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The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.809732750308803,"antibodyCount":288,"monoclonalCount":139,"pubmedCount":null,"jensenScore":614.410579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.724046692952115,"pubTatorScore":1.6093084703832954,"self":"https://pharos.nih.gov/idg/api/v1/targets(14001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":665,"href":"https://pharos.nih.gov/idg/api/v1/targets(14001)/properties"},"_links":{"count":1215,"href":"https://pharos.nih.gov/idg/api/v1/targets(14001)/links"},"_synonyms":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(14001)/synonyms"},"_publications":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(14001)/publications"},"_namespace":null},{"id":14002,"version":2,"created":1554969684000,"modified":1554969688000,"deprecated":false,"name":"Spindle and kinetochore-associated protein 1","accession":"Q96BD8","gene":"SKA1","description":"Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5022799364700998,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":32.02381,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.849755204085724,"pubTatorScore":1.2721317901423181,"self":"https://pharos.nih.gov/idg/api/v1/targets(14002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(14002)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(14002)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(14002)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(14002)/publications"},"_namespace":null},{"id":14003,"version":4,"created":1554969689000,"modified":1555041763000,"deprecated":false,"name":"Vasopressin V1b receptor","accession":"P47901","gene":"AVPR1B","description":"Receptor for arginine vasopressin. 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Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). 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Terminal step in leucine catabolism. 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This protein is also a carboxypeptidase and can deamidate tachykinins.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.0710053572575693,"antibodyCount":300,"monoclonalCount":49,"pubmedCount":null,"jensenScore":1162.733681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.335880826077705,"pubTatorScore":2.474815124913329,"self":"https://pharos.nih.gov/idg/api/v1/targets(14008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(14008)/properties"},"_links":{"count":1484,"href":"https://pharos.nih.gov/idg/api/v1/targets(14008)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(14008)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(14008)/publications"},"_namespace":null},{"id":14009,"version":2,"created":1554969820000,"modified":1554969823000,"deprecated":false,"name":"Tumor necrosis factor ligand superfamily member 13","accession":"O75888","gene":"TNFSF13","description":"Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4098030663982648,"antibodyCount":527,"monoclonalCount":106,"pubmedCount":null,"jensenScore":22.849379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.90300240122511,"pubTatorScore":2.567796967900633,"self":"https://pharos.nih.gov/idg/api/v1/targets(14009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(14009)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(14009)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(14009)/synonyms"},"_publications":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(14009)/publications"},"_namespace":null},{"id":14010,"version":3,"created":1554969824000,"modified":1555041767000,"deprecated":false,"name":"CST complex subunit STN1","accession":"Q9H668","gene":"STN1","description":"Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5383824862273607,"antibodyCount":116,"monoclonalCount":36,"pubmedCount":null,"jensenScore":29.051309,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":0.0,"pubTatorScore":1.2782998462647928,"self":"https://pharos.nih.gov/idg/api/v1/targets(14010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(14010)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(14010)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(14010)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(14010)/publications"},"_namespace":null},{"id":14011,"version":3,"created":1554969830000,"modified":1555041769000,"deprecated":false,"name":"Homeobox protein Hox-B7","accession":"P09629","gene":"HOXB7","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9793483178693352,"antibodyCount":303,"monoclonalCount":101,"pubmedCount":null,"jensenScore":103.991397,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.14163033116076,"pubTatorScore":1.9020045458027472,"self":"https://pharos.nih.gov/idg/api/v1/targets(14011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(14011)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(14011)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(14011)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(14011)/publications"},"_namespace":null},{"id":14012,"version":3,"created":1554969834000,"modified":1555041770000,"deprecated":false,"name":"Signal transducing adapter molecule 2","accession":"O75886","gene":"STAM2","description":"Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2588300366337264,"antibodyCount":252,"monoclonalCount":33,"pubmedCount":null,"jensenScore":21.319091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.3698300306794,"pubTatorScore":1.1887036043669008,"self":"https://pharos.nih.gov/idg/api/v1/targets(14012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(14012)/properties"},"_links":{"count":1098,"href":"https://pharos.nih.gov/idg/api/v1/targets(14012)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(14012)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(14012)/publications"},"_namespace":null},{"id":14013,"version":3,"created":1554969840000,"modified":1554969867000,"deprecated":false,"name":"Vascular endothelial growth factor receptor 3","accession":"P35916","gene":"FLT4","description":"Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.729663611372935,"antibodyCount":744,"monoclonalCount":360,"pubmedCount":null,"jensenScore":518.754543,"patentCount":116835,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.63672870001831,"pubTatorScore":2.6174346554419414,"self":"https://pharos.nih.gov/idg/api/v1/targets(14013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":664,"href":"https://pharos.nih.gov/idg/api/v1/targets(14013)/properties"},"_links":{"count":1313,"href":"https://pharos.nih.gov/idg/api/v1/targets(14013)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(14013)/synonyms"},"_publications":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(14013)/publications"},"_namespace":null},{"id":14014,"version":2,"created":1554969869000,"modified":1554969871000,"deprecated":false,"name":"IGF-like family receptor 1","accession":"Q9H665","gene":"IGFLR1","description":"Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. 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Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. 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Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (PubMed:20068034). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.067993759331336,"antibodyCount":232,"monoclonalCount":46,"pubmedCount":null,"jensenScore":109.663318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.460767761876944,"pubTatorScore":2.6894061293056843,"self":"https://pharos.nih.gov/idg/api/v1/targets(14184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":635,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/properties"},"_links":{"count":1211,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(14184)/publications"},"_namespace":null},{"id":14185,"version":2,"created":1554972257000,"modified":1554972258000,"deprecated":false,"name":"Olfactory receptor 7C2","accession":"O60412","gene":"OR7C2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":862,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.422989491053507,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(14185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/properties"},"_links":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(14185)/publications"},"_namespace":null},{"id":14186,"version":2,"created":1554972258000,"modified":1554972263000,"deprecated":false,"name":"Cation-dependent mannose-6-phosphate receptor","accession":"P20645","gene":"M6PR","description":"Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. 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PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). 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The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). 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Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1890504798822465,"antibodyCount":80,"monoclonalCount":33,"pubmedCount":null,"jensenScore":12.466161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.33789851428139,"pubTatorScore":1.096841041567853,"self":"https://pharos.nih.gov/idg/api/v1/targets(14311)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(14311)/publications"},"_namespace":null},{"id":14312,"version":2,"created":1554973149000,"modified":1554973153000,"deprecated":false,"name":"Leukocyte immunoglobulin-like receptor subfamily B member 2","accession":"Q8N423","gene":"LILRB2","description":"Receptor for class I MHC antigens. 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Functions predominantly in APPL1-containing endosomes (PubMed:25266290).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.138678547195401,"antibodyCount":61,"monoclonalCount":10,"pubmedCount":null,"jensenScore":12.681565,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.28942098226491,"pubTatorScore":0.2825466654994366,"self":"https://pharos.nih.gov/idg/api/v1/targets(14314)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(14314)/publications"},"_namespace":null},{"id":14315,"version":3,"created":1554973163000,"modified":1555041947000,"deprecated":false,"name":"Protein Wnt-7a","accession":"O00755","gene":"WNT7A","description":"Ligand for members of the frizzled family of seven transmembrane receptors. 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Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. 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May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.323852573270847,"antibodyCount":297,"monoclonalCount":84,"pubmedCount":null,"jensenScore":217.093876,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.99858235890262,"pubTatorScore":2.0562437522235584,"self":"https://pharos.nih.gov/idg/api/v1/targets(14324)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(14324)/publications"},"_namespace":null},{"id":14325,"version":2,"created":1554973222000,"modified":1554973226000,"deprecated":false,"name":"LIM domain-containing protein ajuba","accession":"Q96IF1","gene":"AJUBA","description":"Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. 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In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. 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Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8430966524567765,"antibodyCount":241,"monoclonalCount":40,"pubmedCount":null,"jensenScore":69.149843,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.47412042746375,"pubTatorScore":2.7071899884390125,"self":"https://pharos.nih.gov/idg/api/v1/targets(14472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":641,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/properties"},"_links":{"count":1257,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/synonyms"},"_publications":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(14472)/publications"},"_namespace":null},{"id":14473,"version":3,"created":1554975350000,"modified":1555042032000,"deprecated":false,"name":"Antigen peptide transporter 2","accession":"Q03519","gene":"TAP2","description":"Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. 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Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.226641772779147,"antibodyCount":160,"monoclonalCount":8,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.09504275073112,"pubTatorScore":2.4708471886482535,"self":"https://pharos.nih.gov/idg/api/v1/targets(14473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/properties"},"_links":{"count":1104,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/synonyms"},"_publications":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(14473)/publications"},"_namespace":null},{"id":14474,"version":3,"created":1554975357000,"modified":1555042036000,"deprecated":false,"name":"Ensconsin","accession":"Q14244","gene":"MAP7","description":"Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. 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Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1561632437299254,"antibodyCount":503,"monoclonalCount":185,"pubmedCount":null,"jensenScore":1465.003886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.28394399103345,"pubTatorScore":3.187660117143953,"self":"https://pharos.nih.gov/idg/api/v1/targets(14475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/properties"},"_links":{"count":1632,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/links"},"_synonyms":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/synonyms"},"_publications":{"count":704,"href":"https://pharos.nih.gov/idg/api/v1/targets(14475)/publications"},"_namespace":null},{"id":14476,"version":2,"created":1554975375000,"modified":1554975379000,"deprecated":false,"name":"TATA box-binding protein-associated factor RNA polymerase I subunit A","accession":"Q15573","gene":"TAF1A","description":"Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8415382347077386,"antibodyCount":161,"monoclonalCount":11,"pubmedCount":null,"jensenScore":6.459687,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.25882824771007,"pubTatorScore":1.9134732319692482,"self":"https://pharos.nih.gov/idg/api/v1/targets(14476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(14476)/publications"},"_namespace":null},{"id":14477,"version":3,"created":1554975380000,"modified":1555042041000,"deprecated":false,"name":"P-selectin glycoprotein ligand 1","accession":"Q14242","gene":"SELPLG","description":"(Microbial infection) Acts as a receptor for enterovirus 71.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7698884265008656,"antibodyCount":626,"monoclonalCount":391,"pubmedCount":null,"jensenScore":605.846724,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.88796478664111,"pubTatorScore":2.812912726581327,"self":"https://pharos.nih.gov/idg/api/v1/targets(14477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/synonyms"},"_publications":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(14477)/publications"},"_namespace":null},{"id":14478,"version":2,"created":1554975387000,"modified":1554975390000,"deprecated":false,"name":"Endonuclease G, mitochondrial","accession":"Q14249","gene":"ENDOG","description":"Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2279145785280057,"antibodyCount":334,"monoclonalCount":95,"pubmedCount":null,"jensenScore":175.852292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.58677701856338,"pubTatorScore":2.0375318712942025,"self":"https://pharos.nih.gov/idg/api/v1/targets(14478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(14478)/publications"},"_namespace":null},{"id":14479,"version":2,"created":1554975391000,"modified":1554975395000,"deprecated":false,"name":"Transmembrane protein 50B","accession":"P56557","gene":"TMEM50B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3197503022236352,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.96738,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.237095349424685,"pubTatorScore":-0.07748162063726477,"self":"https://pharos.nih.gov/idg/api/v1/targets(14479)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(14479)/publications"},"_namespace":null},{"id":14480,"version":3,"created":1554975396000,"modified":1555042043000,"deprecated":false,"name":"Src substrate cortactin","accession":"Q14247","gene":"CTTN","description":"Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). 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Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. 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Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2325725806264844,"antibodyCount":119,"monoclonalCount":4,"pubmedCount":null,"jensenScore":18.249816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.021973568009827,"pubTatorScore":1.143881804602326,"self":"https://pharos.nih.gov/idg/api/v1/targets(14544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(14544)/publications"},"_namespace":null},{"id":14545,"version":2,"created":1554975730000,"modified":1554975735000,"deprecated":false,"name":"Transmembrane protein 150C","accession":"B9EJG8","gene":"TMEM150C","description":"Component of a mechanosensitive cation channel. 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Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.3282376763515174,"antibodyCount":90,"monoclonalCount":4,"pubmedCount":null,"jensenScore":1.804249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.237729767542273,"pubTatorScore":0.15062843456746924,"self":"https://pharos.nih.gov/idg/api/v1/targets(14546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(14546)/publications"},"_namespace":null},{"id":14547,"version":2,"created":1554975740000,"modified":1554975743000,"deprecated":false,"name":"Angiomotin","accession":"Q4VCS5","gene":"AMOT","description":"Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. 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Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.931050155381126,"antibodyCount":560,"monoclonalCount":125,"pubmedCount":null,"jensenScore":922.425159,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":52.68108703071826,"pubTatorScore":2.881603512287583,"self":"https://pharos.nih.gov/idg/api/v1/targets(14550)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/properties"},"_links":{"count":1292,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/links"},"_synonyms":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/synonyms"},"_publications":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(14550)/publications"},"_namespace":null},{"id":14551,"version":2,"created":1554975964000,"modified":1554975966000,"deprecated":false,"name":"Retina and anterior neural fold homeobox protein 2","accession":"Q96IS3","gene":"RAX2","description":"May be involved in modulating the expression of photoreceptor specific genes. 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Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). 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Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. 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Binds to LGALS3 at the maternal-fetal interface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.188420972902821,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":160.999561,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.41146385108075,"pubTatorScore":2.055399609754129,"self":"https://pharos.nih.gov/idg/api/v1/targets(14654)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(14654)/publications"},"_namespace":null},{"id":14655,"version":3,"created":1554977062000,"modified":1554977159000,"deprecated":false,"name":"Glucagon-like peptide 1 receptor","accession":"P43220","gene":"GLP1R","description":"G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.9205944264163497,"antibodyCount":306,"monoclonalCount":38,"pubmedCount":null,"jensenScore":820.537935,"patentCount":21409,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.031878799868995,"pubTatorScore":2.928823700619351,"self":"https://pharos.nih.gov/idg/api/v1/targets(14655)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/synonyms"},"_publications":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(14655)/publications"},"_namespace":null},{"id":14656,"version":2,"created":1554977161000,"modified":1554977162000,"deprecated":false,"name":"Aquaporin-12B","accession":"A6NM10","gene":"AQP12B","description":"Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9513774851947907,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.845799,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.094502463123787,"pubTatorScore":-0.33881887240402814,"self":"https://pharos.nih.gov/idg/api/v1/targets(14656)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/properties"},"_links":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(14656)/publications"},"_namespace":null},{"id":14657,"version":3,"created":1554977162000,"modified":1555042161000,"deprecated":false,"name":"Sorting nexin-3","accession":"O60493","gene":"SNX3","description":"Phosphoinositide-binding protein required for multivesicular body formation. 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Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3422968231479846,"antibodyCount":225,"monoclonalCount":22,"pubmedCount":null,"jensenScore":23.532681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.650619945405836,"pubTatorScore":1.2918500378480666,"self":"https://pharos.nih.gov/idg/api/v1/targets(14657)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(14657)/publications"},"_namespace":null},{"id":14658,"version":2,"created":1554977167000,"modified":1554977169000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 37A2","accession":"A6NM11","gene":"LRRC37A2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2509511318514679,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.46978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.633698331214951,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(14658)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(14658)/publications"},"_namespace":null},{"id":14659,"version":2,"created":1554977170000,"modified":1554977174000,"deprecated":false,"name":"Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase","accession":"Q96IV0","gene":"NGLY1","description":"Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. 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Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9261475338408427,"antibodyCount":32,"monoclonalCount":2,"pubmedCount":null,"jensenScore":77.4055,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.5625172992021,"pubTatorScore":2.1461078001860665,"self":"https://pharos.nih.gov/idg/api/v1/targets(14659)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(14659)/publications"},"_namespace":null},{"id":14660,"version":2,"created":1554977174000,"modified":1554977175000,"deprecated":false,"name":"Protein SPHAR","accession":"Q15513","gene":"SPHAR","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0440168087172985,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.783521,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.251524305581867,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(14660)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/properties"},"_links":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(14660)/publications"},"_namespace":null},{"id":14661,"version":2,"created":1554977175000,"modified":1554977180000,"deprecated":false,"name":"Calcium-independent phospholipase A2-gamma","accession":"Q9NP80","gene":"PNPLA8","description":"Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. 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Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.889093942299386,"antibodyCount":217,"monoclonalCount":37,"pubmedCount":null,"jensenScore":755.511785,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":29.404438585495924,"pubTatorScore":2.778329617580642,"self":"https://pharos.nih.gov/idg/api/v1/targets(14663)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(14663)/publications"},"_namespace":null},{"id":14664,"version":3,"created":1554977193000,"modified":1555042166000,"deprecated":false,"name":"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2","accession":"Q16842","gene":"ST3GAL2","description":"Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. 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Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.070524875106741,"antibodyCount":2150,"monoclonalCount":488,"pubmedCount":null,"jensenScore":1137.418473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":69.73951691819548,"pubTatorScore":3.506345550350962,"self":"https://pharos.nih.gov/idg/api/v1/targets(14800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1522,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/properties"},"_links":{"count":1882,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/links"},"_synonyms":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/synonyms"},"_publications":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(14800)/publications"},"_namespace":null},{"id":14801,"version":2,"created":1554978264000,"modified":1554978268000,"deprecated":false,"name":"Twisted gastrulation protein homolog 1","accession":"Q9GZX9","gene":"TWSG1","description":"May be involved in dorsoventral axis formation. 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May play a role in thymocyte development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.472091827443325,"antibodyCount":79,"monoclonalCount":43,"pubmedCount":null,"jensenScore":291.948333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.53946330715206,"pubTatorScore":1.8381888769631118,"self":"https://pharos.nih.gov/idg/api/v1/targets(14801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(14801)/publications"},"_namespace":null},{"id":14802,"version":2,"created":1554978269000,"modified":1554978273000,"deprecated":false,"name":"SUMO-activating enzyme subunit 1","accession":"Q9UBE0","gene":"SAE1","description":"The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. 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At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.317362220290323,"antibodyCount":260,"monoclonalCount":41,"pubmedCount":null,"jensenScore":223.472836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.66547450830746,"pubTatorScore":2.2032548021362772,"self":"https://pharos.nih.gov/idg/api/v1/targets(14809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":589,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/synonyms"},"_publications":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(14809)/publications"},"_namespace":null},{"id":14810,"version":2,"created":1554978305000,"modified":1554978305000,"deprecated":false,"name":"Putative gap junction epsilon-1 protein","accession":"A6NN92","gene":"GJE1","description":"Mediates calcium-independent ATP release, suggesting activity as a hemichannel. 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May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.851526912589436,"antibodyCount":302,"monoclonalCount":68,"pubmedCount":null,"jensenScore":635.262725,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.810967728906476,"pubTatorScore":3.815575014053383,"self":"https://pharos.nih.gov/idg/api/v1/targets(14812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/synonyms"},"_publications":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(14812)/publications"},"_namespace":null},{"id":14813,"version":3,"created":1554978312000,"modified":1555042250000,"deprecated":false,"name":"Carbohydrate sulfotransferase 6","accession":"Q9GZX3","gene":"CHST6","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. 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May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. 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Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3256481913451006,"antibodyCount":128,"monoclonalCount":36,"pubmedCount":null,"jensenScore":21.65909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.39930299773658,"pubTatorScore":2.2052087935126647,"self":"https://pharos.nih.gov/idg/api/v1/targets(14860)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(14860)/publications"},"_namespace":null},{"id":14861,"version":2,"created":1554978652000,"modified":1554978652000,"deprecated":false,"name":"Olfactory receptor 4C45","accession":"A6NMZ5","gene":"OR4C45","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.921718895272711,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(14861)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(14861)/publications"},"_namespace":null},{"id":14862,"version":2,"created":1554978652000,"modified":1554978654000,"deprecated":false,"name":"Zinc finger protein 613","accession":"Q6PF04","gene":"ZNF613","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":88,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.55139462223416,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(14862)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(14862)/publications"},"_namespace":null},{"id":14863,"version":4,"created":1554978655000,"modified":1555042286000,"deprecated":false,"name":"Casein kinase II subunit alpha'","accession":"P19784","gene":"CSNK2A2","description":"Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. 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Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.341677549924326,"antibodyCount":218,"monoclonalCount":36,"pubmedCount":null,"jensenScore":221.259226,"patentCount":7051,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":46.92641101964884,"pubTatorScore":1.416171015943221,"self":"https://pharos.nih.gov/idg/api/v1/targets(14863)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":516,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/synonyms"},"_publications":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(14863)/publications"},"_namespace":null},{"id":14864,"version":2,"created":1554978694000,"modified":1554978700000,"deprecated":false,"name":"Methyl-CpG-binding domain protein 4","accession":"O95243","gene":"MBD4","description":"Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.996252618074547,"antibodyCount":183,"monoclonalCount":3,"pubmedCount":null,"jensenScore":98.642614,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.544413343713124,"pubTatorScore":1.88954997512218,"self":"https://pharos.nih.gov/idg/api/v1/targets(14864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/properties"},"_links":{"count":1082,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(14864)/publications"},"_namespace":null},{"id":14865,"version":2,"created":1554978701000,"modified":1554978706000,"deprecated":false,"name":"Ammonium transporter Rh type A","accession":"Q02094","gene":"RHAG","description":"Associated with rhesus blood group antigen expression (PubMed:19744193). May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane (PubMed:11062476, PubMed:11861637). Involved in ammonia transport across the erythrocyte membrane (PubMed:21849667, PubMed:22012326). 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Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (PubMed:20457893). Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation (PubMed:20457893). In a complex with coregulator RCCD1, is also able to demethylate trimethylated 'Lys-36' (H3K36me3) of histone H3 (PubMed:24981860). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1 (PubMed:24981860). Possibly together with RCCD1, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability (PubMed:28455245). Might function as a protein hydroxylase (PubMed:22851697, PubMed:24100311). Under stress conditions that cause a DNA damage response, acts as a histone protease by cleaving the N-terminal tail of histone H3 at the carboxyl side of monomethyl-lysine (Kme1) residues, preferably at monomethylated 'Lys-9' (H3K9me1) (PubMed:28982940). The histone variant H3F3A is the major target for cleavage (PubMed:28982940).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.6820053641650512,"antibodyCount":209,"monoclonalCount":17,"pubmedCount":null,"jensenScore":49.631656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.85232522083663,"pubTatorScore":1.1075092243512528,"self":"https://pharos.nih.gov/idg/api/v1/targets(14868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(14868)/publications"},"_namespace":null},{"id":14869,"version":2,"created":1554978719000,"modified":1554978726000,"deprecated":false,"name":"Collagen alpha-6(VI) chain","accession":"A6NMZ7","gene":"COL6A6","description":"Collagen VI acts as a cell-binding protein.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.48745262289592867,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.275,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.413633842533265,"pubTatorScore":0.15103534228890542,"self":"https://pharos.nih.gov/idg/api/v1/targets(14869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(14869)/publications"},"_namespace":null},{"id":14870,"version":2,"created":1554978727000,"modified":1554978732000,"deprecated":false,"name":"ADP/ATP translocase 2","accession":"P05141","gene":"SLC25A5","description":"Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. 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May be involved in muscle-specific and/or growth factor-related transcription.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.390107235869541,"antibodyCount":113,"monoclonalCount":41,"pubmedCount":null,"jensenScore":19.976941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(14873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(14873)/publications"},"_namespace":null},{"id":14874,"version":3,"created":1554978742000,"modified":1555042289000,"deprecated":false,"name":"T-cell surface glycoprotein CD3 epsilon chain","accession":"P07766","gene":"CD3E","description":"Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.2521564430517054,"antibodyCount":2406,"monoclonalCount":1819,"pubmedCount":null,"jensenScore":172.570359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.13467090311029,"pubTatorScore":2.2871060444133247,"self":"https://pharos.nih.gov/idg/api/v1/targets(14874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/synonyms"},"_publications":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(14874)/publications"},"_namespace":null},{"id":14875,"version":2,"created":1554978746000,"modified":1554978761000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily H member 1","accession":"O95259","gene":"KCNH1","description":"Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.8611133710870855,"antibodyCount":150,"monoclonalCount":6,"pubmedCount":null,"jensenScore":714.162763,"patentCount":19282,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.21170359721087,"pubTatorScore":2.3460585325537284,"self":"https://pharos.nih.gov/idg/api/v1/targets(14875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(14875)/publications"},"_namespace":null},{"id":14876,"version":3,"created":1554978762000,"modified":1555042290000,"deprecated":false,"name":"Interleukin-18 receptor accessory protein","accession":"O95256","gene":"IL18RAP","description":"Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5309273833457395,"antibodyCount":249,"monoclonalCount":72,"pubmedCount":null,"jensenScore":27.625909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.934326652022055,"pubTatorScore":1.5515448980268483,"self":"https://pharos.nih.gov/idg/api/v1/targets(14876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/properties"},"_links":{"count":804,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(14876)/publications"},"_namespace":null},{"id":14877,"version":3,"created":1554978767000,"modified":1555042292000,"deprecated":false,"name":"Integrin beta-3","accession":"P05106","gene":"ITGB3","description":"(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB3 acts as a receptor for coxsackievirus A9 (PubMed:7519807). Acts as a receptor for Hantaan virus (PubMed:9618541). Integrin ITGAV:ITGB3 acts as a receptor for cytomegalovirus/HHV-5 (PubMed:15834425). Integrin ITGA5:ITGB3 acts as a receptor for human metapneumovirus (PubMed:24478423). Integrin ITGAV:ITGB3 acts aP05556s a receptor for human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for west nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.04474531717982,"antibodyCount":1517,"monoclonalCount":879,"pubmedCount":null,"jensenScore":986.940542,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":58.464467164929005,"pubTatorScore":3.05104647988221,"self":"https://pharos.nih.gov/idg/api/v1/targets(14877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1520,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/properties"},"_links":{"count":1792,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/links"},"_synonyms":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/synonyms"},"_publications":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(14877)/publications"},"_namespace":null},{"id":14878,"version":3,"created":1554978781000,"modified":1555042297000,"deprecated":false,"name":"Integrin beta-2","accession":"P05107","gene":"ITGB2","description":"Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.4040487789863554,"antibodyCount":1411,"monoclonalCount":970,"pubmedCount":null,"jensenScore":232.107205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":51.577807103146164,"pubTatorScore":3.095597565306178,"self":"https://pharos.nih.gov/idg/api/v1/targets(14878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":841,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/properties"},"_links":{"count":1427,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/links"},"_synonyms":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/synonyms"},"_publications":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(14878)/publications"},"_namespace":null},{"id":14879,"version":3,"created":1554978792000,"modified":1555042300000,"deprecated":false,"name":"Growth arrest and DNA damage-inducible protein GADD45 gamma","accession":"O95257","gene":"GADD45G","description":"Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4544442561660955,"antibodyCount":567,"monoclonalCount":362,"pubmedCount":null,"jensenScore":286.799255,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.22967948842283,"pubTatorScore":1.6018044858832998,"self":"https://pharos.nih.gov/idg/api/v1/targets(14879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(14879)/publications"},"_namespace":null},{"id":14880,"version":3,"created":1554978795000,"modified":1555042302000,"deprecated":false,"name":"Cholesterol side-chain cleavage enzyme, mitochondrial","accession":"P05108","gene":"CYP11A1","description":"Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.936561552246959,"antibodyCount":296,"monoclonalCount":4,"pubmedCount":null,"jensenScore":785.324204,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.583463911571066,"pubTatorScore":2.7593251546506203,"self":"https://pharos.nih.gov/idg/api/v1/targets(14880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(14880)/publications"},"_namespace":null},{"id":14881,"version":3,"created":1554978809000,"modified":1555042303000,"deprecated":false,"name":"Protein S100-A8","accession":"P05109","gene":"S100A8","description":"S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. 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