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May contribute to cancer pathogenesis by promoting tumor cell migration.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.606999849775019,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.568854,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":31.780429467567895,"pubTatorScore":1.2436285357410788,"self":"https://pharos.nih.gov/idg/api/v1/targets(18203)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(18203)/publications"},"_namespace":null},{"id":18204,"version":2,"created":1555009835000,"modified":1555009862000,"deprecated":false,"name":"Tyrosine-protein kinase receptor UFO","accession":"P30530","gene":"AXL","description":"(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.699691532209938,"antibodyCount":756,"monoclonalCount":198,"pubmedCount":null,"jensenScore":528.131087,"patentCount":74117,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.71998517470335,"pubTatorScore":2.717148052096508,"self":"https://pharos.nih.gov/idg/api/v1/targets(18204)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/properties"},"_links":{"count":1242,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/synonyms"},"_publications":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(18204)/publications"},"_namespace":null},{"id":18205,"version":3,"created":1555009863000,"modified":1555044515000,"deprecated":false,"name":"Sodium- and chloride-dependent GABA transporter 1","accession":"P30531","gene":"SLC6A1","description":"Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.","idgFamily":"Transporter","idgTDL":"Tclin","novelty":-2.9100984194244015,"antibodyCount":172,"monoclonalCount":3,"pubmedCount":null,"jensenScore":786.693194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":36.4932010713642,"pubTatorScore":2.284965448565487,"self":"https://pharos.nih.gov/idg/api/v1/targets(18205)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(18205)/publications"},"_namespace":null},{"id":18206,"version":3,"created":1555009893000,"modified":1555044517000,"deprecated":false,"name":"Heme-binding protein 1","accession":"Q9NRV9","gene":"HEBP1","description":"May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.027912464053539,"antibodyCount":132,"monoclonalCount":4,"pubmedCount":null,"jensenScore":107.488237,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.52123605005585,"pubTatorScore":2.4017299935996554,"self":"https://pharos.nih.gov/idg/api/v1/targets(18206)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(18206)/publications"},"_namespace":null},{"id":18207,"version":3,"created":1555009898000,"modified":1555044518000,"deprecated":false,"name":"Neuronal acetylcholine receptor subunit alpha-5","accession":"P30532","gene":"CHRNA5","description":"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.1557453095945154,"antibodyCount":237,"monoclonalCount":14,"pubmedCount":null,"jensenScore":143.069778,"patentCount":2140,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.57817555643266,"pubTatorScore":2.1689731142671036,"self":"https://pharos.nih.gov/idg/api/v1/targets(18207)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":497,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/synonyms"},"_publications":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(18207)/publications"},"_namespace":null},{"id":18208,"version":2,"created":1555009906000,"modified":1555009911000,"deprecated":false,"name":"Apolipoprotein L domain-containing protein 1","accession":"Q96LR9","gene":"APOLD1","description":"May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":64,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.08119898627755,"pubTatorScore":1.2428311759823414,"self":"https://pharos.nih.gov/idg/api/v1/targets(18208)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(18208)/publications"},"_namespace":null},{"id":18209,"version":2,"created":1555009912000,"modified":1555009917000,"deprecated":false,"name":"AT-rich interactive domain-containing protein 2","accession":"Q68CP9","gene":"ARID2","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.324901944178325,"antibodyCount":71,"monoclonalCount":24,"pubmedCount":null,"jensenScore":22.02128,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.82119772235735,"pubTatorScore":2.3486617259288165,"self":"https://pharos.nih.gov/idg/api/v1/targets(18209)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(18209)/publications"},"_namespace":null},{"id":18210,"version":3,"created":1555009918000,"modified":1555044520000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 E2","accession":"Q96LR5","gene":"UBE2E2","description":"Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.417444639671184,"antibodyCount":130,"monoclonalCount":10,"pubmedCount":null,"jensenScore":21.840982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.62071125756205,"pubTatorScore":1.1808333076837243,"self":"https://pharos.nih.gov/idg/api/v1/targets(18210)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(18210)/publications"},"_namespace":null},{"id":18211,"version":2,"created":1555009924000,"modified":1555009925000,"deprecated":false,"name":"Uncharacterized protein C3orf30","accession":"Q96M34","gene":"C3orf30","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(18211)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/properties"},"_links":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(18211)/publications"},"_namespace":null},{"id":18212,"version":3,"created":1555009926000,"modified":1555044523000,"deprecated":false,"name":"Protein FAM19A4","accession":"Q96LR4","gene":"FAM19A4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0574950014469144,"antibodyCount":57,"monoclonalCount":18,"pubmedCount":null,"jensenScore":9.336642,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":50,"knowledgeAvailability":18.719699279479414,"pubTatorScore":0.8709571319039024,"self":"https://pharos.nih.gov/idg/api/v1/targets(18212)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/properties"},"_links":{"count":489,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(18212)/publications"},"_namespace":null},{"id":18213,"version":3,"created":1555009929000,"modified":1555044524000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RING2","accession":"Q99496","gene":"RNF2","description":"E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0452491810528186,"antibodyCount":332,"monoclonalCount":160,"pubmedCount":null,"jensenScore":115.682553,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.87390402399221,"pubTatorScore":2.2729835941813636,"self":"https://pharos.nih.gov/idg/api/v1/targets(18213)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(18213)/publications"},"_namespace":null},{"id":18214,"version":3,"created":1555009934000,"modified":1555044525000,"deprecated":false,"name":"Uncharacterized protein C2orf50","accession":"Q96LR7","gene":"C2orf50","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18214)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/properties"},"_links":{"count":648,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(18214)/publications"},"_namespace":null},{"id":18215,"version":2,"created":1555009937000,"modified":1555009942000,"deprecated":false,"name":"Protein/nucleic acid deglycase DJ-1","accession":"Q99497","gene":"PARK7","description":"Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity (PubMed:22523093). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785, PubMed:26995087). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.892613634046932,"antibodyCount":625,"monoclonalCount":111,"pubmedCount":null,"jensenScore":835.460014,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.309912432192384,"pubTatorScore":2.7642441774915003,"self":"https://pharos.nih.gov/idg/api/v1/targets(18215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/properties"},"_links":{"count":1516,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/links"},"_synonyms":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/synonyms"},"_publications":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(18215)/publications"},"_namespace":null},{"id":18216,"version":2,"created":1555009945000,"modified":1555009956000,"deprecated":false,"name":"Protein S100-B","accession":"P04271","gene":"S100B","description":"Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.488932542289977,"antibodyCount":903,"monoclonalCount":518,"pubmedCount":null,"jensenScore":3193.151212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.417841114860174,"pubTatorScore":3.728039669647618,"self":"https://pharos.nih.gov/idg/api/v1/targets(18216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/synonyms"},"_publications":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(18216)/publications"},"_namespace":null},{"id":18217,"version":2,"created":1555009959000,"modified":1555009962000,"deprecated":false,"name":"Protein SPT2 homolog","accession":"Q68D10","gene":"SPTY2D1","description":"Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). 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Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. 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In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(18260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2679,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/properties"},"_links":{"count":1110,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/synonyms"},"_publications":{"count":2540,"href":"https://pharos.nih.gov/idg/api/v1/targets(18260)/publications"},"_namespace":null},{"id":18261,"version":2,"created":1555010333000,"modified":1555010336000,"deprecated":false,"name":"Stress-associated endoplasmic reticulum protein 2","accession":"Q8N6R1","gene":"SERP2","description":"May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. 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Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.7284836554883687,"antibodyCount":1063,"monoclonalCount":315,"pubmedCount":null,"jensenScore":9058.642958,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":3.791443935403016,"self":"https://pharos.nih.gov/idg/api/v1/targets(18263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2451,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/properties"},"_links":{"count":2940,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/synonyms"},"_publications":{"count":2032,"href":"https://pharos.nih.gov/idg/api/v1/targets(18263)/publications"},"_namespace":null},{"id":18264,"version":2,"created":1555010372000,"modified":1555010376000,"deprecated":false,"name":"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4","accession":"Q9C0J1","gene":"B3GNT4","description":"Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. 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The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4095828627958213,"antibodyCount":48,"monoclonalCount":6,"pubmedCount":null,"jensenScore":276.022785,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":25.836502608472706,"pubTatorScore":0.24303804868629444,"self":"https://pharos.nih.gov/idg/api/v1/targets(18326)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/properties"},"_links":{"count":707,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(18326)/publications"},"_namespace":null},{"id":18327,"version":3,"created":1555010643000,"modified":1555044594000,"deprecated":false,"name":"Sodium channel subunit beta-2","accession":"O60939","gene":"SCN2B","description":"Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.298420618101245,"antibodyCount":156,"monoclonalCount":47,"pubmedCount":null,"jensenScore":17.129689,"patentCount":1912,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":58,"knowledgeAvailability":29.906409553429153,"pubTatorScore":1.031054582206085,"self":"https://pharos.nih.gov/idg/api/v1/targets(18327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(18327)/publications"},"_namespace":null},{"id":18328,"version":3,"created":1555010648000,"modified":1555044596000,"deprecated":false,"name":"Uncharacterized protein encoded by LINC01587","accession":"Q99440","gene":"LINC01587","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.07918124778480276,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":9.7816240844167,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(18328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(18328)/publications"},"_namespace":null},{"id":18329,"version":2,"created":1555010649000,"modified":1555010655000,"deprecated":false,"name":"Meckelin","accession":"Q5HYA8","gene":"TMEM67","description":"Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5295383493835482,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":36.32789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.0460623261669,"pubTatorScore":1.4396354100024937,"self":"https://pharos.nih.gov/idg/api/v1/targets(18329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(18329)/publications"},"_namespace":null},{"id":18330,"version":3,"created":1555010656000,"modified":1555044596000,"deprecated":false,"name":"Aldo-keto reductase family 1 member C4","accession":"P17516","gene":"AKR1C4","description":"Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). 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The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7014776807362353,"antibodyCount":221,"monoclonalCount":24,"pubmedCount":null,"jensenScore":51.386621,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.987767509545932,"pubTatorScore":2.437607501043699,"self":"https://pharos.nih.gov/idg/api/v1/targets(18330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/properties"},"_links":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(18330)/publications"},"_namespace":null},{"id":18331,"version":3,"created":1555010659000,"modified":1555044598000,"deprecated":false,"name":"Keratocan","accession":"O60938","gene":"KERA","description":"May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.227980643983189,"antibodyCount":105,"monoclonalCount":5,"pubmedCount":null,"jensenScore":161.279357,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":26.233469263490242,"pubTatorScore":1.6509209993764413,"self":"https://pharos.nih.gov/idg/api/v1/targets(18331)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/properties"},"_links":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(18331)/publications"},"_namespace":null},{"id":18332,"version":3,"created":1555010663000,"modified":1555044599000,"deprecated":false,"name":"Cyclic AMP-dependent transcription factor ATF-6 alpha","accession":"P18850","gene":"ATF6","description":"Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.6539092464103553,"antibodyCount":407,"monoclonalCount":86,"pubmedCount":null,"jensenScore":415.009105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.420857936834445,"pubTatorScore":2.3106378507772116,"self":"https://pharos.nih.gov/idg/api/v1/targets(18332)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(18332)/publications"},"_namespace":null},{"id":18333,"version":2,"created":1555010670000,"modified":1555010674000,"deprecated":false,"name":"Nucleolar protein 3","accession":"O60936","gene":"NOL3","description":"Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3220400983758633,"antibodyCount":271,"monoclonalCount":12,"pubmedCount":null,"jensenScore":197.586715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.59353569947662,"pubTatorScore":1.6359352386283572,"self":"https://pharos.nih.gov/idg/api/v1/targets(18333)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(18333)/publications"},"_namespace":null},{"id":18334,"version":3,"created":1555010675000,"modified":1555044600000,"deprecated":false,"name":"Nibrin","accession":"O60934","gene":"NBN","description":"Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. 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Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7854896804497282,"antibodyCount":197,"monoclonalCount":1,"pubmedCount":null,"jensenScore":62.435703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.75428609993083,"pubTatorScore":1.7299564283079218,"self":"https://pharos.nih.gov/idg/api/v1/targets(18701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(18701)/publications"},"_namespace":null},{"id":18702,"version":3,"created":1555013370000,"modified":1555014527000,"deprecated":false,"name":"Sodium channel protein type 9 subunit alpha","accession":"Q15858","gene":"SCN9A","description":"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.5799385805387294,"antibodyCount":327,"monoclonalCount":132,"pubmedCount":null,"jensenScore":379.245669,"patentCount":40955,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.212877968475794,"pubTatorScore":2.4968246052614376,"self":"https://pharos.nih.gov/idg/api/v1/targets(18702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/properties"},"_links":{"count":4120,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(18702)/publications"},"_namespace":null},{"id":18703,"version":2,"created":1555014535000,"modified":1555014540000,"deprecated":false,"name":"Hypermethylated in cancer 1 protein","accession":"Q14526","gene":"HIC1","description":"Transcriptional repressor. 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Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9730089860968754,"antibodyCount":199,"monoclonalCount":59,"pubmedCount":null,"jensenScore":106.971773,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.52030189083238,"pubTatorScore":1.960328155213801,"self":"https://pharos.nih.gov/idg/api/v1/targets(18703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(18703)/publications"},"_namespace":null},{"id":18704,"version":2,"created":1555014541000,"modified":1555014545000,"deprecated":false,"name":"Espin","accession":"B1AK53","gene":"ESPN","description":"Multifunctional actin-bundling protein. 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In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0142547710689915,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":100.360634,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.278437712646074,"pubTatorScore":1.414973347970818,"self":"https://pharos.nih.gov/idg/api/v1/targets(18704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(18704)/publications"},"_namespace":null},{"id":18705,"version":2,"created":1555014546000,"modified":1555014546000,"deprecated":false,"name":"Protein GVQW1","accession":"Q8N7I0","gene":"GVQW1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.517595389174526,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/properties"},"_links":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(18705)/publications"},"_namespace":null},{"id":18706,"version":2,"created":1555014546000,"modified":1555014549000,"deprecated":false,"name":"Keratin, type I cuticular Ha3-II","accession":"Q14525","gene":"KRT33B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.08218675455874577,"antibodyCount":116,"monoclonalCount":17,"pubmedCount":null,"jensenScore":1.020238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.46638037108637,"pubTatorScore":0.24783682248309327,"self":"https://pharos.nih.gov/idg/api/v1/targets(18706)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/properties"},"_links":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(18706)/publications"},"_namespace":null},{"id":18707,"version":2,"created":1555014549000,"modified":1555014552000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 23","accession":"Q86SG2","gene":"ANKRD23","description":"May be involved in the energy metabolism. 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Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.017679006901829,"antibodyCount":493,"monoclonalCount":234,"pubmedCount":null,"jensenScore":1049.914017,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":56.321459406769,"pubTatorScore":2.9068025037375302,"self":"https://pharos.nih.gov/idg/api/v1/targets(18708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/properties"},"_links":{"count":1246,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/synonyms"},"_publications":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(18708)/publications"},"_namespace":null},{"id":18709,"version":2,"created":1555014564000,"modified":1555014570000,"deprecated":false,"name":"Aquaporin-2","accession":"P41181","gene":"AQP2","description":"Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9532785776326125,"antibodyCount":394,"monoclonalCount":2,"pubmedCount":null,"jensenScore":957.656545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.63711835997627,"pubTatorScore":2.6570212485395417,"self":"https://pharos.nih.gov/idg/api/v1/targets(18709)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/synonyms"},"_publications":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(18709)/publications"},"_namespace":null},{"id":18710,"version":3,"created":1555014571000,"modified":1555014618000,"deprecated":false,"name":"Extracellular calcium-sensing receptor","accession":"P41180","gene":"CASR","description":"G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-3.221812559917414,"antibodyCount":441,"monoclonalCount":93,"pubmedCount":null,"jensenScore":1714.86889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.16744580763855,"pubTatorScore":2.9421124046747655,"self":"https://pharos.nih.gov/idg/api/v1/targets(18710)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/synonyms"},"_publications":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(18710)/publications"},"_namespace":null},{"id":18711,"version":3,"created":1555014620000,"modified":1555044802000,"deprecated":false,"name":"Lysozyme g-like protein 2","accession":"Q86SG7","gene":"LYG2","description":"May act as a potent antibacterial protein that may play a role in the innate immunity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7243113303243157,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.868066,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":11.984503717849064,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(18711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/properties"},"_links":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(18711)/publications"},"_namespace":null},{"id":18712,"version":2,"created":1555014622000,"modified":1555014626000,"deprecated":false,"name":"Serine/threonine-protein kinase Nek8","accession":"Q86SG6","gene":"NEK8","description":"Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.7153599528226902,"antibodyCount":225,"monoclonalCount":2,"pubmedCount":null,"jensenScore":50.895025,"patentCount":2833,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.065117638755765,"pubTatorScore":1.4435917686635487,"self":"https://pharos.nih.gov/idg/api/v1/targets(18712)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(18712)/publications"},"_namespace":null},{"id":18713,"version":2,"created":1555014626000,"modified":1555014629000,"deprecated":false,"name":"Protein S100-A7A","accession":"Q86SG5","gene":"S100A7A","description":"May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.550592405069908,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.377182,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.906574991773041,"pubTatorScore":1.150866027841494,"self":"https://pharos.nih.gov/idg/api/v1/targets(18713)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/properties"},"_links":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(18713)/publications"},"_namespace":null},{"id":18714,"version":2,"created":1555014629000,"modified":1555014629000,"deprecated":false,"name":"Putative Dresden prostate carcinoma protein 2","accession":"Q86SG4","gene":"HMGN2P46","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.470705601759493,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(18714)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(18714)/publications"},"_namespace":null},{"id":18715,"version":2,"created":1555014629000,"modified":1555014630000,"deprecated":false,"name":"Deleted in azoospermia protein 4","accession":"Q86SG3","gene":"DAZ4","description":"RNA-binding protein that plays an essential role in spermatogenesis. 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In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). 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Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.261628568384184,"antibodyCount":396,"monoclonalCount":42,"pubmedCount":null,"jensenScore":204.776368,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.38581343697828,"pubTatorScore":2.53662591709725,"self":"https://pharos.nih.gov/idg/api/v1/targets(18799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":542,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/properties"},"_links":{"count":1161,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/links"},"_synonyms":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(18799)/publications"},"_namespace":null},{"id":18800,"version":2,"created":1555016006000,"modified":1555016007000,"deprecated":false,"name":"Cis-aconitate decarboxylase","accession":"A6NK06","gene":"ACOD1","description":"Involved in the inhibition of the inflammatory response. 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Plays a role in the embryo implantation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7927661867042421,"antibodyCount":53,"monoclonalCount":1,"pubmedCount":null,"jensenScore":60.220555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.1601731614744817,"self":"https://pharos.nih.gov/idg/api/v1/targets(18800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/properties"},"_links":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(18800)/publications"},"_namespace":null},{"id":18801,"version":2,"created":1555016007000,"modified":1555016014000,"deprecated":false,"name":"Sushi repeat-containing protein SRPX2","accession":"O60687","gene":"SRPX2","description":"Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive 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fibroblasts.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5663813716630508,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.778461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":33.0716466889752,"pubTatorScore":0.5720967291742244,"self":"https://pharos.nih.gov/idg/api/v1/targets(18803)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(18803)/publications"},"_namespace":null},{"id":18804,"version":2,"created":1555016023000,"modified":1555016025000,"deprecated":false,"name":"Inactive ubiquitin carboxyl-terminal hydrolase 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Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":121,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.608787508454643,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(18806)/publications"},"_namespace":null},{"id":18807,"version":2,"created":1555016035000,"modified":1555016039000,"deprecated":false,"name":"Inactive ubiquitin carboxyl-terminal hydrolase 54","accession":"Q70EL1","gene":"USP54","description":"Has no peptidase activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.44314440358119517,"antibodyCount":31,"monoclonalCount":15,"pubmedCount":null,"jensenScore":2.905928,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.67412746639529,"pubTatorScore":0.05115252244738129,"self":"https://pharos.nih.gov/idg/api/v1/targets(18807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(18807)/publications"},"_namespace":null},{"id":18808,"version":3,"created":1555016039000,"modified":1555044878000,"deprecated":false,"name":"Male-specific lethal 3 homolog","accession":"Q8N5Y2","gene":"MSL3","description":"May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.0844627742703725,"antibodyCount":108,"monoclonalCount":3,"pubmedCount":null,"jensenScore":10.725535,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.34277617968513,"pubTatorScore":0.8234431231813019,"self":"https://pharos.nih.gov/idg/api/v1/targets(18808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(18808)/publications"},"_namespace":null},{"id":18809,"version":3,"created":1555016045000,"modified":1555044879000,"deprecated":false,"name":"Peroxisome biogenesis factor 10","accession":"O60683","gene":"PEX10","description":"Somewhat implicated in the biogenesis of peroxisomes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.413446112536443,"antibodyCount":102,"monoclonalCount":12,"pubmedCount":null,"jensenScore":23.786626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.66822226150113,"pubTatorScore":1.2875884703286289,"self":"https://pharos.nih.gov/idg/api/v1/targets(18809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(18809)/publications"},"_namespace":null},{"id":18810,"version":2,"created":1555016052000,"modified":1555016059000,"deprecated":false,"name":"Importin subunit alpha-7","accession":"O60684","gene":"KPNA6","description":"Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8928062488395216,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.132333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.66851860552836,"pubTatorScore":0.5563025007672873,"self":"https://pharos.nih.gov/idg/api/v1/targets(18810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(18810)/publications"},"_namespace":null},{"id":18811,"version":2,"created":1555016060000,"modified":1555016063000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 45","accession":"Q70EL2","gene":"USP45","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2955671119055774,"antibodyCount":115,"monoclonalCount":9,"pubmedCount":null,"jensenScore":18.665186,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.479658573756204,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(18811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/properties"},"_links":{"count":842,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(18811)/publications"},"_namespace":null},{"id":18812,"version":2,"created":1555016064000,"modified":1555016069000,"deprecated":false,"name":"Musculin","accession":"O60682","gene":"MSC","description":"Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.184019354901649,"antibodyCount":184,"monoclonalCount":15,"pubmedCount":null,"jensenScore":156.411403,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.74587356438918,"pubTatorScore":2.149884124119838,"self":"https://pharos.nih.gov/idg/api/v1/targets(18812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(18812)/publications"},"_namespace":null},{"id":18813,"version":2,"created":1555016069000,"modified":1555016077000,"deprecated":false,"name":"CUGBP Elav-like family member 2","accession":"O95319","gene":"CELF2","description":"RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.630423123000801,"antibodyCount":171,"monoclonalCount":7,"pubmedCount":null,"jensenScore":43.067094,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.46813556981579,"pubTatorScore":1.5450536050566357,"self":"https://pharos.nih.gov/idg/api/v1/targets(18813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(18813)/publications"},"_namespace":null},{"id":18814,"version":3,"created":1555016078000,"modified":1555044881000,"deprecated":false,"name":"Mono [ADP-ribose] polymerase PARP16","accession":"Q8N5Y8","gene":"PARP16","description":"Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). 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During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.8468073079434304,"antibodyCount":212,"monoclonalCount":76,"pubmedCount":null,"jensenScore":686.800384,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.728198903204333,"pubTatorScore":2.2090988119962884,"self":"https://pharos.nih.gov/idg/api/v1/targets(18903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/properties"},"_links":{"count":684,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(18903)/publications"},"_namespace":null},{"id":18904,"version":3,"created":1555017773000,"modified":1555044917000,"deprecated":false,"name":"Interleukin-1 receptor antagonist protein","accession":"P18510","gene":"IL1RN","description":"Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.102664368609459,"antibodyCount":604,"monoclonalCount":249,"pubmedCount":null,"jensenScore":1215.745377,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.40986038077349,"pubTatorScore":3.294348130727778,"self":"https://pharos.nih.gov/idg/api/v1/targets(18904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1229,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/properties"},"_links":{"count":1435,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/links"},"_synonyms":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/synonyms"},"_publications":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(18904)/publications"},"_namespace":null},{"id":18905,"version":3,"created":1555017787000,"modified":1555044920000,"deprecated":false,"name":"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2","accession":"O95340","gene":"PAPSS2","description":"Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6398287804241152,"antibodyCount":186,"monoclonalCount":45,"pubmedCount":null,"jensenScore":42.551691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.301352712881204,"pubTatorScore":1.4139912171689335,"self":"https://pharos.nih.gov/idg/api/v1/targets(18905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(18905)/publications"},"_namespace":null},{"id":18906,"version":2,"created":1555017794000,"modified":1555017801000,"deprecated":false,"name":"NACHT, LRR and PYD domains-containing protein 1","accession":"Q9C000","gene":"NLRP1","description":"As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0355838445193775,"antibodyCount":183,"monoclonalCount":20,"pubmedCount":null,"jensenScore":116.475351,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.06307774274,"pubTatorScore":2.00871280973622,"self":"https://pharos.nih.gov/idg/api/v1/targets(18906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/properties"},"_links":{"count":1138,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/links"},"_synonyms":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/synonyms"},"_publications":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(18906)/publications"},"_namespace":null},{"id":18907,"version":2,"created":1555017802000,"modified":1555017810000,"deprecated":false,"name":"Protein arginine N-methyltransferase 3","accession":"O60678","gene":"PRMT3","description":"Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.3345748389083827,"antibodyCount":254,"monoclonalCount":23,"pubmedCount":null,"jensenScore":21.229985,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.63610078175405,"pubTatorScore":1.4462892720010456,"self":"https://pharos.nih.gov/idg/api/v1/targets(18907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(18907)/publications"},"_namespace":null},{"id":18908,"version":2,"created":1555017811000,"modified":1555017818000,"deprecated":false,"name":"Hepatocyte nuclear factor 1-alpha","accession":"P20823","gene":"HNF1A","description":"Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.874391880282467,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":680.87293,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.74951581382574,"pubTatorScore":2.8613712545485304,"self":"https://pharos.nih.gov/idg/api/v1/targets(18908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":703,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/properties"},"_links":{"count":1184,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/synonyms"},"_publications":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(18908)/publications"},"_namespace":null},{"id":18909,"version":3,"created":1555017820000,"modified":1555044923000,"deprecated":false,"name":"Cystatin-8","accession":"O60676","gene":"CST8","description":"Performs a specialized role during sperm development and maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.511704577030571,"antibodyCount":163,"monoclonalCount":2,"pubmedCount":null,"jensenScore":292.013911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":16.990382344738403,"pubTatorScore":1.7231916901939994,"self":"https://pharos.nih.gov/idg/api/v1/targets(18909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/properties"},"_links":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(18909)/publications"},"_namespace":null},{"id":18910,"version":2,"created":1555017821000,"modified":1555017827000,"deprecated":false,"name":"Bile salt-activated lipase","accession":"P19835","gene":"CEL","description":"Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.572543104520058,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":373.762661,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.22055662032748,"pubTatorScore":2.734166503390985,"self":"https://pharos.nih.gov/idg/api/v1/targets(18910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(18910)/publications"},"_namespace":null},{"id":18911,"version":3,"created":1555017828000,"modified":1555044924000,"deprecated":false,"name":"Little elongation complex subunit 2","accession":"Q659A1","gene":"ICE2","description":"Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0336470871676742,"antibodyCount":85,"monoclonalCount":3,"pubmedCount":null,"jensenScore":9.719754,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":32.40346636408697,"pubTatorScore":0.8883666552928718,"self":"https://pharos.nih.gov/idg/api/v1/targets(18911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(18911)/publications"},"_namespace":null},{"id":18912,"version":2,"created":1555017834000,"modified":1555017906000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit beta-1","accession":"P18505","gene":"GABRB1","description":"Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.3551975828347904,"antibodyCount":309,"monoclonalCount":84,"pubmedCount":null,"jensenScore":21.739697,"patentCount":1424,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.87513924504769,"pubTatorScore":1.3281132564467366,"self":"https://pharos.nih.gov/idg/api/v1/targets(18912)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/properties"},"_links":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(18912)/publications"},"_namespace":null},{"id":18913,"version":4,"created":1555017906000,"modified":1555044926000,"deprecated":false,"name":"Tyrosine-protein kinase JAK2","accession":"O60674","gene":"JAK2","description":"Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.5403663045245417,"antibodyCount":801,"monoclonalCount":85,"pubmedCount":null,"jensenScore":3339.715834,"patentCount":135858,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":68.12410647560435,"pubTatorScore":3.4702308655680247,"self":"https://pharos.nih.gov/idg/api/v1/targets(18913)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1987,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/properties"},"_links":{"count":3691,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/links"},"_synonyms":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/synonyms"},"_publications":{"count":1318,"href":"https://pharos.nih.gov/idg/api/v1/targets(18913)/publications"},"_namespace":null},{"id":18914,"version":3,"created":1555018173000,"modified":1555044935000,"deprecated":false,"name":"Transcription factor MafK","accession":"O60675","gene":"MAFK","description":"Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5562783894069772,"antibodyCount":111,"monoclonalCount":38,"pubmedCount":null,"jensenScore":33.472597,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.39374390769547,"pubTatorScore":1.2077408412967345,"self":"https://pharos.nih.gov/idg/api/v1/targets(18914)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(18914)/publications"},"_namespace":null},{"id":18915,"version":3,"created":1555018179000,"modified":1555044937000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit gamma-2","accession":"P18507","gene":"GABRG2","description":"Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.9336919686848217,"antibodyCount":298,"monoclonalCount":3,"pubmedCount":null,"jensenScore":83.054168,"patentCount":1880,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":38.018629271342704,"pubTatorScore":2.1736932021581783,"self":"https://pharos.nih.gov/idg/api/v1/targets(18915)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(18915)/publications"},"_namespace":null},{"id":18916,"version":3,"created":1555018621000,"modified":1555044939000,"deprecated":false,"name":"Ephrin-A1","accession":"P20827","gene":"EFNA1","description":"Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.0262313420045617,"antibodyCount":256,"monoclonalCount":42,"pubmedCount":null,"jensenScore":101.511553,"patentCount":38196,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.610970477704925,"pubTatorScore":2.088094500796962,"self":"https://pharos.nih.gov/idg/api/v1/targets(18916)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(18916)/publications"},"_namespace":null},{"id":18917,"version":3,"created":1555018629000,"modified":1555044940000,"deprecated":false,"name":"Nuclear factor NF-kappa-B p105 subunit","accession":"P19838","gene":"NFKB1","description":"NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-2.743491516057702,"antibodyCount":1762,"monoclonalCount":226,"pubmedCount":null,"jensenScore":505.022021,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":64.54162177486675,"pubTatorScore":3.8605698414012086,"self":"https://pharos.nih.gov/idg/api/v1/targets(18917)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":3301,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/properties"},"_links":{"count":3512,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/links"},"_synonyms":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/synonyms"},"_publications":{"count":2592,"href":"https://pharos.nih.gov/idg/api/v1/targets(18917)/publications"},"_namespace":null},{"id":18918,"version":2,"created":1555018658000,"modified":1555018661000,"deprecated":false,"name":"ATPase family AAA domain-containing protein 3B","accession":"Q5T9A4","gene":"ATAD3B","description":"May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8346326164696298,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.271367,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.50232735942464,"pubTatorScore":0.8522765229330588,"self":"https://pharos.nih.gov/idg/api/v1/targets(18918)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(18918)/publications"},"_namespace":null},{"id":18919,"version":2,"created":1555018662000,"modified":1555018668000,"deprecated":false,"name":"DNA polymerase zeta catalytic subunit","accession":"O60673","gene":"REV3L","description":"Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2010822316906276,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":158.499291,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.352661968772,"pubTatorScore":1.8073526808166966,"self":"https://pharos.nih.gov/idg/api/v1/targets(18919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(18919)/publications"},"_namespace":null},{"id":18920,"version":3,"created":1555018669000,"modified":1555044952000,"deprecated":false,"name":"Pituitary adenylate cyclase-activating polypeptide","accession":"P18509","gene":"ADCYAP1","description":"Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0511519795796183,"antibodyCount":174,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1255.156686,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":34.03889175707268,"pubTatorScore":2.7409151466686907,"self":"https://pharos.nih.gov/idg/api/v1/targets(18920)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(18920)/publications"},"_namespace":null},{"id":18921,"version":3,"created":1555018676000,"modified":1555044953000,"deprecated":false,"name":"Cell cycle checkpoint protein RAD1","accession":"O60671","gene":"RAD1","description":"Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.9171259852291596,"antibodyCount":245,"monoclonalCount":71,"pubmedCount":null,"jensenScore":78.345802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.24103558649805,"pubTatorScore":2.02409183284047,"self":"https://pharos.nih.gov/idg/api/v1/targets(18921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(18921)/publications"},"_namespace":null},{"id":18922,"version":3,"created":1555018683000,"modified":1555044955000,"deprecated":false,"name":"Ephexin-1","accession":"Q8N5V2","gene":"NGEF","description":"Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1828778104174322,"antibodyCount":77,"monoclonalCount":5,"pubmedCount":null,"jensenScore":15.660931,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":33.03328046269165,"pubTatorScore":0.8684857949700635,"self":"https://pharos.nih.gov/idg/api/v1/targets(18922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(18922)/publications"},"_namespace":null},{"id":18923,"version":2,"created":1555018689000,"modified":1555018689000,"deprecated":false,"name":"Putative speedy protein-like protein 3","accession":"A6NJR5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(18923)/publications"},"_namespace":null},{"id":18924,"version":2,"created":1555018689000,"modified":1555018694000,"deprecated":false,"name":"Inactive ubiquitin carboxyl-terminal hydrolase 53","accession":"Q70EK8","gene":"USP53","description":"Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.02374410310654272,"antibodyCount":61,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.535714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.17500091800729,"pubTatorScore":-0.1760916933503803,"self":"https://pharos.nih.gov/idg/api/v1/targets(18924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(18924)/publications"},"_namespace":null},{"id":18925,"version":2,"created":1555018695000,"modified":1555018698000,"deprecated":false,"name":"L-lactate dehydrogenase C chain","accession":"P07864","gene":"LDHC","description":"Possible role in sperm motility.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.715260293781856,"antibodyCount":181,"monoclonalCount":15,"pubmedCount":null,"jensenScore":512.101056,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.832366113551434,"pubTatorScore":2.3715515576481057,"self":"https://pharos.nih.gov/idg/api/v1/targets(18925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(18925)/publications"},"_namespace":null},{"id":18926,"version":2,"created":1555018699000,"modified":1555018703000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 51","accession":"Q70EK9","gene":"USP51","description":"Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.06159606876482926,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.346464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.224634831941618,"pubTatorScore":-0.25218128028125936,"self":"https://pharos.nih.gov/idg/api/v1/targets(18926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(18926)/publications"},"_namespace":null},{"id":18927,"version":2,"created":1555018703000,"modified":1555018709000,"deprecated":false,"name":"Seizure 6-like protein 2","accession":"Q6UXD5","gene":"SEZ6L2","description":"May contribute to specialized endoplasmic reticulum functions in neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2567953676783747,"antibodyCount":56,"monoclonalCount":6,"pubmedCount":null,"jensenScore":14.003352,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.35477654137791,"pubTatorScore":0.8585239640181548,"self":"https://pharos.nih.gov/idg/api/v1/targets(18927)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(18927)/publications"},"_namespace":null},{"id":18928,"version":2,"created":1555018710000,"modified":1555018717000,"deprecated":false,"name":"T-cell differentiation antigen CD6","accession":"P30203","gene":"CD6","description":"Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.073518642523458,"antibodyCount":707,"monoclonalCount":567,"pubmedCount":null,"jensenScore":1124.266478,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.752802635134266,"pubTatorScore":2.7169342618173493,"self":"https://pharos.nih.gov/idg/api/v1/targets(18928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(18928)/publications"},"_namespace":null},{"id":18929,"version":2,"created":1555018718000,"modified":1555018720000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 7","accession":"Q6UXD7","gene":"SLC49A3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5362427068383191,"antibodyCount":18,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.121795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4648869792587226,"self":"https://pharos.nih.gov/idg/api/v1/targets(18929)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(18929)/publications"},"_namespace":null},{"id":18930,"version":2,"created":1555018721000,"modified":1555018723000,"deprecated":false,"name":"Zinc finger protein 543","accession":"Q08ER8","gene":"ZNF543","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.12493873552256378,"antibodyCount":87,"monoclonalCount":7,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.745327817923087,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(18930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(18930)/publications"},"_namespace":null},{"id":18931,"version":2,"created":1555018724000,"modified":1555018730000,"deprecated":false,"name":"Transforming acidic coiled-coil-containing protein 2","accession":"O95359","gene":"TACC2","description":"Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. 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