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Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4444970954367644,"antibodyCount":251,"monoclonalCount":23,"pubmedCount":null,"jensenScore":28.376418,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.00286138157577,"pubTatorScore":1.3138671782046385,"self":"https://pharos.nih.gov/idg/api/v1/targets(19001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(19001)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(19001)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(19001)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(19001)/publications"},"_namespace":null},{"id":19002,"version":2,"created":1555019128000,"modified":1555019133000,"deprecated":false,"name":"Sialic acid synthase","accession":"Q9NR45","gene":"NANS","description":"Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). 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In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6988397355307918,"antibodyCount":158,"monoclonalCount":4,"pubmedCount":null,"jensenScore":46.849505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.61870979024133,"pubTatorScore":1.5268646496910077,"self":"https://pharos.nih.gov/idg/api/v1/targets(19005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(19005)/properties"},"_links":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(19005)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19005)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(19005)/publications"},"_namespace":null},{"id":19006,"version":3,"created":1555019149000,"modified":1555044989000,"deprecated":false,"name":"C-X-C motif chemokine 2","accession":"P19875","gene":"CXCL2","description":"Produced by activated monocytes and neutrophils and expressed at sites of inflammation. 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Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9581176278796086,"antibodyCount":192,"monoclonalCount":9,"pubmedCount":null,"jensenScore":81.910999,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":30.294238140893093,"pubTatorScore":1.6182454622469336,"self":"https://pharos.nih.gov/idg/api/v1/targets(19008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(19008)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(19008)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(19008)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(19008)/publications"},"_namespace":null},{"id":19009,"version":3,"created":1555019170000,"modified":1555044993000,"deprecated":false,"name":"Inner centromere protein","accession":"Q9NQS7","gene":"INCENP","description":"Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.038430843876737,"antibodyCount":126,"monoclonalCount":40,"pubmedCount":null,"jensenScore":97.506191,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":44.25608918285495,"pubTatorScore":1.8307795495135175,"self":"https://pharos.nih.gov/idg/api/v1/targets(19009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(19009)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(19009)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(19009)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(19009)/publications"},"_namespace":null},{"id":19010,"version":2,"created":1555019176000,"modified":1555019180000,"deprecated":false,"name":"Protein FAM131A","accession":"Q6UXB0","gene":"FAM131A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.328093398488484,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(19010)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(19010)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(19010)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(19010)/publications"},"_namespace":null},{"id":19011,"version":2,"created":1555019181000,"modified":1555019187000,"deprecated":false,"name":"Histone-lysine N-methyltransferase ASH1L","accession":"Q9NR48","gene":"ASH1L","description":"Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.2810215962896094,"antibodyCount":111,"monoclonalCount":13,"pubmedCount":null,"jensenScore":19.766574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.843274826193586,"pubTatorScore":1.4032907724354782,"self":"https://pharos.nih.gov/idg/api/v1/targets(19011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(19011)/properties"},"_links":{"count":1004,"href":"https://pharos.nih.gov/idg/api/v1/targets(19011)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(19011)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(19011)/publications"},"_namespace":null},{"id":19012,"version":2,"created":1555019188000,"modified":1555019192000,"deprecated":false,"name":"Bactericidal permeability-increasing protein","accession":"P17213","gene":"BPI","description":"The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. 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Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.50531677942882,"antibodyCount":1102,"monoclonalCount":740,"pubmedCount":null,"jensenScore":3420.908916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":44.5215726745551,"pubTatorScore":3.2237410148120276,"self":"https://pharos.nih.gov/idg/api/v1/targets(19064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1680,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/properties"},"_links":{"count":2167,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/synonyms"},"_publications":{"count":1261,"href":"https://pharos.nih.gov/idg/api/v1/targets(19064)/publications"},"_namespace":null},{"id":19065,"version":3,"created":1555019546000,"modified":1555045034000,"deprecated":false,"name":"Adenylyltransferase and sulfurtransferase MOCS3","accession":"O95396","gene":"MOCS3","description":"Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0867833952357453,"antibodyCount":128,"monoclonalCount":35,"pubmedCount":null,"jensenScore":10.918263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":34.78960387876799,"pubTatorScore":0.9976151370397195,"self":"https://pharos.nih.gov/idg/api/v1/targets(19065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(19065)/publications"},"_namespace":null},{"id":19066,"version":2,"created":1555019550000,"modified":1555019553000,"deprecated":false,"name":"CCAAT/enhancer-binding protein zeta","accession":"Q03701","gene":"CEBPZ","description":"Stimulates transcription from the HSP70 promoter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8404294984415146,"antibodyCount":126,"monoclonalCount":3,"pubmedCount":null,"jensenScore":65.823589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.505262155592526,"pubTatorScore":2.3204825803275275,"self":"https://pharos.nih.gov/idg/api/v1/targets(19066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(19066)/publications"},"_namespace":null},{"id":19067,"version":3,"created":1555019554000,"modified":1555045035000,"deprecated":false,"name":"Toll-like receptor 5","accession":"O60602","gene":"TLR5","description":"Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7928020310007335,"antibodyCount":691,"monoclonalCount":275,"pubmedCount":null,"jensenScore":635.609353,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":41.42984169693781,"pubTatorScore":2.4552673250911106,"self":"https://pharos.nih.gov/idg/api/v1/targets(19067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/synonyms"},"_publications":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(19067)/publications"},"_namespace":null},{"id":19068,"version":2,"created":1555019560000,"modified":1555019563000,"deprecated":false,"name":"Membrane protein FAM159A","accession":"Q6UWV7","gene":"SHISAL2A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/properties"},"_links":{"count":653,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(19068)/publications"},"_namespace":null},{"id":19069,"version":2,"created":1555019563000,"modified":1555019565000,"deprecated":false,"name":"Protein PIH1D3","accession":"Q9NQM4","gene":"PIH1D3","description":"Plays a role in cytoplasmic pre-assembly of axonemal dynein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2846992279675036,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.989286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.29426768657019,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/properties"},"_links":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(19069)/publications"},"_namespace":null},{"id":19070,"version":2,"created":1555019565000,"modified":1555019571000,"deprecated":false,"name":"Multiple epidermal growth factor-like domains protein 10","accession":"Q96KG7","gene":"MEGF10","description":"Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3419586332852893,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.898199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.37396671451192,"pubTatorScore":1.210868839285683,"self":"https://pharos.nih.gov/idg/api/v1/targets(19070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(19070)/publications"},"_namespace":null},{"id":19071,"version":3,"created":1555019571000,"modified":1555019580000,"deprecated":false,"name":"Acetyl-CoA carboxylase 1","accession":"Q13085","gene":"ACACA","description":"Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. 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Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4254879738989908,"antibodyCount":41,"monoclonalCount":10,"pubmedCount":null,"jensenScore":3.992227,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.04931269063043,"pubTatorScore":0.7588577913707819,"self":"https://pharos.nih.gov/idg/api/v1/targets(19134)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(19134)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(19134)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(19134)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(19134)/publications"},"_namespace":null},{"id":19135,"version":2,"created":1555019938000,"modified":1555019951000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily S member 1","accession":"Q96KK3","gene":"KCNS1","description":"Potassium channel subunit that does not form functional channels by itself. 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The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5409786306317814,"antibodyCount":92,"monoclonalCount":12,"pubmedCount":null,"jensenScore":317.438117,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":47.17152609224794,"pubTatorScore":2.3591172731171177,"self":"https://pharos.nih.gov/idg/api/v1/targets(19187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":571,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/properties"},"_links":{"count":1296,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/synonyms"},"_publications":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(19187)/publications"},"_namespace":null},{"id":19188,"version":3,"created":1555020180000,"modified":1555045094000,"deprecated":false,"name":"Protein delta homolog 2","accession":"Q6UY11","gene":"DLK2","description":"Regulates adipogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7730033541052158,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.460833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":27.461806966863307,"pubTatorScore":0.03302305466873799,"self":"https://pharos.nih.gov/idg/api/v1/targets(19188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/properties"},"_links":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(19188)/publications"},"_namespace":null},{"id":19189,"version":3,"created":1555020183000,"modified":1555045095000,"deprecated":false,"name":"(E3-independent) E2 ubiquitin-conjugating enzyme","accession":"Q9C0C9","gene":"UBE2O","description":"E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0791538516157178,"antibodyCount":104,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.607705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.599395356841185,"pubTatorScore":0.5826314394896365,"self":"https://pharos.nih.gov/idg/api/v1/targets(19189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(19189)/publications"},"_namespace":null},{"id":19190,"version":2,"created":1555020189000,"modified":1555020190000,"deprecated":false,"name":"Transmembrane protein 14EP","accession":"Q6UXP3","gene":"TMEM14EP","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/properties"},"_links":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/links"},"_synonyms":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(19190)/publications"},"_namespace":null},{"id":19191,"version":3,"created":1555020190000,"modified":1555045096000,"deprecated":false,"name":"CLOCK-interacting pacemaker","accession":"Q9C0C6","gene":"CIPC","description":"Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. 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The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. 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Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.2667545718175552,"antibodyCount":1396,"monoclonalCount":234,"pubmedCount":null,"jensenScore":1515.740982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":60.00651512753951,"pubTatorScore":2.7141398393111382,"self":"https://pharos.nih.gov/idg/api/v1/targets(19236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/properties"},"_links":{"count":1511,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/synonyms"},"_publications":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(19236)/publications"},"_namespace":null},{"id":19237,"version":3,"created":1555020510000,"modified":1555045128000,"deprecated":false,"name":"5'-AMP-activated protein kinase catalytic subunit alpha-1","accession":"Q13131","gene":"PRKAA1","description":"Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.9282357834409767,"antibodyCount":953,"monoclonalCount":183,"pubmedCount":null,"jensenScore":74.344626,"patentCount":2819,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":56.443209744834704,"pubTatorScore":2.579215918311512,"self":"https://pharos.nih.gov/idg/api/v1/targets(19237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/properties"},"_links":{"count":1371,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/synonyms"},"_publications":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(19237)/publications"},"_namespace":null},{"id":19238,"version":2,"created":1555020525000,"modified":1555020532000,"deprecated":false,"name":"Alpha-ketoglutarate-dependent dioxygenase FTO","accession":"Q9C0B1","gene":"FTO","description":"Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). In particular, it is involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.1302110976303124,"antibodyCount":318,"monoclonalCount":63,"pubmedCount":null,"jensenScore":1342.048711,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.06266046942067,"pubTatorScore":3.032182221411047,"self":"https://pharos.nih.gov/idg/api/v1/targets(19238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/properties"},"_links":{"count":1673,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/synonyms"},"_publications":{"count":649,"href":"https://pharos.nih.gov/idg/api/v1/targets(19238)/publications"},"_namespace":null},{"id":19239,"version":2,"created":1555020535000,"modified":1555020538000,"deprecated":false,"name":"Cilia- and flagella-associated protein 74","accession":"Q9C0B2","gene":"CFAP74","description":"As part of the central apparatus of the cilium axoneme may play a role in cilium movement.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.38021124171160603,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.160256,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.777030828700669,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/properties"},"_links":{"count":717,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(19239)/publications"},"_namespace":null},{"id":19240,"version":2,"created":1555020539000,"modified":1555020545000,"deprecated":false,"name":"Transcription factor HES-1","accession":"Q14469","gene":"HES1","description":"Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7740885523365773,"antibodyCount":444,"monoclonalCount":158,"pubmedCount":null,"jensenScore":55.536295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.353035556015655,"pubTatorScore":2.518945596934086,"self":"https://pharos.nih.gov/idg/api/v1/targets(19240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":496,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/synonyms"},"_publications":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(19240)/publications"},"_namespace":null},{"id":19241,"version":3,"created":1555020547000,"modified":1555045131000,"deprecated":false,"name":"Calcium-binding and coiled-coil domain-containing protein 2","accession":"Q13137","gene":"CALCOCO2","description":"Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.413701946247204,"antibodyCount":255,"monoclonalCount":185,"pubmedCount":null,"jensenScore":234.003383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":37.21787078864689,"pubTatorScore":1.4004889450192652,"self":"https://pharos.nih.gov/idg/api/v1/targets(19241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/properties"},"_links":{"count":1143,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(19241)/publications"},"_namespace":null},{"id":19242,"version":3,"created":1555020553000,"modified":1555045133000,"deprecated":false,"name":"Mothers against decapentaplegic homolog 1","accession":"Q15797","gene":"SMAD1","description":"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.9357609353861517,"antibodyCount":897,"monoclonalCount":136,"pubmedCount":null,"jensenScore":6.899748,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":50.867274936435685,"pubTatorScore":2.196006962445458,"self":"https://pharos.nih.gov/idg/api/v1/targets(19242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":634,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/properties"},"_links":{"count":1156,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/synonyms"},"_publications":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(19242)/publications"},"_namespace":null},{"id":19243,"version":3,"created":1555020560000,"modified":1555045135000,"deprecated":false,"name":"Liprin-alpha-1","accession":"Q13136","gene":"PPFIA1","description":"May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6322213602259907,"antibodyCount":131,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.971909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":45.760577295871826,"pubTatorScore":1.6568456953210529,"self":"https://pharos.nih.gov/idg/api/v1/targets(19243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(19243)/publications"},"_namespace":null},{"id":19244,"version":3,"created":1555020568000,"modified":1555045136000,"deprecated":false,"name":"Polynucleotide 5'-hydroxyl-kinase NOL9","accession":"Q5SY16","gene":"NOL9","description":"Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.0914156945232518,"antibodyCount":29,"monoclonalCount":1,"pubmedCount":null,"jensenScore":11.051948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":36.4502118279985,"pubTatorScore":0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(19244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(19244)/publications"},"_namespace":null},{"id":19245,"version":2,"created":1555020573000,"modified":1555020575000,"deprecated":false,"name":"EP300-interacting inhibitor of differentiation 2","accession":"Q8N6I1","gene":"EID2","description":"Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. 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May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3664229843693787,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.133264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.11820278277214,"pubTatorScore":1.3024752437523561,"self":"https://pharos.nih.gov/idg/api/v1/targets(19245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19245)/publications"},"_namespace":null},{"id":19246,"version":2,"created":1555020576000,"modified":1555020577000,"deprecated":false,"name":"Putative uncharacterized protein encoded by COL5A1-AS1","accession":"Q5SY13","gene":"COL5A1-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.8491363490076624,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19246)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(19246)/publications"},"_namespace":null},{"id":19247,"version":3,"created":1555020577000,"modified":1555045137000,"deprecated":false,"name":"Protein HIRA","accession":"P54198","gene":"HIRA","description":"Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6251816594230253,"antibodyCount":188,"monoclonalCount":30,"pubmedCount":null,"jensenScore":39.917511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.864778202272205,"pubTatorScore":1.9339647694477422,"self":"https://pharos.nih.gov/idg/api/v1/targets(19247)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/properties"},"_links":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(19247)/publications"},"_namespace":null},{"id":19248,"version":3,"created":1555020584000,"modified":1555045139000,"deprecated":false,"name":"TOMM20-like protein 1","accession":"Q6UXN7","gene":"TOMM20L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":57,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":19.01871869294766,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/properties"},"_links":{"count":699,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(19248)/publications"},"_namespace":null},{"id":19249,"version":2,"created":1555020586000,"modified":1555020588000,"deprecated":false,"name":"CMRF35-like molecule 7","accession":"A8K4G0","gene":"CD300LB","description":"Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8524218899644638,"antibodyCount":74,"monoclonalCount":4,"pubmedCount":null,"jensenScore":10.394955,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.379594054933474,"pubTatorScore":0.6582763786101274,"self":"https://pharos.nih.gov/idg/api/v1/targets(19249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/properties"},"_links":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(19249)/publications"},"_namespace":null},{"id":19250,"version":2,"created":1555020588000,"modified":1555020591000,"deprecated":false,"name":"WD repeat-containing protein 82","accession":"Q6UXN9","gene":"WDR82","description":"Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. 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Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1388588424682835,"antibodyCount":339,"monoclonalCount":40,"pubmedCount":null,"jensenScore":158.918806,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":29,"knowledgeAvailability":39.557551086009276,"pubTatorScore":3.3061619700431093,"self":"https://pharos.nih.gov/idg/api/v1/targets(19336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(19336)/publications"},"_namespace":null},{"id":19337,"version":2,"created":1555021148000,"modified":1555021151000,"deprecated":false,"name":"Germ cell-specific gene 1-like protein","accession":"Q6UXU4","gene":"GSG1L","description":"As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6977996607389556,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.033,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.753793318868023,"pubTatorScore":0.10833936198506207,"self":"https://pharos.nih.gov/idg/api/v1/targets(19337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/properties"},"_links":{"count":776,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(19337)/publications"},"_namespace":null},{"id":19338,"version":3,"created":1555021151000,"modified":1555045185000,"deprecated":false,"name":"Zeta-sarcoglycan","accession":"Q96LD1","gene":"SGCZ","description":"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. 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During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. 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The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.","idgFamily":"Nuclear Receptor","idgTDL":"Tclin","novelty":-2.4828542666198055,"antibodyCount":299,"monoclonalCount":99,"pubmedCount":null,"jensenScore":237.893733,"patentCount":8536,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":58.14639597024445,"pubTatorScore":3.145644798584117,"self":"https://pharos.nih.gov/idg/api/v1/targets(19437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":832,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/properties"},"_links":{"count":1464,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/links"},"_synonyms":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/synonyms"},"_publications":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(19437)/publications"},"_namespace":null},{"id":19438,"version":3,"created":1555021713000,"modified":1555045234000,"deprecated":false,"name":"Transmembrane protein 108","accession":"Q6UXF1","gene":"TMEM108","description":"Transmembrane protein required for proper cognitive functions. 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Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.02996322279838387,"antibodyCount":155,"monoclonalCount":30,"pubmedCount":null,"jensenScore":1.295238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.902492644625568,"pubTatorScore":0.06694654146226692,"self":"https://pharos.nih.gov/idg/api/v1/targets(19711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(19711)/publications"},"_namespace":null},{"id":19712,"version":3,"created":1555025100000,"modified":1555045420000,"deprecated":false,"name":"CD70 antigen","accession":"P32970","gene":"CD70","description":"Cytokine that binds to CD27. 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Also involved in G2/M progression and cytokinesis.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.0408087780685533,"antibodyCount":419,"monoclonalCount":84,"pubmedCount":null,"jensenScore":103.630478,"patentCount":12192,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":54.50083982612412,"pubTatorScore":1.9399232031678026,"self":"https://pharos.nih.gov/idg/api/v1/targets(19868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(19868)/publications"},"_namespace":null},{"id":19869,"version":4,"created":1555026672000,"modified":1555045531000,"deprecated":false,"name":"Proto-oncogene tyrosine-protein kinase receptor Ret","accession":"P07949","gene":"RET","description":"Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.4280118192439217,"antibodyCount":880,"monoclonalCount":256,"pubmedCount":null,"jensenScore":2821.419851,"patentCount":180270,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":58.632163368423384,"pubTatorScore":3.5294865656836096,"self":"https://pharos.nih.gov/idg/api/v1/targets(19869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1234,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/properties"},"_links":{"count":1863,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/synonyms"},"_publications":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(19869)/publications"},"_namespace":null},{"id":19870,"version":3,"created":1555026716000,"modified":1555045536000,"deprecated":false,"name":"Tyrosine-protein kinase Lyn","accession":"P07948","gene":"LYN","description":"Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.836439114738024,"antibodyCount":589,"monoclonalCount":121,"pubmedCount":null,"jensenScore":683.181822,"patentCount":59678,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":62.50683905622742,"pubTatorScore":2.6408893569299225,"self":"https://pharos.nih.gov/idg/api/v1/targets(19870)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/properties"},"_links":{"count":1186,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/synonyms"},"_publications":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(19870)/publications"},"_namespace":null},{"id":19871,"version":2,"created":1555026734000,"modified":1555026738000,"deprecated":false,"name":"Zinc finger MYM-type protein 1","accession":"Q5SVZ6","gene":"ZMYM1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.32307958618782,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19871)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/properties"},"_links":{"count":799,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(19871)/publications"},"_namespace":null},{"id":19872,"version":3,"created":1555026738000,"modified":1555045538000,"deprecated":false,"name":"Myelin-associated glycoprotein","accession":"P20916","gene":"MAG","description":"Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.9504408799361865,"antibodyCount":257,"monoclonalCount":45,"pubmedCount":null,"jensenScore":775.043081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":31.430765632284096,"pubTatorScore":2.7542916734061973,"self":"https://pharos.nih.gov/idg/api/v1/targets(19872)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(19872)/publications"},"_namespace":null},{"id":19873,"version":2,"created":1555026749000,"modified":1555026749000,"deprecated":false,"name":"Protein FAM27E3","accession":"Q08E93","gene":"FAM27E3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.307969591754636,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(19873)/publications"},"_namespace":null},{"id":19874,"version":2,"created":1555026749000,"modified":1555026754000,"deprecated":false,"name":"Frizzled-3","accession":"Q9NPG1","gene":"FZD3","description":"Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.7652828250597803,"antibodyCount":314,"monoclonalCount":53,"pubmedCount":null,"jensenScore":56.437018,"patentCount":5487,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.84678063011598,"pubTatorScore":1.6256619482274184,"self":"https://pharos.nih.gov/idg/api/v1/targets(19874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(19874)/publications"},"_namespace":null},{"id":19875,"version":3,"created":1555026755000,"modified":1555045540000,"deprecated":false,"name":"Neuroglobin","accession":"Q9NPG2","gene":"NGB","description":"Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5455438932066303,"antibodyCount":196,"monoclonalCount":21,"pubmedCount":null,"jensenScore":397.848093,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":22.80411916899304,"pubTatorScore":2.401752073598697,"self":"https://pharos.nih.gov/idg/api/v1/targets(19875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/properties"},"_links":{"count":615,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(19875)/publications"},"_namespace":null},{"id":19876,"version":2,"created":1555026761000,"modified":1555026766000,"deprecated":false,"name":"Ubinuclein-1","accession":"Q9NPG3","gene":"UBN1","description":"Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5243137060432528,"antibodyCount":87,"monoclonalCount":20,"pubmedCount":null,"jensenScore":27.527865,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.72713065857093,"pubTatorScore":1.170831909968437,"self":"https://pharos.nih.gov/idg/api/v1/targets(19876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(19876)/publications"},"_namespace":null},{"id":19877,"version":3,"created":1555026767000,"modified":1555045541000,"deprecated":false,"name":"Protocadherin-12","accession":"Q9NPG4","gene":"PCDH12","description":"Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9364127074563352,"antibodyCount":72,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.190273,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":30.092195572854298,"pubTatorScore":0.6004470702839172,"self":"https://pharos.nih.gov/idg/api/v1/targets(19877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(19877)/publications"},"_namespace":null},{"id":19878,"version":3,"created":1555026771000,"modified":1555045543000,"deprecated":false,"name":"Coiled-coil domain-containing protein 82","accession":"Q8N4S0","gene":"CCDC82","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.052632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":28.62303942524901,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(19878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(19878)/publications"},"_namespace":null},{"id":19879,"version":2,"created":1555026776000,"modified":1555026779000,"deprecated":false,"name":"Probable palmitoyltransferase ZDHHC4","accession":"Q9NPG8","gene":"ZDHHC4","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.7496763827231845,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":55.109533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.48484137060833,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(19879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(19879)/publications"},"_namespace":null},{"id":19880,"version":2,"created":1555026780000,"modified":1555026784000,"deprecated":false,"name":"Prolyl 3-hydroxylase OGFOD1","accession":"Q8N543","gene":"OGFOD1","description":"Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. 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Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.44380970646793,"antibodyCount":357,"monoclonalCount":113,"pubmedCount":null,"jensenScore":269.903635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":40.14691569834221,"pubTatorScore":2.104056690485035,"self":"https://pharos.nih.gov/idg/api/v1/targets(19898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(19898)/publications"},"_namespace":null},{"id":19899,"version":2,"created":1555026910000,"modified":1555026912000,"deprecated":false,"name":"Protein ARMCX6","accession":"Q7L4S7","gene":"ARMCX6","description":"May regulate the dynamics and distribution of mitochondria in neural cells.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.337729904320117,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(19899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19899)/publications"},"_namespace":null},{"id":19900,"version":2,"created":1555026913000,"modified":1555026917000,"deprecated":false,"name":"Transmembrane protein 138","accession":"Q9NPI0","gene":"TMEM138","description":"Required for ciliogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.24966862972337267,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.746212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.70430207565234,"pubTatorScore":0.03218465235036576,"self":"https://pharos.nih.gov/idg/api/v1/targets(19900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(19900)/publications"},"_namespace":null},{"id":19901,"version":2,"created":1555026917000,"modified":1555026921000,"deprecated":false,"name":"Ubiquinol-cytochrome-c reductase complex assembly factor 3","accession":"Q6UW78","gene":"UQCC3","description":"Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. 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Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. 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Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. 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Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9697310830132702,"antibodyCount":54,"monoclonalCount":3,"pubmedCount":null,"jensenScore":94.963955,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.455312637699558,"pubTatorScore":0.7877807990888366,"self":"https://pharos.nih.gov/idg/api/v1/targets(19906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/properties"},"_links":{"count":1254,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(19906)/publications"},"_namespace":null},{"id":19907,"version":2,"created":1555026943000,"modified":1555026949000,"deprecated":false,"name":"Fanconi anemia group F protein","accession":"Q9NPI8","gene":"FANCF","description":"DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.5806852674233618,"antibodyCount":130,"monoclonalCount":9,"pubmedCount":null,"jensenScore":37.152064,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.47890624197986,"pubTatorScore":1.6486046889424664,"self":"https://pharos.nih.gov/idg/api/v1/targets(19907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(19907)/publications"},"_namespace":null},{"id":19908,"version":3,"created":1555026950000,"modified":1555045554000,"deprecated":false,"name":"Inward rectifier potassium channel 16","accession":"Q9NPI9","gene":"KCNJ16","description":"Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.5896680834514179,"antibodyCount":122,"monoclonalCount":2,"pubmedCount":null,"jensenScore":33.642169,"patentCount":1927,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.99477868677694,"pubTatorScore":1.3439709216140763,"self":"https://pharos.nih.gov/idg/api/v1/targets(19908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/properties"},"_links":{"count":904,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(19908)/publications"},"_namespace":null},{"id":19909,"version":2,"created":1555026958000,"modified":1555026961000,"deprecated":false,"name":"Zinc finger protein 469","accession":"Q96JG9","gene":"ZNF469","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.2571805592844492,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.578678,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.32643111077612,"pubTatorScore":1.3707152383608283,"self":"https://pharos.nih.gov/idg/api/v1/targets(19909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(19909)/publications"},"_namespace":null},{"id":19910,"version":3,"created":1555026962000,"modified":1555045556000,"deprecated":false,"name":"Mitochondrial intermembrane space import and assembly protein 40","accession":"Q8N4Q1","gene":"CHCHD4","description":"Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS) (PubMed:16185709, PubMed:19182799, PubMed:21059946). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria (PubMed:16185709, PubMed:19182799, PubMed:21059946). The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.842140857259102,"antibodyCount":108,"monoclonalCount":7,"pubmedCount":null,"jensenScore":70.612708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":51,"knowledgeAvailability":31.223721060253652,"pubTatorScore":1.6929870513363883,"self":"https://pharos.nih.gov/idg/api/v1/targets(19910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(19910)/publications"},"_namespace":null},{"id":19911,"version":3,"created":1555026966000,"modified":1555045557000,"deprecated":false,"name":"Prostaglandin reductase 3","accession":"Q8N4Q0","gene":"ZADH2","description":"Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. 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