"jensenScore":915.723341,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.673156794159,"pubTatorScore":2.727438818953321,"self":"https://pharos.nih.gov/idg/api/v1/targets(3278)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":696,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/properties"},"_links":{"count":1299,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/synonyms"},"_publications":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(3278)/publications"},"_namespace":null},{"id":3279,"version":3,"created":1554876767000,"modified":1555034652000,"deprecated":false,"name":"THAP domain-containing protein 3","accession":"Q8WTV1","gene":"THAP3","description":"Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.5440680443502757,"antibodyCount":28,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.233108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":29.195064730783304,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3279)/publications"},"_namespace":null},{"id":3280,"version":3,"created":1554876770000,"modified":1555034653000,"deprecated":false,"name":"Serine/threonine-protein kinase TBK1","accession":"Q9UHD2","gene":"TBK1","description":"Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.7672782675143526,"antibodyCount":455,"monoclonalCount":105,"pubmedCount":null,"jensenScore":569.148945,"patentCount":19375,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.73110335667031,"pubTatorScore":2.53150513486421,"self":"https://pharos.nih.gov/idg/api/v1/targets(3280)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/properties"},"_links":{"count":1306,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/synonyms"},"_publications":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(3280)/publications"},"_namespace":null},{"id":3281,"version":3,"created":1554876806000,"modified":1555034655000,"deprecated":false,"name":"Cysteine and histidine-rich domain-containing protein 1","accession":"Q9UHD1","gene":"CHORDC1","description":"Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5378190987647773,"antibodyCount":157,"monoclonalCount":4,"pubmedCount":null,"jensenScore":2.152274,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.38127909753965,"pubTatorScore":0.693873388727159,"self":"https://pharos.nih.gov/idg/api/v1/targets(3281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3281)/publications"},"_namespace":null},{"id":3282,"version":3,"created":1554876809000,"modified":1555034657000,"deprecated":false,"name":"Kelch-like protein 20","accession":"Q9Y2M5","gene":"KLHL20","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7042458748373711,"antibodyCount":76,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.773843,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":36.26817780826337,"pubTatorScore":0.8494584186925345,"self":"https://pharos.nih.gov/idg/api/v1/targets(3282)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3282)/publications"},"_namespace":null},{"id":3283,"version":2,"created":1554876813000,"modified":1554876816000,"deprecated":false,"name":"Septin-9","accession":"Q9UHD8","gene":"SEPT9","description":"Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2089763892385057,"antibodyCount":130,"monoclonalCount":4,"pubmedCount":null,"jensenScore":161.903261,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.708296308402524,"pubTatorScore":2.1319263527215027,"self":"https://pharos.nih.gov/idg/api/v1/targets(3283)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":498,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/properties"},"_links":{"count":1430,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/links"},"_synonyms":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3283)/publications"},"_namespace":null},{"id":3284,"version":2,"created":1554876818000,"modified":1554876820000,"deprecated":false,"name":"Midasin","accession":"Q9NU22","gene":"MDN1","description":"Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.2317547170344818,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.266918,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.842612720853225,"pubTatorScore":1.0600679589174657,"self":"https://pharos.nih.gov/idg/api/v1/targets(3284)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3284)/publications"},"_namespace":null},{"id":3285,"version":3,"created":1554876821000,"modified":1555034658000,"deprecated":false,"name":"LYR motif-containing protein 2","accession":"Q9NU23","gene":"LYRM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":95,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.309528651376876,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3285)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/properties"},"_links":{"count":734,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3285)/publications"},"_namespace":null},{"id":3286,"version":2,"created":1554876823000,"modified":1554876825000,"deprecated":false,"name":"Phospholipase ABHD3","accession":"Q8WU67","gene":"ABHD3","description":"Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4121804524915048,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.225491,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.366070812284867,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3286)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3286)/publications"},"_namespace":null},{"id":3287,"version":2,"created":1554876826000,"modified":1554876828000,"deprecated":false,"name":"Splicing factor U2AF 26 kDa subunit","accession":"Q8WU68","gene":"U2AF1L4","description":"RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.17609125688420882,"antibodyCount":61,"monoclonalCount":8,"pubmedCount":null,"jensenScore":1.858334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.975073729738632,"pubTatorScore":0.728450290201975,"self":"https://pharos.nih.gov/idg/api/v1/targets(3287)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3287)/publications"},"_namespace":null},{"id":3288,"version":3,"created":1554876829000,"modified":1555034660000,"deprecated":false,"name":"Interleukin-12 receptor subunit beta-2","accession":"Q99665","gene":"IL12RB2","description":"Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5400866713045835,"antibodyCount":214,"monoclonalCount":38,"pubmedCount":null,"jensenScore":32.618165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.55509868625663,"pubTatorScore":1.6702607376128342,"self":"https://pharos.nih.gov/idg/api/v1/targets(3288)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(3288)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(3288)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3288)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3288)/publications"},"_namespace":null},{"id":3289,"version":2,"created":1554876832000,"modified":1554876834000,"deprecated":false,"name":"Thrombospondin-type laminin G domain and EAR repeat-containing protein","accession":"Q8WU66","gene":"TSPEAR","description":"May play a role in development or function of the auditory system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5070844796481574,"antibodyCount":75,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.321795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.667883093733128,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3289)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(3289)/properties"},"_links":{"count":733,"href":"https://pharos.nih.gov/idg/api/v1/targets(3289)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3289)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3289)/publications"},"_namespace":null},{"id":3290,"version":2,"created":1554876834000,"modified":1554876838000,"deprecated":false,"name":"RANBP2-like and GRIP domain-containing protein 5/6","accession":"Q99666","gene":"RGPD5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5885400360486637,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.990249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.42873230445839,"pubTatorScore":0.6797306160859238,"self":"https://pharos.nih.gov/idg/api/v1/targets(3290)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(3290)/properties"},"_links":{"count":1582,"href":"https://pharos.nih.gov/idg/api/v1/targets(3290)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3290)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3290)/publications"},"_namespace":null},{"id":3291,"version":3,"created":1554876839000,"modified":1555034662000,"deprecated":false,"name":"Ubiquilin-2","accession":"Q9UHD9","gene":"UBQLN2","description":"Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9084786521682129,"antibodyCount":168,"monoclonalCount":29,"pubmedCount":null,"jensenScore":82.071101,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.40908344694056,"pubTatorScore":1.7691502222791438,"self":"https://pharos.nih.gov/idg/api/v1/targets(3291)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(3291)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3291)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3291)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3291)/publications"},"_namespace":null},{"id":3292,"version":2,"created":1554876843000,"modified":1554876843000,"deprecated":false,"name":"Putative oocyte-secreted protein 1 homolog","accession":"A8MZH6","gene":"OOSP1","description":"May be involved in cell differentiation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.13356118135797412,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.367894,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.250086391566859,"pubTatorScore":-0.018483556752989648,"self":"https://pharos.nih.gov/idg/api/v1/targets(3292)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3292)/properties"},"_links":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3292)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3292)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3292)/publications"},"_namespace":null},{"id":3293,"version":3,"created":1554876843000,"modified":1555034664000,"deprecated":false,"name":"Gap junction beta-4 protein","accession":"Q9NTQ9","gene":"GJB4","description":"One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6010010836162576,"antibodyCount":125,"monoclonalCount":19,"pubmedCount":null,"jensenScore":40.215998,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":23.583306117243616,"pubTatorScore":1.3864978597481006,"self":"https://pharos.nih.gov/idg/api/v1/targets(3293)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(3293)/properties"},"_links":{"count":660,"href":"https://pharos.nih.gov/idg/api/v1/targets(3293)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3293)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3293)/publications"},"_namespace":null},{"id":3294,"version":2,"created":1554876846000,"modified":1554876849000,"deprecated":false,"name":"Kinesin-like protein KIF2C","accession":"Q99661","gene":"KIF2C","description":"In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.124036920108818,"antibodyCount":256,"monoclonalCount":39,"pubmedCount":null,"jensenScore":136.327026,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.98226049932477,"pubTatorScore":2.101955694770673,"self":"https://pharos.nih.gov/idg/api/v1/targets(3294)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(3294)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(3294)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3294)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3294)/publications"},"_namespace":null},{"id":3295,"version":2,"created":1554876850000,"modified":1554876852000,"deprecated":false,"name":"Scavenger receptor cysteine-rich domain-containing group B protein","accession":"Q8WTU2","gene":"SSC4D","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2466723327623292,"antibodyCount":80,"monoclonalCount":23,"pubmedCount":null,"jensenScore":0.895605,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.39408108095918,"pubTatorScore":0.19497669561912645,"self":"https://pharos.nih.gov/idg/api/v1/targets(3295)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(3295)/properties"},"_links":{"count":691,"href":"https://pharos.nih.gov/idg/api/v1/targets(3295)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3295)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3295)/publications"},"_namespace":null},{"id":3296,"version":3,"created":1554876852000,"modified":1555034666000,"deprecated":false,"name":"V-type proton ATPase subunit d 2","accession":"Q8N8Y2","gene":"ATP6V0D2","description":"Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1706478462416416,"antibodyCount":74,"monoclonalCount":22,"pubmedCount":null,"jensenScore":11.999769,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":21.663206606352237,"pubTatorScore":0.7945502236973013,"self":"https://pharos.nih.gov/idg/api/v1/targets(3296)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(3296)/properties"},"_links":{"count":609,"href":"https://pharos.nih.gov/idg/api/v1/targets(3296)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3296)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3296)/publications"},"_namespace":null},{"id":3297,"version":2,"created":1554876854000,"modified":1554876857000,"deprecated":false,"name":"Acyl-coenzyme A thioesterase 1","accession":"Q86TX2","gene":"ACOT1","description":"Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-2.1431086570898166,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":129.560743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.36816306980847,"pubTatorScore":1.787578525642795,"self":"https://pharos.nih.gov/idg/api/v1/targets(3297)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3297)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(3297)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3297)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3297)/publications"},"_namespace":null},{"id":3298,"version":2,"created":1554876857000,"modified":1554876859000,"deprecated":false,"name":"YrdC domain-containing protein, mitochondrial","accession":"Q86U90","gene":"YRDC","description":"May regulate the activity of some transporters.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.793673985049292,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":58.523766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.48506213887394,"pubTatorScore":1.2075317723841736,"self":"https://pharos.nih.gov/idg/api/v1/targets(3298)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(3298)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(3298)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3298)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3298)/publications"},"_namespace":null},{"id":3299,"version":3,"created":1554876860000,"modified":1555034669000,"deprecated":false,"name":"Zinc finger protein 41 homolog","accession":"Q8N8Y5","gene":"ZFP41","description":"A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":34,"knowledgeAvailability":25.241231619128072,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3299)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(3299)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(3299)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3299)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3299)/publications"},"_namespace":null},{"id":3300,"version":2,"created":1554876862000,"modified":1554876864000,"deprecated":false,"name":"Uncharacterized protein C12orf29","accession":"Q8N999","gene":"C12orf29","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.13365396717624062,"antibodyCount":87,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.016667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-1.568202158361694,"self":"https://pharos.nih.gov/idg/api/v1/targets(3300)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(3300)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(3300)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3300)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3300)/publications"},"_namespace":null},{"id":3301,"version":2,"created":1554876865000,"modified":1554876866000,"deprecated":false,"name":"Protein mab-21-like 3","accession":"Q8N8X9","gene":"MAB21L3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3640817438539767,"antibodyCount":31,"monoclonalCount":15,"pubmedCount":null,"jensenScore":2.246324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.03759334862434,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3301)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3301)/properties"},"_links":{"count":664,"href":"https://pharos.nih.gov/idg/api/v1/targets(3301)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3301)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3301)/publications"},"_namespace":null},{"id":3302,"version":2,"created":1554876867000,"modified":1554876869000,"deprecated":false,"name":"Tetratricopeptide repeat protein 7B","accession":"Q86TV6","gene":"TTC7B","description":"Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3862016097437383,"antibodyCount":21,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.174242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.47477307646252,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(3302)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(3302)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(3302)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3302)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3302)/publications"},"_namespace":null},{"id":3303,"version":3,"created":1554876870000,"modified":1555034671000,"deprecated":false,"name":"Golgi reassembly-stacking protein 1","accession":"Q9BQQ3","gene":"GORASP1","description":"Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5175919609314736,"antibodyCount":157,"monoclonalCount":29,"pubmedCount":null,"jensenScore":35.045299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":32.472535797903866,"pubTatorScore":1.689910539484689,"self":"https://pharos.nih.gov/idg/api/v1/targets(3303)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(3303)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(3303)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3303)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3303)/publications"},"_namespace":null},{"id":3304,"version":2,"created":1554876873000,"modified":1554876876000,"deprecated":false,"name":"Argininosuccinate lyase","accession":"P04424","gene":"ASL","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1347639203922864,"antibodyCount":199,"monoclonalCount":31,"pubmedCount":null,"jensenScore":130.773401,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.012501174390636,"pubTatorScore":2.363935643651663,"self":"https://pharos.nih.gov/idg/api/v1/targets(3304)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(3304)/properties"},"_links":{"count":1070,"href":"https://pharos.nih.gov/idg/api/v1/targets(3304)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3304)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3304)/publications"},"_namespace":null},{"id":3305,"version":3,"created":1554876877000,"modified":1555034672000,"deprecated":false,"name":"Coiled-coil domain-containing protein 89","accession":"Q8N998","gene":"CCDC89","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":19.19066239714528,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3305)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3305)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(3305)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3305)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3305)/publications"},"_namespace":null},{"id":3306,"version":2,"created":1554876880000,"modified":1554876881000,"deprecated":false,"name":"Receptor-transporting protein 3","accession":"Q9BQQ7","gene":"RTP3","description":"Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8779469553206913,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.794552,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.108421867444326,"pubTatorScore":0.8461308041888891,"self":"https://pharos.nih.gov/idg/api/v1/targets(3306)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3306)/properties"},"_links":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(3306)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3306)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3306)/publications"},"_namespace":null},{"id":3307,"version":2,"created":1554876881000,"modified":1554876882000,"deprecated":false,"name":"Osteoclast stimulatory transmembrane protein","accession":"Q9BR26","gene":"OCSTAMP","description":"Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8649237628451083,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.139828,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.447405965041114,"pubTatorScore":0.40559306772467546,"self":"https://pharos.nih.gov/idg/api/v1/targets(3307)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3307)/properties"},"_links":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(3307)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3307)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3307)/publications"},"_namespace":null},{"id":3308,"version":2,"created":1554876882000,"modified":1554876883000,"deprecated":false,"name":"Putative N-acetylated-alpha-linked acidic dipeptidase","accession":"Q9HBA9","gene":"FOLH1B","description":"Exhibits a dipeptidyl-peptidase IV type activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0883098412461387,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2218.968205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.586050094771787,"pubTatorScore":0.3679767232525211,"self":"https://pharos.nih.gov/idg/api/v1/targets(3308)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3308)/properties"},"_links":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(3308)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3308)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3308)/publications"},"_namespace":null},{"id":3309,"version":2,"created":1554876883000,"modified":1554876885000,"deprecated":false,"name":"N-acetyltransferase 8","accession":"Q9UHE5","gene":"NAT8","description":"Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7441813512170123,"antibodyCount":143,"monoclonalCount":27,"pubmedCount":null,"jensenScore":54.481855,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.524290073845208,"pubTatorScore":1.5242296041415224,"self":"https://pharos.nih.gov/idg/api/v1/targets(3309)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(3309)/properties"},"_links":{"count":768,"href":"https://pharos.nih.gov/idg/api/v1/targets(3309)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3309)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3309)/publications"},"_namespace":null},{"id":3310,"version":3,"created":1554876886000,"modified":1555034673000,"deprecated":false,"name":"Protein DDI1 homolog 1","accession":"Q8WTU0","gene":"DDI1","description":"Probable aspartic protease.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3756636465329728,"antibodyCount":44,"monoclonalCount":3,"pubmedCount":null,"jensenScore":25.390153,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":15.848461841415821,"pubTatorScore":0.6351485472338603,"self":"https://pharos.nih.gov/idg/api/v1/targets(3310)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3310)/properties"},"_links":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(3310)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3310)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3310)/publications"},"_namespace":null},{"id":3311,"version":2,"created":1554876887000,"modified":1554876888000,"deprecated":false,"name":"Uncharacterized protein C16orf90","accession":"A8MZG2","gene":"C16orf90","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.5797835966168101,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.026316,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3311)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3311)/properties"},"_links":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(3311)/links"},"_synonyms":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3311)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3311)/publications"},"_namespace":null},{"id":3312,"version":2,"created":1554876888000,"modified":1554876910000,"deprecated":false,"name":"Transient receptor potential cation channel subfamily V member 4","accession":"Q9HBA0","gene":"TRPV4","description":"Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:18826956, PubMed:18695040). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260).","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.8601586799783605,"antibodyCount":258,"monoclonalCount":2,"pubmedCount":null,"jensenScore":747.329295,"patentCount":81382,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.17073060983234,"pubTatorScore":2.531234203642114,"self":"https://pharos.nih.gov/idg/api/v1/targets(3312)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":529,"href":"https://pharos.nih.gov/idg/api/v1/targets(3312)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3312)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3312)/synonyms"},"_publications":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(3312)/publications"},"_namespace":null},{"id":3313,"version":2,"created":1554876912000,"modified":1554876914000,"deprecated":false,"name":"Metalloreductase STEAP1","accession":"Q9UHE8","gene":"STEAP1","description":"Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6545415755705275,"antibodyCount":322,"monoclonalCount":71,"pubmedCount":null,"jensenScore":46.191664,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.273453731449955,"pubTatorScore":1.5511933346216429,"self":"https://pharos.nih.gov/idg/api/v1/targets(3313)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(3313)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(3313)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3313)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3313)/publications"},"_namespace":null},{"id":3314,"version":2,"created":1554876915000,"modified":1554876918000,"deprecated":false,"name":"Histone H1.2","accession":"P16403","gene":"HIST1H1C","description":"Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0171808159983375,"antibodyCount":142,"monoclonalCount":5,"pubmedCount":null,"jensenScore":95.277021,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.04949015114816,"pubTatorScore":1.8594544963093418,"self":"https://pharos.nih.gov/idg/api/v1/targets(3314)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":453,"href":"https://pharos.nih.gov/idg/api/v1/targets(3314)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(3314)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3314)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3314)/publications"},"_namespace":null},{"id":3315,"version":2,"created":1554876919000,"modified":1554876921000,"deprecated":false,"name":"Histone H1.3","accession":"P16402","gene":"HIST1H1D","description":"Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8321237601062543,"antibodyCount":66,"monoclonalCount":2,"pubmedCount":null,"jensenScore":63.761298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.748107618252796,"pubTatorScore":1.5636227301025343,"self":"https://pharos.nih.gov/idg/api/v1/targets(3315)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(3315)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(3315)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3315)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(3315)/publications"},"_namespace":null},{"id":3316,"version":2,"created":1554876922000,"modified":1554876924000,"deprecated":false,"name":"Histone H1.5","accession":"P16401","gene":"HIST1H1B","description":"Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1322367976036487,"antibodyCount":103,"monoclonalCount":27,"pubmedCount":null,"jensenScore":134.141428,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.460865784905984,"pubTatorScore":2.992182908319609,"self":"https://pharos.nih.gov/idg/api/v1/targets(3316)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3316)/properties"},"_links":{"count":611,"href":"https://pharos.nih.gov/idg/api/v1/targets(3316)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3316)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3316)/publications"},"_namespace":null},{"id":3317,"version":3,"created":1554876924000,"modified":1555034674000,"deprecated":false,"name":"Hypoxia-inducible factor 3-alpha","accession":"Q9Y2N7","gene":"HIF3A","description":"Isoform 5: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.542333033850539,"antibodyCount":249,"monoclonalCount":60,"pubmedCount":null,"jensenScore":341.783319,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.87371867867744,"pubTatorScore":2.047670899651882,"self":"https://pharos.nih.gov/idg/api/v1/targets(3317)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(3317)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3317)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3317)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(3317)/publications"},"_namespace":null},{"id":3318,"version":3,"created":1554876928000,"modified":1555034678000,"deprecated":false,"name":"Cytotoxic T-lymphocyte protein 4","accession":"P16410","gene":"CTLA4","description":"Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.585645126657133,"antibodyCount":887,"monoclonalCount":591,"pubmedCount":null,"jensenScore":3949.074574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":96,"knowledgeAvailability":42.431027022890056,"pubTatorScore":3.3998728794210917,"self":"https://pharos.nih.gov/idg/api/v1/targets(3318)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3318)/properties"},"_links":{"count":1655,"href":"https://pharos.nih.gov/idg/api/v1/targets(3318)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(3318)/synonyms"},"_publications":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(3318)/publications"},"_namespace":null},{"id":3319,"version":3,"created":1554876939000,"modified":1555034684000,"deprecated":false,"name":"Tyrosine aminotransferase","accession":"P17735","gene":"TAT","description":"Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.067409559722678,"antibodyCount":162,"monoclonalCount":13,"pubmedCount":null,"jensenScore":1138.692802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.77783630818001,"pubTatorScore":2.3335248339759382,"self":"https://pharos.nih.gov/idg/api/v1/targets(3319)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(3319)/properties"},"_links":{"count":768,"href":"https://pharos.nih.gov/idg/api/v1/targets(3319)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3319)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3319)/publications"},"_namespace":null},{"id":3320,"version":2,"created":1554876942000,"modified":1554876944000,"deprecated":false,"name":"Nucleolar complex protein 3 homolog","accession":"Q8WTT2","gene":"NOC3L","description":"May be required for adipogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.130563505885426,"antibodyCount":168,"monoclonalCount":6,"pubmedCount":null,"jensenScore":15.572261,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.78193688408699,"pubTatorScore":0.7755584606098896,"self":"https://pharos.nih.gov/idg/api/v1/targets(3320)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3320)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(3320)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3320)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3320)/publications"},"_namespace":null},{"id":3321,"version":2,"created":1554876945000,"modified":1554876947000,"deprecated":false,"name":"Forkhead box protein D4-like 1","accession":"Q9NU39","gene":"FOXD4L1","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.5807472874368124,"antibodyCount":101,"monoclonalCount":5,"pubmedCount":null,"jensenScore":4.939596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.450333266792398,"pubTatorScore":0.40889921907962035,"self":"https://pharos.nih.gov/idg/api/v1/targets(3321)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3321)/properties"},"_links":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(3321)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3321)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3321)/publications"},"_namespace":null},{"id":3322,"version":2,"created":1554876947000,"modified":1554876950000,"deprecated":false,"name":"Calcineurin B homologous protein 1","accession":"Q99653","gene":"CHP1","description":"Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6396592095187927,"antibodyCount":162,"monoclonalCount":34,"pubmedCount":null,"jensenScore":41.881762,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.318135276957094,"pubTatorScore":2.714279486830124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3322)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(3322)/properties"},"_links":{"count":1079,"href":"https://pharos.nih.gov/idg/api/v1/targets(3322)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3322)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3322)/publications"},"_namespace":null},{"id":3323,"version":3,"created":1554876951000,"modified":1555034686000,"deprecated":false,"name":"C-type lectin domain family 4 member C","accession":"Q8WTT0","gene":"CLEC4C","description":"Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9532672678246208,"antibodyCount":140,"monoclonalCount":47,"pubmedCount":null,"jensenScore":82.382435,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":15.903560952779905,"pubTatorScore":1.8290721388184488,"self":"https://pharos.nih.gov/idg/api/v1/targets(3323)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(3323)/properties"},"_links":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(3323)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3323)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3323)/publications"},"_namespace":null},{"id":3324,"version":3,"created":1554876953000,"modified":1555034687000,"deprecated":false,"name":"Oncostatin-M-specific receptor subunit beta","accession":"Q99650","gene":"OSMR","description":"Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.268773969773528,"antibodyCount":258,"monoclonalCount":88,"pubmedCount":null,"jensenScore":178.800186,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.106904790652926,"pubTatorScore":1.6620483327960054,"self":"https://pharos.nih.gov/idg/api/v1/targets(3324)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(3324)/properties"},"_links":{"count":1046,"href":"https://pharos.nih.gov/idg/api/v1/targets(3324)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3324)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3324)/publications"},"_namespace":null},{"id":3325,"version":2,"created":1554876957000,"modified":1554876958000,"deprecated":false,"name":"BPI fold-containing family A member 3","accession":"Q9BQP9","gene":"BPIFA3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":16,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.559987184064433,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3325)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3325)/properties"},"_links":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3325)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3325)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3325)/publications"},"_namespace":null},{"id":3326,"version":2,"created":1554876958000,"modified":1554876959000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-16","accession":"P04430","gene":"IGKV1-16","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.2653879042642236,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3326)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(3326)/properties"},"_links":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(3326)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3326)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3326)/publications"},"_namespace":null},{"id":3327,"version":2,"created":1554876959000,"modified":1554876961000,"deprecated":false,"name":"Protein FAM222B","accession":"Q8WU58","gene":"FAM222B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.164505449504343,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(3327)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(3327)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3327)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3327)/publications"},"_namespace":null},{"id":3328,"version":3,"created":1554876962000,"modified":1555034688000,"deprecated":false,"name":"Apoptosis-inducing factor 3","accession":"Q96NN9","gene":"AIFM3","description":"Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5929166100785324,"antibodyCount":149,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.029701,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.76283033812647,"pubTatorScore":0.46311055451601085,"self":"https://pharos.nih.gov/idg/api/v1/targets(3328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(3328)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(3328)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3328)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3328)/publications"},"_namespace":null},{"id":3329,"version":3,"created":1554876964000,"modified":1555034690000,"deprecated":false,"name":"ATPase family AAA domain-containing protein 2","accession":"Q6PL18","gene":"ATAD2","description":"May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.3226221159047116,"antibodyCount":119,"monoclonalCount":10,"pubmedCount":null,"jensenScore":209.300296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.4707244733146,"pubTatorScore":1.865088291172495,"self":"https://pharos.nih.gov/idg/api/v1/targets(3329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3329)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(3329)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(3329)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3329)/publications"},"_namespace":null},{"id":3330,"version":2,"created":1554876975000,"modified":1554876975000,"deprecated":false,"name":"Immunoglobulin kappa variable 1D-39","accession":"P04432","gene":"IGKV1D-39","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.2653879042642236,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(3330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3330)/properties"},"_links":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3330)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3330)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3330)/publications"},"_namespace":null},{"id":3331,"version":3,"created":1554876975000,"modified":1555034692000,"deprecated":false,"name":"Protein SREK1IP1","accession":"Q8N9Q2","gene":"SREK1IP1","description":"Possible splicing regulator involved in the control of cellular survival.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2394339243967885,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.754062,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":28.65791639534121,"pubTatorScore":0.09123279782898255,"self":"https://pharos.nih.gov/idg/api/v1/targets(3331)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3331)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(3331)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3331)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3331)/publications"},"_namespace":null},{"id":3332,"version":3,"created":1554876978000,"modified":1555034694000,"deprecated":false,"name":"Interleukin-18 receptor 1","accession":"Q13478","gene":"IL18R1","description":"Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4975889956444015,"antibodyCount":503,"monoclonalCount":262,"pubmedCount":null,"jensenScore":28.804878,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.07257024859315,"pubTatorScore":2.2415447075558244,"self":"https://pharos.nih.gov/idg/api/v1/targets(3332)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(3332)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(3332)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3332)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3332)/publications"},"_namespace":null},{"id":3333,"version":3,"created":1554876982000,"modified":1555034695000,"deprecated":false,"name":"Mucosal addressin cell adhesion molecule 1","accession":"Q13477","gene":"MADCAM1","description":"Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.387463019812275,"antibodyCount":538,"monoclonalCount":432,"pubmedCount":null,"jensenScore":252.285583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.88723143350248,"pubTatorScore":1.9683041411975621,"self":"https://pharos.nih.gov/idg/api/v1/targets(3333)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3333)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(3333)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3333)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3333)/publications"},"_namespace":null},{"id":3334,"version":3,"created":1554876985000,"modified":1555034696000,"deprecated":false,"name":"NADPH oxidase 3","accession":"Q9HBY0","gene":"NOX3","description":"NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5292231449297065,"antibodyCount":139,"monoclonalCount":0,"pubmedCount":null,"jensenScore":32.882134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.627951109780753,"pubTatorScore":1.2612096317348012,"self":"https://pharos.nih.gov/idg/api/v1/targets(3334)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(3334)/properties"},"_links":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(3334)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3334)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3334)/publications"},"_namespace":null},{"id":3335,"version":3,"created":1554876986000,"modified":1555034697000,"deprecated":false,"name":"Sodium-dependent phosphate transporter 1","accession":"Q8WUM9","gene":"SLC20A1","description":"(Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.7930775648743094,"antibodyCount":101,"monoclonalCount":27,"pubmedCount":null,"jensenScore":59.577648,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":41.53319354852115,"pubTatorScore":1.6228396816832604,"self":"https://pharos.nih.gov/idg/api/v1/targets(3335)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(3335)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(3335)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3335)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3335)/publications"},"_namespace":null},{"id":3336,"version":2,"created":1554876990000,"modified":1554876992000,"deprecated":false,"name":"tRNA-splicing ligase RtcB homolog","accession":"Q9Y3I0","gene":"RTCB","description":"Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7565092802057947,"antibodyCount":144,"monoclonalCount":3,"pubmedCount":null,"jensenScore":56.620049,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.43908618924307,"pubTatorScore":1.516897201298697,"self":"https://pharos.nih.gov/idg/api/v1/targets(3336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(3336)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(3336)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3336)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3336)/publications"},"_namespace":null},{"id":3337,"version":3,"created":1554876993000,"modified":1555034699000,"deprecated":false,"name":"F-box only protein 7","accession":"Q9Y3I1","gene":"FBXO7","description":"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0723119892253874,"antibodyCount":100,"monoclonalCount":22,"pubmedCount":null,"jensenScore":118.623035,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":42.207293272911265,"pubTatorScore":1.5683740108967508,"self":"https://pharos.nih.gov/idg/api/v1/targets(3337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(3337)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3337)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(3337)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3337)/publications"},"_namespace":null},{"id":3338,"version":3,"created":1554876997000,"modified":1555034702000,"deprecated":false,"name":"Zinc transporter ZIP9","accession":"Q9NUM3","gene":"SLC39A9","description":"May act as a zinc-influx transporter.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.9573877138632524,"antibodyCount":98,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.403264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":42,"knowledgeAvailability":32.39958511226408,"pubTatorScore":0.9337476346359079,"self":"https://pharos.nih.gov/idg/api/v1/targets(3338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(3338)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(3338)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3338)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3338)/publications"},"_namespace":null},{"id":3339,"version":2,"created":1554877000000,"modified":1554877003000,"deprecated":false,"name":"Transmembrane protein 106B","accession":"Q9NUM4","gene":"TMEM106B","description":"Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5401662038112933,"antibodyCount":87,"monoclonalCount":4,"pubmedCount":null,"jensenScore":36.221008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.813112240864285,"pubTatorScore":1.475515162884884,"self":"https://pharos.nih.gov/idg/api/v1/targets(3339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3339)/properties"},"_links":{"count":1046,"href":"https://pharos.nih.gov/idg/api/v1/targets(3339)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3339)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3339)/publications"},"_namespace":null},{"id":3340,"version":2,"created":1554877004000,"modified":1554877006000,"deprecated":false,"name":"Zinc transporter 2","accession":"Q9BRI3","gene":"SLC30A2","description":null,"idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.5949760220077644,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.40505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.17951623812036,"pubTatorScore":1.4085427801185857,"self":"https://pharos.nih.gov/idg/api/v1/targets(3340)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(3340)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(3340)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3340)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3340)/publications"},"_namespace":null},{"id":3341,"version":2,"created":1554877007000,"modified":1554877010000,"deprecated":false,"name":"GRB2-associated-binding protein 1","accession":"Q13480","gene":"GAB1","description":"Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5556261710312684,"antibodyCount":268,"monoclonalCount":37,"pubmedCount":null,"jensenScore":50.417416,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.43894446450776,"pubTatorScore":2.061205682964476,"self":"https://pharos.nih.gov/idg/api/v1/targets(3341)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":566,"href":"https://pharos.nih.gov/idg/api/v1/targets(3341)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(3341)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3341)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3341)/publications"},"_namespace":null},{"id":3342,"version":2,"created":1554877011000,"modified":1554877014000,"deprecated":false,"name":"Programmed cell death 6-interacting protein","accession":"Q8WUM4","gene":"PDCD6IP","description":"(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5940351723428419,"antibodyCount":216,"monoclonalCount":72,"pubmedCount":null,"jensenScore":35.130813,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.41925697631756,"pubTatorScore":2.1888581279782033,"self":"https://pharos.nih.gov/idg/api/v1/targets(3342)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":551,"href":"https://pharos.nih.gov/idg/api/v1/targets(3342)/properties"},"_links":{"count":1288,"href":"https://pharos.nih.gov/idg/api/v1/targets(3342)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(3342)/synonyms"},"_publications":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(3342)/publications"},"_namespace":null},{"id":3343,"version":3,"created":1554877015000,"modified":1555034703000,"deprecated":false,"name":"G-protein coupled receptor 35","accession":"Q9HC97","gene":"GPR35","description":"Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.767303681646617,"antibodyCount":161,"monoclonalCount":0,"pubmedCount":null,"jensenScore":64.153793,"patentCount":7596,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":31.073936769119573,"pubTatorScore":1.5921947730234647,"self":"https://pharos.nih.gov/idg/api/v1/targets(3343)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(3343)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(3343)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3343)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3343)/publications"},"_namespace":null},{"id":3344,"version":2,"created":1554877031000,"modified":1554877034000,"deprecated":false,"name":"Calpain-10","accession":"Q9HC96","gene":"CAPN10","description":"Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.270960817358929,"antibodyCount":112,"monoclonalCount":3,"pubmedCount":null,"jensenScore":197.771824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.75200898865579,"pubTatorScore":2.427527136301319,"self":"https://pharos.nih.gov/idg/api/v1/targets(3344)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(3344)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(3344)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3344)/synonyms"},"_publications":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(3344)/publications"},"_namespace":null},{"id":3345,"version":3,"created":1554877035000,"modified":1555034707000,"deprecated":false,"name":"Mothers against decapentaplegic homolog 4","accession":"Q13485","gene":"SMAD4","description":"In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.1612894020468527,"antibodyCount":605,"monoclonalCount":274,"pubmedCount":null,"jensenScore":1349.751405,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":60.70303734270319,"pubTatorScore":2.9769698016465025,"self":"https://pharos.nih.gov/idg/api/v1/targets(3345)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1138,"href":"https://pharos.nih.gov/idg/api/v1/targets(3345)/properties"},"_links":{"count":1634,"href":"https://pharos.nih.gov/idg/api/v1/targets(3345)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3345)/synonyms"},"_publications":{"count":554,"href":"https://pharos.nih.gov/idg/api/v1/targets(3345)/publications"},"_namespace":null},{"id":3346,"version":3,"created":1554877044000,"modified":1555034710000,"deprecated":false,"name":"Nuclear pore complex protein Nup133","accession":"Q8WUM0","gene":"NUP133","description":"Involved in poly(A)+ RNA transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3647879732828272,"antibodyCount":72,"monoclonalCount":36,"pubmedCount":null,"jensenScore":22.838145,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":42.31794393103721,"pubTatorScore":1.067655215874052,"self":"https://pharos.nih.gov/idg/api/v1/targets(3346)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(3346)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(3346)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(3346)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3346)/publications"},"_namespace":null},{"id":3347,"version":3,"created":1554877049000,"modified":1555034714000,"deprecated":false,"name":"Relaxin receptor 1","accession":"Q9HBX9","gene":"RXFP1","description":"Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.21377047046579,"antibodyCount":266,"monoclonalCount":39,"pubmedCount":null,"jensenScore":176.7287,"patentCount":7580,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":81,"knowledgeAvailability":22.802493247007224,"pubTatorScore":2.058461939581124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3347)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(3347)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(3347)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(3347)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3347)/publications"},"_namespace":null},{"id":3348,"version":3,"created":1554877053000,"modified":1555034716000,"deprecated":false,"name":"Leucine-rich repeat-containing G-protein coupled receptor 6","accession":"Q9HBX8","gene":"LGR6","description":"Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.4190641955943497,"antibodyCount":156,"monoclonalCount":45,"pubmedCount":null,"jensenScore":26.493261,"patentCount":12734,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":30.731365777213547,"pubTatorScore":1.7790137779760862,"self":"https://pharos.nih.gov/idg/api/v1/targets(3348)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(3348)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(3348)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3348)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3348)/publications"},"_namespace":null},{"id":3349,"version":3,"created":1554877057000,"modified":1555034717000,"deprecated":false,"name":"Serine/threonine-protein kinase Nek6","accession":"Q9HC98","gene":"NEK6","description":"Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.537239741972634,"antibodyCount":188,"monoclonalCount":51,"pubmedCount":null,"jensenScore":36.611873,"patentCount":5218,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.212741051896025,"pubTatorScore":1.566002756272962,"self":"https://pharos.nih.gov/idg/api/v1/targets(3349)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(3349)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3349)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3349)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3349)/publications"},"_namespace":null},{"id":3350,"version":2,"created":1554877061000,"modified":1554877061000,"deprecated":false,"name":"Uncharacterized protein encoded by SND1-IT1","accession":"Q9HBX3","gene":"SND1-IT1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.732394403027106,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3350)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3350)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3350)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3350)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3350)/publications"},"_namespace":null},{"id":3351,"version":2,"created":1554877061000,"modified":1554877061000,"deprecated":false,"name":"Putative uncharacterized protein FLJ36797","accession":"Q8N9P0","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3351)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3351)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3351)/links"},"_synonyms":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3351)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3351)/publications"},"_namespace":null},{"id":3352,"version":3,"created":1554877061000,"modified":1555034718000,"deprecated":false,"name":"Baculoviral IAP repeat-containing protein 3","accession":"Q13489","gene":"BIRC3","description":"Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.6255266109360247,"antibodyCount":500,"monoclonalCount":151,"pubmedCount":null,"jensenScore":373.209902,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.210115840422205,"pubTatorScore":2.5120442165790884,"self":"https://pharos.nih.gov/idg/api/v1/targets(3352)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":566,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/properties"},"_links":{"count":1221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/synonyms"},"_publications":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(3352)/publications"},"_namespace":null},{"id":3353,"version":3,"created":1554877104000,"modified":1555034720000,"deprecated":false,"name":"V-type proton ATPase 116 kDa subunit a isoform 3","accession":"Q13488","gene":"TCIRG1","description":"Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9234476618835166,"antibodyCount":63,"monoclonalCount":15,"pubmedCount":null,"jensenScore":93.54216,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.411757261201515,"pubTatorScore":2.0878658876770317,"self":"https://pharos.nih.gov/idg/api/v1/targets(3353)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(3353)/properties"},"_links":{"count":1175,"href":"https://pharos.nih.gov/idg/api/v1/targets(3353)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3353)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(3353)/publications"},"_namespace":null},{"id":3354,"version":2,"created":1554877109000,"modified":1554877111000,"deprecated":false,"name":"snRNA-activating protein complex subunit 2","accession":"Q13487","gene":"SNAPC2","description":"Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5482378119823216,"antibodyCount":130,"monoclonalCount":9,"pubmedCount":null,"jensenScore":3.004938,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.533662199843686,"pubTatorScore":0.7871367230121106,"self":"https://pharos.nih.gov/idg/api/v1/targets(3354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3354)/publications"},"_namespace":null},{"id":3355,"version":3,"created":1554877112000,"modified":1555034722000,"deprecated":false,"name":"Cytohesin-4","accession":"Q9UIA0","gene":"CYTH4","description":"Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0386615009344742,"antibodyCount":145,"monoclonalCount":7,"pubmedCount":null,"jensenScore":11.346341,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":30.001247288337694,"pubTatorScore":0.8624721190525231,"self":"https://pharos.nih.gov/idg/api/v1/targets(3355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(3355)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(3355)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3355)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3355)/publications"},"_namespace":null},{"id":3356,"version":3,"created":1554877115000,"modified":1555034724000,"deprecated":false,"name":"A-kinase anchor protein 14","accession":"Q86UN6","gene":"AKAP14","description":"Binds to type II regulatory subunits of protein kinase A and anchors/targets them.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.3010299956639812,"antibodyCount":69,"monoclonalCount":5,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":15.06940567878634,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(3356)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(3356)/properties"},"_links":{"count":514,"href":"https://pharos.nih.gov/idg/api/v1/targets(3356)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3356)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3356)/publications"},"_namespace":null},{"id":3357,"version":2,"created":1554877117000,"modified":1554877121000,"deprecated":false,"name":"Ankyrin-2","accession":"Q01484","gene":"ANK2","description":"In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors (By similarity). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0842124807154345,"antibodyCount":236,"monoclonalCount":208,"pubmedCount":null,"jensenScore":120.472081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.13871029594798,"pubTatorScore":1.8650182033803437,"self":"https://pharos.nih.gov/idg/api/v1/targets(3357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/properties"},"_links":{"count":1223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3357)/publications"},"_namespace":null},{"id":3358,"version":2,"created":1554877123000,"modified":1554877123000,"deprecated":false,"name":"Uncharacterized protein C9orf163","accession":"Q8N9P6","gene":"C9orf163","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/properties"},"_links":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3358)/publications"},"_namespace":null},{"id":3359,"version":2,"created":1554877123000,"modified":1554877125000,"deprecated":false,"name":"Reticulon-4 receptor-like 2","accession":"Q86UN3","gene":"RTN4RL2","description":"Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1191595508645773,"antibodyCount":90,"monoclonalCount":20,"pubmedCount":null,"jensenScore":14.451902,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.826100848078237,"pubTatorScore":0.9736408034699406,"self":"https://pharos.nih.gov/idg/api/v1/targets(3359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3359)/publications"},"_namespace":null},{"id":3360,"version":2,"created":1554877126000,"modified":1554877128000,"deprecated":false,"name":"Reticulon-4 receptor-like 1","accession":"Q86UN2","gene":"RTN4RL1","description":"Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8133373785276958,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.427447,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.095940149222493,"pubTatorScore":0.7856121770181471,"self":"https://pharos.nih.gov/idg/api/v1/targets(3360)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3360)/publications"},"_namespace":null},{"id":3361,"version":2,"created":1554877129000,"modified":1554877131000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 2B","accession":"A6NFX1","gene":"MFSD2B","description":"Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4051185965563696,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.187179,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.681552101364087,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/properties"},"_links":{"count":709,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3361)/publications"},"_namespace":null},{"id":3362,"version":2,"created":1554877132000,"modified":1554877134000,"deprecated":false,"name":"Zinc finger protein 251","accession":"Q9BRH9","gene":"ZNF251","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.3672350361350055,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.326705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.394590912001675,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3362)/publications"},"_namespace":null},{"id":3363,"version":3,"created":1554877134000,"modified":1555034724000,"deprecated":false,"name":"Probable lysosomal cobalamin transporter","accession":"Q9NUN5","gene":"LMBRD1","description":"Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1051751581185276,"antibodyCount":54,"monoclonalCount":2,"pubmedCount":null,"jensenScore":126.109666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.97476067727002,"pubTatorScore":1.227653022161968,"self":"https://pharos.nih.gov/idg/api/v1/targets(3363)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3363)/publications"},"_namespace":null},{"id":3364,"version":2,"created":1554877138000,"modified":1554877141000,"deprecated":false,"name":"Exportin-7","accession":"Q9UIA9","gene":"XPO7","description":"Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0189348382146024,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.194851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.653219252173244,"pubTatorScore":0.8050475689421027,"self":"https://pharos.nih.gov/idg/api/v1/targets(3364)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3364)/publications"},"_namespace":null},{"id":3365,"version":2,"created":1554877141000,"modified":1554877144000,"deprecated":false,"name":"Alkaline ceramidase 3","accession":"Q9NUN7","gene":"ACER3","description":"Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0793815888652842,"antibodyCount":95,"monoclonalCount":0,"pubmedCount":null,"jensenScore":117.110113,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.70953100112161,"pubTatorScore":1.0743287554524958,"self":"https://pharos.nih.gov/idg/api/v1/targets(3365)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(3365)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(3365)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3365)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3365)/publications"},"_namespace":null},{"id":3366,"version":3,"created":1554877144000,"modified":1555034726000,"deprecated":false,"name":"Phosphatidylinositol-binding clathrin assembly protein","accession":"Q13492","gene":"PICALM","description":"Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.928621403460395,"antibodyCount":130,"monoclonalCount":36,"pubmedCount":null,"jensenScore":84.708648,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":51.70041437421891,"pubTatorScore":1.9855199788013005,"self":"https://pharos.nih.gov/idg/api/v1/targets(3366)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":571,"href":"https://pharos.nih.gov/idg/api/v1/targets(3366)/properties"},"_links":{"count":1391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3366)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3366)/synonyms"},"_publications":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3366)/publications"},"_namespace":null},{"id":3367,"version":2,"created":1554877149000,"modified":1554877152000,"deprecated":false,"name":"Adhesion G protein-coupled receptor L4","accession":"Q9HBW9","gene":"ADGRL4","description":"Endothelial orphan receptor that acts as a key regulator of angiogenesis.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-2.276279234752231,"antibodyCount":140,"monoclonalCount":5,"pubmedCount":null,"jensenScore":174.260892,"patentCount":13191,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.022779779514508,"pubTatorScore":1.175017834223591,"self":"https://pharos.nih.gov/idg/api/v1/targets(3367)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(3367)/properties"},"_links":{"count":840,"href":"https://pharos.nih.gov/idg/api/v1/targets(3367)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3367)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3367)/publications"},"_namespace":null},{"id":3368,"version":3,"created":1554877152000,"modified":1555034728000,"deprecated":false,"name":"Neuronal membrane glycoprotein M6-b","accession":"Q13491","gene":"GPM6B","description":"May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6760375173440842,"antibodyCount":86,"monoclonalCount":2,"pubmedCount":null,"jensenScore":47.782236,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.554268564899864,"pubTatorScore":1.5026546416102746,"self":"https://pharos.nih.gov/idg/api/v1/targets(3368)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(3368)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3368)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3368)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3368)/publications"},"_namespace":null},{"id":3369,"version":4,"created":1554877156000,"modified":1555034729000,"deprecated":false,"name":"Baculoviral IAP repeat-containing protein 2","accession":"Q13490","gene":"BIRC2","description":"Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.534227648081294,"antibodyCount":351,"monoclonalCount":44,"pubmedCount":null,"jensenScore":308.71167,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":49.368927976929854,"pubTatorScore":2.414922589342672,"self":"https://pharos.nih.gov/idg/api/v1/targets(3369)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":639,"href":"https://pharos.nih.gov/idg/api/v1/targets(3369)/properties"},"_links":{"count":1506,"href":"https://pharos.nih.gov/idg/api/v1/targets(3369)/links"},"_synonyms":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(3369)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(3369)/publications"},"_namespace":null},{"id":3370,"version":3,"created":1554877252000,"modified":1555034732000,"deprecated":false,"name":"Myotubularin","accession":"Q13496","gene":"MTM1","description":"Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.725071269577345,"antibodyCount":235,"monoclonalCount":10,"pubmedCount":null,"jensenScore":527.34422,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":39.00619433703778,"pubTatorScore":2.1854319666280095,"self":"https://pharos.nih.gov/idg/api/v1/targets(3370)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3370)/publications"},"_namespace":null},{"id":3371,"version":2,"created":1554877258000,"modified":1554877261000,"deprecated":false,"name":"Mastermind-like domain-containing protein 1","accession":"Q13495","gene":"MAMLD1","description":"Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9773164063067559,"antibodyCount":52,"monoclonalCount":14,"pubmedCount":null,"jensenScore":91.226868,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.76646553085784,"pubTatorScore":3.045241458757026,"self":"https://pharos.nih.gov/idg/api/v1/targets(3371)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(3371)/properties"},"_links":{"count":842,"href":"https://pharos.nih.gov/idg/api/v1/targets(3371)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3371)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3371)/publications"},"_namespace":null},{"id":3372,"version":2,"created":1554877262000,"modified":1554877265000,"deprecated":false,"name":"Nuclear envelope integral membrane protein 2","accession":"A6NFY4","gene":"NEMP2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4296966044017729,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.272727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.019305344019033388,"self":"https://pharos.nih.gov/idg/api/v1/targets(3372)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(3372)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(3372)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3372)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3372)/publications"},"_namespace":null},{"id":3373,"version":3,"created":1554877266000,"modified":1555034734000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 4","accession":"Q9HBW1","gene":"LRRC4","description":"Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2985802011233805,"antibodyCount":70,"monoclonalCount":9,"pubmedCount":null,"jensenScore":23.513502,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":23.646426859222046,"pubTatorScore":1.3687670216297476,"self":"https://pharos.nih.gov/idg/api/v1/targets(3373)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3373)/publications"},"_namespace":null},{"id":3374,"version":2,"created":1554877271000,"modified":1554877275000,"deprecated":false,"name":"Mucin-5B","accession":"Q9HC84","gene":"MUC5B","description":"Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.2032245226424427,"antibodyCount":177,"monoclonalCount":70,"pubmedCount":null,"jensenScore":1552.242981,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.222877305555215,"pubTatorScore":2.6946176739730583,"self":"https://pharos.nih.gov/idg/api/v1/targets(3374)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(3374)/publications"},"_namespace":null},{"id":3375,"version":3,"created":1554877277000,"modified":1555034735000,"deprecated":false,"name":"Succinate dehydrogenase assembly factor 1, mitochondrial","accession":"A6NFY7","gene":"SDHAF1","description":"Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6943962541054609,"antibodyCount":110,"monoclonalCount":14,"pubmedCount":null,"jensenScore":4.589609,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":23.267317710249884,"pubTatorScore":0.7353453541976855,"self":"https://pharos.nih.gov/idg/api/v1/targets(3375)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3375)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(3375)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3375)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3375)/publications"},"_namespace":null},{"id":3376,"version":3,"created":1554877281000,"modified":1555034736000,"deprecated":false,"name":"Lysophosphatidic acid receptor 2","accession":"Q9HBW0","gene":"LPAR2","description":"Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.9839361351506242,"antibodyCount":265,"monoclonalCount":4,"pubmedCount":null,"jensenScore":89.313873,"patentCount":14243,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.09224011138864,"pubTatorScore":1.9348154916639104,"self":"https://pharos.nih.gov/idg/api/v1/targets(3376)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3376)/publications"},"_namespace":null},{"id":3377,"version":3,"created":1554877295000,"modified":1555034738000,"deprecated":false,"name":"Membrane-anchored junction protein","accession":"Q3KP22","gene":"MAJIN","description":"Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.24303804977203064,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.794259,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3377)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/properties"},"_links":{"count":626,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3377)/publications"},"_namespace":null},{"id":3378,"version":2,"created":1554877297000,"modified":1554877299000,"deprecated":false,"name":"SLAM family member 5","accession":"Q9UIB8","gene":"CD84","description":"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4394057483061724,"antibodyCount":450,"monoclonalCount":248,"pubmedCount":null,"jensenScore":29.726635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.29832592218222,"pubTatorScore":1.3896400751868576,"self":"https://pharos.nih.gov/idg/api/v1/targets(3378)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3378)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(3378)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3378)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3378)/publications"},"_namespace":null},{"id":3379,"version":2,"created":1554877300000,"modified":1554877308000,"deprecated":false,"name":"Fatty acid-binding protein, epidermal","accession":"Q01469","gene":"FABP5","description":"High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.9422901646095219,"antibodyCount":226,"monoclonalCount":32,"pubmedCount":null,"jensenScore":141.219285,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.59996692682336,"pubTatorScore":1.9443383192747128,"self":"https://pharos.nih.gov/idg/api/v1/targets(3379)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(3379)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(3379)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3379)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3379)/publications"},"_namespace":null},{"id":3380,"version":2,"created":1554877309000,"modified":1554877311000,"deprecated":false,"name":"Tetratricopeptide repeat protein 34","accession":"A8MYJ7","gene":"TTC34","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3448421543972675,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.801447491066607,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3380)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(3380)/properties"},"_links":{"count":680,"href":"https://pharos.nih.gov/idg/api/v1/targets(3380)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3380)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3380)/publications"},"_namespace":null},{"id":3381,"version":2,"created":1554877311000,"modified":1554877314000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 13","accession":"Q9NV06","gene":"DCAF13","description":"Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6340292058476192,"antibodyCount":86,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.770647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.49404557009818,"pubTatorScore":0.506655318289732,"self":"https://pharos.nih.gov/idg/api/v1/targets(3381)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(3381)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(3381)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3381)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3381)/publications"},"_namespace":null},{"id":3382,"version":2,"created":1554877315000,"modified":1554877317000,"deprecated":false,"name":"SH2 domain-containing protein 3A","accession":"Q9BRG2","gene":"SH2D3A","description":"May play a role in JNK activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4755934913062956,"antibodyCount":103,"monoclonalCount":7,"pubmedCount":null,"jensenScore":291.408941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.298221282936566,"pubTatorScore":2.3113216077471317,"self":"https://pharos.nih.gov/idg/api/v1/targets(3382)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(3382)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3382)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3382)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3382)/publications"},"_namespace":null},{"id":3383,"version":3,"created":1554877317000,"modified":1555034739000,"deprecated":false,"name":"Vacuolar protein-sorting-associated protein 25","accession":"Q9BRG1","gene":"VPS25","description":"Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2144653829124183,"antibodyCount":154,"monoclonalCount":14,"pubmedCount":null,"jensenScore":17.654344,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":33.20697252580072,"pubTatorScore":0.9226142498404117,"self":"https://pharos.nih.gov/idg/api/v1/targets(3383)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(3383)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(3383)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3383)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3383)/publications"},"_namespace":null},{"id":3384,"version":2,"created":1554877320000,"modified":1554877324000,"deprecated":false,"name":"Zinc finger and BTB domain-containing protein 20","accession":"Q9HC78","gene":"ZBTB20","description":"May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1442083600723545,"antibodyCount":85,"monoclonalCount":16,"pubmedCount":null,"jensenScore":133.107294,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.65173980338052,"pubTatorScore":1.3718577073981304,"self":"https://pharos.nih.gov/idg/api/v1/targets(3384)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(3384)/properties"},"_links":{"count":1206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3384)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3384)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3384)/publications"},"_namespace":null},{"id":3385,"version":2,"created":1554877325000,"modified":1554877328000,"deprecated":false,"name":"Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1","accession":"Q8WUK0","gene":"PTPMT1","description":"Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3624316242764876,"antibodyCount":109,"monoclonalCount":7,"pubmedCount":null,"jensenScore":22.958218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.42953485021968,"pubTatorScore":1.097451362292515,"self":"https://pharos.nih.gov/idg/api/v1/targets(3385)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3385)/publications"},"_namespace":null},{"id":3386,"version":2,"created":1554877329000,"modified":1554877332000,"deprecated":false,"name":"Centromere protein J","accession":"Q9HC77","gene":"CENPJ","description":"Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.795883003128902,"antibodyCount":102,"monoclonalCount":38,"pubmedCount":null,"jensenScore":58.974421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.05774909519603,"pubTatorScore":3.1368894137016032,"self":"https://pharos.nih.gov/idg/api/v1/targets(3386)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(3386)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(3386)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3386)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3386)/publications"},"_namespace":null},{"id":3387,"version":2,"created":1554877332000,"modified":1554877333000,"deprecated":false,"name":"Fibrous sheath CABYR-binding protein","accession":"Q5H9T9","gene":"FSCB","description":"May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5188271765280196,"antibodyCount":75,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.758607,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.240740180197639,"pubTatorScore":0.2518119035066769,"self":"https://pharos.nih.gov/idg/api/v1/targets(3387)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3387)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3387)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3387)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3387)/publications"},"_namespace":null},{"id":3388,"version":3,"created":1554877333000,"modified":1555034740000,"deprecated":false,"name":"Popeye domain-containing protein 3","accession":"Q9HBV1","gene":"POPDC3","description":"May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6327464391474157,"antibodyCount":89,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.990635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.641889903907263,"pubTatorScore":1.0338531327841038,"self":"https://pharos.nih.gov/idg/api/v1/targets(3388)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(3388)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(3388)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3388)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3388)/publications"},"_namespace":null},{"id":3389,"version":2,"created":1554877336000,"modified":1554877337000,"deprecated":false,"name":"Cytokine receptor-like factor 2","accession":"Q9HC73","gene":"CRLF2","description":"Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9111257066390859,"antibodyCount":393,"monoclonalCount":187,"pubmedCount":null,"jensenScore":78.695925,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.87447563523315,"pubTatorScore":1.9028700860335193,"self":"https://pharos.nih.gov/idg/api/v1/targets(3389)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(3389)/properties"},"_links":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(3389)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3389)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3389)/publications"},"_namespace":null},{"id":3390,"version":3,"created":1554877338000,"modified":1555034743000,"deprecated":false,"name":"Sperm acrosome membrane-associated protein 1","accession":"Q9HBV2","gene":"SPACA1","description":"May be involved in sperm-egg fusion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7829501460047174,"antibodyCount":95,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.711905,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":23.061825002916812,"pubTatorScore":0.7468934529410741,"self":"https://pharos.nih.gov/idg/api/v1/targets(3390)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3390)/properties"},"_links":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(3390)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3390)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3390)/publications"},"_namespace":null},{"id":3391,"version":3,"created":1554877338000,"modified":1555034744000,"deprecated":false,"name":"Activating signal cointegrator 1 complex subunit 1","accession":"Q8N9N2","gene":"ASCC1","description":"Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.22831479548470876,"antibodyCount":95,"monoclonalCount":29,"pubmedCount":null,"jensenScore":2.47619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":33.973380642660096,"pubTatorScore":1.5268518687966057,"self":"https://pharos.nih.gov/idg/api/v1/targets(3391)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(3391)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(3391)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3391)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3391)/publications"},"_namespace":null},{"id":3392,"version":3,"created":1554877341000,"modified":1555034746000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 57","accession":"Q8N9N7","gene":"LRRC57","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":111,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":24.911760371615884,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3392)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(3392)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(3392)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3392)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3392)/publications"},"_namespace":null},{"id":3393,"version":3,"created":1554877344000,"modified":1555034747000,"deprecated":false,"name":"Glycerol-3-phosphate acyltransferase 4","accession":"Q86UL3","gene":"GPAT4","description":"Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6197205432211133,"antibodyCount":205,"monoclonalCount":21,"pubmedCount":null,"jensenScore":41.315177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":0.9323891298893588,"self":"https://pharos.nih.gov/idg/api/v1/targets(3393)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(3393)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(3393)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3393)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3393)/publications"},"_namespace":null},{"id":3394,"version":2,"created":1554877347000,"modified":1554877350000,"deprecated":false,"name":"Protein BANP","accession":"Q8N9N5","gene":"BANP","description":"Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6781243474407972,"antibodyCount":92,"monoclonalCount":6,"pubmedCount":null,"jensenScore":53.325377,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.95997387199326,"pubTatorScore":1.429073200559514,"self":"https://pharos.nih.gov/idg/api/v1/targets(3394)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(3394)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3394)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3394)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3394)/publications"},"_namespace":null},{"id":3395,"version":2,"created":1554877351000,"modified":1554877353000,"deprecated":false,"name":"SH3 domain-binding protein 1","accession":"Q9Y3L3","gene":"SH3BP1","description":"GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":168,"monoclonalCount":8,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.457742699268433,"pubTatorScore":0.8922491394850206,"self":"https://pharos.nih.gov/idg/api/v1/targets(3395)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(3395)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(3395)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3395)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3395)/publications"},"_namespace":null},{"id":3396,"version":3,"created":1554877353000,"modified":1555034749000,"deprecated":false,"name":"Probable RNA-binding protein EIF1AD","accession":"Q8N9N8","gene":"EIF1AD","description":"Plays a role into cellular response to oxidative stress. Decreases cell proliferation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.45229766665168547,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.436364,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":30.387505470684516,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(3396)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3396)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(3396)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3396)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3396)/publications"},"_namespace":null},{"id":3397,"version":3,"created":1554877356000,"modified":1555034750000,"deprecated":false,"name":"Ras-related protein Rap-2c","accession":"Q9Y3L5","gene":"RAP2C","description":"Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.629482413894685,"antibodyCount":101,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.673408,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":35.57710170207104,"pubTatorScore":0.6691175429469864,"self":"https://pharos.nih.gov/idg/api/v1/targets(3397)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3397)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(3397)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3397)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3397)/publications"},"_namespace":null},{"id":3398,"version":3,"created":1554877359000,"modified":1555034752000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase FKBP4","accession":"Q02790","gene":"FKBP4","description":"Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.699819881073603,"antibodyCount":446,"monoclonalCount":229,"pubmedCount":null,"jensenScore":543.349321,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":45.097329385839366,"pubTatorScore":2.2213785407597832,"self":"https://pharos.nih.gov/idg/api/v1/targets(3398)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":515,"href":"https://pharos.nih.gov/idg/api/v1/targets(3398)/properties"},"_links":{"count":1201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3398)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(3398)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3398)/publications"},"_namespace":null},{"id":3399,"version":2,"created":1554877366000,"modified":1554877366000,"deprecated":false,"name":"Protein FAM24A","accession":"A6NFZ4","gene":"FAM24A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.55753256199167,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3399)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3399)/properties"},"_links":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3399)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3399)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3399)/publications"},"_namespace":null},{"id":3400,"version":2,"created":1554877366000,"modified":1554877368000,"deprecated":false,"name":"Biogenesis of lysosome-related organelles complex 1 subunit 4","accession":"Q9NUP1","gene":"BLOC1S4","description":"Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":53,"monoclonalCount":24,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.40396853047462,"pubTatorScore":2.1454590888074416,"self":"https://pharos.nih.gov/idg/api/v1/targets(3400)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(3400)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(3400)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3400)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3400)/publications"},"_namespace":null},{"id":3401,"version":3,"created":1554877369000,"modified":1555034753000,"deprecated":false,"name":"Transmembrane protein 140","accession":"Q9NV12","gene":"TMEM140","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.50358118338123,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.068765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.800388151494268,"pubTatorScore":0.5496719775470503,"self":"https://pharos.nih.gov/idg/api/v1/targets(3401)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3401)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(3401)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3401)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3401)/publications"},"_namespace":null},{"id":3402,"version":3,"created":1554877372000,"modified":1555034754000,"deprecated":false,"name":"Serine/threonine-protein phosphatase CPPED1","accession":"Q9BRF8","gene":"CPPED1","description":"Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8851871924548902,"antibodyCount":101,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.698081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.102219600092894,"pubTatorScore":0.5432719357970041,"self":"https://pharos.nih.gov/idg/api/v1/targets(3402)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(3402)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(3402)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3402)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3402)/publications"},"_namespace":null},{"id":3403,"version":3,"created":1554877375000,"modified":1555034756000,"deprecated":false,"name":"Leucine carboxyl methyltransferase 1","accession":"Q9UIC8","gene":"LCMT1","description":"Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2631285835404185,"antibodyCount":137,"monoclonalCount":79,"pubmedCount":null,"jensenScore":16.514142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.58243874545457,"pubTatorScore":1.0440635000521974,"self":"https://pharos.nih.gov/idg/api/v1/targets(3403)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(3403)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(3403)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(3403)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3403)/publications"},"_namespace":null},{"id":3404,"version":2,"created":1554877378000,"modified":1554877381000,"deprecated":false,"name":"Di-N-acetylchitobiase","accession":"Q01459","gene":"CTBS","description":"Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.283264818980461,"antibodyCount":113,"monoclonalCount":19,"pubmedCount":null,"jensenScore":196.400873,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.187965102481286,"pubTatorScore":1.8267944284627764,"self":"https://pharos.nih.gov/idg/api/v1/targets(3404)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3404)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(3404)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3404)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3404)/publications"},"_namespace":null},{"id":3405,"version":2,"created":1554877381000,"modified":1554877385000,"deprecated":false,"name":"Peripheral myelin protein 22","accession":"Q01453","gene":"PMP22","description":"Might be involved in growth regulation, and in myelinization in the peripheral nervous system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.506116924891247,"antibodyCount":262,"monoclonalCount":73,"pubmedCount":null,"jensenScore":344.385225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.7717759837883,"pubTatorScore":2.7831244429362987,"self":"https://pharos.nih.gov/idg/api/v1/targets(3405)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(3405)/properties"},"_links":{"count":1048,"href":"https://pharos.nih.gov/idg/api/v1/targets(3405)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3405)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(3405)/publications"},"_namespace":null},{"id":3406,"version":2,"created":1554877386000,"modified":1554877389000,"deprecated":false,"name":"Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2","accession":"Q86UL8","gene":"MAGI2","description":"Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.541701108439796,"antibodyCount":178,"monoclonalCount":29,"pubmedCount":null,"jensenScore":32.966132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.888227841725076,"pubTatorScore":1.581349214314441,"self":"https://pharos.nih.gov/idg/api/v1/targets(3406)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(3406)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(3406)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(3406)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3406)/publications"},"_namespace":null},{"id":3407,"version":3,"created":1554877390000,"modified":1555034757000,"deprecated":false,"name":"tRNA:m(4)X modification enzyme TRM13 homolog","accession":"Q9NUP7","gene":"TRMT13","description":"tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":33,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.129168302387942,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3407)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(3407)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(3407)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3407)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3407)/publications"},"_namespace":null},{"id":3408,"version":3,"created":1554877393000,"modified":1555034759000,"deprecated":false,"name":"Protein lin-7 homolog C","accession":"Q9NUP9","gene":"LIN7C","description":"Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0122009649179828,"antibodyCount":110,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.553953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":38.7862619914175,"pubTatorScore":0.8423226729650887,"self":"https://pharos.nih.gov/idg/api/v1/targets(3408)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(3408)/properties"},"_links":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(3408)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3408)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3408)/publications"},"_namespace":null},{"id":3409,"version":2,"created":1554877396000,"modified":1554877399000,"deprecated":false,"name":"Cell migration-inducing and hyaluronan-binding protein","accession":"Q8WUJ3","gene":"CEMIP","description":"Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5821041841684877,"antibodyCount":144,"monoclonalCount":34,"pubmedCount":null,"jensenScore":41.542305,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.930394208842394,"pubTatorScore":1.3776581347564214,"self":"https://pharos.nih.gov/idg/api/v1/targets(3409)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(3409)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(3409)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3409)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3409)/publications"},"_namespace":null},{"id":3410,"version":3,"created":1554877400000,"modified":1555034761000,"deprecated":false,"name":"Neuferricin","accession":"Q8WUJ1","gene":"CYB5D2","description":"Heme-binding protein which promotes neuronal but not astrocyte differentiation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5091268539351365,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.8688,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":27.234649318328174,"pubTatorScore":0.5006023962843915,"self":"https://pharos.nih.gov/idg/api/v1/targets(3410)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(3410)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(3410)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3410)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3410)/publications"},"_namespace":null},{"id":3411,"version":3,"created":1554877402000,"modified":1555034762000,"deprecated":false,"name":"Popeye domain-containing protein 2","accession":"Q9HBU9","gene":"POPDC2","description":"Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8271538094377423,"antibodyCount":55,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.442086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":22.3688225062391,"pubTatorScore":0.1929917841585205,"self":"https://pharos.nih.gov/idg/api/v1/targets(3411)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(3411)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(3411)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3411)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3411)/publications"},"_namespace":null},{"id":3412,"version":2,"created":1554877404000,"modified":1554877407000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX60-like","accession":"Q5H9U9","gene":"DDX60L","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.2255725704832566,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.828065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.42301267585847,"pubTatorScore":-0.17351443235952124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3412)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(3412)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(3412)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3412)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3412)/publications"},"_namespace":null},{"id":3413,"version":3,"created":1554877407000,"modified":1555034763000,"deprecated":false,"name":"Serine/threonine/tyrosine-interacting protein","accession":"Q8WUJ0","gene":"STYX","description":"Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7320106899935808,"antibodyCount":36,"monoclonalCount":3,"pubmedCount":null,"jensenScore":50.262194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.106085413542182,"pubTatorScore":1.2700962814203305,"self":"https://pharos.nih.gov/idg/api/v1/targets(3413)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(3413)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(3413)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3413)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3413)/publications"},"_namespace":null},{"id":3414,"version":2,"created":1554877410000,"modified":1554877412000,"deprecated":false,"name":"Ethanolamine kinase 1","accession":"Q9HBU6","gene":"ETNK1","description":"Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.5970187156970646,"antibodyCount":152,"monoclonalCount":34,"pubmedCount":null,"jensenScore":38.843635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.94355161603108,"pubTatorScore":0.7664981359581514,"self":"https://pharos.nih.gov/idg/api/v1/targets(3414)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(3414)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(3414)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3414)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3414)/publications"},"_namespace":null},{"id":3415,"version":3,"created":1554877413000,"modified":1555034765000,"deprecated":false,"name":"Protein FAM124A","accession":"Q86V42","gene":"FAM124A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5190857567774946,"antibodyCount":51,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.313492,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":20.639164863112356,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3415)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3415)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(3415)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3415)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3415)/publications"},"_namespace":null},{"id":3416,"version":2,"created":1554877415000,"modified":1554877417000,"deprecated":false,"name":"Metalloprotease TIKI1","accession":"Q86V40","gene":"TRABD2A","description":"Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4648868019217715,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.809524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.388898324462218,"pubTatorScore":0.568201724066995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3416)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3416)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(3416)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3416)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3416)/publications"},"_namespace":null},{"id":3417,"version":2,"created":1554877418000,"modified":1554877418000,"deprecated":false,"name":"Putative uncharacterized protein SPANXA2-OT1","accession":"Q8N9U9","gene":"SPANXA2-OT1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.9256402856978925,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3417)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3417)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3417)/links"},"_synonyms":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3417)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3417)/publications"},"_namespace":null},{"id":3418,"version":2,"created":1554877418000,"modified":1554877419000,"deprecated":false,"name":"Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y","accession":"Q3MUY2","gene":"PIGY","description":"Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.2579450943855736,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.85,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.498475954600536,"pubTatorScore":0.3256523337866281,"self":"https://pharos.nih.gov/idg/api/v1/targets(3418)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3418)/properties"},"_links":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3418)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(3418)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3418)/publications"},"_namespace":null},{"id":3419,"version":2,"created":1554877419000,"modified":1554877421000,"deprecated":false,"name":"Vesicle transport protein GOT1B","accession":"Q9Y3E0","gene":"GOLT1B","description":"May be involved in fusion of ER-derived transport vesicles with the Golgi complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.716003348846333,"antibodyCount":47,"monoclonalCount":1,"pubmedCount":null,"jensenScore":5.849084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.296346918911954,"pubTatorScore":0.33579216873772366,"self":"https://pharos.nih.gov/idg/api/v1/targets(3419)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(3419)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(3419)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3419)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3419)/publications"},"_namespace":null},{"id":3420,"version":3,"created":1554877422000,"modified":1555034765000,"deprecated":false,"name":"BolA-like protein 1","accession":"Q9Y3E2","gene":"BOLA1","description":"Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.722908007129251,"antibodyCount":118,"monoclonalCount":30,"pubmedCount":null,"jensenScore":5.344817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":28.4350375891659,"pubTatorScore":0.3832166320459405,"self":"https://pharos.nih.gov/idg/api/v1/targets(3420)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3420)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(3420)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3420)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3420)/publications"},"_namespace":null},{"id":3421,"version":2,"created":1554877425000,"modified":1554877427000,"deprecated":false,"name":"Hepatoma-derived growth factor-related protein 3","accession":"Q9Y3E1","gene":"HDGFL3","description":"Enhances DNA synthesis and may play a role in cell proliferation.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.42050583135924524,"antibodyCount":139,"monoclonalCount":27,"pubmedCount":null,"jensenScore":3.291667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.9754318544663486,"self":"https://pharos.nih.gov/idg/api/v1/targets(3421)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(3421)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(3421)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3421)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3421)/publications"},"_namespace":null},{"id":3422,"version":2,"created":1554877428000,"modified":1554877430000,"deprecated":false,"name":"Leucine zipper protein 1","accession":"Q86V48","gene":"LUZP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5644094552315512,"antibodyCount":85,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.92055051596727,"pubTatorScore":-0.13894913778963408,"self":"https://pharos.nih.gov/idg/api/v1/targets(3422)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(3422)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(3422)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3422)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3422)/publications"},"_namespace":null},{"id":3423,"version":2,"created":1554877431000,"modified":1554877434000,"deprecated":false,"name":"Telomerase-binding protein EST1A","accession":"Q86US8","gene":"SMG6","description":"Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4878760397219737,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":32.60708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.92235583410952,"pubTatorScore":1.454977855661234,"self":"https://pharos.nih.gov/idg/api/v1/targets(3423)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(3423)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(3423)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3423)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(3423)/publications"},"_namespace":null},{"id":3424,"version":3,"created":1554877435000,"modified":1555034767000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 55","accession":"Q3KP44","gene":"ANKRD55","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7698098163640292,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.228295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":27.813681574675666,"pubTatorScore":0.7404335921506662,"self":"https://pharos.nih.gov/idg/api/v1/targets(3424)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(3424)/properties"},"_links":{"count":754,"href":"https://pharos.nih.gov/idg/api/v1/targets(3424)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3424)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3424)/publications"},"_namespace":null},{"id":3425,"version":3,"created":1554877437000,"modified":1555034768000,"deprecated":false,"name":"Non-structural maintenance of chromosomes element 1 homolog","accession":"Q8WV22","gene":"NSMCE1","description":"Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":103,"monoclonalCount":5,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":31.624263298883413,"pubTatorScore":0.712340198633113,"self":"https://pharos.nih.gov/idg/api/v1/targets(3425)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(3425)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(3425)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3425)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3425)/publications"},"_namespace":null},{"id":3426,"version":2,"created":1554877440000,"modified":1554877443000,"deprecated":false,"name":"Charged multivesicular body protein 3","accession":"Q9Y3E7","gene":"CHMP3","description":"Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3965798675537744,"antibodyCount":64,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.551808,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.08706871828794,"pubTatorScore":1.3911031959671054,"self":"https://pharos.nih.gov/idg/api/v1/targets(3426)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(3426)/properties"},"_links":{"count":1167,"href":"https://pharos.nih.gov/idg/api/v1/targets(3426)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3426)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3426)/publications"},"_namespace":null},{"id":3427,"version":2,"created":1554877444000,"modified":1554877449000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 10","accession":"Q02779","gene":"MAP3K10","description":"Activates the JUN N-terminal pathway.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.200479772527343,"antibodyCount":221,"monoclonalCount":14,"pubmedCount":null,"jensenScore":15.124193,"patentCount":36184,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.722418827940814,"pubTatorScore":1.4850661411828976,"self":"https://pharos.nih.gov/idg/api/v1/targets(3427)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(3427)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(3427)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3427)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3427)/publications"},"_namespace":null},{"id":3428,"version":3,"created":1554877449000,"modified":1554878122000,"deprecated":false,"name":"Sigma non-opioid intracellular receptor 1","accession":"Q99720","gene":"SIGMAR1","description":"Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.289069834559971,"antibodyCount":143,"monoclonalCount":5,"pubmedCount":null,"jensenScore":209.968464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.25850720101233,"pubTatorScore":1.9251055823200307,"self":"https://pharos.nih.gov/idg/api/v1/targets(3428)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":473,"href":"https://pharos.nih.gov/idg/api/v1/targets(3428)/properties"},"_links":{"count":3128,"href":"https://pharos.nih.gov/idg/api/v1/targets(3428)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(3428)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3428)/publications"},"_namespace":null},{"id":3429,"version":2,"created":1554878127000,"modified":1554878129000,"deprecated":false,"name":"Myosin regulatory light chain 2, atrial isoform","accession":"Q01449","gene":"MYL7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8519822165536407,"antibodyCount":169,"monoclonalCount":73,"pubmedCount":null,"jensenScore":5.200653,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.36908340189848,"pubTatorScore":1.1483860704639635,"self":"https://pharos.nih.gov/idg/api/v1/targets(3429)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(3429)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(3429)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3429)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3429)/publications"},"_namespace":null},{"id":3430,"version":3,"created":1554878130000,"modified":1555034769000,"deprecated":false,"name":"Peroxisomal 2,4-dienoyl-CoA reductase","accession":"Q9NUI1","gene":"DECR2","description":"Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3526647657761324,"antibodyCount":112,"monoclonalCount":20,"pubmedCount":null,"jensenScore":22.252654,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.3440498638768,"pubTatorScore":0.6232492903979004,"self":"https://pharos.nih.gov/idg/api/v1/targets(3430)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(3430)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(3430)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3430)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3430)/publications"},"_namespace":null},{"id":3431,"version":2,"created":1554878133000,"modified":1554878136000,"deprecated":false,"name":"Peptidyl-tRNA hydrolase 2, mitochondrial","accession":"Q9Y3E5","gene":"PTRH2","description":"Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5652017149456763,"antibodyCount":293,"monoclonalCount":4,"pubmedCount":null,"jensenScore":39.793184,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.78577713786028,"pubTatorScore":1.2534375035895304,"self":"https://pharos.nih.gov/idg/api/v1/targets(3431)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(3431)/properties"},"_links":{"count":1114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3431)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3431)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3431)/publications"},"_namespace":null},{"id":3432,"version":3,"created":1554878137000,"modified":1555034771000,"deprecated":false,"name":"BRCA1-associated RING domain protein 1","accession":"Q99728","gene":"BARD1","description":"E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0926418543094596,"antibodyCount":236,"monoclonalCount":21,"pubmedCount":null,"jensenScore":120.7109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.32745123351758,"pubTatorScore":2.1535689810276835,"self":"https://pharos.nih.gov/idg/api/v1/targets(3432)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(3432)/properties"},"_links":{"count":1161,"href":"https://pharos.nih.gov/idg/api/v1/targets(3432)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3432)/synonyms"},"_publications":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3432)/publications"},"_namespace":null},{"id":3433,"version":3,"created":1554878142000,"modified":1555034773000,"deprecated":false,"name":"B-cell linker protein","accession":"Q8WV28","gene":"BLNK","description":"Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.82834081602155,"antibodyCount":509,"monoclonalCount":78,"pubmedCount":null,"jensenScore":659.370359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.82346261055557,"pubTatorScore":2.3079815109428026,"self":"https://pharos.nih.gov/idg/api/v1/targets(3433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(3433)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(3433)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3433)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3433)/publications"},"_namespace":null},{"id":3434,"version":2,"created":1554878146000,"modified":1554878151000,"deprecated":false,"name":"Heterogeneous nuclear ribonucleoprotein A/B","accession":"Q99729","gene":"HNRNPAB","description":"Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1583864102195727,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.456203,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.342446362439766,"pubTatorScore":1.354207739027992,"self":"https://pharos.nih.gov/idg/api/v1/targets(3434)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(3434)/properties"},"_links":{"count":1172,"href":"https://pharos.nih.gov/idg/api/v1/targets(3434)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3434)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(3434)/publications"},"_namespace":null},{"id":3435,"version":2,"created":1554878152000,"modified":1554878154000,"deprecated":false,"name":"Zinc transporter 3","accession":"Q99726","gene":"SLC30A3","description":"Involved in accumulation of zinc in synaptic vesicles.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.0155888140732388,"antibodyCount":67,"monoclonalCount":8,"pubmedCount":null,"jensenScore":111.652963,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.26826937933125,"pubTatorScore":1.4190767425202406,"self":"https://pharos.nih.gov/idg/api/v1/targets(3435)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(3435)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(3435)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3435)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3435)/publications"},"_namespace":null},{"id":3436,"version":2,"created":1554878155000,"modified":1554878158000,"deprecated":false,"name":"Cactin","accession":"Q8WUQ7","gene":"CACTIN","description":"Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2654355370080768,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":19.034576,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.86183341678917,"pubTatorScore":0.6259490180586201,"self":"https://pharos.nih.gov/idg/api/v1/targets(3436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(3436)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(3436)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3436)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3436)/publications"},"_namespace":null},{"id":3437,"version":3,"created":1554878158000,"modified":1555034774000,"deprecated":false,"name":"Metalloproteinase inhibitor 4","accession":"Q99727","gene":"TIMP4","description":"Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0316426881284095,"antibodyCount":400,"monoclonalCount":71,"pubmedCount":null,"jensenScore":109.217328,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.213534566493024,"pubTatorScore":1.9526269777684715,"self":"https://pharos.nih.gov/idg/api/v1/targets(3437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3437)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(3437)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3437)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3437)/publications"},"_namespace":null},{"id":3438,"version":3,"created":1554878162000,"modified":1555034776000,"deprecated":false,"name":"Pleckstrin homology-like domain family A member 1","accession":"Q8WV24","gene":"PHLDA1","description":"Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6807989686849862,"antibodyCount":170,"monoclonalCount":14,"pubmedCount":null,"jensenScore":52.318097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.45584067686524,"pubTatorScore":1.6220474354588346,"self":"https://pharos.nih.gov/idg/api/v1/targets(3438)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(3438)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(3438)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3438)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3438)/publications"},"_namespace":null},{"id":3439,"version":2,"created":1554878165000,"modified":1554878167000,"deprecated":false,"name":"Tandem C2 domains nuclear protein","accession":"Q8N9U0","gene":"TC2N","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.19299201233407398,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.294138,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.760068449686578,"pubTatorScore":0.5517904684669107,"self":"https://pharos.nih.gov/idg/api/v1/targets(3439)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(3439)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(3439)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3439)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3439)/publications"},"_namespace":null},{"id":3440,"version":3,"created":1554878167000,"modified":1555034777000,"deprecated":false,"name":"NADPH oxidase activator 1","accession":"Q86UR1","gene":"NOXA1","description":"Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2442815184900322,"antibodyCount":95,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.949779,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":31.75184195633847,"pubTatorScore":1.2627386967723118,"self":"https://pharos.nih.gov/idg/api/v1/targets(3440)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(3440)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(3440)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3440)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3440)/publications"},"_namespace":null},{"id":3441,"version":2,"created":1554878170000,"modified":1554878170000,"deprecated":false,"name":"Putative uncharacterized protein CXorf42","accession":"Q8N9T2","gene":"NKAPP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.637554265951568,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3441)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3441)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3441)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3441)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3441)/publications"},"_namespace":null},{"id":3442,"version":2,"created":1554878170000,"modified":1554878173000,"deprecated":false,"name":"Protein KRI1 homolog","accession":"Q8N9T8","gene":"KRI1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9807606284064363,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.60606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.806102995738364,"pubTatorScore":0.6172999429090272,"self":"https://pharos.nih.gov/idg/api/v1/targets(3442)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(3442)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(3442)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3442)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3442)/publications"},"_namespace":null},{"id":3443,"version":3,"created":1554878173000,"modified":1555034778000,"deprecated":false,"name":"Tetratricopeptide repeat protein 4","accession":"O95801","gene":"TTC4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9195987625489188,"antibodyCount":62,"monoclonalCount":11,"pubmedCount":null,"jensenScore":8.260145,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.74407283580501,"pubTatorScore":1.0249332364759631,"self":"https://pharos.nih.gov/idg/api/v1/targets(3443)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(3443)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(3443)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3443)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3443)/publications"},"_namespace":null},{"id":3444,"version":2,"created":1554878176000,"modified":1554878178000,"deprecated":false,"name":"Probable G-protein coupled receptor 75","accession":"O95800","gene":"GPR75","description":"G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.6974633389434877,"antibodyCount":271,"monoclonalCount":8,"pubmedCount":null,"jensenScore":4.745039,"patentCount":1953,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.64574784573322,"pubTatorScore":0.40000303750665905,"self":"https://pharos.nih.gov/idg/api/v1/targets(3444)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3444)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(3444)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3444)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3444)/publications"},"_namespace":null},{"id":3445,"version":2,"created":1554878179000,"modified":1554878179000,"deprecated":false,"name":"Putative TAP2-associated 6.5 kDa polypeptide","accession":"Q9Y3F1","gene":null,"description":"May be associated with TAP2 isoform activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3445)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3445)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3445)/links"},"_synonyms":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3445)/synonyms"},"_publications":null,"_namespace":null},{"id":3446,"version":2,"created":1554878179000,"modified":1554878181000,"deprecated":false,"name":"Calcium-binding protein 7","accession":"Q86V35","gene":"CABP7","description":"Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4249982369855762,"antibodyCount":79,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.253763,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.356781136892742,"pubTatorScore":0.7337320571435989,"self":"https://pharos.nih.gov/idg/api/v1/targets(3446)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(3446)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(3446)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3446)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3446)/publications"},"_namespace":null},{"id":3447,"version":3,"created":1554878181000,"modified":1555034779000,"deprecated":false,"name":"Regulating synaptic membrane exocytosis protein 1","accession":"Q86UR5","gene":"RIMS1","description":"Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9571119710009361,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":85.725908,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.42249273868325,"pubTatorScore":1.5940595409876341,"self":"https://pharos.nih.gov/idg/api/v1/targets(3447)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3447)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(3447)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(3447)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3447)/publications"},"_namespace":null},{"id":3448,"version":2,"created":1554878185000,"modified":1554878187000,"deprecated":false,"name":"Zinc finger protein 791","accession":"Q3KP31","gene":"ZNF791","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.78964052995175,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3448)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3448)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(3448)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3448)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3448)/publications"},"_namespace":null},{"id":3449,"version":3,"created":1554878188000,"modified":1555034780000,"deprecated":false,"name":"ATP-sensitive inward rectifier potassium channel 15","accession":"Q99712","gene":"KCNJ15","description":"Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.305415946019588,"antibodyCount":131,"monoclonalCount":29,"pubmedCount":null,"jensenScore":20.986815,"patentCount":2304,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.354795785171284,"pubTatorScore":1.28322936059237,"self":"https://pharos.nih.gov/idg/api/v1/targets(3449)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(3449)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(3449)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3449)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3449)/publications"},"_namespace":null},{"id":3450,"version":3,"created":1554878191000,"modified":1555034782000,"deprecated":false,"name":"Filamin-binding LIM protein 1","accession":"Q8WUP2","gene":"FBLIM1","description":"Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3334220273037696,"antibodyCount":177,"monoclonalCount":82,"pubmedCount":null,"jensenScore":25.879606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":31.749617065296533,"pubTatorScore":1.972546438631726,"self":"https://pharos.nih.gov/idg/api/v1/targets(3450)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(3450)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(3450)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3450)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3450)/publications"},"_namespace":null},{"id":3451,"version":3,"created":1554878194000,"modified":1555034784000,"deprecated":false,"name":"Serine-threonine kinase receptor-associated protein","accession":"Q9Y3F4","gene":"STRAP","description":"The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3590175749019848,"antibodyCount":139,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.85682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":41.58460367209674,"pubTatorScore":2.8053600505204095,"self":"https://pharos.nih.gov/idg/api/v1/targets(3451)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(3451)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3451)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3451)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3451)/publications"},"_namespace":null},{"id":3452,"version":3,"created":1554878198000,"modified":1555034785000,"deprecated":false,"name":"AMP deaminase 3","accession":"Q01432","gene":"AMPD3","description":"AMP deaminase plays a critical role in energy metabolism.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.8582530639065427,"antibodyCount":147,"monoclonalCount":35,"pubmedCount":null,"jensenScore":67.55276,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.22643517589735,"pubTatorScore":2.163360424740059,"self":"https://pharos.nih.gov/idg/api/v1/targets(3452)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(3452)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(3452)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3452)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3452)/publications"},"_namespace":null},{"id":3453,"version":4,"created":1554878211000,"modified":1555034787000,"deprecated":false,"name":"Angiopoietin-1 receptor","accession":"Q02763","gene":"TEK","description":"Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.0025699262025287,"antibodyCount":1009,"monoclonalCount":434,"pubmedCount":null,"jensenScore":906.749236,"patentCount":148559,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.06155631826836,"pubTatorScore":2.8035194904696144,"self":"https://pharos.nih.gov/idg/api/v1/targets(3453)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":700,"href":"https://pharos.nih.gov/idg/api/v1/targets(3453)/properties"},"_links":{"count":1409,"href":"https://pharos.nih.gov/idg/api/v1/targets(3453)/links"},"_synonyms":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(3453)/synonyms"},"_publications":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(3453)/publications"},"_namespace":null},{"id":3454,"version":2,"created":1554878270000,"modified":1554878273000,"deprecated":false,"name":"Mycophenolic acid acyl-glucuronide esterase, mitochondrial","accession":"Q9NUJ1","gene":"ABHD10","description":"Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.43555619281399083,"antibodyCount":33,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.893073,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.245759427170437,"pubTatorScore":0.7403626105316036,"self":"https://pharos.nih.gov/idg/api/v1/targets(3454)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3454)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(3454)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3454)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3454)/publications"},"_namespace":null},{"id":3455,"version":2,"created":1554878274000,"modified":1554878279000,"deprecated":false,"name":"AMP deaminase 2","accession":"Q01433","gene":"AMPD2","description":"AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.7434061153480875,"antibodyCount":155,"monoclonalCount":50,"pubmedCount":null,"jensenScore":53.593917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.36771487771298,"pubTatorScore":1.4020281940242987,"self":"https://pharos.nih.gov/idg/api/v1/targets(3455)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(3455)/properties"},"_links":{"count":1160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3455)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(3455)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3455)/publications"},"_namespace":null},{"id":3456,"version":2,"created":1554878280000,"modified":1554878283000,"deprecated":false,"name":"T-complex protein 11-like protein 1","accession":"Q9NUJ3","gene":"TCP11L1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.7280591108289,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(3456)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(3456)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(3456)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3456)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3456)/publications"},"_namespace":null},{"id":3457,"version":2,"created":1554878284000,"modified":1554878286000,"deprecated":false,"name":"Vesicle transport protein SFT2A","accession":"Q8WV19","gene":"SFT2D1","description":"May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.12493873552256378,"antibodyCount":9,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.066107418973683,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3457)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(3457)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(3457)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3457)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3457)/publications"},"_namespace":null},{"id":3458,"version":3,"created":1554878287000,"modified":1555034790000,"deprecated":false,"name":"Vesicle-trafficking protein SEC22c","accession":"Q9BRL7","gene":"SEC22C","description":"May be involved in vesicle transport between the ER and the Golgi complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.06214790530119616,"antibodyCount":33,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.985714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":28.042555019445615,"pubTatorScore":-0.08354605145007493,"self":"https://pharos.nih.gov/idg/api/v1/targets(3458)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3458)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(3458)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3458)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3458)/publications"},"_namespace":null},{"id":3459,"version":2,"created":1554878289000,"modified":1554878292000,"deprecated":false,"name":"Septin-5","accession":"Q99719","gene":"SEPT5","description":"Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7101663241511134,"antibodyCount":178,"monoclonalCount":33,"pubmedCount":null,"jensenScore":49.431588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.04230148285413,"pubTatorScore":1.9621128462313568,"self":"https://pharos.nih.gov/idg/api/v1/targets(3459)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(3459)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(3459)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3459)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3459)/publications"},"_namespace":null},{"id":3460,"version":2,"created":1554878293000,"modified":1554878293000,"deprecated":false,"name":"Serine/arginine-rich splicing factor 8","accession":"Q9BRL6","gene":"SRSF8","description":"Involved in pre-mRNA alternative splicing.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":98,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.797884743367202,"pubTatorScore":0.4913616938342727,"self":"https://pharos.nih.gov/idg/api/v1/targets(3460)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(3460)/properties"},"_links":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(3460)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3460)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3460)/publications"},"_namespace":null},{"id":3461,"version":3,"created":1554878294000,"modified":1555034792000,"deprecated":false,"name":"Mothers against decapentaplegic homolog 5","accession":"Q99717","gene":"SMAD5","description":"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.160782859070806,"antibodyCount":359,"monoclonalCount":127,"pubmedCount":null,"jensenScore":121.670827,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":44.35139113618447,"pubTatorScore":1.77508476106809,"self":"https://pharos.nih.gov/idg/api/v1/targets(3461)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(3461)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3461)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3461)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3461)/publications"},"_namespace":null},{"id":3462,"version":2,"created":1554878299000,"modified":1554878301000,"deprecated":false,"name":"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3","accession":"O95803","gene":"NDST3","description":"Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6692964419327151,"antibodyCount":111,"monoclonalCount":37,"pubmedCount":null,"jensenScore":5.776812,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.00330591106671,"pubTatorScore":1.2241382630981292,"self":"https://pharos.nih.gov/idg/api/v1/targets(3462)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(3462)/properties"},"_links":{"count":721,"href":"https://pharos.nih.gov/idg/api/v1/targets(3462)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3462)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3462)/publications"},"_namespace":null},{"id":3463,"version":3,"created":1554878301000,"modified":1555034793000,"deprecated":false,"name":"Transmembrane protein 255B","accession":"Q8WV15","gene":"TMEM255B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":17.691312727274553,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3463)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(3463)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(3463)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3463)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3463)/publications"},"_namespace":null},{"id":3464,"version":2,"created":1554878304000,"modified":1554878306000,"deprecated":false,"name":"PI-PLC X domain-containing protein 1","accession":"Q9NUJ7","gene":"PLCXD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2674511041213186,"antibodyCount":108,"monoclonalCount":9,"pubmedCount":null,"jensenScore":1.795833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.717013584163222,"pubTatorScore":-0.17998649074226522,"self":"https://pharos.nih.gov/idg/api/v1/targets(3464)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3464)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(3464)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3464)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3464)/publications"},"_namespace":null},{"id":3465,"version":2,"created":1554878306000,"modified":1554878309000,"deprecated":false,"name":"Collagen alpha-1(XII) chain","accession":"Q99715","gene":"COL12A1","description":"Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.36571261143681,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.447218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.26104642531822,"pubTatorScore":1.4511080075107063,"self":"https://pharos.nih.gov/idg/api/v1/targets(3465)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3465)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(3465)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3465)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3465)/publications"},"_namespace":null},{"id":3466,"version":3,"created":1554878310000,"modified":1555034794000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 4","accession":"Q8WV16","gene":"DCAF4","description":"May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.47952732803227915,"antibodyCount":107,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.183217,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":34.606823322325674,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(3466)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(3466)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(3466)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3466)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3466)/publications"},"_namespace":null},{"id":3467,"version":2,"created":1554878313000,"modified":1554878315000,"deprecated":false,"name":"Transmembrane protein 50A","accession":"O95807","gene":"TMEM50A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3010299956639812,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.466667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.13576100717263,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(3467)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(3467)/properties"},"_links":{"count":847,"href":"https://pharos.nih.gov/idg/api/v1/targets(3467)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3467)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3467)/publications"},"_namespace":null},{"id":3468,"version":3,"created":1554878316000,"modified":1555034796000,"deprecated":false,"name":"3-hydroxyacyl-CoA dehydrogenase type-2","accession":"Q99714","gene":"HSD17B10","description":"In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1346804128715773,"antibodyCount":359,"monoclonalCount":53,"pubmedCount":null,"jensenScore":132.437892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.530356820966766,"pubTatorScore":2.1715732303452864,"self":"https://pharos.nih.gov/idg/api/v1/targets(3468)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(3468)/properties"},"_links":{"count":1183,"href":"https://pharos.nih.gov/idg/api/v1/targets(3468)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3468)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3468)/publications"},"_namespace":null},{"id":3469,"version":2,"created":1554878320000,"modified":1554878323000,"deprecated":false,"name":"Acetoacetyl-CoA synthetase","accession":"Q86V21","gene":"AACS","description":"Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0942753389765,"antibodyCount":97,"monoclonalCount":9,"pubmedCount":null,"jensenScore":127.085557,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.261442362453174,"pubTatorScore":1.1524824489836911,"self":"https://pharos.nih.gov/idg/api/v1/targets(3469)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3469)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(3469)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3469)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3469)/publications"},"_namespace":null},{"id":3470,"version":2,"created":1554878324000,"modified":1554878326000,"deprecated":false,"name":"Protein FAM35A","accession":"Q86V20","gene":"FAM35A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.10187343388197125,"antibodyCount":44,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.962120093065405,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3470)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(3470)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3470)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3470)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3470)/publications"},"_namespace":null},{"id":3471,"version":2,"created":1554878326000,"modified":1554878328000,"deprecated":false,"name":"Zinc finger protein 589","accession":"Q86UQ0","gene":"ZNF589","description":"May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.3960055135273124,"antibodyCount":86,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.411554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.433549360596317,"pubTatorScore":0.15126747095672716,"self":"https://pharos.nih.gov/idg/api/v1/targets(3471)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3471)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(3471)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3471)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3471)/publications"},"_namespace":null},{"id":3472,"version":3,"created":1554878329000,"modified":1555034798000,"deprecated":false,"name":"Cerberus","accession":"O95813","gene":"CER1","description":"Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3233118762348157,"antibodyCount":188,"monoclonalCount":110,"pubmedCount":null,"jensenScore":194.425398,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":21.970689090902695,"pubTatorScore":1.483545206160287,"self":"https://pharos.nih.gov/idg/api/v1/targets(3472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(3472)/properties"},"_links":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(3472)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3472)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3472)/publications"},"_namespace":null},{"id":3473,"version":2,"created":1554878330000,"modified":1554878333000,"deprecated":false,"name":"Caveolae-associated protein 2","accession":"O95810","gene":"CAVIN2","description":"Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.854769398816165,"antibodyCount":84,"monoclonalCount":2,"pubmedCount":null,"jensenScore":685.391373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.2828602819838486,"self":"https://pharos.nih.gov/idg/api/v1/targets(3473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(3473)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(3473)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3473)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(3473)/publications"},"_namespace":null},{"id":3474,"version":2,"created":1554878334000,"modified":1554878336000,"deprecated":false,"name":"Sorting nexin-31","accession":"Q8N9S9","gene":"SNX31","description":"May be involved in protein trafficking.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2718131165369632,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.063853,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.827952789228682,"pubTatorScore":0.2774817720019112,"self":"https://pharos.nih.gov/idg/api/v1/targets(3474)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3474)/properties"},"_links":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(3474)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3474)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3474)/publications"},"_namespace":null},{"id":3475,"version":2,"created":1554878336000,"modified":1554878336000,"deprecated":false,"name":"Transcription factor NF-E4","accession":"Q86UQ8","gene":"NFE4","description":"Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.0530915824217177,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(3475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3475)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3475)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3475)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3475)/publications"},"_namespace":null},{"id":3476,"version":3,"created":1554878336000,"modified":1555034799000,"deprecated":false,"name":"Innate immunity activator protein","accession":"Q3KP66","gene":"INAVA","description":"Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3218909064129703,"antibodyCount":66,"monoclonalCount":7,"pubmedCount":null,"jensenScore":1.757143,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":0.0,"pubTatorScore":-0.11674409563998137,"self":"https://pharos.nih.gov/idg/api/v1/targets(3476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3476)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(3476)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3476)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3476)/publications"},"_namespace":null},{"id":3477,"version":3,"created":1554878339000,"modified":1555034800000,"deprecated":false,"name":"Vasohibin-2","accession":"Q86V25","gene":"VASH2","description":"Angiogenesis inhibitor. Inhibits network formation by endothelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2468033056480432,"antibodyCount":88,"monoclonalCount":1,"pubmedCount":null,"jensenScore":21.888583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.303871839500218,"pubTatorScore":1.0268491672713456,"self":"https://pharos.nih.gov/idg/api/v1/targets(3477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(3477)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(3477)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3477)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3477)/publications"},"_namespace":null},{"id":3478,"version":2,"created":1554878342000,"modified":1554878342000,"deprecated":false,"name":"Gilles de la Tourette syndrome chromosomal region candidate gene 1 protein","accession":"Q86UQ5","gene":"GTSCR1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.5168166592944798,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3478)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3478)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3478)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3478)/publications"},"_namespace":null},{"id":3479,"version":2,"created":1554878342000,"modified":1554878344000,"deprecated":false,"name":"ATP-binding cassette sub-family A member 13","accession":"Q86UQ4","gene":"ABCA13","description":null,"idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.125882469799734,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.940615,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.465751731552846,"pubTatorScore":1.0955567646072186,"self":"https://pharos.nih.gov/idg/api/v1/targets(3479)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3479)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(3479)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3479)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3479)/publications"},"_namespace":null},{"id":3480,"version":3,"created":1554878346000,"modified":1555034801000,"deprecated":false,"name":"Adiponectin receptor protein 2","accession":"Q86V24","gene":"ADIPOR2","description":"Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.244634405450963,"antibodyCount":185,"monoclonalCount":3,"pubmedCount":null,"jensenScore":128.816894,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":45.93210324235468,"pubTatorScore":2.1163019933443197,"self":"https://pharos.nih.gov/idg/api/v1/targets(3480)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(3480)/properties"},"_links":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(3480)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3480)/synonyms"},"_publications":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(3480)/publications"},"_namespace":null},{"id":3481,"version":3,"created":1554878349000,"modified":1555034802000,"deprecated":false,"name":"Ataxin-2","accession":"Q99700","gene":"ATXN2","description":"Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.325227012542872,"antibodyCount":194,"monoclonalCount":1,"pubmedCount":null,"jensenScore":224.632532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":50.49554215244001,"pubTatorScore":2.624533403279489,"self":"https://pharos.nih.gov/idg/api/v1/targets(3481)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":576,"href":"https://pharos.nih.gov/idg/api/v1/targets(3481)/properties"},"_links":{"count":1216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3481)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3481)/synonyms"},"_publications":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(3481)/publications"},"_namespace":null},{"id":3482,"version":2,"created":1554878357000,"modified":1554878359000,"deprecated":false,"name":"Muscleblind-like protein 3","accession":"Q9NUK0","gene":"MBNL3","description":"Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2632602618484516,"antibodyCount":110,"monoclonalCount":3,"pubmedCount":null,"jensenScore":19.804212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.746074206641936,"pubTatorScore":1.079870033469602,"self":"https://pharos.nih.gov/idg/api/v1/targets(3482)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(3482)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(3482)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(3482)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3482)/publications"},"_namespace":null},{"id":3483,"version":2,"created":1554878360000,"modified":1554878364000,"deprecated":false,"name":"DNA endonuclease RBBP8","accession":"Q99708","gene":"RBBP8","description":"Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811, PubMed:10910365, PubMed:15485915, PubMed:16581787, PubMed:16818604, PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:20829486). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.179327051552036,"antibodyCount":308,"monoclonalCount":31,"pubmedCount":null,"jensenScore":148.395199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.34259612665455,"pubTatorScore":2.0368835296229886,"self":"https://pharos.nih.gov/idg/api/v1/targets(3483)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":535,"href":"https://pharos.nih.gov/idg/api/v1/targets(3483)/properties"},"_links":{"count":1175,"href":"https://pharos.nih.gov/idg/api/v1/targets(3483)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(3483)/synonyms"},"_publications":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(3483)/publications"},"_namespace":null},{"id":3484,"version":2,"created":1554878365000,"modified":1554878369000,"deprecated":false,"name":"BAG family molecular chaperone regulator 3","accession":"O95817","gene":"BAG3","description":"Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2633860065151237,"antibodyCount":289,"monoclonalCount":34,"pubmedCount":null,"jensenScore":208.854726,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.59448270791322,"pubTatorScore":2.1691486077859246,"self":"https://pharos.nih.gov/idg/api/v1/targets(3484)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(3484)/properties"},"_links":{"count":1244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3484)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3484)/synonyms"},"_publications":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(3484)/publications"},"_namespace":null},{"id":3485,"version":2,"created":1554878370000,"modified":1554878373000,"deprecated":false,"name":"BAG family molecular chaperone regulator 2","accession":"O95816","gene":"BAG2","description":"Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0055728575914182,"antibodyCount":235,"monoclonalCount":33,"pubmedCount":null,"jensenScore":102.357034,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.30378910751552,"pubTatorScore":1.7314656304840101,"self":"https://pharos.nih.gov/idg/api/v1/targets(3485)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(3485)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(3485)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3485)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3485)/publications"},"_namespace":null},{"id":3486,"version":3,"created":1554878373000,"modified":1555034805000,"deprecated":false,"name":"45 kDa calcium-binding protein","accession":"Q9BRK5","gene":"SDF4","description":"Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.842582522635841,"antibodyCount":193,"monoclonalCount":3,"pubmedCount":null,"jensenScore":535.242264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":39.10599262793459,"pubTatorScore":1.0984514517192334,"self":"https://pharos.nih.gov/idg/api/v1/targets(3486)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(3486)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3486)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3486)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3486)/publications"},"_namespace":null},{"id":3487,"version":3,"created":1554878377000,"modified":1555034808000,"deprecated":false,"name":"Leucine zipper putative tumor suppressor 2","accession":"Q9BRK4","gene":"LZTS2","description":"Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9107133332695586,"antibodyCount":120,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.289244,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":55,"knowledgeAvailability":36.14361949987825,"pubTatorScore":0.8393256090296367,"self":"https://pharos.nih.gov/idg/api/v1/targets(3487)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(3487)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(3487)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3487)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(3487)/publications"},"_namespace":null},{"id":3488,"version":2,"created":1554878380000,"modified":1554878382000,"deprecated":false,"name":"Killer cell immunoglobulin-like receptor 2DL4","accession":"Q99706","gene":"KIR2DL4","description":"Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8766753831910046,"antibodyCount":222,"monoclonalCount":134,"pubmedCount":null,"jensenScore":75.092596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.408272571720378,"pubTatorScore":2.975631523796521,"self":"https://pharos.nih.gov/idg/api/v1/targets(3488)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3488)/properties"},"_links":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(3488)/links"},"_synonyms":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3488)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3488)/publications"},"_namespace":null},{"id":3489,"version":2,"created":1554878383000,"modified":1554878385000,"deprecated":false,"name":"Matrix remodeling-associated protein 8","accession":"Q9BRK3","gene":"MXRA8","description":"May play a role in the maturation and maintenance of blood-brain barrier.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3620908085589003,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.246858,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.156430095706256,"pubTatorScore":0.02802885931724794,"self":"https://pharos.nih.gov/idg/api/v1/targets(3489)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(3489)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(3489)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3489)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3489)/publications"},"_namespace":null},{"id":3490,"version":2,"created":1554878386000,"modified":1554878388000,"deprecated":false,"name":"Oral cancer-overexpressed protein 1","accession":"Q8WV07","gene":"ORAOV1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0685876461646777,"antibodyCount":41,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.314902,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.932884356688135,"pubTatorScore":1.258049989725065,"self":"https://pharos.nih.gov/idg/api/v1/targets(3490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(3490)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(3490)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3490)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3490)/publications"},"_namespace":null},{"id":3491,"version":2,"created":1554878388000,"modified":1554878394000,"deprecated":false,"name":"Methionine synthase","accession":"Q99707","gene":"MTR","description":"Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.5689950791224954,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":300.227958,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.589371967233866,"pubTatorScore":2.186064685043962,"self":"https://pharos.nih.gov/idg/api/v1/targets(3491)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(3491)/properties"},"_links":{"count":1233,"href":"https://pharos.nih.gov/idg/api/v1/targets(3491)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3491)/synonyms"},"_publications":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(3491)/publications"},"_namespace":null},{"id":3492,"version":3,"created":1554878395000,"modified":1555034809000,"deprecated":false,"name":"Docking protein 1","accession":"Q99704","gene":"DOK1","description":"DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6504578958314122,"antibodyCount":676,"monoclonalCount":6,"pubmedCount":null,"jensenScore":43.378126,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.28011662980863,"pubTatorScore":1.739560937148314,"self":"https://pharos.nih.gov/idg/api/v1/targets(3492)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(3492)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(3492)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3492)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3492)/publications"},"_namespace":null},{"id":3493,"version":4,"created":1554878399000,"modified":1555034810000,"deprecated":false,"name":"Melanin-concentrating hormone receptor 1","accession":"Q99705","gene":"MCHR1","description":"Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.4706620585457797,"antibodyCount":225,"monoclonalCount":29,"pubmedCount":null,"jensenScore":311.52298,"patentCount":20907,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.692958433066277,"pubTatorScore":2.195795353886472,"self":"https://pharos.nih.gov/idg/api/v1/targets(3493)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3493)/properties"},"_links":{"count":2828,"href":"https://pharos.nih.gov/idg/api/v1/targets(3493)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3493)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3493)/publications"},"_namespace":null},{"id":3494,"version":2,"created":1554879158000,"modified":1554879168000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase kinase 4","accession":"O95819","gene":"MAP4K4","description":"Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.1906409825147874,"antibodyCount":547,"monoclonalCount":143,"pubmedCount":null,"jensenScore":152.557161,"patentCount":49874,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.15272951485809,"pubTatorScore":1.717404520196118,"self":"https://pharos.nih.gov/idg/api/v1/targets(3494)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(3494)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(3494)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(3494)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3494)/publications"},"_namespace":null},{"id":3495,"version":2,"created":1554879170000,"modified":1554879172000,"deprecated":false,"name":"Cadherin-24","accession":"Q86UP0","gene":"CDH24","description":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.01848340533210112,"antibodyCount":83,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.019039,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.011012343424415,"pubTatorScore":0.24303804868629444,"self":"https://pharos.nih.gov/idg/api/v1/targets(3495)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(3495)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(3495)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3495)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3495)/publications"},"_namespace":null},{"id":3496,"version":2,"created":1554879172000,"modified":1554879172000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC00304","accession":"Q8N9R0","gene":"LINC00304","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.266116054253469,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3496)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3496)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3496)/links"},"_synonyms":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3496)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3496)/publications"},"_namespace":null},{"id":3497,"version":2,"created":1554879172000,"modified":1554879174000,"deprecated":false,"name":"CMT1A duplicated region transcript 4 protein","accession":"Q8N9R6","gene":"CDRT4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.709144866573055,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3497)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(3497)/properties"},"_links":{"count":809,"href":"https://pharos.nih.gov/idg/api/v1/targets(3497)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3497)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3497)/publications"},"_namespace":null},{"id":3498,"version":3,"created":1554879174000,"modified":1555034816000,"deprecated":false,"name":"Receptor expression-enhancing protein 2","accession":"Q9BRK0","gene":"REEP2","description":"Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3771847866471237,"antibodyCount":159,"monoclonalCount":82,"pubmedCount":null,"jensenScore":2.370833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.453958517740915,"pubTatorScore":0.5475011244386945,"self":"https://pharos.nih.gov/idg/api/v1/targets(3498)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(3498)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(3498)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3498)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3498)/publications"},"_namespace":null},{"id":3499,"version":3,"created":1554879177000,"modified":1554879257000,"deprecated":false,"name":"Malonyl-CoA decarboxylase, mitochondrial","accession":"O95822","gene":"MLYCD","description":"Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.7043381352270772,"antibodyCount":67,"monoclonalCount":3,"pubmedCount":null,"jensenScore":46.065721,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.30546408319903,"pubTatorScore":1.857700067626686,"self":"https://pharos.nih.gov/idg/api/v1/targets(3499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3499)/properties"},"_links":{"count":1239,"href":"https://pharos.nih.gov/idg/api/v1/targets(3499)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3499)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3499)/publications"},"_namespace":null},{"id":3500,"version":3,"created":1554879258000,"modified":1555034818000,"deprecated":false,"name":"Aryl hydrocarbon receptor nuclear translocator 2","accession":"Q9HBZ2","gene":"ARNT2","description":"Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6858752308395224,"antibodyCount":212,"monoclonalCount":24,"pubmedCount":null,"jensenScore":54.13146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.61286749414449,"pubTatorScore":1.3929759549702432,"self":"https://pharos.nih.gov/idg/api/v1/targets(3500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(3500)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(3500)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3500)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3500)/publications"},"_namespace":null},{"id":3501,"version":2,"created":1554879262000,"modified":1554879264000,"deprecated":false,"name":"LHFPL tetraspan subfamily member 3 protein","accession":"Q86UP9","gene":"LHFPL3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4238957217743667,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.310812,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.97198295702808,"pubTatorScore":0.07310734300831032,"self":"https://pharos.nih.gov/idg/api/v1/targets(3501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(3501)/properties"},"_links":{"count":674,"href":"https://pharos.nih.gov/idg/api/v1/targets(3501)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3501)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3501)/publications"},"_namespace":null},{"id":3502,"version":2,"created":1554879265000,"modified":1554879267000,"deprecated":false,"name":"General transcription factor II-I repeat domain-containing protein 2A","accession":"Q86UP8","gene":"GTF2IRD2","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.4548448637000133,"antibodyCount":58,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.018008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.29950652552005,"pubTatorScore":1.025988154680467,"self":"https://pharos.nih.gov/idg/api/v1/targets(3502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(3502)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(3502)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3502)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3502)/publications"},"_namespace":null},{"id":3503,"version":2,"created":1554879267000,"modified":1554879270000,"deprecated":false,"name":"Protein SCAI","accession":"Q8N9R8","gene":"SCAI","description":"Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4954027415441105,"antibodyCount":22,"monoclonalCount":6,"pubmedCount":null,"jensenScore":300.349079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.95806173158434,"pubTatorScore":2.331078461523941,"self":"https://pharos.nih.gov/idg/api/v1/targets(3503)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3503)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(3503)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3503)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3503)/publications"},"_namespace":null},{"id":3504,"version":2,"created":1554879271000,"modified":1554879273000,"deprecated":false,"name":"CUB and zona pellucida-like domain-containing protein 1","accession":"Q86UP6","gene":"CUZD1","description":"CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1041293010785234,"antibodyCount":95,"monoclonalCount":15,"pubmedCount":null,"jensenScore":12.731283,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.723356482744734,"pubTatorScore":1.1069271111313397,"self":"https://pharos.nih.gov/idg/api/v1/targets(3504)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3504)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(3504)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3504)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3504)/publications"},"_namespace":null},{"id":3505,"version":3,"created":1554879273000,"modified":1554879360000,"deprecated":false,"name":"Dual specificity mitogen-activated protein kinase kinase 1","accession":"Q02750","gene":"MAP2K1","description":"Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.0719679192516174,"antibodyCount":2448,"monoclonalCount":721,"pubmedCount":null,"jensenScore":862.429491,"patentCount":54927,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":60.004703666643486,"pubTatorScore":2.7447517375803443,"self":"https://pharos.nih.gov/idg/api/v1/targets(3505)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1055,"href":"https://pharos.nih.gov/idg/api/v1/targets(3505)/properties"},"_links":{"count":1743,"href":"https://pharos.nih.gov/idg/api/v1/targets(3505)/links"},"_synonyms":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3505)/synonyms"},"_publications":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(3505)/publications"},"_namespace":null},{"id":3506,"version":2,"created":1554879363000,"modified":1554879366000,"deprecated":false,"name":"Zinc finger protein castor homolog 1","accession":"Q86V15","gene":"CASZ1","description":"Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.021750987757357,"antibodyCount":137,"monoclonalCount":0,"pubmedCount":null,"jensenScore":103.197737,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.294336857691846,"pubTatorScore":1.3591141824222108,"self":"https://pharos.nih.gov/idg/api/v1/targets(3506)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(3506)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(3506)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3506)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3506)/publications"},"_namespace":null},{"id":3507,"version":2,"created":1554879366000,"modified":1554879369000,"deprecated":false,"name":"Zinc finger homeobox protein 4","accession":"Q86UP3","gene":"ZFHX4","description":"May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.8606907795566858,"antibodyCount":40,"monoclonalCount":22,"pubmedCount":null,"jensenScore":8.150628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.41372890814866,"pubTatorScore":0.919103730691111,"self":"https://pharos.nih.gov/idg/api/v1/targets(3507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(3507)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(3507)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3507)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3507)/publications"},"_namespace":null},{"id":3508,"version":2,"created":1554879369000,"modified":1554879374000,"deprecated":false,"name":"Kinectin","accession":"Q86UP2","gene":"KTN1","description":"Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9341093327288634,"antibodyCount":89,"monoclonalCount":1,"pubmedCount":null,"jensenScore":83.393016,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.224109805364115,"pubTatorScore":1.6596106229661862,"self":"https://pharos.nih.gov/idg/api/v1/targets(3508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(3508)/properties"},"_links":{"count":1247,"href":"https://pharos.nih.gov/idg/api/v1/targets(3508)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3508)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(3508)/publications"},"_namespace":null},{"id":3509,"version":3,"created":1554879375000,"modified":1555034820000,"deprecated":false,"name":"N-acetylgalactosamine kinase","accession":"Q01415","gene":"GALK2","description":"Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.258665815158465,"antibodyCount":203,"monoclonalCount":2,"pubmedCount":null,"jensenScore":17.151983,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":35.881358779311505,"pubTatorScore":0.861832997657945,"self":"https://pharos.nih.gov/idg/api/v1/targets(3509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3509)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(3509)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3509)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3509)/publications"},"_namespace":null},{"id":3510,"version":2,"created":1554879378000,"modified":1554879379000,"deprecated":false,"name":"Guanylin","accession":"Q02747","gene":"GUCA2A","description":"Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9266692058743817,"antibodyCount":137,"monoclonalCount":12,"pubmedCount":null,"jensenScore":79.243108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.663966535502844,"pubTatorScore":1.4532818975409734,"self":"https://pharos.nih.gov/idg/api/v1/targets(3510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(3510)/properties"},"_links":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(3510)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3510)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3510)/publications"},"_namespace":null},{"id":3511,"version":2,"created":1554879380000,"modified":1554879382000,"deprecated":false,"name":"Double-stranded RNA-binding protein Staufen homolog 2","accession":"Q9NUL3","gene":"STAU2","description":"RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2600998039340463,"antibodyCount":176,"monoclonalCount":97,"pubmedCount":null,"jensenScore":21.631503,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.77903124462342,"pubTatorScore":0.9616092950216055,"self":"https://pharos.nih.gov/idg/api/v1/targets(3511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(3511)/properties"},"_links":{"count":1193,"href":"https://pharos.nih.gov/idg/api/v1/targets(3511)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3511)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3511)/publications"},"_namespace":null},{"id":3512,"version":3,"created":1554879383000,"modified":1555034821000,"deprecated":false,"name":"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase","accession":"Q02742","gene":"GCNT1","description":"Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.964166175737205,"antibodyCount":191,"monoclonalCount":2,"pubmedCount":null,"jensenScore":93.323924,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":39.71200846112413,"pubTatorScore":1.8686699311440715,"self":"https://pharos.nih.gov/idg/api/v1/targets(3512)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(3512)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(3512)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3512)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(3512)/publications"},"_namespace":null},{"id":3513,"version":3,"created":1554879387000,"modified":1555034823000,"deprecated":false,"name":"Repressor of yield of DENV protein","accession":"Q9NUL5","gene":"C19orf66","description":"Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.1995723530956438,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.833333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3513)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3513)/publications"},"_namespace":null},{"id":3514,"version":3,"created":1554879392000,"modified":1555034824000,"deprecated":false,"name":"Ubiquitin domain-containing protein 2","accession":"Q8WUN7","gene":"UBTD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6577461741086896,"antibodyCount":116,"monoclonalCount":32,"pubmedCount":null,"jensenScore":5.036663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":24.192754741755248,"pubTatorScore":0.7436404253784553,"self":"https://pharos.nih.gov/idg/api/v1/targets(3514)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3514)/publications"},"_namespace":null},{"id":3515,"version":3,"created":1554879394000,"modified":1555034825000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX28","accession":"Q9NUL7","gene":"DDX28","description":"Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6180480884604976,"antibodyCount":109,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.540909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":32.33689096251899,"pubTatorScore":0.6483600109809317,"self":"https://pharos.nih.gov/idg/api/v1/targets(3515)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3515)/publications"},"_namespace":null},{"id":3516,"version":2,"created":1554879397000,"modified":1554879398000,"deprecated":false,"name":"39S ribosomal protein L45, mitochondrial","accession":"Q9BRJ2","gene":"MRPL45","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5093059379876602,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.233334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.603086016213666,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3516)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/properties"},"_links":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3516)/publications"},"_namespace":null},{"id":3517,"version":2,"created":1554879398000,"modified":1554879401000,"deprecated":false,"name":"Quinone oxidoreductase-like protein 1","accession":"O95825","gene":"CRYZL1","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3795069704868077,"antibodyCount":157,"monoclonalCount":43,"pubmedCount":null,"jensenScore":20.513476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.41619385074886,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3517)/publications"},"_namespace":null},{"id":3518,"version":3,"created":1554879402000,"modified":1555034826000,"deprecated":false,"name":"Serine/threonine-protein kinase Sgk2","accession":"Q9HBY8","gene":"SGK2","description":"Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.806718193228615,"antibodyCount":223,"monoclonalCount":71,"pubmedCount":null,"jensenScore":4.282946,"patentCount":4248,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.09585466253001,"pubTatorScore":0.8916576943257375,"self":"https://pharos.nih.gov/idg/api/v1/targets(3518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3518)/publications"},"_namespace":null},{"id":3519,"version":2,"created":1554879407000,"modified":1554879410000,"deprecated":false,"name":"Mesoderm posterior protein 1","accession":"Q9BRJ9","gene":"MESP1","description":"Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3853552119220134,"antibodyCount":208,"monoclonalCount":78,"pubmedCount":null,"jensenScore":26.770514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.693983707041177,"pubTatorScore":1.4024085876333938,"self":"https://pharos.nih.gov/idg/api/v1/targets(3519)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/properties"},"_links":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3519)/publications"},"_namespace":null},{"id":3520,"version":3,"created":1554879411000,"modified":1555034828000,"deprecated":false,"name":"Tudor-interacting repair regulator protein","accession":"Q9BRJ7","gene":"NUDT16L1","description":"Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.544068022635552,"antibodyCount":44,"monoclonalCount":5,"pubmedCount":null,"jensenScore":33.522222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.671377373198197,"pubTatorScore":0.8750612633917001,"self":"https://pharos.nih.gov/idg/api/v1/targets(3520)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3520)/publications"},"_namespace":null},{"id":3521,"version":2,"created":1554879413000,"modified":1554879416000,"deprecated":false,"name":"Uncharacterized protein C7orf50","accession":"Q9BRJ6","gene":"C7orf50","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":87,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3521)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/properties"},"_links":{"count":1068,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3521)/publications"},"_namespace":null},{"id":3522,"version":2,"created":1554879416000,"modified":1554879419000,"deprecated":false,"name":"Arfaptin-1","accession":"P53367","gene":"ARFIP1","description":"Putative target protein of ADP-ribosylation factor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4425793046961826,"antibodyCount":199,"monoclonalCount":9,"pubmedCount":null,"jensenScore":4.762154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.58310895663183,"pubTatorScore":0.46311055451601085,"self":"https://pharos.nih.gov/idg/api/v1/targets(3522)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3522)/publications"},"_namespace":null},{"id":3523,"version":3,"created":1554879420000,"modified":1555034829000,"deprecated":false,"name":"Voltage-gated potassium channel subunit beta-1","accession":"Q14722","gene":"KCNAB1","description":"Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.734411045181535,"antibodyCount":218,"monoclonalCount":110,"pubmedCount":null,"jensenScore":56.324767,"patentCount":1214,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.080588141065846,"pubTatorScore":1.5230690895767955,"self":"https://pharos.nih.gov/idg/api/v1/targets(3523)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(3523)/publications"},"_namespace":null},{"id":3524,"version":3,"created":1554879423000,"modified":1555034830000,"deprecated":false,"name":"Apoptosis-inducing factor 1, mitochondrial","accession":"O95831","gene":"AIFM1","description":"Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7407220430914006,"antibodyCount":637,"monoclonalCount":73,"pubmedCount":null,"jensenScore":50.522812,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":49.17161229799191,"pubTatorScore":2.0515900283762103,"self":"https://pharos.nih.gov/idg/api/v1/targets(3524)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/properties"},"_links":{"count":1284,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/synonyms"},"_publications":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(3524)/publications"},"_namespace":null},{"id":3525,"version":2,"created":1554879432000,"modified":1554879432000,"deprecated":false,"name":"Zinc finger CCHC domain-containing protein 3","accession":"Q9NUD5","gene":"ZCCHC3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":38,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.416584638987157,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3525)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/properties"},"_links":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3525)/publications"},"_namespace":null},{"id":3526,"version":2,"created":1554879432000,"modified":1554879440000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily B member 1","accession":"Q14721","gene":"KCNB1","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.574839263760118,"antibodyCount":303,"monoclonalCount":77,"pubmedCount":null,"jensenScore":386.036388,"patentCount":4428,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.733890383717345,"pubTatorScore":2.331585939915935,"self":"https://pharos.nih.gov/idg/api/v1/targets(3526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3526)/publications"},"_namespace":null},{"id":3527,"version":3,"created":1554879441000,"modified":1555034832000,"deprecated":false,"name":"Uncharacterized protein C20orf96","accession":"Q9NUD7","gene":"C20orf96","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/properties"},"_links":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3527)/publications"},"_namespace":null},{"id":3528,"version":3,"created":1554879444000,"modified":1555034833000,"deprecated":false,"name":"Arfaptin-2","accession":"P53365","gene":"ARFIP2","description":"Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0788277005657503,"antibodyCount":194,"monoclonalCount":31,"pubmedCount":null,"jensenScore":109.531852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.69429934837589,"pubTatorScore":1.987747968942807,"self":"https://pharos.nih.gov/idg/api/v1/targets(3528)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(3528)/properties"},"_links":{"count":1135,"href":"https://pharos.nih.gov/idg/api/v1/targets(3528)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3528)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3528)/publications"},"_namespace":null},{"id":3529,"version":3,"created":1554879447000,"modified":1555034835000,"deprecated":false,"name":"Cancer/testis antigen 55","accession":"Q8WUE5","gene":"CT55","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5086900042955068,"antibodyCount":20,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.513081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":10.30157700859421,"pubTatorScore":0.3521825181113625,"self":"https://pharos.nih.gov/idg/api/v1/targets(3529)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3529)/properties"},"_links":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(3529)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3529)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3529)/publications"},"_namespace":null},{"id":3530,"version":2,"created":1554879449000,"modified":1554879451000,"deprecated":false,"name":"GPI mannosyltransferase 2","accession":"Q9NUD9","gene":"PIGV","description":"Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0756483375556654,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":13.437273,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.56381921241492,"pubTatorScore":1.0585796327577213,"self":"https://pharos.nih.gov/idg/api/v1/targets(3530)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(3530)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(3530)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3530)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3530)/publications"},"_namespace":null},{"id":3531,"version":3,"created":1554879452000,"modified":1555034835000,"deprecated":false,"name":"Serine/threonine-protein kinase LATS1","accession":"O95835","gene":"LATS1","description":"Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.3174921097669308,"antibodyCount":253,"monoclonalCount":24,"pubmedCount":null,"jensenScore":178.975868,"patentCount":7672,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":41.99718724671408,"pubTatorScore":1.8291501984540637,"self":"https://pharos.nih.gov/idg/api/v1/targets(3531)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":507,"href":"https://pharos.nih.gov/idg/api/v1/targets(3531)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(3531)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3531)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3531)/publications"},"_namespace":null},{"id":3532,"version":2,"created":1554879456000,"modified":1554879459000,"deprecated":false,"name":"Echinoderm microtubule-associated protein-like 2","accession":"O95834","gene":"EML2","description":"Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.804561276197967,"antibodyCount":93,"monoclonalCount":18,"pubmedCount":null,"jensenScore":4.274523,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.215154078775683,"pubTatorScore":0.5210134023622424,"self":"https://pharos.nih.gov/idg/api/v1/targets(3532)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(3532)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(3532)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3532)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3532)/publications"},"_namespace":null},{"id":3533,"version":2,"created":1554879459000,"modified":1554879462000,"deprecated":false,"name":"Chloride intracellular channel protein 3","accession":"O95833","gene":"CLIC3","description":"Can insert into membranes and form chloride ion channels. May participate in cellular growth control.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.0199565660297252,"antibodyCount":180,"monoclonalCount":50,"pubmedCount":null,"jensenScore":11.145254,"patentCount":1108,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.18874786248198,"pubTatorScore":0.9772195770386505,"self":"https://pharos.nih.gov/idg/api/v1/targets(3533)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(3533)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(3533)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3533)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3533)/publications"},"_namespace":null},{"id":3534,"version":2,"created":1554879462000,"modified":1554879468000,"deprecated":false,"name":"Claudin-1","accession":"O95832","gene":"CLDN1","description":"(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010). Acts as a receptor for dengue virus (PubMed:24074594).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.076256156720675,"antibodyCount":593,"monoclonalCount":93,"pubmedCount":null,"jensenScore":126.721103,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.339694194033605,"pubTatorScore":2.6237059993169463,"self":"https://pharos.nih.gov/idg/api/v1/targets(3534)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":545,"href":"https://pharos.nih.gov/idg/api/v1/targets(3534)/properties"},"_links":{"count":1156,"href":"https://pharos.nih.gov/idg/api/v1/targets(3534)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3534)/synonyms"},"_publications":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(3534)/publications"},"_namespace":null},{"id":3535,"version":2,"created":1554879469000,"modified":1554879472000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 10","accession":"Q14728","gene":"MFSD10","description":"Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.175259946971259,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":146.277832,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.4369964338956,"pubTatorScore":0.27151378791666075,"self":"https://pharos.nih.gov/idg/api/v1/targets(3535)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3535)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(3535)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3535)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3535)/publications"},"_namespace":null},{"id":3536,"version":2,"created":1554879472000,"modified":1554879475000,"deprecated":false,"name":"Synaptotagmin-2","accession":"Q8N9I0","gene":"SYT2","description":"Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9350252832300694,"antibodyCount":222,"monoclonalCount":28,"pubmedCount":null,"jensenScore":86.71147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.31116319783467,"pubTatorScore":1.624841603783151,"self":"https://pharos.nih.gov/idg/api/v1/targets(3536)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(3536)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(3536)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3536)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3536)/publications"},"_namespace":null},{"id":3537,"version":2,"created":1554879476000,"modified":1554879477000,"deprecated":false,"name":"Fatty acid desaturase 6","accession":"Q8N9I5","gene":"FADS6","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.181818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.542809787496273,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3537)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3537)/properties"},"_links":{"count":659,"href":"https://pharos.nih.gov/idg/api/v1/targets(3537)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3537)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3537)/publications"},"_namespace":null},{"id":3538,"version":2,"created":1554879477000,"modified":1554879479000,"deprecated":false,"name":"Outer dense fiber protein 3B","accession":"A8MYP8","gene":"ODF3B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.10914447087271632,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.631944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.616770103192792,"pubTatorScore":-0.6146493741034004,"self":"https://pharos.nih.gov/idg/api/v1/targets(3538)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(3538)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(3538)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3538)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3538)/publications"},"_namespace":null},{"id":3539,"version":3,"created":1554879480000,"modified":1555034838000,"deprecated":false,"name":"Ribosomal RNA-processing protein 7 homolog A","accession":"Q9Y3A4","gene":"RRP7A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.285714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":30.04651445306472,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3539)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(3539)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(3539)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3539)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3539)/publications"},"_namespace":null},{"id":3540,"version":2,"created":1554879483000,"modified":1554879485000,"deprecated":false,"name":"Exonuclease mut-7 homolog","accession":"Q8N9H8","gene":"EXD3","description":"Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.45611287077412827,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.910208,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(3540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(3540)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(3540)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3540)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3540)/publications"},"_namespace":null},{"id":3541,"version":2,"created":1554879485000,"modified":1554879488000,"deprecated":false,"name":"MOB-like protein phocein","accession":"Q9Y3A3","gene":"MOB4","description":"May play a role in membrane trafficking, specifically in membrane budding reactions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3645870328680474,"antibodyCount":114,"monoclonalCount":5,"pubmedCount":null,"jensenScore":24.732602,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.13864679381049,"pubTatorScore":0.8212638847256145,"self":"https://pharos.nih.gov/idg/api/v1/targets(3541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(3541)/properties"},"_links":{"count":1156,"href":"https://pharos.nih.gov/idg/api/v1/targets(3541)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3541)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3541)/publications"},"_namespace":null},{"id":3542,"version":3,"created":1554879489000,"modified":1555034839000,"deprecated":false,"name":"Uncharacterized protein C1orf127","accession":"Q8N9H9","gene":"C1orf127","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3542)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3542)/properties"},"_links":{"count":688,"href":"https://pharos.nih.gov/idg/api/v1/targets(3542)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3542)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3542)/publications"},"_namespace":null},{"id":3543,"version":2,"created":1554879491000,"modified":1554879491000,"deprecated":false,"name":"Uncharacterized protein C8orf31","accession":"Q8N9H6","gene":"C8orf31","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3543)/properties"},"_links":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3543)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3543)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3543)/publications"},"_namespace":null},{"id":3544,"version":2,"created":1554879491000,"modified":1554879493000,"deprecated":false,"name":"Transmembrane emp24 domain-containing protein 5","accession":"Q9Y3A6","gene":"TMED5","description":"Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2710667688121821,"antibodyCount":29,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.666666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.828650676677015,"pubTatorScore":0.8113195817028793,"self":"https://pharos.nih.gov/idg/api/v1/targets(3544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(3544)/properties"},"_links":{"count":1061,"href":"https://pharos.nih.gov/idg/api/v1/targets(3544)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3544)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3544)/publications"},"_namespace":null},{"id":3545,"version":2,"created":1554879494000,"modified":1554879496000,"deprecated":false,"name":"Thioredoxin domain-containing protein 17","accession":"Q9BRA2","gene":"TXNDC17","description":"Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6689328413793345,"antibodyCount":59,"monoclonalCount":8,"pubmedCount":null,"jensenScore":45.147018,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.0366524078238,"pubTatorScore":1.5502190676174714,"self":"https://pharos.nih.gov/idg/api/v1/targets(3545)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(3545)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(3545)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3545)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3545)/publications"},"_namespace":null},{"id":3546,"version":2,"created":1554879497000,"modified":1554879500000,"deprecated":false,"name":"Ribosome maturation protein SBDS","accession":"Q9Y3A5","gene":"SBDS","description":"Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2423307249931224,"antibodyCount":139,"monoclonalCount":40,"pubmedCount":null,"jensenScore":174.412314,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.3226680646864,"pubTatorScore":2.069824459164832,"self":"https://pharos.nih.gov/idg/api/v1/targets(3546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(3546)/properties"},"_links":{"count":1168,"href":"https://pharos.nih.gov/idg/api/v1/targets(3546)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3546)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3546)/publications"},"_namespace":null},{"id":3547,"version":2,"created":1554879501000,"modified":1554879504000,"deprecated":false,"name":"Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial","accession":"Q9Y3A0","gene":"COQ4","description":"Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1716103651004228,"antibodyCount":26,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.000697,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.10613873351833,"pubTatorScore":0.8094527774959135,"self":"https://pharos.nih.gov/idg/api/v1/targets(3547)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(3547)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(3547)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3547)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3547)/publications"},"_namespace":null},{"id":3548,"version":3,"created":1554879505000,"modified":1555034840000,"deprecated":false,"name":"Solute carrier organic anion transporter family member 6A1","accession":"Q86UG4","gene":"SLCO6A1","description":null,"idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.2320486563328465,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.548128,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":19.045050137117325,"pubTatorScore":0.5897810981079465,"self":"https://pharos.nih.gov/idg/api/v1/targets(3548)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3548)/properties"},"_links":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(3548)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3548)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3548)/publications"},"_namespace":null},{"id":3549,"version":2,"created":1554879506000,"modified":1554879512000,"deprecated":false,"name":"DNA dC->dU-editing enzyme APOBEC-3G","accession":"Q9HC16","gene":"APOBEC3G","description":"DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7851005446336705,"antibodyCount":477,"monoclonalCount":60,"pubmedCount":null,"jensenScore":662.155954,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.18122517003812,"pubTatorScore":2.7313361023270923,"self":"https://pharos.nih.gov/idg/api/v1/targets(3549)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":681,"href":"https://pharos.nih.gov/idg/api/v1/targets(3549)/properties"},"_links":{"count":1279,"href":"https://pharos.nih.gov/idg/api/v1/targets(3549)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3549)/synonyms"},"_publications":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(3549)/publications"},"_namespace":null},{"id":3550,"version":3,"created":1554879514000,"modified":1555034841000,"deprecated":false,"name":"Probable U3 small nucleolar RNA-associated protein 11","accession":"Q9Y3A2","gene":"UTP11","description":"Involved in nucleolar processing of pre-18S ribosomal RNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5390942829096996,"antibodyCount":84,"monoclonalCount":14,"pubmedCount":null,"jensenScore":3.375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":0.48467445251279134,"self":"https://pharos.nih.gov/idg/api/v1/targets(3550)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3550)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(3550)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3550)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3550)/publications"},"_namespace":null},{"id":3551,"version":3,"created":1554879516000,"modified":1555034842000,"deprecated":false,"name":"Nucleoside diphosphate-linked moiety X motif 6","accession":"P53370","gene":"NUDT6","description":"May contribute to the regulation of cell proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7130058231493683,"antibodyCount":157,"monoclonalCount":69,"pubmedCount":null,"jensenScore":46.139537,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":32.628629894700275,"pubTatorScore":1.0381291675019895,"self":"https://pharos.nih.gov/idg/api/v1/targets(3551)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3551)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(3551)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3551)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3551)/publications"},"_namespace":null},{"id":3552,"version":3,"created":1554879519000,"modified":1555034843000,"deprecated":false,"name":"Glucagon-like peptide 2 receptor","accession":"O95838","gene":"GLP2R","description":"This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-1.4585535606466344,"antibodyCount":221,"monoclonalCount":43,"pubmedCount":null,"jensenScore":24.511405,"patentCount":3733,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.920996393640895,"pubTatorScore":1.474729768639322,"self":"https://pharos.nih.gov/idg/api/v1/targets(3552)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(3552)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(3552)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3552)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3552)/publications"},"_namespace":null},{"id":3553,"version":2,"created":1554879587000,"modified":1554879592000,"deprecated":false,"name":"Collagen alpha-1(XVIII) chain","accession":"P39060","gene":"COL18A1","description":"Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.183394178274487,"antibodyCount":433,"monoclonalCount":109,"pubmedCount":null,"jensenScore":1561.428133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.05657736462447,"pubTatorScore":2.91378824996937,"self":"https://pharos.nih.gov/idg/api/v1/targets(3553)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":602,"href":"https://pharos.nih.gov/idg/api/v1/targets(3553)/properties"},"_links":{"count":1244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3553)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(3553)/synonyms"},"_publications":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(3553)/publications"},"_namespace":null},{"id":3554,"version":2,"created":1554879593000,"modified":1554879595000,"deprecated":false,"name":"Palmitoyltransferase ZDHHC18","accession":"Q9NUE0","gene":"ZDHHC18","description":"Has palmitoyltransferase activity towards HRAS and LCK.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.38021124171160603,"antibodyCount":61,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.253968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.625608735620986,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3554)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(3554)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(3554)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3554)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3554)/publications"},"_namespace":null},{"id":3555,"version":3,"created":1554879596000,"modified":1555034846000,"deprecated":false,"name":"GPN-loop GTPase 3","accession":"Q9UHW5","gene":"GPN3","description":"Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4648868019217715,"antibodyCount":35,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.814286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":32.97866379101892,"pubTatorScore":0.425968786559088,"self":"https://pharos.nih.gov/idg/api/v1/targets(3555)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(3555)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(3555)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3555)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3555)/publications"},"_namespace":null},{"id":3556,"version":2,"created":1554879598000,"modified":1554879601000,"deprecated":false,"name":"Guanine nucleotide-binding protein subunit alpha-14","accession":"O95837","gene":"GNA14","description":"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7860919783694967,"antibodyCount":142,"monoclonalCount":11,"pubmedCount":null,"jensenScore":4.511345,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.59011096688686,"pubTatorScore":1.1066845967572596,"self":"https://pharos.nih.gov/idg/api/v1/targets(3556)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(3556)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(3556)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3556)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3556)/publications"},"_namespace":null},{"id":3557,"version":2,"created":1554879602000,"modified":1554879603000,"deprecated":false,"name":"Pejvakin","accession":"Q0ZLH3","gene":"PJVK","description":"Essential in the activity of auditory pathway neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.158733343311791,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.159777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.2613949931997916,"self":"https://pharos.nih.gov/idg/api/v1/targets(3557)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(3557)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(3557)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3557)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3557)/publications"},"_namespace":null},{"id":3558,"version":3,"created":1554879604000,"modified":1555034848000,"deprecated":false,"name":"N-alpha-acetyltransferase 38, NatC auxiliary subunit","accession":"Q9BRA0","gene":"NAA38","description":"Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.3224654235585563,"antibodyCount":32,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.02193,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":35.879354784212,"pubTatorScore":-0.5399113897085027,"self":"https://pharos.nih.gov/idg/api/v1/targets(3558)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3558)/properties"},"_links":{"count":853,"href":"https://pharos.nih.gov/idg/api/v1/targets(3558)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3558)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3558)/publications"},"_namespace":null},{"id":3559,"version":2,"created":1554879606000,"modified":1554879628000,"deprecated":false,"name":"Fatty acid-binding protein, adipocyte","accession":"P15090","gene":"FABP4","description":"Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.7393539101806335,"antibodyCount":605,"monoclonalCount":142,"pubmedCount":null,"jensenScore":617.654491,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.55998422263732,"pubTatorScore":2.606901304139615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3559)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(3559)/properties"},"_links":{"count":1147,"href":"https://pharos.nih.gov/idg/api/v1/targets(3559)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(3559)/synonyms"},"_publications":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(3559)/publications"},"_namespace":null},{"id":3560,"version":2,"created":1554879630000,"modified":1554879633000,"deprecated":false,"name":"Solute carrier family 12 member 6","accession":"Q9UHW9","gene":"SLC12A6","description":"Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.7394306520658187,"antibodyCount":161,"monoclonalCount":2,"pubmedCount":null,"jensenScore":58.400133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.36273450387438,"pubTatorScore":1.5914258120572302,"self":"https://pharos.nih.gov/idg/api/v1/targets(3560)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3560)/properties"},"_links":{"count":1191,"href":"https://pharos.nih.gov/idg/api/v1/targets(3560)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(3560)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3560)/publications"},"_namespace":null},{"id":3561,"version":2,"created":1554879634000,"modified":1554879637000,"deprecated":false,"name":"Otoferlin","accession":"Q9HC10","gene":"OTOF","description":"Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0574339270083994,"antibodyCount":45,"monoclonalCount":9,"pubmedCount":null,"jensenScore":118.6973,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.30149328327283,"pubTatorScore":1.9672466173282577,"self":"https://pharos.nih.gov/idg/api/v1/targets(3561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3561)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(3561)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3561)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3561)/publications"},"_namespace":null},{"id":3562,"version":2,"created":1554879638000,"modified":1554879641000,"deprecated":false,"name":"Unconventional myosin-VIIa","accession":"Q13402","gene":"MYO7A","description":"Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.147128585815026,"antibodyCount":129,"monoclonalCount":19,"pubmedCount":null,"jensenScore":133.489398,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.6307256771199,"pubTatorScore":2.2495399601613046,"self":"https://pharos.nih.gov/idg/api/v1/targets(3562)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(3562)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3562)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(3562)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3562)/publications"},"_namespace":null},{"id":3563,"version":2,"created":1554879642000,"modified":1554879645000,"deprecated":false,"name":"Angiopoietin-related protein 1","accession":"O95841","gene":"ANGPTL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2702883922675596,"antibodyCount":252,"monoclonalCount":55,"pubmedCount":null,"jensenScore":19.305887,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.479071575332064,"pubTatorScore":1.1120035095710106,"self":"https://pharos.nih.gov/idg/api/v1/targets(3563)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(3563)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(3563)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3563)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3563)/publications"},"_namespace":null},{"id":3564,"version":2,"created":1554879646000,"modified":1554879648000,"deprecated":false,"name":"Cholinephosphotransferase 1","accession":"Q8WUD6","gene":"CHPT1","description":"Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4231288343172364,"antibodyCount":80,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.46948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.35409163530955,"pubTatorScore":2.0027110293498636,"self":"https://pharos.nih.gov/idg/api/v1/targets(3564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(3564)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(3564)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3564)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3564)/publications"},"_namespace":null},{"id":3565,"version":2,"created":1554879649000,"modified":1554879650000,"deprecated":false,"name":"Putative postmeiotic segregation increased 2-like protein 3","accession":"Q13401","gene":"PMS2P3","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-2.192990908348557,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":339.471466,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.43163169371804,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3565)/properties"},"_links":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3565)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3565)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3565)/publications"},"_namespace":null},{"id":3566,"version":3,"created":1554879650000,"modified":1555034849000,"deprecated":false,"name":"Coiled-coil domain-containing protein 12","accession":"Q8WUD4","gene":"CCDC12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.0944212132247824,"antibodyCount":92,"monoclonalCount":4,"pubmedCount":null,"jensenScore":1.488413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":27.098084922875785,"pubTatorScore":0.3697457815520694,"self":"https://pharos.nih.gov/idg/api/v1/targets(3566)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(3566)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3566)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3566)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3566)/publications"},"_namespace":null},{"id":3567,"version":2,"created":1554879653000,"modified":1554879655000,"deprecated":false,"name":"Xin actin-binding repeat-containing protein 2","accession":"A4UGR9","gene":"XIRP2","description":"Protects actin filaments from depolymerization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9411504413081488,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.061585,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.46443410596187,"pubTatorScore":0.8572689762182614,"self":"https://pharos.nih.gov/idg/api/v1/targets(3567)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(3567)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(3567)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3567)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3567)/publications"},"_namespace":null},{"id":3568,"version":3,"created":1554879655000,"modified":1555034851000,"deprecated":false,"name":"Ras-related protein Rab-2B","accession":"Q8WUD1","gene":"RAB2B","description":"Required for protein transport from the endoplasmic reticulum to the Golgi complex.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5430327790177605,"antibodyCount":171,"monoclonalCount":25,"pubmedCount":null,"jensenScore":3.115525,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":34,"knowledgeAvailability":32.17635497037733,"pubTatorScore":0.5064404922612356,"self":"https://pharos.nih.gov/idg/api/v1/targets(3568)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(3568)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(3568)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3568)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3568)/publications"},"_namespace":null},{"id":3569,"version":2,"created":1554879658000,"modified":1554879661000,"deprecated":false,"name":"39S ribosomal protein L49, mitochondrial","accession":"Q13405","gene":"MRPL49","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.763666834332433,"antibodyCount":76,"monoclonalCount":2,"pubmedCount":null,"jensenScore":555.08153,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.252731766058226,"pubTatorScore":1.2820427806115613,"self":"https://pharos.nih.gov/idg/api/v1/targets(3569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(3569)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(3569)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3569)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3569)/publications"},"_namespace":null},{"id":3570,"version":2,"created":1554879661000,"modified":1554879664000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 variant 1","accession":"Q13404","gene":"UBE2V1","description":"Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3315346873707419,"antibodyCount":188,"monoclonalCount":4,"pubmedCount":null,"jensenScore":18.044592,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.022731286725904,"pubTatorScore":1.4807696819442846,"self":"https://pharos.nih.gov/idg/api/v1/targets(3570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3570)/properties"},"_links":{"count":1061,"href":"https://pharos.nih.gov/idg/api/v1/targets(3570)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(3570)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(3570)/publications"},"_namespace":null},{"id":3571,"version":2,"created":1554879665000,"modified":1554879666000,"deprecated":false,"name":"Guanylyl cyclase-activating protein 3","accession":"O95843","gene":"GUCA1C","description":"Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.022276395145446673,"antibodyCount":125,"monoclonalCount":19,"pubmedCount":null,"jensenScore":1.104251,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.520469201414233,"pubTatorScore":0.5778745685456463,"self":"https://pharos.nih.gov/idg/api/v1/targets(3571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3571)/properties"},"_links":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(3571)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3571)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3571)/publications"},"_namespace":null},{"id":3572,"version":3,"created":1554879666000,"modified":1555034854000,"deprecated":false,"name":"Cytoplasmic dynein 1 intermediate chain 2","accession":"Q13409","gene":"DYNC1I2","description":"Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.296338124671628,"antibodyCount":104,"monoclonalCount":15,"pubmedCount":null,"jensenScore":178.528577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":43.29803570363316,"pubTatorScore":1.877659232599495,"self":"https://pharos.nih.gov/idg/api/v1/targets(3572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":504,"href":"https://pharos.nih.gov/idg/api/v1/targets(3572)/properties"},"_links":{"count":1143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3572)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(3572)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3572)/publications"},"_namespace":null},{"id":3573,"version":3,"created":1554879670000,"modified":1555034855000,"deprecated":false,"name":"Lamin-B receptor","accession":"Q14739","gene":"LBR","description":"Anchors the lamina and the heterochromatin to the inner nuclear membrane.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-3.0296066279204,"antibodyCount":134,"monoclonalCount":10,"pubmedCount":null,"jensenScore":1057.111023,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":51.62297117632519,"pubTatorScore":2.429520351651044,"self":"https://pharos.nih.gov/idg/api/v1/targets(3573)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(3573)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(3573)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3573)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3573)/publications"},"_namespace":null},{"id":3574,"version":2,"created":1554879677000,"modified":1554879680000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform","accession":"Q14738","gene":"PPP2R5D","description":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7084270169549897,"antibodyCount":261,"monoclonalCount":41,"pubmedCount":null,"jensenScore":3.589442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.754451448650286,"pubTatorScore":0.4925276789073224,"self":"https://pharos.nih.gov/idg/api/v1/targets(3574)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(3574)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(3574)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3574)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3574)/publications"},"_namespace":null},{"id":3575,"version":2,"created":1554879681000,"modified":1554879681000,"deprecated":false,"name":"Transmembrane protein 202","accession":"A6NGA9","gene":"TMEM202","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.354784741371561,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3575)/properties"},"_links":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3575)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(3575)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3575)/publications"},"_namespace":null},{"id":3576,"version":2,"created":1554879681000,"modified":1554879683000,"deprecated":false,"name":"Splicing factor 3B subunit 6","accession":"Q9Y3B4","gene":"SF3B6","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6596404717513008,"antibodyCount":100,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.588745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.34691053000288,"pubTatorScore":0.6020598827543283,"self":"https://pharos.nih.gov/idg/api/v1/targets(3576)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(3576)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(3576)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3576)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3576)/publications"},"_namespace":null},{"id":3577,"version":2,"created":1554879684000,"modified":1554879687000,"deprecated":false,"name":"39S ribosomal protein L11, mitochondrial","accession":"Q9Y3B7","gene":"MRPL11","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.635547562217721,"antibodyCount":198,"monoclonalCount":37,"pubmedCount":null,"jensenScore":3.411049,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.106879663064824,"pubTatorScore":0.48192008987676016,"self":"https://pharos.nih.gov/idg/api/v1/targets(3577)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(3577)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(3577)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3577)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3577)/publications"},"_namespace":null},{"id":3578,"version":3,"created":1554879688000,"modified":1555034857000,"deprecated":false,"name":"ER membrane protein complex subunit 9","accession":"Q9Y3B6","gene":"EMC9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":24,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.095238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":26.409291439457224,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3578)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(3578)/properties"},"_links":{"count":798,"href":"https://pharos.nih.gov/idg/api/v1/targets(3578)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3578)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3578)/publications"},"_namespace":null},{"id":3579,"version":2,"created":1554879690000,"modified":1554879693000,"deprecated":false,"name":"Coiled-coil domain-containing protein 190","accession":"Q86UF4","gene":"CCDC190","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4471580313422192,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.35461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-1.6434578880512396,"self":"https://pharos.nih.gov/idg/api/v1/targets(3579)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(3579)/properties"},"_links":{"count":601,"href":"https://pharos.nih.gov/idg/api/v1/targets(3579)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3579)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3579)/publications"},"_namespace":null},{"id":3580,"version":2,"created":1554879693000,"modified":1554879696000,"deprecated":false,"name":"Collagen alpha-1(XV) chain","accession":"P39059","gene":"COL15A1","description":"Restin potently inhibits angiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1871630859131017,"antibodyCount":74,"monoclonalCount":20,"pubmedCount":null,"jensenScore":15.512158,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.877016029706276,"pubTatorScore":1.3953159593904711,"self":"https://pharos.nih.gov/idg/api/v1/targets(3580)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(3580)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(3580)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3580)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3580)/publications"},"_namespace":null},{"id":3581,"version":2,"created":1554879697000,"modified":1554879697000,"deprecated":false,"name":"Putative UPF0607 protein FLJ37424","accession":"Q8N9G6","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3581)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3581)/properties"},"_links":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3581)/links"},"_synonyms":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3581)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3581)/publications"},"_namespace":null},{"id":3582,"version":2,"created":1554879697000,"modified":1554879699000,"deprecated":false,"name":"PRELI domain containing protein 3B","accession":"Q9Y3B1","gene":"PRELID3B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.15970084431516016,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.165151,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.007299385959992831,"self":"https://pharos.nih.gov/idg/api/v1/targets(3582)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3582)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(3582)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3582)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3582)/publications"},"_namespace":null},{"id":3583,"version":2,"created":1554879700000,"modified":1554879701000,"deprecated":false,"name":"Transmembrane protein 191C","accession":"A6NGB0","gene":"TMEM191C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.683171784044585,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3583)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3583)/properties"},"_links":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(3583)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(3583)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3583)/publications"},"_namespace":null},{"id":3584,"version":2,"created":1554879701000,"modified":1554879704000,"deprecated":false,"name":"Adhesion G protein-coupled receptor E2","accession":"Q9UHX3","gene":"ADGRE2","description":"Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.678620325131004,"antibodyCount":312,"monoclonalCount":106,"pubmedCount":null,"jensenScore":48.242262,"patentCount":4278,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.8033595096263,"pubTatorScore":1.5813444314642418,"self":"https://pharos.nih.gov/idg/api/v1/targets(3584)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(3584)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(3584)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3584)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3584)/publications"},"_namespace":null},{"id":3585,"version":3,"created":1554879704000,"modified":1555034858000,"deprecated":false,"name":"cTAGE family member 6","accession":"Q86UF2","gene":"CTAGE6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":27,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":8.736538520741462,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3585)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(3585)/properties"},"_links":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(3585)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3585)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3585)/publications"},"_namespace":null},{"id":3586,"version":3,"created":1554879707000,"modified":1555034859000,"deprecated":false,"name":"Transmembrane emp24 domain-containing protein 7","accession":"Q9Y3B3","gene":"TMED7","description":"Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.23317748075395003,"antibodyCount":18,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.140173,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":36,"knowledgeAvailability":30.50343151822466,"pubTatorScore":1.148142175830599,"self":"https://pharos.nih.gov/idg/api/v1/targets(3586)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3586)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(3586)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3586)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3586)/publications"},"_namespace":null},{"id":3587,"version":3,"created":1554879710000,"modified":1555034860000,"deprecated":false,"name":"Tetraspanin-33","accession":"Q86UF1","gene":"TSPAN33","description":"Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4622488867747854,"antibodyCount":135,"monoclonalCount":22,"pubmedCount":null,"jensenScore":281.534937,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":25.889540841252817,"pubTatorScore":3.1734045858307605,"self":"https://pharos.nih.gov/idg/api/v1/targets(3587)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(3587)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(3587)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3587)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3587)/publications"},"_namespace":null},{"id":3588,"version":3,"created":1554879713000,"modified":1555034862000,"deprecated":false,"name":"Poly(U)-binding-splicing factor PUF60","accession":"Q9UHX1","gene":"PUF60","description":"DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4375372584926072,"antibodyCount":285,"monoclonalCount":59,"pubmedCount":null,"jensenScore":30.218565,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":42.93094226156334,"pubTatorScore":1.3989046511420236,"self":"https://pharos.nih.gov/idg/api/v1/targets(3588)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(3588)/properties"},"_links":{"count":1202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3588)/links"},"_synonyms":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(3588)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3588)/publications"},"_namespace":null},{"id":3589,"version":2,"created":1554879717000,"modified":1554879720000,"deprecated":false,"name":"Transmembrane protein 165","accession":"Q9HC07","gene":"TMEM165","description":"May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5601059289777781,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.213209,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.71058608527716,"pubTatorScore":1.1712387465018426,"self":"https://pharos.nih.gov/idg/api/v1/targets(3589)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3589)/properties"},"_links":{"count":1150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3589)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3589)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3589)/publications"},"_namespace":null},{"id":3590,"version":3,"created":1554879721000,"modified":1555034863000,"deprecated":false,"name":"Exosome complex component CSL4","accession":"Q9Y3B2","gene":"EXOSC1","description":"Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.07437802978759,"antibodyCount":129,"monoclonalCount":39,"pubmedCount":null,"jensenScore":110.188993,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":34.840286799061005,"pubTatorScore":0.5532759246561084,"self":"https://pharos.nih.gov/idg/api/v1/targets(3590)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(3590)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(3590)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3590)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3590)/publications"},"_namespace":null},{"id":3591,"version":2,"created":1554879725000,"modified":1554879727000,"deprecated":false,"name":"Uridine diphosphate glucose pyrophosphatase","accession":"O95848","gene":"NUDT14","description":"Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6760796831838493,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.465803,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.85913864850011,"pubTatorScore":0.6852440296336714,"self":"https://pharos.nih.gov/idg/api/v1/targets(3591)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(3591)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(3591)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3591)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3591)/publications"},"_namespace":null},{"id":3592,"version":2,"created":1554879728000,"modified":1554879730000,"deprecated":false,"name":"Probable helicase with zinc finger domain","accession":"P42694","gene":"HELZ","description":"May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5020878010599477,"antibodyCount":63,"monoclonalCount":42,"pubmedCount":null,"jensenScore":22.116643,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.384934588793165,"pubTatorScore":0.6548180725420142,"self":"https://pharos.nih.gov/idg/api/v1/targets(3592)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(3592)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(3592)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3592)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3592)/publications"},"_namespace":null},{"id":3593,"version":2,"created":1554879731000,"modified":1554879733000,"deprecated":false,"name":"Mitochondrial uncoupling protein 4","accession":"O95847","gene":"SLC25A27","description":"UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.5393599552088812,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":38.040682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.89626549770826,"pubTatorScore":1.5080864451247802,"self":"https://pharos.nih.gov/idg/api/v1/targets(3593)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(3593)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(3593)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3593)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3593)/publications"},"_namespace":null},{"id":3594,"version":3,"created":1554879734000,"modified":1555034864000,"deprecated":false,"name":"Mitotic spindle assembly checkpoint protein MAD2B","accession":"Q9UI95","gene":"MAD2L2","description":"Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6922706182433938,"antibodyCount":111,"monoclonalCount":4,"pubmedCount":null,"jensenScore":56.462271,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.696291497273116,"pubTatorScore":1.6506316850518306,"self":"https://pharos.nih.gov/idg/api/v1/targets(3594)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(3594)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(3594)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3594)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3594)/publications"},"_namespace":null},{"id":3595,"version":2,"created":1554879738000,"modified":1554879741000,"deprecated":false,"name":"RRP15-like protein","accession":"Q9Y3B9","gene":"RRP15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.13117952290419047,"antibodyCount":33,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.532508,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.91904343519981,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3595)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(3595)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3595)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3595)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3595)/publications"},"_namespace":null},{"id":3596,"version":3,"created":1554879741000,"modified":1555034866000,"deprecated":false,"name":"Condensin-2 complex subunit D3","accession":"P42695","gene":"NCAPD3","description":"Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1807888878498742,"antibodyCount":141,"monoclonalCount":41,"pubmedCount":null,"jensenScore":14.652372,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":41.00239572385528,"pubTatorScore":0.8481890553893402,"self":"https://pharos.nih.gov/idg/api/v1/targets(3596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3596)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(3596)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3596)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3596)/publications"},"_namespace":null},{"id":3597,"version":3,"created":1554879744000,"modified":1555034869000,"deprecated":false,"name":"RNA-binding protein 34","accession":"P42696","gene":"RBM34","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.03329969039575682,"antibodyCount":79,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.827778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":77,"knowledgeAvailability":32.2560050858424,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(3597)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(3597)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(3597)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3597)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3597)/publications"},"_namespace":null},{"id":3598,"version":2,"created":1554879747000,"modified":1554879750000,"deprecated":false,"name":"Oligoribonuclease, mitochondrial","accession":"Q9Y3B8","gene":"REXO2","description":"3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1550192353287407,"antibodyCount":115,"monoclonalCount":41,"pubmedCount":null,"jensenScore":143.844656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.76388993304444,"pubTatorScore":2.2182357123172776,"self":"https://pharos.nih.gov/idg/api/v1/targets(3598)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(3598)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3598)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3598)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3598)/publications"},"_namespace":null},{"id":3599,"version":2,"created":1554879751000,"modified":1554879751000,"deprecated":false,"name":"Serine protease 44","accession":"E7EML9","gene":"PRSS44","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.202527679792577,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3599)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3599)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3599)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3599)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3599)/publications"},"_namespace":null},{"id":3600,"version":3,"created":1554879751000,"modified":1555034870000,"deprecated":false,"name":"Butyrophilin subfamily 1 member A1","accession":"Q13410","gene":"BTN1A1","description":"May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.993733821982223,"antibodyCount":166,"monoclonalCount":118,"pubmedCount":null,"jensenScore":93.908672,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":25.12376430032495,"pubTatorScore":1.4549481640927326,"self":"https://pharos.nih.gov/idg/api/v1/targets(3600)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3600)/properties"},"_links":{"count":686,"href":"https://pharos.nih.gov/idg/api/v1/targets(3600)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3600)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3600)/publications"},"_namespace":null},{"id":3601,"version":2,"created":1554879753000,"modified":1554879754000,"deprecated":false,"name":"Envoplakin-like protein","accession":"A8MZ36","gene":"EVPLL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.385135198533595,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3601)/properties"},"_links":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(3601)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3601)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3601)/publications"},"_namespace":null},{"id":3602,"version":2,"created":1554879754000,"modified":1554879756000,"deprecated":false,"name":"Tetraspanin-13","accession":"O95857","gene":"TSPAN13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4438215683462997,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.867719,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.714943182865184,"pubTatorScore":0.7097305607652878,"self":"https://pharos.nih.gov/idg/api/v1/targets(3602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(3602)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(3602)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3602)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3602)/publications"},"_namespace":null},{"id":3603,"version":2,"created":1554879757000,"modified":1554879759000,"deprecated":false,"name":"Origin recognition complex subunit 2","accession":"Q13416","gene":"ORC2","description":"Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6827465855689574,"antibodyCount":168,"monoclonalCount":45,"pubmedCount":null,"jensenScore":4.916414,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.90365628142721,"pubTatorScore":1.6673946134161426,"self":"https://pharos.nih.gov/idg/api/v1/targets(3603)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(3603)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(3603)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3603)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3603)/publications"},"_namespace":null},{"id":3604,"version":2,"created":1554879760000,"modified":1554879765000,"deprecated":false,"name":"Origin recognition complex subunit 1","accession":"Q13415","gene":"ORC1","description":"Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4257262899171939,"antibodyCount":148,"monoclonalCount":55,"pubmedCount":null,"jensenScore":27.958666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.12257888393513,"pubTatorScore":1.8227412835932426,"self":"https://pharos.nih.gov/idg/api/v1/targets(3604)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(3604)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(3604)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3604)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3604)/publications"},"_namespace":null},{"id":3605,"version":3,"created":1554879766000,"modified":1555034871000,"deprecated":false,"name":"Conserved oligomeric Golgi complex subunit 2","accession":"Q14746","gene":"COG2","description":"Required for normal Golgi morphology and function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.6571235212088857,"antibodyCount":169,"monoclonalCount":30,"pubmedCount":null,"jensenScore":4250.648492,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":36.75327277129783,"pubTatorScore":3.2842113184274933,"self":"https://pharos.nih.gov/idg/api/v1/targets(3605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(3605)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(3605)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3605)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3605)/publications"},"_namespace":null},{"id":3606,"version":2,"created":1554879770000,"modified":1554879773000,"deprecated":false,"name":"Cytosolic Fe-S cluster assembly factor NUBP1","accession":"P53384","gene":"NUBP1","description":"Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3186677512761449,"antibodyCount":105,"monoclonalCount":9,"pubmedCount":null,"jensenScore":19.964519,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.5721539890529,"pubTatorScore":1.2368190584010652,"self":"https://pharos.nih.gov/idg/api/v1/targets(3606)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(3606)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(3606)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3606)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3606)/publications"},"_namespace":null},{"id":3607,"version":3,"created":1554879773000,"modified":1555034874000,"deprecated":false,"name":"WASH complex subunit 3","accession":"Q9Y3C0","gene":"WASHC3","description":"Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.22017516739715365,"antibodyCount":26,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.674242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":43,"knowledgeAvailability":0.0,"pubTatorScore":-0.2730015434978737,"self":"https://pharos.nih.gov/idg/api/v1/targets(3607)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(3607)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(3607)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3607)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3607)/publications"},"_namespace":null},{"id":3608,"version":2,"created":1554879776000,"modified":1554879778000,"deprecated":false,"name":"Glycine N-methyltransferase","accession":"Q14749","gene":"GNMT","description":"Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5651739484296077,"antibodyCount":216,"monoclonalCount":22,"pubmedCount":null,"jensenScore":40.828764,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.45790339184284,"pubTatorScore":1.931281253899364,"self":"https://pharos.nih.gov/idg/api/v1/targets(3608)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3608)/properties"},"_links":{"count":853,"href":"https://pharos.nih.gov/idg/api/v1/targets(3608)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3608)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3608)/publications"},"_namespace":null},{"id":3609,"version":3,"created":1554879779000,"modified":1555034875000,"deprecated":false,"name":"Integrin-linked protein kinase","accession":"Q13418","gene":"ILK","description":"Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.7545046056053426,"antibodyCount":608,"monoclonalCount":45,"pubmedCount":null,"jensenScore":679.07101,"patentCount":37703,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":49.187110950156956,"pubTatorScore":2.587930339415432,"self":"https://pharos.nih.gov/idg/api/v1/targets(3609)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":722,"href":"https://pharos.nih.gov/idg/api/v1/targets(3609)/properties"},"_links":{"count":1407,"href":"https://pharos.nih.gov/idg/api/v1/targets(3609)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3609)/synonyms"},"_publications":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(3609)/publications"},"_namespace":null},{"id":3610,"version":2,"created":1554879788000,"modified":1554879790000,"deprecated":false,"name":"Transmembrane protein 221","accession":"A6NGB7","gene":"TMEM221","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.534396606561081,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3610)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3610)/properties"},"_links":{"count":729,"href":"https://pharos.nih.gov/idg/api/v1/targets(3610)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(3610)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3610)/publications"},"_namespace":null},{"id":3611,"version":3,"created":1554879790000,"modified":1555034878000,"deprecated":false,"name":"WAS/WASL-interacting protein family member 3","accession":"A6NGB9","gene":"WIPF3","description":"May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3383505603864236,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.11756,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":23.4996033971021,"pubTatorScore":0.9054102931256134,"self":"https://pharos.nih.gov/idg/api/v1/targets(3611)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(3611)/properties"},"_links":{"count":832,"href":"https://pharos.nih.gov/idg/api/v1/targets(3611)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3611)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3611)/publications"},"_namespace":null},{"id":3612,"version":3,"created":1554879793000,"modified":1555034879000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase-like 1","accession":"Q9Y3C6","gene":"PPIL1","description":"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8827142170523933,"antibodyCount":184,"monoclonalCount":67,"pubmedCount":null,"jensenScore":7.982323,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.13505617988017,"pubTatorScore":1.7751452963987524,"self":"https://pharos.nih.gov/idg/api/v1/targets(3612)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(3612)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(3612)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3612)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3612)/publications"},"_namespace":null},{"id":3613,"version":3,"created":1554879796000,"modified":1555034881000,"deprecated":false,"name":"Nuclear receptor-binding protein","accession":"Q9UHY1","gene":"NRBP1","description":"May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-0.9474881999029482,"antibodyCount":251,"monoclonalCount":103,"pubmedCount":null,"jensenScore":10.387002,"patentCount":2028,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":37.21164039655568,"pubTatorScore":1.4785664955938433,"self":"https://pharos.nih.gov/idg/api/v1/targets(3613)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(3613)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(3613)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3613)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(3613)/publications"},"_namespace":null},{"id":3614,"version":3,"created":1554879800000,"modified":1555034883000,"deprecated":false,"name":"Leucine-rich repeat transmembrane neuronal protein 1","accession":"Q86UE6","gene":"LRRTM1","description":"Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.271740230585371,"antibodyCount":155,"monoclonalCount":26,"pubmedCount":null,"jensenScore":15.802912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":38,"knowledgeAvailability":25.36533789755142,"pubTatorScore":1.1731347038117184,"self":"https://pharos.nih.gov/idg/api/v1/targets(3614)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(3614)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(3614)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3614)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3614)/publications"},"_namespace":null},{"id":3615,"version":3,"created":1554879802000,"modified":1555034886000,"deprecated":false,"name":"Lysophospholipase D GDPD1","accession":"Q8N9F7","gene":"GDPD1","description":"Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7187784034801644,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.865523,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":28.555510792416307,"pubTatorScore":0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3615)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(3615)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(3615)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3615)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3615)/publications"},"_namespace":null},{"id":3616,"version":3,"created":1554879805000,"modified":1555034888000,"deprecated":false,"name":"RING finger protein 11","accession":"Q9Y3C5","gene":"RNF11","description":"Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2880934427262685,"antibodyCount":120,"monoclonalCount":9,"pubmedCount":null,"jensenScore":23.426243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":36.042706479313345,"pubTatorScore":1.288497565631499,"self":"https://pharos.nih.gov/idg/api/v1/targets(3616)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(3616)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(3616)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3616)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3616)/publications"},"_namespace":null},{"id":3617,"version":2,"created":1554879808000,"modified":1554879810000,"deprecated":false,"name":"Ubiquitin-fold modifier-conjugating enzyme 1","accession":"Q9Y3C8","gene":"UFC1","description":"E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.031685758582995,"antibodyCount":165,"monoclonalCount":3,"pubmedCount":null,"jensenScore":9.111369,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.19188551722175,"pubTatorScore":1.0012749525136013,"self":"https://pharos.nih.gov/idg/api/v1/targets(3617)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(3617)/properties"},"_links":{"count":1009,"href":"https://pharos.nih.gov/idg/api/v1/targets(3617)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3617)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3617)/publications"},"_namespace":null},{"id":3618,"version":3,"created":1554879811000,"modified":1555034890000,"deprecated":false,"name":"Protein LYRIC","accession":"Q86UE4","gene":"MTDH","description":"Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6032777214962266,"antibodyCount":249,"monoclonalCount":96,"pubmedCount":null,"jensenScore":417.272452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":50.70093141911194,"pubTatorScore":2.380664314639703,"self":"https://pharos.nih.gov/idg/api/v1/targets(3618)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":632,"href":"https://pharos.nih.gov/idg/api/v1/targets(3618)/properties"},"_links":{"count":1404,"href":"https://pharos.nih.gov/idg/api/v1/targets(3618)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3618)/synonyms"},"_publications":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3618)/publications"},"_namespace":null},{"id":3619,"version":2,"created":1554879817000,"modified":1554879819000,"deprecated":false,"name":"Mediator of RNA polymerase II transcription subunit 31","accession":"Q9Y3C7","gene":"MED31","description":"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1904755016784105,"antibodyCount":61,"monoclonalCount":11,"pubmedCount":null,"jensenScore":15.11064,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.59024242032005,"pubTatorScore":0.6145456325449262,"self":"https://pharos.nih.gov/idg/api/v1/targets(3619)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(3619)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(3619)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3619)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3619)/publications"},"_namespace":null},{"id":3620,"version":2,"created":1554879819000,"modified":1554879822000,"deprecated":false,"name":"Zinc finger protein 546","accession":"Q86UE3","gene":"ZNF546","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.755424535097873,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3620)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3620)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(3620)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3620)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3620)/publications"},"_namespace":null},{"id":3621,"version":2,"created":1554879822000,"modified":1554879822000,"deprecated":false,"name":"TBC1 domain family member 3G","accession":"Q6DHY5","gene":"TBC1D3G","description":"Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3621)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3621)/properties"},"_links":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(3621)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3621)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3621)/publications"},"_namespace":null},{"id":3622,"version":3,"created":1554879822000,"modified":1555034892000,"deprecated":false,"name":"Nucleolar protein 16","accession":"Q9Y3C1","gene":"NOP16","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5854607290742062,"antibodyCount":117,"monoclonalCount":10,"pubmedCount":null,"jensenScore":3.595634,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.922029444031196,"pubTatorScore":0.6056640797046802,"self":"https://pharos.nih.gov/idg/api/v1/targets(3622)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3622)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(3622)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3622)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3622)/publications"},"_namespace":null},{"id":3623,"version":2,"created":1554879825000,"modified":1554879827000,"deprecated":false,"name":"Zinc finger protein 454","accession":"Q8N9F8","gene":"ZNF454","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.659129505121015,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(3623)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(3623)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(3623)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3623)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3623)/publications"},"_namespace":null},{"id":3624,"version":2,"created":1554879827000,"modified":1554879830000,"deprecated":false,"name":"EKC/KEOPS complex subunit TPRKB","accession":"Q9Y3C4","gene":"TPRKB","description":"Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7949967468750929,"antibodyCount":134,"monoclonalCount":73,"pubmedCount":null,"jensenScore":4.880552,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.888154766605236,"pubTatorScore":0.308208509095282,"self":"https://pharos.nih.gov/idg/api/v1/targets(3624)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(3624)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(3624)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3624)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3624)/publications"},"_namespace":null},{"id":3625,"version":2,"created":1554879830000,"modified":1554879832000,"deprecated":false,"name":"TLC domain-containing protein 2","accession":"A6NGC4","gene":"TLCD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3010299956639812,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.285714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.49930400755704,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3625)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(3625)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(3625)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3625)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3625)/publications"},"_namespace":null},{"id":3626,"version":3,"created":1554879833000,"modified":1555034893000,"deprecated":false,"name":"Tyrosine-protein kinase Tec","accession":"P42680","gene":"TEC","description":"Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.7569016257959035,"antibodyCount":247,"monoclonalCount":38,"pubmedCount":null,"jensenScore":9.248194,"patentCount":122028,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":45.10914735506548,"pubTatorScore":1.7842021183829004,"self":"https://pharos.nih.gov/idg/api/v1/targets(3626)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(3626)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(3626)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(3626)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3626)/publications"},"_namespace":null},{"id":3627,"version":3,"created":1554879839000,"modified":1555034895000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 7-like","accession":"Q5H9L4","gene":"TAF7L","description":"Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3412931439156983,"antibodyCount":82,"monoclonalCount":9,"pubmedCount":null,"jensenScore":22.55615,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":25.59799984638183,"pubTatorScore":1.043596105240256,"self":"https://pharos.nih.gov/idg/api/v1/targets(3627)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(3627)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(3627)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3627)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3627)/publications"},"_namespace":null},{"id":3628,"version":2,"created":1554879842000,"modified":1554879844000,"deprecated":false,"name":"Fasciculation and elongation protein zeta-2","accession":"Q9UHY8","gene":"FEZ2","description":"Involved in axonal outgrowth and fasciculation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4074240196234459,"antibodyCount":141,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.261193,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.275593862677226,"pubTatorScore":0.15670781851465904,"self":"https://pharos.nih.gov/idg/api/v1/targets(3628)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3628)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(3628)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3628)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3628)/publications"},"_namespace":null},{"id":3629,"version":2,"created":1554879845000,"modified":1554879850000,"deprecated":false,"name":"Tyrosine-protein kinase TXK","accession":"P42681","gene":"TXK","description":"Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.283648525166554,"antibodyCount":194,"monoclonalCount":71,"pubmedCount":null,"jensenScore":191.088077,"patentCount":50553,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.12396530275271,"pubTatorScore":2.4687332437404277,"self":"https://pharos.nih.gov/idg/api/v1/targets(3629)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3629)/publications"},"_namespace":null},{"id":3630,"version":3,"created":1554879850000,"modified":1555034896000,"deprecated":false,"name":"Enolase-phosphatase E1","accession":"Q9UHY7","gene":"ENOPH1","description":"Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9836334384934999,"antibodyCount":124,"monoclonalCount":38,"pubmedCount":null,"jensenScore":9.95626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":36.62768161725971,"pubTatorScore":1.1279142943715932,"self":"https://pharos.nih.gov/idg/api/v1/targets(3630)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3630)/publications"},"_namespace":null},{"id":3631,"version":2,"created":1554879853000,"modified":1554879856000,"deprecated":false,"name":"Tetraspanin-12","accession":"O95859","gene":"TSPAN12","description":"Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.331299473586608,"antibodyCount":141,"monoclonalCount":16,"pubmedCount":null,"jensenScore":21.474008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.04780342228656,"pubTatorScore":1.874002327406041,"self":"https://pharos.nih.gov/idg/api/v1/targets(3631)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3631)/publications"},"_namespace":null},{"id":3632,"version":2,"created":1554879857000,"modified":1554879859000,"deprecated":false,"name":"Tetraspanin-15","accession":"O95858","gene":"TSPAN15","description":"Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.296533821285532,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.33737,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.367044336836965,"pubTatorScore":0.3706276157340919,"self":"https://pharos.nih.gov/idg/api/v1/targets(3632)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3632)/publications"},"_namespace":null},{"id":3633,"version":2,"created":1554879860000,"modified":1554879862000,"deprecated":false,"name":"Cerebral cavernous malformations 2 protein-like","accession":"Q9NUG4","gene":"CCM2L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.242262,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.91791595440127,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3633)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/properties"},"_links":{"count":723,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3633)/publications"},"_namespace":null},{"id":3634,"version":2,"created":1554879862000,"modified":1554879871000,"deprecated":false,"name":"Abelson tyrosine-protein kinase 2","accession":"P42684","gene":"ABL2","description":"Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.8629327696584348,"antibodyCount":358,"monoclonalCount":107,"pubmedCount":null,"jensenScore":71.204995,"patentCount":8984519,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.45675342150125,"pubTatorScore":1.6525378104983264,"self":"https://pharos.nih.gov/idg/api/v1/targets(3634)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3634)/publications"},"_namespace":null},{"id":3635,"version":2,"created":1554879872000,"modified":1554879877000,"deprecated":false,"name":"Tyrosine-protein kinase FRK","accession":"P42685","gene":"FRK","description":"Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.6836546867359994,"antibodyCount":394,"monoclonalCount":117,"pubmedCount":null,"jensenScore":49.1682,"patentCount":17534,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.26682722547527,"pubTatorScore":1.8588596467542158,"self":"https://pharos.nih.gov/idg/api/v1/targets(3635)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3635)/publications"},"_namespace":null},{"id":3636,"version":3,"created":1554879878000,"modified":1555034897000,"deprecated":false,"name":"Transcription elongation factor A protein-like 5","accession":"Q5H9L2","gene":"TCEAL5","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":18,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.428571,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":17.300123255965254,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3636)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3636)/publications"},"_namespace":null},{"id":3637,"version":3,"created":1554879880000,"modified":1555034898000,"deprecated":false,"name":"Serine/threonine-protein kinase tousled-like 2","accession":"Q86UE8","gene":"TLK2","description":"Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.9545555531236226,"antibodyCount":210,"monoclonalCount":57,"pubmedCount":null,"jensenScore":10.069359,"patentCount":1607,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.544209895708114,"pubTatorScore":0.9507549598983293,"self":"https://pharos.nih.gov/idg/api/v1/targets(3637)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3637)/publications"},"_namespace":null},{"id":3638,"version":2,"created":1554879883000,"modified":1554879886000,"deprecated":false,"name":"p53 and DNA damage-regulated protein 1","accession":"Q9NUG6","gene":"PDRG1","description":"May play a role in chaperone-mediated protein folding.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0084987662856586,"antibodyCount":96,"monoclonalCount":9,"pubmedCount":null,"jensenScore":9.955465,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.180798987588823,"pubTatorScore":0.7683914377703095,"self":"https://pharos.nih.gov/idg/api/v1/targets(3638)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3638)/publications"},"_namespace":null},{"id":3639,"version":2,"created":1554879887000,"modified":1554879890000,"deprecated":false,"name":"Alpha-1-syntrophin","accession":"Q13424","gene":"SNTA1","description":"Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4922694443867182,"antibodyCount":254,"monoclonalCount":109,"pubmedCount":null,"jensenScore":31.435838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.76502745922662,"pubTatorScore":1.1569363003466,"self":"https://pharos.nih.gov/idg/api/v1/targets(3639)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3639)/publications"},"_namespace":null},{"id":3640,"version":2,"created":1554879891000,"modified":1554879894000,"deprecated":false,"name":"Fatty acid desaturase 2","accession":"O95864","gene":"FADS2","description":"Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.5541110302858776,"antibodyCount":135,"monoclonalCount":2,"pubmedCount":null,"jensenScore":349.594681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.68490703078108,"pubTatorScore":2.484993288010833,"self":"https://pharos.nih.gov/idg/api/v1/targets(3640)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/properties"},"_links":{"count":1144,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/synonyms"},"_publications":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3640)/publications"},"_namespace":null},{"id":3641,"version":2,"created":1554879895000,"modified":1554879898000,"deprecated":false,"name":"NAD(P) transhydrogenase, mitochondrial","accession":"Q13423","gene":"NNT","description":"The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.496240630839991,"antibodyCount":112,"monoclonalCount":17,"pubmedCount":null,"jensenScore":309.231092,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.9236501877318,"pubTatorScore":1.295635548174394,"self":"https://pharos.nih.gov/idg/api/v1/targets(3641)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3641)/publications"},"_namespace":null},{"id":3642,"version":3,"created":1554879899000,"modified":1555034900000,"deprecated":false,"name":"Zinc finger protein SNAI1","accession":"O95863","gene":"SNAI1","description":"Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.286358278179855,"antibodyCount":566,"monoclonalCount":135,"pubmedCount":null,"jensenScore":1782.85577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":42.9388809278787,"pubTatorScore":3.2595040270110984,"self":"https://pharos.nih.gov/idg/api/v1/targets(3642)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/properties"},"_links":{"count":1367,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/synonyms"},"_publications":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(3642)/publications"},"_namespace":null},{"id":3643,"version":3,"created":1554879907000,"modified":1555034903000,"deprecated":false,"name":"DNA-binding protein Ikaros","accession":"Q13422","gene":"IKZF1","description":"Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.6673171919419114,"antibodyCount":400,"monoclonalCount":75,"pubmedCount":null,"jensenScore":483.578609,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":44.00603104328681,"pubTatorScore":2.6414700610362156,"self":"https://pharos.nih.gov/idg/api/v1/targets(3643)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":557,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/properties"},"_links":{"count":1260,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/synonyms"},"_publications":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3643)/publications"},"_namespace":null},{"id":3644,"version":3,"created":1554879913000,"modified":1555034906000,"deprecated":false,"name":"3'(2'),5'-bisphosphate nucleotidase 1","accession":"O95861","gene":"BPNT1","description":"Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9436593740214696,"antibodyCount":165,"monoclonalCount":28,"pubmedCount":null,"jensenScore":8.134722,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":35.99064384534747,"pubTatorScore":0.48192008987676016,"self":"https://pharos.nih.gov/idg/api/v1/targets(3644)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3644)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(3644)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3644)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3644)/publications"},"_namespace":null},{"id":3645,"version":2,"created":1554879916000,"modified":1554879919000,"deprecated":false,"name":"Mesothelin","accession":"Q13421","gene":"MSLN","description":"Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6606101792156633,"antibodyCount":542,"monoclonalCount":209,"pubmedCount":null,"jensenScore":452.072061,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.124115866982066,"pubTatorScore":2.543804405914648,"self":"https://pharos.nih.gov/idg/api/v1/targets(3645)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":422,"href":"https://pharos.nih.gov/idg/api/v1/targets(3645)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(3645)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3645)/synonyms"},"_publications":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3645)/publications"},"_namespace":null},{"id":3646,"version":2,"created":1554879920000,"modified":1554879922000,"deprecated":false,"name":"Protein FAM216A","accession":"Q8WUB2","gene":"FAM216A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":87,"monoclonalCount":20,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.919327426417603,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3646)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3646)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3646)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(3646)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3646)/publications"},"_namespace":null},{"id":3647,"version":2,"created":1554879923000,"modified":1554879923000,"deprecated":false,"name":"Putative uncharacterized protein FLJ38767","accession":"A8MZ25","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3647)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3647)/properties"},"_links":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3647)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3647)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3647)/publications"},"_namespace":null},{"id":3648,"version":3,"created":1554879923000,"modified":1555034907000,"deprecated":false,"name":"Lymphocyte antigen 6 complex locus protein G6d","accession":"O95868","gene":"LY6G6D","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4249011021459712,"antibodyCount":92,"monoclonalCount":71,"pubmedCount":null,"jensenScore":25.74128,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":15.508476338273404,"pubTatorScore":0.7540570007478075,"self":"https://pharos.nih.gov/idg/api/v1/targets(3648)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3648)/properties"},"_links":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(3648)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3648)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3648)/publications"},"_namespace":null},{"id":3649,"version":2,"created":1554879924000,"modified":1554879935000,"deprecated":false,"name":"ATP-citrate synthase","accession":"P53396","gene":"ACLY","description":"ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.827044056169575,"antibodyCount":332,"monoclonalCount":102,"pubmedCount":null,"jensenScore":654.341856,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.30002733439346,"pubTatorScore":2.2793922046817254,"self":"https://pharos.nih.gov/idg/api/v1/targets(3649)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(3649)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3649)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(3649)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3649)/publications"},"_namespace":null},{"id":3650,"version":2,"created":1554879936000,"modified":1554879940000,"deprecated":false,"name":"Treacle protein","accession":"Q13428","gene":"TCOF1","description":"Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.4411714751829883,"antibodyCount":131,"monoclonalCount":16,"pubmedCount":null,"jensenScore":2743.528165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.37814712796048,"pubTatorScore":2.2482760554232675,"self":"https://pharos.nih.gov/idg/api/v1/targets(3650)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":498,"href":"https://pharos.nih.gov/idg/api/v1/targets(3650)/properties"},"_links":{"count":1351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3650)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(3650)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3650)/publications"},"_namespace":null},{"id":3651,"version":2,"created":1554879942000,"modified":1554879943000,"deprecated":false,"name":"Lymphocyte antigen 6 complex locus protein G6c","accession":"O95867","gene":"LY6G6C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0757786237297773,"antibodyCount":74,"monoclonalCount":5,"pubmedCount":null,"jensenScore":11.008382,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.50095688214899,"pubTatorScore":-0.5093056708330032,"self":"https://pharos.nih.gov/idg/api/v1/targets(3651)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(3651)/properties"},"_links":{"count":674,"href":"https://pharos.nih.gov/idg/api/v1/targets(3651)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3651)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3651)/publications"},"_namespace":null},{"id":3652,"version":2,"created":1554879944000,"modified":1554879949000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase G","accession":"Q13427","gene":"PPIG","description":"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.694068525536687,"antibodyCount":219,"monoclonalCount":52,"pubmedCount":null,"jensenScore":4420.985987,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.226430968980864,"pubTatorScore":2.4360355949359405,"self":"https://pharos.nih.gov/idg/api/v1/targets(3652)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(3652)/properties"},"_links":{"count":1175,"href":"https://pharos.nih.gov/idg/api/v1/targets(3652)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3652)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3652)/publications"},"_namespace":null},{"id":3653,"version":2,"created":1554879950000,"modified":1554879952000,"deprecated":false,"name":"Megakaryocyte and platelet inhibitory receptor G6b","accession":"O95866","gene":"MPIG6B","description":"Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0042872534741532,"antibodyCount":53,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.789791,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.5064298293604574,"self":"https://pharos.nih.gov/idg/api/v1/targets(3653)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(3653)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(3653)/links"},"_synonyms":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(3653)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3653)/publications"},"_namespace":null},{"id":3654,"version":3,"created":1554879953000,"modified":1555034909000,"deprecated":false,"name":"DNA repair protein XRCC4","accession":"Q13426","gene":"XRCC4","description":"Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3835244861114346,"antibodyCount":322,"monoclonalCount":30,"pubmedCount":null,"jensenScore":232.856354,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":45.75713244801057,"pubTatorScore":2.3295592197923187,"self":"https://pharos.nih.gov/idg/api/v1/targets(3654)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":613,"href":"https://pharos.nih.gov/idg/api/v1/targets(3654)/properties"},"_links":{"count":1304,"href":"https://pharos.nih.gov/idg/api/v1/targets(3654)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3654)/synonyms"},"_publications":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3654)/publications"},"_namespace":null},{"id":3655,"version":2,"created":1554879958000,"modified":1554879961000,"deprecated":false,"name":"Beta-2-syntrophin","accession":"Q13425","gene":"SNTB2","description":"Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2004188629068353,"antibodyCount":121,"monoclonalCount":12,"pubmedCount":null,"jensenScore":14.71002,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.534264237750044,"pubTatorScore":0.6283888278633626,"self":"https://pharos.nih.gov/idg/api/v1/targets(3655)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3655)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(3655)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3655)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(3655)/publications"},"_namespace":null},{"id":3656,"version":3,"created":1554879962000,"modified":1555034912000,"deprecated":false,"name":"N(G),N(G)-dimethylarginine dimethylaminohydrolase 2","accession":"O95865","gene":"DDAH2","description":"Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.118599364225763,"antibodyCount":183,"monoclonalCount":20,"pubmedCount":null,"jensenScore":122.464511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":34.27040647756705,"pubTatorScore":1.9369583299037296,"self":"https://pharos.nih.gov/idg/api/v1/targets(3656)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(3656)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(3656)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3656)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3656)/publications"},"_namespace":null},{"id":3657,"version":3,"created":1554879965000,"modified":1555034913000,"deprecated":false,"name":"Mitotic spindle-associated MMXD complex subunit MIP18","accession":"Q9Y3D0","gene":"FAM96B","description":"Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8267671275865629,"antibodyCount":108,"monoclonalCount":5,"pubmedCount":null,"jensenScore":5.825303,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.702927895481427,"pubTatorScore":0.837047063446548,"self":"https://pharos.nih.gov/idg/api/v1/targets(3657)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(3657)/properties"},"_links":{"count":1080,"href":"https://pharos.nih.gov/idg/api/v1/targets(3657)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3657)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3657)/publications"},"_namespace":null},{"id":3658,"version":2,"created":1554879969000,"modified":1554879972000,"deprecated":false,"name":"Unconventional myosin-IXa","accession":"B2RTY4","gene":"MYO9A","description":"Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8298484274349304,"antibodyCount":21,"monoclonalCount":9,"pubmedCount":null,"jensenScore":8.760125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.971552746211614,"pubTatorScore":0.7606109383977046,"self":"https://pharos.nih.gov/idg/api/v1/targets(3658)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(3658)/properties"},"_links":{"count":1096,"href":"https://pharos.nih.gov/idg/api/v1/targets(3658)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3658)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3658)/publications"},"_namespace":null},{"id":3659,"version":2,"created":1554879973000,"modified":1554879973000,"deprecated":false,"name":"EF-hand calcium-binding domain-containing protein 9","accession":"A8MZ26","gene":"EFCAB9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.252155144118177,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3659)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3659)/properties"},"_links":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(3659)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3659)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3659)/publications"},"_namespace":null},{"id":3660,"version":2,"created":1554879973000,"modified":1554879977000,"deprecated":false,"name":"PHD finger protein 10","accession":"Q8WUB8","gene":"PHF10","description":"Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.0943012937775338,"antibodyCount":53,"monoclonalCount":4,"pubmedCount":null,"jensenScore":12.491052,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.54615211930292,"pubTatorScore":1.053188771013427,"self":"https://pharos.nih.gov/idg/api/v1/targets(3660)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(3660)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(3660)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3660)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3660)/publications"},"_namespace":null},{"id":3661,"version":3,"created":1554879978000,"modified":1555034915000,"deprecated":false,"name":"N-acetylaspartate synthetase","accession":"Q8N9F0","gene":"NAT8L","description":"Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2748722742444838,"antibodyCount":64,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.09839,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.63013619564058,"pubTatorScore":1.302835767694414,"self":"https://pharos.nih.gov/idg/api/v1/targets(3661)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3661)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(3661)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3661)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3661)/publications"},"_namespace":null},{"id":3662,"version":3,"created":1554879980000,"modified":1555034917000,"deprecated":false,"name":"Protein Smaug homolog 2","accession":"Q5PRF9","gene":"SAMD4B","description":"Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9328118593466832,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.61212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":36.055743087741924,"pubTatorScore":0.6842467175639678,"self":"https://pharos.nih.gov/idg/api/v1/targets(3662)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(3662)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(3662)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3662)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3662)/publications"},"_namespace":null},{"id":3663,"version":2,"created":1554879984000,"modified":1554879986000,"deprecated":false,"name":"Sodium/hydrogen exchanger 9B2","accession":"Q86UD5","gene":"SLC9B2","description":"Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.2195575311345457,"antibodyCount":126,"monoclonalCount":19,"pubmedCount":null,"jensenScore":18.847526,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.32527529416315,"pubTatorScore":1.10866164688811,"self":"https://pharos.nih.gov/idg/api/v1/targets(3663)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(3663)/properties"},"_links":{"count":962,"href":"https://pharos.nih.gov/idg/api/v1/targets(3663)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3663)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3663)/publications"},"_namespace":null},{"id":3664,"version":3,"created":1554879987000,"modified":1555034919000,"deprecated":false,"name":"40S ribosomal protein S27","accession":"P42677","gene":"RPS27","description":"Component of the small ribosomal subunit (PubMed:8706699). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.4831976534288067,"antibodyCount":162,"monoclonalCount":54,"pubmedCount":null,"jensenScore":31.89404,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":39.14613657625649,"pubTatorScore":1.5344511510215728,"self":"https://pharos.nih.gov/idg/api/v1/targets(3664)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3664)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(3664)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(3664)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3664)/publications"},"_namespace":null},{"id":3665,"version":2,"created":1554879992000,"modified":1554879995000,"deprecated":false,"name":"Mitochondrial import inner membrane translocase subunit TIM16","accession":"Q9Y3D7","gene":"PAM16","description":"Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.3639616755851596,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":227.637089,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.66635730594235,"pubTatorScore":1.2387030976532454,"self":"https://pharos.nih.gov/idg/api/v1/targets(3665)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(3665)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(3665)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3665)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3665)/publications"},"_namespace":null},{"id":3666,"version":2,"created":1554879995000,"modified":1554879998000,"deprecated":false,"name":"Zinc finger protein 329","accession":"Q86UD4","gene":"ZNF329","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":119,"monoclonalCount":17,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.697332196206094,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3666)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(3666)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(3666)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3666)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3666)/publications"},"_namespace":null},{"id":3667,"version":3,"created":1554879998000,"modified":1555034922000,"deprecated":false,"name":"Mitochondrial fission 1 protein","accession":"Q9Y3D6","gene":"FIS1","description":"Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.195724232870906,"antibodyCount":224,"monoclonalCount":57,"pubmedCount":null,"jensenScore":143.367132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":38.179615107120604,"pubTatorScore":1.8307692129788034,"self":"https://pharos.nih.gov/idg/api/v1/targets(3667)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(3667)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3667)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3667)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3667)/publications"},"_namespace":null},{"id":3668,"version":2,"created":1554880003000,"modified":1554880006000,"deprecated":false,"name":"28S ribosomal protein S23, mitochondrial","accession":"Q9Y3D9","gene":"MRPS23","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.33935678022549975,"antibodyCount":98,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.98449058569914,"pubTatorScore":-0.3467874862246563,"self":"https://pharos.nih.gov/idg/api/v1/targets(3668)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(3668)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3668)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3668)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3668)/publications"},"_namespace":null},{"id":3669,"version":2,"created":1554880007000,"modified":1554880009000,"deprecated":false,"name":"E3 ubiquitin-protein ligase MARCH3","accession":"Q86UD3","gene":"MARCH3","description":"E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4489950158135572,"antibodyCount":135,"monoclonalCount":19,"pubmedCount":null,"jensenScore":27.842321,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.64850436461923,"pubTatorScore":2.025578917861205,"self":"https://pharos.nih.gov/idg/api/v1/targets(3669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(3669)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(3669)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3669)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3669)/publications"},"_namespace":null},{"id":3670,"version":2,"created":1554880009000,"modified":1554880013000,"deprecated":false,"name":"Megakaryocyte-associated tyrosine-protein kinase","accession":"P42679","gene":"MATK","description":"Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.985962746149765,"antibodyCount":265,"monoclonalCount":53,"pubmedCount":null,"jensenScore":792.260611,"patentCount":43586,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.396536683266525,"pubTatorScore":2.760876023182745,"self":"https://pharos.nih.gov/idg/api/v1/targets(3670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(3670)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(3670)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3670)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3670)/publications"},"_namespace":null},{"id":3671,"version":2,"created":1554880014000,"modified":1554880018000,"deprecated":false,"name":"Mast cell carboxypeptidase A","accession":"P15088","gene":"CPA3","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.7297244415169606,"antibodyCount":151,"monoclonalCount":9,"pubmedCount":null,"jensenScore":50.209375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.931894112823564,"pubTatorScore":1.3609324625248123,"self":"https://pharos.nih.gov/idg/api/v1/targets(3671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(3671)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(3671)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3671)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3671)/publications"},"_namespace":null},{"id":3672,"version":2,"created":1554880019000,"modified":1554880021000,"deprecated":false,"name":"Adenylate kinase isoenzyme 6","accession":"Q9Y3D8","gene":"AK6","description":"Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.1885865441882455,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":223.131644,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.677807582018905,"pubTatorScore":0.6895625231340565,"self":"https://pharos.nih.gov/idg/api/v1/targets(3672)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(3672)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(3672)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3672)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3672)/publications"},"_namespace":null},{"id":3673,"version":2,"created":1554880022000,"modified":1554880025000,"deprecated":false,"name":"28S ribosomal protein S16, mitochondrial","accession":"Q9Y3D3","gene":"MRPS16","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.33243845904701635,"antibodyCount":61,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.700865,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.447918581279815,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(3673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3673)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(3673)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3673)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3673)/publications"},"_namespace":null},{"id":3674,"version":2,"created":1554880026000,"modified":1554880028000,"deprecated":false,"name":"Out at first protein homolog","accession":"Q86UD1","gene":"OAF","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7918742667142704,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":60.561177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.800370467421136,"pubTatorScore":0.5835765478692101,"self":"https://pharos.nih.gov/idg/api/v1/targets(3674)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(3674)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(3674)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3674)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3674)/publications"},"_namespace":null},{"id":3675,"version":2,"created":1554880028000,"modified":1554880031000,"deprecated":false,"name":"Suppressor APC domain-containing protein 2","accession":"Q86UD0","gene":"SAPCD2","description":"Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.106549732666401,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.62133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.50903487255252,"pubTatorScore":1.0212071668182023,"self":"https://pharos.nih.gov/idg/api/v1/targets(3675)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(3675)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(3675)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(3675)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3675)/publications"},"_namespace":null},{"id":3676,"version":3,"created":1554880032000,"modified":1555034924000,"deprecated":false,"name":"Methionine-R-sulfoxide reductase B2, mitochondrial","accession":"Q9Y3D2","gene":"MSRB2","description":"Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.848558130880794,"antibodyCount":120,"monoclonalCount":25,"pubmedCount":null,"jensenScore":71.480105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":35.1177836062055,"pubTatorScore":1.7456261672586837,"self":"https://pharos.nih.gov/idg/api/v1/targets(3676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(3676)/properties"},"_links":{"count":1004,"href":"https://pharos.nih.gov/idg/api/v1/targets(3676)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3676)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3676)/publications"},"_namespace":null},{"id":3677,"version":2,"created":1554880035000,"modified":1554880054000,"deprecated":false,"name":"Carboxypeptidase B","accession":"P15086","gene":"CPB1","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.9769616529771348,"antibodyCount":228,"monoclonalCount":32,"pubmedCount":null,"jensenScore":882.970133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.333726553275973,"pubTatorScore":2.272397270934039,"self":"https://pharos.nih.gov/idg/api/v1/targets(3677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3677)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(3677)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3677)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3677)/publications"},"_namespace":null},{"id":3678,"version":3,"created":1554880055000,"modified":1555034926000,"deprecated":false,"name":"28S ribosomal protein S18c, mitochondrial","accession":"Q9Y3D5","gene":"MRPS18C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":42,"knowledgeAvailability":30.733068580478047,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3678)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(3678)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(3678)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3678)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3678)/publications"},"_namespace":null},{"id":3679,"version":2,"created":1554880058000,"modified":1554880060000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 9B","accession":"Q9HBM6","gene":"TAF9B","description":"Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.383715680780595,"antibodyCount":105,"monoclonalCount":17,"pubmedCount":null,"jensenScore":23.532515,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.90967965141885,"pubTatorScore":0.8073899684299451,"self":"https://pharos.nih.gov/idg/api/v1/targets(3679)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(3679)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(3679)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3679)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3679)/publications"},"_namespace":null},{"id":3680,"version":2,"created":1554880061000,"modified":1554880069000,"deprecated":false,"name":"Carboxypeptidase A1","accession":"P15085","gene":"CPA1","description":"Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.9554077198045032,"antibodyCount":265,"monoclonalCount":62,"pubmedCount":null,"jensenScore":84.125284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.426942539556105,"pubTatorScore":2.248671732036702,"self":"https://pharos.nih.gov/idg/api/v1/targets(3680)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3680)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(3680)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3680)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3680)/publications"},"_namespace":null},{"id":3681,"version":2,"created":1554880070000,"modified":1554880071000,"deprecated":false,"name":"Putative zinc finger and SCAN domain-containing protein 5C","accession":"A6NGD5","gene":"ZSCAN5C","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3681)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(3681)/properties"},"_links":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(3681)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3681)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3681)/publications"},"_namespace":null},{"id":3682,"version":3,"created":1554880071000,"modified":1555034927000,"deprecated":false,"name":"Vezatin","accession":"Q9HBM0","gene":"VEZT","description":"Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0341402511178854,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.029872,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.65547932811676,"pubTatorScore":0.9136877297840053,"self":"https://pharos.nih.gov/idg/api/v1/targets(3682)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(3682)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(3682)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3682)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3682)/publications"},"_namespace":null},{"id":3683,"version":3,"created":1554880074000,"modified":1555034928000,"deprecated":false,"name":"Kinetochore protein Spc25","accession":"Q9HBM1","gene":"SPC25","description":"Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2632414311554608,"antibodyCount":132,"monoclonalCount":23,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":31.09735204494305,"pubTatorScore":1.2725874181305143,"self":"https://pharos.nih.gov/idg/api/v1/targets(3683)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(3683)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(3683)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3683)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3683)/publications"},"_namespace":null},{"id":3684,"version":2,"created":1554880077000,"modified":1554880079000,"deprecated":false,"name":"PWWP domain-containing protein MUM1L1","accession":"Q5H9M0","gene":"MUM1L1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4357285699957319,"antibodyCount":71,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.268249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.380738188809314,"pubTatorScore":-0.6320238351265371,"self":"https://pharos.nih.gov/idg/api/v1/targets(3684)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3684)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(3684)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3684)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3684)/publications"},"_namespace":null},{"id":3685,"version":2,"created":1554880080000,"modified":1554880082000,"deprecated":false,"name":"Protein tyrosine phosphatase receptor type C-associated protein","accession":"Q14761","gene":"PTPRCAP","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0069692855853207,"antibodyCount":90,"monoclonalCount":6,"pubmedCount":null,"jensenScore":13.480554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.04495981734948,"pubTatorScore":0.99673047167752,"self":"https://pharos.nih.gov/idg/api/v1/targets(3685)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3685)/properties"},"_links":{"count":804,"href":"https://pharos.nih.gov/idg/api/v1/targets(3685)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3685)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3685)/publications"},"_namespace":null},{"id":3686,"version":2,"created":1554880083000,"modified":1554880084000,"deprecated":false,"name":"TBC1 domain family member 26","accession":"Q86UD7","gene":"TBC1D26","description":"May act as a GTPase-activating protein for Rab family protein(s).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.870261473898836,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3686)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3686)/properties"},"_links":{"count":691,"href":"https://pharos.nih.gov/idg/api/v1/targets(3686)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3686)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3686)/publications"},"_namespace":null},{"id":3687,"version":2,"created":1554880085000,"modified":1554880086000,"deprecated":false,"name":"Transmembrane protein 14B","accession":"Q9NUH8","gene":"TMEM14B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.8,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.727904689935446,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3687)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(3687)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(3687)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3687)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3687)/publications"},"_namespace":null},{"id":3688,"version":2,"created":1554880087000,"modified":1554880090000,"deprecated":false,"name":"Splicing factor 3B subunit 2","accession":"Q13435","gene":"SF3B2","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3222856730320154,"antibodyCount":163,"monoclonalCount":29,"pubmedCount":null,"jensenScore":20.684226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.237269023899856,"pubTatorScore":1.1106297376126684,"self":"https://pharos.nih.gov/idg/api/v1/targets(3688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(3688)/properties"},"_links":{"count":1190,"href":"https://pharos.nih.gov/idg/api/v1/targets(3688)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3688)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3688)/publications"},"_namespace":null},{"id":3689,"version":2,"created":1554880091000,"modified":1554880094000,"deprecated":false,"name":"Latent-transforming growth factor beta-binding protein 1","accession":"Q14766","gene":"LTBP1","description":"May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9759011826179431,"antibodyCount":128,"monoclonalCount":24,"pubmedCount":null,"jensenScore":101.452675,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.50142477307094,"pubTatorScore":1.8552928941243942,"self":"https://pharos.nih.gov/idg/api/v1/targets(3689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":480,"href":"https://pharos.nih.gov/idg/api/v1/targets(3689)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(3689)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3689)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3689)/publications"},"_namespace":null},{"id":3690,"version":3,"created":1554880095000,"modified":1555034930000,"deprecated":false,"name":"Signal transducer and activator of transcription 4","accession":"Q14765","gene":"STAT4","description":"Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5138218111088926,"antibodyCount":790,"monoclonalCount":174,"pubmedCount":null,"jensenScore":320.399519,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":47.44221846189274,"pubTatorScore":2.488685824518355,"self":"https://pharos.nih.gov/idg/api/v1/targets(3690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":600,"href":"https://pharos.nih.gov/idg/api/v1/targets(3690)/properties"},"_links":{"count":1238,"href":"https://pharos.nih.gov/idg/api/v1/targets(3690)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3690)/synonyms"},"_publications":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3690)/publications"},"_namespace":null},{"id":3691,"version":2,"created":1554880102000,"modified":1554880102000,"deprecated":false,"name":"Putative E3 ubiquitin-protein ligase makorin-4","accession":"Q13434","gene":"MKRN4P","description":"May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.808056494365585,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3691)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3691)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3691)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3691)/publications"},"_namespace":null},{"id":3692,"version":3,"created":1554880102000,"modified":1555034932000,"deprecated":false,"name":"Sentrin-specific protease 2","accession":"Q9HC62","gene":"SENP2","description":"Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.2579450943855736,"antibodyCount":478,"monoclonalCount":258,"pubmedCount":null,"jensenScore":1.433333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.39735760678159,"pubTatorScore":1.4910381220028133,"self":"https://pharos.nih.gov/idg/api/v1/targets(3692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(3692)/properties"},"_links":{"count":993,"href":"https://pharos.nih.gov/idg/api/v1/targets(3692)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3692)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3692)/publications"},"_namespace":null},{"id":3693,"version":2,"created":1554880106000,"modified":1554880107000,"deprecated":false,"name":"Uncharacterized protein C6orf47","accession":"O95873","gene":"C6orf47","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.49732463832626667,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.610119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.208340930354073,"self":"https://pharos.nih.gov/idg/api/v1/targets(3693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(3693)/properties"},"_links":{"count":729,"href":"https://pharos.nih.gov/idg/api/v1/targets(3693)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3693)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3693)/publications"},"_namespace":null},{"id":3694,"version":2,"created":1554880108000,"modified":1554880111000,"deprecated":false,"name":"Zinc transporter ZIP6","accession":"Q13433","gene":"SLC39A6","description":"May act as a zinc-influx transporter.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.6666307241379057,"antibodyCount":172,"monoclonalCount":0,"pubmedCount":null,"jensenScore":50.000126,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.92087486243834,"pubTatorScore":1.6997705220486343,"self":"https://pharos.nih.gov/idg/api/v1/targets(3694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(3694)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(3694)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3694)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3694)/publications"},"_namespace":null},{"id":3695,"version":3,"created":1554880112000,"modified":1555034934000,"deprecated":false,"name":"Probable threonine protease PRSS50","accession":"Q9UI38","gene":"PRSS50","description":"May be involved in proteolysis through its threonine endopeptidase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.830723900810007,"antibodyCount":99,"monoclonalCount":30,"pubmedCount":null,"jensenScore":69.183354,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":23.100400372966064,"pubTatorScore":1.5196613291742662,"self":"https://pharos.nih.gov/idg/api/v1/targets(3695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3695)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(3695)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3695)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3695)/publications"},"_namespace":null},{"id":3696,"version":3,"created":1554880114000,"modified":1555034936000,"deprecated":false,"name":"Major vault protein","accession":"Q14764","gene":"MVP","description":"Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.449080995325452,"antibodyCount":449,"monoclonalCount":251,"pubmedCount":null,"jensenScore":251.865177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":41.78866356109588,"pubTatorScore":2.3475567788416725,"self":"https://pharos.nih.gov/idg/api/v1/targets(3696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(3696)/properties"},"_links":{"count":1213,"href":"https://pharos.nih.gov/idg/api/v1/targets(3696)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3696)/synonyms"},"_publications":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3696)/publications"},"_namespace":null},{"id":3697,"version":3,"created":1554880121000,"modified":1555034938000,"deprecated":false,"name":"G patch domain and ankyrin repeat-containing protein 1","accession":"O95872","gene":"GPANK1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4533884964323733,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":24.981239,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":31.558944301792714,"pubTatorScore":1.6056078905626678,"self":"https://pharos.nih.gov/idg/api/v1/targets(3697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(3697)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(3697)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3697)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3697)/publications"},"_namespace":null},{"id":3698,"version":2,"created":1554880123000,"modified":1554880125000,"deprecated":false,"name":"Homeobox protein BarH-like 1","accession":"Q9HBU1","gene":"BARX1","description":"Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.512021716664765,"antibodyCount":202,"monoclonalCount":33,"pubmedCount":null,"jensenScore":31.88122,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.36237397197881,"pubTatorScore":0.9339159041110415,"self":"https://pharos.nih.gov/idg/api/v1/targets(3698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(3698)/properties"},"_links":{"count":676,"href":"https://pharos.nih.gov/idg/api/v1/targets(3698)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3698)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3698)/publications"},"_namespace":null},{"id":3699,"version":2,"created":1554880126000,"modified":1554880130000,"deprecated":false,"name":"Heat shock-related 70 kDa protein 2","accession":"P54652","gene":"HSPA2","description":"Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.986550556644483,"antibodyCount":162,"monoclonalCount":53,"pubmedCount":null,"jensenScore":104.28784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.08561695509499,"pubTatorScore":1.9743247769398165,"self":"https://pharos.nih.gov/idg/api/v1/targets(3699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(3699)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(3699)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(3699)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3699)/publications"},"_namespace":null},{"id":3700,"version":3,"created":1554880131000,"modified":1555034939000,"deprecated":false,"name":"Protein unc-119 homolog A","accession":"Q13432","gene":"UNC119","description":"Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.0446740719616407,"antibodyCount":42,"monoclonalCount":10,"pubmedCount":null,"jensenScore":109.463923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":38.475428994747624,"pubTatorScore":1.2198899965294787,"self":"https://pharos.nih.gov/idg/api/v1/targets(3700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(3700)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(3700)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3700)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3700)/publications"},"_namespace":null},{"id":3701,"version":3,"created":1554880136000,"modified":1555034941000,"deprecated":false,"name":"Golgin subfamily A member 4","accession":"Q13439","gene":"GOLGA4","description":"May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.704768590946151,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":46.730736,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":40.54992627471105,"pubTatorScore":1.6509079402267097,"self":"https://pharos.nih.gov/idg/api/v1/targets(3701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(3701)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(3701)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3701)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3701)/publications"},"_namespace":null},{"id":3702,"version":2,"created":1554880140000,"modified":1554880141000,"deprecated":false,"name":"Uncharacterized protein C19orf47","accession":"Q8N9M1","gene":"C19orf47","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3702)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(3702)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3702)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3702)/publications"},"_namespace":null},{"id":3703,"version":3,"created":1554880142000,"modified":1555034947000,"deprecated":false,"name":"Protein OS-9","accession":"Q13438","gene":"OS9","description":"Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7607360668905323,"antibodyCount":170,"monoclonalCount":10,"pubmedCount":null,"jensenScore":57.065546,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":80,"knowledgeAvailability":39.14209937485762,"pubTatorScore":1.5913786331426507,"self":"https://pharos.nih.gov/idg/api/v1/targets(3703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(3703)/properties"},"_links":{"count":1215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3703)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(3703)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3703)/publications"},"_namespace":null},{"id":3704,"version":3,"created":1554880146000,"modified":1555034949000,"deprecated":false,"name":"Histone deacetylase 7","accession":"Q8WUI4","gene":"HDAC7","description":"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-2.024749759937953,"antibodyCount":477,"monoclonalCount":41,"pubmedCount":null,"jensenScore":107.620647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":45.009479177809766,"pubTatorScore":1.8768135241585877,"self":"https://pharos.nih.gov/idg/api/v1/targets(3704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(3704)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3704)/links"},"_synonyms":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3704)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3704)/publications"},"_namespace":null},{"id":3705,"version":2,"created":1554880155000,"modified":1554880158000,"deprecated":false,"name":"WD repeat-containing and planar cell polarity effector protein fritz homolog","accession":"O95876","gene":"WDPCP","description":"Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8401891408910651,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.07889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.437508481364624,"pubTatorScore":0.9760985932985099,"self":"https://pharos.nih.gov/idg/api/v1/targets(3705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(3705)/properties"},"_links":{"count":929,"href":"https://pharos.nih.gov/idg/api/v1/targets(3705)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3705)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3705)/publications"},"_namespace":null},{"id":3706,"version":2,"created":1554880159000,"modified":1554880162000,"deprecated":false,"name":"Latent-transforming growth factor beta-binding protein 2","accession":"Q14767","gene":"LTBP2","description":"May play an integral structural role in elastic-fiber architectural organization and/or assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2272080133967518,"antibodyCount":100,"monoclonalCount":37,"pubmedCount":null,"jensenScore":18.233798,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.383659346305066,"pubTatorScore":1.743568531613775,"self":"https://pharos.nih.gov/idg/api/v1/targets(3706)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(3706)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(3706)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3706)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3706)/publications"},"_namespace":null},{"id":3707,"version":2,"created":1554880163000,"modified":1554880164000,"deprecated":false,"name":"Transmembrane protein 102","accession":"Q8N9M5","gene":"TMEM102","description":"Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2201392610795396,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.513626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.320399837617494,"pubTatorScore":-0.003634576617869096,"self":"https://pharos.nih.gov/idg/api/v1/targets(3707)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3707)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(3707)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3707)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3707)/publications"},"_namespace":null},{"id":3708,"version":2,"created":1554880165000,"modified":1554880165000,"deprecated":false,"name":"Leucine-twenty homeobox","accession":"A8MZ59","gene":"LEUTX","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.13300635777727365,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.406923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.76112959476879,"pubTatorScore":0.03856333836883654,"self":"https://pharos.nih.gov/idg/api/v1/targets(3708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3708)/properties"},"_links":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3708)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(3708)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3708)/publications"},"_namespace":null},{"id":3709,"version":2,"created":1554880166000,"modified":1554880169000,"deprecated":false,"name":"ATP-binding cassette sub-family A member 12","accession":"Q86UK0","gene":"ABCA12","description":"Probable transporter involved in lipid homeostasis.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.0587256554874847,"antibodyCount":66,"monoclonalCount":1,"pubmedCount":null,"jensenScore":115.543774,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.8386698331409,"pubTatorScore":2.2846356409081108,"self":"https://pharos.nih.gov/idg/api/v1/targets(3709)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(3709)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(3709)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3709)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3709)/publications"},"_namespace":null},{"id":3710,"version":2,"created":1554880169000,"modified":1554880172000,"deprecated":false,"name":"Protein ABHD16A","accession":"O95870","gene":"ABHD16A","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.6908433438666068,"antibodyCount":72,"monoclonalCount":2,"pubmedCount":null,"jensenScore":46.72537,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.934632373931194,"pubTatorScore":0.7190366293015521,"self":"https://pharos.nih.gov/idg/api/v1/targets(3710)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(3710)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(3710)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3710)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3710)/publications"},"_namespace":null},{"id":3711,"version":3,"created":1554880173000,"modified":1555034951000,"deprecated":false,"name":"Armadillo repeat-containing X-linked protein 4","accession":"Q5H9R4","gene":"ARMCX4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.4913616938342726,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.032258,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":17.280014521123544,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(3711)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(3711)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3711)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3711)/publications"},"_namespace":null},{"id":3712,"version":2,"created":1554880177000,"modified":1554880179000,"deprecated":false,"name":"E3 ubiquitin-protein ligase ZNF598","accession":"Q86UK7","gene":"ZNF598","description":"E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4393326981732075,"antibodyCount":109,"monoclonalCount":6,"pubmedCount":null,"jensenScore":2.276786,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.186802374873437,"pubTatorScore":-0.405765504109289,"self":"https://pharos.nih.gov/idg/api/v1/targets(3712)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(3712)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(3712)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3712)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3712)/publications"},"_namespace":null},{"id":3713,"version":2,"created":1554880180000,"modified":1554880180000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 8-like protein 1","accession":"A6NGE4","gene":"DCAF8L1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.686583131713462,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3713)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3713)/properties"},"_links":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(3713)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(3713)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3713)/publications"},"_namespace":null},{"id":3714,"version":3,"created":1554880180000,"modified":1555034952000,"deprecated":false,"name":"POTE ankyrin domain family member C","accession":"B2RU33","gene":"POTEC","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":6.398003412419402,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3714)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3714)/properties"},"_links":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3714)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(3714)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3714)/publications"},"_namespace":null},{"id":3715,"version":3,"created":1554880181000,"modified":1555034952000,"deprecated":false,"name":"Limbin","accession":"Q86UK5","gene":"EVC2","description":"Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.512150642889897,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":313.994098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.60159830331615,"pubTatorScore":1.5819189644160347,"self":"https://pharos.nih.gov/idg/api/v1/targets(3715)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(3715)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(3715)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3715)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3715)/publications"},"_namespace":null},{"id":3716,"version":3,"created":1554880184000,"modified":1555034953000,"deprecated":false,"name":"Zinc finger protein 287","accession":"Q9HBT7","gene":"ZNF287","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":164,"monoclonalCount":15,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":27.16528726238931,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3716)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(3716)/properties"},"_links":{"count":842,"href":"https://pharos.nih.gov/idg/api/v1/targets(3716)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3716)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3716)/publications"},"_namespace":null},{"id":3717,"version":3,"created":1554880187000,"modified":1555034955000,"deprecated":false,"name":"rRNA methyltransferase 2, mitochondrial","accession":"Q9UI43","gene":"MRM2","description":"S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4132997484466507,"antibodyCount":37,"monoclonalCount":10,"pubmedCount":null,"jensenScore":23.711243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":0.0,"pubTatorScore":0.7481879494536074,"self":"https://pharos.nih.gov/idg/api/v1/targets(3717)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3717)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(3717)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3717)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3717)/publications"},"_namespace":null},{"id":3718,"version":2,"created":1554880189000,"modified":1554880192000,"deprecated":false,"name":"WAP four-disulfide core domain protein 1","accession":"Q9HC57","gene":"WFDC1","description":"Has growth inhibitory activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9459238261587866,"antibodyCount":127,"monoclonalCount":2,"pubmedCount":null,"jensenScore":87.909037,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.712113585928652,"pubTatorScore":1.7348791630654292,"self":"https://pharos.nih.gov/idg/api/v1/targets(3718)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3718)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(3718)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3718)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3718)/publications"},"_namespace":null},{"id":3719,"version":2,"created":1554880192000,"modified":1554880194000,"deprecated":false,"name":"Cadherin-20","accession":"Q9HBT6","gene":"CDH20","description":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7155123039916548,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.089108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.296452224315317,"pubTatorScore":0.10833936198506207,"self":"https://pharos.nih.gov/idg/api/v1/targets(3719)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(3719)/properties"},"_links":{"count":737,"href":"https://pharos.nih.gov/idg/api/v1/targets(3719)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3719)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3719)/publications"},"_namespace":null},{"id":3720,"version":3,"created":1554880195000,"modified":1555034956000,"deprecated":false,"name":"Protocadherin-9","accession":"Q9HC56","gene":"PCDH9","description":"Potential calcium-dependent cell-adhesion protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1613788163022098,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.213729,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":40.78450155384397,"pubTatorScore":0.9432608342743611,"self":"https://pharos.nih.gov/idg/api/v1/targets(3720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(3720)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(3720)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3720)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3720)/publications"},"_namespace":null},{"id":3721,"version":2,"created":1554880198000,"modified":1554880200000,"deprecated":false,"name":"Carboxypeptidase A4","accession":"Q9UI42","gene":"CPA4","description":"Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6948395901039623,"antibodyCount":61,"monoclonalCount":22,"pubmedCount":null,"jensenScore":48.278313,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.264591428155423,"pubTatorScore":1.3270594847605521,"self":"https://pharos.nih.gov/idg/api/v1/targets(3721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(3721)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(3721)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3721)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3721)/publications"},"_namespace":null},{"id":3722,"version":2,"created":1554880201000,"modified":1554880203000,"deprecated":false,"name":"Sodium/potassium/calcium exchanger 3","accession":"Q9HC58","gene":"SLC24A3","description":"Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.1227370108721642,"antibodyCount":86,"monoclonalCount":1,"pubmedCount":null,"jensenScore":13.019509,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.0401933383016,"pubTatorScore":1.058835563846098,"self":"https://pharos.nih.gov/idg/api/v1/targets(3722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(3722)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(3722)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3722)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3722)/publications"},"_namespace":null},{"id":3723,"version":2,"created":1554880204000,"modified":1554880206000,"deprecated":false,"name":"Sodium/potassium/calcium exchanger 2","accession":"Q9UI40","gene":"SLC24A2","description":"Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.3960476819017091,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":25.706446,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.011748095056504,"pubTatorScore":1.4690384606288798,"self":"https://pharos.nih.gov/idg/api/v1/targets(3723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(3723)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(3723)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3723)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3723)/publications"},"_namespace":null},{"id":3724,"version":3,"created":1554880206000,"modified":1555034957000,"deprecated":false,"name":"Zinc finger protein 286A","accession":"Q9HBT8","gene":"ZNF286A","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":164,"monoclonalCount":57,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":25.81866939019487,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(3724)/properties"},"_links":{"count":775,"href":"https://pharos.nih.gov/idg/api/v1/targets(3724)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3724)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3724)/publications"},"_namespace":null},{"id":3725,"version":3,"created":1554880209000,"modified":1555034958000,"deprecated":false,"name":"28 kDa heat- and acid-stable phosphoprotein","accession":"Q13442","gene":"PDAP1","description":"Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.32975217033369353,"antibodyCount":161,"monoclonalCount":6,"pubmedCount":null,"jensenScore":2.222704,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.055001220476946,"pubTatorScore":1.8465678146388262,"self":"https://pharos.nih.gov/idg/api/v1/targets(3725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(3725)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(3725)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3725)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3725)/publications"},"_namespace":null},{"id":3726,"version":2,"created":1554880212000,"modified":1554880213000,"deprecated":false,"name":"Intercellular adhesion molecule 4","accession":"Q14773","gene":"ICAM4","description":"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4343004332223406,"antibodyCount":158,"monoclonalCount":22,"pubmedCount":null,"jensenScore":28.14033,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.88857035232969,"pubTatorScore":1.532216565312909,"self":"https://pharos.nih.gov/idg/api/v1/targets(3726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(3726)/properties"},"_links":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(3726)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3726)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3726)/publications"},"_namespace":null},{"id":3727,"version":3,"created":1554880213000,"modified":1555034962000,"deprecated":false,"name":"Catenin alpha-3","accession":"Q9UI47","gene":"CTNNA3","description":"May be involved in formation of stretch-resistant cell-cell adhesion complexes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6301732194834748,"antibodyCount":140,"monoclonalCount":55,"pubmedCount":null,"jensenScore":40.40085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":39.1122768383665,"pubTatorScore":1.535536143277953,"self":"https://pharos.nih.gov/idg/api/v1/targets(3727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(3727)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(3727)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3727)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3727)/publications"},"_namespace":null},{"id":3728,"version":2,"created":1554880217000,"modified":1554880220000,"deprecated":false,"name":"Dynein intermediate chain 1, axonemal","accession":"Q9UI46","gene":"DNAI1","description":"Part of the dynein complex of respiratory cilia.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9065436427107803,"antibodyCount":160,"monoclonalCount":29,"pubmedCount":null,"jensenScore":78.865834,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.440107239965585,"pubTatorScore":1.5932059588902543,"self":"https://pharos.nih.gov/idg/api/v1/targets(3728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(3728)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(3728)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3728)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3728)/publications"},"_namespace":null},{"id":3729,"version":2,"created":1554880221000,"modified":1554880224000,"deprecated":false,"name":"Chromobox protein homolog 8","accession":"Q9HC52","gene":"CBX8","description":"Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.2753670086025544,"antibodyCount":505,"monoclonalCount":196,"pubmedCount":null,"jensenScore":183.42648,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.33384722805622,"pubTatorScore":3.0459361931990943,"self":"https://pharos.nih.gov/idg/api/v1/targets(3729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(3729)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(3729)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3729)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(3729)/publications"},"_namespace":null},{"id":3730,"version":3,"created":1554880224000,"modified":1555034963000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 6 regulatory subunit 3","accession":"Q5H9R7","gene":"PPP6R3","description":"Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0556510914072046,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":109.633444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.12594145958087,"pubTatorScore":1.851654263119143,"self":"https://pharos.nih.gov/idg/api/v1/targets(3730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(3730)/properties"},"_links":{"count":1251,"href":"https://pharos.nih.gov/idg/api/v1/targets(3730)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(3730)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3730)/publications"},"_namespace":null},{"id":3731,"version":2,"created":1554880228000,"modified":1554880230000,"deprecated":false,"name":"MOB kinase activator 3C","accession":"Q70IA8","gene":"MOB3C","description":"May regulate the activity of kinases.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.46788217183638,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3731)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(3731)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3731)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3731)/publications"},"_namespace":null},{"id":3732,"version":2,"created":1554880231000,"modified":1554880233000,"deprecated":false,"name":"Disks large-associated protein 3","accession":"O95886","gene":"DLGAP3","description":"May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2627429337715521,"antibodyCount":94,"monoclonalCount":4,"pubmedCount":null,"jensenScore":19.120004,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.1647968858018,"pubTatorScore":1.1280041201486848,"self":"https://pharos.nih.gov/idg/api/v1/targets(3732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(3732)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(3732)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3732)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3732)/publications"},"_namespace":null},{"id":3733,"version":2,"created":1554880233000,"modified":1554880235000,"deprecated":false,"name":"Transmembrane emp24 domain-containing protein 1","accession":"Q13445","gene":"TMED1","description":"Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5740312622990379,"antibodyCount":106,"monoclonalCount":17,"pubmedCount":null,"jensenScore":3.740385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.14547534871709,"pubTatorScore":0.31875869313729016,"self":"https://pharos.nih.gov/idg/api/v1/targets(3733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(3733)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(3733)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3733)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3733)/publications"},"_namespace":null},{"id":3734,"version":3,"created":1554880236000,"modified":1555034965000,"deprecated":false,"name":"MOB kinase activator 2","accession":"Q70IA6","gene":"MOB2","description":"Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4306930541574014,"antibodyCount":122,"monoclonalCount":11,"pubmedCount":null,"jensenScore":27.667577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.334707575857045,"pubTatorScore":1.0220419122896724,"self":"https://pharos.nih.gov/idg/api/v1/targets(3734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(3734)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(3734)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3734)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3734)/publications"},"_namespace":null},{"id":3735,"version":2,"created":1554880239000,"modified":1554880241000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 15","accession":"Q13444","gene":"ADAM15","description":"Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8740817319268719,"antibodyCount":301,"monoclonalCount":98,"pubmedCount":null,"jensenScore":84.092536,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.39098978798782,"pubTatorScore":1.8961894701652107,"self":"https://pharos.nih.gov/idg/api/v1/targets(3735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3735)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(3735)/links"},"_synonyms":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(3735)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3735)/publications"},"_namespace":null},{"id":3736,"version":3,"created":1554880242000,"modified":1555034966000,"deprecated":false,"name":"H2.0-like homeobox protein","accession":"Q14774","gene":"HLX","description":"Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8254695011761246,"antibodyCount":189,"monoclonalCount":10,"pubmedCount":null,"jensenScore":73.221022,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":34.04320296557896,"pubTatorScore":1.7002738210968622,"self":"https://pharos.nih.gov/idg/api/v1/targets(3736)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(3736)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(3736)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3736)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3736)/publications"},"_namespace":null},{"id":3737,"version":2,"created":1554880246000,"modified":1554880253000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 9","accession":"Q13443","gene":"ADAM9","description":"Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.088069342767976,"antibodyCount":258,"monoclonalCount":66,"pubmedCount":null,"jensenScore":122.346625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.29123123314473,"pubTatorScore":2.033491033750244,"self":"https://pharos.nih.gov/idg/api/v1/targets(3737)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(3737)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(3737)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3737)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3737)/publications"},"_namespace":null},{"id":3738,"version":2,"created":1554880254000,"modified":1554880256000,"deprecated":false,"name":"Transmembrane protein 263","accession":"Q8WUH6","gene":"TMEM263","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.40576534695952005,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.381818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.475423871931433,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(3738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3738)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(3738)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3738)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3738)/publications"},"_namespace":null},{"id":3739,"version":2,"created":1554880257000,"modified":1554880258000,"deprecated":false,"name":"Zinc finger protein ZIC 4","accession":"Q8N9L1","gene":"ZIC4","description":"Binds to DNA.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3027880991359817,"antibodyCount":326,"monoclonalCount":168,"pubmedCount":null,"jensenScore":16.057674,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.55059749584197,"pubTatorScore":1.1188089564916943,"self":"https://pharos.nih.gov/idg/api/v1/targets(3739)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(3739)/properties"},"_links":{"count":660,"href":"https://pharos.nih.gov/idg/api/v1/targets(3739)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3739)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3739)/publications"},"_namespace":null},{"id":3740,"version":2,"created":1554880259000,"modified":1554880261000,"deprecated":false,"name":"Limbic system-associated membrane protein","accession":"Q13449","gene":"LSAMP","description":"Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7274422821720072,"antibodyCount":72,"monoclonalCount":7,"pubmedCount":null,"jensenScore":52.776223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.07542303444373,"pubTatorScore":1.546188630902209,"self":"https://pharos.nih.gov/idg/api/v1/targets(3740)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(3740)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(3740)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3740)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3740)/publications"},"_namespace":null},{"id":3741,"version":3,"created":1554880262000,"modified":1555034968000,"deprecated":false,"name":"tRNA (cytosine(34)-C(5))-methyltransferase","accession":"Q08J23","gene":"NSUN2","description":"RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8961367813561136,"antibodyCount":108,"monoclonalCount":1,"pubmedCount":null,"jensenScore":80.134503,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":45.59132620067104,"pubTatorScore":1.5173215875520714,"self":"https://pharos.nih.gov/idg/api/v1/targets(3741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(3741)/properties"},"_links":{"count":1198,"href":"https://pharos.nih.gov/idg/api/v1/targets(3741)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3741)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3741)/publications"},"_namespace":null},{"id":3742,"version":2,"created":1554880266000,"modified":1554880269000,"deprecated":false,"name":"Zinc finger and BTB domain-containing protein 40","accession":"Q9NUA8","gene":"ZBTB40","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.2710849447059734,"antibodyCount":127,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.810785,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.32441121426639,"pubTatorScore":0.39453958153895047,"self":"https://pharos.nih.gov/idg/api/v1/targets(3742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(3742)/properties"},"_links":{"count":822,"href":"https://pharos.nih.gov/idg/api/v1/targets(3742)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3742)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3742)/publications"},"_namespace":null},{"id":3743,"version":2,"created":1554880270000,"modified":1554880270000,"deprecated":false,"name":"Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase","accession":"A6NGE7","gene":"URAD","description":"Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.8750612742490622,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.500122023230473,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(3743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3743)/properties"},"_links":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3743)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3743)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3743)/publications"},"_namespace":null},{"id":3744,"version":2,"created":1554880270000,"modified":1554880272000,"deprecated":false,"name":"Acyl-coenzyme A thioesterase 4","accession":"Q8N9L9","gene":"ACOT4","description":"Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5378735809508879,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.873443,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.27096074158126,"pubTatorScore":0.15248220442000499,"self":"https://pharos.nih.gov/idg/api/v1/targets(3744)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(3744)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(3744)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3744)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3744)/publications"},"_namespace":null},{"id":3745,"version":3,"created":1554880273000,"modified":1555034969000,"deprecated":false,"name":"Thioredoxin domain-containing protein 12","accession":"O95881","gene":"TXNDC12","description":"Possesses significant protein thiol-disulfide oxidase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4876713480582089,"antibodyCount":103,"monoclonalCount":5,"pubmedCount":null,"jensenScore":32.379601,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.4896322015601,"pubTatorScore":1.7084518435765277,"self":"https://pharos.nih.gov/idg/api/v1/targets(3745)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(3745)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(3745)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3745)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3745)/publications"},"_namespace":null},{"id":3746,"version":2,"created":1554880276000,"modified":1554880276000,"deprecated":false,"name":"Putative uncharacterized protein FLJ36925","accession":"Q8N9L7","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3746)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3746)/links"},"_synonyms":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3746)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3746)/publications"},"_namespace":null},{"id":3747,"version":3,"created":1554880276000,"modified":1555034971000,"deprecated":false,"name":"Protein Churchill","accession":"Q8WUH1","gene":"CHURC1","description":"Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.2845189588718138,"antibodyCount":45,"monoclonalCount":21,"pubmedCount":null,"jensenScore":183.583935,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":29.413418043597755,"pubTatorScore":1.867969588414423,"self":"https://pharos.nih.gov/idg/api/v1/targets(3747)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3747)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(3747)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3747)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3747)/publications"},"_namespace":null},{"id":3748,"version":2,"created":1554880278000,"modified":1554880278000,"deprecated":false,"name":"Putative uncharacterized protein PRO1854","accession":"Q9UHT4","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3748)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3748)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3748)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3748)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3748)/publications"},"_namespace":null},{"id":3749,"version":2,"created":1554880278000,"modified":1554880278000,"deprecated":false,"name":"Putative uncharacterized protein PRO0628","accession":"Q9UI54","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3749)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3749)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3749)/links"},"_synonyms":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3749)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3749)/publications"},"_namespace":null},{"id":3750,"version":2,"created":1554880279000,"modified":1554880281000,"deprecated":false,"name":"Transforming growth factor-beta receptor-associated protein 1","accession":"Q8WUH2","gene":"TGFBRAP1","description":"Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (PubMed:25266290).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0312641602289592,"antibodyCount":179,"monoclonalCount":47,"pubmedCount":null,"jensenScore":9.095251,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.50866120933932,"pubTatorScore":0.4097722186845579,"self":"https://pharos.nih.gov/idg/api/v1/targets(3750)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(3750)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(3750)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3750)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3750)/publications"},"_namespace":null},{"id":3751,"version":2,"created":1554880282000,"modified":1554880282000,"deprecated":false,"name":"Cutaneous T-cell lymphoma-associated antigen 1","accession":"Q9HC47","gene":"CTAGE1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":70,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(3751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3751)/properties"},"_links":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(3751)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3751)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3751)/publications"},"_namespace":null},{"id":3752,"version":2,"created":1554880282000,"modified":1554880285000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 17","accession":"Q5H9S7","gene":"DCAF17","description":"May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3033433790242857,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.528903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.779963002534096,"pubTatorScore":1.2793880757971907,"self":"https://pharos.nih.gov/idg/api/v1/targets(3752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3752)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(3752)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3752)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3752)/publications"},"_namespace":null},{"id":3753,"version":3,"created":1554880285000,"modified":1555034972000,"deprecated":false,"name":"Vasculin-like protein 1","accession":"Q9HC44","gene":"GPBP1L1","description":"Possible transcription factor.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6232492869235446,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":30.579616900765053,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(3753)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(3753)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3753)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3753)/publications"},"_namespace":null},{"id":3754,"version":2,"created":1554880288000,"modified":1554880291000,"deprecated":false,"name":"Acetyl-coenzyme A synthetase 2-like, mitochondrial","accession":"Q9NUB1","gene":"ACSS1","description":"Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4880044051046382,"antibodyCount":73,"monoclonalCount":5,"pubmedCount":null,"jensenScore":26.795067,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.734147260678505,"pubTatorScore":0.7549317944288396,"self":"https://pharos.nih.gov/idg/api/v1/targets(3754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3754)/properties"},"_links":{"count":1074,"href":"https://pharos.nih.gov/idg/api/v1/targets(3754)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(3754)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3754)/publications"},"_namespace":null},{"id":3755,"version":2,"created":1554880292000,"modified":1554880303000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase FKBP5","accession":"Q13451","gene":"FKBP5","description":"Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.521136381273004,"antibodyCount":299,"monoclonalCount":153,"pubmedCount":null,"jensenScore":348.086541,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.69465328509553,"pubTatorScore":2.3433648292900093,"self":"https://pharos.nih.gov/idg/api/v1/targets(3755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":645,"href":"https://pharos.nih.gov/idg/api/v1/targets(3755)/properties"},"_links":{"count":1403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3755)/links"},"_synonyms":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(3755)/synonyms"},"_publications":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3755)/publications"},"_namespace":null},{"id":3756,"version":2,"created":1554880304000,"modified":1554880307000,"deprecated":false,"name":"BUD13 homolog","accession":"Q9BRD0","gene":"BUD13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1468459094280106,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.841549,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.7157298699813,"pubTatorScore":0.7704428460519839,"self":"https://pharos.nih.gov/idg/api/v1/targets(3756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(3756)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(3756)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3756)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3756)/publications"},"_namespace":null},{"id":3757,"version":2,"created":1554880307000,"modified":1554880310000,"deprecated":false,"name":"Chromobox protein homolog 2","accession":"Q14781","gene":"CBX2","description":"Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.3736867383746547,"antibodyCount":223,"monoclonalCount":40,"pubmedCount":null,"jensenScore":24.337594,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.51364760548889,"pubTatorScore":1.5877641207569988,"self":"https://pharos.nih.gov/idg/api/v1/targets(3757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(3757)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(3757)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3757)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(3757)/publications"},"_namespace":null},{"id":3758,"version":3,"created":1554880311000,"modified":1555034974000,"deprecated":false,"name":"Noelin-2","accession":"O95897","gene":"OLFM2","description":"Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0813600334269047,"antibodyCount":40,"monoclonalCount":1,"pubmedCount":null,"jensenScore":12.489603,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":25.92870794062335,"pubTatorScore":0.895570103737756,"self":"https://pharos.nih.gov/idg/api/v1/targets(3758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(3758)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(3758)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3758)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3758)/publications"},"_namespace":null},{"id":3759,"version":3,"created":1554880314000,"modified":1555034975000,"deprecated":false,"name":"Uncharacterized protein C20orf141","accession":"Q9NUB4","gene":"C20orf141","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":60,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3759)/properties"},"_links":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(3759)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3759)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3759)/publications"},"_namespace":null},{"id":3760,"version":3,"created":1554880314000,"modified":1555034976000,"deprecated":false,"name":"Tumor suppressor candidate 3","accession":"Q13454","gene":"TUSC3","description":"Magnesium transporter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9429176575442704,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":81.527185,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.47790348394884,"pubTatorScore":1.8184095982824182,"self":"https://pharos.nih.gov/idg/api/v1/targets(3760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3760)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(3760)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(3760)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3760)/publications"},"_namespace":null},{"id":3761,"version":3,"created":1554880318000,"modified":1555034977000,"deprecated":false,"name":"Solute carrier family 22 member 17","accession":"Q8WUG5","gene":"SLC22A17","description":"Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.300906152536933,"antibodyCount":147,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.53789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.137248580754417,"pubTatorScore":1.129528741629129,"self":"https://pharos.nih.gov/idg/api/v1/targets(3761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3761)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(3761)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3761)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3761)/publications"},"_namespace":null},{"id":3762,"version":2,"created":1554880321000,"modified":1554880324000,"deprecated":false,"name":"Unconventional myosin-IXb","accession":"Q13459","gene":"MYO9B","description":"Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.685912315196416,"antibodyCount":79,"monoclonalCount":5,"pubmedCount":null,"jensenScore":55.733261,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.38559433498085,"pubTatorScore":1.8016731359982332,"self":"https://pharos.nih.gov/idg/api/v1/targets(3762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":495,"href":"https://pharos.nih.gov/idg/api/v1/targets(3762)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3762)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3762)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3762)/publications"},"_namespace":null},{"id":3763,"version":2,"created":1554880325000,"modified":1554880328000,"deprecated":false,"name":"Golgin subfamily B member 1","accession":"Q14789","gene":"GOLGB1","description":"May participate in forming intercisternal cross-bridges of the Golgi complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.753851162126595,"antibodyCount":88,"monoclonalCount":28,"pubmedCount":null,"jensenScore":540.484177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.971891216821945,"pubTatorScore":2.231619946510852,"self":"https://pharos.nih.gov/idg/api/v1/targets(3763)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(3763)/properties"},"_links":{"count":1240,"href":"https://pharos.nih.gov/idg/api/v1/targets(3763)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3763)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(3763)/publications"},"_namespace":null},{"id":3764,"version":2,"created":1554880329000,"modified":1554880329000,"deprecated":false,"name":"Uncharacterized protein KIAA1456 isoform","accession":"Q8N9K7","gene":"TRMT9B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3764)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3764)/properties"},"_links":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3764)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3764)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3764)/publications"},"_namespace":null},{"id":3765,"version":2,"created":1554880330000,"modified":1554880332000,"deprecated":false,"name":"Zinc finger protein 565","accession":"Q8N9K5","gene":"ZNF565","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":71,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.227632864272866,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3765)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3765)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(3765)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(3765)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3765)/publications"},"_namespace":null},{"id":3766,"version":2,"created":1554880332000,"modified":1554880333000,"deprecated":false,"name":"Putative uncharacterized protein C9orf92","accession":"A6NGG3","gene":"C9orf92","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3766)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3766)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3766)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(3766)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3766)/publications"},"_namespace":null},{"id":3767,"version":2,"created":1554880333000,"modified":1554880333000,"deprecated":false,"name":"Putative uncharacterized protein PRO1716","accession":"Q9UHU1","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3767)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3767)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(3767)/links"},"_synonyms":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3767)/synonyms"},"_publications":null,"_namespace":null},{"id":3768,"version":2,"created":1554880333000,"modified":1554880335000,"deprecated":false,"name":"Glyoxalase domain-containing protein 4","accession":"Q9HC38","gene":"GLOD4","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7283245022228497,"antibodyCount":69,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.42370249535082,"pubTatorScore":0.8260748027008264,"self":"https://pharos.nih.gov/idg/api/v1/targets(3768)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3768)/properties"},"_links":{"count":1048,"href":"https://pharos.nih.gov/idg/api/v1/targets(3768)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3768)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3768)/publications"},"_namespace":null},{"id":3769,"version":4,"created":1554880336000,"modified":1555034979000,"deprecated":false,"name":"Glutamate receptor ionotropic, kainate 1","accession":"P39086","gene":"GRIK1","description":"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.44486926091999,"antibodyCount":219,"monoclonalCount":9,"pubmedCount":null,"jensenScore":279.668861,"patentCount":72571,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.53081771284408,"pubTatorScore":2.1586460480900644,"self":"https://pharos.nih.gov/idg/api/v1/targets(3769)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(3769)/properties"},"_links":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(3769)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(3769)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(3769)/publications"},"_namespace":null},{"id":3770,"version":2,"created":1554880396000,"modified":1554880398000,"deprecated":false,"name":"Uncharacterized protein C2orf71","accession":"A6NGG8","gene":"C2orf71","description":"May play an important role in the development of normal vision.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9120026240626988,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.96153,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.0889934078441585,"self":"https://pharos.nih.gov/idg/api/v1/targets(3770)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(3770)/properties"},"_links":{"count":702,"href":"https://pharos.nih.gov/idg/api/v1/targets(3770)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3770)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3770)/publications"},"_namespace":null},{"id":3771,"version":3,"created":1554880398000,"modified":1555034981000,"deprecated":false,"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4","accession":"Q9BRC7","gene":"PLCD4","description":"Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0992063796696259,"antibodyCount":47,"monoclonalCount":9,"pubmedCount":null,"jensenScore":11.399441,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":30.55374620893415,"pubTatorScore":1.0969513558748443,"self":"https://pharos.nih.gov/idg/api/v1/targets(3771)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(3771)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(3771)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(3771)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3771)/publications"},"_namespace":null},{"id":3772,"version":2,"created":1554880401000,"modified":1554880404000,"deprecated":false,"name":"Echinoderm microtubule-associated protein-like 4","accession":"Q9HC35","gene":"EML4","description":"May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.421520098753874,"antibodyCount":83,"monoclonalCount":17,"pubmedCount":null,"jensenScore":197.480257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.29670494444603,"pubTatorScore":2.2965358104581726,"self":"https://pharos.nih.gov/idg/api/v1/targets(3772)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(3772)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3772)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3772)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3772)/publications"},"_namespace":null},{"id":3773,"version":4,"created":1554880406000,"modified":1555034983000,"deprecated":false,"name":"Caspase-8","accession":"Q14790","gene":"CASP8","description":"Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.5422391778366005,"antibodyCount":1045,"monoclonalCount":297,"pubmedCount":null,"jensenScore":3121.413775,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":62.62878085983197,"pubTatorScore":3.320289007772794,"self":"https://pharos.nih.gov/idg/api/v1/targets(3773)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3773)/properties"},"_links":{"count":1960,"href":"https://pharos.nih.gov/idg/api/v1/targets(3773)/links"},"_synonyms":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(3773)/synonyms"},"_publications":{"count":704,"href":"https://pharos.nih.gov/idg/api/v1/targets(3773)/publications"},"_namespace":null},{"id":3774,"version":3,"created":1554880438000,"modified":1555034987000,"deprecated":false,"name":"rRNA methyltransferase 3, mitochondrial","accession":"Q9HC36","gene":"MRM3","description":"S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9030899869919435,"antibodyCount":51,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.165385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":0.0,"pubTatorScore":0.8314431375003237,"self":"https://pharos.nih.gov/idg/api/v1/targets(3774)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(3774)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(3774)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3774)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3774)/publications"},"_namespace":null},{"id":3775,"version":3,"created":1554880443000,"modified":1555034989000,"deprecated":false,"name":"SERTA domain-containing protein 4","accession":"Q9NUC0","gene":"SERTAD4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.19188552747975451,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.37037,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":28.792476990366872,"pubTatorScore":-0.38021089427615945,"self":"https://pharos.nih.gov/idg/api/v1/targets(3775)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(3775)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(3775)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3775)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3775)/publications"},"_namespace":null},{"id":3776,"version":3,"created":1554880445000,"modified":1554880497000,"deprecated":false,"name":"Rho-associated protein kinase 1","accession":"Q13464","gene":"ROCK1","description":"Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.6462222116953784,"antibodyCount":461,"monoclonalCount":153,"pubmedCount":null,"jensenScore":378.194273,"patentCount":15449,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.70939010319713,"pubTatorScore":2.470502005146432,"self":"https://pharos.nih.gov/idg/api/v1/targets(3776)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/properties"},"_links":{"count":1593,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/links"},"_synonyms":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/synonyms"},"_publications":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(3776)/publications"},"_namespace":null},{"id":3777,"version":2,"created":1554880499000,"modified":1554880501000,"deprecated":false,"name":"Putative sodium-coupled neutral amino acid transporter 10","accession":"Q9HBR0","gene":"SLC38A10","description":"Putative sodium-dependent amino acid/proton antiporter.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.2771178356217819,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.708333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.65230000201429,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3777)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3777)/publications"},"_namespace":null},{"id":3778,"version":2,"created":1554880502000,"modified":1554880505000,"deprecated":false,"name":"Forkhead box protein E3","accession":"Q13461","gene":"FOXE3","description":"Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5370102673467352,"antibodyCount":150,"monoclonalCount":0,"pubmedCount":null,"jensenScore":31.543689,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.844476144550917,"pubTatorScore":1.4768083196872606,"self":"https://pharos.nih.gov/idg/api/v1/targets(3778)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/properties"},"_links":{"count":628,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3778)/publications"},"_namespace":null},{"id":3779,"version":2,"created":1554880505000,"modified":1554880508000,"deprecated":false,"name":"Protein FAM172A","accession":"Q8WUF8","gene":"FAM172A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8822398512760321,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.60212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.90106701868642,"pubTatorScore":0.8091854541722678,"self":"https://pharos.nih.gov/idg/api/v1/targets(3779)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3779)/publications"},"_namespace":null},{"id":3780,"version":3,"created":1554880508000,"modified":1555034990000,"deprecated":false,"name":"Frizzled-5","accession":"Q13467","gene":"FZD5","description":"Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.549241895088374,"antibodyCount":307,"monoclonalCount":41,"pubmedCount":null,"jensenScore":30.549361,"patentCount":7363,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.18168485932191,"pubTatorScore":1.3952682618773533,"self":"https://pharos.nih.gov/idg/api/v1/targets(3780)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3780)/publications"},"_namespace":null},{"id":3781,"version":3,"created":1554880512000,"modified":1555034992000,"deprecated":false,"name":"Branched-chain-amino-acid aminotransferase, cytosolic","accession":"P54687","gene":"BCAT1","description":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.8865864759455342,"antibodyCount":216,"monoclonalCount":20,"pubmedCount":null,"jensenScore":78.087049,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":44.84462864291546,"pubTatorScore":1.5835504440958579,"self":"https://pharos.nih.gov/idg/api/v1/targets(3781)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/properties"},"_links":{"count":1079,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(3781)/publications"},"_namespace":null},{"id":3782,"version":2,"created":1554880518000,"modified":1554880521000,"deprecated":false,"name":"RelA-associated inhibitor","accession":"Q8WUF5","gene":"PPP1R13L","description":"Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7613062018504857,"antibodyCount":185,"monoclonalCount":11,"pubmedCount":null,"jensenScore":64.541084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.40324271872569,"pubTatorScore":1.8285692844911037,"self":"https://pharos.nih.gov/idg/api/v1/targets(3782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3782)/publications"},"_namespace":null},{"id":3783,"version":2,"created":1554880522000,"modified":1554880524000,"deprecated":false,"name":"MDS1 and EVI1 complex locus protein MDS1","accession":"Q13465","gene":"MECOM","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8405952464351278,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":124.51994,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.01900411149362,"pubTatorScore":2.365201894660987,"self":"https://pharos.nih.gov/idg/api/v1/targets(3783)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/properties"},"_links":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3783)/publications"},"_namespace":null},{"id":3784,"version":3,"created":1554880524000,"modified":1555034994000,"deprecated":false,"name":"Death-associated protein kinase 1","accession":"P53355","gene":"DAPK1","description":"Isoform 2 cannot induce apoptosis but can induce membrane blebbing.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.341526874088907,"antibodyCount":276,"monoclonalCount":30,"pubmedCount":null,"jensenScore":226.06942,"patentCount":11312,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":52.38339282743986,"pubTatorScore":2.4879233100889064,"self":"https://pharos.nih.gov/idg/api/v1/targets(3784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":613,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/properties"},"_links":{"count":1194,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/links"},"_synonyms":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/synonyms"},"_publications":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3784)/publications"},"_namespace":null},{"id":3785,"version":2,"created":1554880530000,"modified":1554880531000,"deprecated":false,"name":"Potassium channel subfamily U member 1","accession":"A8MYU2","gene":"KCNU1","description":"Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.6577159207132586,"antibodyCount":45,"monoclonalCount":42,"pubmedCount":null,"jensenScore":43.300305,"patentCount":2762,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.5918035943183,"pubTatorScore":1.1487054174494093,"self":"https://pharos.nih.gov/idg/api/v1/targets(3785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/properties"},"_links":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3785)/publications"},"_namespace":null},{"id":3786,"version":4,"created":1554880532000,"modified":1555034997000,"deprecated":false,"name":"Serine/threonine-protein kinase PLK1","accession":"P53350","gene":"PLK1","description":"Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.0961018918649352,"antibodyCount":856,"monoclonalCount":337,"pubmedCount":null,"jensenScore":1271.145831,"patentCount":74781,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":56.48273228360455,"pubTatorScore":2.9693791295019953,"self":"https://pharos.nih.gov/idg/api/v1/targets(3786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/properties"},"_links":{"count":1706,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/links"},"_synonyms":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/synonyms"},"_publications":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(3786)/publications"},"_namespace":null},{"id":3787,"version":2,"created":1554880603000,"modified":1554880607000,"deprecated":false,"name":"Nuclear factor of activated T-cells, cytoplasmic 2","accession":"Q13469","gene":"NFATC2","description":"Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.432071850227694,"antibodyCount":365,"monoclonalCount":51,"pubmedCount":null,"jensenScore":259.361842,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.04306580732003,"pubTatorScore":2.2783543099688837,"self":"https://pharos.nih.gov/idg/api/v1/targets(3787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":602,"href":"https://pharos.nih.gov/idg/api/v1/targets(3787)/properties"},"_links":{"count":1114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3787)/links"},"_synonyms":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(3787)/synonyms"},"_publications":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(3787)/publications"},"_namespace":null},{"id":3788,"version":3,"created":1554880608000,"modified":1555035002000,"deprecated":false,"name":"Probable E3 ubiquitin-protein ligase DTX3","accession":"Q8N9I9","gene":"DTX3","description":"Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1254971928741793,"antibodyCount":123,"monoclonalCount":18,"pubmedCount":null,"jensenScore":13.400511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":28.664018624556757,"pubTatorScore":0.5807349160095776,"self":"https://pharos.nih.gov/idg/api/v1/targets(3788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3788)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(3788)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3788)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3788)/publications"},"_namespace":null},{"id":3789,"version":2,"created":1554880611000,"modified":1554880613000,"deprecated":false,"name":"Phosphatidylinositol transfer protein alpha isoform","accession":"Q00169","gene":"PITPNA","description":"Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5399866738230565,"antibodyCount":126,"monoclonalCount":14,"pubmedCount":null,"jensenScore":36.291963,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.44053526244066,"pubTatorScore":1.3401370850717973,"self":"https://pharos.nih.gov/idg/api/v1/targets(3789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(3789)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(3789)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3789)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3789)/publications"},"_namespace":null},{"id":3790,"version":3,"created":1554880614000,"modified":1555035004000,"deprecated":false,"name":"Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q","accession":"Q9BRB3","gene":"PIGQ","description":"Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.3884584116333747,"antibodyCount":50,"monoclonalCount":10,"pubmedCount":null,"jensenScore":23.871097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.47551672155372,"pubTatorScore":1.0569048132404637,"self":"https://pharos.nih.gov/idg/api/v1/targets(3790)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(3790)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(3790)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3790)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3790)/publications"},"_namespace":null},{"id":3791,"version":2,"created":1554880617000,"modified":1554880619000,"deprecated":false,"name":"SERTA domain-containing protein 1","accession":"Q9UHV2","gene":"SERTAD1","description":"Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2328372298040116,"antibodyCount":135,"monoclonalCount":9,"pubmedCount":null,"jensenScore":20.886987,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.81129812966782,"pubTatorScore":1.23855470795682,"self":"https://pharos.nih.gov/idg/api/v1/targets(3791)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3791)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(3791)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(3791)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3791)/publications"},"_namespace":null},{"id":3792,"version":2,"created":1554880620000,"modified":1554880620000,"deprecated":false,"name":"Putative golgin subfamily A member 2B","accession":"Q9HBQ8","gene":"GOLGA2P5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.99906609582124,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3792)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3792)/properties"},"_links":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3792)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3792)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3792)/publications"},"_namespace":null},{"id":3793,"version":2,"created":1554880620000,"modified":1554880620000,"deprecated":false,"name":"Putative uncharacterized protein PRO0255","accession":"Q9UI72","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3793)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3793)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3793)/links"},"_synonyms":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3793)/synonyms"},"_publications":null,"_namespace":null},{"id":3794,"version":2,"created":1554880620000,"modified":1554880621000,"deprecated":false,"name":"Coiled-coil domain-containing protein 160","accession":"A6NGH7","gene":"CCDC160","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.43836377621589,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3794)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(3794)/properties"},"_links":{"count":692,"href":"https://pharos.nih.gov/idg/api/v1/targets(3794)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(3794)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3794)/publications"},"_namespace":null},{"id":3795,"version":2,"created":1554880622000,"modified":1554880623000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 61","accession":"A6NGH8","gene":"ANKRD61","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.86611803885795,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3795)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(3795)/properties"},"_links":{"count":733,"href":"https://pharos.nih.gov/idg/api/v1/targets(3795)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3795)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3795)/publications"},"_namespace":null},{"id":3796,"version":2,"created":1554880624000,"modified":1554880636000,"deprecated":false,"name":"Nucleotide-binding oligomerization domain-containing protein 2","accession":"Q9HC29","gene":"NOD2","description":"Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.1362133469359406,"antibodyCount":370,"monoclonalCount":87,"pubmedCount":null,"jensenScore":1445.513542,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.90579870249842,"pubTatorScore":3.191949909066676,"self":"https://pharos.nih.gov/idg/api/v1/targets(3796)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1229,"href":"https://pharos.nih.gov/idg/api/v1/targets(3796)/properties"},"_links":{"count":1497,"href":"https://pharos.nih.gov/idg/api/v1/targets(3796)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3796)/synonyms"},"_publications":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(3796)/publications"},"_namespace":null},{"id":3797,"version":3,"created":1554880639000,"modified":1555035006000,"deprecated":false,"name":"MOB kinase activator 1B","accession":"Q7L9L4","gene":"MOB1B","description":"Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7666151288242992,"antibodyCount":235,"monoclonalCount":62,"pubmedCount":null,"jensenScore":5.015262,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":31.939783677212777,"pubTatorScore":0.464058765304295,"self":"https://pharos.nih.gov/idg/api/v1/targets(3797)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(3797)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(3797)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3797)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3797)/publications"},"_namespace":null},{"id":3798,"version":2,"created":1554880642000,"modified":1554880644000,"deprecated":false,"name":"Protein lifeguard 4","accession":"Q9HC24","gene":"TMBIM4","description":"Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.246714232006552,"antibodyCount":89,"monoclonalCount":2,"pubmedCount":null,"jensenScore":174.55171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.789830923992945,"pubTatorScore":1.6436171541121443,"self":"https://pharos.nih.gov/idg/api/v1/targets(3798)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(3798)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(3798)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3798)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3798)/publications"},"_namespace":null},{"id":3799,"version":2,"created":1554880645000,"modified":1554880647000,"deprecated":false,"name":"Rap guanine nucleotide exchange factor-like 1","accession":"Q9UHV5","gene":"RAPGEFL1","description":"Probable guanine nucleotide exchange factor (GEF).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2521814275057435,"antibodyCount":60,"monoclonalCount":27,"pubmedCount":null,"jensenScore":0.385714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.188636303473555,"pubTatorScore":-0.2730015434978737,"self":"https://pharos.nih.gov/idg/api/v1/targets(3799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3799)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(3799)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3799)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3799)/publications"},"_namespace":null},{"id":3800,"version":2,"created":1554880647000,"modified":1554880648000,"deprecated":false,"name":"Doublecortin domain-containing protein 2C","accession":"A8MYV0","gene":"DCDC2C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.15490196042003768,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.533333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.288757313192254,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3800)/properties"},"_links":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(3800)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(3800)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3800)/publications"},"_namespace":null},{"id":3801,"version":2,"created":1554880649000,"modified":1554880653000,"deprecated":false,"name":"Non-receptor tyrosine-protein kinase TNK1","accession":"Q13470","gene":"TNK1","description":"Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.7904689275817298,"antibodyCount":293,"monoclonalCount":72,"pubmedCount":null,"jensenScore":7.713649,"patentCount":2749,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.8053554306591,"pubTatorScore":0.9128744963323495,"self":"https://pharos.nih.gov/idg/api/v1/targets(3801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(3801)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(3801)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3801)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3801)/publications"},"_namespace":null},{"id":3802,"version":3,"created":1554880654000,"modified":1555035010000,"deprecated":false,"name":"Prokineticin-2","accession":"Q9HC23","gene":"PROK2","description":"May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.232394482233916,"antibodyCount":138,"monoclonalCount":0,"pubmedCount":null,"jensenScore":181.488384,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":31.377197729432254,"pubTatorScore":2.1672528357511425,"self":"https://pharos.nih.gov/idg/api/v1/targets(3802)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(3802)/properties"},"_links":{"count":757,"href":"https://pharos.nih.gov/idg/api/v1/targets(3802)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3802)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3802)/publications"},"_namespace":null},{"id":3803,"version":2,"created":1554880657000,"modified":1554880659000,"deprecated":false,"name":"Dystrophin-related protein 2","accession":"Q13474","gene":"DRP2","description":"Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7118072229610684,"antibodyCount":48,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.431418,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.0173923580818,"pubTatorScore":1.2730012489013647,"self":"https://pharos.nih.gov/idg/api/v1/targets(3803)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3803)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(3803)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3803)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3803)/publications"},"_namespace":null},{"id":3804,"version":3,"created":1554880660000,"modified":1555035012000,"deprecated":false,"name":"Prefoldin subunit 2","accession":"Q9UHV9","gene":"PFDN2","description":"Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8306293844853242,"antibodyCount":115,"monoclonalCount":11,"pubmedCount":null,"jensenScore":6.310281,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":36.358533026904134,"pubTatorScore":0.6293609676316648,"self":"https://pharos.nih.gov/idg/api/v1/targets(3804)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(3804)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(3804)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3804)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3804)/publications"},"_namespace":null},{"id":3805,"version":3,"created":1554880663000,"modified":1555035013000,"deprecated":false,"name":"Galactoside-binding soluble lectin 13","accession":"Q9UHV8","gene":"LGALS13","description":"Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9614851463683396,"antibodyCount":137,"monoclonalCount":98,"pubmedCount":null,"jensenScore":90.305249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":15.99104016922197,"pubTatorScore":1.8929355953622273,"self":"https://pharos.nih.gov/idg/api/v1/targets(3805)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3805)/properties"},"_links":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(3805)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3805)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(3805)/publications"},"_namespace":null},{"id":3806,"version":2,"created":1554880664000,"modified":1554880667000,"deprecated":false,"name":"Mediator of RNA polymerase II transcription subunit 13","accession":"Q9UHV7","gene":"MED13","description":"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5224964449215017,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.012318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.51861379782943,"pubTatorScore":1.0156058417756617,"self":"https://pharos.nih.gov/idg/api/v1/targets(3806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(3806)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(3806)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3806)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3806)/publications"},"_namespace":null},{"id":3807,"version":2,"created":1554880667000,"modified":1554880670000,"deprecated":false,"name":"Mitochondrial thiamine pyrophosphate carrier","accession":"Q9HC21","gene":"SLC25A19","description":"Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.3461162963457887,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":194.478535,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.42352371463679,"pubTatorScore":1.750272616180762,"self":"https://pharos.nih.gov/idg/api/v1/targets(3807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(3807)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(3807)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3807)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3807)/publications"},"_namespace":null},{"id":3808,"version":2,"created":1554880670000,"modified":1554880673000,"deprecated":false,"name":"DNA topoisomerase 3-alpha","accession":"Q13472","gene":"TOP3A","description":"Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.778966752011617,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":560.745375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.7704309849475,"pubTatorScore":1.6974645829278323,"self":"https://pharos.nih.gov/idg/api/v1/targets(3808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(3808)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(3808)/links"},"_synonyms":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(3808)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(3808)/publications"},"_namespace":null},{"id":3809,"version":3,"created":1554880674000,"modified":1555035014000,"deprecated":false,"name":"Adenomatous polyposis coli protein","accession":"P25054","gene":"APC","description":"Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9064634521334012,"antibodyCount":508,"monoclonalCount":100,"pubmedCount":null,"jensenScore":66.473117,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":64.74026498468305,"pubTatorScore":2.962227772382036,"self":"https://pharos.nih.gov/idg/api/v1/targets(3809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1208,"href":"https://pharos.nih.gov/idg/api/v1/targets(3809)/properties"},"_links":{"count":1750,"href":"https://pharos.nih.gov/idg/api/v1/targets(3809)/links"},"_synonyms":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3809)/synonyms"},"_publications":{"count":712,"href":"https://pharos.nih.gov/idg/api/v1/targets(3809)/publications"},"_namespace":null},{"id":3810,"version":3,"created":1554880685000,"modified":1555035018000,"deprecated":false,"name":"Paxillin","accession":"P49023","gene":"PXN","description":"Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.994373406133986,"antibodyCount":1251,"monoclonalCount":209,"pubmedCount":null,"jensenScore":902.94362,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":59.633008372625085,"pubTatorScore":2.43944728349794,"self":"https://pharos.nih.gov/idg/api/v1/targets(3810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":686,"href":"https://pharos.nih.gov/idg/api/v1/targets(3810)/properties"},"_links":{"count":1381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3810)/links"},"_synonyms":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(3810)/synonyms"},"_publications":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(3810)/publications"},"_namespace":null},{"id":3811,"version":3,"created":1554880693000,"modified":1555035022000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1","accession":"Q12824","gene":"SMARCB1","description":"Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7763535227874483,"antibodyCount":379,"monoclonalCount":126,"pubmedCount":null,"jensenScore":619.834247,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":52.20513450883569,"pubTatorScore":2.735554624951012,"self":"https://pharos.nih.gov/idg/api/v1/targets(3811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":717,"href":"https://pharos.nih.gov/idg/api/v1/targets(3811)/properties"},"_links":{"count":1456,"href":"https://pharos.nih.gov/idg/api/v1/targets(3811)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(3811)/synonyms"},"_publications":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(3811)/publications"},"_namespace":null},{"id":3812,"version":2,"created":1554880700000,"modified":1554880701000,"deprecated":false,"name":"Gasdermin-C","accession":"Q9BYG8","gene":"GSDMC","description":"The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6774367561872617,"antibodyCount":108,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.258922,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.045801903097846,"pubTatorScore":0.39959135344215413,"self":"https://pharos.nih.gov/idg/api/v1/targets(3812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3812)/properties"},"_links":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(3812)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3812)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3812)/publications"},"_namespace":null},{"id":3813,"version":3,"created":1554880702000,"modified":1555035024000,"deprecated":false,"name":"Ras-related protein Rab-40B","accession":"Q12829","gene":"RAB40B","description":"May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5079250381652712,"antibodyCount":108,"monoclonalCount":7,"pubmedCount":null,"jensenScore":2.445761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":31.519659784595994,"pubTatorScore":1.9051468942361813,"self":"https://pharos.nih.gov/idg/api/v1/targets(3813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(3813)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(3813)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(3813)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3813)/publications"},"_namespace":null},{"id":3814,"version":2,"created":1554880705000,"modified":1554880707000,"deprecated":false,"name":"Fibrous sheath-interacting protein 1","accession":"Q8NA03","gene":"FSIP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5159742086024062,"antibodyCount":113,"monoclonalCount":39,"pubmedCount":null,"jensenScore":36.951306,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.793921288907065,"pubTatorScore":1.0394140795145388,"self":"https://pharos.nih.gov/idg/api/v1/targets(3814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(3814)/properties"},"_links":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(3814)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(3814)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3814)/publications"},"_namespace":null},{"id":3815,"version":3,"created":1554880708000,"modified":1555035026000,"deprecated":false,"name":"MKI67 FHA domain-interacting nucleolar phosphoprotein","accession":"Q9BYG3","gene":"NIFK","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9175453218495842,"antibodyCount":289,"monoclonalCount":53,"pubmedCount":null,"jensenScore":83.759471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":55,"knowledgeAvailability":34.51918553812711,"pubTatorScore":1.412900314572227,"self":"https://pharos.nih.gov/idg/api/v1/targets(3815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(3815)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(3815)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3815)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3815)/publications"},"_namespace":null},{"id":3816,"version":2,"created":1554880711000,"modified":1554880714000,"deprecated":false,"name":"Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase","accession":"Q9BYG0","gene":"B3GNT5","description":"Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9606223710256052,"antibodyCount":95,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.355784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.70782405319739,"pubTatorScore":0.883030199379986,"self":"https://pharos.nih.gov/idg/api/v1/targets(3816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3816)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(3816)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3816)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3816)/publications"},"_namespace":null},{"id":3817,"version":2,"created":1554880715000,"modified":1554880717000,"deprecated":false,"name":"Protein maestro","accession":"Q9BYG7","gene":"MRO","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.1617719536207116,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":139.664593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.32583803610591,"pubTatorScore":1.153814864344529,"self":"https://pharos.nih.gov/idg/api/v1/targets(3817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3817)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(3817)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3817)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3817)/publications"},"_namespace":null},{"id":3818,"version":3,"created":1554880718000,"modified":1555035028000,"deprecated":false,"name":"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial","accession":"P13073","gene":"COX4I1","description":"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.343198676191038,"antibodyCount":504,"monoclonalCount":135,"pubmedCount":null,"jensenScore":203.337577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":37,"knowledgeAvailability":46.80100276438837,"pubTatorScore":1.8861310650594854,"self":"https://pharos.nih.gov/idg/api/v1/targets(3818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":453,"href":"https://pharos.nih.gov/idg/api/v1/targets(3818)/properties"},"_links":{"count":1226,"href":"https://pharos.nih.gov/idg/api/v1/targets(3818)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3818)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(3818)/publications"},"_namespace":null},{"id":3819,"version":3,"created":1554880722000,"modified":1555035030000,"deprecated":false,"name":"Partitioning defective 6 homolog beta","accession":"Q9BYG5","gene":"PARD6B","description":"Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.870316358077833,"antibodyCount":107,"monoclonalCount":8,"pubmedCount":null,"jensenScore":6.279899,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":37.416512927769745,"pubTatorScore":0.8863309656651985,"self":"https://pharos.nih.gov/idg/api/v1/targets(3819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(3819)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(3819)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3819)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3819)/publications"},"_namespace":null},{"id":3820,"version":3,"created":1554880725000,"modified":1555035031000,"deprecated":false,"name":"Partitioning defective 6 homolog gamma","accession":"Q9BYG4","gene":"PARD6G","description":"Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.390506909516548,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.621324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":25.874130731743147,"pubTatorScore":0.41774845734972443,"self":"https://pharos.nih.gov/idg/api/v1/targets(3820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(3820)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(3820)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3820)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3820)/publications"},"_namespace":null},{"id":3821,"version":2,"created":1554880728000,"modified":1554880728000,"deprecated":false,"name":"Putative uncharacterized protein FLJ26174","accession":"Q6ZPA2","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3821)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(3821)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3821)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3821)/publications"},"_namespace":null},{"id":3822,"version":2,"created":1554880728000,"modified":1554880735000,"deprecated":false,"name":"Hydroxycarboxylic acid receptor 3","accession":"P49019","gene":"HCAR3","description":"Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.211013323712002,"antibodyCount":147,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.560283,"patentCount":12403,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.51726015508541,"pubTatorScore":1.85896662995126,"self":"https://pharos.nih.gov/idg/api/v1/targets(3822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(3822)/properties"},"_links":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(3822)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3822)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3822)/publications"},"_namespace":null},{"id":3823,"version":2,"created":1554880735000,"modified":1554880738000,"deprecated":false,"name":"ELAV-like protein 4","accession":"P26378","gene":"ELAVL4","description":"May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.531624603844528,"antibodyCount":186,"monoclonalCount":105,"pubmedCount":null,"jensenScore":344.772744,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.532122625376022,"pubTatorScore":1.538836166413755,"self":"https://pharos.nih.gov/idg/api/v1/targets(3823)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(3823)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(3823)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(3823)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3823)/publications"},"_namespace":null},{"id":3824,"version":2,"created":1554880739000,"modified":1554880742000,"deprecated":false,"name":"Heterogeneous nuclear ribonucleoprotein U","accession":"Q00839","gene":"HNRNPU","description":"(Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3381296016017523,"antibodyCount":169,"monoclonalCount":62,"pubmedCount":null,"jensenScore":207.787231,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.279541269294484,"pubTatorScore":1.987227177737384,"self":"https://pharos.nih.gov/idg/api/v1/targets(3824)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":611,"href":"https://pharos.nih.gov/idg/api/v1/targets(3824)/properties"},"_links":{"count":1298,"href":"https://pharos.nih.gov/idg/api/v1/targets(3824)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(3824)/synonyms"},"_publications":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(3824)/publications"},"_namespace":null},{"id":3825,"version":2,"created":1554880744000,"modified":1554880748000,"deprecated":false,"name":"Nucleosome-remodeling factor subunit BPTF","accession":"Q12830","gene":"BPTF","description":"Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.7747199307306714,"antibodyCount":68,"monoclonalCount":33,"pubmedCount":null,"jensenScore":57.98608,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.732174802061074,"pubTatorScore":1.642146161689682,"self":"https://pharos.nih.gov/idg/api/v1/targets(3825)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3825)/publications"},"_namespace":null},{"id":3826,"version":3,"created":1554880749000,"modified":1555035032000,"deprecated":false,"name":"Collagen alpha-2(VIII) chain","accession":"P25067","gene":"COL8A2","description":"Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.957355194965767,"antibodyCount":93,"monoclonalCount":8,"pubmedCount":null,"jensenScore":89.481895,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":33.4551226647167,"pubTatorScore":1.9909006140260868,"self":"https://pharos.nih.gov/idg/api/v1/targets(3826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3826)/publications"},"_namespace":null},{"id":3827,"version":3,"created":1554880753000,"modified":1555035035000,"deprecated":false,"name":"Cell division cycle protein 20 homolog","accession":"Q12834","gene":"CDC20","description":"Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.604088533797081,"antibodyCount":393,"monoclonalCount":150,"pubmedCount":null,"jensenScore":401.481957,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":45.76102665314212,"pubTatorScore":2.3463574816997106,"self":"https://pharos.nih.gov/idg/api/v1/targets(3827)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/links"},"_synonyms":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/synonyms"},"_publications":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3827)/publications"},"_namespace":null},{"id":3828,"version":2,"created":1554880760000,"modified":1554880763000,"deprecated":false,"name":"Signal transducer CD24","accession":"P25063","gene":"CD24","description":"May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.04011718678892,"pubTatorScore":2.777508591834427,"self":"https://pharos.nih.gov/idg/api/v1/targets(3828)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/properties"},"_links":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/synonyms"},"_publications":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(3828)/publications"},"_namespace":null},{"id":3829,"version":2,"created":1554880764000,"modified":1554880766000,"deprecated":false,"name":"POU domain, class 4, transcription factor 2","accession":"Q12837","gene":"POU4F2","description":"Isoform 2: Acts either as a transcriptional activator or repressor (PubMed:23805044). Stimulates the promoter activity of the neuronal nicotinic acetylcholine receptor alpha CHRNA2. Negatively regulates the apoptosis regulator BAX promoter activity. Inhibits promoter activity of the neuronal intermediate filament protein alpha-internexin INA gene. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Inhibits the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors TP53 to potentiate transcriptional activation of BAX promoter activity, and hence increases neuronal cell apoptosis. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Acts also as a transcriptional coactivator via its interaction with the transcription factor ESR1 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9439672794490086,"antibodyCount":145,"monoclonalCount":0,"pubmedCount":null,"jensenScore":90.165125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.6181788215852,"pubTatorScore":1.656272191734912,"self":"https://pharos.nih.gov/idg/api/v1/targets(3829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/properties"},"_links":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3829)/publications"},"_namespace":null},{"id":3830,"version":2,"created":1554880766000,"modified":1554880767000,"deprecated":false,"name":"Zona pellucida sperm-binding protein 4","accession":"Q12836","gene":"ZP4","description":"The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.122174437699093,"antibodyCount":123,"monoclonalCount":0,"pubmedCount":null,"jensenScore":132.11768,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.360705020261705,"pubTatorScore":1.6839099758537412,"self":"https://pharos.nih.gov/idg/api/v1/targets(3830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/properties"},"_links":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3830)/publications"},"_namespace":null},{"id":3831,"version":2,"created":1554880767000,"modified":1554880790000,"deprecated":false,"name":"Angiotensin-converting enzyme 2","accession":"Q9BYF1","gene":"ACE2","description":"(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.0018845781692507,"antibodyCount":720,"monoclonalCount":112,"pubmedCount":null,"jensenScore":1129.290761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.06611125884824,"pubTatorScore":2.6826468524812337,"self":"https://pharos.nih.gov/idg/api/v1/targets(3831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/synonyms"},"_publications":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3831)/publications"},"_namespace":null},{"id":3832,"version":2,"created":1554880791000,"modified":1554880792000,"deprecated":false,"name":"Stress-responsive DNAJB4-interacting membrane protein 1","accession":"Q6ZPB5","gene":"SDIM1","description":"Promotes neuronal cells survival to stress conditions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.6020599913279624,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.978454841663302,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(3832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/links"},"_synonyms":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3832)/publications"},"_namespace":null},{"id":3833,"version":3,"created":1554880792000,"modified":1555035037000,"deprecated":false,"name":"MARCKS-related protein","accession":"P49006","gene":"MARCKSL1","description":"Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6416185165785717,"antibodyCount":171,"monoclonalCount":36,"pubmedCount":null,"jensenScore":43.579405,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":39.41191294616781,"pubTatorScore":1.8812972697557746,"self":"https://pharos.nih.gov/idg/api/v1/targets(3833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3833)/publications"},"_namespace":null},{"id":3834,"version":3,"created":1554880796000,"modified":1555035038000,"deprecated":false,"name":"DNA polymerase delta subunit 2","accession":"P49005","gene":"POLD2","description":"As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9522242496304052,"antibodyCount":115,"monoclonalCount":15,"pubmedCount":null,"jensenScore":8.518196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":40.8416603934872,"pubTatorScore":0.8646086676923714,"self":"https://pharos.nih.gov/idg/api/v1/targets(3834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/properties"},"_links":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3834)/publications"},"_namespace":null},{"id":3835,"version":2,"created":1554880800000,"modified":1554880803000,"deprecated":false,"name":"Kinesin heavy chain isoform 5A","accession":"Q12840","gene":"KIF5A","description":"Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6913052109592885,"antibodyCount":170,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.376817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.020517162676434,"pubTatorScore":1.7600863859081157,"self":"https://pharos.nih.gov/idg/api/v1/targets(3835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3835)/publications"},"_namespace":null},{"id":3836,"version":2,"created":1554880804000,"modified":1554880808000,"deprecated":false,"name":"Follistatin-related protein 1","accession":"Q12841","gene":"FSTL1","description":"May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.980381133167249,"antibodyCount":265,"monoclonalCount":23,"pubmedCount":null,"jensenScore":117.500442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.53893155379848,"pubTatorScore":1.7002240587341075,"self":"https://pharos.nih.gov/idg/api/v1/targets(3836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3836)/publications"},"_namespace":null},{"id":3837,"version":3,"created":1554880809000,"modified":1555035040000,"deprecated":false,"name":"Replication protein A 70 kDa DNA-binding subunit","accession":"P27694","gene":"RPA1","description":"As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.4827697822616424,"antibodyCount":350,"monoclonalCount":115,"pubmedCount":null,"jensenScore":297.924695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":51.55511973571242,"pubTatorScore":2.5856927511057703,"self":"https://pharos.nih.gov/idg/api/v1/targets(3837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":729,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/properties"},"_links":{"count":1335,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/links"},"_synonyms":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/synonyms"},"_publications":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(3837)/publications"},"_namespace":null},{"id":3838,"version":3,"created":1554880831000,"modified":1555035042000,"deprecated":false,"name":"DNA-(apurinic or apyrimidinic site) lyase","accession":"P27695","gene":"APEX1","description":"Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.4774644829533763,"antibodyCount":646,"monoclonalCount":152,"pubmedCount":null,"jensenScore":2988.977491,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.738231689575386,"pubTatorScore":3.0769839006505904,"self":"https://pharos.nih.gov/idg/api/v1/targets(3838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/properties"},"_links":{"count":1755,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/synonyms"},"_publications":{"count":527,"href":"https://pharos.nih.gov/idg/api/v1/targets(3838)/publications"},"_namespace":null},{"id":3839,"version":3,"created":1554880842000,"modified":1555035046000,"deprecated":false,"name":"Cadherin-related family member 2","accession":"Q9BYE9","gene":"CDHR2","description":"Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7236901795289912,"antibodyCount":30,"monoclonalCount":6,"pubmedCount":null,"jensenScore":6.090013,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":31.2564381999471,"pubTatorScore":0.7403626894942439,"self":"https://pharos.nih.gov/idg/api/v1/targets(3839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3839)/publications"},"_namespace":null},{"id":3840,"version":2,"created":1554880845000,"modified":1554880848000,"deprecated":false,"name":"G-rich sequence factor 1","accession":"Q12849","gene":"GRSF1","description":"Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0558528018184767,"antibodyCount":138,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.95564,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.56006171290958,"pubTatorScore":1.0848739982192874,"self":"https://pharos.nih.gov/idg/api/v1/targets(3840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3840)/publications"},"_namespace":null},{"id":3841,"version":3,"created":1554880849000,"modified":1555035049000,"deprecated":false,"name":"Polycomb group RING finger protein 6","accession":"Q9BYE7","gene":"PCGF6","description":"Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8267967682016752,"antibodyCount":112,"monoclonalCount":7,"pubmedCount":null,"jensenScore":8.452229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":32.38121829621317,"pubTatorScore":0.3708545435793626,"self":"https://pharos.nih.gov/idg/api/v1/targets(3841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3841)/publications"},"_namespace":null},{"id":3842,"version":3,"created":1554880851000,"modified":1555035050000,"deprecated":false,"name":"Syntaxin-4","accession":"Q12846","gene":"STX4","description":"Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9529472053968262,"antibodyCount":207,"monoclonalCount":50,"pubmedCount":null,"jensenScore":84.172062,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":44.57656170840945,"pubTatorScore":1.8746923328128302,"self":"https://pharos.nih.gov/idg/api/v1/targets(3842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3842)/publications"},"_namespace":null},{"id":3843,"version":2,"created":1554880856000,"modified":1554880857000,"deprecated":false,"name":"Transcription factor HES-7","accession":"Q9BYE0","gene":"HES7","description":"Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3604699838556964,"antibodyCount":144,"monoclonalCount":0,"pubmedCount":null,"jensenScore":22.625486,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.004540012882845,"pubTatorScore":1.1937814172577421,"self":"https://pharos.nih.gov/idg/api/v1/targets(3843)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3843)/publications"},"_namespace":null},{"id":3844,"version":2,"created":1554880858000,"modified":1554880861000,"deprecated":false,"name":"Nuclear receptor subfamily 2 group C member 1","accession":"P13056","gene":"NR2C1","description":"Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.","idgFamily":"Nuclear Receptor","idgTDL":"Tbio","novelty":-1.391823896267129,"antibodyCount":294,"monoclonalCount":99,"pubmedCount":null,"jensenScore":24.356992,"patentCount":15193,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.72387488611102,"pubTatorScore":1.9394325398147267,"self":"https://pharos.nih.gov/idg/api/v1/targets(3844)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3844)/publications"},"_namespace":null},{"id":3845,"version":3,"created":1554880861000,"modified":1555035051000,"deprecated":false,"name":"Serine/threonine-protein kinase receptor R3","accession":"P37023","gene":"ACVRL1","description":"Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.9837022431853213,"antibodyCount":432,"monoclonalCount":103,"pubmedCount":null,"jensenScore":969.840322,"patentCount":38459,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.15884508689677,"pubTatorScore":2.4093319006630884,"self":"https://pharos.nih.gov/idg/api/v1/targets(3845)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":550,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/properties"},"_links":{"count":1116,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/synonyms"},"_publications":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(3845)/publications"},"_namespace":null},{"id":3846,"version":3,"created":1554880887000,"modified":1555035053000,"deprecated":false,"name":"Carboxypeptidase M","accession":"P14384","gene":"CPM","description":"Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.144740165864397,"antibodyCount":196,"monoclonalCount":33,"pubmedCount":null,"jensenScore":133.188197,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.377709575265975,"pubTatorScore":1.7888751087137178,"self":"https://pharos.nih.gov/idg/api/v1/targets(3846)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3846)/publications"},"_namespace":null},{"id":3847,"version":2,"created":1554880892000,"modified":1554880896000,"deprecated":false,"name":"Acidic leucine-rich nuclear phosphoprotein 32 family member A","accession":"P39687","gene":"ANP32A","description":"Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1609891804207404,"antibodyCount":382,"monoclonalCount":58,"pubmedCount":null,"jensenScore":153.605903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.4173501199152,"pubTatorScore":1.918781058975526,"self":"https://pharos.nih.gov/idg/api/v1/targets(3847)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3847)/publications"},"_namespace":null},{"id":3848,"version":2,"created":1554880897000,"modified":1554880902000,"deprecated":false,"name":"Uracil-DNA glycosylase","accession":"P13051","gene":"UNG","description":"Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.8295681214594923,"antibodyCount":352,"monoclonalCount":119,"pubmedCount":null,"jensenScore":680.854469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.303815537405676,"pubTatorScore":2.6683525707268707,"self":"https://pharos.nih.gov/idg/api/v1/targets(3848)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/properties"},"_links":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/synonyms"},"_publications":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3848)/publications"},"_namespace":null},{"id":3849,"version":2,"created":1554880903000,"modified":1554880904000,"deprecated":false,"name":"Small proline-rich protein 2G","accession":"Q9BYE4","gene":"SPRR2G","description":"Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.39222014925042364,"antibodyCount":1,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.305195,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.15302796143528,"pubTatorScore":-0.0917708076503444,"self":"https://pharos.nih.gov/idg/api/v1/targets(3849)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/properties"},"_links":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3849)/publications"},"_namespace":null},{"id":3850,"version":2,"created":1554880904000,"modified":1554880906000,"deprecated":false,"name":"Late cornified envelope protein 3D","accession":"Q9BYE3","gene":"LCE3D","description":"Precursors of the cornified envelope of the stratum corneum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.13175072010915284,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.113967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.116187403946512,"pubTatorScore":0.06356264493942214,"self":"https://pharos.nih.gov/idg/api/v1/targets(3850)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/properties"},"_links":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3850)/publications"},"_namespace":null},{"id":3851,"version":2,"created":1554880906000,"modified":1554880908000,"deprecated":false,"name":"Transmembrane protease serine 13","accession":"Q9BYE2","gene":"TMPRSS13","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7763426239123632,"antibodyCount":71,"monoclonalCount":6,"pubmedCount":null,"jensenScore":56.800298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.53831260571199,"pubTatorScore":1.5429439147012267,"self":"https://pharos.nih.gov/idg/api/v1/targets(3851)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3851)/publications"},"_namespace":null},{"id":3852,"version":3,"created":1554880908000,"modified":1554881052000,"deprecated":false,"name":"C-X-C chemokine receptor type 2","accession":"P25025","gene":"CXCR2","description":"Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.8731318593663167,"antibodyCount":643,"monoclonalCount":288,"pubmedCount":null,"jensenScore":723.905403,"patentCount":57672,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.614421934844756,"pubTatorScore":2.665099198225467,"self":"https://pharos.nih.gov/idg/api/v1/targets(3852)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":633,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/properties"},"_links":{"count":1490,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/synonyms"},"_publications":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(3852)/publications"},"_namespace":null},{"id":3853,"version":2,"created":1554881055000,"modified":1554881064000,"deprecated":false,"name":"DNA (cytosine-5)-methyltransferase 1","accession":"P26358","gene":"DNMT1","description":"Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.2133266443361292,"antibodyCount":1125,"monoclonalCount":325,"pubmedCount":null,"jensenScore":1562.73974,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":58.04646512078766,"pubTatorScore":2.990927054530312,"self":"https://pharos.nih.gov/idg/api/v1/targets(3853)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(3853)/properties"},"_links":{"count":1561,"href":"https://pharos.nih.gov/idg/api/v1/targets(3853)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(3853)/synonyms"},"_publications":{"count":475,"href":"https://pharos.nih.gov/idg/api/v1/targets(3853)/publications"},"_namespace":null},{"id":3854,"version":2,"created":1554881066000,"modified":1554881071000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase kinase 2","accession":"Q12851","gene":"MAP4K2","description":"Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.6042301015965006,"antibodyCount":193,"monoclonalCount":3,"pubmedCount":null,"jensenScore":35.275727,"patentCount":9397,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.31730898005464,"pubTatorScore":0.8687423346143607,"self":"https://pharos.nih.gov/idg/api/v1/targets(3854)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3854)/publications"},"_namespace":null},{"id":3855,"version":2,"created":1554881072000,"modified":1554881074000,"deprecated":false,"name":"Rab proteins geranylgeranyltransferase component A 2","accession":"P26374","gene":"CHML","description":"Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9013739231619304,"antibodyCount":126,"monoclonalCount":12,"pubmedCount":null,"jensenScore":73.297913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.56396952166738,"pubTatorScore":1.5624653581411643,"self":"https://pharos.nih.gov/idg/api/v1/targets(3855)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3855)/publications"},"_namespace":null},{"id":3856,"version":3,"created":1554881075000,"modified":1554881214000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 12","accession":"Q12852","gene":"MAP3K12","description":"May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.0644030631343,"antibodyCount":134,"monoclonalCount":26,"pubmedCount":null,"jensenScore":120.96298,"patentCount":19919,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.04656861347162,"pubTatorScore":1.8868227545336373,"self":"https://pharos.nih.gov/idg/api/v1/targets(3856)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(3856)/properties"},"_links":{"count":1374,"href":"https://pharos.nih.gov/idg/api/v1/targets(3856)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3856)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(3856)/publications"},"_namespace":null},{"id":3857,"version":2,"created":1554881216000,"modified":1554881218000,"deprecated":false,"name":"Lysophospholipid acyltransferase 5","accession":"Q6P1A2","gene":"LPCAT3","description":"Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2177072941443816,"antibodyCount":32,"monoclonalCount":8,"pubmedCount":null,"jensenScore":162.798027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.619678135385136,"pubTatorScore":1.8816699019689165,"self":"https://pharos.nih.gov/idg/api/v1/targets(3857)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(3857)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(3857)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3857)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3857)/publications"},"_namespace":null},{"id":3858,"version":2,"created":1554881219000,"modified":1554881220000,"deprecated":false,"name":"Keratin-associated protein 5-9","accession":"P26371","gene":"KRTAP5-9","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4393326981732075,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.916667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.112572776527776,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(3858)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/properties"},"_links":{"count":680,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3858)/publications"},"_namespace":null},{"id":3859,"version":3,"created":1554881221000,"modified":1555035055000,"deprecated":false,"name":"60S ribosomal protein L13","accession":"P26373","gene":"RPL13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5533149867260796,"antibodyCount":96,"monoclonalCount":12,"pubmedCount":null,"jensenScore":34.990386,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":42.694659989651264,"pubTatorScore":1.2968218808842387,"self":"https://pharos.nih.gov/idg/api/v1/targets(3859)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/properties"},"_links":{"count":1157,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3859)/publications"},"_namespace":null},{"id":3860,"version":2,"created":1554881225000,"modified":1554881227000,"deprecated":false,"name":"39S ribosomal protein L1, mitochondrial","accession":"Q9BYD6","gene":"MRPL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7444817778719438,"antibodyCount":128,"monoclonalCount":12,"pubmedCount":null,"jensenScore":4.180123,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.11503667096846,"pubTatorScore":0.08184901334835865,"self":"https://pharos.nih.gov/idg/api/v1/targets(3860)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3860)/publications"},"_namespace":null},{"id":3861,"version":2,"created":1554881228000,"modified":1554881232000,"deprecated":false,"name":"Nuclear factor 1 A-type","accession":"Q12857","gene":"NFIA","description":"Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8060229614853802,"antibodyCount":163,"monoclonalCount":25,"pubmedCount":null,"jensenScore":47.376928,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.333435294169625,"pubTatorScore":1.5883454353809943,"self":"https://pharos.nih.gov/idg/api/v1/targets(3861)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(3861)/properties"},"_links":{"count":1155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3861)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(3861)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3861)/publications"},"_namespace":null},{"id":3862,"version":2,"created":1554881232000,"modified":1554881234000,"deprecated":false,"name":"Cornifelin","accession":"Q9BYD5","gene":"CNFN","description":"Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5600205470806973,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.817094,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.735313954171048,"pubTatorScore":0.42596862369864713,"self":"https://pharos.nih.gov/idg/api/v1/targets(3862)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3862)/properties"},"_links":{"count":748,"href":"https://pharos.nih.gov/idg/api/v1/targets(3862)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3862)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3862)/publications"},"_namespace":null},{"id":3863,"version":3,"created":1554881235000,"modified":1555035057000,"deprecated":false,"name":"Actin-related protein T3","accession":"Q9BYD9","gene":"ACTRT3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.051152521904513165,"antibodyCount":87,"monoclonalCount":6,"pubmedCount":null,"jensenScore":1.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":17.823548018356146,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(3863)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(3863)/properties"},"_links":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(3863)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3863)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3863)/publications"},"_namespace":null},{"id":3864,"version":2,"created":1554881237000,"modified":1554881240000,"deprecated":false,"name":"Protein bassoon","accession":"Q9UPA5","gene":"BSN","description":"Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0580515114482907,"antibodyCount":84,"monoclonalCount":8,"pubmedCount":null,"jensenScore":1116.172441,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.722723754758924,"pubTatorScore":1.623003016974655,"self":"https://pharos.nih.gov/idg/api/v1/targets(3864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(3864)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(3864)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3864)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(3864)/publications"},"_namespace":null},{"id":3865,"version":3,"created":1554881241000,"modified":1555035060000,"deprecated":false,"name":"39S ribosomal protein L4, mitochondrial","accession":"Q9BYD3","gene":"MRPL4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":66,"monoclonalCount":18,"pubmedCount":null,"jensenScore":1.055556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":73,"knowledgeAvailability":36.96527990327563,"pubTatorScore":0.014240299019593509,"self":"https://pharos.nih.gov/idg/api/v1/targets(3865)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(3865)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3865)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3865)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3865)/publications"},"_namespace":null},{"id":3866,"version":2,"created":1554881244000,"modified":1554881246000,"deprecated":false,"name":"39S ribosomal protein L9, mitochondrial","accession":"Q9BYD2","gene":"MRPL9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0,"antibodyCount":133,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.047619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.15597233553256,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3866)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(3866)/properties"},"_links":{"count":1104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3866)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3866)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3866)/publications"},"_namespace":null},{"id":3867,"version":3,"created":1554881247000,"modified":1555035062000,"deprecated":false,"name":"39S ribosomal protein L13, mitochondrial","accession":"Q9BYD1","gene":"MRPL13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9065678428632057,"antibodyCount":104,"monoclonalCount":17,"pubmedCount":null,"jensenScore":8.976104,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":36.696097001461865,"pubTatorScore":1.3335272337482542,"self":"https://pharos.nih.gov/idg/api/v1/targets(3867)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(3867)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(3867)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(3867)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3867)/publications"},"_namespace":null},{"id":3868,"version":3,"created":1554881250000,"modified":1555035064000,"deprecated":false,"name":"Splicing factor U2AF 65 kDa subunit","accession":"P26368","gene":"U2AF2","description":"Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1404300255681714,"antibodyCount":183,"monoclonalCount":21,"pubmedCount":null,"jensenScore":127.82184,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":41.075760103362796,"pubTatorScore":2.090907770092461,"self":"https://pharos.nih.gov/idg/api/v1/targets(3868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":526,"href":"https://pharos.nih.gov/idg/api/v1/targets(3868)/properties"},"_links":{"count":1243,"href":"https://pharos.nih.gov/idg/api/v1/targets(3868)/links"},"_synonyms":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(3868)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3868)/publications"},"_namespace":null},{"id":3869,"version":2,"created":1554881256000,"modified":1554881261000,"deprecated":false,"name":"Paired box protein Pax-6","accession":"P26367","gene":"PAX6","description":"Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.1665022778666434,"antibodyCount":570,"monoclonalCount":185,"pubmedCount":null,"jensenScore":1458.566993,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.32776155060298,"pubTatorScore":2.906275171854608,"self":"https://pharos.nih.gov/idg/api/v1/targets(3869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":666,"href":"https://pharos.nih.gov/idg/api/v1/targets(3869)/properties"},"_links":{"count":1260,"href":"https://pharos.nih.gov/idg/api/v1/targets(3869)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(3869)/synonyms"},"_publications":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(3869)/publications"},"_namespace":null},{"id":3870,"version":2,"created":1554881263000,"modified":1554881266000,"deprecated":false,"name":"SH3 and PX domain-containing protein 2A","accession":"Q5TCZ1","gene":"SH3PXD2A","description":"Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4770979771592654,"antibodyCount":110,"monoclonalCount":2,"pubmedCount":null,"jensenScore":30.689268,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.734489163877406,"pubTatorScore":1.426052912098732,"self":"https://pharos.nih.gov/idg/api/v1/targets(3870)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(3870)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(3870)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3870)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3870)/publications"},"_namespace":null},{"id":3871,"version":3,"created":1554881267000,"modified":1555035066000,"deprecated":false,"name":"Signal transducer and activator of transcription 2","accession":"P52630","gene":"STAT2","description":"Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.431269228540106,"antibodyCount":691,"monoclonalCount":95,"pubmedCount":null,"jensenScore":248.770909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":48.71279240193035,"pubTatorScore":2.2951833836012745,"self":"https://pharos.nih.gov/idg/api/v1/targets(3871)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":552,"href":"https://pharos.nih.gov/idg/api/v1/targets(3871)/properties"},"_links":{"count":1135,"href":"https://pharos.nih.gov/idg/api/v1/targets(3871)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3871)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(3871)/publications"},"_namespace":null},{"id":3872,"version":3,"created":1554881273000,"modified":1555035069000,"deprecated":false,"name":"Beta-adrenergic receptor kinase 1","accession":"P25098","gene":"GRK2","description":"Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.6104264018637,"antibodyCount":455,"monoclonalCount":84,"pubmedCount":null,"jensenScore":428.839677,"patentCount":12829,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":2.5859809451337323,"self":"https://pharos.nih.gov/idg/api/v1/targets(3872)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":632,"href":"https://pharos.nih.gov/idg/api/v1/targets(3872)/properties"},"_links":{"count":1191,"href":"https://pharos.nih.gov/idg/api/v1/targets(3872)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3872)/synonyms"},"_publications":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(3872)/publications"},"_namespace":null},{"id":3873,"version":2,"created":1554881293000,"modified":1554881296000,"deprecated":false,"name":"Contactin-1","accession":"Q12860","gene":"CNTN1","description":"Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9301650979783584,"antibodyCount":211,"monoclonalCount":14,"pubmedCount":null,"jensenScore":87.567339,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.713649251472006,"pubTatorScore":1.6543273343255935,"self":"https://pharos.nih.gov/idg/api/v1/targets(3873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3873)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(3873)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(3873)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3873)/publications"},"_namespace":null},{"id":3874,"version":2,"created":1554881297000,"modified":1554881325000,"deprecated":false,"name":"Tyrosine-protein kinase Mer","accession":"Q12866","gene":"MERTK","description":"Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.272762204476896,"antibodyCount":609,"monoclonalCount":164,"pubmedCount":null,"jensenScore":199.074683,"patentCount":31823,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.46389256994732,"pubTatorScore":2.0737895724657323,"self":"https://pharos.nih.gov/idg/api/v1/targets(3874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(3874)/properties"},"_links":{"count":1206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3874)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3874)/synonyms"},"_publications":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3874)/publications"},"_namespace":null},{"id":3875,"version":3,"created":1554881326000,"modified":1555035072000,"deprecated":false,"name":"Calcium signal-modulating cyclophilin ligand","accession":"P49069","gene":"CAMLG","description":"Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9117561487335173,"antibodyCount":147,"monoclonalCount":29,"pubmedCount":null,"jensenScore":78.821717,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.40055475200465,"pubTatorScore":1.5930089940546166,"self":"https://pharos.nih.gov/idg/api/v1/targets(3875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(3875)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(3875)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3875)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3875)/publications"},"_namespace":null},{"id":3876,"version":3,"created":1554881329000,"modified":1555035073000,"deprecated":false,"name":"Zinc finger protein 816","accession":"Q0VGE8","gene":"ZNF816","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.12014517601415686,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.357143,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":24.55788543450544,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(3876)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(3876)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3876)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3876)/publications"},"_namespace":null},{"id":3877,"version":2,"created":1554881332000,"modified":1554881336000,"deprecated":false,"name":"Cadherin-17","accession":"Q12864","gene":"CDH17","description":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.382192663338032,"antibodyCount":312,"monoclonalCount":141,"pubmedCount":null,"jensenScore":2005.505292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.503449821613348,"pubTatorScore":1.902234219436388,"self":"https://pharos.nih.gov/idg/api/v1/targets(3877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(3877)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(3877)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3877)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3877)/publications"},"_namespace":null},{"id":3878,"version":3,"created":1554881337000,"modified":1555035075000,"deprecated":false,"name":"N-formyl peptide receptor 2","accession":"P25090","gene":"FPR2","description":"Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.491467587737952,"antibodyCount":253,"monoclonalCount":64,"pubmedCount":null,"jensenScore":330.926296,"patentCount":28058,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":71,"knowledgeAvailability":31.520770838367646,"pubTatorScore":2.344430727678182,"self":"https://pharos.nih.gov/idg/api/v1/targets(3878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(3878)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(3878)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(3878)/synonyms"},"_publications":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(3878)/publications"},"_namespace":null},{"id":3879,"version":2,"created":1554881348000,"modified":1554881351000,"deprecated":false,"name":"Zinc finger protein 383","accession":"Q8NA42","gene":"ZNF383","description":"May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":59,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.818182,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.734883039641236,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(3879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3879)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(3879)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3879)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(3879)/publications"},"_namespace":null},{"id":3880,"version":2,"created":1554881351000,"modified":1554881359000,"deprecated":false,"name":"Heat-stable enterotoxin receptor","accession":"P25092","gene":"GUCY2C","description":"Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.3349417900839193,"antibodyCount":228,"monoclonalCount":182,"pubmedCount":null,"jensenScore":214.458069,"patentCount":28673,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.53147368417409,"pubTatorScore":2.4788301131189874,"self":"https://pharos.nih.gov/idg/api/v1/targets(3880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(3880)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(3880)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3880)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3880)/publications"},"_namespace":null},{"id":3881,"version":2,"created":1554881360000,"modified":1554881361000,"deprecated":false,"name":"Coiled-coil domain-containing protein 63","accession":"Q8NA47","gene":"CCDC63","description":"Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8944743171544594,"antibodyCount":106,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.715151,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.937879573791891,"pubTatorScore":0.7277735505740713,"self":"https://pharos.nih.gov/idg/api/v1/targets(3881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(3881)/properties"},"_links":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(3881)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(3881)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3881)/publications"},"_namespace":null},{"id":3882,"version":3,"created":1554881361000,"modified":1555035077000,"deprecated":false,"name":"Amiloride-sensitive sodium channel subunit alpha","accession":"P37088","gene":"SCNN1A","description":"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.842727022346807,"antibodyCount":184,"monoclonalCount":2,"pubmedCount":null,"jensenScore":63.213471,"patentCount":3641,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.036599138797634,"pubTatorScore":2.115831456443083,"self":"https://pharos.nih.gov/idg/api/v1/targets(3882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(3882)/properties"},"_links":{"count":1193,"href":"https://pharos.nih.gov/idg/api/v1/targets(3882)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(3882)/synonyms"},"_publications":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(3882)/publications"},"_namespace":null},{"id":3883,"version":2,"created":1554881383000,"modified":1554881385000,"deprecated":false,"name":"Protein FAM214A","accession":"Q32MH5","gene":"FAM214A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.17550700398161,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(3883)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(3883)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3883)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3883)/publications"},"_namespace":null},{"id":3884,"version":2,"created":1554881386000,"modified":1554881388000,"deprecated":false,"name":"Helicase with zinc finger domain 2","accession":"Q9BYK8","gene":"HELZ2","description":"Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5084859935811757,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.266084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.84250864559632,"pubTatorScore":0.4141005418236614,"self":"https://pharos.nih.gov/idg/api/v1/targets(3884)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(3884)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(3884)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3884)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3884)/publications"},"_namespace":null},{"id":3885,"version":2,"created":1554881388000,"modified":1554881390000,"deprecated":false,"name":"Transcription factor 15","accession":"Q12870","gene":"TCF15","description":"May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.457587909409625,"antibodyCount":70,"monoclonalCount":0,"pubmedCount":null,"jensenScore":267.341284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.0424350582133,"pubTatorScore":1.8336782142525379,"self":"https://pharos.nih.gov/idg/api/v1/targets(3885)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3885)/properties"},"_links":{"count":708,"href":"https://pharos.nih.gov/idg/api/v1/targets(3885)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3885)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3885)/publications"},"_namespace":null},{"id":3886,"version":2,"created":1554881390000,"modified":1554881393000,"deprecated":false,"name":"Chromodomain-helicase-DNA-binding protein 3","accession":"Q12873","gene":"CHD3","description":"Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.9563269490927457,"antibodyCount":190,"monoclonalCount":107,"pubmedCount":null,"jensenScore":85.175123,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.42999316799706,"pubTatorScore":1.8161298145564178,"self":"https://pharos.nih.gov/idg/api/v1/targets(3886)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(3886)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(3886)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(3886)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3886)/publications"},"_namespace":null},{"id":3887,"version":3,"created":1554881394000,"modified":1555035079000,"deprecated":false,"name":"Splicing factor 3A subunit 3","accession":"Q12874","gene":"SF3A3","description":"Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.295176590782753,"antibodyCount":78,"monoclonalCount":11,"pubmedCount":null,"jensenScore":20.117023,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.122804151794085,"pubTatorScore":0.9540981066472801,"self":"https://pharos.nih.gov/idg/api/v1/targets(3887)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3887)/publications"},"_namespace":null},{"id":3888,"version":3,"created":1554881398000,"modified":1555035080000,"deprecated":false,"name":"Splicing factor, suppressor of white-apricot homolog","accession":"Q12872","gene":"SFSWAP","description":"Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3979400086720376,"antibodyCount":147,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.818507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":40.46794380182579,"pubTatorScore":1.2409650483752852,"self":"https://pharos.nih.gov/idg/api/v1/targets(3888)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3888)/publications"},"_namespace":null},{"id":3889,"version":2,"created":1554881401000,"modified":1554881404000,"deprecated":false,"name":"Ral GTPase-activating protein subunit alpha-1","accession":"Q6GYQ0","gene":"RALGAPA1","description":"Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.56324247486823,"antibodyCount":56,"monoclonalCount":12,"pubmedCount":null,"jensenScore":36.816583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.06571876803404,"pubTatorScore":1.0380900628690395,"self":"https://pharos.nih.gov/idg/api/v1/targets(3889)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3889)/publications"},"_namespace":null},{"id":3890,"version":2,"created":1554881405000,"modified":1554881408000,"deprecated":false,"name":"Telomere repeats-binding bouquet formation protein 1","accession":"Q8NA31","gene":"TERB1","description":"Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.45229766665168547,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.562467,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3890)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/properties"},"_links":{"count":712,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3890)/publications"},"_namespace":null},{"id":3891,"version":3,"created":1554881408000,"modified":1555035083000,"deprecated":false,"name":"Glutamate receptor ionotropic, NMDA 2A","accession":"Q12879","gene":"GRIN2A","description":"Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-3.0982801998050182,"antibodyCount":555,"monoclonalCount":164,"pubmedCount":null,"jensenScore":1158.102031,"patentCount":14768,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":51.94187303312502,"pubTatorScore":2.6031651262019975,"self":"https://pharos.nih.gov/idg/api/v1/targets(3891)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/synonyms"},"_publications":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(3891)/publications"},"_namespace":null},{"id":3892,"version":2,"created":1554881416000,"modified":1554881418000,"deprecated":false,"name":"Tripartite motif-containing protein 34","accession":"Q9BYJ4","gene":"TRIM34","description":"May function as antiviral protein and may contribute to the defense against retroviral infections.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2018520875422818,"antibodyCount":78,"monoclonalCount":4,"pubmedCount":null,"jensenScore":9.984038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.164050739322487,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(3892)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/properties"},"_links":{"count":727,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3892)/publications"},"_namespace":null},{"id":3893,"version":2,"created":1554881419000,"modified":1554881421000,"deprecated":false,"name":"Sodium-dependent lysophosphatidylcholine symporter 1","accession":"Q8NA29","gene":"MFSD2A","description":"Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:26005868). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed:21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732, PubMed:23177091).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4017514413102814,"antibodyCount":73,"monoclonalCount":2,"pubmedCount":null,"jensenScore":26.333181,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.08957126560373,"pubTatorScore":1.562670393734591,"self":"https://pharos.nih.gov/idg/api/v1/targets(3893)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(3893)/publications"},"_namespace":null},{"id":3894,"version":3,"created":1554881422000,"modified":1555035084000,"deprecated":false,"name":"YTH domain-containing family protein 1","accession":"Q9BYJ9","gene":"YTHDF1","description":"Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7648519040170976,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.255195,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.36241041882738,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(3894)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/properties"},"_links":{"count":929,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3894)/publications"},"_namespace":null},{"id":3895,"version":3,"created":1554881425000,"modified":1555035086000,"deprecated":false,"name":"Hydroperoxide isomerase ALOXE3","accession":"Q9BYJ1","gene":"ALOXE3","description":"Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.511199213168452,"antibodyCount":118,"monoclonalCount":2,"pubmedCount":null,"jensenScore":32.190304,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":31.75114930771382,"pubTatorScore":1.3855566039117873,"self":"https://pharos.nih.gov/idg/api/v1/targets(3895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/properties"},"_links":{"count":824,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3895)/publications"},"_namespace":null},{"id":3896,"version":2,"created":1554881428000,"modified":1554881430000,"deprecated":false,"name":"Fibroblast growth factor-binding protein 2","accession":"Q9BYJ0","gene":"FGFBP2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8021720520296401,"antibodyCount":63,"monoclonalCount":4,"pubmedCount":null,"jensenScore":7.36045,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.524781665224467,"pubTatorScore":0.9022941192927291,"self":"https://pharos.nih.gov/idg/api/v1/targets(3896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3896)/publications"},"_namespace":null},{"id":3897,"version":2,"created":1554881430000,"modified":1554881460000,"deprecated":false,"name":"Prolyl endopeptidase FAP","accession":"Q12884","gene":"FAP","description":"Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3768644682926006,"antibodyCount":406,"monoclonalCount":70,"pubmedCount":null,"jensenScore":226.211055,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.204481222187184,"pubTatorScore":2.4180636158279176,"self":"https://pharos.nih.gov/idg/api/v1/targets(3897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(3897)/publications"},"_namespace":null},{"id":3898,"version":2,"created":1554881461000,"modified":1554881469000,"deprecated":false,"name":"Dihydropyrimidine dehydrogenase [NADP(+)]","accession":"Q12882","gene":"DPYD","description":"Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.6243181003406253,"antibodyCount":159,"monoclonalCount":28,"pubmedCount":null,"jensenScore":395.040854,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.82179117493261,"pubTatorScore":2.9352470056604907,"self":"https://pharos.nih.gov/idg/api/v1/targets(3898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/properties"},"_links":{"count":1197,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(3898)/publications"},"_namespace":null},{"id":3899,"version":2,"created":1554881471000,"modified":1554881472000,"deprecated":false,"name":"Aminopeptidase Q","accession":"Q6Q4G3","gene":"LVRN","description":"Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9310783172933055,"antibodyCount":15,"monoclonalCount":1,"pubmedCount":null,"jensenScore":81.302588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.687432273123182,"pubTatorScore":1.1865207778526312,"self":"https://pharos.nih.gov/idg/api/v1/targets(3899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3899)/publications"},"_namespace":null},{"id":3900,"version":2,"created":1554881473000,"modified":1554881478000,"deprecated":false,"name":"TP53-binding protein 1","accession":"Q12888","gene":"TP53BP1","description":"Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.694850775022812,"antibodyCount":577,"monoclonalCount":104,"pubmedCount":null,"jensenScore":464.845443,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.04183098347208,"pubTatorScore":2.4859846370241807,"self":"https://pharos.nih.gov/idg/api/v1/targets(3900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":689,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/properties"},"_links":{"count":1363,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/synonyms"},"_publications":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(3900)/publications"},"_namespace":null},{"id":3901,"version":3,"created":1554881479000,"modified":1555035087000,"deprecated":false,"name":"Radial spoke head protein 4 homolog A","accession":"Q5TD94","gene":"RSPH4A","description":"Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7881683698382842,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.471551,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.503001744222786,"pubTatorScore":0.7420134206928494,"self":"https://pharos.nih.gov/idg/api/v1/targets(3901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3901)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(3901)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(3901)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3901)/publications"},"_namespace":null},{"id":3902,"version":3,"created":1554881482000,"modified":1555035088000,"deprecated":false,"name":"Oviduct-specific glycoprotein","accession":"Q12889","gene":"OVGP1","description":"Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2684015660270456,"antibodyCount":67,"monoclonalCount":7,"pubmedCount":null,"jensenScore":185.935149,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":30.934643626892424,"pubTatorScore":1.8752680194100657,"self":"https://pharos.nih.gov/idg/api/v1/targets(3902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(3902)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(3902)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3902)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3902)/publications"},"_namespace":null},{"id":3903,"version":2,"created":1554881485000,"modified":1554881488000,"deprecated":false,"name":"Protoheme IX farnesyltransferase, mitochondrial","accession":"Q12887","gene":"COX10","description":"Converts protoheme IX and farnesyl diphosphate to heme O.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6026639066376194,"antibodyCount":154,"monoclonalCount":2,"pubmedCount":null,"jensenScore":40.911798,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.82903826881259,"pubTatorScore":1.3965506869662623,"self":"https://pharos.nih.gov/idg/api/v1/targets(3903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(3903)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(3903)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3903)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(3903)/publications"},"_namespace":null},{"id":3904,"version":2,"created":1554881489000,"modified":1554881491000,"deprecated":false,"name":"WD repeat-containing protein 31","accession":"Q8NA23","gene":"WDR31","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":22,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.285226430698255,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(3904)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(3904)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3904)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3904)/publications"},"_namespace":null},{"id":3905,"version":4,"created":1554881491000,"modified":1555035090000,"deprecated":false,"name":"Estradiol 17-beta-dehydrogenase 2","accession":"P37059","gene":"HSD17B2","description":"Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.9262842151140904,"antibodyCount":209,"monoclonalCount":16,"pubmedCount":null,"jensenScore":78.766358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.623055493270368,"pubTatorScore":1.9731613207061944,"self":"https://pharos.nih.gov/idg/api/v1/targets(3905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(3905)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(3905)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(3905)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3905)/publications"},"_namespace":null},{"id":3906,"version":3,"created":1554881547000,"modified":1555035092000,"deprecated":false,"name":"Transcription initiation factor IIA subunit 2","accession":"P52657","gene":"GTF2A2","description":"TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1868823725540543,"antibodyCount":42,"monoclonalCount":6,"pubmedCount":null,"jensenScore":16.539341,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":34.72966411346799,"pubTatorScore":0.988066774936856,"self":"https://pharos.nih.gov/idg/api/v1/targets(3906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(3906)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(3906)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3906)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(3906)/publications"},"_namespace":null},{"id":3907,"version":2,"created":1554881551000,"modified":1554881578000,"deprecated":false,"name":"Monocarboxylate transporter 1","accession":"P53985","gene":"SLC16A1","description":"Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.460593912592388,"antibodyCount":236,"monoclonalCount":9,"pubmedCount":null,"jensenScore":294.180747,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.07508021206685,"pubTatorScore":2.455120914971801,"self":"https://pharos.nih.gov/idg/api/v1/targets(3907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(3907)/properties"},"_links":{"count":1267,"href":"https://pharos.nih.gov/idg/api/v1/targets(3907)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(3907)/synonyms"},"_publications":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(3907)/publications"},"_namespace":null},{"id":3908,"version":3,"created":1554881580000,"modified":1555035093000,"deprecated":false,"name":"Transcription initiation factor IIA subunit 1","accession":"P52655","gene":"GTF2A1","description":"TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-0.11089565772454141,"antibodyCount":246,"monoclonalCount":24,"pubmedCount":null,"jensenScore":1.063809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":45.25231705876028,"pubTatorScore":1.8843118616078145,"self":"https://pharos.nih.gov/idg/api/v1/targets(3908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(3908)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(3908)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3908)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3908)/publications"},"_namespace":null},{"id":3909,"version":2,"created":1554881585000,"modified":1554881587000,"deprecated":false,"name":"Lethal(3)malignant brain tumor-like protein 4","accession":"Q8NA19","gene":"L3MBTL4","description":"Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-0.21307482386120297,"antibodyCount":90,"monoclonalCount":26,"pubmedCount":null,"jensenScore":2.312122,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.861227148337445,"pubTatorScore":0.36382080464389377,"self":"https://pharos.nih.gov/idg/api/v1/targets(3909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(3909)/properties"},"_links":{"count":838,"href":"https://pharos.nih.gov/idg/api/v1/targets(3909)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3909)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3909)/publications"},"_namespace":null},{"id":3910,"version":3,"created":1554881588000,"modified":1555035095000,"deprecated":false,"name":"Breast cancer type 1 susceptibility protein","accession":"P38398","gene":"BRCA1","description":"E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.767842811512566,"antibodyCount":1542,"monoclonalCount":466,"pubmedCount":null,"jensenScore":6081.275325,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":68.18849343699536,"pubTatorScore":3.808160009225213,"self":"https://pharos.nih.gov/idg/api/v1/targets(3910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":3054,"href":"https://pharos.nih.gov/idg/api/v1/targets(3910)/properties"},"_links":{"count":3127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3910)/links"},"_synonyms":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(3910)/synonyms"},"_publications":{"count":2467,"href":"https://pharos.nih.gov/idg/api/v1/targets(3910)/publications"},"_namespace":null},{"id":3911,"version":3,"created":1554881610000,"modified":1555035107000,"deprecated":false,"name":"Hyccin","accession":"Q9BYI3","gene":"FAM126A","description":"Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9530920424361135,"antibodyCount":51,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.494372,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.708085849395026,"pubTatorScore":1.136984645678016,"self":"https://pharos.nih.gov/idg/api/v1/targets(3911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3911)/publications"},"_namespace":null},{"id":3912,"version":3,"created":1554881614000,"modified":1555035108000,"deprecated":false,"name":"Four and a half LIM domains protein 5","accession":"Q5TD97","gene":"FHL5","description":"May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6056641231245588,"antibodyCount":116,"monoclonalCount":27,"pubmedCount":null,"jensenScore":3.426353,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":23.16347039190191,"pubTatorScore":0.8772615487976884,"self":"https://pharos.nih.gov/idg/api/v1/targets(3912)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(3912)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(3912)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3912)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3912)/publications"},"_namespace":null},{"id":3913,"version":2,"created":1554881617000,"modified":1554881619000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 21","accession":"Q5TCX8","gene":"MAP3K21","description":"Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.","idgFamily":"Kinase","idgTDL":"Tdark","novelty":-0.42420258412517714,"antibodyCount":174,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.23561,"patentCount":3444,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6117483668192777,"self":"https://pharos.nih.gov/idg/api/v1/targets(3913)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(3913)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(3913)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3913)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3913)/publications"},"_namespace":null},{"id":3914,"version":2,"created":1554881619000,"modified":1554881621000,"deprecated":false,"name":"Selenoprotein W","accession":"P63302","gene":"SELENOW","description":"Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.831266871065921,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":70.655029,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.2795091871251392,"self":"https://pharos.nih.gov/idg/api/v1/targets(3914)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(3914)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(3914)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3914)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3914)/publications"},"_namespace":null},{"id":3915,"version":3,"created":1554881622000,"modified":1555035109000,"deprecated":false,"name":"Hyaluronidase-2","accession":"Q12891","gene":"HYAL2","description":"Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0142417564765367,"antibodyCount":212,"monoclonalCount":3,"pubmedCount":null,"jensenScore":105.071057,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.12919647997593,"pubTatorScore":1.8773811087460714,"self":"https://pharos.nih.gov/idg/api/v1/targets(3915)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(3915)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(3915)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3915)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3915)/publications"},"_namespace":null},{"id":3916,"version":2,"created":1554881625000,"modified":1554881628000,"deprecated":false,"name":"Tau-tubulin kinase 1","accession":"Q5TCY1","gene":"TTBK1","description":"Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.1171541006006906,"antibodyCount":161,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.088384,"patentCount":2177,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.816280824981064,"pubTatorScore":1.0513864380062568,"self":"https://pharos.nih.gov/idg/api/v1/targets(3916)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(3916)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(3916)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(3916)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(3916)/publications"},"_namespace":null},{"id":3917,"version":3,"created":1554881628000,"modified":1555035112000,"deprecated":false,"name":"Protein transport protein Sec24C","accession":"P53992","gene":"SEC24C","description":"Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9793936256307447,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.320914,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.85290296784214,"pubTatorScore":0.9412589815090792,"self":"https://pharos.nih.gov/idg/api/v1/targets(3917)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(3917)/properties"},"_links":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(3917)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3917)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3917)/publications"},"_namespace":null},{"id":3918,"version":2,"created":1554881633000,"modified":1554881636000,"deprecated":false,"name":"Transmembrane protein 115","accession":"Q12893","gene":"TMEM115","description":"May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7788576399433962,"antibodyCount":83,"monoclonalCount":22,"pubmedCount":null,"jensenScore":56.157134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.399059345763565,"pubTatorScore":1.46640856720018,"self":"https://pharos.nih.gov/idg/api/v1/targets(3918)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(3918)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(3918)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(3918)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3918)/publications"},"_namespace":null},{"id":3919,"version":3,"created":1554881636000,"modified":1555035113000,"deprecated":false,"name":"Interferon-related developmental regulator 2","accession":"Q12894","gene":"IFRD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2546807132198274,"antibodyCount":116,"monoclonalCount":18,"pubmedCount":null,"jensenScore":16.795829,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.60089920924486,"pubTatorScore":0.7160033436347992,"self":"https://pharos.nih.gov/idg/api/v1/targets(3919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(3919)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(3919)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3919)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(3919)/publications"},"_namespace":null},{"id":3920,"version":2,"created":1554881639000,"modified":1554881641000,"deprecated":false,"name":"N-formyl peptide receptor 3","accession":"P25089","gene":"FPR3","description":"Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.4161251376274295,"antibodyCount":247,"monoclonalCount":29,"pubmedCount":null,"jensenScore":24.357608,"patentCount":14115,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.08921055232913,"pubTatorScore":1.5217491324139651,"self":"https://pharos.nih.gov/idg/api/v1/targets(3920)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(3920)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(3920)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(3920)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(3920)/publications"},"_namespace":null},{"id":3921,"version":2,"created":1554881642000,"modified":1554881644000,"deprecated":false,"name":"Tripartite motif-containing protein 26","accession":"Q12899","gene":"TRIM26","description":"E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8483797593849051,"antibodyCount":107,"monoclonalCount":10,"pubmedCount":null,"jensenScore":7.422795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.79176857315377,"pubTatorScore":0.878220787177387,"self":"https://pharos.nih.gov/idg/api/v1/targets(3921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(3921)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(3921)/links"},"_synonyms":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(3921)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(3921)/publications"},"_namespace":null},{"id":3922,"version":3,"created":1554881645000,"modified":1555035114000,"deprecated":false,"name":"IST1 homolog","accession":"P53990","gene":"IST1","description":"ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4672136550534614,"antibodyCount":61,"monoclonalCount":11,"pubmedCount":null,"jensenScore":14.830151,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.478504544643148,"pubTatorScore":1.4228554890370864,"self":"https://pharos.nih.gov/idg/api/v1/targets(3922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(3922)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(3922)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(3922)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(3922)/publications"},"_namespace":null},{"id":3923,"version":2,"created":1554881649000,"modified":1554881651000,"deprecated":false,"name":"Probable C-mannosyltransferase DPY19L3","accession":"Q6ZPD9","gene":"DPY19L3","description":"Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.34406462662249077,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.146826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.24785561429243,"pubTatorScore":-0.23408345420171428,"self":"https://pharos.nih.gov/idg/api/v1/targets(3923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(3923)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(3923)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(3923)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(3923)/publications"},"_namespace":null},{"id":3924,"version":2,"created":1554881652000,"modified":1554881655000,"deprecated":false,"name":"Activated RNA polymerase II transcriptional coactivator p15","accession":"P53999","gene":"SUB1","description":"General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4522154523558424,"antibodyCount":173,"monoclonalCount":17,"pubmedCount":null,"jensenScore":272.994773,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.79541559055961,"pubTatorScore":2.189997838384194,"self":"https://pharos.nih.gov/idg/api/v1/targets(3924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(3924)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(3924)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3924)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(3924)/publications"},"_namespace":null},{"id":3925,"version":2,"created":1554881656000,"modified":1554881658000,"deprecated":false,"name":"Putative ubiquitin-conjugating enzyme E2Q2-like protein","accession":"H0YL09","gene":"UBE2Q2L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.428571,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.0930583607851787,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(3925)/properties"},"_links":{"count":632,"href":"https://pharos.nih.gov/idg/api/v1/targets(3925)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(3925)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3925)/publications"},"_namespace":null},{"id":3926,"version":2,"created":1554881658000,"modified":1554881660000,"deprecated":false,"name":"Seizure 6-like protein","accession":"Q9BYH1","gene":"SEZ6L","description":"May contribute to specialized endoplasmic reticulum functions in neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8629671067519772,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.896546,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.80979424448098,"pubTatorScore":0.9267067101142968,"self":"https://pharos.nih.gov/idg/api/v1/targets(3926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(3926)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(3926)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(3926)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3926)/publications"},"_namespace":null},{"id":3927,"version":4,"created":1554881661000,"modified":1555035116000,"deprecated":false,"name":"Testosterone 17-beta-dehydrogenase 3","accession":"P37058","gene":"HSD17B3","description":"Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.037810670989468,"antibodyCount":140,"monoclonalCount":5,"pubmedCount":null,"jensenScore":102.213657,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":28.627995646129257,"pubTatorScore":1.7864433825275077,"self":"https://pharos.nih.gov/idg/api/v1/targets(3927)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(3927)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(3927)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3927)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3927)/publications"},"_namespace":null},{"id":3928,"version":2,"created":1554881718000,"modified":1554881720000,"deprecated":false,"name":"Diacylglycerol O-acyltransferase 2-like protein 6","accession":"Q6ZPD8","gene":"DGAT2L6","description":"Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.7781512503836436,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.115385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.568757793269306,"pubTatorScore":1.1873192065739093,"self":"https://pharos.nih.gov/idg/api/v1/targets(3928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(3928)/properties"},"_links":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(3928)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(3928)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3928)/publications"},"_namespace":null},{"id":3929,"version":2,"created":1554881720000,"modified":1554881722000,"deprecated":false,"name":"Transmembrane protein 250","accession":"H0YL14","gene":"TMEM250","description":"(Microbial infection) Promotes human herpesvirus 1 (HHV-1) proliferation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3929)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(3929)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(3929)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3929)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3929)/publications"},"_namespace":null},{"id":3930,"version":2,"created":1554881723000,"modified":1554881725000,"deprecated":false,"name":"NF-kappa-B inhibitor zeta","accession":"Q9BYH8","gene":"NFKBIZ","description":"Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1415121295355766,"antibodyCount":111,"monoclonalCount":22,"pubmedCount":null,"jensenScore":143.150619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.207311557458745,"pubTatorScore":1.7860056975757221,"self":"https://pharos.nih.gov/idg/api/v1/targets(3930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(3930)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(3930)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3930)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3930)/publications"},"_namespace":null},{"id":3931,"version":3,"created":1554881726000,"modified":1555035118000,"deprecated":false,"name":"DNA mismatch repair protein Mlh1","accession":"P40692","gene":"MLH1","description":"Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.342829370817891,"antibodyCount":495,"monoclonalCount":193,"pubmedCount":null,"jensenScore":2352.575493,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":54.45244486667269,"pubTatorScore":3.295855785854828,"self":"https://pharos.nih.gov/idg/api/v1/targets(3931)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1340,"href":"https://pharos.nih.gov/idg/api/v1/targets(3931)/properties"},"_links":{"count":1897,"href":"https://pharos.nih.gov/idg/api/v1/targets(3931)/links"},"_synonyms":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(3931)/synonyms"},"_publications":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(3931)/publications"},"_namespace":null},{"id":3932,"version":2,"created":1554881738000,"modified":1554881741000,"deprecated":false,"name":"Thymosin beta-10","accession":"P63313","gene":"TMSB10","description":"Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1728181861475013,"antibodyCount":81,"monoclonalCount":6,"pubmedCount":null,"jensenScore":149.820513,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.75575627019474,"pubTatorScore":1.3290587124783735,"self":"https://pharos.nih.gov/idg/api/v1/targets(3932)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3932)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(3932)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3932)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3932)/publications"},"_namespace":null},{"id":3933,"version":3,"created":1554881742000,"modified":1555035123000,"deprecated":false,"name":"Myosin light chain kinase 3","accession":"Q32MK0","gene":"MYLK3","description":"Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.9727527591383984,"antibodyCount":210,"monoclonalCount":2,"pubmedCount":null,"jensenScore":93.020789,"patentCount":4695,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.13067614018759,"pubTatorScore":1.924650345879145,"self":"https://pharos.nih.gov/idg/api/v1/targets(3933)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(3933)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(3933)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(3933)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(3933)/publications"},"_namespace":null},{"id":3934,"version":3,"created":1554881746000,"modified":1555035125000,"deprecated":false,"name":"Troponin C, slow skeletal and cardiac muscles","accession":"P63316","gene":"TNNC1","description":"Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-1.1512676463776845,"antibodyCount":281,"monoclonalCount":189,"pubmedCount":null,"jensenScore":12.683334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":34.713523592441746,"pubTatorScore":2.215332329299418,"self":"https://pharos.nih.gov/idg/api/v1/targets(3934)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(3934)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(3934)/links"},"_synonyms":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(3934)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(3934)/publications"},"_namespace":null},{"id":3935,"version":2,"created":1554881751000,"modified":1554881751000,"deprecated":false,"name":"Putative uncharacterized protein C16orf47","accession":"Q6ZP98","gene":"C16orf47","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3935)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3935)/properties"},"_links":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3935)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(3935)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3935)/publications"},"_namespace":null},{"id":3936,"version":3,"created":1554881751000,"modified":1555035126000,"deprecated":false,"name":"Transferrin receptor protein 2","accession":"Q9UP52","gene":"TFR2","description":"Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1188231237951185,"antibodyCount":149,"monoclonalCount":41,"pubmedCount":null,"jensenScore":135.173015,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.148221735585885,"pubTatorScore":2.21111629711719,"self":"https://pharos.nih.gov/idg/api/v1/targets(3936)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(3936)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(3936)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3936)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3936)/publications"},"_namespace":null},{"id":3937,"version":3,"created":1554881755000,"modified":1555035127000,"deprecated":false,"name":"Hematopoietic lineage cell-specific protein","accession":"P14317","gene":"HCLS1","description":"Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1816394827638435,"antibodyCount":359,"monoclonalCount":71,"pubmedCount":null,"jensenScore":11.193991,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.79809044034828,"pubTatorScore":1.5510528273442687,"self":"https://pharos.nih.gov/idg/api/v1/targets(3937)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(3937)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(3937)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(3937)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(3937)/publications"},"_namespace":null},{"id":3938,"version":3,"created":1554881758000,"modified":1555035129000,"deprecated":false,"name":"Interferon regulatory factor 2","accession":"P14316","gene":"IRF2","description":"Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1531874040149215,"antibodyCount":378,"monoclonalCount":81,"pubmedCount":null,"jensenScore":132.657657,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":46.8557653740812,"pubTatorScore":1.986134784220777,"self":"https://pharos.nih.gov/idg/api/v1/targets(3938)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(3938)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(3938)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3938)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3938)/publications"},"_namespace":null},{"id":3939,"version":3,"created":1554881762000,"modified":1555035131000,"deprecated":false,"name":"Glucosidase 2 subunit beta","accession":"P14314","gene":"PRKCSH","description":"Regulatory subunit of glucosidase II.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.182554953949582,"antibodyCount":235,"monoclonalCount":15,"pubmedCount":null,"jensenScore":151.0297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":44.28474656988357,"pubTatorScore":1.6432411136810414,"self":"https://pharos.nih.gov/idg/api/v1/targets(3939)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(3939)/properties"},"_links":{"count":1167,"href":"https://pharos.nih.gov/idg/api/v1/targets(3939)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(3939)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(3939)/publications"},"_namespace":null},{"id":3940,"version":2,"created":1554881766000,"modified":1554881766000,"deprecated":false,"name":"Putative uncharacterized protein LOC100128554","accession":"Q0VFX4","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3940)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3940)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3940)/links"},"_synonyms":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3940)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3940)/publications"},"_namespace":null},{"id":3941,"version":3,"created":1554881766000,"modified":1555035132000,"deprecated":false,"name":"Mesoderm posterior protein 2","accession":"Q0VG99","gene":"MESP2","description":"Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4529081533260786,"antibodyCount":69,"monoclonalCount":46,"pubmedCount":null,"jensenScore":29.514941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":23.865461436432515,"pubTatorScore":1.179377234047986,"self":"https://pharos.nih.gov/idg/api/v1/targets(3941)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(3941)/properties"},"_links":{"count":696,"href":"https://pharos.nih.gov/idg/api/v1/targets(3941)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3941)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3941)/publications"},"_namespace":null},{"id":3942,"version":2,"created":1554881769000,"modified":1554881773000,"deprecated":false,"name":"Cytosolic phospholipase A2 gamma","accession":"Q9UP65","gene":"PLA2G4C","description":"Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.276904391552169,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":20.886618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.49458343259756,"pubTatorScore":1.389442190142018,"self":"https://pharos.nih.gov/idg/api/v1/targets(3942)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(3942)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(3942)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3942)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(3942)/publications"},"_namespace":null},{"id":3943,"version":2,"created":1554881774000,"modified":1554881777000,"deprecated":false,"name":"Y-box-binding protein 3","accession":"P16989","gene":"YBX3","description":"Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1316800814057566,"antibodyCount":204,"monoclonalCount":43,"pubmedCount":null,"jensenScore":143.058452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.77449463573702,"pubTatorScore":1.8248256883954732,"self":"https://pharos.nih.gov/idg/api/v1/targets(3943)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(3943)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(3943)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3943)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(3943)/publications"},"_namespace":null},{"id":3944,"version":4,"created":1554881778000,"modified":1555035133000,"deprecated":false,"name":"Farnesyl pyrophosphate synthase","accession":"P14324","gene":"FDPS","description":"Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.943228505161113,"antibodyCount":272,"monoclonalCount":20,"pubmedCount":null,"jensenScore":876.824683,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":46.90902955529074,"pubTatorScore":2.449798717847712,"self":"https://pharos.nih.gov/idg/api/v1/targets(3944)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(3944)/properties"},"_links":{"count":1404,"href":"https://pharos.nih.gov/idg/api/v1/targets(3944)/links"},"_synonyms":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(3944)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(3944)/publications"},"_namespace":null},{"id":3945,"version":3,"created":1554881841000,"modified":1555035135000,"deprecated":false,"name":"Calcium-binding mitochondrial carrier protein SCaMC-2","accession":"Q6KCM7","gene":"SLC25A25","description":"Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.4348010391362147,"antibodyCount":99,"monoclonalCount":7,"pubmedCount":null,"jensenScore":24.089166,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.399903627058045,"pubTatorScore":0.5826314394896365,"self":"https://pharos.nih.gov/idg/api/v1/targets(3945)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(3945)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(3945)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(3945)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3945)/publications"},"_namespace":null},{"id":3946,"version":2,"created":1554881844000,"modified":1554881848000,"deprecated":false,"name":"60S ribosomal protein L10","accession":"P27635","gene":"RPL10","description":"Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9491866298683272,"antibodyCount":191,"monoclonalCount":33,"pubmedCount":null,"jensenScore":8.098484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.78769280504803,"pubTatorScore":1.7376657420483432,"self":"https://pharos.nih.gov/idg/api/v1/targets(3946)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(3946)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(3946)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(3946)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(3946)/publications"},"_namespace":null},{"id":3947,"version":3,"created":1554881849000,"modified":1555035137000,"deprecated":false,"name":"Trans-Golgi network integral membrane protein 2","accession":"O43493","gene":"TGOLN2","description":"May be involved in regulating membrane traffic to and from trans-Golgi network.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.090064930811099,"antibodyCount":218,"monoclonalCount":21,"pubmedCount":null,"jensenScore":105.999096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":38.1158770185677,"pubTatorScore":1.955741170539587,"self":"https://pharos.nih.gov/idg/api/v1/targets(3947)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(3947)/properties"},"_links":{"count":1344,"href":"https://pharos.nih.gov/idg/api/v1/targets(3947)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(3947)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3947)/publications"},"_namespace":null},{"id":3948,"version":2,"created":1554881853000,"modified":1554881855000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 8","accession":"Q9UP79","gene":"ADAMTS8","description":"Has anti-angiogenic properties.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1448313893343802,"antibodyCount":153,"monoclonalCount":53,"pubmedCount":null,"jensenScore":14.538845,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.955273146858936,"pubTatorScore":1.1844430739466505,"self":"https://pharos.nih.gov/idg/api/v1/targets(3948)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(3948)/properties"},"_links":{"count":735,"href":"https://pharos.nih.gov/idg/api/v1/targets(3948)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3948)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3948)/publications"},"_namespace":null},{"id":3949,"version":3,"created":1554881856000,"modified":1554881944000,"deprecated":false,"name":"Voltage-dependent T-type calcium channel subunit alpha-1G","accession":"O43497","gene":"CACNA1G","description":"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the \"low-voltage activated (LVA)\" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.166682647410236,"antibodyCount":217,"monoclonalCount":93,"pubmedCount":null,"jensenScore":140.796581,"patentCount":6621,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.89637925978003,"pubTatorScore":2.1539644522667154,"self":"https://pharos.nih.gov/idg/api/v1/targets(3949)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(3949)/properties"},"_links":{"count":1280,"href":"https://pharos.nih.gov/idg/api/v1/targets(3949)/links"},"_synonyms":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(3949)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(3949)/publications"},"_namespace":null},{"id":3950,"version":3,"created":1554881946000,"modified":1555035138000,"deprecated":false,"name":"Zinc finger protein 250","accession":"P15622","gene":"ZNF250","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.44052745282500344,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.285218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":29.543580113347232,"pubTatorScore":-0.02940954079801761,"self":"https://pharos.nih.gov/idg/api/v1/targets(3950)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(3950)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(3950)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3950)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(3950)/publications"},"_namespace":null},{"id":3951,"version":3,"created":1554881948000,"modified":1555035139000,"deprecated":false,"name":"Zinc finger protein 44","accession":"P15621","gene":"ZNF44","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6215902878562718,"antibodyCount":90,"monoclonalCount":22,"pubmedCount":null,"jensenScore":37.129638,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.053695843174044,"pubTatorScore":0.6666030527574662,"self":"https://pharos.nih.gov/idg/api/v1/targets(3951)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(3951)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3951)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(3951)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(3951)/publications"},"_namespace":null},{"id":3952,"version":3,"created":1554881952000,"modified":1555035141000,"deprecated":false,"name":"Coiled-coil domain-containing protein 173","accession":"Q0VFZ6","gene":"CCDC173","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":20.643377863986963,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3952)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(3952)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(3952)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(3952)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3952)/publications"},"_namespace":null},{"id":3953,"version":3,"created":1554881954000,"modified":1555035142000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 53 homolog","accession":"Q5VIR6","gene":"VPS53","description":"Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8195439398848136,"antibodyCount":106,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.506473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.53842910086747,"pubTatorScore":0.6763249886483585,"self":"https://pharos.nih.gov/idg/api/v1/targets(3953)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(3953)/properties"},"_links":{"count":1192,"href":"https://pharos.nih.gov/idg/api/v1/targets(3953)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3953)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(3953)/publications"},"_namespace":null},{"id":3954,"version":2,"created":1554881958000,"modified":1554881959000,"deprecated":false,"name":"Putative uncharacterized protein C19orf81","accession":"C9J6K1","gene":"C19orf81","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3954)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(3954)/properties"},"_links":{"count":614,"href":"https://pharos.nih.gov/idg/api/v1/targets(3954)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(3954)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3954)/publications"},"_namespace":null},{"id":3955,"version":3,"created":1554881960000,"modified":1555035144000,"deprecated":false,"name":"Angiotensinogen","accession":"P01019","gene":"AGT","description":"Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.2459117071332457,"antibodyCount":695,"monoclonalCount":247,"pubmedCount":null,"jensenScore":1711.329142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":44.136841624299656,"pubTatorScore":4.0371392830973925,"self":"https://pharos.nih.gov/idg/api/v1/targets(3955)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1490,"href":"https://pharos.nih.gov/idg/api/v1/targets(3955)/properties"},"_links":{"count":1675,"href":"https://pharos.nih.gov/idg/api/v1/targets(3955)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(3955)/synonyms"},"_publications":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(3955)/publications"},"_namespace":null},{"id":3956,"version":3,"created":1554881972000,"modified":1555035149000,"deprecated":false,"name":"Conserved oligomeric Golgi complex subunit 5","accession":"Q9UP83","gene":"COG5","description":"Required for normal Golgi function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0030114349822905,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.406495,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":39.85182010617554,"pubTatorScore":1.0027433975358704,"self":"https://pharos.nih.gov/idg/api/v1/targets(3956)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(3956)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(3956)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(3956)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3956)/publications"},"_namespace":null},{"id":3957,"version":2,"created":1554881976000,"modified":1554881983000,"deprecated":false,"name":"Endoplasmic reticulum aminopeptidase 2","accession":"Q6P179","gene":"ERAP2","description":"Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.737642898917252,"antibodyCount":76,"monoclonalCount":4,"pubmedCount":null,"jensenScore":53.09635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.106922563437873,"pubTatorScore":1.7148844220091675,"self":"https://pharos.nih.gov/idg/api/v1/targets(3957)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(3957)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(3957)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(3957)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(3957)/publications"},"_namespace":null},{"id":3958,"version":2,"created":1554881984000,"modified":1554881988000,"deprecated":false,"name":"Alpha-1-antichymotrypsin","accession":"P01011","gene":"SERPINA3","description":"Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.947802568430972,"antibodyCount":276,"monoclonalCount":89,"pubmedCount":null,"jensenScore":812.651896,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.853726590596295,"pubTatorScore":2.9383199468013417,"self":"https://pharos.nih.gov/idg/api/v1/targets(3958)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":505,"href":"https://pharos.nih.gov/idg/api/v1/targets(3958)/properties"},"_links":{"count":1107,"href":"https://pharos.nih.gov/idg/api/v1/targets(3958)/links"},"_synonyms":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(3958)/synonyms"},"_publications":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(3958)/publications"},"_namespace":null},{"id":3959,"version":3,"created":1554881989000,"modified":1555035151000,"deprecated":false,"name":"Transmembrane protein 182","accession":"Q6ZP80","gene":"TMEM182","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.20164536254103646,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.836905,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":20.716497870176916,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(3959)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(3959)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(3959)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(3959)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3959)/publications"},"_namespace":null},{"id":3960,"version":2,"created":1554881991000,"modified":1554881992000,"deprecated":false,"name":"Putative golgin subfamily A member 6-like protein 19","accession":"H0YKK7","gene":"GOLGA6L19","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.5598397298267521,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3960)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(3960)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(3960)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3960)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(3960)/publications"},"_namespace":null},{"id":3961,"version":2,"created":1554881992000,"modified":1554881994000,"deprecated":false,"name":"Coiled-coil domain-containing protein 141","accession":"Q6ZP82","gene":"CCDC141","description":"Plays a critical role in radial migration and centrosomal function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6663520492272001,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.128126,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.018042623977543,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(3961)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(3961)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(3961)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3961)/publications"},"_namespace":null},{"id":3962,"version":2,"created":1554881994000,"modified":1554881997000,"deprecated":false,"name":"Pregnancy-specific beta-1-glycoprotein 4","accession":"Q00888","gene":"PSG4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8390356298722367,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.488282,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.879584970880153,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(3962)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(3962)/properties"},"_links":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(3962)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(3962)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(3962)/publications"},"_namespace":null},{"id":3963,"version":2,"created":1554881998000,"modified":1554881999000,"deprecated":false,"name":"Late cornified envelope protein 5A","accession":"Q5TCM9","gene":"LCE5A","description":"Precursors of the cornified envelope of the stratum corneum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.49939764986510915,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.316667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.696667824070243,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3963)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(3963)/properties"},"_links":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(3963)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(3963)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3963)/publications"},"_namespace":null},{"id":3964,"version":3,"created":1554881999000,"modified":1555035152000,"deprecated":false,"name":"Pregnancy-specific beta-1-glycoprotein 9","accession":"Q00887","gene":"PSG9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.617254278711766,"antibodyCount":170,"monoclonalCount":2,"pubmedCount":null,"jensenScore":40.321757,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":20.1386654884362,"pubTatorScore":1.2102165570275392,"self":"https://pharos.nih.gov/idg/api/v1/targets(3964)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(3964)/properties"},"_links":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(3964)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(3964)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(3964)/publications"},"_namespace":null},{"id":3965,"version":2,"created":1554882000000,"modified":1554882009000,"deprecated":false,"name":"Alpha-1-antitrypsin","accession":"P01009","gene":"SERPINA1","description":"Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.7491410454007053,"antibodyCount":1083,"monoclonalCount":457,"pubmedCount":null,"jensenScore":5601.818475,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.661491868069916,"pubTatorScore":3.369733740702316,"self":"https://pharos.nih.gov/idg/api/v1/targets(3965)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(3965)/properties"},"_links":{"count":1863,"href":"https://pharos.nih.gov/idg/api/v1/targets(3965)/links"},"_synonyms":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(3965)/synonyms"},"_publications":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(3965)/publications"},"_namespace":null},{"id":3966,"version":3,"created":1554882011000,"modified":1555035153000,"deprecated":false,"name":"Antithrombin-III","accession":"P01008","gene":"SERPINC1","description":"Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.984514501845545,"antibodyCount":580,"monoclonalCount":165,"pubmedCount":null,"jensenScore":9678.878306,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":36.45980321269274,"pubTatorScore":3.6202109636863646,"self":"https://pharos.nih.gov/idg/api/v1/targets(3966)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":600,"href":"https://pharos.nih.gov/idg/api/v1/targets(3966)/properties"},"_links":{"count":1140,"href":"https://pharos.nih.gov/idg/api/v1/targets(3966)/links"},"_synonyms":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(3966)/synonyms"},"_publications":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3966)/publications"},"_namespace":null},{"id":3967,"version":2,"created":1554882024000,"modified":1554882026000,"deprecated":false,"name":"Nuclear pore complex-interacting protein family member B5","accession":"A8MRT5","gene":"NPIPB5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.916237118405043,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3967)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(3967)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(3967)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(3967)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(3967)/publications"},"_namespace":null},{"id":3968,"version":2,"created":1554882027000,"modified":1554882028000,"deprecated":false,"name":"Pregnancy-specific beta-1-glycoprotein 6","accession":"Q00889","gene":"PSG6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9419929832652499,"antibodyCount":114,"monoclonalCount":27,"pubmedCount":null,"jensenScore":8.647086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.58095376042265,"pubTatorScore":0.983024532665017,"self":"https://pharos.nih.gov/idg/api/v1/targets(3968)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(3968)/properties"},"_links":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(3968)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3968)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(3968)/publications"},"_namespace":null},{"id":3969,"version":2,"created":1554882028000,"modified":1554882030000,"deprecated":false,"name":"Solute carrier family 12 member 4","accession":"Q9UP95","gene":"SLC12A4","description":"Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.7212084570814559,"antibodyCount":119,"monoclonalCount":9,"pubmedCount":null,"jensenScore":47.863852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.60771533295169,"pubTatorScore":1.5239063851619967,"self":"https://pharos.nih.gov/idg/api/v1/targets(3969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(3969)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(3969)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3969)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(3969)/publications"},"_namespace":null},{"id":3970,"version":2,"created":1554882031000,"modified":1554882036000,"deprecated":false,"name":"Krueppel-like factor 4","accession":"O43474","gene":"KLF4","description":"Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.894469378323507,"antibodyCount":686,"monoclonalCount":215,"pubmedCount":null,"jensenScore":774.082916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.73950013985303,"pubTatorScore":2.675236022936258,"self":"https://pharos.nih.gov/idg/api/v1/targets(3970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":709,"href":"https://pharos.nih.gov/idg/api/v1/targets(3970)/properties"},"_links":{"count":1304,"href":"https://pharos.nih.gov/idg/api/v1/targets(3970)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(3970)/synonyms"},"_publications":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(3970)/publications"},"_namespace":null},{"id":3971,"version":3,"created":1554882037000,"modified":1555035156000,"deprecated":false,"name":"Kininogen-1","accession":"P01042","gene":"KNG1","description":"(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-4.063787955679751,"antibodyCount":439,"monoclonalCount":74,"pubmedCount":null,"jensenScore":11365.403205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":40.26274524554544,"pubTatorScore":3.6887519685046435,"self":"https://pharos.nih.gov/idg/api/v1/targets(3971)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":541,"href":"https://pharos.nih.gov/idg/api/v1/targets(3971)/properties"},"_links":{"count":1154,"href":"https://pharos.nih.gov/idg/api/v1/targets(3971)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(3971)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(3971)/publications"},"_namespace":null},{"id":3972,"version":3,"created":1554882065000,"modified":1555035158000,"deprecated":false,"name":"Cystatin-A","accession":"P01040","gene":"CSTA","description":"This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.292527764092635,"antibodyCount":334,"monoclonalCount":58,"pubmedCount":null,"jensenScore":201.675428,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.90041122773633,"pubTatorScore":2.0068309358902643,"self":"https://pharos.nih.gov/idg/api/v1/targets(3972)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(3972)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(3972)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(3972)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3972)/publications"},"_namespace":null},{"id":3973,"version":3,"created":1554882069000,"modified":1555035160000,"deprecated":false,"name":"Alpha-(1,6)-fucosyltransferase","accession":"Q9BYC5","gene":"FUT8","description":"Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.937243956851341,"antibodyCount":145,"monoclonalCount":4,"pubmedCount":null,"jensenScore":92.911202,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":47.75646697192109,"pubTatorScore":1.8459120255791432,"self":"https://pharos.nih.gov/idg/api/v1/targets(3973)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(3973)/properties"},"_links":{"count":1163,"href":"https://pharos.nih.gov/idg/api/v1/targets(3973)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(3973)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(3973)/publications"},"_namespace":null},{"id":3974,"version":2,"created":1554882073000,"modified":1554882081000,"deprecated":false,"name":"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit","accession":"P39656","gene":"DDOST","description":"Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.603131413466192,"antibodyCount":140,"monoclonalCount":52,"pubmedCount":null,"jensenScore":44.059352,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.95544195975814,"pubTatorScore":2.3014752253873794,"self":"https://pharos.nih.gov/idg/api/v1/targets(3974)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(3974)/properties"},"_links":{"count":1187,"href":"https://pharos.nih.gov/idg/api/v1/targets(3974)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3974)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(3974)/publications"},"_namespace":null},{"id":3975,"version":2,"created":1554882082000,"modified":1554882084000,"deprecated":false,"name":"39S ribosomal protein L20, mitochondrial","accession":"Q9BYC9","gene":"MRPL20","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.2304489213782739,"antibodyCount":48,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.052632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.57746062686369,"pubTatorScore":-1.230445447036316,"self":"https://pharos.nih.gov/idg/api/v1/targets(3975)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(3975)/properties"},"_links":{"count":1070,"href":"https://pharos.nih.gov/idg/api/v1/targets(3975)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3975)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3975)/publications"},"_namespace":null},{"id":3976,"version":2,"created":1554882085000,"modified":1554882087000,"deprecated":false,"name":"39S ribosomal protein L32, mitochondrial","accession":"Q9BYC8","gene":"MRPL32","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":52,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.933824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.22483868579805,"pubTatorScore":0.057991892690873126,"self":"https://pharos.nih.gov/idg/api/v1/targets(3976)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(3976)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(3976)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(3976)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(3976)/publications"},"_namespace":null},{"id":3977,"version":3,"created":1554882088000,"modified":1555035161000,"deprecated":false,"name":"Myosin-binding protein C, slow-type","accession":"Q00872","gene":"MYBPC1","description":"Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2940855090071697,"antibodyCount":185,"monoclonalCount":43,"pubmedCount":null,"jensenScore":19.976689,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.16991105148905,"pubTatorScore":1.1884206105125008,"self":"https://pharos.nih.gov/idg/api/v1/targets(3977)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(3977)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(3977)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3977)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(3977)/publications"},"_namespace":null},{"id":3978,"version":2,"created":1554882093000,"modified":1554882095000,"deprecated":false,"name":"ETS domain-containing protein Elk-3","accession":"P41970","gene":"ELK3","description":"May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.17123875843274158,"antibodyCount":225,"monoclonalCount":66,"pubmedCount":null,"jensenScore":0.855556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.925087488697024,"pubTatorScore":2.2320132573576017,"self":"https://pharos.nih.gov/idg/api/v1/targets(3978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(3978)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(3978)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(3978)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(3978)/publications"},"_namespace":null},{"id":3979,"version":3,"created":1554882096000,"modified":1555035163000,"deprecated":false,"name":"Vascular endothelial growth factor A","accession":"P15692","gene":"VEGFA","description":"Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-4.271971045579481,"antibodyCount":1809,"monoclonalCount":609,"pubmedCount":null,"jensenScore":19076.63297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":61.85342441809978,"pubTatorScore":4.313556681621036,"self":"https://pharos.nih.gov/idg/api/v1/targets(3979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":4823,"href":"https://pharos.nih.gov/idg/api/v1/targets(3979)/properties"},"_links":{"count":5319,"href":"https://pharos.nih.gov/idg/api/v1/targets(3979)/links"},"_synonyms":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(3979)/synonyms"},"_publications":{"count":4080,"href":"https://pharos.nih.gov/idg/api/v1/targets(3979)/publications"},"_namespace":null},{"id":3980,"version":3,"created":1554882147000,"modified":1555035181000,"deprecated":false,"name":"Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial","accession":"Q9BYC2","gene":"OXCT2","description":"Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4771212590626073,"antibodyCount":62,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.609524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":21.867844133878332,"pubTatorScore":0.5006023962843915,"self":"https://pharos.nih.gov/idg/api/v1/targets(3980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(3980)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(3980)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(3980)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(3980)/publications"},"_namespace":null},{"id":3981,"version":3,"created":1554882150000,"modified":1555035182000,"deprecated":false,"name":"Cystatin-SN","accession":"P01037","gene":"CST1","description":"Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5071749603690217,"antibodyCount":130,"monoclonalCount":29,"pubmedCount":null,"jensenScore":33.009013,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":19.984929745645697,"pubTatorScore":1.6082403321683565,"self":"https://pharos.nih.gov/idg/api/v1/targets(3981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(3981)/properties"},"_links":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(3981)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(3981)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(3981)/publications"},"_namespace":null},{"id":3982,"version":2,"created":1554882151000,"modified":1554882152000,"deprecated":false,"name":"Cystatin-S","accession":"P01036","gene":"CST4","description":"This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8378378156984259,"antibodyCount":170,"monoclonalCount":71,"pubmedCount":null,"jensenScore":57.182857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.072268269034875,"pubTatorScore":1.591108769189144,"self":"https://pharos.nih.gov/idg/api/v1/targets(3982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(3982)/properties"},"_links":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(3982)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(3982)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(3982)/publications"},"_namespace":null},{"id":3983,"version":2,"created":1554882152000,"modified":1554882158000,"deprecated":false,"name":"Cystatin-C","accession":"P01034","gene":"CST3","description":"As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.52815110630235,"antibodyCount":866,"monoclonalCount":401,"pubmedCount":null,"jensenScore":3278.828059,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.13588396483835,"pubTatorScore":3.459973435966225,"self":"https://pharos.nih.gov/idg/api/v1/targets(3983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(3983)/properties"},"_links":{"count":1561,"href":"https://pharos.nih.gov/idg/api/v1/targets(3983)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(3983)/synonyms"},"_publications":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(3983)/publications"},"_namespace":null},{"id":3984,"version":3,"created":1554882160000,"modified":1555035184000,"deprecated":false,"name":"Metalloproteinase inhibitor 1","accession":"P01033","gene":"TIMP1","description":"Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.5724652059109565,"antibodyCount":810,"monoclonalCount":312,"pubmedCount":null,"jensenScore":3714.771226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.11008299443411,"pubTatorScore":3.356676601259898,"self":"https://pharos.nih.gov/idg/api/v1/targets(3984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(3984)/properties"},"_links":{"count":1679,"href":"https://pharos.nih.gov/idg/api/v1/targets(3984)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(3984)/synonyms"},"_publications":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(3984)/publications"},"_namespace":null},{"id":3985,"version":2,"created":1554882170000,"modified":1554882182000,"deprecated":false,"name":"Histamine H2 receptor","accession":"P25021","gene":"HRH2","description":"The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-3.212667069504858,"antibodyCount":244,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1595.148382,"patentCount":10472,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.69699619257497,"pubTatorScore":1.9185732325758167,"self":"https://pharos.nih.gov/idg/api/v1/targets(3985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(3985)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(3985)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(3985)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(3985)/publications"},"_namespace":null},{"id":3986,"version":3,"created":1554882183000,"modified":1555035187000,"deprecated":false,"name":"Complement C5","accession":"P01031","gene":"C5","description":"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.266903894741929,"antibodyCount":448,"monoclonalCount":160,"pubmedCount":null,"jensenScore":170.785601,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.17613233203636,"pubTatorScore":2.972587951603377,"self":"https://pharos.nih.gov/idg/api/v1/targets(3986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":532,"href":"https://pharos.nih.gov/idg/api/v1/targets(3986)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(3986)/links"},"_synonyms":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(3986)/synonyms"},"_publications":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(3986)/publications"},"_namespace":null},{"id":3987,"version":2,"created":1554882190000,"modified":1554882203000,"deprecated":false,"name":"C-X-C chemokine receptor type 1","accession":"P25024","gene":"CXCR1","description":"Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.4805145910368873,"antibodyCount":378,"monoclonalCount":165,"pubmedCount":null,"jensenScore":278.123008,"patentCount":40133,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.922061599950272,"pubTatorScore":2.437399038317895,"self":"https://pharos.nih.gov/idg/api/v1/targets(3987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(3987)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(3987)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(3987)/synonyms"},"_publications":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(3987)/publications"},"_namespace":null},{"id":3988,"version":3,"created":1554882205000,"modified":1555035189000,"deprecated":false,"name":"Protein Mis18-beta","accession":"O43482","gene":"OIP5","description":"Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2573737545910975,"antibodyCount":65,"monoclonalCount":17,"pubmedCount":null,"jensenScore":17.742897,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":31.204064878311844,"pubTatorScore":1.1009446061682393,"self":"https://pharos.nih.gov/idg/api/v1/targets(3988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(3988)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(3988)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(3988)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(3988)/publications"},"_namespace":null},{"id":3989,"version":2,"created":1554882208000,"modified":1554882211000,"deprecated":false,"name":"Aflatoxin B1 aldehyde reductase member 2","accession":"O43488","gene":"AKR7A2","description":"Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.57326920703272,"antibodyCount":197,"monoclonalCount":26,"pubmedCount":null,"jensenScore":369.550862,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.796832386851236,"pubTatorScore":2.0975969020977643,"self":"https://pharos.nih.gov/idg/api/v1/targets(3989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(3989)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(3989)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(3989)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(3989)/publications"},"_namespace":null},{"id":3990,"version":3,"created":1554882212000,"modified":1555035190000,"deprecated":false,"name":"Guanine nucleotide-binding protein subunit beta-like protein 1","accession":"Q9BYB4","gene":"GNB1L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8840511699536393,"antibodyCount":60,"monoclonalCount":2,"pubmedCount":null,"jensenScore":77.056347,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.61967589880275,"pubTatorScore":1.543240023784014,"self":"https://pharos.nih.gov/idg/api/v1/targets(3990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(3990)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(3990)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3990)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(3990)/publications"},"_namespace":null},{"id":3991,"version":3,"created":1554882215000,"modified":1555035192000,"deprecated":false,"name":"Adenylate kinase 9","accession":"Q5TCS8","gene":"AK9","description":"Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-0.9800230390546834,"antibodyCount":94,"monoclonalCount":7,"pubmedCount":null,"jensenScore":9.162933,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":28.563080872617213,"pubTatorScore":0.48902043106861287,"self":"https://pharos.nih.gov/idg/api/v1/targets(3991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(3991)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(3991)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(3991)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(3991)/publications"},"_namespace":null},{"id":3992,"version":3,"created":1554882219000,"modified":1555035193000,"deprecated":false,"name":"Zinc finger protein RFP","accession":"P14373","gene":"TRIM27","description":"E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.52798467671686,"antibodyCount":172,"monoclonalCount":19,"pubmedCount":null,"jensenScore":33.006204,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.8693499116394,"pubTatorScore":2.542372412018218,"self":"https://pharos.nih.gov/idg/api/v1/targets(3992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(3992)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(3992)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(3992)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(3992)/publications"},"_namespace":null},{"id":3993,"version":3,"created":1554882222000,"modified":1555035195000,"deprecated":false,"name":"SH3 and multiple ankyrin repeat domains protein 3","accession":"Q9BYB0","gene":"SHANK3","description":"Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2664769355761285,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":182.884613,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.27919227627427,"pubTatorScore":2.14067022896725,"self":"https://pharos.nih.gov/idg/api/v1/targets(3993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(3993)/properties"},"_links":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(3993)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(3993)/synonyms"},"_publications":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(3993)/publications"},"_namespace":null},{"id":3994,"version":2,"created":1554882224000,"modified":1554882226000,"deprecated":false,"name":"Zinc finger protein 468","accession":"Q5VIY5","gene":"ZNF468","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.0,"antibodyCount":28,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.50041520293347,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(3994)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(3994)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(3994)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(3994)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(3994)/publications"},"_namespace":null},{"id":3995,"version":2,"created":1554882227000,"modified":1554882251000,"deprecated":false,"name":"Melanocortin receptor 3","accession":"P41968","gene":"MC3R","description":"Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.6555566358516924,"antibodyCount":202,"monoclonalCount":18,"pubmedCount":null,"jensenScore":445.299698,"patentCount":48013,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.492506163342515,"pubTatorScore":2.3195259450491292,"self":"https://pharos.nih.gov/idg/api/v1/targets(3995)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(3995)/properties"},"_links":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(3995)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(3995)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(3995)/publications"},"_namespace":null},{"id":3996,"version":3,"created":1554882252000,"modified":1555035196000,"deprecated":false,"name":"Band 4.1-like protein 2","accession":"O43491","gene":"EPB41L2","description":"Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3675723704327165,"antibodyCount":173,"monoclonalCount":2,"pubmedCount":null,"jensenScore":26.475853,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":47.61830883673933,"pubTatorScore":1.499173266794928,"self":"https://pharos.nih.gov/idg/api/v1/targets(3996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(3996)/properties"},"_links":{"count":1230,"href":"https://pharos.nih.gov/idg/api/v1/targets(3996)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3996)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(3996)/publications"},"_namespace":null},{"id":3997,"version":2,"created":1554882257000,"modified":1554882263000,"deprecated":false,"name":"Prominin-1","accession":"O43490","gene":"PROM1","description":"May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3022912794081636,"antibodyCount":351,"monoclonalCount":135,"pubmedCount":null,"jensenScore":2035.033915,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.951659414870655,"pubTatorScore":3.1769970081508943,"self":"https://pharos.nih.gov/idg/api/v1/targets(3997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/properties"},"_links":{"count":1622,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/synonyms"},"_publications":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(3997)/publications"},"_namespace":null},{"id":3998,"version":3,"created":1554882265000,"modified":1555035198000,"deprecated":false,"name":"Complement C3","accession":"P01024","gene":"C3","description":"Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.5596262481836436,"antibodyCount":1079,"monoclonalCount":501,"pubmedCount":null,"jensenScore":3446.071636,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.88438700142456,"pubTatorScore":3.62253880942313,"self":"https://pharos.nih.gov/idg/api/v1/targets(3998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/properties"},"_links":{"count":1543,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/links"},"_synonyms":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/synonyms"},"_publications":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(3998)/publications"},"_namespace":null},{"id":3999,"version":3,"created":1554882275000,"modified":1555035201000,"deprecated":false,"name":"Alpha-2-macroglobulin","accession":"P01023","gene":"A2M","description":"Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9607326535296017,"antibodyCount":642,"monoclonalCount":138,"pubmedCount":null,"jensenScore":801.946106,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":45.894234851421494,"pubTatorScore":3.3914515801254885,"self":"https://pharos.nih.gov/idg/api/v1/targets(3999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/properties"},"_links":{"count":1177,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(3999)/publications"},"_namespace":null},{"id":4000,"version":2,"created":1554882281000,"modified":1554882306000,"deprecated":false,"name":"Maltase-glucoamylase, intestinal","accession":"O43451","gene":"MGAM","description":"May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-4.5215778122599195,"antibodyCount":32,"monoclonalCount":3,"pubmedCount":null,"jensenScore":32564.428262,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.05224102713403,"pubTatorScore":1.9135026801582784,"self":"https://pharos.nih.gov/idg/api/v1/targets(4000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(4000)/publications"},"_namespace":null}]}