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Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. 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Plays a role in apoptosis negative control involved in brain development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.774155934827549,"antibodyCount":131,"monoclonalCount":46,"pubmedCount":null,"jensenScore":57.879913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.08992188346387,"pubTatorScore":0.9956351945975499,"self":"https://pharos.nih.gov/idg/api/v1/targets(2428)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(2428)/publications"},"_namespace":null},{"id":2429,"version":3,"created":1554870990000,"modified":1555034013000,"deprecated":false,"name":"Zinc transporter ZIP12","accession":"Q504Y0","gene":"SLC39A12","description":"Acts as a zinc-influx transporter (Potential). 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Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.9823250888944565,"antibodyCount":132,"monoclonalCount":52,"pubmedCount":null,"jensenScore":8.048146,"patentCount":724,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.319076560311764,"pubTatorScore":1.1417855397800447,"self":"https://pharos.nih.gov/idg/api/v1/targets(2433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2433)/publications"},"_namespace":null},{"id":2434,"version":3,"created":1554871008000,"modified":1555034017000,"deprecated":false,"name":"Unconventional myosin-Va","accession":"Q9Y4I1","gene":"MYO5A","description":"Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. 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Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0487966765835433,"antibodyCount":151,"monoclonalCount":36,"pubmedCount":null,"jensenScore":11.573713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.08837429552159,"pubTatorScore":0.865630378263598,"self":"https://pharos.nih.gov/idg/api/v1/targets(2443)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2443)/publications"},"_namespace":null},{"id":2444,"version":2,"created":1554871042000,"modified":1554871045000,"deprecated":false,"name":"RNA-binding protein 14","accession":"Q96PK6","gene":"RBM14","description":"Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. 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E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2500131487013686,"antibodyCount":38,"monoclonalCount":1,"pubmedCount":null,"jensenScore":18.440524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":46.99606687633982,"pubTatorScore":1.6928114166747799,"self":"https://pharos.nih.gov/idg/api/v1/targets(2492)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":522,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/properties"},"_links":{"count":1235,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/links"},"_synonyms":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(2492)/publications"},"_namespace":null},{"id":2493,"version":2,"created":1554871227000,"modified":1554871230000,"deprecated":false,"name":"LIM and SH3 domain protein 1","accession":"Q14847","gene":"LASP1","description":"Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. 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Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.467022799778345,"antibodyCount":245,"monoclonalCount":41,"pubmedCount":null,"jensenScore":275.1831,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.99153408830063,"pubTatorScore":2.203661975849583,"self":"https://pharos.nih.gov/idg/api/v1/targets(2495)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(2495)/publications"},"_namespace":null},{"id":2496,"version":3,"created":1554871249000,"modified":1555034063000,"deprecated":false,"name":"Phakinin","accession":"Q13515","gene":"BFSP2","description":"Involved in stabilization of lens fiber cell cytoskeleton.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5155691801039266,"antibodyCount":81,"monoclonalCount":37,"pubmedCount":null,"jensenScore":325.746497,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":24.284444600173497,"pubTatorScore":2.1573819886988583,"self":"https://pharos.nih.gov/idg/api/v1/targets(2496)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/properties"},"_links":{"count":501,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(2496)/publications"},"_namespace":null},{"id":2497,"version":2,"created":1554871251000,"modified":1554871254000,"deprecated":false,"name":"Protein BTG2","accession":"P78543","gene":"BTG2","description":"Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1037571583977814,"antibodyCount":209,"monoclonalCount":59,"pubmedCount":null,"jensenScore":142.735994,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.54098411069079,"pubTatorScore":2.1753232573209313,"self":"https://pharos.nih.gov/idg/api/v1/targets(2497)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/synonyms"},"_publications":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(2497)/publications"},"_namespace":null},{"id":2498,"version":3,"created":1554871254000,"modified":1555034067000,"deprecated":false,"name":"Lymphocyte antigen 86","accession":"O95711","gene":"LY86","description":"May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7184212649762483,"antibodyCount":272,"monoclonalCount":50,"pubmedCount":null,"jensenScore":481.625765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":61,"knowledgeAvailability":33.033621999557575,"pubTatorScore":0.9089338795053078,"self":"https://pharos.nih.gov/idg/api/v1/targets(2498)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2498)/publications"},"_namespace":null},{"id":2499,"version":2,"created":1554871257000,"modified":1554871259000,"deprecated":false,"name":"Exocyst complex component 3-like protein","accession":"Q86VI1","gene":"EXOC3L1","description":"As part of the exocyst, may play a role in regulated exocytosis of insulin granules.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.10145763913017275,"antibodyCount":62,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.304386,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.391136320166208,"pubTatorScore":-0.10914490371976707,"self":"https://pharos.nih.gov/idg/api/v1/targets(2499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(2499)/publications"},"_namespace":null},{"id":2500,"version":3,"created":1554871260000,"modified":1555034068000,"deprecated":false,"name":"Prepronociceptin","accession":"Q13519","gene":"PNOC","description":"Orphanin FQ2: Has potent analgesic activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7808400220371294,"antibodyCount":207,"monoclonalCount":4,"pubmedCount":null,"jensenScore":685.704777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":25.104380394746673,"pubTatorScore":2.57556283949513,"self":"https://pharos.nih.gov/idg/api/v1/targets(2500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/properties"},"_links":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/synonyms"},"_publications":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(2500)/publications"},"_namespace":null},{"id":2501,"version":2,"created":1554871263000,"modified":1554871264000,"deprecated":false,"name":"Achaete-scute homolog 4","accession":"Q6XD76","gene":"ASCL4","description":"Could be a transcriptional regulator involved in skin development.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.3108281295445815,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.972757,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.80377682033055,"pubTatorScore":0.4419568899810447,"self":"https://pharos.nih.gov/idg/api/v1/targets(2501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/properties"},"_links":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(2501)/publications"},"_namespace":null},{"id":2502,"version":3,"created":1554871264000,"modified":1555034070000,"deprecated":false,"name":"StAR-related lipid transfer protein 3","accession":"Q14849","gene":"STARD3","description":"Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.617213982292178,"antibodyCount":37,"monoclonalCount":7,"pubmedCount":null,"jensenScore":39.37065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.53697748631886,"pubTatorScore":1.6500154469127115,"self":"https://pharos.nih.gov/idg/api/v1/targets(2502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(2502)/publications"},"_namespace":null},{"id":2503,"version":2,"created":1554871268000,"modified":1554871271000,"deprecated":false,"name":"Endonuclease III-like protein 1","accession":"P78549","gene":"NTHL1","description":"Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8506629354298685,"antibodyCount":155,"monoclonalCount":12,"pubmedCount":null,"jensenScore":66.754211,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.54842941786516,"pubTatorScore":1.7861833171452188,"self":"https://pharos.nih.gov/idg/api/v1/targets(2503)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(2503)/publications"},"_namespace":null},{"id":2504,"version":2,"created":1554871272000,"modified":1554871274000,"deprecated":false,"name":"Tubulin polyglutamylase TTLL5","accession":"Q6EMB2","gene":"TTLL5","description":"Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6704814706607193,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.780199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.46869337903896,"pubTatorScore":1.5043081652917765,"self":"https://pharos.nih.gov/idg/api/v1/targets(2504)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(2504)/publications"},"_namespace":null},{"id":2505,"version":2,"created":1554871275000,"modified":1554871277000,"deprecated":false,"name":"Carbohydrate sulfotransferase 2","accession":"Q9Y4C5","gene":"CHST2","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2944332996364818,"antibodyCount":188,"monoclonalCount":1,"pubmedCount":null,"jensenScore":20.943641,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.9424969737328,"pubTatorScore":1.2654096886225348,"self":"https://pharos.nih.gov/idg/api/v1/targets(2505)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2505)/publications"},"_namespace":null},{"id":2506,"version":3,"created":1554871278000,"modified":1555034071000,"deprecated":false,"name":"Nucleolar protein 10","accession":"Q9BSC4","gene":"NOL10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.32585357963028805,"antibodyCount":59,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.369935,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":33.88292597402678,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(2506)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(2506)/publications"},"_namespace":null},{"id":2507,"version":2,"created":1554871280000,"modified":1554871282000,"deprecated":false,"name":"Malignant fibrous histiocytoma-amplified sequence 1","accession":"Q9Y4C4","gene":"MFHAS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7596332686251291,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.87136,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.30329064476425,"pubTatorScore":0.9439749912626114,"self":"https://pharos.nih.gov/idg/api/v1/targets(2507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(2507)/publications"},"_namespace":null},{"id":2508,"version":2,"created":1554871283000,"modified":1554871287000,"deprecated":false,"name":"Lysine-specific demethylase 3A","accession":"Q9Y4C1","gene":"KDM3A","description":"Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. 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Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.8354419439388556,"antibodyCount":253,"monoclonalCount":62,"pubmedCount":null,"jensenScore":74.687607,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.532143408688576,"pubTatorScore":1.6578531892034718,"self":"https://pharos.nih.gov/idg/api/v1/targets(2508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(2508)/publications"},"_namespace":null},{"id":2509,"version":3,"created":1554871288000,"modified":1555034073000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 35","accession":"A5YM69","gene":"ARHGEF35","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":9.64640156761473,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(2509)/publications"},"_namespace":null},{"id":2510,"version":3,"created":1554871290000,"modified":1555034074000,"deprecated":false,"name":"RWD domain-containing protein 2A","accession":"Q9UIY3","gene":"RWDD2A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0,"antibodyCount":43,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.712415380506815,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(2510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(2510)/publications"},"_namespace":null},{"id":2511,"version":2,"created":1554871293000,"modified":1554871296000,"deprecated":false,"name":"Neurexin-3","accession":"Q9Y4C0","gene":"NRXN3","description":"Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. 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Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. 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Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.80362205726688,"antibodyCount":376,"monoclonalCount":60,"pubmedCount":null,"jensenScore":549.597526,"patentCount":14037,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.36888076972349,"pubTatorScore":2.991556373265763,"self":"https://pharos.nih.gov/idg/api/v1/targets(2572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/properties"},"_links":{"count":1452,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/synonyms"},"_publications":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(2572)/publications"},"_namespace":null},{"id":2573,"version":2,"created":1554872366000,"modified":1554872368000,"deprecated":false,"name":"Endosomal/lysosomal potassium channel TMEM175","accession":"Q9BSA9","gene":"TMEM175","description":"Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. 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Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, SDCCAG3, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC complex subunits COMMD1, CCDC93 AND C16orf62 (PubMed:25355947). Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells (PubMed:18550675).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8363403373428943,"antibodyCount":45,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.5228787018508873,"self":"https://pharos.nih.gov/idg/api/v1/targets(2574)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(2574)/publications"},"_namespace":null},{"id":2575,"version":3,"created":1554872372000,"modified":1555034126000,"deprecated":false,"name":"Protein PML","accession":"P29590","gene":"PML","description":"Exhibits antiviral activity against both DNA and RNA viruses. 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Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6378531775694998,"antibodyCount":470,"monoclonalCount":99,"pubmedCount":null,"jensenScore":373.760337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":59.0043961457506,"pubTatorScore":3.102834436984397,"self":"https://pharos.nih.gov/idg/api/v1/targets(2575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/properties"},"_links":{"count":1698,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/synonyms"},"_publications":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(2575)/publications"},"_namespace":null},{"id":2576,"version":2,"created":1554872380000,"modified":1554872382000,"deprecated":false,"name":"Transmembrane protein 170A","accession":"Q8WVE7","gene":"TMEM170A","description":"Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. 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Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.107250385235662,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.544913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.59485324218395,"pubTatorScore":1.2265999052073575,"self":"https://pharos.nih.gov/idg/api/v1/targets(2595)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(2595)/publications"},"_namespace":null},{"id":2596,"version":2,"created":1554872456000,"modified":1554872459000,"deprecated":false,"name":"Protein phosphatase inhibitor 2","accession":"P41236","gene":"PPP1R2","description":"Inhibitor of protein-phosphatase 1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2052289524868685,"antibodyCount":259,"monoclonalCount":42,"pubmedCount":null,"jensenScore":26.245125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.80096174653072,"pubTatorScore":1.8056402449962383,"self":"https://pharos.nih.gov/idg/api/v1/targets(2596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(2596)/publications"},"_namespace":null},{"id":2597,"version":3,"created":1554872460000,"modified":1555034144000,"deprecated":false,"name":"Epidermal growth factor receptor substrate 15","accession":"P42566","gene":"EPS15","description":"Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2837378271827937,"antibodyCount":164,"monoclonalCount":7,"pubmedCount":null,"jensenScore":174.50817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.03869342642265,"pubTatorScore":2.0430947173808693,"self":"https://pharos.nih.gov/idg/api/v1/targets(2597)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(2597)/publications"},"_namespace":null},{"id":2598,"version":3,"created":1554872465000,"modified":1555034146000,"deprecated":false,"name":"Elongation factor Ts, mitochondrial","accession":"P43897","gene":"TSFM","description":"Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.307627275475032,"antibodyCount":123,"monoclonalCount":13,"pubmedCount":null,"jensenScore":199.39731,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":39.20422023574458,"pubTatorScore":1.6100846397757098,"self":"https://pharos.nih.gov/idg/api/v1/targets(2598)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(2598)/publications"},"_namespace":null},{"id":2599,"version":2,"created":1554872469000,"modified":1554872472000,"deprecated":false,"name":"C-C motif chemokine 20","accession":"P78556","gene":"CCL20","description":"Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1028349358622296,"antibodyCount":496,"monoclonalCount":242,"pubmedCount":null,"jensenScore":1250.330168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.023024280653996,"pubTatorScore":2.5749421541937734,"self":"https://pharos.nih.gov/idg/api/v1/targets(2599)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/synonyms"},"_publications":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(2599)/publications"},"_namespace":null},{"id":2600,"version":2,"created":1554872473000,"modified":1554872475000,"deprecated":false,"name":"RING finger protein 141","accession":"Q8WVD5","gene":"RNF141","description":"May be involved in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5298793068682367,"antibodyCount":159,"monoclonalCount":24,"pubmedCount":null,"jensenScore":3.397223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.91658066894902,"pubTatorScore":0.22902722033015813,"self":"https://pharos.nih.gov/idg/api/v1/targets(2600)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(2600)/publications"},"_namespace":null},{"id":2601,"version":2,"created":1554872476000,"modified":1554872478000,"deprecated":false,"name":"Copine-6","accession":"O95741","gene":"CPNE6","description":"Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7974026325913544,"antibodyCount":129,"monoclonalCount":30,"pubmedCount":null,"jensenScore":6.426953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.487965957138496,"pubTatorScore":0.5492076022531295,"self":"https://pharos.nih.gov/idg/api/v1/targets(2601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(2601)/publications"},"_namespace":null},{"id":2602,"version":2,"created":1554872479000,"modified":1554872481000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF138","accession":"Q8WVD3","gene":"RNF138","description":"E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0899624490445448,"antibodyCount":148,"monoclonalCount":6,"pubmedCount":null,"jensenScore":12.527552,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.03165499812923,"pubTatorScore":0.8774672947669043,"self":"https://pharos.nih.gov/idg/api/v1/targets(2602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2602)/publications"},"_namespace":null},{"id":2603,"version":2,"created":1554872482000,"modified":1554872484000,"deprecated":false,"name":"Eukaryotic translation initiation factor 4E-binding protein 2","accession":"Q13542","gene":"EIF4EBP2","description":"Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5577644138317688,"antibodyCount":189,"monoclonalCount":12,"pubmedCount":null,"jensenScore":33.404476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.54326994927551,"pubTatorScore":1.3137375451344497,"self":"https://pharos.nih.gov/idg/api/v1/targets(2603)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(2603)/publications"},"_namespace":null},{"id":2604,"version":2,"created":1554872485000,"modified":1554872488000,"deprecated":false,"name":"Serine/threonine-protein kinase OSR1","accession":"O95747","gene":"OXSR1","description":"Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-0.9983612454189109,"antibodyCount":355,"monoclonalCount":165,"pubmedCount":null,"jensenScore":9.443281,"patentCount":3270,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.81185477344251,"pubTatorScore":0.8664983490238036,"self":"https://pharos.nih.gov/idg/api/v1/targets(2604)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(2604)/publications"},"_namespace":null},{"id":2605,"version":3,"created":1554872488000,"modified":1555034149000,"deprecated":false,"name":"Interleukin-13 receptor subunit alpha-1","accession":"P78552","gene":"IL13RA1","description":"Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4520501357913467,"antibodyCount":375,"monoclonalCount":101,"pubmedCount":null,"jensenScore":22.993724,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.68501576742811,"pubTatorScore":1.7444792907008082,"self":"https://pharos.nih.gov/idg/api/v1/targets(2605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(2605)/publications"},"_namespace":null},{"id":2606,"version":4,"created":1554872492000,"modified":1555034153000,"deprecated":false,"name":"Histone deacetylase 1","accession":"Q13547","gene":"HDAC1","description":"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-3.0377538187205158,"antibodyCount":1201,"monoclonalCount":217,"pubmedCount":null,"jensenScore":954.3175,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":76,"knowledgeAvailability":60.71544157786779,"pubTatorScore":2.8702212319894196,"self":"https://pharos.nih.gov/idg/api/v1/targets(2606)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/properties"},"_links":{"count":3828,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/synonyms"},"_publications":{"count":552,"href":"https://pharos.nih.gov/idg/api/v1/targets(2606)/publications"},"_namespace":null},{"id":2607,"version":3,"created":1554873360000,"modified":1555034162000,"deprecated":false,"name":"Receptor-interacting serine/threonine-protein kinase 1","accession":"Q13546","gene":"RIPK1","description":"Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.339913726644165,"antibodyCount":375,"monoclonalCount":124,"pubmedCount":null,"jensenScore":211.835873,"patentCount":20387,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":47.93933928895063,"pubTatorScore":2.68297454645779,"self":"https://pharos.nih.gov/idg/api/v1/targets(2607)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/properties"},"_links":{"count":1248,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/synonyms"},"_publications":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(2607)/publications"},"_namespace":null},{"id":2608,"version":2,"created":1554873377000,"modified":1554873377000,"deprecated":false,"name":"Putative postmeiotic segregation increased 2-like protein 2","accession":"O95744","gene":"PMS2P2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.521999426090169,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2608)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(2608)/publications"},"_namespace":null},{"id":2609,"version":2,"created":1554873377000,"modified":1554873379000,"deprecated":false,"name":"FERM, ARHGEF and pleckstrin domain-containing protein 1","accession":"Q9Y4F1","gene":"FARP1","description":"Functions as guanine nucleotide exchange factor for RAC1. 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Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). 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Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. 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Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. 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Probably not involved in absorption of dietary fat in the small intestine (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0745992533913342,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.151445,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.094176674998835,"pubTatorScore":1.7214586693922311,"self":"https://pharos.nih.gov/idg/api/v1/targets(2669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/properties"},"_links":{"count":598,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2669)/publications"},"_namespace":null},{"id":2670,"version":3,"created":1554873624000,"modified":1555034206000,"deprecated":false,"name":"Myosin-binding protein C, cardiac-type","accession":"Q14896","gene":"MYBPC3","description":"Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. 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Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. 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Also has ManNAc kinase activity.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.6389447079658863,"antibodyCount":210,"monoclonalCount":38,"pubmedCount":null,"jensenScore":41.939264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":38.026242265961976,"pubTatorScore":1.261262844995535,"self":"https://pharos.nih.gov/idg/api/v1/targets(2686)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(2686)/publications"},"_namespace":null},{"id":2687,"version":2,"created":1554873682000,"modified":1554873682000,"deprecated":false,"name":"Insulin, isoform 2","accession":"F8WCM5","gene":"INS-IGF2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9462146549001682,"antibodyCount":72,"monoclonalCount":58,"pubmedCount":null,"jensenScore":7.722942,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.40638361293695,"pubTatorScore":0.22184857589852885,"self":"https://pharos.nih.gov/idg/api/v1/targets(2687)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/properties"},"_links":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(2687)/publications"},"_namespace":null},{"id":2688,"version":3,"created":1554873682000,"modified":1555034222000,"deprecated":false,"name":"NudC domain-containing protein 2","accession":"Q8WVJ2","gene":"NUDCD2","description":"May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.3010299956639813,"antibodyCount":54,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.882462413401228,"pubTatorScore":-0.1389497358344748,"self":"https://pharos.nih.gov/idg/api/v1/targets(2688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(2688)/publications"},"_namespace":null},{"id":2689,"version":2,"created":1554873685000,"modified":1554873688000,"deprecated":false,"name":"Small membrane A-kinase anchor protein","accession":"Q9BSF0","gene":"C2orf88","description":"Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.35954361767421344,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.189394,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.45920968369704335,"self":"https://pharos.nih.gov/idg/api/v1/targets(2689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(2689)/publications"},"_namespace":null},{"id":2690,"version":2,"created":1554873688000,"modified":1554873691000,"deprecated":false,"name":"Unconventional myosin-X","accession":"Q9HD67","gene":"MYO10","description":"Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4985540180189592,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":36.44972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.48244883158517,"pubTatorScore":1.7267883970529034,"self":"https://pharos.nih.gov/idg/api/v1/targets(2690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(2690)/publications"},"_namespace":null},{"id":2691,"version":3,"created":1554873692000,"modified":1555034223000,"deprecated":false,"name":"Sigma intracellular receptor 2","accession":"Q5BJF2","gene":"TMEM97","description":"Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.2750095257655023,"antibodyCount":67,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.794309,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.25173780648409,"pubTatorScore":1.205925792529446,"self":"https://pharos.nih.gov/idg/api/v1/targets(2691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2691)/publications"},"_namespace":null},{"id":2692,"version":3,"created":1554873697000,"modified":1555034224000,"deprecated":false,"name":"Breast cancer metastasis-suppressor 1","accession":"Q9HCU9","gene":"BRMS1","description":"Transcriptional repressor. 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May be a mediator of metastasis suppression in breast carcinoma.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6884737265046157,"antibodyCount":205,"monoclonalCount":40,"pubmedCount":null,"jensenScore":54.938129,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.560832473597145,"pubTatorScore":2.0325629516326655,"self":"https://pharos.nih.gov/idg/api/v1/targets(2692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/properties"},"_links":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2692)/publications"},"_namespace":null},{"id":2693,"version":2,"created":1554873701000,"modified":1554873703000,"deprecated":false,"name":"DNA polymerase delta subunit 4","accession":"Q9HCU8","gene":"POLD4","description":"As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8488730486596557,"antibodyCount":24,"monoclonalCount":14,"pubmedCount":null,"jensenScore":7.321211,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.75395753941333,"pubTatorScore":1.1031110676340896,"self":"https://pharos.nih.gov/idg/api/v1/targets(2693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2693)/publications"},"_namespace":null},{"id":2694,"version":2,"created":1554873704000,"modified":1554873705000,"deprecated":false,"name":"Annexin A10","accession":"Q9UJ72","gene":"ANXA10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3303983639857597,"antibodyCount":301,"monoclonalCount":54,"pubmedCount":null,"jensenScore":25.325146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.9264127108065,"pubTatorScore":1.4033458495313378,"self":"https://pharos.nih.gov/idg/api/v1/targets(2694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/properties"},"_links":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(2694)/publications"},"_namespace":null},{"id":2695,"version":2,"created":1554873705000,"modified":1554873707000,"deprecated":false,"name":"Mitochondrial import inner membrane translocase subunit Tim29","accession":"Q9BSF4","gene":"TIMM29","description":"Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. 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May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.3010299956639812,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(2695)/publications"},"_namespace":null},{"id":2696,"version":3,"created":1554873708000,"modified":1555034227000,"deprecated":false,"name":"Diacylglycerol kinase zeta","accession":"Q13574","gene":"DGKZ","description":"Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. 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Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.596876217336367,"antibodyCount":88,"monoclonalCount":6,"pubmedCount":null,"jensenScore":46.12173,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":45.877409277288905,"pubTatorScore":2.7909957069452913,"self":"https://pharos.nih.gov/idg/api/v1/targets(2699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":519,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/properties"},"_links":{"count":1170,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(2699)/publications"},"_namespace":null},{"id":2700,"version":3,"created":1554873721000,"modified":1555034234000,"deprecated":false,"name":"Inositol-tetrakisphosphate 1-kinase","accession":"Q13572","gene":"ITPK1","description":"Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.3843373297312092,"antibodyCount":201,"monoclonalCount":25,"pubmedCount":null,"jensenScore":24.778354,"patentCount":806,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.72310406626417,"pubTatorScore":1.2462757384430123,"self":"https://pharos.nih.gov/idg/api/v1/targets(2700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(2700)/publications"},"_namespace":null},{"id":2701,"version":3,"created":1554873724000,"modified":1555034237000,"deprecated":false,"name":"Outer dense fiber protein 2","accession":"Q5BJF6","gene":"ODF2","description":"Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. 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Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.8597308531956394,"antibodyCount":1160,"monoclonalCount":323,"pubmedCount":null,"jensenScore":723.440375,"patentCount":17380,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.30686744802299,"pubTatorScore":2.967767120295719,"self":"https://pharos.nih.gov/idg/api/v1/targets(2720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/properties"},"_links":{"count":1553,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/synonyms"},"_publications":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(2720)/publications"},"_namespace":null},{"id":2721,"version":2,"created":1554873836000,"modified":1554873836000,"deprecated":false,"name":"Putative uncharacterized protein FBXL19-AS1","accession":"Q494R0","gene":"FBXL19-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.741547609625183,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2721)/publications"},"_namespace":null},{"id":2722,"version":3,"created":1554873837000,"modified":1555034252000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase 8","accession":"P41279","gene":"MAP3K8","description":"Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.092296341326843,"antibodyCount":433,"monoclonalCount":21,"pubmedCount":null,"jensenScore":154.28257,"patentCount":54861,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.00266647402203,"pubTatorScore":2.012010857845673,"self":"https://pharos.nih.gov/idg/api/v1/targets(2722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":571,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/synonyms"},"_publications":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(2722)/publications"},"_namespace":null},{"id":2723,"version":2,"created":1554873857000,"modified":1554873859000,"deprecated":false,"name":"NADH-cytochrome b5 reductase 2","accession":"Q6BCY4","gene":"CYB5R2","description":"NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). 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Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6246016152220577,"antibodyCount":162,"monoclonalCount":10,"pubmedCount":null,"jensenScore":39.040329,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.410089364034754,"pubTatorScore":1.7233205435616321,"self":"https://pharos.nih.gov/idg/api/v1/targets(2726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/properties"},"_links":{"count":1117,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(2726)/publications"},"_namespace":null},{"id":2727,"version":2,"created":1554873869000,"modified":1554873871000,"deprecated":false,"name":"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein","accession":"Q9BSE4","gene":"HERPUD2","description":"Could be involved in the unfolded protein response (UPR) pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.195949938201696,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(2727)/publications"},"_namespace":null},{"id":2728,"version":2,"created":1554873871000,"modified":1554873873000,"deprecated":false,"name":"EF-hand calcium-binding domain-containing protein 10","accession":"A6NFE3","gene":"EFCAB10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.599378129394475,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/properties"},"_links":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(2728)/publications"},"_namespace":null},{"id":2729,"version":3,"created":1554873873000,"modified":1555034256000,"deprecated":false,"name":"Plexin-A1","accession":"Q9UIW2","gene":"PLXNA1","description":"Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.90927403612285,"antibodyCount":116,"monoclonalCount":28,"pubmedCount":null,"jensenScore":78.949715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.35977155294747,"pubTatorScore":1.4919024599298034,"self":"https://pharos.nih.gov/idg/api/v1/targets(2729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(2729)/publications"},"_namespace":null},{"id":2730,"version":3,"created":1554873877000,"modified":1555034258000,"deprecated":false,"name":"Ventral anterior homeobox 2","accession":"Q9UIW0","gene":"VAX2","description":"Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). 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The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. 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AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. 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Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.8029649220889077,"antibodyCount":204,"monoclonalCount":47,"pubmedCount":null,"jensenScore":657.033691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":35.04374980891447,"pubTatorScore":3.0552040479822944,"self":"https://pharos.nih.gov/idg/api/v1/targets(2758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/properties"},"_links":{"count":1137,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(2758)/publications"},"_namespace":null},{"id":2759,"version":2,"created":1554873995000,"modified":1554873998000,"deprecated":false,"name":"Zinc finger protein 682","accession":"O95780","gene":"ZNF682","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":132,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.93439505283389,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2759)/publications"},"_namespace":null},{"id":2760,"version":3,"created":1554873998000,"modified":1555034285000,"deprecated":false,"name":"Helicase ARIP4","accession":"Q9Y4B4","gene":"RAD54L2","description":"DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. 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Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5934267803798767,"antibodyCount":285,"monoclonalCount":47,"pubmedCount":null,"jensenScore":43.704649,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":43.24995194564011,"pubTatorScore":1.6452261833806812,"self":"https://pharos.nih.gov/idg/api/v1/targets(2778)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/properties"},"_links":{"count":1239,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(2778)/publications"},"_namespace":null},{"id":2779,"version":3,"created":1554874053000,"modified":1555034302000,"deprecated":false,"name":"Transformer-2 protein homolog alpha","accession":"Q13595","gene":"TRA2A","description":"Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0559187915810377,"antibodyCount":139,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.337283,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":70,"knowledgeAvailability":37.40889090225303,"pubTatorScore":0.5585942232596517,"self":"https://pharos.nih.gov/idg/api/v1/targets(2779)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(2779)/publications"},"_namespace":null},{"id":2780,"version":2,"created":1554874056000,"modified":1554874059000,"deprecated":false,"name":"O-phosphoseryl-tRNA(Sec) selenium transferase","accession":"Q9HD40","gene":"SEPSECS","description":"Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1136237857407583,"antibodyCount":120,"monoclonalCount":6,"pubmedCount":null,"jensenScore":120.507818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.917274385382516,"pubTatorScore":1.9199327012181355,"self":"https://pharos.nih.gov/idg/api/v1/targets(2780)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(2780)/publications"},"_namespace":null},{"id":2781,"version":2,"created":1554874059000,"modified":1554874061000,"deprecated":false,"name":"Cadherin-22","accession":"Q9UJ99","gene":"CDH22","description":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8431649262756314,"antibodyCount":102,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.752219,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.57981923681721,"pubTatorScore":0.7286064110947115,"self":"https://pharos.nih.gov/idg/api/v1/targets(2781)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/properties"},"_links":{"count":735,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(2781)/publications"},"_namespace":null},{"id":2782,"version":2,"created":1554874062000,"modified":1554874064000,"deprecated":false,"name":"Receptor-type tyrosine-protein phosphatase H","accession":"Q9HD43","gene":"PTPRH","description":"Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8969939928865938,"antibodyCount":59,"monoclonalCount":1,"pubmedCount":null,"jensenScore":9.863132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.27058997525867,"pubTatorScore":1.1611539771081292,"self":"https://pharos.nih.gov/idg/api/v1/targets(2782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(2782)/publications"},"_namespace":null},{"id":2783,"version":3,"created":1554874065000,"modified":1555034303000,"deprecated":false,"name":"Transmembrane protein 41B","accession":"Q5BJD5","gene":"TMEM41B","description":"Required for normal motor neuron development.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":8,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.870725646592682,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2783)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(2783)/publications"},"_namespace":null},{"id":2784,"version":3,"created":1554874067000,"modified":1555034305000,"deprecated":false,"name":"Cytochrome P450 4F12","accession":"Q9HCS2","gene":"CYP4F12","description":"Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8879446482360372,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.482389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.35759890269329,"pubTatorScore":1.222015026510251,"self":"https://pharos.nih.gov/idg/api/v1/targets(2784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(2784)/publications"},"_namespace":null},{"id":2785,"version":2,"created":1554874070000,"modified":1554874073000,"deprecated":false,"name":"Charged multivesicular body protein 1a","accession":"Q9HD42","gene":"CHMP1A","description":"Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1557105620552068,"antibodyCount":161,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.919284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.15146936401897,"pubTatorScore":1.2294812579033902,"self":"https://pharos.nih.gov/idg/api/v1/targets(2785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(2785)/publications"},"_namespace":null},{"id":2786,"version":2,"created":1554874074000,"modified":1554874076000,"deprecated":false,"name":"Cohesin subunit SA-3","accession":"Q9UJ98","gene":"STAG3","description":"Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3005531416341467,"antibodyCount":104,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.018984,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.188160549211105,"pubTatorScore":0.9972835658976497,"self":"https://pharos.nih.gov/idg/api/v1/targets(2786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(2786)/publications"},"_namespace":null},{"id":2787,"version":2,"created":1554874077000,"modified":1554874079000,"deprecated":false,"name":"Cell surface hyaluronidase","accession":"Q9UHN6","gene":"TMEM2","description":"Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). 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Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0110600210387306,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.807419,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.484888720078544,"pubTatorScore":0.35057090479655373,"self":"https://pharos.nih.gov/idg/api/v1/targets(2787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(2787)/publications"},"_namespace":null},{"id":2788,"version":2,"created":1554874080000,"modified":1554874081000,"deprecated":false,"name":"Solute carrier family 25 member 53","accession":"Q5H9E4","gene":"SLC25A53","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":null,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.111138547596703,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(2788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(2788)/publications"},"_namespace":null},{"id":2789,"version":2,"created":1554874081000,"modified":1554874083000,"deprecated":false,"name":"Calsenilin","accession":"Q9Y2W7","gene":"KCNIP3","description":"May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.7230970021733263,"antibodyCount":369,"monoclonalCount":40,"pubmedCount":null,"jensenScore":55.992714,"patentCount":1800,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.92187980632766,"pubTatorScore":2.9930542957079744,"self":"https://pharos.nih.gov/idg/api/v1/targets(2789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(2789)/publications"},"_namespace":null},{"id":2790,"version":3,"created":1554874084000,"modified":1555034306000,"deprecated":false,"name":"Tudor and KH domain-containing protein","accession":"Q9Y2W6","gene":"TDRKH","description":"Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. 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May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.5097640823879783,"antibodyCount":38,"monoclonalCount":6,"pubmedCount":null,"jensenScore":3.514888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.263571566050516,"pubTatorScore":0.39694851260152836,"self":"https://pharos.nih.gov/idg/api/v1/targets(2790)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(2790)/publications"},"_namespace":null},{"id":2791,"version":2,"created":1554874088000,"modified":1554874088000,"deprecated":false,"name":"Uncharacterized protein C2orf74","accession":"A8MZ97","gene":"C2orf74","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.1282666794672542,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.325408,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.8964596713017872,"self":"https://pharos.nih.gov/idg/api/v1/targets(2791)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/properties"},"_links":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(2791)/publications"},"_namespace":null},{"id":2792,"version":3,"created":1554874088000,"modified":1555034308000,"deprecated":false,"name":"RNA-binding motif protein, X-linked 2","accession":"Q9Y388","gene":"RBMX2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.054792907340499,"antibodyCount":102,"monoclonalCount":1,"pubmedCount":null,"jensenScore":11.963031,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":26.26439508508208,"pubTatorScore":0.49279613655473026,"self":"https://pharos.nih.gov/idg/api/v1/targets(2792)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(2792)/publications"},"_namespace":null},{"id":2793,"version":2,"created":1554874091000,"modified":1554874093000,"deprecated":false,"name":"Endonuclease/exonuclease/phosphatase family domain-containing protein 1","accession":"Q7L9B9","gene":"EEPD1","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5584514183144745,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.447115,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.498658550752104,"pubTatorScore":0.057991892690873126,"self":"https://pharos.nih.gov/idg/api/v1/targets(2793)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(2793)/publications"},"_namespace":null},{"id":2794,"version":2,"created":1554874094000,"modified":1554874096000,"deprecated":false,"name":"Protein BEX1","accession":"Q9HBH7","gene":"BEX1","description":"Signaling adapter molecule involved in p75NTR/NGFR signaling. 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