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Also component of the CD9-positive microvesicules found in the cauda region.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3325258932811215,"antibodyCount":139,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.039319,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.249325149625278,"pubTatorScore":0.01590479657315158,"self":"https://pharos.nih.gov/idg/api/v1/targets(20001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(20001)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(20001)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(20001)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(20001)/publications"},"_namespace":null},{"id":20002,"version":2,"created":1555027508000,"modified":1555027514000,"deprecated":false,"name":"Probable Xaa-Pro aminopeptidase 3","accession":"Q9NQH7","gene":"XPNPEP3","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2555213663283376,"antibodyCount":113,"monoclonalCount":22,"pubmedCount":null,"jensenScore":17.279338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.637703511841934,"pubTatorScore":1.3026661542844202,"self":"https://pharos.nih.gov/idg/api/v1/targets(20002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(20002)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(20002)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(20002)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(20002)/publications"},"_namespace":null},{"id":20003,"version":3,"created":1555027515000,"modified":1555045613000,"deprecated":false,"name":"Microtubule-associated protein RP/EB family member 1","accession":"Q15691","gene":"MAPRE1","description":"Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). 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Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9896505942842472,"antibodyCount":76,"monoclonalCount":9,"pubmedCount":null,"jensenScore":8.163941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":28.77029710933866,"pubTatorScore":0.9628977924179976,"self":"https://pharos.nih.gov/idg/api/v1/targets(20005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(20005)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(20005)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(20005)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(20005)/publications"},"_namespace":null},{"id":20006,"version":2,"created":1555027529000,"modified":1555027533000,"deprecated":false,"name":"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1","accession":"Q15695","gene":"ZRSR2P1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3612779836525837,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.599824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.7659167691498038,"self":"https://pharos.nih.gov/idg/api/v1/targets(20006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(20006)/properties"},"_links":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(20006)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(20006)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(20006)/publications"},"_namespace":null},{"id":20007,"version":3,"created":1555027534000,"modified":1555045617000,"deprecated":false,"name":"Striatin-3","accession":"Q13033","gene":"STRN3","description":"Binds calmodulin in a calcium dependent manner. 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Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5593599176280937,"antibodyCount":127,"monoclonalCount":18,"pubmedCount":null,"jensenScore":33.675574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.501448216115357,"pubTatorScore":1.487290380234421,"self":"https://pharos.nih.gov/idg/api/v1/targets(20011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/properties"},"_links":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(20011)/publications"},"_namespace":null},{"id":20012,"version":3,"created":1555027556000,"modified":1555045620000,"deprecated":false,"name":"ATP synthase mitochondrial F1 complex assembly factor 2","accession":"Q8N5M1","gene":"ATPAF2","description":"May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1550598857613392,"antibodyCount":85,"monoclonalCount":21,"pubmedCount":null,"jensenScore":13.842893,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":36.2073731941181,"pubTatorScore":0.865301406361885,"self":"https://pharos.nih.gov/idg/api/v1/targets(20012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(20012)/publications"},"_namespace":null},{"id":20013,"version":2,"created":1555027561000,"modified":1555027565000,"deprecated":false,"name":"Huntingtin-associated protein 1","accession":"P54257","gene":"HAP1","description":"Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9179262349779131,"antibodyCount":162,"monoclonalCount":29,"pubmedCount":null,"jensenScore":84.129009,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.730187099772515,"pubTatorScore":2.062077353064466,"self":"https://pharos.nih.gov/idg/api/v1/targets(20013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(20013)/publications"},"_namespace":null},{"id":20014,"version":3,"created":1555027566000,"modified":1555045624000,"deprecated":false,"name":"Tetratricopeptide repeat protein 9C","accession":"Q8N5M4","gene":"TTC9C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0413926851582251,"antibodyCount":82,"monoclonalCount":6,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":43,"knowledgeAvailability":28.982828623164348,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(20014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(20014)/publications"},"_namespace":null},{"id":20015,"version":3,"created":1555027570000,"modified":1555045625000,"deprecated":false,"name":"Calcium-binding and spermatid-specific protein 1","accession":"Q96KC9","gene":"CABS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.5692675474187776,"antibodyCount":47,"monoclonalCount":3,"pubmedCount":null,"jensenScore":37.51425,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":16.627559198524416,"pubTatorScore":1.1383026981662814,"self":"https://pharos.nih.gov/idg/api/v1/targets(20015)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/properties"},"_links":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(20015)/publications"},"_namespace":null},{"id":20016,"version":3,"created":1555027572000,"modified":1555045627000,"deprecated":false,"name":"Ataxin-3","accession":"P54252","gene":"ATXN3","description":"Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). 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Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.636203813035483,"antibodyCount":327,"monoclonalCount":102,"pubmedCount":null,"jensenScore":474.234086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":55.79223853330273,"pubTatorScore":2.813620439528004,"self":"https://pharos.nih.gov/idg/api/v1/targets(20044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1156,"href":"https://pharos.nih.gov/idg/api/v1/targets(20044)/properties"},"_links":{"count":1629,"href":"https://pharos.nih.gov/idg/api/v1/targets(20044)/links"},"_synonyms":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(20044)/synonyms"},"_publications":{"count":615,"href":"https://pharos.nih.gov/idg/api/v1/targets(20044)/publications"},"_namespace":null},{"id":20045,"version":2,"created":1555027745000,"modified":1555027751000,"deprecated":false,"name":"CAP-Gly domain-containing linker protein 2","accession":"Q9UDT6","gene":"CLIP2","description":"Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. 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Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.517839730542383,"antibodyCount":116,"monoclonalCount":2,"pubmedCount":null,"jensenScore":32.660954,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":35.94991916181057,"pubTatorScore":0.7563280378221116,"self":"https://pharos.nih.gov/idg/api/v1/targets(20046)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(20046)/publications"},"_namespace":null},{"id":20047,"version":3,"created":1555027760000,"modified":1555045654000,"deprecated":false,"name":"Butyrophilin-like protein 8","accession":"Q6UX41","gene":"BTNL8","description":"May stimulate primary immune response. 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After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. 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Endogenous Pol proteins may have kept, lost or modified their original function during evolution.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(20191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(20191)/publications"},"_namespace":null},{"id":20192,"version":3,"created":1555028711000,"modified":1555045756000,"deprecated":false,"name":"Translin","accession":"Q15631","gene":"TSN","description":"Exhibits both single-stranded and double-stranded endoribonuclease activity. 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Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. 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Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1314954516383278,"antibodyCount":551,"monoclonalCount":96,"pubmedCount":null,"jensenScore":113.843157,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":46.41812845365866,"pubTatorScore":1.9059659016960395,"self":"https://pharos.nih.gov/idg/api/v1/targets(20238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(20238)/properties"},"_links":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(20238)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(20238)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(20238)/publications"},"_namespace":null},{"id":20239,"version":2,"created":1555029619000,"modified":1555029621000,"deprecated":false,"name":"Putative short-chain dehydrogenase/reductase family 42E member 2","accession":"A6NKP2","gene":"SDR42E2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.8809523840470452,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(20239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(20239)/properties"},"_links":{"count":650,"href":"https://pharos.nih.gov/idg/api/v1/targets(20239)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(20239)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(20239)/publications"},"_namespace":null},{"id":20240,"version":2,"created":1555029622000,"modified":1555029628000,"deprecated":false,"name":"Probable JmjC domain-containing histone demethylation protein 2C","accession":"Q15652","gene":"JMJD1C","description":"Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.2297017354583037,"antibodyCount":98,"monoclonalCount":28,"pubmedCount":null,"jensenScore":20.172866,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.64789154286577,"pubTatorScore":1.17552381572867,"self":"https://pharos.nih.gov/idg/api/v1/targets(20240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(20240)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(20240)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(20240)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(20240)/publications"},"_namespace":null},{"id":20241,"version":2,"created":1555029630000,"modified":1555029634000,"deprecated":false,"name":"Protein FAM50A","accession":"Q14320","gene":"FAM50A","description":"May be a DNA-binding protein or transcriptional factor.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6686591660452911,"antibodyCount":165,"monoclonalCount":37,"pubmedCount":null,"jensenScore":4.850141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.941649570687375,"pubTatorScore":0.7020610566723383,"self":"https://pharos.nih.gov/idg/api/v1/targets(20241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(20241)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(20241)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(20241)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(20241)/publications"},"_namespace":null},{"id":20242,"version":2,"created":1555029635000,"modified":1555029640000,"deprecated":false,"name":"High mobility group nucleosome-binding domain-containing protein 3","accession":"Q15651","gene":"HMGN3","description":"Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1081390883318016,"antibodyCount":125,"monoclonalCount":4,"pubmedCount":null,"jensenScore":12.525263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.99213045282007,"pubTatorScore":0.9348389863714794,"self":"https://pharos.nih.gov/idg/api/v1/targets(20242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(20242)/publications"},"_namespace":null},{"id":20243,"version":2,"created":1555029641000,"modified":1555029647000,"deprecated":false,"name":"Activating signal cointegrator 1","accession":"Q15650","gene":"TRIP4","description":"Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. 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