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Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.3142430389713395,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":19.223421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.7338635805298,"pubTatorScore":1.6386242865691485,"self":"https://pharos.nih.gov/idg/api/v1/targets(15137)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(15137)/publications"},"_namespace":null},{"id":15138,"version":2,"created":1554980518000,"modified":1554980524000,"deprecated":false,"name":"Splicing factor 3B subunit 4","accession":"Q15427","gene":"SF3B4","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4441632884845679,"antibodyCount":222,"monoclonalCount":38,"pubmedCount":null,"jensenScore":28.695034,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.98212851689296,"pubTatorScore":1.3633950981167053,"self":"https://pharos.nih.gov/idg/api/v1/targets(15138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(15138)/publications"},"_namespace":null},{"id":15139,"version":3,"created":1554980525000,"modified":1555042479000,"deprecated":false,"name":"Serine/threonine-protein kinase haspin","accession":"Q8TF76","gene":"HASPIN","description":"Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.703908544997451,"antibodyCount":120,"monoclonalCount":5,"pubmedCount":null,"jensenScore":49.987513,"patentCount":2918,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":0.0,"pubTatorScore":1.528631064169227,"self":"https://pharos.nih.gov/idg/api/v1/targets(15139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(15139)/publications"},"_namespace":null},{"id":15140,"version":2,"created":1554980530000,"modified":1554980534000,"deprecated":false,"name":"EH domain-binding protein 1-like protein 1","accession":"Q8N3D4","gene":"EHBP1L1","description":"May act as Rab effector protein and play a role in vesicle trafficking.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.237574345794961,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.733168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.27356203924023,"pubTatorScore":0.02802885931724794,"self":"https://pharos.nih.gov/idg/api/v1/targets(15140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(15140)/publications"},"_namespace":null},{"id":15141,"version":2,"created":1554980534000,"modified":1554980539000,"deprecated":false,"name":"Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial","accession":"Q96HY7","gene":"DHTKD1","description":"The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9660634766671389,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.644047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.23433936823812,"pubTatorScore":0.9259992492903653,"self":"https://pharos.nih.gov/idg/api/v1/targets(15141)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(15141)/publications"},"_namespace":null},{"id":15142,"version":2,"created":1554980540000,"modified":1554980541000,"deprecated":false,"name":"Smith-Magenis syndrome chromosomal region candidate gene 5 protein","accession":"Q8TEV8","gene":"SMCR5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.057430212581303,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(15142)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(15142)/publications"},"_namespace":null},{"id":15143,"version":2,"created":1554980541000,"modified":1554980544000,"deprecated":false,"name":"Guanine nucleotide exchange protein SMCR8","accession":"Q8TEV9","gene":"SMCR8","description":"Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5788301567619928,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.028096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.427461381650836,"pubTatorScore":0.19299206263748017,"self":"https://pharos.nih.gov/idg/api/v1/targets(15143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(15143)/publications"},"_namespace":null},{"id":15144,"version":3,"created":1554980545000,"modified":1555042480000,"deprecated":false,"name":"SUMO-activating enzyme subunit 2","accession":"Q9UBT2","gene":"UBA2","description":"The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. 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Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.421421526752512,"antibodyCount":224,"monoclonalCount":37,"pubmedCount":null,"jensenScore":256.317154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.10252999555352,"pubTatorScore":2.1526195388794203,"self":"https://pharos.nih.gov/idg/api/v1/targets(15147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/links"},"_synonyms":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(15147)/publications"},"_namespace":null},{"id":15148,"version":2,"created":1554980565000,"modified":1554980569000,"deprecated":false,"name":"Zinc finger protein 415","accession":"Q09FC8","gene":"ZNF415","description":"Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.003113233438796746,"antibodyCount":116,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.161039,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.989107715702552,"pubTatorScore":-0.07058107428570728,"self":"https://pharos.nih.gov/idg/api/v1/targets(15148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(15148)/publications"},"_namespace":null},{"id":15149,"version":3,"created":1554980570000,"modified":1555042482000,"deprecated":false,"name":"Dickkopf-related protein 4","accession":"Q9UBT3","gene":"DKK4","description":"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4323245605146708,"antibodyCount":316,"monoclonalCount":26,"pubmedCount":null,"jensenScore":27.423218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":22.424399848599453,"pubTatorScore":1.4291683346579616,"self":"https://pharos.nih.gov/idg/api/v1/targets(15149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/properties"},"_links":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(15149)/publications"},"_namespace":null},{"id":15150,"version":3,"created":1554980573000,"modified":1555042483000,"deprecated":false,"name":"Enoyl-CoA hydratase, mitochondrial","accession":"P30084","gene":"ECHS1","description":"Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6963687858462566,"antibodyCount":162,"monoclonalCount":17,"pubmedCount":null,"jensenScore":49.537852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.04774050600639,"pubTatorScore":1.4453446853869458,"self":"https://pharos.nih.gov/idg/api/v1/targets(15150)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":494,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(15150)/publications"},"_namespace":null},{"id":15151,"version":2,"created":1554980579000,"modified":1554980584000,"deprecated":false,"name":"Thiosulfate sulfurtransferase","accession":"Q16762","gene":"TST","description":"Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. 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Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.433065445630572,"antibodyCount":173,"monoclonalCount":5,"pubmedCount":null,"jensenScore":261.217234,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.042241347234025,"pubTatorScore":2.2071740513922724,"self":"https://pharos.nih.gov/idg/api/v1/targets(15271)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(15271)/publications"},"_namespace":null},{"id":15272,"version":2,"created":1554981414000,"modified":1554981418000,"deprecated":false,"name":"SERTA domain-containing protein 2","accession":"Q14140","gene":"SERTAD2","description":"Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. 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Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8012239931119279,"antibodyCount":119,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.349285,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.27043389330013,"pubTatorScore":0.8175508928357705,"self":"https://pharos.nih.gov/idg/api/v1/targets(15272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(15272)/publications"},"_namespace":null},{"id":15273,"version":3,"created":1554981419000,"modified":1555042583000,"deprecated":false,"name":"Dickkopf-related protein 3","accession":"Q9UBP4","gene":"DKK3","description":"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. 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Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. 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Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. 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Regulates the expression of CCNA1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.640407335282206,"antibodyCount":111,"monoclonalCount":23,"pubmedCount":null,"jensenScore":433.691538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":41.529668921731584,"pubTatorScore":2.363243464783708,"self":"https://pharos.nih.gov/idg/api/v1/targets(15279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(15279)/publications"},"_namespace":null},{"id":15280,"version":2,"created":1554981467000,"modified":1554981472000,"deprecated":false,"name":"Cyclic AMP-responsive element-binding protein 3-like protein 4","accession":"Q8TEY5","gene":"CREB3L4","description":"Transcriptional activator that may play a role in the unfolded protein response. 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Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6487532841263153,"antibodyCount":188,"monoclonalCount":33,"pubmedCount":null,"jensenScore":47.58176,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.77448115926723,"pubTatorScore":1.1560696485140647,"self":"https://pharos.nih.gov/idg/api/v1/targets(15280)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(15280)/publications"},"_namespace":null},{"id":15281,"version":2,"created":1554981472000,"modified":1554981476000,"deprecated":false,"name":"MORC family CW-type zinc finger protein 3","accession":"Q14149","gene":"MORC3","description":"Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). 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May be required for influenza A transcription during viral infection (PubMed:26202233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6124083804093996,"antibodyCount":61,"monoclonalCount":8,"pubmedCount":null,"jensenScore":36.603589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.36505231059523,"pubTatorScore":1.344937805667503,"self":"https://pharos.nih.gov/idg/api/v1/targets(15281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(15281)/publications"},"_namespace":null},{"id":15282,"version":3,"created":1554981477000,"modified":1555042588000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 33","accession":"Q8TEY7","gene":"USP33","description":"Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. 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Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. 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The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. 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Acts as an attachment receptor for west-nile virus (PubMed:16415006). Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.800617862013195,"antibodyCount":983,"monoclonalCount":644,"pubmedCount":null,"jensenScore":714.528479,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":30.699356789885904,"pubTatorScore":2.5482612522513004,"self":"https://pharos.nih.gov/idg/api/v1/targets(15368)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":612,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/properties"},"_links":{"count":1214,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/links"},"_synonyms":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/synonyms"},"_publications":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(15368)/publications"},"_namespace":null},{"id":15369,"version":3,"created":1554981918000,"modified":1555042645000,"deprecated":false,"name":"Far upstream element-binding protein 3","accession":"Q96I24","gene":"FUBP3","description":"May interact with single-stranded DNA from the far-upstream element (FUSE). 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Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. 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The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.915212881282686,"antibodyCount":692,"monoclonalCount":160,"pubmedCount":null,"jensenScore":803.446597,"patentCount":44319,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":52.907734265074666,"pubTatorScore":2.709055229859793,"self":"https://pharos.nih.gov/idg/api/v1/targets(15670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":711,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/properties"},"_links":{"count":1943,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/synonyms"},"_publications":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(15670)/publications"},"_namespace":null},{"id":15671,"version":3,"created":1554984382000,"modified":1555042845000,"deprecated":false,"name":"Polycomb protein SCMH1","accession":"Q96GD3","gene":"SCMH1","description":"Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.5657087819232881,"antibodyCount":140,"monoclonalCount":50,"pubmedCount":null,"jensenScore":4.103939,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.41030228875138,"pubTatorScore":0.45014113729906857,"self":"https://pharos.nih.gov/idg/api/v1/targets(15671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(15671)/publications"},"_namespace":null},{"id":15672,"version":2,"created":1554984386000,"modified":1554984389000,"deprecated":false,"name":"C-type lectin domain family 4 member F","accession":"Q8N1N0","gene":"CLEC4F","description":"Receptor with an affinity for galactose and fucose. 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The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). 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In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.1934338114239278,"antibodyCount":84,"monoclonalCount":6,"pubmedCount":null,"jensenScore":17.894784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.478229122730994,"pubTatorScore":1.7092121247073575,"self":"https://pharos.nih.gov/idg/api/v1/targets(15676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(15676)/publications"},"_namespace":null},{"id":15677,"version":3,"created":1554984411000,"modified":1555042850000,"deprecated":false,"name":"C-C motif chemokine 21","accession":"O00585","gene":"CCL21","description":"Inhibits hemopoiesis and stimulates chemotaxis. 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Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.880282340894505,"antibodyCount":381,"monoclonalCount":64,"pubmedCount":null,"jensenScore":733.503092,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":27.69825602946873,"pubTatorScore":2.4843699160069175,"self":"https://pharos.nih.gov/idg/api/v1/targets(15677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(15677)/publications"},"_namespace":null},{"id":15678,"version":3,"created":1554984415000,"modified":1555042851000,"deprecated":false,"name":"Ribonuclease T2","accession":"O00584","gene":"RNASET2","description":"Has ribonuclease activity, with higher activity at acidic pH. 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Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7884545602067234,"antibodyCount":35,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.635221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.785979118485653,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(15722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(15722)/publications"},"_namespace":null},{"id":15723,"version":2,"created":1554984917000,"modified":1554984921000,"deprecated":false,"name":"Whirlin","accession":"Q9P202","gene":"WHRN","description":"Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7495848774318001,"antibodyCount":123,"monoclonalCount":39,"pubmedCount":null,"jensenScore":54.088528,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.2162620964399613,"self":"https://pharos.nih.gov/idg/api/v1/targets(15723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(15723)/publications"},"_namespace":null},{"id":15724,"version":2,"created":1554984922000,"modified":1554984926000,"deprecated":false,"name":"BTB/POZ domain-containing protein 7","accession":"Q9P203","gene":"BTBD7","description":"Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1940516210018026,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.332593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.69632847195383,"pubTatorScore":0.9225524321562364,"self":"https://pharos.nih.gov/idg/api/v1/targets(15724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(15724)/publications"},"_namespace":null},{"id":15725,"version":3,"created":1554984926000,"modified":1555042875000,"deprecated":false,"name":"Mitotic-spindle organizing protein 1","accession":"Q08AG7","gene":"MZT1","description":"Required for gamma-tubulin complex recruitment to the centrosome.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8780154246376088,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.283595,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":28.057356350466545,"pubTatorScore":0.6989700043360189,"self":"https://pharos.nih.gov/idg/api/v1/targets(15725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(15725)/publications"},"_namespace":null},{"id":15726,"version":2,"created":1554984932000,"modified":1554984935000,"deprecated":false,"name":"Cytochrome b5 reductase 4","accession":"Q7L1T6","gene":"CYB5R4","description":"NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1555407183011783,"antibodyCount":107,"monoclonalCount":39,"pubmedCount":null,"jensenScore":17.526664,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.65807367642358,"pubTatorScore":0.7118072290411911,"self":"https://pharos.nih.gov/idg/api/v1/targets(15726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(15726)/publications"},"_namespace":null},{"id":15727,"version":2,"created":1554984936000,"modified":1554984940000,"deprecated":false,"name":"Uncharacterized protein KIAA1522","accession":"Q9P206","gene":"KIAA1522","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.21998348511502275,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.122409,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.660288145676052,"pubTatorScore":0.15103534228890542,"self":"https://pharos.nih.gov/idg/api/v1/targets(15727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(15727)/publications"},"_namespace":null},{"id":15728,"version":2,"created":1554984940000,"modified":1554984941000,"deprecated":false,"name":"Ribonuclease 8","accession":"Q8TDE3","gene":"RNASE8","description":"Has a low ribonuclease activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9030899869919435,"antibodyCount":60,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.013889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.693997386813589,"pubTatorScore":0.8016323233755616,"self":"https://pharos.nih.gov/idg/api/v1/targets(15728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/properties"},"_links":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(15728)/publications"},"_namespace":null},{"id":15729,"version":3,"created":1554984941000,"modified":1555042876000,"deprecated":false,"name":"Centrosomal protein of 72 kDa","accession":"Q9P209","gene":"CEP72","description":"Involved in the recruitment of key centrosomal proteins to the centrosome. 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Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7310512811400259,"antibodyCount":110,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.22109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":33.70859584300126,"pubTatorScore":0.6715050573872213,"self":"https://pharos.nih.gov/idg/api/v1/targets(15729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(15729)/publications"},"_namespace":null},{"id":15730,"version":2,"created":1554984946000,"modified":1554984947000,"deprecated":false,"name":"Uncharacterized protein C11orf71","accession":"Q6IPW1","gene":"C11orf71","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(15730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/properties"},"_links":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(15730)/publications"},"_namespace":null},{"id":15731,"version":3,"created":1554984947000,"modified":1555042878000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(k) subunit alpha","accession":"P08754","gene":"GNAI3","description":"Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4221940821988932,"antibodyCount":136,"monoclonalCount":5,"pubmedCount":null,"jensenScore":24.792931,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":48.17227342732339,"pubTatorScore":1.6195694676050696,"self":"https://pharos.nih.gov/idg/api/v1/targets(15731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/synonyms"},"_publications":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(15731)/publications"},"_namespace":null},{"id":15732,"version":2,"created":1554984954000,"modified":1554984956000,"deprecated":false,"name":"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3","accession":"P0C6S8","gene":"LINGO3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.1497623216000243,"antibodyCount":63,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.382857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.455464895919253,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(15732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/properties"},"_links":{"count":692,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(15732)/publications"},"_namespace":null},{"id":15733,"version":3,"created":1554984957000,"modified":1555042879000,"deprecated":false,"name":"Dedicator of cytokinesis protein 4","accession":"Q8N1I0","gene":"DOCK4","description":"Involved in regulation of adherens junction between cells. 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Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.657374037980198,"antibodyCount":101,"monoclonalCount":48,"pubmedCount":null,"jensenScore":45.823699,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.39158932378023,"pubTatorScore":1.5608638407476751,"self":"https://pharos.nih.gov/idg/api/v1/targets(15733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(15733)/publications"},"_namespace":null},{"id":15734,"version":3,"created":1554984963000,"modified":1555042881000,"deprecated":false,"name":"Delta-like protein 1","accession":"O00548","gene":"DLL1","description":"Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. 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Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8563260100778446,"antibodyCount":67,"monoclonalCount":22,"pubmedCount":null,"jensenScore":9.127792,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.548852375721484,"pubTatorScore":0.6154239528859439,"self":"https://pharos.nih.gov/idg/api/v1/targets(15799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(15799)/publications"},"_namespace":null},{"id":15800,"version":2,"created":1554985279000,"modified":1554985283000,"deprecated":false,"name":"Claudin-5","accession":"O00501","gene":"CLDN5","description":"Plays a major role in tight junction-specific obliteration of the intercellular space.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.589675005580801,"antibodyCount":300,"monoclonalCount":55,"pubmedCount":null,"jensenScore":349.394923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.95248940168712,"pubTatorScore":2.2587255571536,"self":"https://pharos.nih.gov/idg/api/v1/targets(15800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(15800)/publications"},"_namespace":null},{"id":15801,"version":3,"created":1554985284000,"modified":1555042916000,"deprecated":false,"name":"Neurotrophin receptor-interacting factor homolog","accession":"Q96GC6","gene":"ZNF274","description":"Probable transcription repressor. 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The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.440915843214341,"antibodyCount":194,"monoclonalCount":61,"pubmedCount":null,"jensenScore":23.10455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":38.47979249456351,"pubTatorScore":1.183111589269761,"self":"https://pharos.nih.gov/idg/api/v1/targets(15801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(15801)/publications"},"_namespace":null},{"id":15802,"version":3,"created":1554985289000,"modified":1555042919000,"deprecated":false,"name":"Fibroblast growth factor 8","accession":"P55075","gene":"FGF8","description":"Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7336812649261732,"antibodyCount":299,"monoclonalCount":95,"pubmedCount":null,"jensenScore":532.003896,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":95,"knowledgeAvailability":35.32691260182575,"pubTatorScore":2.3457720576270393,"self":"https://pharos.nih.gov/idg/api/v1/targets(15802)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(15802)/publications"},"_namespace":null},{"id":15803,"version":2,"created":1554985294000,"modified":1554985299000,"deprecated":false,"name":"Vacuole membrane protein 1","accession":"Q96GC9","gene":"VMP1","description":"Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. 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RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2198505322535715,"antibodyCount":199,"monoclonalCount":2,"pubmedCount":null,"jensenScore":98.029864,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.42857758314699,"pubTatorScore":2.257393089597244,"self":"https://pharos.nih.gov/idg/api/v1/targets(15804)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(15804)/publications"},"_namespace":null},{"id":15805,"version":4,"created":1554985304000,"modified":1555042920000,"deprecated":false,"name":"Transitional endoplasmic reticulum ATPase","accession":"P55072","gene":"VCP","description":"Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. 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Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). 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Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). 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Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1039132594941905,"antibodyCount":219,"monoclonalCount":71,"pubmedCount":null,"jensenScore":151.972489,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":43.60494078906448,"pubTatorScore":1.495314850111537,"self":"https://pharos.nih.gov/idg/api/v1/targets(15903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/properties"},"_links":{"count":1121,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(15903)/publications"},"_namespace":null},{"id":15904,"version":3,"created":1554986545000,"modified":1555042989000,"deprecated":false,"name":"RalA-binding protein 1","accession":"Q15311","gene":"RALBP1","description":"Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.996667448512697,"antibodyCount":320,"monoclonalCount":105,"pubmedCount":null,"jensenScore":110.826682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":47.893626378649955,"pubTatorScore":1.966622659948005,"self":"https://pharos.nih.gov/idg/api/v1/targets(15904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(15904)/publications"},"_namespace":null},{"id":15905,"version":3,"created":1554986551000,"modified":1555042991000,"deprecated":false,"name":"Growth/differentiation factor 5","accession":"P43026","gene":"GDF5","description":"Growth factor involved in bone and cartilage formation. 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Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.919874828082859,"antibodyCount":226,"monoclonalCount":43,"pubmedCount":null,"jensenScore":81.576667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":24.89233969756694,"pubTatorScore":1.8690385918168646,"self":"https://pharos.nih.gov/idg/api/v1/targets(15907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(15907)/publications"},"_namespace":null},{"id":15908,"version":3,"created":1554986569000,"modified":1555042994000,"deprecated":false,"name":"Nuclear factor interleukin-3-regulated protein","accession":"Q16649","gene":"NFIL3","description":"Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9160282229678731,"antibodyCount":265,"monoclonalCount":46,"pubmedCount":null,"jensenScore":90.668346,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.529929096818876,"pubTatorScore":1.591086900237716,"self":"https://pharos.nih.gov/idg/api/v1/targets(15908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(15908)/publications"},"_namespace":null},{"id":15909,"version":2,"created":1554986574000,"modified":1554986578000,"deprecated":false,"name":"6.8 kDa mitochondrial proteolipid","accession":"P56378","gene":"ATP5MPL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8383992782859753,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.73869,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(15909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(15909)/publications"},"_namespace":null},{"id":15910,"version":3,"created":1554986579000,"modified":1555042996000,"deprecated":false,"name":"MAP kinase-activated protein kinase 3","accession":"Q16644","gene":"MAPKAPK3","description":"Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. 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Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. 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Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.4792414356877672,"antibodyCount":1450,"monoclonalCount":615,"pubmedCount":null,"jensenScore":3234.037708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":60.3028480435792,"pubTatorScore":3.708909405117298,"self":"https://pharos.nih.gov/idg/api/v1/targets(15978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":3106,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/properties"},"_links":{"count":3648,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/links"},"_synonyms":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/synonyms"},"_publications":{"count":2565,"href":"https://pharos.nih.gov/idg/api/v1/targets(15978)/publications"},"_namespace":null},{"id":15979,"version":2,"created":1554987190000,"modified":1554987195000,"deprecated":false,"name":"Protocadherin-10","accession":"Q9P2E7","gene":"PCDH10","description":"Potential calcium-dependent cell-adhesion protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7559045537445526,"antibodyCount":104,"monoclonalCount":28,"pubmedCount":null,"jensenScore":63.804889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.34771763034161,"pubTatorScore":1.6930397543031135,"self":"https://pharos.nih.gov/idg/api/v1/targets(15979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(15979)/publications"},"_namespace":null},{"id":15980,"version":2,"created":1554987196000,"modified":1554987208000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily C member 3","accession":"Q14003","gene":"KCNC3","description":"Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.7754097085585814,"antibodyCount":232,"monoclonalCount":45,"pubmedCount":null,"jensenScore":61.876747,"patentCount":2281,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.25472864733887,"pubTatorScore":1.6123440857507347,"self":"https://pharos.nih.gov/idg/api/v1/targets(15980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(15980)/publications"},"_namespace":null},{"id":15981,"version":2,"created":1554987209000,"modified":1554987214000,"deprecated":false,"name":"Bax inhibitor 1","accession":"P55061","gene":"TMBIM6","description":"Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.475153587691762,"antibodyCount":151,"monoclonalCount":122,"pubmedCount":null,"jensenScore":305.327869,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.54949456068722,"pubTatorScore":2.0550569071809344,"self":"https://pharos.nih.gov/idg/api/v1/targets(15981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(15981)/publications"},"_namespace":null},{"id":15982,"version":2,"created":1554987215000,"modified":1554987228000,"deprecated":false,"name":"Excitatory amino acid transporter 1","accession":"P43003","gene":"SLC1A3","description":"Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.7640172965181606,"antibodyCount":221,"monoclonalCount":28,"pubmedCount":null,"jensenScore":569.663356,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.51655606279393,"pubTatorScore":2.3940508382256214,"self":"https://pharos.nih.gov/idg/api/v1/targets(15982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/properties"},"_links":{"count":1046,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(15982)/publications"},"_namespace":null},{"id":15983,"version":2,"created":1554987229000,"modified":1554987233000,"deprecated":false,"name":"Lethal(2) giant larvae protein homolog 1","accession":"Q15334","gene":"LLGL1","description":"Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0920085342087247,"antibodyCount":143,"monoclonalCount":9,"pubmedCount":null,"jensenScore":1212.432042,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.747715167543205,"pubTatorScore":1.3963653937446907,"self":"https://pharos.nih.gov/idg/api/v1/targets(15983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(15983)/publications"},"_namespace":null},{"id":15984,"version":3,"created":1554987234000,"modified":1555043046000,"deprecated":false,"name":"ER membrane protein complex subunit 4","accession":"Q5J8M3","gene":"EMC4","description":"May mediate anti-apoptotic activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5854607290742062,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.947223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":26.31441763156565,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(15984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(15984)/publications"},"_namespace":null},{"id":15985,"version":2,"created":1554987239000,"modified":1554987242000,"deprecated":false,"name":"Carcinoembryonic antigen-related cell adhesion molecule 7","accession":"Q14002","gene":"CEACAM7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1199531567791627,"antibodyCount":151,"monoclonalCount":31,"pubmedCount":null,"jensenScore":15.243118,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.86172355285111,"pubTatorScore":1.2687985730098956,"self":"https://pharos.nih.gov/idg/api/v1/targets(15985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/properties"},"_links":{"count":550,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(15985)/publications"},"_namespace":null},{"id":15986,"version":2,"created":1554987243000,"modified":1554987247000,"deprecated":false,"name":"E3 ubiquitin-protein ligase MARCH4","accession":"Q9P2E8","gene":"MARCH4","description":"E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2436141965941652,"antibodyCount":149,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.935714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.35578233468354,"pubTatorScore":2.177151570452557,"self":"https://pharos.nih.gov/idg/api/v1/targets(15986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(15986)/publications"},"_namespace":null},{"id":15987,"version":2,"created":1554987248000,"modified":1554987252000,"deprecated":false,"name":"Exportin-2","accession":"P55060","gene":"CSE1L","description":"Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9877095714567803,"antibodyCount":408,"monoclonalCount":213,"pubmedCount":null,"jensenScore":99.194053,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.31134352228251,"pubTatorScore":2.1140365819838856,"self":"https://pharos.nih.gov/idg/api/v1/targets(15987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(15987)/publications"},"_namespace":null},{"id":15988,"version":2,"created":1554987253000,"modified":1554987264000,"deprecated":false,"name":"Excitatory amino acid transporter 2","accession":"P43004","gene":"SLC1A2","description":"Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.962366365105924,"antibodyCount":187,"monoclonalCount":87,"pubmedCount":null,"jensenScore":939.639454,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.49533193887202,"pubTatorScore":2.609021220193143,"self":"https://pharos.nih.gov/idg/api/v1/targets(15988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(15988)/publications"},"_namespace":null},{"id":15989,"version":3,"created":1554987266000,"modified":1555043048000,"deprecated":false,"name":"Excitatory amino acid transporter 3","accession":"P43005","gene":"SLC1A1","description":"Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.5965980510753712,"antibodyCount":251,"monoclonalCount":104,"pubmedCount":null,"jensenScore":395.602392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":45.73666298096971,"pubTatorScore":2.3704303178030326,"self":"https://pharos.nih.gov/idg/api/v1/targets(15989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/synonyms"},"_publications":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(15989)/publications"},"_namespace":null},{"id":15990,"version":2,"created":1554987276000,"modified":1554987285000,"deprecated":false,"name":"Ribosome-binding protein 1","accession":"Q9P2E9","gene":"RRBP1","description":"Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.645302012486473,"antibodyCount":157,"monoclonalCount":22,"pubmedCount":null,"jensenScore":433.273213,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.91107608036585,"pubTatorScore":1.4372407760787191,"self":"https://pharos.nih.gov/idg/api/v1/targets(15990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/properties"},"_links":{"count":1188,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(15990)/publications"},"_namespace":null},{"id":15991,"version":2,"created":1554987286000,"modified":1554987287000,"deprecated":false,"name":"Guanylate cyclase activator 2B","accession":"Q16661","gene":"GUCA2B","description":"Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3074459097599882,"antibodyCount":137,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.332906,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.595413407000215,"pubTatorScore":1.9570004359097781,"self":"https://pharos.nih.gov/idg/api/v1/targets(15991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(15991)/properties"},"_links":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(15991)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(15991)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(15991)/publications"},"_namespace":null},{"id":15992,"version":3,"created":1554987287000,"modified":1554987361000,"deprecated":false,"name":"Glutamate carboxypeptidase 2","accession":"Q04609","gene":"FOLH1","description":"Also exhibits a dipeptidyl-peptidase IV type activity. 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Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.307078120741118,"antibodyCount":142,"monoclonalCount":26,"pubmedCount":null,"jensenScore":20.472128,"patentCount":2689,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":47.854671267058364,"pubTatorScore":1.1091261659397051,"self":"https://pharos.nih.gov/idg/api/v1/targets(15997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(15997)/properties"},"_links":{"count":1104,"href":"https://pharos.nih.gov/idg/api/v1/targets(15997)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(15997)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(15997)/publications"},"_namespace":null},{"id":15998,"version":2,"created":1554987390000,"modified":1554987392000,"deprecated":false,"name":"Protein PPP5D1","accession":"E7EU14","gene":"PPP5D1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.286374609518578,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(15998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(15998)/properties"},"_links":{"count":751,"href":"https://pharos.nih.gov/idg/api/v1/targets(15998)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(15998)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(15998)/publications"},"_namespace":null},{"id":15999,"version":3,"created":1554987393000,"modified":1555043056000,"deprecated":false,"name":"RB1-inducible coiled-coil protein 1","accession":"Q8TDY2","gene":"RB1CC1","description":"Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). 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Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9697160961886555,"antibodyCount":246,"monoclonalCount":58,"pubmedCount":null,"jensenScore":112.661296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.26615534518519,"pubTatorScore":2.067882644355112,"self":"https://pharos.nih.gov/idg/api/v1/targets(16000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(16000)/properties"},"_links":{"count":1237,"href":"https://pharos.nih.gov/idg/api/v1/targets(16000)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(16000)/synonyms"},"_publications":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(16000)/publications"},"_namespace":null}]}