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Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.315834428211756,"antibodyCount":157,"monoclonalCount":5,"pubmedCount":null,"jensenScore":207.284766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.979606774431254,"pubTatorScore":1.6783882715119793,"self":"https://pharos.nih.gov/idg/api/v1/targets(1044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(1044)/publications"},"_namespace":null},{"id":1045,"version":2,"created":1554861939000,"modified":1554861939000,"deprecated":false,"name":"Putative WAS protein family homolog 4","accession":"A8MWX3","gene":"WASH4P","description":"May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.57316843100489,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1045)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/properties"},"_links":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(1045)/publications"},"_namespace":null},{"id":1046,"version":3,"created":1554861940000,"modified":1555032994000,"deprecated":false,"name":"Cathepsin E","accession":"P14091","gene":"CTSE","description":"May have a role in immune function. 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DCX(DTL) directs autoubiquitination of DTL.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9219918462378247,"antibodyCount":276,"monoclonalCount":14,"pubmedCount":null,"jensenScore":80.081602,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":41.552163791548374,"pubTatorScore":1.8199261307098191,"self":"https://pharos.nih.gov/idg/api/v1/targets(1065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(1065)/publications"},"_namespace":null},{"id":1066,"version":3,"created":1554862056000,"modified":1555033008000,"deprecated":false,"name":"Cullin-3","accession":"Q13618","gene":"CUL3","description":"Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.263221168171643,"antibodyCount":307,"monoclonalCount":34,"pubmedCount":null,"jensenScore":1670.770098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":48.46669585230958,"pubTatorScore":2.127632845068227,"self":"https://pharos.nih.gov/idg/api/v1/targets(1066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/properties"},"_links":{"count":1298,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(1066)/publications"},"_namespace":null},{"id":1067,"version":3,"created":1554862061000,"modified":1555033010000,"deprecated":false,"name":"Cullin-2","accession":"Q13617","gene":"CUL2","description":"Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9984363182115807,"antibodyCount":373,"monoclonalCount":13,"pubmedCount":null,"jensenScore":95.098475,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":40.8626395934268,"pubTatorScore":1.973342060409126,"self":"https://pharos.nih.gov/idg/api/v1/targets(1067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/properties"},"_links":{"count":1155,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(1067)/publications"},"_namespace":null},{"id":1068,"version":3,"created":1554862065000,"modified":1555033012000,"deprecated":false,"name":"Cullin-1","accession":"Q13616","gene":"CUL1","description":"Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.379310234214266,"antibodyCount":416,"monoclonalCount":57,"pubmedCount":null,"jensenScore":182.586086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":47.959506528255524,"pubTatorScore":2.206510423237846,"self":"https://pharos.nih.gov/idg/api/v1/targets(1068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":683,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/properties"},"_links":{"count":1175,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/synonyms"},"_publications":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(1068)/publications"},"_namespace":null},{"id":1069,"version":3,"created":1554862070000,"modified":1555033017000,"deprecated":false,"name":"Secretoglobin family 1D member 4","accession":"Q6XE38","gene":"SCGB1D4","description":"Seems to be involved in the regulation of chemotactic cell migration and invasion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.906494265974766,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":797.499692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":7.466500657428454,"pubTatorScore":0.7696234303982586,"self":"https://pharos.nih.gov/idg/api/v1/targets(1069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/properties"},"_links":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(1069)/publications"},"_namespace":null},{"id":1070,"version":3,"created":1554862070000,"modified":1555033017000,"deprecated":false,"name":"m-AAA protease-interacting protein 1, mitochondrial","accession":"Q8WWC4","gene":"MAIP1","description":"Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation (PubMed:27642048). Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1070)/publications"},"_namespace":null},{"id":1071,"version":2,"created":1554862073000,"modified":1554862075000,"deprecated":false,"name":"UHRF1-binding protein 1","accession":"Q6BDS2","gene":"UHRF1BP1","description":"May act as a negative regulator of cell growth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.303306181101351,"antibodyCount":34,"monoclonalCount":1,"pubmedCount":null,"jensenScore":21.973611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.658921808217926,"pubTatorScore":1.174053902676185,"self":"https://pharos.nih.gov/idg/api/v1/targets(1071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(1071)/publications"},"_namespace":null},{"id":1072,"version":4,"created":1554862076000,"modified":1555033020000,"deprecated":false,"name":"Estradiol 17-beta-dehydrogenase 1","accession":"P14061","gene":"HSD17B1","description":"Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3631461666679403,"antibodyCount":198,"monoclonalCount":30,"pubmedCount":null,"jensenScore":220.756662,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":36.330906660087166,"pubTatorScore":2.305999068587153,"self":"https://pharos.nih.gov/idg/api/v1/targets(1072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/properties"},"_links":{"count":1161,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/links"},"_synonyms":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(1072)/publications"},"_namespace":null},{"id":1073,"version":3,"created":1554862176000,"modified":1555033022000,"deprecated":false,"name":"B-lymphocyte antigen CD19","accession":"P15391","gene":"CD19","description":"Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.543345545351551,"antibodyCount":2794,"monoclonalCount":2211,"pubmedCount":null,"jensenScore":3206.228073,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.87163856964033,"pubTatorScore":3.31740018866786,"self":"https://pharos.nih.gov/idg/api/v1/targets(1073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/synonyms"},"_publications":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(1073)/publications"},"_namespace":null},{"id":1074,"version":2,"created":1554862182000,"modified":1554862189000,"deprecated":false,"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","accession":"P14060","gene":"HSD3B1","description":"3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.621474918455086,"antibodyCount":267,"monoclonalCount":72,"pubmedCount":null,"jensenScore":370.748747,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.755208701969554,"pubTatorScore":2.630020544684237,"self":"https://pharos.nih.gov/idg/api/v1/targets(1074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/properties"},"_links":{"count":534,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(1074)/publications"},"_namespace":null},{"id":1075,"version":2,"created":1554862190000,"modified":1554862191000,"deprecated":false,"name":"Arrestin domain-containing protein 5","accession":"A6NEK1","gene":"ARRDC5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.174496124948186,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/properties"},"_links":{"count":679,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(1075)/publications"},"_namespace":null},{"id":1076,"version":3,"created":1554862192000,"modified":1555033026000,"deprecated":false,"name":"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase","accession":"Q9UK23","gene":"NAGPA","description":"Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. 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Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.3580393160731954,"antibodyCount":394,"monoclonalCount":85,"pubmedCount":null,"jensenScore":229.463476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.57475273163292,"pubTatorScore":2.266578219979825,"self":"https://pharos.nih.gov/idg/api/v1/targets(1176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/properties"},"_links":{"count":1253,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/synonyms"},"_publications":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(1176)/publications"},"_namespace":null},{"id":1177,"version":3,"created":1554862980000,"modified":1555033137000,"deprecated":false,"name":"CCA tRNA nucleotidyltransferase 1, mitochondrial","accession":"Q96Q11","gene":"TRNT1","description":"Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.381716610823494,"antibodyCount":33,"monoclonalCount":7,"pubmedCount":null,"jensenScore":23.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.357360006346454,"pubTatorScore":0.9720999474776685,"self":"https://pharos.nih.gov/idg/api/v1/targets(1177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(1177)/publications"},"_namespace":null},{"id":1178,"version":2,"created":1554862984000,"modified":1554862987000,"deprecated":false,"name":"Paired box protein Pax-2","accession":"Q02962","gene":"PAX2","description":"Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). 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Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8357319291536378,"antibodyCount":233,"monoclonalCount":113,"pubmedCount":null,"jensenScore":76.496361,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.33086810950227,"pubTatorScore":1.7647755980037256,"self":"https://pharos.nih.gov/idg/api/v1/targets(1182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(1182)/publications"},"_namespace":null},{"id":1183,"version":2,"created":1554863000000,"modified":1554863002000,"deprecated":false,"name":"Extracellular tyrosine-protein kinase PKDCC","accession":"Q504Y2","gene":"PKDCC","description":"Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. 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May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.1595099255539152,"antibodyCount":51,"monoclonalCount":3,"pubmedCount":null,"jensenScore":16.188545,"patentCount":3622,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.829039426124186,"pubTatorScore":0.5576409584427934,"self":"https://pharos.nih.gov/idg/api/v1/targets(1183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(1183)/publications"},"_namespace":null},{"id":1184,"version":3,"created":1554863003000,"modified":1555033141000,"deprecated":false,"name":"Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase","accession":"O43173","gene":"ST8SIA3","description":"Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. 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It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.05924312590313,"antibodyCount":57,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.120137,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":28.822846920582478,"pubTatorScore":0.8507019119643774,"self":"https://pharos.nih.gov/idg/api/v1/targets(1184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/properties"},"_links":{"count":680,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(1184)/publications"},"_namespace":null},{"id":1185,"version":2,"created":1554863005000,"modified":1554863015000,"deprecated":false,"name":"Serine protease hepsin","accession":"P05981","gene":"HPN","description":"Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). 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Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.500227716062851,"antibodyCount":125,"monoclonalCount":22,"pubmedCount":null,"jensenScore":315.982718,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.53240540444839,"pubTatorScore":1.944366803706657,"self":"https://pharos.nih.gov/idg/api/v1/targets(1185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(1185)/publications"},"_namespace":null},{"id":1186,"version":3,"created":1554863016000,"modified":1555033143000,"deprecated":false,"name":"U4/U6 small nuclear ribonucleoprotein Prp4","accession":"O43172","gene":"PRPF4","description":"Participates in pre-mRNA splicing. 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Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7413028682464202,"antibodyCount":210,"monoclonalCount":125,"pubmedCount":null,"jensenScore":57.505777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":35.068155386655356,"pubTatorScore":1.5667328534088603,"self":"https://pharos.nih.gov/idg/api/v1/targets(1507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(1507)/publications"},"_namespace":null},{"id":1508,"version":3,"created":1554865763000,"modified":1555033362000,"deprecated":false,"name":"Intelectin-2","accession":"Q8WWU7","gene":"ITLN2","description":"May play a role in the defense system against pathogens.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8818801400749041,"antibodyCount":88,"monoclonalCount":4,"pubmedCount":null,"jensenScore":7.688034,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":11.645890037202406,"pubTatorScore":1.5667647455862992,"self":"https://pharos.nih.gov/idg/api/v1/targets(1508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/properties"},"_links":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(1508)/publications"},"_namespace":null},{"id":1509,"version":2,"created":1554865765000,"modified":1554865768000,"deprecated":false,"name":"Sperm-associated antigen 5","accession":"Q96R06","gene":"SPAG5","description":"Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7274272115070566,"antibodyCount":136,"monoclonalCount":23,"pubmedCount":null,"jensenScore":51.399863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.86370395045702,"pubTatorScore":1.528947279700076,"self":"https://pharos.nih.gov/idg/api/v1/targets(1509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(1509)/publications"},"_namespace":null},{"id":1510,"version":3,"created":1554865768000,"modified":1555033363000,"deprecated":false,"name":"Cbp/p300-interacting transactivator 2","accession":"Q99967","gene":"CITED2","description":"Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.077598957112513,"antibodyCount":167,"monoclonalCount":23,"pubmedCount":null,"jensenScore":134.770186,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":47.57652001359431,"pubTatorScore":1.7429530643034703,"self":"https://pharos.nih.gov/idg/api/v1/targets(1510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(1510)/publications"},"_namespace":null},{"id":1511,"version":3,"created":1554865773000,"modified":1555033364000,"deprecated":false,"name":"CST complex subunit TEN1","accession":"Q86WV5","gene":"TEN1","description":"Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1818176700234755,"antibodyCount":8,"monoclonalCount":1,"pubmedCount":null,"jensenScore":142.00577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":23.43799046602949,"pubTatorScore":1.8735535525615976,"self":"https://pharos.nih.gov/idg/api/v1/targets(1511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(1511)/publications"},"_namespace":null},{"id":1512,"version":2,"created":1554865775000,"modified":1554865775000,"deprecated":false,"name":"Putative zinc finger protein 840","accession":"A6NDX5","gene":"ZNF840P","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.5821605842651665,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1512)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(1512)/publications"},"_namespace":null},{"id":1513,"version":2,"created":1554865775000,"modified":1554865778000,"deprecated":false,"name":"UDP-N-acetylhexosamine pyrophosphorylase-like protein 1","accession":"Q3KQV9","gene":"UAP1L1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":70,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.814584628465838,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(1513)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(1513)/publications"},"_namespace":null},{"id":1514,"version":3,"created":1554865778000,"modified":1555033366000,"deprecated":false,"name":"REM2- and Rab-like small GTPase 1","accession":"Q9BU20","gene":"RSG1","description":"Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.3292525852599708,"antibodyCount":31,"monoclonalCount":10,"pubmedCount":null,"jensenScore":22.174481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.464783687543033,"pubTatorScore":0.9879427492076456,"self":"https://pharos.nih.gov/idg/api/v1/targets(1514)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(1514)/publications"},"_namespace":null},{"id":1515,"version":3,"created":1554865781000,"modified":1555033368000,"deprecated":false,"name":"Src kinase-associated phosphoprotein 1","accession":"Q86WV1","gene":"SKAP1","description":"Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3152731882143351,"antibodyCount":175,"monoclonalCount":34,"pubmedCount":null,"jensenScore":25.178416,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":49,"knowledgeAvailability":32.57898703245089,"pubTatorScore":1.3528930792475478,"self":"https://pharos.nih.gov/idg/api/v1/targets(1515)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(1515)/publications"},"_namespace":null},{"id":1516,"version":2,"created":1554865784000,"modified":1554865786000,"deprecated":false,"name":"Lipase maturation factor 2","accession":"Q9BU23","gene":"LMF2","description":"Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.2218487496163564,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.895238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.928839689302183,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(1516)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1516)/publications"},"_namespace":null},{"id":1517,"version":2,"created":1554865787000,"modified":1554865790000,"deprecated":false,"name":"Hairy/enhancer-of-split related with YRPW motif protein 1","accession":"Q9Y5J3","gene":"HEY1","description":"Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2839782827565593,"antibodyCount":335,"monoclonalCount":215,"pubmedCount":null,"jensenScore":163.387144,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.75704237386846,"pubTatorScore":2.1845728579159287,"self":"https://pharos.nih.gov/idg/api/v1/targets(1517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(1517)/publications"},"_namespace":null},{"id":1518,"version":2,"created":1554865790000,"modified":1554865793000,"deprecated":false,"name":"Calbindin","accession":"P05937","gene":"CALB1","description":"Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.319564764438253,"antibodyCount":287,"monoclonalCount":63,"pubmedCount":null,"jensenScore":2149.899918,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.17439596731848,"pubTatorScore":2.185615613250135,"self":"https://pharos.nih.gov/idg/api/v1/targets(1518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(1518)/publications"},"_namespace":null},{"id":1519,"version":2,"created":1554865794000,"modified":1554865796000,"deprecated":false,"name":"Pleckstrin homology-like domain family A member 3","accession":"Q9Y5J5","gene":"PHLDA3","description":"p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. 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Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. 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Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). 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Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8646529587057563,"antibodyCount":34,"monoclonalCount":1,"pubmedCount":null,"jensenScore":69.531214,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.944479381616944,"pubTatorScore":1.8458262497457494,"self":"https://pharos.nih.gov/idg/api/v1/targets(1601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(1601)/publications"},"_namespace":null},{"id":1602,"version":3,"created":1554866047000,"modified":1555033427000,"deprecated":false,"name":"Sialidase-4","accession":"Q8WWR8","gene":"NEU4","description":"May function in lysosomal catabolism of sialylated glycoconjugates. 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Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.3962404697813218,"antibodyCount":115,"monoclonalCount":0,"pubmedCount":null,"jensenScore":25.106124,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":24.243851462563175,"pubTatorScore":1.2978220518458632,"self":"https://pharos.nih.gov/idg/api/v1/targets(1602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(1602)/publications"},"_namespace":null},{"id":1603,"version":2,"created":1554866051000,"modified":1554866052000,"deprecated":false,"name":"Opiorphin prepropeptide","accession":"Q99935","gene":"OPRPN","description":"Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. 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Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5025174626326296,"antibodyCount":394,"monoclonalCount":80,"pubmedCount":null,"jensenScore":335.071387,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.455514125649835,"pubTatorScore":2.3654156744559964,"self":"https://pharos.nih.gov/idg/api/v1/targets(1605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":512,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/properties"},"_links":{"count":1189,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(1605)/publications"},"_namespace":null},{"id":1606,"version":2,"created":1554866061000,"modified":1554866063000,"deprecated":false,"name":"Ras-related protein Rab-39A","accession":"Q14964","gene":"RAB39A","description":"Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. 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The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9018666536966495,"antibodyCount":281,"monoclonalCount":50,"pubmedCount":null,"jensenScore":84.509388,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":46.3480326011813,"pubTatorScore":2.134983651676906,"self":"https://pharos.nih.gov/idg/api/v1/targets(1666)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":564,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/properties"},"_links":{"count":1129,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/synonyms"},"_publications":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(1666)/publications"},"_namespace":null},{"id":1667,"version":2,"created":1554866385000,"modified":1554866391000,"deprecated":false,"name":"Transient receptor potential cation channel subfamily M member 2","accession":"O94759","gene":"TRPM2","description":"Isoform 3: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.3431812562907204,"antibodyCount":209,"monoclonalCount":2,"pubmedCount":null,"jensenScore":25.136394,"patentCount":17620,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.32165052899715,"pubTatorScore":2.2813679747644464,"self":"https://pharos.nih.gov/idg/api/v1/targets(1667)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(1667)/publications"},"_namespace":null},{"id":1668,"version":3,"created":1554866392000,"modified":1555033482000,"deprecated":false,"name":"Opioid-binding protein/cell adhesion molecule","accession":"Q14982","gene":"OPCML","description":"Binds opioids in the presence of acidic lipids; probably involved in cell contact.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6591449871542372,"antibodyCount":163,"monoclonalCount":4,"pubmedCount":null,"jensenScore":52.217845,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.30984320765463,"pubTatorScore":1.6459029107299965,"self":"https://pharos.nih.gov/idg/api/v1/targets(1668)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(1668)/publications"},"_namespace":null},{"id":1669,"version":3,"created":1554866395000,"modified":1555033483000,"deprecated":false,"name":"Interleukin-10 receptor subunit alpha","accession":"Q13651","gene":"IL10RA","description":"Receptor for IL10; binds IL10 with a high affinity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0822194018828557,"antibodyCount":599,"monoclonalCount":285,"pubmedCount":null,"jensenScore":94.930674,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.86502916142436,"pubTatorScore":2.1407042325740395,"self":"https://pharos.nih.gov/idg/api/v1/targets(1669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(1669)/publications"},"_namespace":null},{"id":1670,"version":2,"created":1554866399000,"modified":1554866399000,"deprecated":false,"name":"Putative uncharacterized protein SHANK2-AS3","accession":"Q9BTD1","gene":"SHANK2-AS3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.117805997054004,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/links"},"_synonyms":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(1670)/publications"},"_namespace":null},{"id":1671,"version":2,"created":1554866399000,"modified":1554866403000,"deprecated":false,"name":"Nuclear mitotic apparatus protein 1","accession":"Q14980","gene":"NUMA1","description":"Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.765437163511179,"antibodyCount":235,"monoclonalCount":56,"pubmedCount":null,"jensenScore":575.768376,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.44427868551381,"pubTatorScore":2.643643026504928,"self":"https://pharos.nih.gov/idg/api/v1/targets(1671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":599,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/properties"},"_links":{"count":1289,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/synonyms"},"_publications":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(1671)/publications"},"_namespace":null},{"id":1672,"version":2,"created":1554866404000,"modified":1554866407000,"deprecated":false,"name":"Unconventional prefoldin RPB5 interactor 1","accession":"O94763","gene":"URI1","description":"Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.154092445493425,"antibodyCount":150,"monoclonalCount":16,"pubmedCount":null,"jensenScore":134.791463,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.96142243072948,"pubTatorScore":1.2803289891664442,"self":"https://pharos.nih.gov/idg/api/v1/targets(1672)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(1672)/publications"},"_namespace":null},{"id":1673,"version":2,"created":1554866408000,"modified":1554866410000,"deprecated":false,"name":"Gasdermin-A","accession":"Q96QA5","gene":"GSDMA","description":"May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4440059578306288,"antibodyCount":77,"monoclonalCount":1,"pubmedCount":null,"jensenScore":26.68852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.98311739648423,"pubTatorScore":0.8766438984987317,"self":"https://pharos.nih.gov/idg/api/v1/targets(1673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(1673)/publications"},"_namespace":null},{"id":1674,"version":3,"created":1554866411000,"modified":1555033484000,"deprecated":false,"name":"Nuclear cap-binding protein subunit 2","accession":"P52298","gene":"NCBP2","description":"Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4509879049559327,"antibodyCount":110,"monoclonalCount":16,"pubmedCount":null,"jensenScore":24.215146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.374749820387784,"pubTatorScore":1.4098794500040757,"self":"https://pharos.nih.gov/idg/api/v1/targets(1674)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(1674)/publications"},"_namespace":null},{"id":1675,"version":2,"created":1554866414000,"modified":1554866417000,"deprecated":false,"name":"ATP-dependent DNA helicase Q4","accession":"O94761","gene":"RECQL4","description":"DNA-dependent ATPase. May modulate chromosome segregation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.559291830879104,"pubTatorScore":2.1315063555170557,"self":"https://pharos.nih.gov/idg/api/v1/targets(1675)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/properties"},"_links":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(1675)/publications"},"_namespace":null},{"id":1676,"version":2,"created":1554866417000,"modified":1554866420000,"deprecated":false,"name":"ATP-dependent DNA helicase Q5","accession":"O94762","gene":"RECQL5","description":"Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6737272392684617,"antibodyCount":148,"monoclonalCount":3,"pubmedCount":null,"jensenScore":56.213067,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.25735231303438,"pubTatorScore":1.702072155989254,"self":"https://pharos.nih.gov/idg/api/v1/targets(1676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(1676)/publications"},"_namespace":null},{"id":1677,"version":3,"created":1554866421000,"modified":1555033486000,"deprecated":false,"name":"Serine/threonine-protein kinase 17B","accession":"O94768","gene":"STK17B","description":"Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.2692278149360092,"antibodyCount":344,"monoclonalCount":29,"pubmedCount":null,"jensenScore":26.593893,"patentCount":3914,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.78907398232207,"pubTatorScore":1.1890399805288363,"self":"https://pharos.nih.gov/idg/api/v1/targets(1677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(1677)/publications"},"_namespace":null},{"id":1678,"version":3,"created":1554866428000,"modified":1555033487000,"deprecated":false,"name":"Importin subunit alpha-5","accession":"P52294","gene":"KPNA1","description":"Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9509188792196084,"antibodyCount":284,"monoclonalCount":61,"pubmedCount":null,"jensenScore":85.30549,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.92514477718884,"pubTatorScore":1.8022111240896899,"self":"https://pharos.nih.gov/idg/api/v1/targets(1678)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":494,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/properties"},"_links":{"count":1135,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(1678)/publications"},"_namespace":null},{"id":1679,"version":2,"created":1554866433000,"modified":1554866435000,"deprecated":false,"name":"Pro-neuregulin-4, membrane-bound isoform","accession":"Q8WWG1","gene":"NRG4","description":"Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. 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Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.8885341684905472,"antibodyCount":271,"monoclonalCount":7,"pubmedCount":null,"jensenScore":73.305966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":46.47741139574961,"pubTatorScore":1.782535169534217,"self":"https://pharos.nih.gov/idg/api/v1/targets(1753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(1753)/publications"},"_namespace":null},{"id":1754,"version":3,"created":1554867369000,"modified":1555033543000,"deprecated":false,"name":"CCAAT/enhancer-binding protein gamma","accession":"P53567","gene":"CEBPG","description":"Transcription factor that binds to the promoter and the enhancer regions of target genes. 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Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6446026982283284,"antibodyCount":288,"monoclonalCount":30,"pubmedCount":null,"jensenScore":44.909003,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.50773135346582,"pubTatorScore":1.5878178197368258,"self":"https://pharos.nih.gov/idg/api/v1/targets(1757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(1757)/publications"},"_namespace":null},{"id":1758,"version":3,"created":1554867378000,"modified":1555033547000,"deprecated":false,"name":"Dickkopf-like protein 1","accession":"Q9UK85","gene":"DKKL1","description":"Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. 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M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also involved in haematopoietic stem cells specification: acts by binding to m6A-containing mRNAs, leading to decrease Notch dignaling and promote endothelial to haematopoietic transition (By similarity). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.379291824010017,"antibodyCount":88,"monoclonalCount":1,"pubmedCount":null,"jensenScore":18.02342,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.718264373428546,"pubTatorScore":1.0443903969872081,"self":"https://pharos.nih.gov/idg/api/v1/targets(1760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(1760)/publications"},"_namespace":null},{"id":1761,"version":3,"created":1554867385000,"modified":1555033548000,"deprecated":false,"name":"DNA (cytosine-5)-methyltransferase 3-like","accession":"Q9UJW3","gene":"DNMT3L","description":"Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). 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While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.955550008303641,"antibodyCount":403,"monoclonalCount":104,"pubmedCount":null,"jensenScore":87.16905,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.831556841143634,"pubTatorScore":1.763790545473362,"self":"https://pharos.nih.gov/idg/api/v1/targets(1761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/properties"},"_links":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(1761)/publications"},"_namespace":null},{"id":1762,"version":3,"created":1554867387000,"modified":1555033550000,"deprecated":false,"name":"Tubulointerstitial nephritis antigen","accession":"Q9UJW2","gene":"TINAG","description":"Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. 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Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0845632275812305,"antibodyCount":103,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1172.785159,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.35503458029925,"pubTatorScore":2.283008510599602,"self":"https://pharos.nih.gov/idg/api/v1/targets(1895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/properties"},"_links":{"count":1141,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(1895)/publications"},"_namespace":null},{"id":1896,"version":2,"created":1554868175000,"modified":1554868176000,"deprecated":false,"name":"Serpin B12","accession":"Q96P63","gene":"SERPINB12","description":"Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5662410275720295,"antibodyCount":155,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.274038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.545477131162176,"pubTatorScore":0.3937839653827023,"self":"https://pharos.nih.gov/idg/api/v1/targets(1896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/properties"},"_links":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(1896)/publications"},"_namespace":null},{"id":1897,"version":2,"created":1554868176000,"modified":1554868180000,"deprecated":false,"name":"Desmin","accession":"P17661","gene":"DES","description":"Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5606845203649036,"antibodyCount":991,"monoclonalCount":388,"pubmedCount":null,"jensenScore":36.649415,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.35528068136759,"pubTatorScore":3.3294745230310103,"self":"https://pharos.nih.gov/idg/api/v1/targets(1897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/properties"},"_links":{"count":1122,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(1897)/publications"},"_namespace":null},{"id":1898,"version":2,"created":1554868181000,"modified":1554868182000,"deprecated":false,"name":"Zona pellucida-binding protein 1","accession":"Q9BS86","gene":"ZPBP","description":"Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.4404107771381454,"antibodyCount":43,"monoclonalCount":4,"pubmedCount":null,"jensenScore":27.125969,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.19633908405359,"pubTatorScore":0.18225169009695621,"self":"https://pharos.nih.gov/idg/api/v1/targets(1898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/properties"},"_links":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1898)/publications"},"_namespace":null},{"id":1899,"version":2,"created":1554868183000,"modified":1554868184000,"deprecated":false,"name":"Shadow of prion protein","accession":"Q5BIV9","gene":"SPRN","description":"Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.496975112399225,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":315.102369,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.954515739352754,"pubTatorScore":1.4110582111071686,"self":"https://pharos.nih.gov/idg/api/v1/targets(1899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/properties"},"_links":{"count":724,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1899)/publications"},"_namespace":null},{"id":1900,"version":3,"created":1554868185000,"modified":1555033635000,"deprecated":false,"name":"5'-AMP-activated protein kinase catalytic subunit alpha-2","accession":"P54646","gene":"PRKAA2","description":"Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.4270543185885953,"antibodyCount":603,"monoclonalCount":90,"pubmedCount":null,"jensenScore":21.129602,"patentCount":2708,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":48.25519974994137,"pubTatorScore":2.891633918314638,"self":"https://pharos.nih.gov/idg/api/v1/targets(1900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":611,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/properties"},"_links":{"count":1080,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/synonyms"},"_publications":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(1900)/publications"},"_namespace":null},{"id":1901,"version":3,"created":1554868189000,"modified":1554868312000,"deprecated":false,"name":"Non-lysosomal glucosylceramidase","accession":"Q9HCG7","gene":"GBA2","description":"Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.623300071077421,"antibodyCount":59,"monoclonalCount":3,"pubmedCount":null,"jensenScore":43.136831,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.89649267724086,"pubTatorScore":1.3540404840396234,"self":"https://pharos.nih.gov/idg/api/v1/targets(1901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(1901)/publications"},"_namespace":null},{"id":1902,"version":2,"created":1554868313000,"modified":1554868316000,"deprecated":false,"name":"Zinc finger protein 160","accession":"Q9HCG1","gene":"ZNF160","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.6726109010774758,"antibodyCount":63,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.330555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.951730359231558,"pubTatorScore":0.7552394067648586,"self":"https://pharos.nih.gov/idg/api/v1/targets(1902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1902)/publications"},"_namespace":null},{"id":1903,"version":4,"created":1554868316000,"modified":1555033639000,"deprecated":false,"name":"Calpain-2 catalytic subunit","accession":"P17655","gene":"CAPN2","description":"Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.6958534248572399,"antibodyCount":220,"monoclonalCount":53,"pubmedCount":null,"jensenScore":48.462233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":50.06881370779312,"pubTatorScore":2.38354695187271,"self":"https://pharos.nih.gov/idg/api/v1/targets(1903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":479,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/properties"},"_links":{"count":1308,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(1903)/publications"},"_namespace":null},{"id":1904,"version":3,"created":1554868368000,"modified":1555033642000,"deprecated":false,"name":"Cytoplasmic protein NCK1","accession":"P16333","gene":"NCK1","description":"Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.250320872878768,"antibodyCount":398,"monoclonalCount":108,"pubmedCount":null,"jensenScore":186.504647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":43.22202645658912,"pubTatorScore":2.104460373381725,"self":"https://pharos.nih.gov/idg/api/v1/targets(1904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":654,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/properties"},"_links":{"count":1167,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/synonyms"},"_publications":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(1904)/publications"},"_namespace":null},{"id":1905,"version":3,"created":1554868373000,"modified":1555033644000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 6","accession":"P17658","gene":"KCNA6","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.6067488398587335,"antibodyCount":86,"monoclonalCount":11,"pubmedCount":null,"jensenScore":36.750194,"patentCount":1758,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":30.935589263743452,"pubTatorScore":1.3313188207116937,"self":"https://pharos.nih.gov/idg/api/v1/targets(1905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/properties"},"_links":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1905)/publications"},"_namespace":null},{"id":1906,"version":3,"created":1554868374000,"modified":1555033645000,"deprecated":false,"name":"WD repeat and FYVE domain-containing protein 2","accession":"Q96P53","gene":"WDFY2","description":"Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). 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Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5809701363981112,"antibodyCount":145,"monoclonalCount":2,"pubmedCount":null,"jensenScore":42.84336,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.08245698627497,"pubTatorScore":1.3853160214461315,"self":"https://pharos.nih.gov/idg/api/v1/targets(1910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(1910)/publications"},"_namespace":null},{"id":1911,"version":2,"created":1554868391000,"modified":1554868393000,"deprecated":false,"name":"MAGE-like protein 2","accession":"Q9UJ55","gene":"MAGEL2","description":"Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. 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PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. 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PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0725141484662384,"antibodyCount":293,"monoclonalCount":5,"pubmedCount":null,"jensenScore":114.434802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.12082519181108,"pubTatorScore":1.4844966654107528,"self":"https://pharos.nih.gov/idg/api/v1/targets(1919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(1919)/publications"},"_namespace":null},{"id":1920,"version":3,"created":1554868430000,"modified":1555033655000,"deprecated":false,"name":"Nuclear receptor subfamily 2 group E member 1","accession":"Q9Y466","gene":"NR2E1","description":"Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). 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Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7501937867821071,"antibodyCount":191,"monoclonalCount":138,"pubmedCount":null,"jensenScore":5.585444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.12953073623382,"pubTatorScore":0.3603263937362369,"self":"https://pharos.nih.gov/idg/api/v1/targets(1921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(1921)/publications"},"_namespace":null},{"id":1922,"version":3,"created":1554868435000,"modified":1555033656000,"deprecated":false,"name":"Elongation factor 1-delta","accession":"P29692","gene":"EEF1D","description":"Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4920389392750326,"antibodyCount":198,"monoclonalCount":16,"pubmedCount":null,"jensenScore":29.454816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":48.59641613646232,"pubTatorScore":1.554675836219506,"self":"https://pharos.nih.gov/idg/api/v1/targets(1922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(1922)/publications"},"_namespace":null},{"id":1923,"version":3,"created":1554868440000,"modified":1555033659000,"deprecated":false,"name":"Kinesin-like protein KIF22","accession":"Q14807","gene":"KIF22","description":"Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. 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Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6999615439352413,"antibodyCount":147,"monoclonalCount":60,"pubmedCount":null,"jensenScore":54.308317,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":45.4057832987793,"pubTatorScore":1.8641204972809182,"self":"https://pharos.nih.gov/idg/api/v1/targets(1923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/properties"},"_links":{"count":1180,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(1923)/publications"},"_namespace":null},{"id":1924,"version":2,"created":1554868444000,"modified":1554868447000,"deprecated":false,"name":"Homeobox protein MSX-1","accession":"P28360","gene":"MSX1","description":"Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5924493453394435,"antibodyCount":298,"monoclonalCount":79,"pubmedCount":null,"jensenScore":390.083512,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.990639124367526,"pubTatorScore":2.3705051364039837,"self":"https://pharos.nih.gov/idg/api/v1/targets(1924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/synonyms"},"_publications":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(1924)/publications"},"_namespace":null},{"id":1925,"version":3,"created":1554868448000,"modified":1555033660000,"deprecated":false,"name":"PHD finger protein 11","accession":"Q9UIL8","gene":"PHF11","description":"Positive regulator of Th1-type cytokine gene expression.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.1372747950743574,"antibodyCount":126,"monoclonalCount":7,"pubmedCount":null,"jensenScore":16.997296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.008292910844816,"pubTatorScore":1.5988993621042322,"self":"https://pharos.nih.gov/idg/api/v1/targets(1925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(1925)/publications"},"_namespace":null},{"id":1926,"version":3,"created":1554868451000,"modified":1555033662000,"deprecated":false,"name":"TBC1 domain family member 23","accession":"Q9NUY8","gene":"TBC1D23","description":"Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). 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Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6715051301219725,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.566822,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.049962351112715,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(1926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":393,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(1926)/publications"},"_namespace":null},{"id":1927,"version":2,"created":1554868454000,"modified":1554868456000,"deprecated":false,"name":"Dephospho-CoA kinase domain-containing 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histocompatibility antigen, B-35 alpha chain","accession":"P30685","gene":"HLA-B","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8875247029897861,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1613.472112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.7801564385417628,"self":"https://pharos.nih.gov/idg/api/v1/targets(1928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1938,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/properties"},"_links":{"count":1511,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/links"},"_synonyms":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/synonyms"},"_publications":{"count":1770,"href":"https://pharos.nih.gov/idg/api/v1/targets(1928)/publications"},"_namespace":null},{"id":1929,"version":2,"created":1554868471000,"modified":1554868475000,"deprecated":false,"name":"40S ribosomal protein 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1","accession":"Q9HCN8","gene":"SDF2L1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5714542143758434,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.345171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.85386265611153,"pubTatorScore":0.3084626038558672,"self":"https://pharos.nih.gov/idg/api/v1/targets(1930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(1930)/publications"},"_namespace":null},{"id":1931,"version":2,"created":1554868480000,"modified":1554868484000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 2","accession":"P16389","gene":"KCNA2","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.5555023992097845,"antibodyCount":205,"monoclonalCount":29,"pubmedCount":null,"jensenScore":343.284659,"patentCount":41091,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.70590595579717,"pubTatorScore":2.308098234828824,"self":"https://pharos.nih.gov/idg/api/v1/targets(1931)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(1931)/publications"},"_namespace":null},{"id":1932,"version":4,"created":1554868485000,"modified":1555033668000,"deprecated":false,"name":"Serine/threonine-protein kinase B-raf","accession":"P15056","gene":"BRAF","description":"Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.3358160611629932,"antibodyCount":1431,"monoclonalCount":423,"pubmedCount":null,"jensenScore":220.931088,"patentCount":172202,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":61.272893015894574,"pubTatorScore":3.6376522024060898,"self":"https://pharos.nih.gov/idg/api/v1/targets(1932)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2494,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/properties"},"_links":{"count":4137,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/links"},"_synonyms":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/synonyms"},"_publications":{"count":1873,"href":"https://pharos.nih.gov/idg/api/v1/targets(1932)/publications"},"_namespace":null},{"id":1933,"version":2,"created":1554868877000,"modified":1554868879000,"deprecated":false,"name":"Spermidine/spermine N(1)-acetyltransferase-like protein 1","accession":"Q86VE3","gene":"SATL1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.395749513234078,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(1933)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/properties"},"_links":{"count":700,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(1933)/publications"},"_namespace":null},{"id":1934,"version":3,"created":1554868879000,"modified":1555033682000,"deprecated":false,"name":"GPN-loop GTPase 1","accession":"Q9HCN4","gene":"GPN1","description":"Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0513669594211132,"antibodyCount":136,"monoclonalCount":39,"pubmedCount":null,"jensenScore":11.296713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":37.65424320519641,"pubTatorScore":1.0498637880278818,"self":"https://pharos.nih.gov/idg/api/v1/targets(1934)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(1934)/publications"},"_namespace":null},{"id":1935,"version":3,"created":1554868882000,"modified":1555033683000,"deprecated":false,"name":"Myb-related transcription factor, partner of profilin","accession":"Q86VE0","gene":"MYPOP","description":"Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.17609125905568124,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.533333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":25.964559326189466,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(1935)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/properties"},"_links":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(1935)/publications"},"_namespace":null},{"id":1936,"version":2,"created":1554868884000,"modified":1554868887000,"deprecated":false,"name":"Post-GPI attachment to proteins factor 6","accession":"Q9HCN3","gene":"TMEM8A","description":"Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5682017245012895,"antibodyCount":16,"monoclonalCount":7,"pubmedCount":null,"jensenScore":3.554278,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.12404262197576,"pubTatorScore":0.985276713227949,"self":"https://pharos.nih.gov/idg/api/v1/targets(1936)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(1936)/publications"},"_namespace":null},{"id":1937,"version":3,"created":1554868888000,"modified":1555033685000,"deprecated":false,"name":"GC-rich sequence DNA-binding factor 2","accession":"P16383","gene":"GCFC2","description":"Factor that represses transcription. 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