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During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.584075587028835,"antibodyCount":781,"monoclonalCount":230,"pubmedCount":null,"jensenScore":4276.69231,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":39.33724713249712,"pubTatorScore":3.29036038350468,"self":"https://pharos.nih.gov/idg/api/v1/targets(13055)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(13055)/properties"},"_links":{"count":1244,"href":"https://pharos.nih.gov/idg/api/v1/targets(13055)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(13055)/synonyms"},"_publications":{"count":541,"href":"https://pharos.nih.gov/idg/api/v1/targets(13055)/publications"},"_namespace":null},{"id":13056,"version":2,"created":1554961645000,"modified":1554961649000,"deprecated":false,"name":"Transportin-2","accession":"O14787","gene":"TNPO2","description":"Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0157942736172243,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.794052,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.76967714326214,"pubTatorScore":0.9672085978852097,"self":"https://pharos.nih.gov/idg/api/v1/targets(13056)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(13056)/properties"},"_links":{"count":1110,"href":"https://pharos.nih.gov/idg/api/v1/targets(13056)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13056)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(13056)/publications"},"_namespace":null},{"id":13057,"version":3,"created":1554961650000,"modified":1555041119000,"deprecated":false,"name":"Protein TFG","accession":"Q92734","gene":"TFG","description":"Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3145001009059376,"antibodyCount":200,"monoclonalCount":30,"pubmedCount":null,"jensenScore":187.435798,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":42.57773712478552,"pubTatorScore":1.7343219548138367,"self":"https://pharos.nih.gov/idg/api/v1/targets(13057)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(13057)/properties"},"_links":{"count":1175,"href":"https://pharos.nih.gov/idg/api/v1/targets(13057)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(13057)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(13057)/publications"},"_namespace":null},{"id":13058,"version":3,"created":1554961656000,"modified":1555041120000,"deprecated":false,"name":"Proline-rich protein PRCC","accession":"Q92733","gene":"PRCC","description":"May regulate cell cycle progression through interaction with MAD2L2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1175397856503992,"antibodyCount":43,"monoclonalCount":3,"pubmedCount":null,"jensenScore":119.619511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":36.56448306319308,"pubTatorScore":2.071601616528695,"self":"https://pharos.nih.gov/idg/api/v1/targets(13058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(13058)/properties"},"_links":{"count":1093,"href":"https://pharos.nih.gov/idg/api/v1/targets(13058)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(13058)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(13058)/publications"},"_namespace":null},{"id":13059,"version":2,"created":1554961661000,"modified":1554961663000,"deprecated":false,"name":"Transcription factor AP-2-delta","accession":"Q7Z6R9","gene":"TFAP2D","description":"Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. 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Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2634258319232137,"antibodyCount":600,"monoclonalCount":60,"pubmedCount":null,"jensenScore":183.366096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.76224986681189,"pubTatorScore":2.20283065626373,"self":"https://pharos.nih.gov/idg/api/v1/targets(13099)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(13099)/properties"},"_links":{"count":1269,"href":"https://pharos.nih.gov/idg/api/v1/targets(13099)/links"},"_synonyms":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(13099)/synonyms"},"_publications":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(13099)/publications"},"_namespace":null},{"id":13100,"version":2,"created":1554961818000,"modified":1554961823000,"deprecated":false,"name":"Potassium channel subfamily K member 1","accession":"O00180","gene":"KCNK1","description":"Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). 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Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. 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Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.5691029509727423,"antibodyCount":643,"monoclonalCount":47,"pubmedCount":null,"jensenScore":3506.357906,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.64638326675218,"pubTatorScore":3.5508863349590136,"self":"https://pharos.nih.gov/idg/api/v1/targets(13119)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1886,"href":"https://pharos.nih.gov/idg/api/v1/targets(13119)/properties"},"_links":{"count":2650,"href":"https://pharos.nih.gov/idg/api/v1/targets(13119)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(13119)/synonyms"},"_publications":{"count":1495,"href":"https://pharos.nih.gov/idg/api/v1/targets(13119)/publications"},"_namespace":null},{"id":13120,"version":2,"created":1554961976000,"modified":1554961978000,"deprecated":false,"name":"Synapsin-2","accession":"Q92777","gene":"SYN2","description":"Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. 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Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-3.11678728368974,"antibodyCount":249,"monoclonalCount":92,"pubmedCount":null,"jensenScore":1295.925248,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.59366351454753,"pubTatorScore":2.3434199818209627,"self":"https://pharos.nih.gov/idg/api/v1/targets(13121)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":630,"href":"https://pharos.nih.gov/idg/api/v1/targets(13121)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(13121)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(13121)/synonyms"},"_publications":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(13121)/publications"},"_namespace":null},{"id":13122,"version":2,"created":1554961984000,"modified":1554961985000,"deprecated":false,"name":"Folate transporter-like protein C2orf83","accession":"Q53S99","gene":"C2orf83","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13122)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(13122)/properties"},"_links":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(13122)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(13122)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13122)/publications"},"_namespace":null},{"id":13123,"version":2,"created":1554961985000,"modified":1554961989000,"deprecated":false,"name":"Cytochrome c oxidase subunit 5B, mitochondrial","accession":"P10606","gene":"COX5B","description":"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5473571765356064,"antibodyCount":253,"monoclonalCount":38,"pubmedCount":null,"jensenScore":33.444228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.05110338225797,"pubTatorScore":1.0723782547684637,"self":"https://pharos.nih.gov/idg/api/v1/targets(13123)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(13123)/properties"},"_links":{"count":1144,"href":"https://pharos.nih.gov/idg/api/v1/targets(13123)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13123)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(13123)/publications"},"_namespace":null},{"id":13124,"version":2,"created":1554961990000,"modified":1554961994000,"deprecated":false,"name":"Zinc finger protein 91","accession":"Q05481","gene":"ZNF91","description":"Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). 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Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-2.796512919627251,"antibodyCount":712,"monoclonalCount":109,"pubmedCount":null,"jensenScore":587.852669,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":55.413053199478945,"pubTatorScore":2.5726385139643093,"self":"https://pharos.nih.gov/idg/api/v1/targets(13125)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(13125)/properties"},"_links":{"count":2018,"href":"https://pharos.nih.gov/idg/api/v1/targets(13125)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(13125)/synonyms"},"_publications":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(13125)/publications"},"_namespace":null},{"id":13126,"version":2,"created":1554962050000,"modified":1554962052000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 19","accession":"Q9H756","gene":"LRRC19","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4856538359768698,"antibodyCount":109,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.630953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.97705936919034,"pubTatorScore":0.290034611362518,"self":"https://pharos.nih.gov/idg/api/v1/targets(13126)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(13126)/properties"},"_links":{"count":709,"href":"https://pharos.nih.gov/idg/api/v1/targets(13126)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(13126)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(13126)/publications"},"_namespace":null},{"id":13127,"version":4,"created":1554962052000,"modified":1555041167000,"deprecated":false,"name":"Platelet-derived growth factor receptor beta","accession":"P09619","gene":"PDGFRB","description":"Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. 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Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.8931498294698508,"antibodyCount":1390,"monoclonalCount":464,"pubmedCount":null,"jensenScore":712.306346,"patentCount":175967,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":56.469164804192175,"pubTatorScore":2.9764321400221965,"self":"https://pharos.nih.gov/idg/api/v1/targets(13127)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(13127)/properties"},"_links":{"count":1822,"href":"https://pharos.nih.gov/idg/api/v1/targets(13127)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(13127)/synonyms"},"_publications":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(13127)/publications"},"_namespace":null},{"id":13128,"version":2,"created":1554962141000,"modified":1554962142000,"deprecated":false,"name":"Putative transcription factor ovo-like protein 3","accession":"O00110","gene":"OVOL3","description":"May act as a transcription regulator.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.585500581028687,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(13128)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(13128)/properties"},"_links":{"count":656,"href":"https://pharos.nih.gov/idg/api/v1/targets(13128)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(13128)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(13128)/publications"},"_namespace":null},{"id":13129,"version":2,"created":1554962143000,"modified":1554962146000,"deprecated":false,"name":"Membralin","accession":"Q4ZIN3","gene":"TMEM259","description":"May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). 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Plays a role in spermiogenesis and oogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.6020599913279624,"antibodyCount":80,"monoclonalCount":11,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.09765529462975,"pubTatorScore":1.1861765883977378,"self":"https://pharos.nih.gov/idg/api/v1/targets(13171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(13171)/publications"},"_namespace":null},{"id":13172,"version":3,"created":1554962726000,"modified":1555041192000,"deprecated":false,"name":"Coiled-coil domain-containing protein 40","accession":"Q4G0X9","gene":"CCDC40","description":"Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). 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Required for axonemal recruitment of CCDC39 (PubMed:21131974).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8982644020246348,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.802858,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":33.47720066590593,"pubTatorScore":0.8050808371163336,"self":"https://pharos.nih.gov/idg/api/v1/targets(13172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13172)/publications"},"_namespace":null},{"id":13173,"version":3,"created":1554962731000,"modified":1555041194000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 10B","accession":"O14763","gene":"TNFRSF10B","description":"Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). 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Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8840638064127406,"antibodyCount":269,"monoclonalCount":60,"pubmedCount":null,"jensenScore":72.742422,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.30680688782163,"pubTatorScore":1.739073774680865,"self":"https://pharos.nih.gov/idg/api/v1/targets(13177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(13177)/publications"},"_namespace":null},{"id":13178,"version":3,"created":1554962756000,"modified":1555041200000,"deprecated":false,"name":"Kinesin-like protein KIF2A","accession":"O00139","gene":"KIF2A","description":"Plus end-directed microtubule-dependent motor required for normal brain development. 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May modulate the transcription factor activity of THRB.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3782246389870854,"antibodyCount":105,"monoclonalCount":10,"pubmedCount":null,"jensenScore":221.459116,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":37,"knowledgeAvailability":23.532118517354526,"pubTatorScore":1.5402996488747827,"self":"https://pharos.nih.gov/idg/api/v1/targets(13179)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(13179)/publications"},"_namespace":null},{"id":13180,"version":3,"created":1554962766000,"modified":1555041203000,"deprecated":false,"name":"Actin-related 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Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-4.451487743658965,"antibodyCount":1170,"monoclonalCount":801,"pubmedCount":null,"jensenScore":28259.401596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":34,"knowledgeAvailability":37.14636028240179,"pubTatorScore":3.1275961727489023,"self":"https://pharos.nih.gov/idg/api/v1/targets(13185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(13185)/properties"},"_links":{"count":1229,"href":"https://pharos.nih.gov/idg/api/v1/targets(13185)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(13185)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(13185)/publications"},"_namespace":null},{"id":13186,"version":3,"created":1554962796000,"modified":1555041210000,"deprecated":false,"name":"Putative ATP-dependent RNA helicase DHX33","accession":"Q9H6R0","gene":"DHX33","description":"Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.710600858675337,"antibodyCount":33,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.826504,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.777161762729122,"pubTatorScore":0.7444792594137285,"self":"https://pharos.nih.gov/idg/api/v1/targets(13186)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(13186)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(13186)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(13186)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(13186)/publications"},"_namespace":null},{"id":13187,"version":2,"created":1554962799000,"modified":1554962803000,"deprecated":false,"name":"Acyl-CoA synthetase short-chain family member 3, mitochondrial","accession":"Q9H6R3","gene":"ACSS3","description":"Activates acetate so that it can be used for lipid synthesis or for energy generation.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5414923833139487,"antibodyCount":84,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.909096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.430751136019527,"pubTatorScore":0.15970070923842,"self":"https://pharos.nih.gov/idg/api/v1/targets(13187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(13187)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(13187)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(13187)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13187)/publications"},"_namespace":null},{"id":13188,"version":3,"created":1554962804000,"modified":1555041215000,"deprecated":false,"name":"Cell cycle control protein 50B","accession":"Q3MIR4","gene":"TMEM30B","description":"Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3897987069891936,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.672598,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":78,"knowledgeAvailability":22.22808775713613,"pubTatorScore":0.42255340091733223,"self":"https://pharos.nih.gov/idg/api/v1/targets(13188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(13188)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(13188)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(13188)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13188)/publications"},"_namespace":null},{"id":13189,"version":2,"created":1554962808000,"modified":1554962808000,"deprecated":false,"name":"Coiled-coil domain-containing protein 144B","accession":"Q3MJ40","gene":"CCDC144B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.511013391161812,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13189)/properties"},"_links":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(13189)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(13189)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(13189)/publications"},"_namespace":null},{"id":13190,"version":2,"created":1554962808000,"modified":1554962810000,"deprecated":false,"name":"WD repeat-containing protein 74","accession":"Q6RFH5","gene":"WDR74","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9450991196849613,"antibodyCount":124,"monoclonalCount":43,"pubmedCount":null,"jensenScore":9.300367,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.380094183298056,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(13190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(13190)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(13190)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13190)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13190)/publications"},"_namespace":null},{"id":13191,"version":2,"created":1554962811000,"modified":1554962813000,"deprecated":false,"name":"Dual specificity phosphatase 28","accession":"Q4G0W2","gene":"DUSP28","description":"Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9704579569053866,"antibodyCount":20,"monoclonalCount":7,"pubmedCount":null,"jensenScore":88.722862,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.484942641510056,"pubTatorScore":0.5740312677277188,"self":"https://pharos.nih.gov/idg/api/v1/targets(13191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(13191)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(13191)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(13191)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(13191)/publications"},"_namespace":null},{"id":13192,"version":2,"created":1554962814000,"modified":1554962818000,"deprecated":false,"name":"E3 ubiquitin-protein ligase MARCH8","accession":"Q5T0T0","gene":"MARCH8","description":"E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6814026859540838,"antibodyCount":119,"monoclonalCount":9,"pubmedCount":null,"jensenScore":46.877039,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.011074305715695,"pubTatorScore":0.9350591370289841,"self":"https://pharos.nih.gov/idg/api/v1/targets(13192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13192)/publications"},"_namespace":null},{"id":13193,"version":3,"created":1554962819000,"modified":1555041216000,"deprecated":false,"name":"Serine/threonine-protein kinase Sgk1","accession":"O00141","gene":"SGK1","description":"Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.679789301780927,"antibodyCount":642,"monoclonalCount":108,"pubmedCount":null,"jensenScore":543.652742,"patentCount":31010,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":58.65547563268133,"pubTatorScore":2.4635908582220396,"self":"https://pharos.nih.gov/idg/api/v1/targets(13193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":678,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/properties"},"_links":{"count":1459,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/synonyms"},"_publications":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(13193)/publications"},"_namespace":null},{"id":13194,"version":3,"created":1554962844000,"modified":1555041219000,"deprecated":false,"name":"Tripeptidyl-peptidase 1","accession":"O14773","gene":"TPP1","description":"Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1832345478331034,"antibodyCount":273,"monoclonalCount":56,"pubmedCount":null,"jensenScore":155.212345,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":44.98095208915767,"pubTatorScore":2.3768826985626097,"self":"https://pharos.nih.gov/idg/api/v1/targets(13194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/properties"},"_links":{"count":1205,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/synonyms"},"_publications":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(13194)/publications"},"_namespace":null},{"id":13195,"version":2,"created":1554962850000,"modified":1554962853000,"deprecated":false,"name":"Fucose-1-phosphate guanylyltransferase","accession":"O14772","gene":"FPGT","description":"Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1287222982358505,"antibodyCount":112,"monoclonalCount":3,"pubmedCount":null,"jensenScore":12.890584,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.055562359042842,"pubTatorScore":0.9344984512435677,"self":"https://pharos.nih.gov/idg/api/v1/targets(13195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(13195)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(13195)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(13195)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13195)/publications"},"_namespace":null},{"id":13196,"version":3,"created":1554962854000,"modified":1555041220000,"deprecated":false,"name":"Zona pellucida-binding protein 2","accession":"Q6X784","gene":"ZPBP2","description":"Is implicated in sperm-oocyte interaction during fertilization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0029239367890972,"antibodyCount":53,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.575626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":24.45832127133116,"pubTatorScore":0.880586728458538,"self":"https://pharos.nih.gov/idg/api/v1/targets(13196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(13196)/properties"},"_links":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(13196)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(13196)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(13196)/publications"},"_namespace":null},{"id":13197,"version":3,"created":1554962856000,"modified":1555041221000,"deprecated":false,"name":"Guanine nucleotide-binding protein subunit beta-5","accession":"O14775","gene":"GNB5","description":"Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9249631779295664,"antibodyCount":222,"monoclonalCount":20,"pubmedCount":null,"jensenScore":86.862606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.36605946914393,"pubTatorScore":1.6488399680161807,"self":"https://pharos.nih.gov/idg/api/v1/targets(13197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(13197)/publications"},"_namespace":null},{"id":13198,"version":3,"created":1554962861000,"modified":1555041222000,"deprecated":false,"name":"Kinetochore protein NDC80 homolog","accession":"O14777","gene":"NDC80","description":"Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4512360338992587,"antibodyCount":300,"monoclonalCount":62,"pubmedCount":null,"jensenScore":265.15585,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.21204605240898,"pubTatorScore":2.3053244681552685,"self":"https://pharos.nih.gov/idg/api/v1/targets(13198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13198)/publications"},"_namespace":null},{"id":13199,"version":3,"created":1554962867000,"modified":1555041224000,"deprecated":false,"name":"Heme oxygenase 1","accession":"P09601","gene":"HMOX1","description":"Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. 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May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.39731914013806996,"antibodyCount":59,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.687645,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.85402033579902,"pubTatorScore":0.14754926292833342,"self":"https://pharos.nih.gov/idg/api/v1/targets(13218)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13218)/publications"},"_namespace":null},{"id":13219,"version":2,"created":1554962955000,"modified":1554962957000,"deprecated":false,"name":"RANBP2-like and GRIP domain-containing protein 8","accession":"O14715","gene":"RGPD8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4966661244925651,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.496743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.894047261852315,"pubTatorScore":0.10833936198506207,"self":"https://pharos.nih.gov/idg/api/v1/targets(13219)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13219)/publications"},"_namespace":null},{"id":13220,"version":2,"created":1554962958000,"modified":1554962961000,"deprecated":false,"name":"tRNA (cytosine(38)-C(5))-methyltransferase","accession":"O14717","gene":"TRDMT1","description":"Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9962814667684947,"antibodyCount":337,"monoclonalCount":72,"pubmedCount":null,"jensenScore":94.902178,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.89706684980281,"pubTatorScore":1.6852204695177713,"self":"https://pharos.nih.gov/idg/api/v1/targets(13220)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(13220)/publications"},"_namespace":null},{"id":13221,"version":2,"created":1554962962000,"modified":1554962965000,"deprecated":false,"name":"Visual pigment-like receptor peropsin","accession":"O14718","gene":"RRH","description":"May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.6359982700450397,"antibodyCount":112,"monoclonalCount":0,"pubmedCount":null,"jensenScore":41.722642,"patentCount":2613,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.524441021305126,"pubTatorScore":1.312243151725746,"self":"https://pharos.nih.gov/idg/api/v1/targets(13221)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(13221)/publications"},"_namespace":null},{"id":13222,"version":2,"created":1554962965000,"modified":1554962969000,"deprecated":false,"name":"tRNA-splicing endonuclease subunit Sen54","accession":"Q7Z6J9","gene":"TSEN54","description":"Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. 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Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2312794128302602,"antibodyCount":138,"monoclonalCount":56,"pubmedCount":null,"jensenScore":20.778149,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.86089307267551,"pubTatorScore":1.2273152444098903,"self":"https://pharos.nih.gov/idg/api/v1/targets(13224)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(13224)/publications"},"_namespace":null},{"id":13225,"version":3,"created":1554962978000,"modified":1555041232000,"deprecated":false,"name":"Zinc finger protein 524","accession":"Q96C55","gene":"ZNF524","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":61,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":25.369280776693078,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13225)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(13225)/publications"},"_namespace":null},{"id":13226,"version":2,"created":1554962981000,"modified":1554962982000,"deprecated":false,"name":"Uncharacterized protein C12orf43","accession":"Q96C57","gene":"C12orf43","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13226)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(13226)/publications"},"_namespace":null},{"id":13227,"version":2,"created":1554962983000,"modified":1554962987000,"deprecated":false,"name":"Alkylated DNA repair protein alkB homolog 8","accession":"Q96BT7","gene":"ALKBH8","description":"Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). 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May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2683346155886008,"antibodyCount":107,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.038417,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.641947741624485,"pubTatorScore":1.0414866405276861,"self":"https://pharos.nih.gov/idg/api/v1/targets(13227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(13227)/publications"},"_namespace":null},{"id":13228,"version":2,"created":1554962987000,"modified":1554962989000,"deprecated":false,"name":"Putative uncharacterized protein C3orf49","accession":"Q96BT1","gene":"C3orf49","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/properties"},"_links":{"count":675,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(13228)/publications"},"_namespace":null},{"id":13229,"version":2,"created":1554962989000,"modified":1554962993000,"deprecated":false,"name":"Rho GTPase-activating protein 30","accession":"Q7Z6I6","gene":"ARHGAP30","description":"GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.047923551376211425,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.236842,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.970813401435155,"pubTatorScore":0.1879905762568884,"self":"https://pharos.nih.gov/idg/api/v1/targets(13229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13229)/publications"},"_namespace":null},{"id":13230,"version":2,"created":1554962994000,"modified":1554962997000,"deprecated":false,"name":"Centromere protein T","accession":"Q96BT3","gene":"CENPT","description":"Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. 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Required for normal chromosome organization and normal progress through mitosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1951086010235834,"antibodyCount":69,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.432522,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.38148209845784,"pubTatorScore":1.1161252365208771,"self":"https://pharos.nih.gov/idg/api/v1/targets(13230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/properties"},"_links":{"count":962,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(13230)/publications"},"_namespace":null},{"id":13231,"version":2,"created":1554962998000,"modified":1554962999000,"deprecated":false,"name":"Putative ubiquitin carboxyl-terminal hydrolase 41","accession":"Q3LFD5","gene":"USP41","description":"May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. 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Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3856700561636346,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":23.949457,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6823527837864158,"self":"https://pharos.nih.gov/idg/api/v1/targets(13586)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(13586)/publications"},"_namespace":null},{"id":13587,"version":3,"created":1554966094000,"modified":1555041468000,"deprecated":false,"name":"Zinc finger protein 576","accession":"Q9H609","gene":"ZNF576","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":19,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":27.55888093391931,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13587)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/properties"},"_links":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(13587)/publications"},"_namespace":null},{"id":13588,"version":3,"created":1554966096000,"modified":1555041471000,"deprecated":false,"name":"La-related protein 4B","accession":"Q92615","gene":"LARP4B","description":"Stimulates mRNA translation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7140102545432284,"antibodyCount":24,"monoclonalCount":1,"pubmedCount":null,"jensenScore":5.115618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":69,"knowledgeAvailability":35.76022967470825,"pubTatorScore":0.5593080109070125,"self":"https://pharos.nih.gov/idg/api/v1/targets(13588)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(13588)/publications"},"_namespace":null},{"id":13589,"version":3,"created":1554966101000,"modified":1555041472000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit G","accession":"O75821","gene":"EIF3G","description":"(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0866576659656382,"antibodyCount":190,"monoclonalCount":9,"pubmedCount":null,"jensenScore":12.468238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":39.69820679497177,"pubTatorScore":0.951109964665797,"self":"https://pharos.nih.gov/idg/api/v1/targets(13589)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(13589)/publications"},"_namespace":null},{"id":13590,"version":2,"created":1554966106000,"modified":1554966109000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit J","accession":"O75822","gene":"EIF3J","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0212071988858826,"antibodyCount":106,"monoclonalCount":4,"pubmedCount":null,"jensenScore":10.319215,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.13407647402364,"pubTatorScore":1.3786141766189737,"self":"https://pharos.nih.gov/idg/api/v1/targets(13590)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(13590)/publications"},"_namespace":null},{"id":13591,"version":2,"created":1554966110000,"modified":1554966113000,"deprecated":false,"name":"Zinc finger protein 189","accession":"O75820","gene":"ZNF189","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.4771212590626073,"antibodyCount":43,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.904761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.89445489363687,"pubTatorScore":0.691670706707128,"self":"https://pharos.nih.gov/idg/api/v1/targets(13591)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13591)/publications"},"_namespace":null},{"id":13592,"version":2,"created":1554966114000,"modified":1554966118000,"deprecated":false,"name":"Rho GTPase-activating protein 45","accession":"Q92619","gene":"ARHGAP45","description":"Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. 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Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9892139396180415,"antibodyCount":85,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.382588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.20463193811738,"pubTatorScore":0.5808705999704371,"self":"https://pharos.nih.gov/idg/api/v1/targets(13593)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(13593)/publications"},"_namespace":null},{"id":13594,"version":2,"created":1554966123000,"modified":1554966127000,"deprecated":false,"name":"Membrane-associated progesterone receptor component 1","accession":"O00264","gene":"PGRMC1","description":"Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1287423926384497,"antibodyCount":133,"monoclonalCount":9,"pubmedCount":null,"jensenScore":1353.673283,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.14774107421195,"pubTatorScore":2.1001640786377482,"self":"https://pharos.nih.gov/idg/api/v1/targets(13594)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(13594)/publications"},"_namespace":null},{"id":13595,"version":2,"created":1554966129000,"modified":1554966133000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 4","accession":"O00268","gene":"TAF4","description":"Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. 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Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266). May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865). May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.176207665576002,"antibodyCount":60,"monoclonalCount":15,"pubmedCount":null,"jensenScore":148.917557,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.95518346490242,"pubTatorScore":1.1419720550275374,"self":"https://pharos.nih.gov/idg/api/v1/targets(13596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(13596)/publications"},"_namespace":null},{"id":13597,"version":2,"created":1554966138000,"modified":1554966142000,"deprecated":false,"name":"Transcription elongation factor SPT5","accession":"O00267","gene":"SUPT5H","description":"Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. 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Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. 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May play a role in the cellular response to oxidative stress (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8784944542235943,"antibodyCount":52,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.652381,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.44865554743532,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(13693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(13693)/publications"},"_namespace":null},{"id":13694,"version":2,"created":1554966756000,"modified":1554966760000,"deprecated":false,"name":"IQ motif and SEC7 domain-containing protein 2","accession":"Q5JU85","gene":"IQSEC2","description":"Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4244414304798556,"antibodyCount":50,"monoclonalCount":2,"pubmedCount":null,"jensenScore":29.77378,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.76474842785711,"pubTatorScore":1.2385905878628563,"self":"https://pharos.nih.gov/idg/api/v1/targets(13694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(13694)/publications"},"_namespace":null},{"id":13695,"version":2,"created":1554966761000,"modified":1554966765000,"deprecated":false,"name":"Copper transport protein ATOX1","accession":"O00244","gene":"ATOX1","description":"Binds and deliver cytosolic copper to the copper ATPase proteins. 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May play a role in cilium biogenesis (PubMed:27588451).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4648868019217715,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.865705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.40799279412868,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(13697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(13697)/publications"},"_namespace":null},{"id":13698,"version":2,"created":1554966774000,"modified":1554966778000,"deprecated":false,"name":"Lysophospholipase-like protein 1","accession":"Q5VWZ2","gene":"LYPLAL1","description":"Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1862303244562467,"antibodyCount":127,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.351079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.003641885843464,"pubTatorScore":1.1019388221005013,"self":"https://pharos.nih.gov/idg/api/v1/targets(13698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(13698)/publications"},"_namespace":null},{"id":13699,"version":3,"created":1554966779000,"modified":1555041527000,"deprecated":false,"name":"Dual specificity tyrosine-phosphorylation-regulated kinase 2","accession":"Q92630","gene":"DYRK2","description":"Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.5860176391489063,"antibodyCount":247,"monoclonalCount":44,"pubmedCount":null,"jensenScore":36.489192,"patentCount":3632,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.26853654320587,"pubTatorScore":1.4458328403742196,"self":"https://pharos.nih.gov/idg/api/v1/targets(13699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(13699)/publications"},"_namespace":null},{"id":13700,"version":3,"created":1554966784000,"modified":1555041529000,"deprecated":false,"name":"Protein FAN","accession":"Q92636","gene":"NSMAF","description":"Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9938575099681232,"antibodyCount":96,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.296653,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":41.03652404097106,"pubTatorScore":1.6980141916368547,"self":"https://pharos.nih.gov/idg/api/v1/targets(13700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/properties"},"_links":{"count":898,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(13700)/publications"},"_namespace":null},{"id":13701,"version":3,"created":1554966789000,"modified":1555041533000,"deprecated":false,"name":"Lysophosphatidic acid receptor 1","accession":"Q92633","gene":"LPAR1","description":"Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.3490546200672964,"antibodyCount":237,"monoclonalCount":20,"pubmedCount":null,"jensenScore":222.69017,"patentCount":23418,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":96,"knowledgeAvailability":39.71139627157746,"pubTatorScore":2.185615525442873,"self":"https://pharos.nih.gov/idg/api/v1/targets(13701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13701)/publications"},"_namespace":null},{"id":13702,"version":3,"created":1554966803000,"modified":1555041534000,"deprecated":false,"name":"Delta-sarcoglycan","accession":"Q92629","gene":"SGCD","description":"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1719216998759596,"antibodyCount":178,"monoclonalCount":38,"pubmedCount":null,"jensenScore":140.760579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.3395771198736,"pubTatorScore":1.6326058987284278,"self":"https://pharos.nih.gov/idg/api/v1/targets(13702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(13702)/publications"},"_namespace":null},{"id":13703,"version":2,"created":1554966808000,"modified":1554966812000,"deprecated":false,"name":"Uncharacterized protein KIAA0232","accession":"Q92628","gene":"KIAA0232","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.4,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.00790886397356,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(13703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13703)/publications"},"_namespace":null},{"id":13704,"version":2,"created":1554966812000,"modified":1554966817000,"deprecated":false,"name":"Protein CLEC16A","accession":"Q2KHT3","gene":"CLEC16A","description":"Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. 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Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6286158647681683,"antibodyCount":141,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.30746,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.14551117058072,"pubTatorScore":1.6706076978780262,"self":"https://pharos.nih.gov/idg/api/v1/targets(13704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(13704)/publications"},"_namespace":null},{"id":13705,"version":3,"created":1554966818000,"modified":1555041536000,"deprecated":false,"name":"Germ cell-specific gene 1 protein","accession":"Q2KHT4","gene":"GSG1","description":"May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":100,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":24.343499091034793,"pubTatorScore":-0.39280026683270164,"self":"https://pharos.nih.gov/idg/api/v1/targets(13705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/properties"},"_links":{"count":744,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13705)/publications"},"_namespace":null},{"id":13706,"version":2,"created":1554966821000,"modified":1554966826000,"deprecated":false,"name":"Peroxidasin homolog","accession":"Q92626","gene":"PXDN","description":"Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. 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Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.2653879042642236,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(13746)/publications"},"_namespace":null},{"id":13747,"version":3,"created":1554967024000,"modified":1555041554000,"deprecated":false,"name":"Toll-like receptor 4","accession":"O00206","gene":"TLR4","description":"Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.8192721522554933,"antibodyCount":1289,"monoclonalCount":673,"pubmedCount":null,"jensenScore":6905.756474,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.82334934560312,"pubTatorScore":3.5475047371253403,"self":"https://pharos.nih.gov/idg/api/v1/targets(13747)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2557,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/properties"},"_links":{"count":3058,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/links"},"_synonyms":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/synonyms"},"_publications":{"count":2046,"href":"https://pharos.nih.gov/idg/api/v1/targets(13747)/publications"},"_namespace":null},{"id":13748,"version":2,"created":1554967054000,"modified":1554967055000,"deprecated":false,"name":"PRAME family member 18","accession":"Q5VWM3","gene":"PRAMEF18","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13748)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/properties"},"_links":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(13748)/publications"},"_namespace":null},{"id":13749,"version":2,"created":1554967055000,"modified":1554967058000,"deprecated":false,"name":"Claudin-23","accession":"Q96B33","gene":"CLDN23","description":"Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6870876953751025,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.814132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.397912815200986,"pubTatorScore":0.6808328991341088,"self":"https://pharos.nih.gov/idg/api/v1/targets(13749)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/properties"},"_links":{"count":722,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(13749)/publications"},"_namespace":null},{"id":13750,"version":3,"created":1554967059000,"modified":1555041565000,"deprecated":false,"name":"Proline-rich AKT1 substrate 1","accession":"Q96B36","gene":"AKT1S1","description":"Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.257553754859258,"antibodyCount":434,"monoclonalCount":115,"pubmedCount":null,"jensenScore":174.159663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":39.85171520978411,"pubTatorScore":1.738778933839564,"self":"https://pharos.nih.gov/idg/api/v1/targets(13750)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(13750)/publications"},"_namespace":null},{"id":13751,"version":2,"created":1554967063000,"modified":1554967064000,"deprecated":false,"name":"Putative PRAME family member 13","accession":"Q5VWM6","gene":"PRAMEF13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.090909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(13751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/properties"},"_links":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(13751)/publications"},"_namespace":null},{"id":13752,"version":2,"created":1554967064000,"modified":1554967064000,"deprecated":false,"name":"PRAME family member 9/15","accession":"Q5VWM5","gene":"PRAMEF15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.983034951053189,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(13752)/publications"},"_namespace":null},{"id":13753,"version":3,"created":1554967064000,"modified":1555041566000,"deprecated":false,"name":"Golgin subfamily A member 7","accession":"Q7Z5G4","gene":"GOLGA7","description":"May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3960055135273124,"antibodyCount":93,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.535173,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.47771980860935,"pubTatorScore":0.22862027368254095,"self":"https://pharos.nih.gov/idg/api/v1/targets(13753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13753)/publications"},"_namespace":null},{"id":13754,"version":2,"created":1554967068000,"modified":1554967068000,"deprecated":false,"name":"PRAME family member 8","accession":"Q5VWM4","gene":"PRAMEF8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.2913673288999785,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/properties"},"_links":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(13754)/publications"},"_namespace":null},{"id":13755,"version":2,"created":1554967068000,"modified":1554967071000,"deprecated":false,"name":"Sulfotransferase family cytosolic 2B member 1","accession":"O00204","gene":"SULT2B1","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.316073550430515,"antibodyCount":185,"monoclonalCount":25,"pubmedCount":null,"jensenScore":178.163797,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.38340316027375,"pubTatorScore":1.5054148171862225,"self":"https://pharos.nih.gov/idg/api/v1/targets(13755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(13755)/publications"},"_namespace":null},{"id":13756,"version":2,"created":1554967072000,"modified":1554967077000,"deprecated":false,"name":"AP-3 complex subunit beta-1","accession":"O00203","gene":"AP3B1","description":"Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2769919886474803,"antibodyCount":89,"monoclonalCount":23,"pubmedCount":null,"jensenScore":21.010365,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.45898360596348,"pubTatorScore":1.3663910143926175,"self":"https://pharos.nih.gov/idg/api/v1/targets(13756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(13756)/publications"},"_namespace":null},{"id":13757,"version":2,"created":1554967078000,"modified":1554967081000,"deprecated":false,"name":"5-oxoprolinase","accession":"O14841","gene":"OPLAH","description":"Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.746730939289634,"pubTatorScore":1.148934818547686,"self":"https://pharos.nih.gov/idg/api/v1/targets(13757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/properties"},"_links":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(13757)/publications"},"_namespace":null},{"id":13758,"version":2,"created":1554967081000,"modified":1554967084000,"deprecated":false,"name":"Free fatty acid receptor 3","accession":"O14843","gene":"FFAR3","description":"G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.7539546612120667,"antibodyCount":120,"monoclonalCount":3,"pubmedCount":null,"jensenScore":54.954687,"patentCount":4253,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.59721781107618,"pubTatorScore":1.5391811326373617,"self":"https://pharos.nih.gov/idg/api/v1/targets(13758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(13758)/publications"},"_namespace":null},{"id":13759,"version":3,"created":1554967084000,"modified":1554967167000,"deprecated":false,"name":"Free fatty acid receptor 1","accession":"O14842","gene":"FFAR1","description":"G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.438014224846319,"antibodyCount":231,"monoclonalCount":7,"pubmedCount":null,"jensenScore":296.216516,"patentCount":29866,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.196074619717667,"pubTatorScore":2.1892318863521654,"self":"https://pharos.nih.gov/idg/api/v1/targets(13759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(13759)/publications"},"_namespace":null},{"id":13760,"version":3,"created":1554967168000,"modified":1555041568000,"deprecated":false,"name":"Kelch-like protein 40","accession":"Q2TBA0","gene":"KLHL40","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1856702824169048,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.804843,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":16.84931712069857,"pubTatorScore":0.5186705208698187,"self":"https://pharos.nih.gov/idg/api/v1/targets(13760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/properties"},"_links":{"count":706,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13760)/publications"},"_namespace":null},{"id":13761,"version":2,"created":1554967171000,"modified":1554967174000,"deprecated":false,"name":"Uncharacterized protein C18orf25","accession":"Q96B23","gene":"C18orf25","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.23044892441833534,"antibodyCount":90,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.49359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3635222916413859,"self":"https://pharos.nih.gov/idg/api/v1/targets(13761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(13761)/publications"},"_namespace":null},{"id":13762,"version":2,"created":1554967175000,"modified":1554967178000,"deprecated":false,"name":"Protein LSM12 homolog","accession":"Q3MHD2","gene":"LSM12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7819442428294234,"antibodyCount":74,"monoclonalCount":7,"pubmedCount":null,"jensenScore":5.885318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.17083156130934,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(13762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13762)/publications"},"_namespace":null},{"id":13763,"version":2,"created":1554967179000,"modified":1554967187000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","accession":"O00217","gene":"NDUFS8","description":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. 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May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.817487200114034,"antibodyCount":215,"monoclonalCount":19,"pubmedCount":null,"jensenScore":78.50787,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.88460969292632,"pubTatorScore":1.6685745235601872,"self":"https://pharos.nih.gov/idg/api/v1/targets(13769)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(13769)/publications"},"_namespace":null},{"id":13770,"version":3,"created":1554967212000,"modified":1555041573000,"deprecated":false,"name":"Amyloid-beta A4 precursor protein-binding family B member 1","accession":"O00213","gene":"APBB1","description":"Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.289036881004724,"antibodyCount":285,"monoclonalCount":21,"pubmedCount":null,"jensenScore":200.761293,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":36.58553857152854,"pubTatorScore":2.0138727512978662,"self":"https://pharos.nih.gov/idg/api/v1/targets(13770)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/properties"},"_links":{"count":1298,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/links"},"_synonyms":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(13770)/publications"},"_namespace":null},{"id":13771,"version":3,"created":1554967218000,"modified":1555041576000,"deprecated":false,"name":"Pre-B-cell leukemia transcription factor-interacting protein 1","accession":"Q96AQ6","gene":"PBXIP1","description":"Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8017139810006922,"antibodyCount":110,"monoclonalCount":7,"pubmedCount":null,"jensenScore":8.755112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":65,"knowledgeAvailability":37.971357096207534,"pubTatorScore":1.40214595658361,"self":"https://pharos.nih.gov/idg/api/v1/targets(13771)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(13771)/publications"},"_namespace":null},{"id":13772,"version":3,"created":1554967223000,"modified":1555041578000,"deprecated":false,"name":"Exosome complex component RRP43","accession":"Q96B26","gene":"EXOSC8","description":"Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4405645348788028,"antibodyCount":87,"monoclonalCount":23,"pubmedCount":null,"jensenScore":25.607471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":34.55040704459835,"pubTatorScore":1.547662820163121,"self":"https://pharos.nih.gov/idg/api/v1/targets(13772)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(13772)/publications"},"_namespace":null},{"id":13773,"version":3,"created":1554967228000,"modified":1555041581000,"deprecated":false,"name":"Rho-related GTP-binding protein RhoD","accession":"O00212","gene":"RHOD","description":"Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1925062386321597,"antibodyCount":118,"monoclonalCount":19,"pubmedCount":null,"jensenScore":159.213048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":33.82611030139532,"pubTatorScore":1.4564477365832693,"self":"https://pharos.nih.gov/idg/api/v1/targets(13773)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/properties"},"_links":{"count":853,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(13773)/publications"},"_namespace":null},{"id":13774,"version":2,"created":1554967232000,"modified":1554967234000,"deprecated":false,"name":"Protein FAM131C","accession":"Q96AQ9","gene":"FAM131C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":35,"monoclonalCount":14,"pubmedCount":null,"jensenScore":0.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.807435328614307,"pubTatorScore":-1.1461254299191639,"self":"https://pharos.nih.gov/idg/api/v1/targets(13774)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/properties"},"_links":{"count":687,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(13774)/publications"},"_namespace":null},{"id":13775,"version":3,"created":1554967234000,"modified":1555041582000,"deprecated":false,"name":"Mitochondrial calcium uniporter regulator 1","accession":"Q96AQ8","gene":"MCUR1","description":"Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). 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Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7243113303243157,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.386462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.98065173076965,"pubTatorScore":0.7429868071580736,"self":"https://pharos.nih.gov/idg/api/v1/targets(13775)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(13775)/publications"},"_namespace":null},{"id":13776,"version":3,"created":1554967238000,"modified":1555041588000,"deprecated":false,"name":"Galectin-8","accession":"O00214","gene":"LGALS8","description":"Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). 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Required in the control of cell shape and migration.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8096035827649,"antibodyCount":152,"monoclonalCount":37,"pubmedCount":null,"jensenScore":71.139153,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":42.857562718470696,"pubTatorScore":1.8347545179289002,"self":"https://pharos.nih.gov/idg/api/v1/targets(13784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13784)/publications"},"_namespace":null},{"id":13785,"version":2,"created":1554967273000,"modified":1554967273000,"deprecated":false,"name":"Protein FAM240B","accession":"A0A1B0GVZ2","gene":"FAM240B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/properties"},"_links":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(13785)/publications"},"_namespace":null},{"id":13786,"version":2,"created":1554967273000,"modified":1554967277000,"deprecated":false,"name":"Ras-related protein Rab-37","accession":"Q96AX2","gene":"RAB37","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9955261339304201,"antibodyCount":241,"monoclonalCount":123,"pubmedCount":null,"jensenScore":10.255168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.17604080599497,"pubTatorScore":0.9502341081631738,"self":"https://pharos.nih.gov/idg/api/v1/targets(13786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(13786)/publications"},"_namespace":null},{"id":13787,"version":2,"created":1554967278000,"modified":1554967282000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 33A","accession":"Q96AX1","gene":"VPS33A","description":"Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9426560095064573,"antibodyCount":45,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.41823,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.44502637538357,"pubTatorScore":0.6367460894019311,"self":"https://pharos.nih.gov/idg/api/v1/targets(13787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13787)/publications"},"_namespace":null},{"id":13788,"version":3,"created":1554967282000,"modified":1555041595000,"deprecated":false,"name":"TATA box-binding protein-associated factor RNA polymerase I subunit D","accession":"Q9H5J8","gene":"TAF1D","description":"Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. 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Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.2710667688121821,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.88952,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.773578939192102,"pubTatorScore":-0.2041199826559248,"self":"https://pharos.nih.gov/idg/api/v1/targets(13788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(13788)/publications"},"_namespace":null},{"id":13789,"version":3,"created":1554967286000,"modified":1555041598000,"deprecated":false,"name":"Spermatogenesis-associated protein 19, mitochondrial","accession":"Q7Z5L4","gene":"SPATA19","description":"May have a role in spermiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0256958786975765,"antibodyCount":82,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.686975,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":15.160518111625569,"pubTatorScore":1.0528038287600496,"self":"https://pharos.nih.gov/idg/api/v1/targets(13789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/properties"},"_links":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13789)/publications"},"_namespace":null},{"id":13790,"version":2,"created":1554967289000,"modified":1554967290000,"deprecated":false,"name":"Complement C1q-like protein 2","accession":"Q7Z5L3","gene":"C1QL2","description":"May regulate the number of excitatory synapses that are formed on hippocampus neurons. 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Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5209384600957747,"antibodyCount":139,"monoclonalCount":3,"pubmedCount":null,"jensenScore":31.55451,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.24264246281398,"pubTatorScore":1.325773331244391,"self":"https://pharos.nih.gov/idg/api/v1/targets(13806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(13806)/publications"},"_namespace":null},{"id":13807,"version":3,"created":1554967383000,"modified":1555041605000,"deprecated":false,"name":"Transmembrane protein 186","accession":"Q96B77","gene":"TMEM186","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":25.638709279815917,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(13807)/publications"},"_namespace":null},{"id":13808,"version":2,"created":1554967386000,"modified":1554967390000,"deprecated":false,"name":"Fibronectin type III domain-containing protein 1","accession":"Q4ZHG4","gene":"FNDC1","description":"May be an activator of G protein signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8614063746188663,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.421777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.074324344955535,"pubTatorScore":0.7169882415191436,"self":"https://pharos.nih.gov/idg/api/v1/targets(13808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13808)/publications"},"_namespace":null},{"id":13809,"version":3,"created":1554967391000,"modified":1555041606000,"deprecated":false,"name":"Wings apart-like protein homolog","accession":"Q7Z5K2","gene":"WAPL","description":"Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3902050293220225,"antibodyCount":125,"monoclonalCount":26,"pubmedCount":null,"jensenScore":215.188029,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.8652358249148278,"self":"https://pharos.nih.gov/idg/api/v1/targets(13809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/properties"},"_links":{"count":1065,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(13809)/publications"},"_namespace":null},{"id":13810,"version":3,"created":1554967396000,"modified":1555041607000,"deprecated":false,"name":"Disabled homolog 2-interacting protein","accession":"Q5VWQ8","gene":"DAB2IP","description":"Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.691928208412532,"antibodyCount":59,"monoclonalCount":6,"pubmedCount":null,"jensenScore":60.308144,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":42.75660279308065,"pubTatorScore":1.7117573286900758,"self":"https://pharos.nih.gov/idg/api/v1/targets(13810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(13810)/publications"},"_namespace":null},{"id":13811,"version":2,"created":1554967401000,"modified":1554967403000,"deprecated":false,"name":"T-complex-associated testis-expressed protein 1","accession":"Q5JU00","gene":"TCTE1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8513311573430256,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.32851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.10444104065499,"pubTatorScore":0.7029157444880845,"self":"https://pharos.nih.gov/idg/api/v1/targets(13811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(13811)/publications"},"_namespace":null},{"id":13812,"version":3,"created":1554967404000,"modified":1555041609000,"deprecated":false,"name":"Lysine-specific demethylase 9","accession":"Q5VWQ0","gene":"RSBN1","description":"Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4122532155800742,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.497442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":34.805642045870435,"pubTatorScore":0.38958776564918773,"self":"https://pharos.nih.gov/idg/api/v1/targets(13812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(13812)/publications"},"_namespace":null},{"id":13813,"version":2,"created":1554967410000,"modified":1554967414000,"deprecated":false,"name":"DNA-directed RNA polymerase III subunit RPC1","accession":"O14802","gene":"POLR3A","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2563178059934956,"antibodyCount":99,"monoclonalCount":1,"pubmedCount":null,"jensenScore":178.201892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.8882399157901,"pubTatorScore":1.6819443787336046,"self":"https://pharos.nih.gov/idg/api/v1/targets(13813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(13813)/publications"},"_namespace":null},{"id":13814,"version":2,"created":1554967415000,"modified":1554967417000,"deprecated":false,"name":"Trace amine-associated receptor 5","accession":"O14804","gene":"TAAR5","description":"Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.150483541136812,"antibodyCount":129,"monoclonalCount":2,"pubmedCount":null,"jensenScore":143.636975,"patentCount":10169,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.899880442196169,"pubTatorScore":1.6172318611617527,"self":"https://pharos.nih.gov/idg/api/v1/targets(13814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/properties"},"_links":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13814)/publications"},"_namespace":null},{"id":13815,"version":3,"created":1554967417000,"modified":1555041610000,"deprecated":false,"name":"Ras-related protein M-Ras","accession":"O14807","gene":"MRAS","description":"May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4899539106709168,"antibodyCount":74,"monoclonalCount":12,"pubmedCount":null,"jensenScore":309.918464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.04974513673041,"pubTatorScore":1.352722560350065,"self":"https://pharos.nih.gov/idg/api/v1/targets(13815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(13815)/publications"},"_namespace":null},{"id":13816,"version":2,"created":1554967423000,"modified":1554967427000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 L3","accession":"P68036","gene":"UBE2L3","description":"Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7480052448703838,"antibodyCount":325,"monoclonalCount":30,"pubmedCount":null,"jensenScore":58.402047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.39284675288242,"pubTatorScore":1.8475703951294657,"self":"https://pharos.nih.gov/idg/api/v1/targets(13816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/properties"},"_links":{"count":1173,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(13816)/publications"},"_namespace":null},{"id":13817,"version":2,"created":1554967428000,"modified":1554967429000,"deprecated":false,"name":"Leukocyte receptor cluster member 9","accession":"Q96B70","gene":"LENG9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.877005219150313,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/properties"},"_links":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(13817)/publications"},"_namespace":null},{"id":13818,"version":2,"created":1554967430000,"modified":1554967432000,"deprecated":false,"name":"CWF19-like protein 2","accession":"Q2TBE0","gene":"CWF19L2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0,"antibodyCount":25,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.681231941811447,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(13818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(13818)/publications"},"_namespace":null},{"id":13819,"version":2,"created":1554967433000,"modified":1554967437000,"deprecated":false,"name":"Zinc finger protein 768","accession":"Q9H5H4","gene":"ZNF768","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0,"antibodyCount":105,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.041667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.26652336200845,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(13819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(13819)/publications"},"_namespace":null},{"id":13820,"version":3,"created":1554967437000,"modified":1555041612000,"deprecated":false,"name":"Transmembrane 4 L6 family member 20","accession":"Q53R12","gene":"TM4SF20","description":"Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":41,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.510684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":17.364744693144875,"pubTatorScore":0.31875869313729016,"self":"https://pharos.nih.gov/idg/api/v1/targets(13820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/properties"},"_links":{"count":616,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(13820)/publications"},"_namespace":null},{"id":13821,"version":2,"created":1554967440000,"modified":1554967441000,"deprecated":false,"name":"Prickle-like protein 4","accession":"Q2TBC4","gene":"PRICKLE4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3454491363571743,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.804733,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.508821796176903,"pubTatorScore":0.17849723284486796,"self":"https://pharos.nih.gov/idg/api/v1/targets(13821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/properties"},"_links":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(13821)/publications"},"_namespace":null},{"id":13822,"version":3,"created":1554967441000,"modified":1555041614000,"deprecated":false,"name":"Arrestin domain-containing protein 3","accession":"Q96B67","gene":"ARRDC3","description":"Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). 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Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. 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May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0468073383699923,"antibodyCount":157,"monoclonalCount":8,"pubmedCount":null,"jensenScore":115.675415,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.55751815674542,"pubTatorScore":1.8087112242882877,"self":"https://pharos.nih.gov/idg/api/v1/targets(13830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(13830)/publications"},"_namespace":null},{"id":13831,"version":2,"created":1554967484000,"modified":1554967494000,"deprecated":false,"name":"Protein ALEX","accession":"P84996","gene":"GNAS","description":"May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6335564959942657,"antibodyCount":509,"monoclonalCount":63,"pubmedCount":null,"jensenScore":1389.742966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.128609119577192,"self":"https://pharos.nih.gov/idg/api/v1/targets(13831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/properties"},"_links":{"count":1657,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/synonyms"},"_publications":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(13831)/publications"},"_namespace":null},{"id":13832,"version":3,"created":1554967497000,"modified":1555041615000,"deprecated":false,"name":"Complexin-1","accession":"O14810","gene":"CPLX1","description":"Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.927299493699394,"antibodyCount":106,"monoclonalCount":3,"pubmedCount":null,"jensenScore":82.007106,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.12017829903576,"pubTatorScore":1.4188764333865074,"self":"https://pharos.nih.gov/idg/api/v1/targets(13832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(13832)/publications"},"_namespace":null},{"id":13833,"version":3,"created":1554967502000,"modified":1555041616000,"deprecated":false,"name":"Fibulin-7","accession":"Q53RD9","gene":"FBLN7","description":"An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2401330297413644,"antibodyCount":105,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.718226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":20.921314014305047,"pubTatorScore":0.8672709796627784,"self":"https://pharos.nih.gov/idg/api/v1/targets(13833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(13833)/publications"},"_namespace":null},{"id":13834,"version":3,"created":1554967506000,"modified":1555041617000,"deprecated":false,"name":"Protein FAM149B1","accession":"Q96BN6","gene":"FAM149B1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":25,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.442179985526945,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(13834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/properties"},"_links":{"count":822,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(13834)/publications"},"_namespace":null},{"id":13835,"version":3,"created":1554967509000,"modified":1555041618000,"deprecated":false,"name":"Ubiquitin thioesterase otulin","accession":"Q96BN8","gene":"OTULIN","description":"Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327). 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