{"id":327300,"version":1,"created":1584652476003,"modified":1584652476008,"deprecated":false,"etag":"776e2799b0310ed2","uri":"https://pharos.nih.gov/idg/api/v1/targets?top=1000&skip=12000","path":"/idg/api/v1/targets","method":"GET","sha1":"97018d676813cb41bf1f03d84edfcc589327cc0f","total":20244,"count":1000,"skip":12000,"top":1000,"status":null,"query":"skip=12000&top=1000","filter":null,"_namespace":null,"content":[{"id":12001,"version":2,"created":1554948902000,"modified":1554948905000,"deprecated":false,"name":"CKLF-like MARVEL transmembrane domain-containing protein 5","accession":"Q96DZ9","gene":"CMTM5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9766337742307392,"antibodyCount":166,"monoclonalCount":27,"pubmedCount":null,"jensenScore":13.238795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.081579157672337,"pubTatorScore":1.1707504910457605,"self":"https://pharos.nih.gov/idg/api/v1/targets(12001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(12001)/properties"},"_links":{"count":756,"href":"https://pharos.nih.gov/idg/api/v1/targets(12001)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12001)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12001)/publications"},"_namespace":null},{"id":12002,"version":2,"created":1554948906000,"modified":1554948922000,"deprecated":false,"name":"Bromodomain-containing protein 9","accession":"Q9H8M2","gene":"BRD9","description":"Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.4047027835439432,"antibodyCount":109,"monoclonalCount":1,"pubmedCount":null,"jensenScore":24.746136,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.76530309024261,"pubTatorScore":0.7686365475507774,"self":"https://pharos.nih.gov/idg/api/v1/targets(12002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(12002)/properties"},"_links":{"count":981,"href":"https://pharos.nih.gov/idg/api/v1/targets(12002)/links"},"_synonyms":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(12002)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12002)/publications"},"_namespace":null},{"id":12003,"version":3,"created":1554948924000,"modified":1555040383000,"deprecated":false,"name":"Voltage-dependent L-type calcium channel subunit beta-4","accession":"O00305","gene":"CACNB4","description":"The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.563365612289933,"antibodyCount":234,"monoclonalCount":70,"pubmedCount":null,"jensenScore":35.593674,"patentCount":5640,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":42.85330044043211,"pubTatorScore":1.2536426558754117,"self":"https://pharos.nih.gov/idg/api/v1/targets(12003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(12003)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(12003)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(12003)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12003)/publications"},"_namespace":null},{"id":12004,"version":2,"created":1554948928000,"modified":1554948930000,"deprecated":false,"name":"Molybdopterin synthase catalytic subunit","accession":"O96007","gene":"MOCS2","description":"Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0548328666571187,"antibodyCount":92,"monoclonalCount":6,"pubmedCount":null,"jensenScore":207.619923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.854272140512585,"pubTatorScore":1.4637863573473329,"self":"https://pharos.nih.gov/idg/api/v1/targets(12004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(12004)/properties"},"_links":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(12004)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12004)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12004)/publications"},"_namespace":null},{"id":12005,"version":3,"created":1554948930000,"modified":1555040384000,"deprecated":false,"name":"Septin-2","accession":"Q15019","gene":"SEPT2","description":"Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2934657010413577,"antibodyCount":321,"monoclonalCount":26,"pubmedCount":null,"jensenScore":191.951961,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":42.74291818328906,"pubTatorScore":1.7456862006926375,"self":"https://pharos.nih.gov/idg/api/v1/targets(12005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":501,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/properties"},"_links":{"count":1346,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12005)/publications"},"_namespace":null},{"id":12006,"version":2,"created":1554948937000,"modified":1554948940000,"deprecated":false,"name":"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial","accession":"Q9H8M1","gene":"COQ10B","description":"Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.090909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.6141363037212,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(12006)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(12006)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12006)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12006)/publications"},"_namespace":null},{"id":12007,"version":3,"created":1554948940000,"modified":1555040386000,"deprecated":false,"name":"BRISC complex subunit Abraxas 2","accession":"Q15018","gene":"ABRAXAS2","description":"Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3464771634251521,"antibodyCount":70,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.474886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":0.0,"pubTatorScore":0.5032067840837243,"self":"https://pharos.nih.gov/idg/api/v1/targets(12007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12007)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(12007)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12007)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12007)/publications"},"_namespace":null},{"id":12008,"version":3,"created":1554948944000,"modified":1555040387000,"deprecated":false,"name":"Zinc finger BED domain-containing protein 1","accession":"O96006","gene":"ZBED1","description":"Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.0953726205822294,"antibodyCount":302,"monoclonalCount":158,"pubmedCount":null,"jensenScore":120.882739,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":23.494300404057604,"pubTatorScore":1.4655952617106567,"self":"https://pharos.nih.gov/idg/api/v1/targets(12008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(12008)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(12008)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12008)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12008)/publications"},"_namespace":null},{"id":12009,"version":2,"created":1554948948000,"modified":1554948949000,"deprecated":false,"name":"Putative aldo-keto reductase family 1 member C8","accession":"Q5T2L2","gene":"AKR1C8P","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.22184875048494532,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.446429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.800814300708924,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12009)/properties"},"_links":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(12009)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12009)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12009)/publications"},"_namespace":null},{"id":12010,"version":2,"created":1554948949000,"modified":1554948952000,"deprecated":false,"name":"Cleft lip and palate transmembrane protein 1","accession":"O96005","gene":"CLPTM1","description":"May play a role in T-cell development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9771122950362776,"antibodyCount":121,"monoclonalCount":4,"pubmedCount":null,"jensenScore":5.940069,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.53951756195427,"pubTatorScore":0.7210670635484392,"self":"https://pharos.nih.gov/idg/api/v1/targets(12010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(12010)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(12010)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12010)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12010)/publications"},"_namespace":null},{"id":12011,"version":2,"created":1554948953000,"modified":1554948955000,"deprecated":false,"name":"Heart- and neural crest derivatives-expressed protein 1","accession":"O96004","gene":"HAND1","description":"Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1772181940630837,"antibodyCount":234,"monoclonalCount":39,"pubmedCount":null,"jensenScore":147.534698,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.364596755359496,"pubTatorScore":1.9184580215848073,"self":"https://pharos.nih.gov/idg/api/v1/targets(12011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(12011)/properties"},"_links":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(12011)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12011)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12011)/publications"},"_namespace":null},{"id":12012,"version":2,"created":1554948956000,"modified":1554948958000,"deprecated":false,"name":"Zinc finger protein 671","accession":"Q8TAW3","gene":"ZNF671","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.2736657893153851,"antibodyCount":66,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.339812,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.259655749186287,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12012)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(12012)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12012)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12012)/publications"},"_namespace":null},{"id":12013,"version":3,"created":1554948959000,"modified":1555040389000,"deprecated":false,"name":"CAP-Gly domain-containing linker protein 3","accession":"Q96DZ5","gene":"CLIP3","description":"Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.012133925158402,"antibodyCount":101,"monoclonalCount":20,"pubmedCount":null,"jensenScore":12.446944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.30301613741449,"pubTatorScore":0.950666126855099,"self":"https://pharos.nih.gov/idg/api/v1/targets(12013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(12013)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(12013)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12013)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12013)/publications"},"_namespace":null},{"id":12014,"version":3,"created":1554948964000,"modified":1555040390000,"deprecated":false,"name":"NEDD4-like E3 ubiquitin-protein ligase WWP2","accession":"O00308","gene":"WWP2","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6057837425618837,"antibodyCount":124,"monoclonalCount":5,"pubmedCount":null,"jensenScore":42.98899,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":44.74816371534487,"pubTatorScore":1.4467516207973201,"self":"https://pharos.nih.gov/idg/api/v1/targets(12014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(12014)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(12014)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12014)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(12014)/publications"},"_namespace":null},{"id":12015,"version":2,"created":1554948968000,"modified":1554948973000,"deprecated":false,"name":"Solute carrier family 15 member 2","accession":"Q16348","gene":"SLC15A2","description":"Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.1532430254301924,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":150.143504,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.25130491196087,"pubTatorScore":1.9118022412304305,"self":"https://pharos.nih.gov/idg/api/v1/targets(12015)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(12015)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(12015)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12015)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12015)/publications"},"_namespace":null},{"id":12016,"version":3,"created":1554948973000,"modified":1555040391000,"deprecated":false,"name":"Napsin-A","accession":"O96009","gene":"NAPSA","description":"May be involved in processing of pneumocyte surfactant precursors.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.008269903503382,"antibodyCount":427,"monoclonalCount":209,"pubmedCount":null,"jensenScore":104.620231,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":26.48534879256501,"pubTatorScore":1.9187353511459384,"self":"https://pharos.nih.gov/idg/api/v1/targets(12016)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(12016)/properties"},"_links":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(12016)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12016)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12016)/publications"},"_namespace":null},{"id":12017,"version":2,"created":1554948978000,"modified":1554948980000,"deprecated":false,"name":"Transmembrane 4 L6 family member 19","accession":"Q96DZ7","gene":"TM4SF19","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.3669719446667,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12017)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(12017)/properties"},"_links":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(12017)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12017)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12017)/publications"},"_namespace":null},{"id":12018,"version":3,"created":1554948980000,"modified":1555040393000,"deprecated":false,"name":"Integrin alpha-1","accession":"P56199","gene":"ITGA1","description":"Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9787920887082395,"antibodyCount":397,"monoclonalCount":196,"pubmedCount":null,"jensenScore":88.916267,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.805239606876306,"pubTatorScore":2.100826452812809,"self":"https://pharos.nih.gov/idg/api/v1/targets(12018)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":494,"href":"https://pharos.nih.gov/idg/api/v1/targets(12018)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(12018)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(12018)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12018)/publications"},"_namespace":null},{"id":12019,"version":2,"created":1554948986000,"modified":1554948990000,"deprecated":false,"name":"Mitochondrial import receptor subunit TOM40 homolog","accession":"O96008","gene":"TOMM40","description":"Channel-forming protein essential for import of protein precursors into mitochondria.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2197280642806483,"antibodyCount":94,"monoclonalCount":0,"pubmedCount":null,"jensenScore":158.938331,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.70460177243687,"pubTatorScore":2.1292989156641404,"self":"https://pharos.nih.gov/idg/api/v1/targets(12019)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":545,"href":"https://pharos.nih.gov/idg/api/v1/targets(12019)/properties"},"_links":{"count":1400,"href":"https://pharos.nih.gov/idg/api/v1/targets(12019)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12019)/synonyms"},"_publications":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12019)/publications"},"_namespace":null},{"id":12020,"version":2,"created":1554948991000,"modified":1554948991000,"deprecated":false,"name":"Putative transmembrane protein CXorf1","accession":"O96002","gene":"CXorf1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.15490196042003768,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.957143,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12020)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12020)/properties"},"_links":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(12020)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12020)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12020)/publications"},"_namespace":null},{"id":12021,"version":2,"created":1554948991000,"modified":1554949001000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 11B","accession":"O00300","gene":"TNFRSF11B","description":"Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.313310117444397,"antibodyCount":536,"monoclonalCount":159,"pubmedCount":null,"jensenScore":1623.992316,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.358695442598695,"pubTatorScore":3.223761793168892,"self":"https://pharos.nih.gov/idg/api/v1/targets(12021)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(12021)/properties"},"_links":{"count":1534,"href":"https://pharos.nih.gov/idg/api/v1/targets(12021)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12021)/synonyms"},"_publications":{"count":614,"href":"https://pharos.nih.gov/idg/api/v1/targets(12021)/publications"},"_namespace":null},{"id":12022,"version":3,"created":1554949004000,"modified":1555040395000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit F","accession":"O00303","gene":"EIF3F","description":"Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3873480405339635,"antibodyCount":167,"monoclonalCount":2,"pubmedCount":null,"jensenScore":25.258022,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":41.88910561211674,"pubTatorScore":1.3220099764008928,"self":"https://pharos.nih.gov/idg/api/v1/targets(12022)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(12022)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(12022)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12022)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12022)/publications"},"_namespace":null},{"id":12023,"version":2,"created":1554949008000,"modified":1554949010000,"deprecated":false,"name":"Protein phosphatase 1 regulatory subunit 17","accession":"O96001","gene":"PPP1R17","description":"Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.282347800982311,"antibodyCount":70,"monoclonalCount":26,"pubmedCount":null,"jensenScore":185.98842,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.76804434508479,"pubTatorScore":1.2974826050061783,"self":"https://pharos.nih.gov/idg/api/v1/targets(12023)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(12023)/properties"},"_links":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(12023)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12023)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12023)/publications"},"_namespace":null},{"id":12024,"version":2,"created":1554949011000,"modified":1554949017000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10","accession":"O96000","gene":"NDUFB10","description":"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.7256686755017083,"antibodyCount":208,"monoclonalCount":97,"pubmedCount":null,"jensenScore":4.507937,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.363038379250625,"pubTatorScore":0.30232053666817765,"self":"https://pharos.nih.gov/idg/api/v1/targets(12024)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(12024)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(12024)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12024)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12024)/publications"},"_namespace":null},{"id":12025,"version":2,"created":1554949018000,"modified":1554949022000,"deprecated":false,"name":"Transcription factor EC","accession":"O14948","gene":"TFEC","description":"Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4967794472454665,"antibodyCount":172,"monoclonalCount":11,"pubmedCount":null,"jensenScore":33.164881,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.8863471134569,"pubTatorScore":1.0582065439974464,"self":"https://pharos.nih.gov/idg/api/v1/targets(12025)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(12025)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(12025)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12025)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12025)/publications"},"_namespace":null},{"id":12026,"version":3,"created":1554949023000,"modified":1555040397000,"deprecated":false,"name":"Cytochrome b-c1 complex subunit 8","accession":"O14949","gene":"UQCRQ","description":"This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0392708156537647,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.973975,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":39.14056010399298,"pubTatorScore":0.7994171301885097,"self":"https://pharos.nih.gov/idg/api/v1/targets(12026)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(12026)/properties"},"_links":{"count":1141,"href":"https://pharos.nih.gov/idg/api/v1/targets(12026)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12026)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12026)/publications"},"_namespace":null},{"id":12027,"version":3,"created":1554949027000,"modified":1555040398000,"deprecated":false,"name":"Polycomb protein SUZ12","accession":"Q15022","gene":"SUZ12","description":"Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.140223644628795,"antibodyCount":232,"monoclonalCount":78,"pubmedCount":null,"jensenScore":107.65226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":45.28905308690587,"pubTatorScore":1.9841789595060655,"self":"https://pharos.nih.gov/idg/api/v1/targets(12027)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(12027)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12027)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12027)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12027)/publications"},"_namespace":null},{"id":12028,"version":3,"created":1554949034000,"modified":1555040400000,"deprecated":false,"name":"Endoplasmic reticulum lectin 1","accession":"Q96DZ1","gene":"ERLEC1","description":"Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6947088339611014,"antibodyCount":36,"monoclonalCount":1,"pubmedCount":null,"jensenScore":490.826461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":30.363776894696677,"pubTatorScore":1.4631164751195769,"self":"https://pharos.nih.gov/idg/api/v1/targets(12028)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(12028)/properties"},"_links":{"count":1143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12028)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12028)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12028)/publications"},"_namespace":null},{"id":12029,"version":2,"created":1554949038000,"modified":1554949042000,"deprecated":false,"name":"Condensin complex subunit 1","accession":"Q15021","gene":"NCAPD2","description":"Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1584462668944207,"antibodyCount":109,"monoclonalCount":20,"pubmedCount":null,"jensenScore":12.995165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.48519372439,"pubTatorScore":1.1692824518964324,"self":"https://pharos.nih.gov/idg/api/v1/targets(12029)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(12029)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12029)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12029)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12029)/publications"},"_namespace":null},{"id":12030,"version":2,"created":1554949043000,"modified":1554949046000,"deprecated":false,"name":"Regulator of G-protein signaling 7-binding protein","accession":"Q6MZT1","gene":"RGS7BP","description":"Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2461397551509599,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.367635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.142964877890957,"pubTatorScore":1.096289118916683,"self":"https://pharos.nih.gov/idg/api/v1/targets(12030)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(12030)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(12030)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12030)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12030)/publications"},"_namespace":null},{"id":12031,"version":3,"created":1554949047000,"modified":1555040403000,"deprecated":false,"name":"Squamous cell carcinoma antigen recognized by T-cells 3","accession":"Q15020","gene":"SART3","description":"Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.523840323647286,"antibodyCount":175,"monoclonalCount":6,"pubmedCount":null,"jensenScore":38.122586,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":58,"knowledgeAvailability":40.50196219323751,"pubTatorScore":2.0537255710511717,"self":"https://pharos.nih.gov/idg/api/v1/targets(12031)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(12031)/properties"},"_links":{"count":1157,"href":"https://pharos.nih.gov/idg/api/v1/targets(12031)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12031)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(12031)/publications"},"_namespace":null},{"id":12032,"version":3,"created":1554949052000,"modified":1555040404000,"deprecated":false,"name":"TNFAIP3-interacting protein 1","accession":"Q15025","gene":"TNIP1","description":"Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8064438272154788,"antibodyCount":200,"monoclonalCount":20,"pubmedCount":null,"jensenScore":70.523532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.86891203533424,"pubTatorScore":2.3039181055897755,"self":"https://pharos.nih.gov/idg/api/v1/targets(12032)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":503,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/properties"},"_links":{"count":1221,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12032)/publications"},"_namespace":null},{"id":12033,"version":3,"created":1554949058000,"modified":1555040407000,"deprecated":false,"name":"Exosome complex component RRP42","accession":"Q15024","gene":"EXOSC7","description":"Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8309092878204924,"antibodyCount":161,"monoclonalCount":80,"pubmedCount":null,"jensenScore":5.933013,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":34.33723666116247,"pubTatorScore":0.49202831431991734,"self":"https://pharos.nih.gov/idg/api/v1/targets(12033)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12033)/publications"},"_namespace":null},{"id":12034,"version":2,"created":1554949063000,"modified":1554949067000,"deprecated":false,"name":"Alpha-internexin","accession":"Q16352","gene":"INA","description":"Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0267852961886526,"antibodyCount":361,"monoclonalCount":113,"pubmedCount":null,"jensenScore":107.385663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.952871794240636,"pubTatorScore":2.303376070821689,"self":"https://pharos.nih.gov/idg/api/v1/targets(12034)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12034)/publications"},"_namespace":null},{"id":12035,"version":3,"created":1554949068000,"modified":1555040408000,"deprecated":false,"name":"Proepiregulin","accession":"O14944","gene":"EREG","description":"Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.282263775411276,"antibodyCount":187,"monoclonalCount":66,"pubmedCount":null,"jensenScore":183.262588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.318769377801196,"pubTatorScore":1.8179670614710959,"self":"https://pharos.nih.gov/idg/api/v1/targets(12035)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12035)/publications"},"_namespace":null},{"id":12036,"version":2,"created":1554949072000,"modified":1554949075000,"deprecated":false,"name":"Multimerin-2","accession":"Q9H8L6","gene":"MMRN2","description":"Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7312753147172617,"antibodyCount":82,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.931774,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.719264726142658,"pubTatorScore":1.038910203988243,"self":"https://pharos.nih.gov/idg/api/v1/targets(12036)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12036)/publications"},"_namespace":null},{"id":12037,"version":3,"created":1554949076000,"modified":1555040410000,"deprecated":false,"name":"Amyloid-beta A4 precursor protein-binding family A member 3","accession":"O96018","gene":"APBA3","description":"May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.185782646071723,"antibodyCount":125,"monoclonalCount":1,"pubmedCount":null,"jensenScore":15.270277,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":34.11346350478952,"pubTatorScore":1.14830138191507,"self":"https://pharos.nih.gov/idg/api/v1/targets(12037)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12037)/publications"},"_namespace":null},{"id":12038,"version":2,"created":1554949079000,"modified":1554949082000,"deprecated":false,"name":"Mdm2-binding protein","accession":"Q96DY7","gene":"MTBP","description":"Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3113081172210261,"antibodyCount":170,"monoclonalCount":31,"pubmedCount":null,"jensenScore":18.014851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.715290887714218,"pubTatorScore":1.1279527564403917,"self":"https://pharos.nih.gov/idg/api/v1/targets(12038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12038)/publications"},"_namespace":null},{"id":12039,"version":2,"created":1554949083000,"modified":1554949088000,"deprecated":false,"name":"116 kDa U5 small nuclear ribonucleoprotein component","accession":"Q15029","gene":"EFTUD2","description":"Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5728686446651288,"antibodyCount":177,"monoclonalCount":3,"pubmedCount":null,"jensenScore":38.572322,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.33675851688802,"pubTatorScore":1.3597383146746023,"self":"https://pharos.nih.gov/idg/api/v1/targets(12039)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12039)/publications"},"_namespace":null},{"id":12040,"version":2,"created":1554949089000,"modified":1554949116000,"deprecated":false,"name":"Serine/threonine-protein kinase Chk2","accession":"O96017","gene":"CHEK2","description":"Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.003037631023601,"antibodyCount":1374,"monoclonalCount":370,"pubmedCount":null,"jensenScore":978.735345,"patentCount":45013,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":57.844527465750296,"pubTatorScore":2.94709437054675,"self":"https://pharos.nih.gov/idg/api/v1/targets(12040)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/properties"},"_links":{"count":1554,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/links"},"_synonyms":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/synonyms"},"_publications":{"count":483,"href":"https://pharos.nih.gov/idg/api/v1/targets(12040)/publications"},"_namespace":null},{"id":12041,"version":3,"created":1554949118000,"modified":1555040413000,"deprecated":false,"name":"Dynein light chain 4, axonemal","accession":"O96015","gene":"DNAL4","description":"Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5481846073602816,"antibodyCount":171,"monoclonalCount":58,"pubmedCount":null,"jensenScore":3.316667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":30.09481797261799,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(12041)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12041)/publications"},"_namespace":null},{"id":12042,"version":2,"created":1554949121000,"modified":1554949125000,"deprecated":false,"name":"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1","accession":"Q15027","gene":"ACAP1","description":"GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1697260361728705,"antibodyCount":170,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.441871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.717243295581323,"pubTatorScore":1.22587295572761,"self":"https://pharos.nih.gov/idg/api/v1/targets(12042)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12042)/publications"},"_namespace":null},{"id":12043,"version":2,"created":1554949126000,"modified":1554949130000,"deprecated":false,"name":"Pumilio homolog 2","accession":"Q8TB72","gene":"PUM2","description":"Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.381336687575311,"antibodyCount":373,"monoclonalCount":127,"pubmedCount":null,"jensenScore":22.912999,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.983826363788886,"pubTatorScore":1.3995058021953481,"self":"https://pharos.nih.gov/idg/api/v1/targets(12043)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/properties"},"_links":{"count":1087,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12043)/publications"},"_namespace":null},{"id":12044,"version":3,"created":1554949131000,"modified":1555040414000,"deprecated":false,"name":"Cytochrome P450 2W1","accession":"Q8TAV3","gene":"CYP2W1","description":"Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4417260613318108,"antibodyCount":127,"monoclonalCount":16,"pubmedCount":null,"jensenScore":30.714423,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.567347031406364,"pubTatorScore":1.505180092883769,"self":"https://pharos.nih.gov/idg/api/v1/targets(12044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/properties"},"_links":{"count":822,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12044)/publications"},"_namespace":null},{"id":12045,"version":2,"created":1554949135000,"modified":1554949138000,"deprecated":false,"name":"Protein NDNF","accession":"Q8TB73","gene":"NDNF","description":"Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4179025315310128,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":249.239985,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.358646384192987,"pubTatorScore":1.1668246481692786,"self":"https://pharos.nih.gov/idg/api/v1/targets(12045)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12045)/properties"},"_links":{"count":799,"href":"https://pharos.nih.gov/idg/api/v1/targets(12045)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12045)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12045)/publications"},"_namespace":null},{"id":12046,"version":2,"created":1554949138000,"modified":1554949140000,"deprecated":false,"name":"Stomatin-like protein 3","accession":"Q8TAV4","gene":"STOML3","description":"Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4307080404714134,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":265.599896,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.96084323368866,"pubTatorScore":1.2568780157930977,"self":"https://pharos.nih.gov/idg/api/v1/targets(12046)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(12046)/properties"},"_links":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(12046)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12046)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12046)/publications"},"_namespace":null},{"id":12047,"version":3,"created":1554949141000,"modified":1555040415000,"deprecated":false,"name":"Putative uncharacterized protein C11orf45","accession":"Q8TAV5","gene":"C11orf45","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12047)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(12047)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(12047)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12047)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12047)/publications"},"_namespace":null},{"id":12048,"version":3,"created":1554949143000,"modified":1555040416000,"deprecated":false,"name":"Actin-like protein 6A","accession":"O96019","gene":"ACTL6A","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4547877952913282,"antibodyCount":286,"monoclonalCount":18,"pubmedCount":null,"jensenScore":28.324836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":45.160552962956714,"pubTatorScore":1.3487149510691427,"self":"https://pharos.nih.gov/idg/api/v1/targets(12048)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":483,"href":"https://pharos.nih.gov/idg/api/v1/targets(12048)/properties"},"_links":{"count":1173,"href":"https://pharos.nih.gov/idg/api/v1/targets(12048)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12048)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12048)/publications"},"_namespace":null},{"id":12049,"version":3,"created":1554949149000,"modified":1555040417000,"deprecated":false,"name":"Protein-lysine methyltransferase METTL21C","accession":"Q5VZV1","gene":"METTL21C","description":"Protein-lysine methyltransferase.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.20862048460642538,"antibodyCount":72,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.20202,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":11.0369011537931,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(12049)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(12049)/properties"},"_links":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(12049)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12049)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12049)/publications"},"_namespace":null},{"id":12050,"version":3,"created":1554949151000,"modified":1555040418000,"deprecated":false,"name":"Transmembrane protein C17orf113","accession":"A0A1B0GUU1","gene":"ZNF385C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12050)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(12050)/properties"},"_links":{"count":710,"href":"https://pharos.nih.gov/idg/api/v1/targets(12050)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12050)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12050)/publications"},"_namespace":null},{"id":12051,"version":3,"created":1554949154000,"modified":1555040419000,"deprecated":false,"name":"Protein Wnt-11","accession":"O96014","gene":"WNT11","description":"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.088460486657826,"antibodyCount":99,"monoclonalCount":4,"pubmedCount":null,"jensenScore":121.872684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.919807729245704,"pubTatorScore":1.7492549789236065,"self":"https://pharos.nih.gov/idg/api/v1/targets(12051)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(12051)/properties"},"_links":{"count":809,"href":"https://pharos.nih.gov/idg/api/v1/targets(12051)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12051)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12051)/publications"},"_namespace":null},{"id":12052,"version":3,"created":1554949159000,"modified":1555040420000,"deprecated":false,"name":"Serine/threonine-protein kinase PAK 4","accession":"O96013","gene":"PAK4","description":"Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.2326051521218666,"antibodyCount":436,"monoclonalCount":31,"pubmedCount":null,"jensenScore":194.691287,"patentCount":17386,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":45.13600383853167,"pubTatorScore":1.9514705557535375,"self":"https://pharos.nih.gov/idg/api/v1/targets(12052)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(12052)/properties"},"_links":{"count":1207,"href":"https://pharos.nih.gov/idg/api/v1/targets(12052)/links"},"_synonyms":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(12052)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12052)/publications"},"_namespace":null},{"id":12053,"version":3,"created":1554949180000,"modified":1554949232000,"deprecated":false,"name":"Cell division cycle 7-related protein kinase","accession":"O00311","gene":"CDC7","description":"Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.240647227483317,"antibodyCount":222,"monoclonalCount":54,"pubmedCount":null,"jensenScore":184.691916,"patentCount":13132,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.57143724852202,"pubTatorScore":1.958822982735421,"self":"https://pharos.nih.gov/idg/api/v1/targets(12053)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(12053)/properties"},"_links":{"count":1148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12053)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12053)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12053)/publications"},"_namespace":null},{"id":12054,"version":2,"created":1554949233000,"modified":1554949233000,"deprecated":false,"name":"Putative spermatogenesis-associated protein 31B1","accession":"Q5VZV4","gene":"SPATA31B1P","description":"May play a role in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.72300936750874,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12054)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12054)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12054)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12054)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12054)/publications"},"_namespace":null},{"id":12055,"version":2,"created":1554949233000,"modified":1554949238000,"deprecated":false,"name":"Peroxisomal membrane protein 11B","accession":"O96011","gene":"PEX11B","description":"Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0097138587948282,"antibodyCount":80,"monoclonalCount":11,"pubmedCount":null,"jensenScore":10.526543,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.602753374980516,"pubTatorScore":1.0642796297950765,"self":"https://pharos.nih.gov/idg/api/v1/targets(12055)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(12055)/properties"},"_links":{"count":1157,"href":"https://pharos.nih.gov/idg/api/v1/targets(12055)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12055)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12055)/publications"},"_namespace":null},{"id":12056,"version":2,"created":1554949239000,"modified":1554949242000,"deprecated":false,"name":"Cytochrome b-c1 complex subunit 10","accession":"O14957","gene":"UQCR11","description":"This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5900531045134282,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.537783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.1763582758855,"pubTatorScore":0.3810721005845232,"self":"https://pharos.nih.gov/idg/api/v1/targets(12056)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(12056)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(12056)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12056)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12056)/publications"},"_namespace":null},{"id":12057,"version":3,"created":1554949242000,"modified":1555040422000,"deprecated":false,"name":"Calsequestrin-2","accession":"O14958","gene":"CASQ2","description":"Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9379910607637545,"antibodyCount":204,"monoclonalCount":77,"pubmedCount":null,"jensenScore":89.38317,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":32,"knowledgeAvailability":33.27275698461117,"pubTatorScore":1.9219443438285955,"self":"https://pharos.nih.gov/idg/api/v1/targets(12057)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(12057)/properties"},"_links":{"count":1009,"href":"https://pharos.nih.gov/idg/api/v1/targets(12057)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12057)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12057)/publications"},"_namespace":null},{"id":12058,"version":3,"created":1554949247000,"modified":1555040425000,"deprecated":false,"name":"Uncharacterized protein C10orf88","accession":"Q9H8K7","gene":"C10orf88","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.21117141625131108,"antibodyCount":51,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.653846,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":0.0,"pubTatorScore":-0.007298944304662349,"self":"https://pharos.nih.gov/idg/api/v1/targets(12058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(12058)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(12058)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12058)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12058)/publications"},"_namespace":null},{"id":12059,"version":2,"created":1554949251000,"modified":1554949255000,"deprecated":false,"name":"R3H domain-containing protein 1","accession":"Q15032","gene":"R3HDM1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.40150994951987184,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.895991,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.92085951185208,"pubTatorScore":0.19629476358790166,"self":"https://pharos.nih.gov/idg/api/v1/targets(12059)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(12059)/properties"},"_links":{"count":861,"href":"https://pharos.nih.gov/idg/api/v1/targets(12059)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12059)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12059)/publications"},"_namespace":null},{"id":12060,"version":2,"created":1554949255000,"modified":1554949258000,"deprecated":false,"name":"IQ domain-containing protein D","accession":"Q96DY2","gene":"IQCD","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.12493873660829995,"antibodyCount":74,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.145390197154885,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12060)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(12060)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(12060)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12060)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12060)/publications"},"_namespace":null},{"id":12061,"version":2,"created":1554949258000,"modified":1554949262000,"deprecated":false,"name":"Probable leucine--tRNA ligase, mitochondrial","accession":"Q15031","gene":"LARS2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1188893604730112,"antibodyCount":120,"monoclonalCount":25,"pubmedCount":null,"jensenScore":130.982744,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.99365694087775,"pubTatorScore":1.3970148452912137,"self":"https://pharos.nih.gov/idg/api/v1/targets(12061)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(12061)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(12061)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12061)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12061)/publications"},"_namespace":null},{"id":12062,"version":2,"created":1554949263000,"modified":1554949265000,"deprecated":false,"name":"Protein FAM76A","accession":"Q8TAV0","gene":"FAM76A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":86,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.418475487103187,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12062)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(12062)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(12062)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12062)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12062)/publications"},"_namespace":null},{"id":12063,"version":2,"created":1554949266000,"modified":1554949268000,"deprecated":false,"name":"Myosin regulatory light chain 12B","accession":"O14950","gene":"MYL12A","description":"Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4884393394601965,"antibodyCount":135,"monoclonalCount":22,"pubmedCount":null,"jensenScore":28.910767,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.81178799835381,"pubTatorScore":0.7668464045529908,"self":"https://pharos.nih.gov/idg/api/v1/targets(12063)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12063)/publications"},"_namespace":null},{"id":12064,"version":2,"created":1554949270000,"modified":1554949273000,"deprecated":false,"name":"Sorting nexin-17","accession":"Q15036","gene":"SNX17","description":"Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.194138059568025,"antibodyCount":101,"monoclonalCount":8,"pubmedCount":null,"jensenScore":18.307999,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.46246629067845,"pubTatorScore":1.3388266814033123,"self":"https://pharos.nih.gov/idg/api/v1/targets(12064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/properties"},"_links":{"count":1131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12064)/publications"},"_namespace":null},{"id":12065,"version":2,"created":1554949273000,"modified":1554949277000,"deprecated":false,"name":"Translocating chain-associated membrane protein 2","accession":"Q15035","gene":"TRAM2","description":"Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.871884052184183,"antibodyCount":124,"monoclonalCount":13,"pubmedCount":null,"jensenScore":7.172592,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.04611699925198,"pubTatorScore":0.21967174306669981,"self":"https://pharos.nih.gov/idg/api/v1/targets(12065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12065)/publications"},"_namespace":null},{"id":12066,"version":3,"created":1554949278000,"modified":1555040426000,"deprecated":false,"name":"Laminin subunit alpha-4","accession":"Q16363","gene":"LAMA4","description":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1957329570159203,"antibodyCount":203,"monoclonalCount":41,"pubmedCount":null,"jensenScore":14.126024,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.211482507924075,"pubTatorScore":1.6305228907040605,"self":"https://pharos.nih.gov/idg/api/v1/targets(12066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12066)/publications"},"_namespace":null},{"id":12067,"version":3,"created":1554949284000,"modified":1555040428000,"deprecated":false,"name":"Probable E3 ubiquitin-protein ligase HERC3","accession":"Q15034","gene":"HERC3","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6454846485051143,"antibodyCount":175,"monoclonalCount":48,"pubmedCount":null,"jensenScore":4.43659,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.029015511527053,"pubTatorScore":0.6548180725420142,"self":"https://pharos.nih.gov/idg/api/v1/targets(12067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12067)/publications"},"_namespace":null},{"id":12068,"version":3,"created":1554949287000,"modified":1555040430000,"deprecated":false,"name":"Tripartite motif-containing protein 44","accession":"Q96DX7","gene":"TRIM44","description":"May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.700159427021992,"antibodyCount":187,"monoclonalCount":99,"pubmedCount":null,"jensenScore":49.027313,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":45,"knowledgeAvailability":39.570792622048096,"pubTatorScore":1.1290497061042186,"self":"https://pharos.nih.gov/idg/api/v1/targets(12068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12068)/publications"},"_namespace":null},{"id":12069,"version":3,"created":1554949292000,"modified":1555040432000,"deprecated":false,"name":"Aryl hydrocarbon receptor nuclear translocator-like protein 1","accession":"O00327","gene":"ARNTL","description":"Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.8354776239795623,"antibodyCount":330,"monoclonalCount":74,"pubmedCount":null,"jensenScore":672.891817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":50.701191464482314,"pubTatorScore":2.371301331661206,"self":"https://pharos.nih.gov/idg/api/v1/targets(12069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/properties"},"_links":{"count":1147,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/links"},"_synonyms":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/synonyms"},"_publications":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(12069)/publications"},"_namespace":null},{"id":12070,"version":2,"created":1554949298000,"modified":1554949304000,"deprecated":false,"name":"Histone-lysine N-methyltransferase NSD2","accession":"O96028","gene":"NSD2","description":"Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-2.4333645570685363,"antibodyCount":123,"monoclonalCount":12,"pubmedCount":null,"jensenScore":275.226599,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.9956247670179872,"self":"https://pharos.nih.gov/idg/api/v1/targets(12070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/properties"},"_links":{"count":1263,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/links"},"_synonyms":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12070)/publications"},"_namespace":null},{"id":12071,"version":4,"created":1554949306000,"modified":1555040434000,"deprecated":false,"name":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform","accession":"O00329","gene":"PIK3CD","description":"Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.85064230483579,"antibodyCount":423,"monoclonalCount":64,"pubmedCount":null,"jensenScore":709.242269,"patentCount":6395,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":51.77633472897743,"pubTatorScore":3.460271530483198,"self":"https://pharos.nih.gov/idg/api/v1/targets(12071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":605,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/properties"},"_links":{"count":1589,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12071)/publications"},"_namespace":null},{"id":12072,"version":2,"created":1554949463000,"modified":1554949463000,"deprecated":false,"name":"Testis-expressed protein 48","accession":"A0A1B0GUV7","gene":"TEX48","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/properties"},"_links":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12072)/publications"},"_namespace":null},{"id":12073,"version":2,"created":1554949464000,"modified":1554949466000,"deprecated":false,"name":"Receptor-transporting protein 4","accession":"Q96DX8","gene":"RTP4","description":"Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6840716803371287,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.577311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.184938407887106,"pubTatorScore":0.3232846968239614,"self":"https://pharos.nih.gov/idg/api/v1/targets(12073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12073)/publications"},"_namespace":null},{"id":12074,"version":2,"created":1554949467000,"modified":1554949469000,"deprecated":false,"name":"Proline-rich protein 7","accession":"Q8TB68","gene":"PRR7","description":"Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8553172167771292,"antibodyCount":100,"monoclonalCount":22,"pubmedCount":null,"jensenScore":7.493382,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.834944671322184,"pubTatorScore":-0.25218128028125936,"self":"https://pharos.nih.gov/idg/api/v1/targets(12074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(12074)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(12074)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12074)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12074)/publications"},"_namespace":null},{"id":12075,"version":2,"created":1554949470000,"modified":1554949473000,"deprecated":false,"name":"DAZ-associated protein 2","accession":"Q15038","gene":"DAZAP2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.421466798323904,"antibodyCount":81,"monoclonalCount":10,"pubmedCount":null,"jensenScore":28.26162,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.58872384178551,"pubTatorScore":1.1678445494589427,"self":"https://pharos.nih.gov/idg/api/v1/targets(12075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(12075)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(12075)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12075)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12075)/publications"},"_namespace":null},{"id":12076,"version":3,"created":1554949474000,"modified":1555040437000,"deprecated":false,"name":"Killer cell lectin-like receptor subfamily G member 1","accession":"Q96E93","gene":"KLRG1","description":"Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0576486178288373,"antibodyCount":304,"monoclonalCount":181,"pubmedCount":null,"jensenScore":118.973023,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.96136479702484,"pubTatorScore":1.7428323644563626,"self":"https://pharos.nih.gov/idg/api/v1/targets(12076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12076)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(12076)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12076)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12076)/publications"},"_namespace":null},{"id":12077,"version":2,"created":1554949476000,"modified":1554949480000,"deprecated":false,"name":"Adenosine 3'-phospho 5'-phosphosulfate transporter 1","accession":"Q8TB61","gene":"SLC35B2","description":"Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.308414629512225,"antibodyCount":77,"monoclonalCount":4,"pubmedCount":null,"jensenScore":191.501148,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.90104643511813,"pubTatorScore":1.9297923146131681,"self":"https://pharos.nih.gov/idg/api/v1/targets(12077)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(12077)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(12077)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12077)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12077)/publications"},"_namespace":null},{"id":12078,"version":2,"created":1554949481000,"modified":1554949483000,"deprecated":false,"name":"Zinc finger protein 417","accession":"Q8TAU3","gene":"ZNF417","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.5890950140319904,"antibodyCount":83,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.148352,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.501153065988827,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(12078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12078)/properties"},"_links":{"count":847,"href":"https://pharos.nih.gov/idg/api/v1/targets(12078)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12078)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12078)/publications"},"_namespace":null},{"id":12079,"version":3,"created":1554949483000,"modified":1555040439000,"deprecated":false,"name":"Ankyrin repeat and SOCS box protein 9","accession":"Q96DX5","gene":"ASB9","description":"Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7242596086169313,"antibodyCount":130,"monoclonalCount":11,"pubmedCount":null,"jensenScore":7.254888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":26.771557364806803,"pubTatorScore":1.058172852661461,"self":"https://pharos.nih.gov/idg/api/v1/targets(12079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(12079)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(12079)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12079)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12079)/publications"},"_namespace":null},{"id":12080,"version":3,"created":1554949487000,"modified":1555040440000,"deprecated":false,"name":"RING finger and SPRY domain-containing protein 1","accession":"Q96DX4","gene":"RSPRY1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.17609125688420882,"antibodyCount":77,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.642857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":27.35396753744043,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(12080)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(12080)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12080)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12080)/publications"},"_namespace":null},{"id":12081,"version":2,"created":1554949491000,"modified":1554949492000,"deprecated":false,"name":"Putative microRNA 17 host gene protein","accession":"Q75NE6","gene":"MIR17HG","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.526484035992508,"pubTatorScore":1.469699321498559,"self":"https://pharos.nih.gov/idg/api/v1/targets(12081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12081)/properties"},"_links":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12081)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12081)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12081)/publications"},"_namespace":null},{"id":12082,"version":3,"created":1554949493000,"modified":1555040442000,"deprecated":false,"name":"G1/S-specific cyclin-E2","accession":"O96020","gene":"CCNE2","description":"Essential for the control of the cell cycle at the late G1 and early S phase.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8411835456021914,"antibodyCount":225,"monoclonalCount":24,"pubmedCount":null,"jensenScore":53.845839,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":46.698854332332516,"pubTatorScore":1.7130541645869986,"self":"https://pharos.nih.gov/idg/api/v1/targets(12082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(12082)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(12082)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12082)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(12082)/publications"},"_namespace":null},{"id":12083,"version":2,"created":1554949498000,"modified":1554949501000,"deprecated":false,"name":"ETS translocation variant 2","accession":"O00321","gene":"ETV2","description":"Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6406273162297431,"antibodyCount":137,"monoclonalCount":5,"pubmedCount":null,"jensenScore":48.699871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.201774222767316,"pubTatorScore":1.1577277172020348,"self":"https://pharos.nih.gov/idg/api/v1/targets(12083)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12083)/properties"},"_links":{"count":750,"href":"https://pharos.nih.gov/idg/api/v1/targets(12083)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12083)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12083)/publications"},"_namespace":null},{"id":12084,"version":2,"created":1554949502000,"modified":1554949506000,"deprecated":false,"name":"Zinc finger protein 519","accession":"Q8TB69","gene":"ZNF519","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.03855998022574,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(12084)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(12084)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(12084)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12084)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12084)/publications"},"_namespace":null},{"id":12085,"version":2,"created":1554949507000,"modified":1554949511000,"deprecated":false,"name":"Hepcidin","accession":"P81172","gene":"HAMP","description":"Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3089096628656383,"antibodyCount":306,"monoclonalCount":25,"pubmedCount":null,"jensenScore":2214.414054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.89391710736819,"pubTatorScore":2.4960070267060916,"self":"https://pharos.nih.gov/idg/api/v1/targets(12085)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":608,"href":"https://pharos.nih.gov/idg/api/v1/targets(12085)/properties"},"_links":{"count":1142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12085)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12085)/synonyms"},"_publications":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(12085)/publications"},"_namespace":null},{"id":12086,"version":2,"created":1554949513000,"modified":1554949516000,"deprecated":false,"name":"Beta-1,3-galactosyltransferase 4","accession":"O96024","gene":"B3GALT4","description":"Involved in GM1/GD1B/GA1 ganglioside biosynthesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4797506432755687,"antibodyCount":66,"monoclonalCount":3,"pubmedCount":null,"jensenScore":33.283867,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.364785576537244,"pubTatorScore":1.2516768307958828,"self":"https://pharos.nih.gov/idg/api/v1/targets(12086)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(12086)/properties"},"_links":{"count":785,"href":"https://pharos.nih.gov/idg/api/v1/targets(12086)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12086)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12086)/publications"},"_namespace":null},{"id":12087,"version":3,"created":1554949517000,"modified":1555040445000,"deprecated":false,"name":"Uroplakin-1a","accession":"O00322","gene":"UPK1A","description":"Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.590415296910834,"antibodyCount":77,"monoclonalCount":0,"pubmedCount":null,"jensenScore":36.231708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":79,"knowledgeAvailability":21.039416630403824,"pubTatorScore":1.3985780742102496,"self":"https://pharos.nih.gov/idg/api/v1/targets(12087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(12087)/properties"},"_links":{"count":742,"href":"https://pharos.nih.gov/idg/api/v1/targets(12087)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12087)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12087)/publications"},"_namespace":null},{"id":12088,"version":2,"created":1554949520000,"modified":1554949520000,"deprecated":false,"name":"Endogenous retrovirus group K member 8 Env polyprotein","accession":"Q902F8","gene":"ERVK-8","description":"TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12088)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12088)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12088)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12088)/publications"},"_namespace":null},{"id":12089,"version":2,"created":1554949520000,"modified":1554949521000,"deprecated":false,"name":"Endogenous retrovirus group K member 113 Env polyprotein","accession":"Q902F9","gene":"HERVK_113","description":"TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12089)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12089)/links"},"_synonyms":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12089)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12089)/publications"},"_namespace":null},{"id":12090,"version":2,"created":1554949521000,"modified":1554949525000,"deprecated":false,"name":"Calmegin","accession":"O14967","gene":"CLGN","description":"Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0987261158205275,"antibodyCount":132,"monoclonalCount":63,"pubmedCount":null,"jensenScore":13.813907,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.091296161861834,"pubTatorScore":0.9450306724016776,"self":"https://pharos.nih.gov/idg/api/v1/targets(12090)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12090)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(12090)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12090)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12090)/publications"},"_namespace":null},{"id":12091,"version":2,"created":1554949526000,"modified":1554949529000,"deprecated":false,"name":"Josephin-1","accession":"Q15040","gene":"JOSD1","description":"Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4190039471911342,"antibodyCount":43,"monoclonalCount":7,"pubmedCount":null,"jensenScore":2.722158,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.149889656822975,"pubTatorScore":-0.09732170209818049,"self":"https://pharos.nih.gov/idg/api/v1/targets(12091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(12091)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(12091)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12091)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12091)/publications"},"_namespace":null},{"id":12092,"version":2,"created":1554949529000,"modified":1554949531000,"deprecated":false,"name":"Leukocyte cell-derived chemotaxin-2","accession":"O14960","gene":"LECT2","description":"Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9035130220664314,"antibodyCount":177,"monoclonalCount":50,"pubmedCount":null,"jensenScore":86.216183,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.502584372689128,"pubTatorScore":1.7857900998121405,"self":"https://pharos.nih.gov/idg/api/v1/targets(12092)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(12092)/properties"},"_links":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(12092)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12092)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12092)/publications"},"_namespace":null},{"id":12093,"version":2,"created":1554949531000,"modified":1554949536000,"deprecated":false,"name":"Zinc transporter ZIP14","accession":"Q15043","gene":"SLC39A14","description":"Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.6871943025610714,"antibodyCount":117,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.462871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.00617902050749,"pubTatorScore":1.4603938439627608,"self":"https://pharos.nih.gov/idg/api/v1/targets(12093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12093)/publications"},"_namespace":null},{"id":12094,"version":3,"created":1554949537000,"modified":1555040446000,"deprecated":false,"name":"Rab3 GTPase-activating protein catalytic subunit","accession":"Q15042","gene":"RAB3GAP1","description":"Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4065351556758678,"antibodyCount":104,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.028538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.61391170343331,"pubTatorScore":1.4690243608989935,"self":"https://pharos.nih.gov/idg/api/v1/targets(12094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/properties"},"_links":{"count":1274,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12094)/publications"},"_namespace":null},{"id":12095,"version":2,"created":1554949544000,"modified":1554949546000,"deprecated":false,"name":"Proline-rich protein 4","accession":"Q16378","gene":"PRR4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.643914264039466,"antibodyCount":12,"monoclonalCount":4,"pubmedCount":null,"jensenScore":49.405601,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.907348014033623,"pubTatorScore":1.1798872919000007,"self":"https://pharos.nih.gov/idg/api/v1/targets(12095)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12095)/publications"},"_namespace":null},{"id":12096,"version":2,"created":1554949546000,"modified":1554949549000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 6-interacting protein 1","accession":"Q15041","gene":"ARL6IP1","description":"Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.020433643873573,"antibodyCount":217,"monoclonalCount":16,"pubmedCount":null,"jensenScore":14.287801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.199070993732924,"pubTatorScore":0.9230465200336901,"self":"https://pharos.nih.gov/idg/api/v1/targets(12096)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12096)/publications"},"_namespace":null},{"id":12097,"version":2,"created":1554949550000,"modified":1554949552000,"deprecated":false,"name":"Homeobox protein Nkx-2.3","accession":"Q8TAU0","gene":"NKX2-3","description":"Transcription factor.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4730144151912985,"antibodyCount":63,"monoclonalCount":6,"pubmedCount":null,"jensenScore":30.674484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.560228242089867,"pubTatorScore":1.2410435135186657,"self":"https://pharos.nih.gov/idg/api/v1/targets(12097)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/properties"},"_links":{"count":504,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12097)/publications"},"_namespace":null},{"id":12098,"version":2,"created":1554949552000,"modified":1554949555000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 14","accession":"Q15048","gene":"LRRC14","description":"Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.14483356559667326,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.7625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.915535001987042,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12098)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12098)/publications"},"_namespace":null},{"id":12099,"version":3,"created":1554949555000,"modified":1555040448000,"deprecated":false,"name":"Hepatocyte growth factor-regulated tyrosine kinase substrate","accession":"O14964","gene":"HGS","description":"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7664302887290226,"antibodyCount":379,"monoclonalCount":76,"pubmedCount":null,"jensenScore":560.075163,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":47.84510755398793,"pubTatorScore":1.7099258269512612,"self":"https://pharos.nih.gov/idg/api/v1/targets(12099)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/synonyms"},"_publications":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12099)/publications"},"_namespace":null},{"id":12100,"version":3,"created":1554949560000,"modified":1555040450000,"deprecated":false,"name":"Histone-lysine N-methyltransferase SETDB1","accession":"Q15047","gene":"SETDB1","description":"Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-2.25204391715242,"antibodyCount":274,"monoclonalCount":76,"pubmedCount":null,"jensenScore":181.608916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":43.298845317809324,"pubTatorScore":1.8205644200082693,"self":"https://pharos.nih.gov/idg/api/v1/targets(12100)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12100)/publications"},"_namespace":null},{"id":12101,"version":3,"created":1554949567000,"modified":1555040456000,"deprecated":false,"name":"MANSC domain-containing protein 1","accession":"Q9H8J5","gene":"MANSC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.1646114427940486,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.56908,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":87,"knowledgeAvailability":28.846046560876356,"pubTatorScore":-0.4623357679583681,"self":"https://pharos.nih.gov/idg/api/v1/targets(12101)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12101)/publications"},"_namespace":null},{"id":12102,"version":3,"created":1554949572000,"modified":1555040457000,"deprecated":false,"name":"Ras-related protein Rab-7L1","accession":"O14966","gene":"RAB29","description":"Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1606845763872555,"antibodyCount":122,"monoclonalCount":28,"pubmedCount":null,"jensenScore":15.337606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.66650738461715,"pubTatorScore":1.1374621017897004,"self":"https://pharos.nih.gov/idg/api/v1/targets(12102)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12102)/publications"},"_namespace":null},{"id":12103,"version":3,"created":1554949577000,"modified":1555040459000,"deprecated":false,"name":"Lysine--tRNA ligase","accession":"Q15046","gene":"KARS","description":"(Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.457160884891776,"antibodyCount":150,"monoclonalCount":37,"pubmedCount":null,"jensenScore":282.493895,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":48.121272367966085,"pubTatorScore":2.14336823147521,"self":"https://pharos.nih.gov/idg/api/v1/targets(12103)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/properties"},"_links":{"count":1257,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12103)/publications"},"_namespace":null},{"id":12104,"version":4,"created":1554949597000,"modified":1555040466000,"deprecated":false,"name":"Aurora kinase A","accession":"O14965","gene":"AURKA","description":"Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.083472359245035,"antibodyCount":702,"monoclonalCount":179,"pubmedCount":null,"jensenScore":1158.019468,"patentCount":76823,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":56.538258505540014,"pubTatorScore":2.982113826149861,"self":"https://pharos.nih.gov/idg/api/v1/targets(12104)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/properties"},"_links":{"count":2492,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/links"},"_synonyms":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/synonyms"},"_publications":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(12104)/publications"},"_namespace":null},{"id":12105,"version":2,"created":1554949859000,"modified":1554949862000,"deprecated":false,"name":"Solute carrier family 25 member 38","accession":"Q96DW6","gene":"SLC25A38","description":"Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.1211361886859879,"antibodyCount":74,"monoclonalCount":5,"pubmedCount":null,"jensenScore":12.181746,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.181745995601037,"pubTatorScore":1.111175074520842,"self":"https://pharos.nih.gov/idg/api/v1/targets(12105)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12105)/publications"},"_namespace":null},{"id":12106,"version":3,"created":1554949863000,"modified":1555040472000,"deprecated":false,"name":"Sulfotransferase 1C2","accession":"O00338","gene":"SULT1C2","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.256366392771483,"antibodyCount":167,"monoclonalCount":55,"pubmedCount":null,"jensenScore":118.686634,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.00383802766088,"pubTatorScore":1.139107055836804,"self":"https://pharos.nih.gov/idg/api/v1/targets(12106)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12106)/publications"},"_namespace":null},{"id":12107,"version":2,"created":1554949867000,"modified":1554949870000,"deprecated":false,"name":"Endonuclease 8-like 3","accession":"Q8TAT5","gene":"NEIL3","description":"DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5390207158803821,"antibodyCount":137,"monoclonalCount":12,"pubmedCount":null,"jensenScore":37.441621,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.531582043224102,"pubTatorScore":1.61977858872974,"self":"https://pharos.nih.gov/idg/api/v1/targets(12107)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(12107)/properties"},"_links":{"count":640,"href":"https://pharos.nih.gov/idg/api/v1/targets(12107)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12107)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12107)/publications"},"_namespace":null},{"id":12108,"version":2,"created":1554949870000,"modified":1554949873000,"deprecated":false,"name":"Sodium/nucleoside cotransporter 1","accession":"O00337","gene":"SLC28A1","description":"Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.9428559716109537,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":85.531448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.312773921599376,"pubTatorScore":1.912215890251198,"self":"https://pharos.nih.gov/idg/api/v1/targets(12108)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(12108)/properties"},"_links":{"count":785,"href":"https://pharos.nih.gov/idg/api/v1/targets(12108)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12108)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12108)/publications"},"_namespace":null},{"id":12109,"version":2,"created":1554949874000,"modified":1554949878000,"deprecated":false,"name":"Nuclear protein localization protein 4 homolog","accession":"Q8TAT6","gene":"NPLOC4","description":"The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.551895618089758,"antibodyCount":100,"monoclonalCount":3,"pubmedCount":null,"jensenScore":28.241197,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.67971405648309,"pubTatorScore":1.4357527055304011,"self":"https://pharos.nih.gov/idg/api/v1/targets(12109)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(12109)/properties"},"_links":{"count":1117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12109)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12109)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12109)/publications"},"_namespace":null},{"id":12110,"version":3,"created":1554949879000,"modified":1555040473000,"deprecated":false,"name":"Matrilin-2","accession":"O00339","gene":"MATN2","description":"Involved in matrix assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3719584400461537,"antibodyCount":121,"monoclonalCount":11,"pubmedCount":null,"jensenScore":28.597407,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":36.2303566935156,"pubTatorScore":1.254971289829154,"self":"https://pharos.nih.gov/idg/api/v1/targets(12110)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(12110)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(12110)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(12110)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12110)/publications"},"_namespace":null},{"id":12111,"version":3,"created":1554949884000,"modified":1555040475000,"deprecated":false,"name":"Membrane protein MLC1","accession":"Q15049","gene":"MLC1","description":"Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.3027000247252327,"antibodyCount":119,"monoclonalCount":0,"pubmedCount":null,"jensenScore":197.734119,"patentCount":11070,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":30.27481288275981,"pubTatorScore":2.9008260206171848,"self":"https://pharos.nih.gov/idg/api/v1/targets(12111)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(12111)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(12111)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12111)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(12111)/publications"},"_namespace":null},{"id":12112,"version":3,"created":1554949889000,"modified":1555040476000,"deprecated":false,"name":"F-box only protein 30","accession":"Q8TB52","gene":"FBXO30","description":"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":29,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.423077,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.15731822551307,"pubTatorScore":0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12112)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12112)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(12112)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12112)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12112)/publications"},"_namespace":null},{"id":12113,"version":2,"created":1554949893000,"modified":1554949896000,"deprecated":false,"name":"Fibroblast growth factor-binding protein 3","accession":"Q8TAT2","gene":"FGFBP3","description":"Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5348115090707892,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.41978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.24873281400712,"pubTatorScore":0.3373078807877475,"self":"https://pharos.nih.gov/idg/api/v1/targets(12113)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(12113)/properties"},"_links":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(12113)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12113)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12113)/publications"},"_namespace":null},{"id":12114,"version":3,"created":1554949896000,"modified":1555040478000,"deprecated":false,"name":"Exportin-1","accession":"O14980","gene":"XPO1","description":"Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1438513617529638,"antibodyCount":200,"monoclonalCount":7,"pubmedCount":null,"jensenScore":1273.6009,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":55.029611257854924,"pubTatorScore":2.833263261544163,"self":"https://pharos.nih.gov/idg/api/v1/targets(12114)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":751,"href":"https://pharos.nih.gov/idg/api/v1/targets(12114)/properties"},"_links":{"count":1422,"href":"https://pharos.nih.gov/idg/api/v1/targets(12114)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12114)/synonyms"},"_publications":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(12114)/publications"},"_namespace":null},{"id":12115,"version":3,"created":1554949904000,"modified":1555040481000,"deprecated":false,"name":"Pyruvate dehydrogenase protein X component, mitochondrial","accession":"O00330","gene":"PDHX","description":"Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4483329090548946,"antibodyCount":215,"monoclonalCount":2,"pubmedCount":null,"jensenScore":258.656221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.81087053792138,"pubTatorScore":1.9800350580084138,"self":"https://pharos.nih.gov/idg/api/v1/targets(12115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(12115)/properties"},"_links":{"count":1188,"href":"https://pharos.nih.gov/idg/api/v1/targets(12115)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12115)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(12115)/publications"},"_namespace":null},{"id":12116,"version":2,"created":1554949910000,"modified":1554949910000,"deprecated":false,"name":"Putative uncharacterized protein LOC644613","accession":"Q8TAT8","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12116)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12116)/links"},"_synonyms":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12116)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12116)/publications"},"_namespace":null},{"id":12117,"version":2,"created":1554949910000,"modified":1554949911000,"deprecated":false,"name":"Putative uncharacterized protein C10orf113","accession":"Q5VZT2","gene":"C10orf113","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12117)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12117)/properties"},"_links":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(12117)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12117)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12117)/publications"},"_namespace":null},{"id":12118,"version":3,"created":1554949911000,"modified":1555040482000,"deprecated":false,"name":"Molybdopterin synthase sulfur carrier subunit","accession":"O96033","gene":"MOCS2","description":"Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0548328666571187,"antibodyCount":92,"monoclonalCount":6,"pubmedCount":null,"jensenScore":207.619923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.4637863573473329,"self":"https://pharos.nih.gov/idg/api/v1/targets(12118)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(12118)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(12118)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12118)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12118)/publications"},"_namespace":null},{"id":12119,"version":3,"created":1554949917000,"modified":1555040484000,"deprecated":false,"name":"Heterogeneous nuclear ribonucleoprotein D-like","accession":"O14979","gene":"HNRNPDL","description":"Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0420274750323528,"antibodyCount":104,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.058481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":42.22772235711075,"pubTatorScore":2.004199427412688,"self":"https://pharos.nih.gov/idg/api/v1/targets(12119)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(12119)/properties"},"_links":{"count":1173,"href":"https://pharos.nih.gov/idg/api/v1/targets(12119)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12119)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12119)/publications"},"_namespace":null},{"id":12120,"version":3,"created":1554949922000,"modified":1555040488000,"deprecated":false,"name":"Zinc finger protein 263","accession":"O14978","gene":"ZNF263","description":"Might play an important role in basic cellular processes as a transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.6313866521006551,"antibodyCount":202,"monoclonalCount":73,"pubmedCount":null,"jensenScore":3.549484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":35.6976625246926,"pubTatorScore":0.790967392320691,"self":"https://pharos.nih.gov/idg/api/v1/targets(12120)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(12120)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(12120)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12120)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12120)/publications"},"_namespace":null},{"id":12121,"version":2,"created":1554949926000,"modified":1554949930000,"deprecated":false,"name":"Protein dopey-1","accession":"Q5JWR5","gene":"DOPEY1","description":"May be involved in protein traffic between late Golgi and early endosomes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.184691411708642,"antibodyCount":22,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.44863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.319609404871528,"pubTatorScore":0.06694691371473312,"self":"https://pharos.nih.gov/idg/api/v1/targets(12121)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(12121)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(12121)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12121)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12121)/publications"},"_namespace":null},{"id":12122,"version":3,"created":1554949931000,"modified":1555040489000,"deprecated":false,"name":"IQ calmodulin-binding motif-containing protein 1","accession":"Q15051","gene":"IQCB1","description":"Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6478174818886375,"antibodyCount":129,"monoclonalCount":3,"pubmedCount":null,"jensenScore":44.397058,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.87525008141712,"pubTatorScore":1.421638109764446,"self":"https://pharos.nih.gov/idg/api/v1/targets(12122)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(12122)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(12122)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12122)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12122)/publications"},"_namespace":null},{"id":12123,"version":3,"created":1554949936000,"modified":1555040494000,"deprecated":false,"name":"Ribosome biogenesis regulatory protein homolog","accession":"Q15050","gene":"RRS1","description":"Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7950773148236596,"antibodyCount":148,"monoclonalCount":2,"pubmedCount":null,"jensenScore":593.040914,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":102,"knowledgeAvailability":37.983339061257574,"pubTatorScore":1.4255807775011953,"self":"https://pharos.nih.gov/idg/api/v1/targets(12123)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(12123)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(12123)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12123)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12123)/publications"},"_namespace":null},{"id":12124,"version":3,"created":1554949939000,"modified":1555040495000,"deprecated":false,"name":"DNA polymerase delta subunit 3","accession":"Q15054","gene":"POLD3","description":"As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the POLZ complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3170417218815909,"antibodyCount":144,"monoclonalCount":14,"pubmedCount":null,"jensenScore":19.968854,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.81475802900548,"pubTatorScore":2.3710430587283855,"self":"https://pharos.nih.gov/idg/api/v1/targets(12124)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(12124)/properties"},"_links":{"count":1016,"href":"https://pharos.nih.gov/idg/api/v1/targets(12124)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12124)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12124)/publications"},"_namespace":null},{"id":12125,"version":2,"created":1554949944000,"modified":1554949947000,"deprecated":false,"name":"Uncharacterized protein KIAA0040","accession":"Q15053","gene":"KIAA0040","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.210171451297004,"pubTatorScore":0.5614420041704278,"self":"https://pharos.nih.gov/idg/api/v1/targets(12125)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12125)/properties"},"_links":{"count":751,"href":"https://pharos.nih.gov/idg/api/v1/targets(12125)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12125)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12125)/publications"},"_namespace":null},{"id":12126,"version":2,"created":1554949947000,"modified":1554949950000,"deprecated":false,"name":"Down syndrome critical region protein 3","accession":"O14972","gene":"VPS26C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0919599050531397,"antibodyCount":97,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.717064,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.9341375339000757,"self":"https://pharos.nih.gov/idg/api/v1/targets(12126)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(12126)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(12126)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12126)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12126)/publications"},"_namespace":null},{"id":12127,"version":3,"created":1554949951000,"modified":1555040496000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 6","accession":"Q15052","gene":"ARHGEF6","description":"Acts as a RAC1 guanine nucleotide exchange factor (GEF).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5995766863973266,"antibodyCount":119,"monoclonalCount":22,"pubmedCount":null,"jensenScore":41.128679,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.11374364627391,"pubTatorScore":1.3818820479171656,"self":"https://pharos.nih.gov/idg/api/v1/targets(12127)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":393,"href":"https://pharos.nih.gov/idg/api/v1/targets(12127)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(12127)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12127)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(12127)/publications"},"_namespace":null},{"id":12128,"version":2,"created":1554949957000,"modified":1554949960000,"deprecated":false,"name":"INO80 complex subunit D","accession":"Q53TQ3","gene":"INO80D","description":"Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3937840530370178,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.296703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.692700580076494,"pubTatorScore":-0.057991946977686754,"self":"https://pharos.nih.gov/idg/api/v1/targets(12128)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(12128)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(12128)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12128)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12128)/publications"},"_namespace":null},{"id":12129,"version":2,"created":1554949961000,"modified":1554949965000,"deprecated":false,"name":"Very long-chain acyl-CoA synthetase","accession":"O14975","gene":"SLC27A2","description":"Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.7325124079093388,"antibodyCount":121,"monoclonalCount":31,"pubmedCount":null,"jensenScore":54.656937,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.543735273329226,"pubTatorScore":1.4336436862507924,"self":"https://pharos.nih.gov/idg/api/v1/targets(12129)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(12129)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(12129)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12129)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12129)/publications"},"_namespace":null},{"id":12130,"version":4,"created":1554949966000,"modified":1555040498000,"deprecated":false,"name":"Bromodomain-containing protein 3","accession":"Q15059","gene":"BRD3","description":"Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.26289406576467,"antibodyCount":276,"monoclonalCount":44,"pubmedCount":null,"jensenScore":177.193373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.56957613642524,"pubTatorScore":1.4010264728628663,"self":"https://pharos.nih.gov/idg/api/v1/targets(12130)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(12130)/properties"},"_links":{"count":1315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12130)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12130)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12130)/publications"},"_namespace":null},{"id":12131,"version":3,"created":1554949989000,"modified":1555040499000,"deprecated":false,"name":"Kinesin-like protein KIF14","accession":"Q15058","gene":"KIF14","description":"Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4603680839532203,"antibodyCount":93,"monoclonalCount":3,"pubmedCount":null,"jensenScore":34.019247,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.266822374557194,"pubTatorScore":1.5181337131679604,"self":"https://pharos.nih.gov/idg/api/v1/targets(12131)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(12131)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(12131)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12131)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12131)/publications"},"_namespace":null},{"id":12132,"version":2,"created":1554949994000,"modified":1554949995000,"deprecated":false,"name":"Protein SSX1","accession":"Q16384","gene":"SSX1","description":"Could act as a modulator of transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.098060243764341,"antibodyCount":104,"monoclonalCount":47,"pubmedCount":null,"jensenScore":102.774518,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.40779539478418,"pubTatorScore":1.8981360993708836,"self":"https://pharos.nih.gov/idg/api/v1/targets(12132)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(12132)/properties"},"_links":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(12132)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12132)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12132)/publications"},"_namespace":null},{"id":12133,"version":3,"created":1554949996000,"modified":1555040501000,"deprecated":false,"name":"Protein phosphatase 1 regulatory subunit 12A","accession":"O14974","gene":"PPP1R12A","description":"Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.12546020292899,"antibodyCount":406,"monoclonalCount":23,"pubmedCount":null,"jensenScore":1290.646987,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":53.1267380142,"pubTatorScore":2.1103879285938656,"self":"https://pharos.nih.gov/idg/api/v1/targets(12133)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":534,"href":"https://pharos.nih.gov/idg/api/v1/targets(12133)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12133)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12133)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12133)/publications"},"_namespace":null},{"id":12134,"version":2,"created":1554950002000,"modified":1554950006000,"deprecated":false,"name":"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2","accession":"Q15057","gene":"ACAP2","description":"GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7859986790436717,"antibodyCount":147,"monoclonalCount":36,"pubmedCount":null,"jensenScore":6.361521,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.88718339475266,"pubTatorScore":0.5687601961941223,"self":"https://pharos.nih.gov/idg/api/v1/targets(12134)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(12134)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(12134)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12134)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12134)/publications"},"_namespace":null},{"id":12135,"version":3,"created":1554950007000,"modified":1555040503000,"deprecated":false,"name":"Antizyme inhibitor 1","accession":"O14977","gene":"AZIN1","description":"Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2758791930138758,"antibodyCount":107,"monoclonalCount":48,"pubmedCount":null,"jensenScore":17.697086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":38.89919467915967,"pubTatorScore":1.2670040114017134,"self":"https://pharos.nih.gov/idg/api/v1/targets(12135)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(12135)/properties"},"_links":{"count":1004,"href":"https://pharos.nih.gov/idg/api/v1/targets(12135)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12135)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12135)/publications"},"_namespace":null},{"id":12136,"version":2,"created":1554950012000,"modified":1554950013000,"deprecated":false,"name":"Protein SSX2","accession":"Q16385","gene":"SSX2B","description":"Could act as a modulator of transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.354896199000036,"antibodyCount":165,"monoclonalCount":31,"pubmedCount":null,"jensenScore":240.555134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.715977292440244,"pubTatorScore":1.5081715241129343,"self":"https://pharos.nih.gov/idg/api/v1/targets(12136)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(12136)/properties"},"_links":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(12136)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12136)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12136)/publications"},"_namespace":null},{"id":12137,"version":2,"created":1554950013000,"modified":1554950017000,"deprecated":false,"name":"Eukaryotic translation initiation factor 4H","accession":"Q15056","gene":"EIF4H","description":"Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.2612092975294136,"antibodyCount":147,"monoclonalCount":10,"pubmedCount":null,"jensenScore":18.509157,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.68812562175084,"pubTatorScore":1.3432444171880187,"self":"https://pharos.nih.gov/idg/api/v1/targets(12137)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(12137)/properties"},"_links":{"count":1149,"href":"https://pharos.nih.gov/idg/api/v1/targets(12137)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12137)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12137)/publications"},"_namespace":null},{"id":12138,"version":2,"created":1554950018000,"modified":1554950039000,"deprecated":false,"name":"Cyclin-G-associated kinase","accession":"O14976","gene":"GAK","description":"Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.857472257509734,"antibodyCount":231,"monoclonalCount":17,"pubmedCount":null,"jensenScore":68.225225,"patentCount":4409,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.62687322575355,"pubTatorScore":1.6675764897631837,"self":"https://pharos.nih.gov/idg/api/v1/targets(12138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":453,"href":"https://pharos.nih.gov/idg/api/v1/targets(12138)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12138)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12138)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12138)/publications"},"_namespace":null},{"id":12139,"version":2,"created":1554950040000,"modified":1554950043000,"deprecated":false,"name":"Uncharacterized protein C12orf60","accession":"Q5U649","gene":"C12orf60","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.3424226808222062,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.038462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-1.2787501266108712,"self":"https://pharos.nih.gov/idg/api/v1/targets(12139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(12139)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(12139)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12139)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12139)/publications"},"_namespace":null},{"id":12140,"version":2,"created":1554950043000,"modified":1554950044000,"deprecated":false,"name":"Putative uncharacterized protein encoded by HEXA-AS1","accession":"Q9H8Q6","gene":"HEXA-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.53141392719118,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12140)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12140)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12140)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12140)/publications"},"_namespace":null},{"id":12141,"version":2,"created":1554950044000,"modified":1554950046000,"deprecated":false,"name":"Protein FAM182B","accession":"Q5T319","gene":"FAM182B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.398009366142897,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12141)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(12141)/properties"},"_links":{"count":746,"href":"https://pharos.nih.gov/idg/api/v1/targets(12141)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12141)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12141)/publications"},"_namespace":null},{"id":12142,"version":2,"created":1554950047000,"modified":1554950050000,"deprecated":false,"name":"Exostosin-like 1","accession":"Q92935","gene":"EXTL1","description":"Probable glycosyltransferase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2838380843140211,"antibodyCount":98,"monoclonalCount":4,"pubmedCount":null,"jensenScore":19.856299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.473308748497377,"pubTatorScore":0.9746651654585328,"self":"https://pharos.nih.gov/idg/api/v1/targets(12142)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12142)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(12142)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12142)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12142)/publications"},"_namespace":null},{"id":12143,"version":2,"created":1554950051000,"modified":1554950057000,"deprecated":false,"name":"Bcl2-associated agonist of cell death","accession":"Q92934","gene":"BAD","description":"Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.088930324811283,"antibodyCount":2565,"monoclonalCount":226,"pubmedCount":null,"jensenScore":103.406296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.39019868467184,"pubTatorScore":3.4639309354127854,"self":"https://pharos.nih.gov/idg/api/v1/targets(12143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(12143)/properties"},"_links":{"count":1192,"href":"https://pharos.nih.gov/idg/api/v1/targets(12143)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12143)/synonyms"},"_publications":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(12143)/publications"},"_namespace":null},{"id":12144,"version":3,"created":1554950059000,"modified":1555040504000,"deprecated":false,"name":"GDNF family receptor alpha-1","accession":"P56159","gene":"GFRA1","description":"Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2317660471966048,"antibodyCount":318,"monoclonalCount":90,"pubmedCount":null,"jensenScore":141.368298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.333539261273785,"pubTatorScore":1.9650026751540899,"self":"https://pharos.nih.gov/idg/api/v1/targets(12144)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(12144)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(12144)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12144)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12144)/publications"},"_namespace":null},{"id":12145,"version":2,"created":1554950064000,"modified":1554950066000,"deprecated":false,"name":"RING finger protein 121","accession":"Q9H920","gene":"RNF121","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.39064077101627437,"antibodyCount":78,"monoclonalCount":7,"pubmedCount":null,"jensenScore":3.372066,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.96653366115666,"pubTatorScore":0.049463794812240475,"self":"https://pharos.nih.gov/idg/api/v1/targets(12145)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12145)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(12145)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12145)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12145)/publications"},"_namespace":null},{"id":12146,"version":3,"created":1554950066000,"modified":1555040507000,"deprecated":false,"name":"Phospholipid phosphatase 4","accession":"Q5VZY2","gene":"PLPP4","description":"Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4097111674601017,"antibodyCount":73,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.392099,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":0.18406025189705846,"self":"https://pharos.nih.gov/idg/api/v1/targets(12146)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(12146)/properties"},"_links":{"count":759,"href":"https://pharos.nih.gov/idg/api/v1/targets(12146)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12146)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12146)/publications"},"_namespace":null},{"id":12147,"version":2,"created":1554950070000,"modified":1554950073000,"deprecated":false,"name":"Krueppel-like factor 11","accession":"O14901","gene":"KLF11","description":"Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5824256825977825,"antibodyCount":237,"monoclonalCount":83,"pubmedCount":null,"jensenScore":49.938896,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.96822968085616,"pubTatorScore":1.650313294255163,"self":"https://pharos.nih.gov/idg/api/v1/targets(12147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12147)/publications"},"_namespace":null},{"id":12148,"version":3,"created":1554950074000,"modified":1555040507000,"deprecated":false,"name":"Protein Wnt-9a","accession":"O14904","gene":"WNT9A","description":"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4115969599511133,"antibodyCount":141,"monoclonalCount":25,"pubmedCount":null,"jensenScore":26.632059,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.725550214633916,"pubTatorScore":1.1970900334017145,"self":"https://pharos.nih.gov/idg/api/v1/targets(12148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(12148)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(12148)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12148)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12148)/publications"},"_namespace":null},{"id":12149,"version":2,"created":1554950078000,"modified":1554950081000,"deprecated":false,"name":"WD repeat-containing protein 43","accession":"Q15061","gene":"WDR43","description":"Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7432981736358266,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.444915,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.56188883043133,"pubTatorScore":0.8278715878322886,"self":"https://pharos.nih.gov/idg/api/v1/targets(12149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(12149)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(12149)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12149)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12149)/publications"},"_namespace":null},{"id":12150,"version":3,"created":1554950082000,"modified":1555040508000,"deprecated":false,"name":"Protein Wnt-9b","accession":"O14905","gene":"WNT9B","description":"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4475869612290377,"antibodyCount":98,"monoclonalCount":10,"pubmedCount":null,"jensenScore":27.303835,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":25.257813041123626,"pubTatorScore":1.2577777554432035,"self":"https://pharos.nih.gov/idg/api/v1/targets(12150)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(12150)/properties"},"_links":{"count":711,"href":"https://pharos.nih.gov/idg/api/v1/targets(12150)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12150)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12150)/publications"},"_namespace":null},{"id":12151,"version":2,"created":1554950085000,"modified":1554950088000,"deprecated":false,"name":"PDZ domain-containing protein GIPC1","accession":"O14908","gene":"GIPC1","description":"May be involved in G protein-linked signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0969529017058086,"antibodyCount":204,"monoclonalCount":9,"pubmedCount":null,"jensenScore":127.761977,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.13630218434852,"pubTatorScore":1.9964879122688326,"self":"https://pharos.nih.gov/idg/api/v1/targets(12151)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(12151)/properties"},"_links":{"count":1227,"href":"https://pharos.nih.gov/idg/api/v1/targets(12151)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12151)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12151)/publications"},"_namespace":null},{"id":12152,"version":3,"created":1554950089000,"modified":1555040512000,"deprecated":false,"name":"Tax1-binding protein 3","accession":"O14907","gene":"TAX1BP3","description":"May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7242338536421542,"antibodyCount":74,"monoclonalCount":16,"pubmedCount":null,"jensenScore":52.757039,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":32.36391899803486,"pubTatorScore":1.610981060510687,"self":"https://pharos.nih.gov/idg/api/v1/targets(12152)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(12152)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(12152)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12152)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12152)/publications"},"_namespace":null},{"id":12153,"version":2,"created":1554950093000,"modified":1554950098000,"deprecated":false,"name":"Periostin","accession":"Q15063","gene":"POSTN","description":"Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.843226793561282,"antibodyCount":396,"monoclonalCount":82,"pubmedCount":null,"jensenScore":747.548645,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.865610981773365,"pubTatorScore":2.1669871927601965,"self":"https://pharos.nih.gov/idg/api/v1/targets(12153)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":625,"href":"https://pharos.nih.gov/idg/api/v1/targets(12153)/properties"},"_links":{"count":1355,"href":"https://pharos.nih.gov/idg/api/v1/targets(12153)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12153)/synonyms"},"_publications":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12153)/publications"},"_namespace":null},{"id":12154,"version":3,"created":1554950100000,"modified":1555040513000,"deprecated":false,"name":"Exostosin-1","accession":"Q16394","gene":"EXT1","description":"Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.6880385746057867,"antibodyCount":178,"monoclonalCount":11,"pubmedCount":null,"jensenScore":491.17109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":49.43952284726095,"pubTatorScore":2.2837802807384624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12154)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(12154)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(12154)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12154)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12154)/publications"},"_namespace":null},{"id":12155,"version":2,"created":1554950106000,"modified":1554950111000,"deprecated":false,"name":"Receptor-type tyrosine-protein phosphatase N2","accession":"Q92932","gene":"PTPRN2","description":"Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.461902793760069,"antibodyCount":307,"monoclonalCount":123,"pubmedCount":null,"jensenScore":287.431364,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.00394299544052,"pubTatorScore":1.7090702838173812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12155)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(12155)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(12155)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(12155)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12155)/publications"},"_namespace":null},{"id":12156,"version":3,"created":1554950112000,"modified":1555040515000,"deprecated":false,"name":"Ras-related protein Rab-8B","accession":"Q92930","gene":"RAB8B","description":"The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9171893623760083,"antibodyCount":179,"monoclonalCount":7,"pubmedCount":null,"jensenScore":6.856617,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":40.65500302860759,"pubTatorScore":0.38123208067574926,"self":"https://pharos.nih.gov/idg/api/v1/targets(12156)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12156)/publications"},"_namespace":null},{"id":12157,"version":2,"created":1554950118000,"modified":1554950123000,"deprecated":false,"name":"Peroxisomal acyl-coenzyme A oxidase 1","accession":"Q15067","gene":"ACOX1","description":"Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.101775203242319,"antibodyCount":292,"monoclonalCount":63,"pubmedCount":null,"jensenScore":116.116476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.278181248003804,"pubTatorScore":2.3886439525082386,"self":"https://pharos.nih.gov/idg/api/v1/targets(12157)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":485,"href":"https://pharos.nih.gov/idg/api/v1/targets(12157)/properties"},"_links":{"count":1260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12157)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(12157)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(12157)/publications"},"_namespace":null},{"id":12158,"version":2,"created":1554950125000,"modified":1554950127000,"deprecated":false,"name":"Ventral anterior homeobox 1","accession":"Q5SQQ9","gene":"VAX1","description":"Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3246346176042196,"antibodyCount":90,"monoclonalCount":14,"pubmedCount":null,"jensenScore":21.45628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.94069530079446,"pubTatorScore":1.0343243440361596,"self":"https://pharos.nih.gov/idg/api/v1/targets(12158)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(12158)/properties"},"_links":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(12158)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12158)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12158)/publications"},"_namespace":null},{"id":12159,"version":2,"created":1554950127000,"modified":1554950131000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2","accession":"Q92925","gene":"SMARCD2","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9445236193642045,"antibodyCount":94,"monoclonalCount":38,"pubmedCount":null,"jensenScore":9.878547,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.37844411101189,"pubTatorScore":0.5651114905258079,"self":"https://pharos.nih.gov/idg/api/v1/targets(12159)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(12159)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(12159)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12159)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12159)/publications"},"_namespace":null},{"id":12160,"version":2,"created":1554950132000,"modified":1554950134000,"deprecated":false,"name":"CKLF-like MARVEL transmembrane domain-containing protein 2","accession":"Q8TAZ6","gene":"CMTM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8894847994787262,"antibodyCount":98,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.981968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.346561953270093,"pubTatorScore":0.8015927550579489,"self":"https://pharos.nih.gov/idg/api/v1/targets(12160)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(12160)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(12160)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12160)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12160)/publications"},"_namespace":null},{"id":12161,"version":3,"created":1554950134000,"modified":1555040517000,"deprecated":false,"name":"Jupiter microtubule associated homolog 2","accession":"Q9H910","gene":"JPT2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":56,"monoclonalCount":6,"pubmedCount":null,"jensenScore":0.571429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(12161)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12161)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(12161)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12161)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12161)/publications"},"_namespace":null},{"id":12162,"version":2,"created":1554950139000,"modified":1554950143000,"deprecated":false,"name":"Polyprenol reductase","accession":"Q9H8P0","gene":"SRD5A3","description":"Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3881616032779749,"antibodyCount":72,"monoclonalCount":2,"pubmedCount":null,"jensenScore":25.466518,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.16605528127247,"pubTatorScore":1.278626539802799,"self":"https://pharos.nih.gov/idg/api/v1/targets(12162)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(12162)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(12162)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12162)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12162)/publications"},"_namespace":null},{"id":12163,"version":2,"created":1554950143000,"modified":1554950144000,"deprecated":false,"name":"Putative Ras-related protein Rab-1C","accession":"Q92928","gene":"RAB1C","description":"Protein transport. Probably involved in vesicular traffic (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.3533917231782988,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":37.312299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.668962163279035,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12163)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12163)/properties"},"_links":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12163)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12163)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12163)/publications"},"_namespace":null},{"id":12164,"version":2,"created":1554950144000,"modified":1554950148000,"deprecated":false,"name":"Ras-interacting protein 1","accession":"Q5U651","gene":"RASIP1","description":"Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3294947612877615,"antibodyCount":77,"monoclonalCount":3,"pubmedCount":null,"jensenScore":18.728051,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.79073274522037,"pubTatorScore":2.0312569357049535,"self":"https://pharos.nih.gov/idg/api/v1/targets(12164)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12164)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(12164)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12164)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12164)/publications"},"_namespace":null},{"id":12165,"version":2,"created":1554950149000,"modified":1554950149000,"deprecated":false,"name":"Cyclin-Y-like protein 2","accession":"Q5T2Q4","gene":"CCNYL2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.8405910166146673,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12165)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12165)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12165)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12165)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12165)/publications"},"_namespace":null},{"id":12166,"version":2,"created":1554950149000,"modified":1554950151000,"deprecated":false,"name":"C2 calcium-dependent domain-containing protein 6","accession":"Q53TS8","gene":"C2CD6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":101,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.090909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12166)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(12166)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(12166)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12166)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12166)/publications"},"_namespace":null},{"id":12167,"version":2,"created":1554950152000,"modified":1554950157000,"deprecated":false,"name":"Protocadherin-17","accession":"O14917","gene":"PCDH17","description":"Potential calcium-dependent cell-adhesion protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2728505980189524,"antibodyCount":120,"monoclonalCount":2,"pubmedCount":null,"jensenScore":21.593172,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.61055706495642,"pubTatorScore":1.3025837028281044,"self":"https://pharos.nih.gov/idg/api/v1/targets(12167)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(12167)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(12167)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12167)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12167)/publications"},"_namespace":null},{"id":12168,"version":2,"created":1554950157000,"modified":1554950162000,"deprecated":false,"name":"Zinc finger protein OZF","accession":"Q15072","gene":"ZNF146","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1823535300481716,"antibodyCount":121,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.923986,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.56042886329476,"pubTatorScore":1.1643882523168216,"self":"https://pharos.nih.gov/idg/api/v1/targets(12168)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12168)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(12168)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12168)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12168)/publications"},"_namespace":null},{"id":12169,"version":2,"created":1554950162000,"modified":1554950166000,"deprecated":false,"name":"Mitochondrial inner membrane protein OXA1L","accession":"Q15070","gene":"OXA1L","description":"Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.943396211447951,"antibodyCount":141,"monoclonalCount":8,"pubmedCount":null,"jensenScore":837.977616,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.60441822214045,"pubTatorScore":2.623949566168505,"self":"https://pharos.nih.gov/idg/api/v1/targets(12169)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12169)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12169)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12169)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12169)/publications"},"_namespace":null},{"id":12170,"version":2,"created":1554950167000,"modified":1554950177000,"deprecated":false,"name":"P2Y purinoceptor 6","accession":"Q15077","gene":"P2RY6","description":"Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.9987267795754486,"antibodyCount":191,"monoclonalCount":6,"pubmedCount":null,"jensenScore":102.567967,"patentCount":3032,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.625876005972266,"pubTatorScore":2.2083896787706405,"self":"https://pharos.nih.gov/idg/api/v1/targets(12170)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(12170)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(12170)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12170)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12170)/publications"},"_namespace":null},{"id":12171,"version":2,"created":1554950178000,"modified":1554950183000,"deprecated":false,"name":"Early endosome antigen 1","accession":"Q15075","gene":"EEA1","description":"Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.320118965504558,"antibodyCount":314,"monoclonalCount":96,"pubmedCount":null,"jensenScore":167.589472,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.20345852988134,"pubTatorScore":2.177212242285194,"self":"https://pharos.nih.gov/idg/api/v1/targets(12171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(12171)/properties"},"_links":{"count":1144,"href":"https://pharos.nih.gov/idg/api/v1/targets(12171)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12171)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12171)/publications"},"_namespace":null},{"id":12172,"version":2,"created":1554950184000,"modified":1554950188000,"deprecated":false,"name":"SWI/SNF complex subunit SMARCC1","accession":"Q92922","gene":"SMARCC1","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-1.8214595797865027,"antibodyCount":148,"monoclonalCount":21,"pubmedCount":null,"jensenScore":65.947589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.409431609766074,"pubTatorScore":1.484514854435137,"self":"https://pharos.nih.gov/idg/api/v1/targets(12172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(12172)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12172)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12172)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12172)/publications"},"_namespace":null},{"id":12173,"version":3,"created":1554950189000,"modified":1555040519000,"deprecated":false,"name":"Cyclin-dependent kinase 5 activator 1","accession":"Q15078","gene":"CDK5R1","description":"p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.779140134739342,"antibodyCount":217,"monoclonalCount":32,"pubmedCount":null,"jensenScore":52.412316,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":42.367038642585754,"pubTatorScore":2.314794290077728,"self":"https://pharos.nih.gov/idg/api/v1/targets(12173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(12173)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(12173)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12173)/synonyms"},"_publications":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12173)/publications"},"_namespace":null},{"id":12174,"version":3,"created":1554950197000,"modified":1555040521000,"deprecated":false,"name":"Protein lin-7 homolog A","accession":"O14910","gene":"LIN7A","description":"Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.788357604067082,"antibodyCount":116,"monoclonalCount":22,"pubmedCount":null,"jensenScore":53.458105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.37672997498169,"pubTatorScore":1.4019993851707866,"self":"https://pharos.nih.gov/idg/api/v1/targets(12174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(12174)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(12174)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12174)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12174)/publications"},"_namespace":null},{"id":12175,"version":2,"created":1554950203000,"modified":1554950207000,"deprecated":false,"name":"Fibroblast growth factor 14","accession":"Q92915","gene":"FGF14","description":"Probably involved in nervous system development and function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6465923778101075,"antibodyCount":116,"monoclonalCount":8,"pubmedCount":null,"jensenScore":46.119595,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.80516905468977,"pubTatorScore":1.4342551087336877,"self":"https://pharos.nih.gov/idg/api/v1/targets(12175)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(12175)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(12175)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12175)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12175)/publications"},"_namespace":null},{"id":12176,"version":3,"created":1554950208000,"modified":1555040522000,"deprecated":false,"name":"Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2","accession":"Q9H903","gene":"MTHFD2L","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.45229766665168547,"antibodyCount":114,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.7,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.999451793796936,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(12176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(12176)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(12176)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12176)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12176)/publications"},"_namespace":null},{"id":12177,"version":2,"created":1554950212000,"modified":1554950214000,"deprecated":false,"name":"Fibroblast growth factor 11","accession":"Q92914","gene":"FGF11","description":"Probably involved in nervous system development and function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.030567452435646,"antibodyCount":139,"monoclonalCount":22,"pubmedCount":null,"jensenScore":9.358814,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.091119352785242,"pubTatorScore":0.6957201227471774,"self":"https://pharos.nih.gov/idg/api/v1/targets(12177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(12177)/properties"},"_links":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(12177)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12177)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12177)/publications"},"_namespace":null},{"id":12178,"version":2,"created":1554950214000,"modified":1554950219000,"deprecated":false,"name":"Fibroblast growth factor 13","accession":"Q92913","gene":"FGF13","description":"May also play a role in MAPK signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.946740958314051,"antibodyCount":368,"monoclonalCount":150,"pubmedCount":null,"jensenScore":831.909385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.688998126167846,"pubTatorScore":1.2824632276410928,"self":"https://pharos.nih.gov/idg/api/v1/targets(12178)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(12178)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(12178)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(12178)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12178)/publications"},"_namespace":null},{"id":12179,"version":3,"created":1554950220000,"modified":1555040523000,"deprecated":false,"name":"Protein zwilch homolog","accession":"Q9H900","gene":"ZWILCH","description":"Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0712096720837432,"antibodyCount":112,"monoclonalCount":10,"pubmedCount":null,"jensenScore":9.323642,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.38028101846722,"pubTatorScore":0.5201297957152787,"self":"https://pharos.nih.gov/idg/api/v1/targets(12179)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(12179)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(12179)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12179)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12179)/publications"},"_namespace":null},{"id":12180,"version":2,"created":1554950225000,"modified":1554950234000,"deprecated":false,"name":"Mitogen-activated protein kinase kinase kinase kinase 1","accession":"Q92918","gene":"MAP4K1","description":"Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.3473996936842585,"antibodyCount":456,"monoclonalCount":38,"pubmedCount":null,"jensenScore":32.282139,"patentCount":4503,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.09847206158899,"pubTatorScore":1.5826772849421222,"self":"https://pharos.nih.gov/idg/api/v1/targets(12180)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(12180)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(12180)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12180)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(12180)/publications"},"_namespace":null},{"id":12181,"version":3,"created":1554950235000,"modified":1555040525000,"deprecated":false,"name":"Homeobox protein DLX-6","accession":"P56179","gene":"DLX6","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5299083634984465,"antibodyCount":107,"monoclonalCount":8,"pubmedCount":null,"jensenScore":27.86695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":27.33266473001516,"pubTatorScore":1.2533114185164154,"self":"https://pharos.nih.gov/idg/api/v1/targets(12181)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12181)/properties"},"_links":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(12181)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12181)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12181)/publications"},"_namespace":null},{"id":12182,"version":2,"created":1554950240000,"modified":1554950242000,"deprecated":false,"name":"Protein FAM110D","accession":"Q8TAY7","gene":"FAM110D","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.284365345558587,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12182)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(12182)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12182)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12182)/publications"},"_namespace":null},{"id":12183,"version":2,"created":1554950242000,"modified":1554950244000,"deprecated":false,"name":"ATPase family AAA domain-containing protein 3C","accession":"Q5T2N8","gene":"ATAD3C","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.24303804977203064,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.060256,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.960953915908654,"pubTatorScore":0.06694654146226692,"self":"https://pharos.nih.gov/idg/api/v1/targets(12183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(12183)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(12183)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12183)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12183)/publications"},"_namespace":null},{"id":12184,"version":3,"created":1554950245000,"modified":1555040526000,"deprecated":false,"name":"G-patch domain and KOW motifs-containing protein","accession":"Q92917","gene":"GPKOW","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9815165780199441,"antibodyCount":136,"monoclonalCount":3,"pubmedCount":null,"jensenScore":8.995635,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.464042033064228,"pubTatorScore":0.6797306160859238,"self":"https://pharos.nih.gov/idg/api/v1/targets(12184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(12184)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(12184)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12184)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12184)/publications"},"_namespace":null},{"id":12185,"version":3,"created":1554950249000,"modified":1555040528000,"deprecated":false,"name":"Receptor expression-enhancing protein 1","accession":"Q9H902","gene":"REEP1","description":"Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4515003943894937,"antibodyCount":100,"monoclonalCount":39,"pubmedCount":null,"jensenScore":28.170851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":33.89345078446519,"pubTatorScore":1.5469753481640174,"self":"https://pharos.nih.gov/idg/api/v1/targets(12185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12185)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(12185)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12185)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12185)/publications"},"_namespace":null},{"id":12186,"version":2,"created":1554950254000,"modified":1554950257000,"deprecated":false,"name":"Homeobox protein DLX-5","accession":"P56178","gene":"DLX5","description":"Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1945514778198194,"antibodyCount":405,"monoclonalCount":152,"pubmedCount":null,"jensenScore":150.93371,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.938573977986614,"pubTatorScore":1.8185730386155774,"self":"https://pharos.nih.gov/idg/api/v1/targets(12186)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(12186)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(12186)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12186)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12186)/publications"},"_namespace":null},{"id":12187,"version":2,"created":1554950258000,"modified":1554950261000,"deprecated":false,"name":"Homeobox protein DLX-1","accession":"P56177","gene":"DLX1","description":"Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6434083980780874,"antibodyCount":241,"monoclonalCount":119,"pubmedCount":null,"jensenScore":42.260267,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.432661056367834,"pubTatorScore":1.2189663825029315,"self":"https://pharos.nih.gov/idg/api/v1/targets(12187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12187)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(12187)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12187)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12187)/publications"},"_namespace":null},{"id":12188,"version":2,"created":1554950262000,"modified":1554950265000,"deprecated":false,"name":"Single-minded homolog 1","accession":"P81133","gene":"SIM1","description":"Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.922574313770957,"antibodyCount":132,"monoclonalCount":2,"pubmedCount":null,"jensenScore":84.665398,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.84178892639812,"pubTatorScore":1.696750954291133,"self":"https://pharos.nih.gov/idg/api/v1/targets(12188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12188)/properties"},"_links":{"count":605,"href":"https://pharos.nih.gov/idg/api/v1/targets(12188)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12188)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12188)/publications"},"_namespace":null},{"id":12189,"version":2,"created":1554950266000,"modified":1554950269000,"deprecated":false,"name":"Activating transcription factor 7-interacting protein 2","accession":"Q5U623","gene":"ATF7IP2","description":"Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0699732424770916,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.797258,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.774422449715125,"pubTatorScore":-0.13305669238436846,"self":"https://pharos.nih.gov/idg/api/v1/targets(12189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12189)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(12189)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12189)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12189)/publications"},"_namespace":null},{"id":12190,"version":2,"created":1554950270000,"modified":1554950273000,"deprecated":false,"name":"RNA-binding E3 ubiquitin-protein ligase MEX3C","accession":"Q5U5Q3","gene":"MEX3C","description":"E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.713846766454782,"antibodyCount":111,"monoclonalCount":1,"pubmedCount":null,"jensenScore":7.910515,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.09246123585044,"pubTatorScore":0.7558747794804703,"self":"https://pharos.nih.gov/idg/api/v1/targets(12190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(12190)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(12190)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12190)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12190)/publications"},"_namespace":null},{"id":12191,"version":2,"created":1554950274000,"modified":1554950277000,"deprecated":false,"name":"Synaptosomal-associated protein 47","accession":"Q5SQN1","gene":"SNAP47","description":"Plays a role in intracellular membrane fusion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.2023184490722707,"antibodyCount":34,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.163738,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.151700354132135,"pubTatorScore":0.9890046156985368,"self":"https://pharos.nih.gov/idg/api/v1/targets(12191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(12191)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(12191)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12191)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12191)/publications"},"_namespace":null},{"id":12192,"version":2,"created":1554950278000,"modified":1554950282000,"deprecated":false,"name":"Regulator of G-protein signaling 12","accession":"O14924","gene":"RGS12","description":"Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.393561879319271,"antibodyCount":69,"monoclonalCount":2,"pubmedCount":null,"jensenScore":26.720447,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.976525244438655,"pubTatorScore":1.15965293086194,"self":"https://pharos.nih.gov/idg/api/v1/targets(12192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(12192)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(12192)/links"},"_synonyms":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(12192)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12192)/publications"},"_namespace":null},{"id":12193,"version":2,"created":1554950283000,"modified":1554950287000,"deprecated":false,"name":"Neutrophil cytosol factor 4","accession":"Q15080","gene":"NCF4","description":"Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.457075032705316,"antibodyCount":346,"monoclonalCount":41,"pubmedCount":null,"jensenScore":273.944529,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.270315093139594,"pubTatorScore":2.10493937167343,"self":"https://pharos.nih.gov/idg/api/v1/targets(12193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(12193)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(12193)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(12193)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12193)/publications"},"_namespace":null},{"id":12194,"version":3,"created":1554950289000,"modified":1555040529000,"deprecated":false,"name":"Fascin-2","accession":"O14926","gene":"FSCN2","description":"Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2954874359467323,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.209186993135948,"pubTatorScore":1.2388998194606027,"self":"https://pharos.nih.gov/idg/api/v1/targets(12194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(12194)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(12194)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12194)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12194)/publications"},"_namespace":null},{"id":12195,"version":3,"created":1554950292000,"modified":1555040530000,"deprecated":false,"name":"Mitochondrial import inner membrane translocase subunit Tim23","accession":"O14925","gene":"TIMM23","description":"Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7740919341204614,"antibodyCount":49,"monoclonalCount":3,"pubmedCount":null,"jensenScore":8.833141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":36.765983562792,"pubTatorScore":1.7402843593950474,"self":"https://pharos.nih.gov/idg/api/v1/targets(12195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(12195)/properties"},"_links":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(12195)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12195)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12195)/publications"},"_namespace":null},{"id":12196,"version":2,"created":1554950295000,"modified":1554950297000,"deprecated":false,"name":"Protein FAM209B","accession":"Q5JX69","gene":"FAM209B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.273666363936682,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(12196)/properties"},"_links":{"count":724,"href":"https://pharos.nih.gov/idg/api/v1/targets(12196)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12196)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12196)/publications"},"_namespace":null},{"id":12197,"version":3,"created":1554950297000,"modified":1555040531000,"deprecated":false,"name":"Protein disulfide-isomerase A6","accession":"Q15084","gene":"PDIA6","description":"May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6132824262196914,"antibodyCount":152,"monoclonalCount":14,"pubmedCount":null,"jensenScore":35.244255,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":43.40759571407966,"pubTatorScore":1.35959406889741,"self":"https://pharos.nih.gov/idg/api/v1/targets(12197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":474,"href":"https://pharos.nih.gov/idg/api/v1/targets(12197)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(12197)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12197)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12197)/publications"},"_namespace":null},{"id":12198,"version":3,"created":1554950302000,"modified":1555040532000,"deprecated":false,"name":"Histone acetyltransferase type B catalytic subunit","accession":"O14929","gene":"HAT1","description":"Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.3322219616298794,"antibodyCount":292,"monoclonalCount":5,"pubmedCount":null,"jensenScore":23.142531,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.43896022025909,"pubTatorScore":1.7024949692476559,"self":"https://pharos.nih.gov/idg/api/v1/targets(12198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(12198)/properties"},"_links":{"count":1082,"href":"https://pharos.nih.gov/idg/api/v1/targets(12198)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12198)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12198)/publications"},"_namespace":null},{"id":12199,"version":2,"created":1554950307000,"modified":1554950311000,"deprecated":false,"name":"Rho GTPase-activating protein 32","accession":"A7KAX9","gene":"ARHGAP32","description":"GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9526125811877566,"antibodyCount":60,"monoclonalCount":0,"pubmedCount":null,"jensenScore":85.734686,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.70392360020765,"pubTatorScore":1.4032090532952282,"self":"https://pharos.nih.gov/idg/api/v1/targets(12199)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(12199)/properties"},"_links":{"count":1093,"href":"https://pharos.nih.gov/idg/api/v1/targets(12199)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12199)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12199)/publications"},"_namespace":null},{"id":12200,"version":2,"created":1554950312000,"modified":1554950316000,"deprecated":false,"name":"Zinc finger protein 395","accession":"Q9H8N7","gene":"ZNF395","description":"Plays a role in papillomavirus genes transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0606978490395014,"antibodyCount":188,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.760275,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.79761228544332,"pubTatorScore":1.5797836080456122,"self":"https://pharos.nih.gov/idg/api/v1/targets(12200)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(12200)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(12200)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12200)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12200)/publications"},"_namespace":null},{"id":12201,"version":4,"created":1554950317000,"modified":1555040534000,"deprecated":false,"name":"Inhibitor of nuclear factor kappa-B kinase subunit beta","accession":"O14920","gene":"IKBKB","description":"Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.9312465857118006,"antibodyCount":1824,"monoclonalCount":285,"pubmedCount":null,"jensenScore":790.140149,"patentCount":29687,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":62.60718470762219,"pubTatorScore":2.6917300735101852,"self":"https://pharos.nih.gov/idg/api/v1/targets(12201)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(12201)/properties"},"_links":{"count":1602,"href":"https://pharos.nih.gov/idg/api/v1/targets(12201)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(12201)/synonyms"},"_publications":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(12201)/publications"},"_namespace":null},{"id":12202,"version":3,"created":1554950391000,"modified":1555040540000,"deprecated":false,"name":"Sodium/iodide cotransporter","accession":"Q92911","gene":"SLC5A5","description":"Mediates iodide uptake in the thyroid gland.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-3.0341353650954286,"antibodyCount":360,"monoclonalCount":276,"pubmedCount":null,"jensenScore":1016.447364,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":30.424677412838275,"pubTatorScore":2.616865862101365,"self":"https://pharos.nih.gov/idg/api/v1/targets(12202)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(12202)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(12202)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12202)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12202)/publications"},"_namespace":null},{"id":12203,"version":2,"created":1554950398000,"modified":1554950400000,"deprecated":false,"name":"Ribosomal RNA processing protein 1 homolog A","accession":"P56182","gene":"RRP1","description":"Plays a critical role in the generation of 28S rRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7104360847655019,"antibodyCount":142,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.284928,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.90456675303628,"pubTatorScore":1.1043732306519038,"self":"https://pharos.nih.gov/idg/api/v1/targets(12203)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(12203)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(12203)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12203)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12203)/publications"},"_namespace":null},{"id":12204,"version":3,"created":1554950401000,"modified":1555040545000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial","accession":"P56181","gene":"NDUFV3","description":"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.6628702086250431,"antibodyCount":106,"monoclonalCount":1,"pubmedCount":null,"jensenScore":4.680953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":37.61965333029157,"pubTatorScore":0.43136376415898736,"self":"https://pharos.nih.gov/idg/api/v1/targets(12204)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(12204)/properties"},"_links":{"count":1116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12204)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12204)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12204)/publications"},"_namespace":null},{"id":12205,"version":3,"created":1554950408000,"modified":1555040548000,"deprecated":false,"name":"Regulator of G-protein signaling 13","accession":"O14921","gene":"RGS13","description":"Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7507145966980641,"antibodyCount":181,"monoclonalCount":17,"pubmedCount":null,"jensenScore":6.62717,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":24.557601261240375,"pubTatorScore":0.6860721244338018,"self":"https://pharos.nih.gov/idg/api/v1/targets(12205)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(12205)/properties"},"_links":{"count":644,"href":"https://pharos.nih.gov/idg/api/v1/targets(12205)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12205)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12205)/publications"},"_namespace":null},{"id":12206,"version":2,"created":1554950411000,"modified":1554950412000,"deprecated":false,"name":"Putative tyrosine-protein phosphatase TPTE","accession":"P56180","gene":"TPTE","description":"Could be involved in signal transduction.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1187477633099943,"antibodyCount":234,"monoclonalCount":9,"pubmedCount":null,"jensenScore":127.555963,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.78622115140969,"pubTatorScore":1.5652312376965516,"self":"https://pharos.nih.gov/idg/api/v1/targets(12206)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12206)/properties"},"_links":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12206)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12206)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12206)/publications"},"_namespace":null},{"id":12207,"version":2,"created":1554950412000,"modified":1554950414000,"deprecated":false,"name":"Deleted in azoospermia-like","accession":"Q92904","gene":"DAZL","description":"RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1762135301628027,"antibodyCount":191,"monoclonalCount":28,"pubmedCount":null,"jensenScore":156.17007,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.50355605353774,"pubTatorScore":2.0770409274735653,"self":"https://pharos.nih.gov/idg/api/v1/targets(12207)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(12207)/properties"},"_links":{"count":544,"href":"https://pharos.nih.gov/idg/api/v1/targets(12207)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12207)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12207)/publications"},"_namespace":null},{"id":12208,"version":3,"created":1554950415000,"modified":1555040550000,"deprecated":false,"name":"Phosphatidate cytidylyltransferase 1","accession":"Q92903","gene":"CDS1","description":"Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1596751189195504,"antibodyCount":60,"monoclonalCount":9,"pubmedCount":null,"jensenScore":14.904304,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":36.55409922615836,"pubTatorScore":2.305859123955595,"self":"https://pharos.nih.gov/idg/api/v1/targets(12208)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(12208)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(12208)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12208)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12208)/publications"},"_namespace":null},{"id":12209,"version":2,"created":1554950420000,"modified":1554950424000,"deprecated":false,"name":"Gasdermin-B","accession":"Q8TAX9","gene":"GSDMB","description":"The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5173573395771756,"antibodyCount":133,"monoclonalCount":22,"pubmedCount":null,"jensenScore":35.001954,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.990243113866118,"pubTatorScore":1.481402809182813,"self":"https://pharos.nih.gov/idg/api/v1/targets(12209)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(12209)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(12209)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12209)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12209)/publications"},"_namespace":null},{"id":12210,"version":2,"created":1554950425000,"modified":1554950428000,"deprecated":false,"name":"Probable E3 ubiquitin-protein ligase HECTD2","accession":"Q5U5R9","gene":"HECTD2","description":"Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":136,"monoclonalCount":12,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.341304841818324,"pubTatorScore":0.6842468074179955,"self":"https://pharos.nih.gov/idg/api/v1/targets(12210)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12210)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(12210)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12210)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12210)/publications"},"_namespace":null},{"id":12211,"version":3,"created":1554950429000,"modified":1555040551000,"deprecated":false,"name":"Hermansky-Pudlak syndrome 1 protein","accession":"Q92902","gene":"HPS1","description":"Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.23408320494763177,"antibodyCount":70,"monoclonalCount":25,"pubmedCount":null,"jensenScore":0.916667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":41.54157572320051,"pubTatorScore":1.845376376995216,"self":"https://pharos.nih.gov/idg/api/v1/targets(12211)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(12211)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(12211)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12211)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12211)/publications"},"_namespace":null},{"id":12212,"version":2,"created":1554950433000,"modified":1554950436000,"deprecated":false,"name":"60S ribosomal protein L3-like","accession":"Q92901","gene":"RPL3L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.14175223401791776,"antibodyCount":47,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.840608,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.07376521493864,"pubTatorScore":0.2541745247522102,"self":"https://pharos.nih.gov/idg/api/v1/targets(12212)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(12212)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(12212)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12212)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12212)/publications"},"_namespace":null},{"id":12213,"version":2,"created":1554950437000,"modified":1554950442000,"deprecated":false,"name":"Transcription factor GATA-6","accession":"Q92908","gene":"GATA6","description":"Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.419093262795822,"antibodyCount":367,"monoclonalCount":69,"pubmedCount":null,"jensenScore":265.8074,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.148605775156526,"pubTatorScore":2.249901359841935,"self":"https://pharos.nih.gov/idg/api/v1/targets(12213)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(12213)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12213)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12213)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12213)/publications"},"_namespace":null},{"id":12214,"version":2,"created":1554950444000,"modified":1554950448000,"deprecated":false,"name":"T-cell immunomodulatory protein","accession":"Q8TB96","gene":"ITFG1","description":"Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4497008199023282,"antibodyCount":134,"monoclonalCount":22,"pubmedCount":null,"jensenScore":25.625732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.434552748023552,"pubTatorScore":0.7961069724438372,"self":"https://pharos.nih.gov/idg/api/v1/targets(12214)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(12214)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(12214)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12214)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12214)/publications"},"_namespace":null},{"id":12215,"version":2,"created":1554950449000,"modified":1554950451000,"deprecated":false,"name":"Mucin-7","accession":"Q8TAX7","gene":"MUC7","description":"May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9696431946891582,"antibodyCount":94,"monoclonalCount":49,"pubmedCount":null,"jensenScore":94.403255,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.44395186581938,"pubTatorScore":2.9546453444556997,"self":"https://pharos.nih.gov/idg/api/v1/targets(12215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(12215)/properties"},"_links":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(12215)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12215)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12215)/publications"},"_namespace":null},{"id":12216,"version":3,"created":1554950452000,"modified":1555040552000,"deprecated":false,"name":"COP9 signalosome complex subunit 5","accession":"Q92905","gene":"COPS5","description":"Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.269885824457712,"antibodyCount":374,"monoclonalCount":118,"pubmedCount":null,"jensenScore":213.634971,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":44.722905234563186,"pubTatorScore":2.1403029303083754,"self":"https://pharos.nih.gov/idg/api/v1/targets(12216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(12216)/properties"},"_links":{"count":1246,"href":"https://pharos.nih.gov/idg/api/v1/targets(12216)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12216)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(12216)/publications"},"_namespace":null},{"id":12217,"version":3,"created":1554950457000,"modified":1555040554000,"deprecated":false,"name":"Protein FAM209A","accession":"Q5JX71","gene":"FAM209A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":13.614747022004009,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12217)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(12217)/properties"},"_links":{"count":714,"href":"https://pharos.nih.gov/idg/api/v1/targets(12217)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(12217)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12217)/publications"},"_namespace":null},{"id":12218,"version":2,"created":1554950460000,"modified":1554950466000,"deprecated":false,"name":"Peripheral plasma membrane protein CASK","accession":"O14936","gene":"CASK","description":"Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.1224132882600104,"antibodyCount":227,"monoclonalCount":21,"pubmedCount":null,"jensenScore":130.236728,"patentCount":9697,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.971402214522946,"pubTatorScore":2.0529823307824167,"self":"https://pharos.nih.gov/idg/api/v1/targets(12218)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(12218)/properties"},"_links":{"count":1303,"href":"https://pharos.nih.gov/idg/api/v1/targets(12218)/links"},"_synonyms":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(12218)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12218)/publications"},"_namespace":null},{"id":12219,"version":2,"created":1554950467000,"modified":1554950496000,"deprecated":false,"name":"Phospholipase D2","accession":"O14939","gene":"PLD2","description":"May have a role in signal-induced cytoskeletal regulation and/or endocytosis.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.471970783387015,"antibodyCount":172,"monoclonalCount":13,"pubmedCount":null,"jensenScore":312.166734,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.69215443601487,"pubTatorScore":2.169984312185703,"self":"https://pharos.nih.gov/idg/api/v1/targets(12219)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":527,"href":"https://pharos.nih.gov/idg/api/v1/targets(12219)/properties"},"_links":{"count":1208,"href":"https://pharos.nih.gov/idg/api/v1/targets(12219)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12219)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(12219)/publications"},"_namespace":null},{"id":12220,"version":3,"created":1554950497000,"modified":1555040555000,"deprecated":false,"name":"Follistatin-related protein 4","accession":"Q6MZW2","gene":"FSTL4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":35,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.052632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.18123640625321,"pubTatorScore":-1.041393119452924,"self":"https://pharos.nih.gov/idg/api/v1/targets(12220)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12220)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(12220)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12220)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12220)/publications"},"_namespace":null},{"id":12221,"version":2,"created":1554950501000,"modified":1554950504000,"deprecated":false,"name":"Protein odd-skipped-related 1","accession":"Q8TAX0","gene":"OSR1","description":"Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0990143194943707,"antibodyCount":343,"monoclonalCount":188,"pubmedCount":null,"jensenScore":15.040857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.07312142027186,"pubTatorScore":1.644200854047401,"self":"https://pharos.nih.gov/idg/api/v1/targets(12221)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(12221)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(12221)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12221)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12221)/publications"},"_namespace":null},{"id":12222,"version":2,"created":1554950505000,"modified":1554950508000,"deprecated":false,"name":"Protein eva-1 homolog A","accession":"Q9H8M9","gene":"EVA1A","description":"Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5553827190299798,"antibodyCount":86,"monoclonalCount":2,"pubmedCount":null,"jensenScore":36.964742,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.523955818696102,"pubTatorScore":1.0330884955406423,"self":"https://pharos.nih.gov/idg/api/v1/targets(12222)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12222)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(12222)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12222)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12222)/publications"},"_namespace":null},{"id":12223,"version":3,"created":1554950509000,"modified":1555040556000,"deprecated":false,"name":"3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic","accession":"Q8TB92","gene":"HMGCLL1","description":"Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.14612803828400495,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.618056,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.90782264290732,"pubTatorScore":0.3679767232525211,"self":"https://pharos.nih.gov/idg/api/v1/targets(12223)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(12223)/properties"},"_links":{"count":861,"href":"https://pharos.nih.gov/idg/api/v1/targets(12223)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12223)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12223)/publications"},"_namespace":null},{"id":12224,"version":2,"created":1554950514000,"modified":1554950517000,"deprecated":false,"name":"Acyl-CoA dehydrogenase family member 10","accession":"Q6JQN1","gene":"ACAD10","description":"Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7663597323236081,"antibodyCount":129,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.435716,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.00262523976593,"pubTatorScore":0.6678975735209101,"self":"https://pharos.nih.gov/idg/api/v1/targets(12224)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12224)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(12224)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12224)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12224)/publications"},"_namespace":null},{"id":12225,"version":2,"created":1554950517000,"modified":1554950522000,"deprecated":false,"name":"Regulator of nonsense transcripts 1","accession":"Q92900","gene":"UPF1","description":"RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3562957030266056,"antibodyCount":239,"monoclonalCount":17,"pubmedCount":null,"jensenScore":226.847413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.010948570752795,"pubTatorScore":2.1480773467679204,"self":"https://pharos.nih.gov/idg/api/v1/targets(12225)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":538,"href":"https://pharos.nih.gov/idg/api/v1/targets(12225)/properties"},"_links":{"count":1203,"href":"https://pharos.nih.gov/idg/api/v1/targets(12225)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12225)/synonyms"},"_publications":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12225)/publications"},"_namespace":null},{"id":12226,"version":2,"created":1554950523000,"modified":1554950525000,"deprecated":false,"name":"Natural cytotoxicity triggering receptor 3","accession":"O14931","gene":"NCR3","description":"Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.596994504847223,"antibodyCount":247,"monoclonalCount":111,"pubmedCount":null,"jensenScore":374.668065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.084461802977007,"pubTatorScore":2.252675275967952,"self":"https://pharos.nih.gov/idg/api/v1/targets(12226)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(12226)/properties"},"_links":{"count":739,"href":"https://pharos.nih.gov/idg/api/v1/targets(12226)/links"},"_synonyms":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(12226)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12226)/publications"},"_namespace":null},{"id":12227,"version":2,"created":1554950526000,"modified":1554950531000,"deprecated":false,"name":"Metal transporter CNNM2","accession":"Q9H8M5","gene":"CNNM2","description":"Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1979813035782825,"antibodyCount":115,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.406633,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.26559508245425,"pubTatorScore":1.2856019512858938,"self":"https://pharos.nih.gov/idg/api/v1/targets(12227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(12227)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(12227)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12227)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12227)/publications"},"_namespace":null},{"id":12228,"version":3,"created":1554950532000,"modified":1555040557000,"deprecated":false,"name":"Ubiquitin/ISG15-conjugating enzyme E2 L6","accession":"O14933","gene":"UBE2L6","description":"Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2350079963680967,"antibodyCount":235,"monoclonalCount":66,"pubmedCount":null,"jensenScore":13.918932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.94196071625318,"pubTatorScore":1.337864214275862,"self":"https://pharos.nih.gov/idg/api/v1/targets(12228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(12228)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(12228)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12228)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12228)/publications"},"_namespace":null},{"id":12229,"version":2,"created":1554950536000,"modified":1554950551000,"deprecated":false,"name":"Methionine--tRNA ligase, cytoplasmic","accession":"P56192","gene":"MARS","description":"Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.7515193717628301,"antibodyCount":88,"monoclonalCount":31,"pubmedCount":null,"jensenScore":50.28985,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.6158425083886,"pubTatorScore":2.0847251814547687,"self":"https://pharos.nih.gov/idg/api/v1/targets(12229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(12229)/properties"},"_links":{"count":1199,"href":"https://pharos.nih.gov/idg/api/v1/targets(12229)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(12229)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12229)/publications"},"_namespace":null},{"id":12230,"version":2,"created":1554950552000,"modified":1554950560000,"deprecated":false,"name":"Neuropeptide S receptor","accession":"Q6W5P4","gene":"NPSR1","description":"G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.136412479381644,"antibodyCount":141,"monoclonalCount":21,"pubmedCount":null,"jensenScore":165.611015,"patentCount":6027,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.002557319714903,"pubTatorScore":2.055123410583391,"self":"https://pharos.nih.gov/idg/api/v1/targets(12230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(12230)/properties"},"_links":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(12230)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12230)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12230)/publications"},"_namespace":null},{"id":12231,"version":3,"created":1554950560000,"modified":1555040559000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase MINDY-3","accession":"Q9H8M7","gene":"MINDY3","description":"Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4966331991044546,"antibodyCount":36,"monoclonalCount":3,"pubmedCount":null,"jensenScore":27.737562,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":0.0,"pubTatorScore":0.6103325090997167,"self":"https://pharos.nih.gov/idg/api/v1/targets(12231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(12231)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(12231)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12231)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12231)/publications"},"_namespace":null},{"id":12232,"version":2,"created":1554950564000,"modified":1554950569000,"deprecated":false,"name":"Cancer-associated gene 1 protein","accession":"Q8TC20","gene":"CAGE1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.770377023033241,"antibodyCount":109,"monoclonalCount":6,"pubmedCount":null,"jensenScore":551.717487,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.934583860852946,"pubTatorScore":2.314747504807794,"self":"https://pharos.nih.gov/idg/api/v1/targets(12232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(12232)/properties"},"_links":{"count":604,"href":"https://pharos.nih.gov/idg/api/v1/targets(12232)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12232)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12232)/publications"},"_namespace":null},{"id":12233,"version":2,"created":1554950570000,"modified":1554950572000,"deprecated":false,"name":"Zinc finger protein 596","accession":"Q8TC21","gene":"ZNF596","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.4471580313422192,"antibodyCount":100,"monoclonalCount":14,"pubmedCount":null,"jensenScore":0.033333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.950939092426953,"pubTatorScore":-1.505149978319906,"self":"https://pharos.nih.gov/idg/api/v1/targets(12233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12233)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(12233)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12233)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12233)/publications"},"_namespace":null},{"id":12234,"version":3,"created":1554950573000,"modified":1555040560000,"deprecated":false,"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1","accession":"P19174","gene":"PLCG1","description":"Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.9033923611897796,"antibodyCount":846,"monoclonalCount":178,"pubmedCount":null,"jensenScore":786.199194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":61.652553462730985,"pubTatorScore":2.6514295069072014,"self":"https://pharos.nih.gov/idg/api/v1/targets(12234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(12234)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(12234)/links"},"_synonyms":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(12234)/synonyms"},"_publications":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(12234)/publications"},"_namespace":null},{"id":12235,"version":3,"created":1554950580000,"modified":1555040564000,"deprecated":false,"name":"Protein FAM234B","accession":"A2RU67","gene":"FAM234B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9956351945975499,"antibodyCount":21,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.097286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":34,"knowledgeAvailability":0.0,"pubTatorScore":-1.2787501266108712,"self":"https://pharos.nih.gov/idg/api/v1/targets(12235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12235)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(12235)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12235)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12235)/publications"},"_namespace":null},{"id":12236,"version":3,"created":1554950584000,"modified":1555040566000,"deprecated":false,"name":"Azurocidin","accession":"P20160","gene":"AZU1","description":"This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.496458529153748,"antibodyCount":194,"monoclonalCount":34,"pubmedCount":null,"jensenScore":282.232799,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":23.14176266677401,"pubTatorScore":2.2073930313184573,"self":"https://pharos.nih.gov/idg/api/v1/targets(12236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(12236)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(12236)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12236)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12236)/publications"},"_namespace":null},{"id":12237,"version":2,"created":1554950588000,"modified":1554950591000,"deprecated":false,"name":"Enkurin","accession":"Q8TC29","gene":"ENKUR","description":"Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3976535665135401,"antibodyCount":131,"monoclonalCount":51,"pubmedCount":null,"jensenScore":1.678788,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.718836022722275,"pubTatorScore":0.014240299019593509,"self":"https://pharos.nih.gov/idg/api/v1/targets(12237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(12237)/properties"},"_links":{"count":742,"href":"https://pharos.nih.gov/idg/api/v1/targets(12237)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12237)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12237)/publications"},"_namespace":null},{"id":12238,"version":2,"created":1554950592000,"modified":1554950595000,"deprecated":false,"name":"Protein kish-A","accession":"Q8TBQ9","gene":"TMEM167A","description":"Involved in the early part of the secretory pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.323074383937932,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(12238)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(12238)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12238)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12238)/publications"},"_namespace":null},{"id":12239,"version":2,"created":1554950595000,"modified":1554950599000,"deprecated":false,"name":"Transmembrane protein 163","accession":"Q8TC26","gene":"TMEM163","description":"May bind zinc and other divalent cations and recruit them to vesicular organelles.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0562730157577527,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.460051,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.46341823866342,"pubTatorScore":0.7891058308017396,"self":"https://pharos.nih.gov/idg/api/v1/targets(12239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12239)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(12239)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12239)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12239)/publications"},"_namespace":null},{"id":12240,"version":2,"created":1554950599000,"modified":1554950601000,"deprecated":false,"name":"Golgi apparatus membrane protein TVP23 homolog C","accession":"Q96ET8","gene":"TVP23C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":26,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.225321808405184,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(12240)/properties"},"_links":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(12240)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12240)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12240)/publications"},"_namespace":null},{"id":12241,"version":3,"created":1554950602000,"modified":1555040569000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 32","accession":"Q8TC27","gene":"ADAM32","description":"May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.1613680037550056,"antibodyCount":118,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.67549,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":25.84285757820551,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(12241)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(12241)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12241)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12241)/publications"},"_namespace":null},{"id":12242,"version":2,"created":1554950605000,"modified":1554950607000,"deprecated":false,"name":"Methyltransferase-like protein 24","accession":"Q5JXM2","gene":"METTL24","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.181529701583358,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(12242)/properties"},"_links":{"count":710,"href":"https://pharos.nih.gov/idg/api/v1/targets(12242)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12242)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12242)/publications"},"_namespace":null},{"id":12243,"version":2,"created":1554950607000,"modified":1554950610000,"deprecated":false,"name":"Actin-related protein 5","accession":"Q9H9F9","gene":"ACTR5","description":"Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.07525095271530231,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.954545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.53373827787741,"pubTatorScore":0.7317230614708109,"self":"https://pharos.nih.gov/idg/api/v1/targets(12243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(12243)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(12243)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12243)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12243)/publications"},"_namespace":null},{"id":12244,"version":3,"created":1554950611000,"modified":1555040571000,"deprecated":false,"name":"Neurofilament light polypeptide","accession":"P07196","gene":"NEFL","description":"Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":543,"monoclonalCount":321,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":42.38440723782828,"pubTatorScore":2.6615315454740225,"self":"https://pharos.nih.gov/idg/api/v1/targets(12244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(12244)/properties"},"_links":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(12244)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12244)/synonyms"},"_publications":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12244)/publications"},"_namespace":null},{"id":12245,"version":3,"created":1554950614000,"modified":1555040572000,"deprecated":false,"name":"L-lactate dehydrogenase B chain","accession":"P07195","gene":"LDHB","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.5007611866270305,"antibodyCount":241,"monoclonalCount":92,"pubmedCount":null,"jensenScore":306.010691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.52770885627788,"pubTatorScore":2.1794782133794945,"self":"https://pharos.nih.gov/idg/api/v1/targets(12245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":475,"href":"https://pharos.nih.gov/idg/api/v1/targets(12245)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(12245)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12245)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12245)/publications"},"_namespace":null},{"id":12246,"version":3,"created":1554950621000,"modified":1555040574000,"deprecated":false,"name":"Serine protease inhibitor Kazal-type 2","accession":"P20155","gene":"SPINK2","description":"Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.8891682632283471,"antibodyCount":33,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.15712,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":17.626909398273792,"pubTatorScore":1.0778094254969686,"self":"https://pharos.nih.gov/idg/api/v1/targets(12246)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(12246)/properties"},"_links":{"count":661,"href":"https://pharos.nih.gov/idg/api/v1/targets(12246)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12246)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12246)/publications"},"_namespace":null},{"id":12247,"version":3,"created":1554950624000,"modified":1555040575000,"deprecated":false,"name":"C-type lectin domain family 18 member A","accession":"A5D8T8","gene":"CLEC18A","description":"Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.933234113080207,"antibodyCount":94,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.090288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":12.838606084321624,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12247)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(12247)/properties"},"_links":{"count":760,"href":"https://pharos.nih.gov/idg/api/v1/targets(12247)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12247)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12247)/publications"},"_namespace":null},{"id":12248,"version":2,"created":1554950626000,"modified":1554950629000,"deprecated":false,"name":"40S ribosomal protein S10","accession":"P46783","gene":"RPS10","description":"Component of the 40S ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7690904598919008,"antibodyCount":141,"monoclonalCount":3,"pubmedCount":null,"jensenScore":55.280403,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.00574846566606,"pubTatorScore":1.9977071501124661,"self":"https://pharos.nih.gov/idg/api/v1/targets(12248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(12248)/properties"},"_links":{"count":1188,"href":"https://pharos.nih.gov/idg/api/v1/targets(12248)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12248)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12248)/publications"},"_namespace":null},{"id":12249,"version":3,"created":1554950630000,"modified":1555040576000,"deprecated":false,"name":"Neurofilament medium polypeptide","accession":"P07197","gene":"NEFM","description":"Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5509846836522136,"antibodyCount":468,"monoclonalCount":280,"pubmedCount":null,"jensenScore":344.048069,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":37.936290309362064,"pubTatorScore":2.0948586273068095,"self":"https://pharos.nih.gov/idg/api/v1/targets(12249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(12249)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(12249)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12249)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12249)/publications"},"_namespace":null},{"id":12250,"version":4,"created":1554950635000,"modified":1555040578000,"deprecated":false,"name":"Collagenase 3","accession":"P45452","gene":"MMP13","description":"Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.1217252941238267,"antibodyCount":772,"monoclonalCount":275,"pubmedCount":null,"jensenScore":1243.823539,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":36.86730759664073,"pubTatorScore":2.812788060647812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12250)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(12250)/properties"},"_links":{"count":2682,"href":"https://pharos.nih.gov/idg/api/v1/targets(12250)/links"},"_synonyms":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(12250)/synonyms"},"_publications":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12250)/publications"},"_namespace":null},{"id":12251,"version":2,"created":1554950976000,"modified":1554950978000,"deprecated":false,"name":"60S ribosomal protein L24","accession":"P83731","gene":"RPL24","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.5828406460931155,"antibodyCount":46,"monoclonalCount":2,"pubmedCount":null,"jensenScore":366.882178,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.17738271052032,"pubTatorScore":1.0692314374070335,"self":"https://pharos.nih.gov/idg/api/v1/targets(12251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(12251)/properties"},"_links":{"count":1114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12251)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12251)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12251)/publications"},"_namespace":null},{"id":12252,"version":2,"created":1554950979000,"modified":1554950983000,"deprecated":false,"name":"Major centromere autoantigen B","accession":"P07199","gene":"CENPB","description":"Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3129144773289725,"antibodyCount":93,"monoclonalCount":7,"pubmedCount":null,"jensenScore":207.84142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.50621476871757,"pubTatorScore":2.2913771543668897,"self":"https://pharos.nih.gov/idg/api/v1/targets(12252)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(12252)/properties"},"_links":{"count":1061,"href":"https://pharos.nih.gov/idg/api/v1/targets(12252)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12252)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12252)/publications"},"_namespace":null},{"id":12253,"version":2,"created":1554950984000,"modified":1554950987000,"deprecated":false,"name":"CSC1-like protein 2","accession":"Q5T3F8","gene":"TMEM63B","description":"Acts as an osmosensitive calcium-permeable cation channel.","idgFamily":"Ion Channel","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.666666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.23060204328398,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12253)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(12253)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(12253)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12253)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12253)/publications"},"_namespace":null},{"id":12254,"version":2,"created":1554950988000,"modified":1554950991000,"deprecated":false,"name":"TBC1 domain family member 16","accession":"Q8TBP0","gene":"TBC1D16","description":"May act as a GTPase-activating protein for Rab family protein(s).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.25937872171243515,"antibodyCount":50,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.396465,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.05590266874534,"pubTatorScore":0.3152702946835747,"self":"https://pharos.nih.gov/idg/api/v1/targets(12254)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(12254)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(12254)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12254)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12254)/publications"},"_namespace":null},{"id":12255,"version":3,"created":1554950992000,"modified":1555040584000,"deprecated":false,"name":"Retinol dehydrogenase 11","accession":"Q8TC12","gene":"RDH11","description":"Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.156823303719935,"antibodyCount":150,"monoclonalCount":35,"pubmedCount":null,"jensenScore":1370.122166,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.4184907346964,"pubTatorScore":1.2682531825809555,"self":"https://pharos.nih.gov/idg/api/v1/targets(12255)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(12255)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(12255)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12255)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12255)/publications"},"_namespace":null},{"id":12256,"version":2,"created":1554950997000,"modified":1554951001000,"deprecated":false,"name":"40S ribosomal protein S5","accession":"P46782","gene":"RPS5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0387801994175323,"antibodyCount":141,"monoclonalCount":45,"pubmedCount":null,"jensenScore":103.619675,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.620724713532525,"pubTatorScore":1.5031234129564914,"self":"https://pharos.nih.gov/idg/api/v1/targets(12256)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(12256)/properties"},"_links":{"count":1134,"href":"https://pharos.nih.gov/idg/api/v1/targets(12256)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12256)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12256)/publications"},"_namespace":null},{"id":12257,"version":2,"created":1554951002000,"modified":1554951005000,"deprecated":false,"name":"40S ribosomal protein S9","accession":"P46781","gene":"RPS9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4272951803218537,"antibodyCount":178,"monoclonalCount":9,"pubmedCount":null,"jensenScore":26.048986,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.29684840037585,"pubTatorScore":2.024098020328283,"self":"https://pharos.nih.gov/idg/api/v1/targets(12257)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(12257)/properties"},"_links":{"count":1104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12257)/links"},"_synonyms":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(12257)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(12257)/publications"},"_namespace":null},{"id":12258,"version":3,"created":1554951006000,"modified":1555040585000,"deprecated":false,"name":"GRB2-related adapter protein-like","accession":"Q8TC17","gene":"GRAPL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":10.386438342149104,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12258)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(12258)/properties"},"_links":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(12258)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12258)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12258)/publications"},"_namespace":null},{"id":12259,"version":2,"created":1554951008000,"modified":1554951011000,"deprecated":false,"name":"Zinc finger protein 503","accession":"Q96F45","gene":"ZNF503","description":"May function as a transcriptional repressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9631879651899047,"antibodyCount":120,"monoclonalCount":3,"pubmedCount":null,"jensenScore":10.461108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.367659567840626,"pubTatorScore":0.4232457100520668,"self":"https://pharos.nih.gov/idg/api/v1/targets(12259)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(12259)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(12259)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12259)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12259)/publications"},"_namespace":null},{"id":12260,"version":3,"created":1554951012000,"modified":1555040587000,"deprecated":false,"name":"E3 ubiquitin-protein ligase TRIM11","accession":"Q96F44","gene":"TRIM11","description":"E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4976754566429098,"antibodyCount":186,"monoclonalCount":2,"pubmedCount":null,"jensenScore":34.448583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":32.17981696135905,"pubTatorScore":1.1142605720631276,"self":"https://pharos.nih.gov/idg/api/v1/targets(12260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12260)/publications"},"_namespace":null},{"id":12261,"version":3,"created":1554951016000,"modified":1555040589000,"deprecated":false,"name":"Membrane protein FAM174A","accession":"Q8TBP5","gene":"FAM174A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2973957115879465,"antibodyCount":24,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.764881,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":44,"knowledgeAvailability":27.322767855200386,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(12261)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12261)/publications"},"_namespace":null},{"id":12262,"version":3,"created":1554951019000,"modified":1555040591000,"deprecated":false,"name":"SAGA-associated factor 29","accession":"Q96ES7","gene":"SGF29","description":"Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.7823450037709536,"antibodyCount":84,"monoclonalCount":0,"pubmedCount":null,"jensenScore":590.134005,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":39,"knowledgeAvailability":0.0,"pubTatorScore":0.8034246106311692,"self":"https://pharos.nih.gov/idg/api/v1/targets(12262)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12262)/publications"},"_namespace":null},{"id":12263,"version":2,"created":1554951022000,"modified":1554951024000,"deprecated":false,"name":"Major facilitator superfamily domain-containing protein 3","accession":"Q96ES6","gene":"MFSD3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.461538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.212894543695736,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/properties"},"_links":{"count":777,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12263)/publications"},"_namespace":null},{"id":12264,"version":2,"created":1554951025000,"modified":1554951028000,"deprecated":false,"name":"Solute carrier family 25 member 40","accession":"Q8TBP6","gene":"SLC25A40","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":-1.7510806593784407,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":56.302835,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.863686654831845,"pubTatorScore":1.0321108066990077,"self":"https://pharos.nih.gov/idg/api/v1/targets(12264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12264)/publications"},"_namespace":null},{"id":12265,"version":3,"created":1554951028000,"modified":1555040594000,"deprecated":false,"name":"Interleukin-17 receptor A","accession":"Q96F46","gene":"IL17RA","description":"Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.182862525381674,"antibodyCount":481,"monoclonalCount":257,"pubmedCount":null,"jensenScore":122.692102,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":56,"knowledgeAvailability":38.20005120630001,"pubTatorScore":1.955777173065571,"self":"https://pharos.nih.gov/idg/api/v1/targets(12265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12265)/publications"},"_namespace":null},{"id":12266,"version":2,"created":1554951035000,"modified":1554951048000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase FKBP1B","accession":"P68106","gene":"FKBP1B","description":"Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.0956756581480764,"antibodyCount":84,"monoclonalCount":9,"pubmedCount":null,"jensenScore":114.174161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.800204132635326,"pubTatorScore":1.9282044439553603,"self":"https://pharos.nih.gov/idg/api/v1/targets(12266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(12266)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(12266)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(12266)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12266)/publications"},"_namespace":null},{"id":12267,"version":3,"created":1554951049000,"modified":1555040595000,"deprecated":false,"name":"Elongation factor 1-alpha 1","accession":"P68104","gene":"EEF1A1","description":"This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.814219940739838,"antibodyCount":182,"monoclonalCount":12,"pubmedCount":null,"jensenScore":1183.028427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":51.985976949330606,"pubTatorScore":2.631142588939925,"self":"https://pharos.nih.gov/idg/api/v1/targets(12267)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":574,"href":"https://pharos.nih.gov/idg/api/v1/targets(12267)/properties"},"_links":{"count":1243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12267)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(12267)/synonyms"},"_publications":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(12267)/publications"},"_namespace":null},{"id":12268,"version":2,"created":1554951058000,"modified":1554951061000,"deprecated":false,"name":"Ankyrin repeat family A protein 2","accession":"Q9H9E1","gene":"ANKRA2","description":"May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5309209978238464,"antibodyCount":117,"monoclonalCount":27,"pubmedCount":null,"jensenScore":4.208218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.978105244224686,"pubTatorScore":0.6108881078626106,"self":"https://pharos.nih.gov/idg/api/v1/targets(12268)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(12268)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(12268)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12268)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12268)/publications"},"_namespace":null},{"id":12269,"version":3,"created":1554951062000,"modified":1555040597000,"deprecated":false,"name":"Conserved oligomeric Golgi complex subunit 4","accession":"Q9H9E3","gene":"COG4","description":"Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1443708612194126,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.253779,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":38.27266019966093,"pubTatorScore":1.384723759745117,"self":"https://pharos.nih.gov/idg/api/v1/targets(12269)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(12269)/properties"},"_links":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12269)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12269)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12269)/publications"},"_namespace":null},{"id":12270,"version":3,"created":1554951066000,"modified":1555040599000,"deprecated":false,"name":"26S proteasome non-ATPase regulatory subunit 5","accession":"Q16401","gene":"PSMD5","description":"Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5423412093669138,"antibodyCount":149,"monoclonalCount":26,"pubmedCount":null,"jensenScore":34.382997,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":37.058346225419236,"pubTatorScore":0.9485971106320461,"self":"https://pharos.nih.gov/idg/api/v1/targets(12270)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":480,"href":"https://pharos.nih.gov/idg/api/v1/targets(12270)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(12270)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(12270)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12270)/publications"},"_namespace":null},{"id":12271,"version":2,"created":1554951070000,"modified":1554951075000,"deprecated":false,"name":"60S ribosomal protein L5","accession":"P46777","gene":"RPL5","description":"Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0283113965160333,"antibodyCount":228,"monoclonalCount":1,"pubmedCount":null,"jensenScore":78.281871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.30697637985434,"pubTatorScore":2.5305832068589336,"self":"https://pharos.nih.gov/idg/api/v1/targets(12271)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":532,"href":"https://pharos.nih.gov/idg/api/v1/targets(12271)/properties"},"_links":{"count":1192,"href":"https://pharos.nih.gov/idg/api/v1/targets(12271)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12271)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12271)/publications"},"_namespace":null},{"id":12272,"version":2,"created":1554951076000,"modified":1554951079000,"deprecated":false,"name":"60S ribosomal protein L27a","accession":"P46776","gene":"RPL27A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2961091074891282,"antibodyCount":136,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.808863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.272698497732506,"pubTatorScore":0.573868637427402,"self":"https://pharos.nih.gov/idg/api/v1/targets(12272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(12272)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(12272)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12272)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12272)/publications"},"_namespace":null},{"id":12273,"version":3,"created":1554951080000,"modified":1555040602000,"deprecated":false,"name":"60S ribosomal protein L28","accession":"P46779","gene":"RPL28","description":"Component of the large ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5027578829836206,"antibodyCount":118,"monoclonalCount":2,"pubmedCount":null,"jensenScore":27.863163,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":65,"knowledgeAvailability":41.37769098670052,"pubTatorScore":1.2708354333608185,"self":"https://pharos.nih.gov/idg/api/v1/targets(12273)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(12273)/properties"},"_links":{"count":1194,"href":"https://pharos.nih.gov/idg/api/v1/targets(12273)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(12273)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12273)/publications"},"_namespace":null},{"id":12274,"version":2,"created":1554951084000,"modified":1554951088000,"deprecated":false,"name":"60S ribosomal protein L21","accession":"P46778","gene":"RPL21","description":"Component of the large ribosomal subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6825210588468134,"antibodyCount":50,"monoclonalCount":8,"pubmedCount":null,"jensenScore":46.085449,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.83896792379317,"pubTatorScore":1.314180495094349,"self":"https://pharos.nih.gov/idg/api/v1/targets(12274)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(12274)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(12274)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12274)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12274)/publications"},"_namespace":null},{"id":12275,"version":2,"created":1554951089000,"modified":1554951089000,"deprecated":false,"name":"WASH complex subunit 2D","accession":"Q5SRD0","gene":"WASHC2D","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12275)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12275)/properties"},"_links":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(12275)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12275)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12275)/publications"},"_namespace":null},{"id":12276,"version":2,"created":1554951089000,"modified":1554951092000,"deprecated":false,"name":"ATP synthase subunit f, mitochondrial","accession":"P56134","gene":"ATP5MF","description":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8186547078643056,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":63.471945,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.39630241439839564,"self":"https://pharos.nih.gov/idg/api/v1/targets(12276)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12276)/publications"},"_namespace":null},{"id":12277,"version":3,"created":1554951093000,"modified":1555040604000,"deprecated":false,"name":"Beta-arrestin-2","accession":"P32121","gene":"ARRB2","description":"Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7257566862959473,"antibodyCount":250,"monoclonalCount":31,"pubmedCount":null,"jensenScore":487.761127,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":47.825923146528865,"pubTatorScore":2.5326046158225837,"self":"https://pharos.nih.gov/idg/api/v1/targets(12277)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(12277)/properties"},"_links":{"count":1325,"href":"https://pharos.nih.gov/idg/api/v1/targets(12277)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12277)/synonyms"},"_publications":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12277)/publications"},"_namespace":null},{"id":12278,"version":2,"created":1554951100000,"modified":1554951101000,"deprecated":false,"name":"ASNSD1 upstream open reading frame protein","accession":"L0R819","gene":"ASDURF","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":103,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12278)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12278)/properties"},"_links":{"count":630,"href":"https://pharos.nih.gov/idg/api/v1/targets(12278)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12278)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12278)/publications"},"_namespace":null},{"id":12279,"version":3,"created":1554951102000,"modified":1555040606000,"deprecated":false,"name":"TBC1 domain family member 15","accession":"Q8TC07","gene":"TBC1D15","description":"Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5410539792326421,"antibodyCount":36,"monoclonalCount":1,"pubmedCount":null,"jensenScore":5.068721,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":39.85412059892347,"pubTatorScore":0.6832472000596148,"self":"https://pharos.nih.gov/idg/api/v1/targets(12279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(12279)/properties"},"_links":{"count":1087,"href":"https://pharos.nih.gov/idg/api/v1/targets(12279)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12279)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12279)/publications"},"_namespace":null},{"id":12280,"version":3,"created":1554951107000,"modified":1555040608000,"deprecated":false,"name":"Single-pass membrane and coiled-coil domain-containing protein 3","accession":"A2RU48","gene":"SMCO3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3010299956639812,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":14.024816246255728,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12280)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(12280)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(12280)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12280)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12280)/publications"},"_namespace":null},{"id":12281,"version":3,"created":1554951109000,"modified":1555040609000,"deprecated":false,"name":"Coiled-coil domain-containing protein 51","accession":"Q96ER9","gene":"CCDC51","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.40576534695952005,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":25.713111064709437,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(12281)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12281)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12281)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12281)/publications"},"_namespace":null},{"id":12282,"version":2,"created":1554951113000,"modified":1554951116000,"deprecated":false,"name":"Hydroxylysine kinase","accession":"A2RU49","gene":"HYKK","description":"Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.94105131458005,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.018093,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.724174115457547,"pubTatorScore":0.6495589591560686,"self":"https://pharos.nih.gov/idg/api/v1/targets(12282)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(12282)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(12282)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12282)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12282)/publications"},"_namespace":null},{"id":12283,"version":2,"created":1554951116000,"modified":1554951119000,"deprecated":false,"name":"Protein SAAL1","accession":"Q96ER3","gene":"SAAL1","description":"Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3010299956639812,"antibodyCount":85,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.581938188025276,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12283)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(12283)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(12283)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12283)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12283)/publications"},"_namespace":null},{"id":12284,"version":3,"created":1554951120000,"modified":1555040610000,"deprecated":false,"name":"Nuclear protein MDM1","accession":"Q8TC05","gene":"MDM1","description":"Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0634238824343907,"antibodyCount":98,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.296479,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.34621355184728,"pubTatorScore":0.7604380906007157,"self":"https://pharos.nih.gov/idg/api/v1/targets(12284)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12284)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(12284)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12284)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12284)/publications"},"_namespace":null},{"id":12285,"version":3,"created":1554951125000,"modified":1555040612000,"deprecated":false,"name":"Myeloid cell surface antigen CD33","accession":"P20138","gene":"CD33","description":"Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.927683915214556,"antibodyCount":1518,"monoclonalCount":1100,"pubmedCount":null,"jensenScore":774.442706,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.05562608203175,"pubTatorScore":2.948472331928456,"self":"https://pharos.nih.gov/idg/api/v1/targets(12285)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(12285)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(12285)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12285)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12285)/publications"},"_namespace":null},{"id":12286,"version":3,"created":1554951129000,"modified":1555040615000,"deprecated":false,"name":"Zinc finger protein 408","accession":"Q9H9D4","gene":"ZNF408","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.7075025855932261,"antibodyCount":108,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.393667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":51,"knowledgeAvailability":32.678716620069004,"pubTatorScore":0.41656129545077586,"self":"https://pharos.nih.gov/idg/api/v1/targets(12286)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(12286)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(12286)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12286)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12286)/publications"},"_namespace":null},{"id":12287,"version":2,"created":1554951133000,"modified":1554951139000,"deprecated":false,"name":"HLA class I histocompatibility antigen, B-82 alpha chain","accession":"Q29718","gene":"HLA-B","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8875247029897861,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1613.472112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.7801564385417628,"self":"https://pharos.nih.gov/idg/api/v1/targets(12287)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1929,"href":"https://pharos.nih.gov/idg/api/v1/targets(12287)/properties"},"_links":{"count":1505,"href":"https://pharos.nih.gov/idg/api/v1/targets(12287)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12287)/synonyms"},"_publications":{"count":1770,"href":"https://pharos.nih.gov/idg/api/v1/targets(12287)/publications"},"_namespace":null},{"id":12288,"version":2,"created":1554951143000,"modified":1554951146000,"deprecated":false,"name":"L-serine dehydratase/L-threonine deaminase","accession":"P20132","gene":"SDS","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2950742817277257,"antibodyCount":141,"monoclonalCount":57,"pubmedCount":null,"jensenScore":195.805233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.04482867800973,"pubTatorScore":2.3844938569239043,"self":"https://pharos.nih.gov/idg/api/v1/targets(12288)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12288)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(12288)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12288)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12288)/publications"},"_namespace":null},{"id":12289,"version":3,"created":1554951147000,"modified":1555040617000,"deprecated":false,"name":"Protein EVI2A","accession":"P22794","gene":"EVI2A","description":"May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2179729353222597,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.508823,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":22.49479791580415,"pubTatorScore":0.9815705038992472,"self":"https://pharos.nih.gov/idg/api/v1/targets(12289)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(12289)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(12289)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12289)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12289)/publications"},"_namespace":null},{"id":12290,"version":2,"created":1554951151000,"modified":1554951154000,"deprecated":false,"name":"Putative mitochondrial import inner membrane translocase subunit Tim23B","accession":"Q5SRD1","gene":"TIMM23B","description":"May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7740919341204614,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.833141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.273130358732119,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12290)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(12290)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(12290)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12290)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12290)/publications"},"_namespace":null},{"id":12291,"version":2,"created":1554951155000,"modified":1554951164000,"deprecated":false,"name":"fMet-Leu-Phe receptor","accession":"P21462","gene":"FPR1","description":"High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.4275245528076126,"antibodyCount":277,"monoclonalCount":31,"pubmedCount":null,"jensenScore":255.146265,"patentCount":21372,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.09309977251273,"pubTatorScore":3.4197468158052793,"self":"https://pharos.nih.gov/idg/api/v1/targets(12291)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(12291)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(12291)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12291)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12291)/publications"},"_namespace":null},{"id":12292,"version":2,"created":1554951165000,"modified":1554951167000,"deprecated":false,"name":"Carboxypeptidase N subunit 2","accession":"P22792","gene":"CPN2","description":"The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.33881855619146894,"antibodyCount":149,"monoclonalCount":5,"pubmedCount":null,"jensenScore":0.438596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.468671959379115,"pubTatorScore":1.1583624619359096,"self":"https://pharos.nih.gov/idg/api/v1/targets(12292)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12292)/properties"},"_links":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(12292)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12292)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12292)/publications"},"_namespace":null},{"id":12293,"version":2,"created":1554951168000,"modified":1554951173000,"deprecated":false,"name":"Collagen alpha-1(XIV) chain","accession":"Q05707","gene":"COL14A1","description":"Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.163066021326189,"antibodyCount":64,"monoclonalCount":24,"pubmedCount":null,"jensenScore":130.566724,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.38554246805262,"pubTatorScore":1.5682121470094859,"self":"https://pharos.nih.gov/idg/api/v1/targets(12293)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12293)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(12293)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12293)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12293)/publications"},"_namespace":null},{"id":12294,"version":2,"created":1554951174000,"modified":1554951174000,"deprecated":false,"name":"Homeobox protein HMX2","accession":"A2RU54","gene":"HMX2","description":"Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6909445884706198,"antibodyCount":144,"monoclonalCount":83,"pubmedCount":null,"jensenScore":35.728254,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.2592174985148,"pubTatorScore":1.1560344467455028,"self":"https://pharos.nih.gov/idg/api/v1/targets(12294)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12294)/properties"},"_links":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(12294)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12294)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12294)/publications"},"_namespace":null},{"id":12295,"version":2,"created":1554951175000,"modified":1554951178000,"deprecated":false,"name":"Small glutamine-rich tetratricopeptide repeat-containing protein beta","accession":"Q96EQ0","gene":"SGTB","description":"Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9502025421330349,"antibodyCount":86,"monoclonalCount":3,"pubmedCount":null,"jensenScore":9.398754,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.114453256997134,"pubTatorScore":0.6110146921704227,"self":"https://pharos.nih.gov/idg/api/v1/targets(12295)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12295)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(12295)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12295)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12295)/publications"},"_namespace":null},{"id":12296,"version":3,"created":1554951178000,"modified":1555040618000,"deprecated":false,"name":"Guanine nucleotide exchange factor for Rab-3A","accession":"Q8TBN0","gene":"RAB3IL1","description":"Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.498704337693606,"antibodyCount":115,"monoclonalCount":16,"pubmedCount":null,"jensenScore":35.535892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":33.472365802523534,"pubTatorScore":1.0169007339620757,"self":"https://pharos.nih.gov/idg/api/v1/targets(12296)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(12296)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(12296)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12296)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12296)/publications"},"_namespace":null},{"id":12297,"version":3,"created":1554951182000,"modified":1555040621000,"deprecated":false,"name":"Peroxiredoxin-2","accession":"P32119","gene":"PRDX2","description":"Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.571581710705554,"antibodyCount":364,"monoclonalCount":82,"pubmedCount":null,"jensenScore":368.400469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":46.106635961613094,"pubTatorScore":2.360553893619777,"self":"https://pharos.nih.gov/idg/api/v1/targets(12297)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(12297)/properties"},"_links":{"count":1184,"href":"https://pharos.nih.gov/idg/api/v1/targets(12297)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(12297)/synonyms"},"_publications":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12297)/publications"},"_namespace":null},{"id":12298,"version":3,"created":1554951189000,"modified":1555040623000,"deprecated":false,"name":"Kallikrein-2","accession":"P20151","gene":"KLK2","description":"Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.090374981179446,"antibodyCount":276,"monoclonalCount":53,"pubmedCount":null,"jensenScore":149.899903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":23.26246251905979,"pubTatorScore":2.179883359845285,"self":"https://pharos.nih.gov/idg/api/v1/targets(12298)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(12298)/properties"},"_links":{"count":716,"href":"https://pharos.nih.gov/idg/api/v1/targets(12298)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12298)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12298)/publications"},"_namespace":null},{"id":12299,"version":3,"created":1554951192000,"modified":1555040624000,"deprecated":false,"name":"Leucine-rich repeat and IQ domain-containing protein 3","accession":"A6PVS8","gene":"LRRIQ3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.1945746643877823,"antibodyCount":82,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.475491,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":23.33269332321664,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12299)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(12299)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(12299)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12299)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12299)/publications"},"_namespace":null},{"id":12300,"version":2,"created":1554951195000,"modified":1554951200000,"deprecated":false,"name":"Actin, alpha skeletal muscle","accession":"P68133","gene":"ACTA1","description":"Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.757901041978047,"antibodyCount":749,"monoclonalCount":397,"pubmedCount":null,"jensenScore":541.522638,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.73809487120452,"pubTatorScore":2.861115501218209,"self":"https://pharos.nih.gov/idg/api/v1/targets(12300)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":525,"href":"https://pharos.nih.gov/idg/api/v1/targets(12300)/properties"},"_links":{"count":1152,"href":"https://pharos.nih.gov/idg/api/v1/targets(12300)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12300)/synonyms"},"_publications":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12300)/publications"},"_namespace":null},{"id":12301,"version":2,"created":1554951202000,"modified":1554951206000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF125","accession":"Q96EQ8","gene":"RNF125","description":"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8282812964521289,"antibodyCount":139,"monoclonalCount":24,"pubmedCount":null,"jensenScore":7.886795,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.31862798317194,"pubTatorScore":1.0320913651768984,"self":"https://pharos.nih.gov/idg/api/v1/targets(12301)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(12301)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(12301)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12301)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12301)/publications"},"_namespace":null},{"id":12302,"version":3,"created":1554951207000,"modified":1555040625000,"deprecated":false,"name":"UDP-N-acetylglucosamine transferase subunit ALG14 homolog","accession":"Q96F25","gene":"ALG14","description":"May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7142598757469559,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.593327,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.691105885234574,"pubTatorScore":0.2477393713888053,"self":"https://pharos.nih.gov/idg/api/v1/targets(12302)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(12302)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(12302)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12302)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12302)/publications"},"_namespace":null},{"id":12303,"version":3,"created":1554951210000,"modified":1555040626000,"deprecated":false,"name":"Nuclear receptor-binding factor 2","accession":"Q96F24","gene":"NRBF2","description":"Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6924412827267417,"antibodyCount":174,"monoclonalCount":54,"pubmedCount":null,"jensenScore":53.275685,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":31.97065549108309,"pubTatorScore":1.202220110545514,"self":"https://pharos.nih.gov/idg/api/v1/targets(12303)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(12303)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(12303)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12303)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12303)/publications"},"_namespace":null},{"id":12304,"version":2,"created":1554951214000,"modified":1554951218000,"deprecated":false,"name":"C2 domain-containing protein 3","accession":"Q4AC94","gene":"C2CD3","description":"Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7189460099385178,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.31555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.22781868762284,"pubTatorScore":0.8414163505460095,"self":"https://pharos.nih.gov/idg/api/v1/targets(12304)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(12304)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(12304)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12304)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12304)/publications"},"_namespace":null},{"id":12305,"version":3,"created":1554951219000,"modified":1555040627000,"deprecated":false,"name":"DnaJ homolog subfamily B member 14","accession":"Q8TBM8","gene":"DNAJB14","description":"(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-9.549421973421906E-4,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.361851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.07043924417358,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(12305)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12305)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(12305)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12305)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12305)/publications"},"_namespace":null},{"id":12306,"version":2,"created":1554951223000,"modified":1554951226000,"deprecated":false,"name":"Sodium/bile acid cotransporter 4","accession":"Q96EP9","gene":"SLC10A4","description":"Transporter for bile acids.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.8899016906974027,"antibodyCount":77,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.976469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.81155192057662,"pubTatorScore":2.413953768276955,"self":"https://pharos.nih.gov/idg/api/v1/targets(12306)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(12306)/properties"},"_links":{"count":742,"href":"https://pharos.nih.gov/idg/api/v1/targets(12306)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12306)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12306)/publications"},"_namespace":null},{"id":12307,"version":2,"created":1554951226000,"modified":1554951228000,"deprecated":false,"name":"Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2","accession":"Q4AC99","gene":"ACCSL","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.704076301813167,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12307)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12307)/properties"},"_links":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(12307)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12307)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12307)/publications"},"_namespace":null},{"id":12308,"version":2,"created":1554951228000,"modified":1554951231000,"deprecated":false,"name":"Nucleoporin NUP188 homolog","accession":"Q5SRE5","gene":"NUP188","description":"May function as a component of the nuclear pore complex (NPC).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7518607029465855,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.317478,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.58692326971406,"pubTatorScore":0.6030927090815623,"self":"https://pharos.nih.gov/idg/api/v1/targets(12308)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(12308)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(12308)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12308)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12308)/publications"},"_namespace":null},{"id":12309,"version":2,"created":1554951232000,"modified":1554951236000,"deprecated":false,"name":"Spermatogenesis-defective protein 39 homolog","accession":"Q9H9C1","gene":"VIPAS39","description":"Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4433251307590034,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":27.167352,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.19613986845166,"pubTatorScore":1.2593037267787508,"self":"https://pharos.nih.gov/idg/api/v1/targets(12309)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(12309)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12309)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12309)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12309)/publications"},"_namespace":null},{"id":12310,"version":2,"created":1554951237000,"modified":1554951243000,"deprecated":false,"name":"Gastricsin","accession":"P20142","gene":"PGC","description":"Hydrolyzes a variety of proteins.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.7444477063749777,"antibodyCount":286,"monoclonalCount":70,"pubmedCount":null,"jensenScore":526.551374,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.690962237729266,"pubTatorScore":2.506438549142987,"self":"https://pharos.nih.gov/idg/api/v1/targets(12310)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(12310)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(12310)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12310)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12310)/publications"},"_namespace":null},{"id":12311,"version":3,"created":1554951244000,"modified":1555040629000,"deprecated":false,"name":"Archaemetzincin-1","accession":"Q400G9","gene":"AMZ1","description":"Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.722223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":20.92109419990856,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(12311)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(12311)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(12311)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12311)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12311)/publications"},"_namespace":null},{"id":12312,"version":2,"created":1554951247000,"modified":1554951250000,"deprecated":false,"name":"Phytanoyl-CoA dioxygenase domain-containing protein 1","accession":"Q5SRE7","gene":"PHYHD1","description":"Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA. Isoform 2 and isoform 3 probably lack enzyme activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4573771956553163,"antibodyCount":99,"monoclonalCount":6,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.124564232122694,"pubTatorScore":0.2041199826559248,"self":"https://pharos.nih.gov/idg/api/v1/targets(12312)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(12312)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(12312)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12312)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12312)/publications"},"_namespace":null},{"id":12313,"version":2,"created":1554951251000,"modified":1554951254000,"deprecated":false,"name":"RING finger and transmembrane domain-containing protein 2","accession":"Q96EX2","gene":"RNFT2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.854841702365835,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12313)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(12313)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(12313)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12313)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12313)/publications"},"_namespace":null},{"id":12314,"version":3,"created":1554951255000,"modified":1555040630000,"deprecated":false,"name":"Small integral membrane protein 12","accession":"Q96EX1","gene":"SMIM12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":20.32320685433652,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12314)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(12314)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(12314)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12314)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12314)/publications"},"_namespace":null},{"id":12315,"version":2,"created":1554951258000,"modified":1554951261000,"deprecated":false,"name":"Ligand-dependent nuclear receptor-interacting factor 1","accession":"Q5T3J3","gene":"LRIF1","description":"Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repression may occur through direct recruitment of histone deacetylases.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5118833577216657,"antibodyCount":69,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.937056,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.840332687080593,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(12315)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(12315)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(12315)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12315)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12315)/publications"},"_namespace":null},{"id":12316,"version":3,"created":1554951262000,"modified":1555040631000,"deprecated":false,"name":"WD repeat-containing protein 34","accession":"Q96EX3","gene":"WDR34","description":"Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9343359365212687,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.52995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":31.373623083684134,"pubTatorScore":0.8237535615200834,"self":"https://pharos.nih.gov/idg/api/v1/targets(12316)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(12316)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(12316)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12316)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12316)/publications"},"_namespace":null},{"id":12317,"version":3,"created":1554951266000,"modified":1555040633000,"deprecated":false,"name":"Glycerol kinase","accession":"P32189","gene":"GK","description":"Key enzyme in the regulation of glycerol uptake and metabolism.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.8469211643251227,"antibodyCount":238,"monoclonalCount":17,"pubmedCount":null,"jensenScore":109.034917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":42.01071754214076,"pubTatorScore":1.9136940288373547,"self":"https://pharos.nih.gov/idg/api/v1/targets(12317)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(12317)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(12317)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12317)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12317)/publications"},"_namespace":null},{"id":12318,"version":2,"created":1554951272000,"modified":1554951275000,"deprecated":false,"name":"39S ribosomal protein L44, mitochondrial","accession":"Q9H9J2","gene":"MRPL44","description":"Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.3891660793701459,"antibodyCount":85,"monoclonalCount":9,"pubmedCount":null,"jensenScore":2.538462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.10657039374956,"pubTatorScore":0.568201724066995,"self":"https://pharos.nih.gov/idg/api/v1/targets(12318)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(12318)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(12318)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12318)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12318)/publications"},"_namespace":null},{"id":12319,"version":3,"created":1554951276000,"modified":1555040634000,"deprecated":false,"name":"Platelet-activating factor acetylhydrolase IB subunit gamma","accession":"Q15102","gene":"PAFAH1B3","description":"Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8495559040755403,"antibodyCount":142,"monoclonalCount":69,"pubmedCount":null,"jensenScore":4.853931,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.78324599157869,"pubTatorScore":0.8583365456707537,"self":"https://pharos.nih.gov/idg/api/v1/targets(12319)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(12319)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(12319)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12319)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12319)/publications"},"_namespace":null},{"id":12320,"version":3,"created":1554951281000,"modified":1555040638000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 42","accession":"Q9H9J4","gene":"USP42","description":"Deubiquitinating enzyme which may play an important role during spermatogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.722908007129251,"antibodyCount":75,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.000799,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.80936313566576,"pubTatorScore":0.7229079844338242,"self":"https://pharos.nih.gov/idg/api/v1/targets(12320)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(12320)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(12320)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12320)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12320)/publications"},"_namespace":null},{"id":12321,"version":3,"created":1554951285000,"modified":1555040639000,"deprecated":false,"name":"CB1 cannabinoid receptor-interacting protein 1","accession":"Q96F85","gene":"CNRIP1","description":"Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.044023345187665,"antibodyCount":70,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.532841,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":25.08775000171975,"pubTatorScore":0.17784256245358404,"self":"https://pharos.nih.gov/idg/api/v1/targets(12321)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12321)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(12321)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12321)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12321)/publications"},"_namespace":null},{"id":12322,"version":2,"created":1554951290000,"modified":1554951290000,"deprecated":false,"name":"Protein FAM236B","accession":"A0A1B0GV22","gene":"FAM236B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12322)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12322)/properties"},"_links":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12322)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12322)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12322)/publications"},"_namespace":null},{"id":12323,"version":2,"created":1554951290000,"modified":1554951291000,"deprecated":false,"name":"Protein FAM71B","accession":"Q8TC56","gene":"FAM71B","description":"May be involved in RNA biogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.23408320494763177,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.287037,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.862225215924434,"pubTatorScore":-0.23408345420171428,"self":"https://pharos.nih.gov/idg/api/v1/targets(12323)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12323)/properties"},"_links":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(12323)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12323)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12323)/publications"},"_namespace":null},{"id":12324,"version":3,"created":1554951291000,"modified":1555040641000,"deprecated":false,"name":"Protein TESPA1","accession":"A2RU30","gene":"TESPA1","description":"Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7368389803191514,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.43047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":23.851994384342685,"pubTatorScore":0.7269987007928563,"self":"https://pharos.nih.gov/idg/api/v1/targets(12324)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(12324)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(12324)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12324)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12324)/publications"},"_namespace":null},{"id":12325,"version":3,"created":1554951295000,"modified":1555040642000,"deprecated":false,"name":"Enhancer of mRNA-decapping protein 3","accession":"Q96F86","gene":"EDC3","description":"Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.448319740613005,"antibodyCount":151,"monoclonalCount":39,"pubmedCount":null,"jensenScore":28.056234,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.82011829377091,"pubTatorScore":0.9286274312982455,"self":"https://pharos.nih.gov/idg/api/v1/targets(12325)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(12325)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(12325)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12325)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12325)/publications"},"_namespace":null},{"id":12326,"version":3,"created":1554951299000,"modified":1555040643000,"deprecated":false,"name":"Protein dispatched homolog 1","accession":"Q96F81","gene":"DISP1","description":"Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.113987544018662,"antibodyCount":102,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.021141,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":25.94454823809704,"pubTatorScore":0.9392138911808202,"self":"https://pharos.nih.gov/idg/api/v1/targets(12326)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12326)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(12326)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12326)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12326)/publications"},"_namespace":null},{"id":12327,"version":2,"created":1554951303000,"modified":1554951303000,"deprecated":false,"name":"Protein FAM236A","accession":"A0A1B0GUQ0","gene":"FAM236B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12327)/properties"},"_links":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12327)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12327)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12327)/publications"},"_namespace":null},{"id":12328,"version":3,"created":1554951303000,"modified":1555040644000,"deprecated":false,"name":"Uncharacterized protein CLBA1","accession":"Q96F83","gene":"CLBA1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.2,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(12328)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(12328)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12328)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12328)/publications"},"_namespace":null},{"id":12329,"version":2,"created":1554951305000,"modified":1554951313000,"deprecated":false,"name":"Advanced glycosylation end product-specific receptor","accession":"Q15109","gene":"AGER","description":"Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.291449935588867,"antibodyCount":589,"monoclonalCount":84,"pubmedCount":null,"jensenScore":187.343661,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.328221521805446,"pubTatorScore":2.8744753652763744,"self":"https://pharos.nih.gov/idg/api/v1/targets(12329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/properties"},"_links":{"count":1552,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/links"},"_synonyms":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/synonyms"},"_publications":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(12329)/publications"},"_namespace":null},{"id":12330,"version":3,"created":1554951316000,"modified":1555040645000,"deprecated":false,"name":"HSPB1-associated protein 1","accession":"Q96EW2","gene":"HSPBAP1","description":"May play a role in cellular stress response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.521078566855061,"antibodyCount":155,"monoclonalCount":22,"pubmedCount":null,"jensenScore":31.630562,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.883811963364046,"pubTatorScore":1.1274334737769847,"self":"https://pharos.nih.gov/idg/api/v1/targets(12330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12330)/publications"},"_namespace":null},{"id":12331,"version":2,"created":1554951321000,"modified":1554951321000,"deprecated":false,"name":"Uncharacterized protein C9orf170","accession":"A2RU37","gene":"C9orf170","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12331)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/properties"},"_links":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12331)/publications"},"_namespace":null},{"id":12332,"version":2,"created":1554951321000,"modified":1554951321000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 18","accession":"D6R9N7","gene":"USP17L18","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.3366485642104666,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12332)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/properties"},"_links":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12332)/publications"},"_namespace":null},{"id":12333,"version":2,"created":1554951321000,"modified":1554951324000,"deprecated":false,"name":"Prestin","accession":"P58743","gene":"SLC26A5","description":"Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-3.1040087128936196,"antibodyCount":99,"monoclonalCount":10,"pubmedCount":null,"jensenScore":1262.97074,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.008499376827803,"pubTatorScore":1.6988045152982945,"self":"https://pharos.nih.gov/idg/api/v1/targets(12333)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12333)/publications"},"_namespace":null},{"id":12334,"version":2,"created":1554951325000,"modified":1554951328000,"deprecated":false,"name":"Meiosis 1 arrest protein","accession":"Q8TC57","gene":"M1AP","description":"Required for meiosis I progression during spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4784977848720299,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.533766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.060571133865814,"pubTatorScore":0.32451106865589924,"self":"https://pharos.nih.gov/idg/api/v1/targets(12334)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12334)/publications"},"_namespace":null},{"id":12335,"version":2,"created":1554951328000,"modified":1554951329000,"deprecated":false,"name":"Immunoglobulin kappa variable 2-40","accession":"A0A087WW87","gene":"IGKV2-40","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.9616895818744866,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12335)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12335)/publications"},"_namespace":null},{"id":12336,"version":2,"created":1554951329000,"modified":1554951332000,"deprecated":false,"name":"Piwi-like protein 2","accession":"Q8TC59","gene":"PIWIL2","description":"Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2046045781228267,"antibodyCount":204,"monoclonalCount":12,"pubmedCount":null,"jensenScore":154.806637,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.8248314882723,"pubTatorScore":1.7962911724941337,"self":"https://pharos.nih.gov/idg/api/v1/targets(12336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12336)/publications"},"_namespace":null},{"id":12337,"version":3,"created":1554951333000,"modified":1555040647000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit alpha-6","accession":"Q16445","gene":"GABRA6","description":"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.307945752433831,"antibodyCount":145,"monoclonalCount":1,"pubmedCount":null,"jensenScore":19.330286,"patentCount":777,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":26.02947941923013,"pubTatorScore":1.5009237466787857,"self":"https://pharos.nih.gov/idg/api/v1/targets(12337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12337)/publications"},"_namespace":null},{"id":12338,"version":2,"created":1554951376000,"modified":1554951379000,"deprecated":false,"name":"Procollagen C-endopeptidase enhancer 1","accession":"Q15113","gene":"PCOLCE","description":"C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7384894755016886,"antibodyCount":153,"monoclonalCount":34,"pubmedCount":null,"jensenScore":56.578185,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.958778801514576,"pubTatorScore":1.644465936356852,"self":"https://pharos.nih.gov/idg/api/v1/targets(12338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12338)/publications"},"_namespace":null},{"id":12339,"version":2,"created":1554951380000,"modified":1554951385000,"deprecated":false,"name":"Inactive phospholipase C-like protein 1","accession":"Q15111","gene":"PLCL1","description":"Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2252611993026203,"antibodyCount":97,"monoclonalCount":2,"pubmedCount":null,"jensenScore":167.932251,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.17620006126883,"pubTatorScore":1.8223339952553657,"self":"https://pharos.nih.gov/idg/api/v1/targets(12339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":428,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12339)/publications"},"_namespace":null},{"id":12340,"version":4,"created":1554951385000,"modified":1555040648000,"deprecated":false,"name":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial","accession":"Q15118","gene":"PDK1","description":"Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.0915553026783293,"antibodyCount":601,"monoclonalCount":108,"pubmedCount":null,"jensenScore":10.286604,"patentCount":42947,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":45.84719964610428,"pubTatorScore":2.5438940187102617,"self":"https://pharos.nih.gov/idg/api/v1/targets(12340)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12340)/publications"},"_namespace":null},{"id":12341,"version":3,"created":1554951427000,"modified":1555040649000,"deprecated":false,"name":"POC1 centriolar protein homolog B","accession":"Q8TC44","gene":"POC1B","description":"Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8131996206301418,"antibodyCount":87,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.621819,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":34.1775538374028,"pubTatorScore":0.8398968044687379,"self":"https://pharos.nih.gov/idg/api/v1/targets(12341)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(12341)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(12341)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12341)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12341)/publications"},"_namespace":null},{"id":12342,"version":3,"created":1554951431000,"modified":1555040652000,"deprecated":false,"name":"Programmed cell death protein 1","accession":"Q15116","gene":"PDCD1","description":"Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.9328956520983684,"antibodyCount":1357,"monoclonalCount":847,"pubmedCount":null,"jensenScore":839.241304,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":31.17744136734998,"pubTatorScore":2.9641641668711864,"self":"https://pharos.nih.gov/idg/api/v1/targets(12342)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":764,"href":"https://pharos.nih.gov/idg/api/v1/targets(12342)/properties"},"_links":{"count":1240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12342)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(12342)/synonyms"},"_publications":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(12342)/publications"},"_namespace":null},{"id":12343,"version":3,"created":1554951438000,"modified":1555040654000,"deprecated":false,"name":"RNA-binding protein 33","accession":"Q96EV2","gene":"RBM33","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5047529575894428,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.896334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.801207281418115,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(12343)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(12343)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(12343)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12343)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12343)/publications"},"_namespace":null},{"id":12344,"version":3,"created":1554951443000,"modified":1555040656000,"deprecated":false,"name":"Probable E3 ubiquitin-protein ligase RNF217","accession":"Q8TC41","gene":"RNF217","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.3222192947339193,"antibodyCount":105,"monoclonalCount":26,"pubmedCount":null,"jensenScore":0.616369,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":21.96585172563311,"pubTatorScore":-0.38021089427615945,"self":"https://pharos.nih.gov/idg/api/v1/targets(12344)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(12344)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(12344)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12344)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12344)/publications"},"_namespace":null},{"id":12345,"version":2,"created":1554951447000,"modified":1554951477000,"deprecated":false,"name":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial","accession":"Q15119","gene":"PDK2","description":"Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.688391493029035,"antibodyCount":414,"monoclonalCount":109,"pubmedCount":null,"jensenScore":45.121119,"patentCount":5561,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.668708559847936,"pubTatorScore":1.7734868685837402,"self":"https://pharos.nih.gov/idg/api/v1/targets(12345)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":420,"href":"https://pharos.nih.gov/idg/api/v1/targets(12345)/properties"},"_links":{"count":1209,"href":"https://pharos.nih.gov/idg/api/v1/targets(12345)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12345)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12345)/publications"},"_namespace":null},{"id":12346,"version":2,"created":1554951478000,"modified":1554951479000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 24","accession":"Q50LG9","gene":"LRRC24","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.654296533207763,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(12346)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(12346)/properties"},"_links":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(12346)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12346)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12346)/publications"},"_namespace":null},{"id":12347,"version":3,"created":1554951479000,"modified":1555040657000,"deprecated":false,"name":"Toll/interleukin-1 receptor domain-containing adapter protein","accession":"P58753","gene":"TIRAP","description":"Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9602667222737717,"antibodyCount":401,"monoclonalCount":29,"pubmedCount":null,"jensenScore":90.896961,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.10306001226371,"pubTatorScore":1.8722557351973932,"self":"https://pharos.nih.gov/idg/api/v1/targets(12347)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(12347)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(12347)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12347)/synonyms"},"_publications":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12347)/publications"},"_namespace":null},{"id":12348,"version":3,"created":1554951485000,"modified":1555040659000,"deprecated":false,"name":"Dysbindin","accession":"Q96EV8","gene":"DTNBP1","description":"Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4397979637851392,"antibodyCount":321,"monoclonalCount":25,"pubmedCount":null,"jensenScore":286.591502,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":63,"knowledgeAvailability":44.127115578089466,"pubTatorScore":2.3865575191245174,"self":"https://pharos.nih.gov/idg/api/v1/targets(12348)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(12348)/properties"},"_links":{"count":1328,"href":"https://pharos.nih.gov/idg/api/v1/targets(12348)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12348)/synonyms"},"_publications":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(12348)/publications"},"_namespace":null},{"id":12349,"version":3,"created":1554951491000,"modified":1555040661000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 37B","accession":"Q9H9H4","gene":"VPS37B","description":"Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3621067242734381,"antibodyCount":64,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.81545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":34.44164513864061,"pubTatorScore":0.004116648137179551,"self":"https://pharos.nih.gov/idg/api/v1/targets(12349)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(12349)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(12349)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12349)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12349)/publications"},"_namespace":null},{"id":12350,"version":2,"created":1554951495000,"modified":1554951499000,"deprecated":false,"name":"Astrocytic phosphoprotein PEA-15","accession":"Q15121","gene":"PEA15","description":"Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.955266261482562,"antibodyCount":355,"monoclonalCount":3,"pubmedCount":null,"jensenScore":108.943412,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.15138482686988,"pubTatorScore":1.7163865563212068,"self":"https://pharos.nih.gov/idg/api/v1/targets(12350)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(12350)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(12350)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12350)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12350)/publications"},"_namespace":null},{"id":12351,"version":3,"created":1554951500000,"modified":1555040663000,"deprecated":false,"name":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial","accession":"Q15120","gene":"PDK3","description":"Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.4536048242799496,"antibodyCount":226,"monoclonalCount":38,"pubmedCount":null,"jensenScore":2.386105,"patentCount":1328,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":36.44981861640129,"pubTatorScore":1.3092976771709197,"self":"https://pharos.nih.gov/idg/api/v1/targets(12351)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(12351)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(12351)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12351)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12351)/publications"},"_namespace":null},{"id":12352,"version":2,"created":1554951505000,"modified":1554951508000,"deprecated":false,"name":"MAP6 domain-containing protein 1","accession":"Q9H9H5","gene":"MAP6D1","description":"May have microtubule-stabilizing activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0253546314556212,"antibodyCount":13,"monoclonalCount":1,"pubmedCount":null,"jensenScore":10.54881,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.11169709397193,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(12352)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12352)/properties"},"_links":{"count":831,"href":"https://pharos.nih.gov/idg/api/v1/targets(12352)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12352)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12352)/publications"},"_namespace":null},{"id":12353,"version":3,"created":1554951508000,"modified":1555040664000,"deprecated":false,"name":"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase","accession":"Q15125","gene":"EBP","description":"Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.0326556470474624,"antibodyCount":137,"monoclonalCount":0,"pubmedCount":null,"jensenScore":104.174156,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.850849359568606,"pubTatorScore":2.679222550348132,"self":"https://pharos.nih.gov/idg/api/v1/targets(12353)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(12353)/properties"},"_links":{"count":1136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12353)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12353)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12353)/publications"},"_namespace":null},{"id":12354,"version":2,"created":1554951537000,"modified":1554951542000,"deprecated":false,"name":"Phosphoglucomutase-like protein 5","accession":"Q15124","gene":"PGM5","description":"Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9733111445664141,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.205575,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.655703243507872,"pubTatorScore":0.7929750033828429,"self":"https://pharos.nih.gov/idg/api/v1/targets(12354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(12354)/properties"},"_links":{"count":989,"href":"https://pharos.nih.gov/idg/api/v1/targets(12354)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12354)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12354)/publications"},"_namespace":null},{"id":12355,"version":2,"created":1554951543000,"modified":1554951546000,"deprecated":false,"name":"Tetratricopeptide repeat protein 39A","accession":"Q5SRH9","gene":"TTC39A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.146128035678238,"antibodyCount":19,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.136364,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.90196262265452,"pubTatorScore":0.045757447131224746,"self":"https://pharos.nih.gov/idg/api/v1/targets(12355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(12355)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(12355)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12355)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12355)/publications"},"_namespace":null},{"id":12356,"version":3,"created":1554951547000,"modified":1555040666000,"deprecated":false,"name":"Coiled-coil domain-containing protein 97","accession":"Q96F63","gene":"CCDC97","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":96,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":25.824246348711384,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(12356)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(12356)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(12356)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12356)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12356)/publications"},"_namespace":null},{"id":12357,"version":3,"created":1554951551000,"modified":1555040669000,"deprecated":false,"name":"G patch domain-containing protein 4","accession":"Q5T3I0","gene":"GPATCH4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.647817481454343,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.173611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":76,"knowledgeAvailability":32.2343120510271,"pubTatorScore":-0.6312186543638748,"self":"https://pharos.nih.gov/idg/api/v1/targets(12357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(12357)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(12357)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12357)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12357)/publications"},"_namespace":null},{"id":12358,"version":2,"created":1554951554000,"modified":1554951559000,"deprecated":false,"name":"Phosphomevalonate kinase","accession":"Q15126","gene":"PMVK","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.9638499706458636,"antibodyCount":144,"monoclonalCount":34,"pubmedCount":null,"jensenScore":92.322925,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.49263426002438,"pubTatorScore":1.5399120636995751,"self":"https://pharos.nih.gov/idg/api/v1/targets(12358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(12358)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(12358)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12358)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12358)/publications"},"_namespace":null},{"id":12359,"version":2,"created":1554951560000,"modified":1554951561000,"deprecated":false,"name":"Putative STAG3-like protein 4","accession":"Q8TBR4","gene":"STAG3L4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.83462108077966,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12359)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12359)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12359)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12359)/publications"},"_namespace":null},{"id":12360,"version":3,"created":1554951561000,"modified":1555040670000,"deprecated":false,"name":"Transmembrane protein 218","accession":"A2RU14","gene":"TMEM218","description":"May be involved in ciliary biogenesis or function.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.03218468270325591,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.060606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":19.00417730269132,"pubTatorScore":-0.23888214682107153,"self":"https://pharos.nih.gov/idg/api/v1/targets(12360)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(12360)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(12360)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12360)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12360)/publications"},"_namespace":null},{"id":12361,"version":2,"created":1554951564000,"modified":1554951567000,"deprecated":false,"name":"Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase","accession":"Q3LIE5","gene":"ADPRM","description":"Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.8335720472730132,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.141292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.381910643570453,"pubTatorScore":-0.04346564806588411,"self":"https://pharos.nih.gov/idg/api/v1/targets(12361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(12361)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(12361)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12361)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12361)/publications"},"_namespace":null},{"id":12362,"version":2,"created":1554951567000,"modified":1554951571000,"deprecated":false,"name":"C1GALT1-specific chaperone 1","accession":"Q96EU7","gene":"C1GALT1C1","description":"Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.063369154543792,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":115.083202,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.754900137627274,"pubTatorScore":1.7494142077462798,"self":"https://pharos.nih.gov/idg/api/v1/targets(12362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(12362)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(12362)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12362)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12362)/publications"},"_namespace":null},{"id":12363,"version":2,"created":1554951572000,"modified":1554951572000,"deprecated":false,"name":"Putative uncharacterized protein CIRBP-AS1","accession":"Q8TBR5","gene":"CIRBP-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.619150046855578,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12363)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12363)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12363)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12363)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12363)/publications"},"_namespace":null},{"id":12364,"version":3,"created":1554951572000,"modified":1555040671000,"deprecated":false,"name":"Ribosomal RNA processing protein 36 homolog","accession":"Q96EU6","gene":"RRP36","description":"Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.27300127206373764,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.825,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.121470677922456,"pubTatorScore":0.21307473667731525,"self":"https://pharos.nih.gov/idg/api/v1/targets(12364)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(12364)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(12364)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12364)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12364)/publications"},"_namespace":null},{"id":12365,"version":2,"created":1554951576000,"modified":1554951578000,"deprecated":false,"name":"SUN domain-containing protein 5","accession":"Q8TC36","gene":"SUN5","description":"May be involved in meiotic stage of spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.08931621713595,"antibodyCount":64,"monoclonalCount":1,"pubmedCount":null,"jensenScore":15.320237,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.537391194496617,"pubTatorScore":0.7923916894982539,"self":"https://pharos.nih.gov/idg/api/v1/targets(12365)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12365)/properties"},"_links":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(12365)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12365)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12365)/publications"},"_namespace":null},{"id":12366,"version":2,"created":1554951578000,"modified":1554951581000,"deprecated":false,"name":"Protein FAM57A","accession":"Q8TBR7","gene":"FAM57A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0130045050251808,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.463514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.993717849331226,"pubTatorScore":0.8709401209497597,"self":"https://pharos.nih.gov/idg/api/v1/targets(12366)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(12366)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(12366)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12366)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12366)/publications"},"_namespace":null},{"id":12367,"version":3,"created":1554951582000,"modified":1555040672000,"deprecated":false,"name":"Protein argonaute-3","accession":"Q9H9G7","gene":"AGO3","description":"Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3075217267572652,"antibodyCount":127,"monoclonalCount":37,"pubmedCount":null,"jensenScore":14.410582,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":31.77097033943951,"pubTatorScore":1.2208652975771552,"self":"https://pharos.nih.gov/idg/api/v1/targets(12367)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(12367)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(12367)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12367)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12367)/publications"},"_namespace":null},{"id":12368,"version":3,"created":1554951586000,"modified":1555040673000,"deprecated":false,"name":"Cyclin-dependent kinase 10","accession":"Q15131","gene":"CDK10","description":"Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.3983136626207118,"antibodyCount":240,"monoclonalCount":3,"pubmedCount":null,"jensenScore":27.665397,"patentCount":5072,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":37.832898579926784,"pubTatorScore":1.4219157337614923,"self":"https://pharos.nih.gov/idg/api/v1/targets(12368)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(12368)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(12368)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(12368)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12368)/publications"},"_namespace":null},{"id":12369,"version":2,"created":1554951590000,"modified":1554951594000,"deprecated":false,"name":"Glycoprotein endo-alpha-1,2-mannosidase","accession":"Q5SRI9","gene":"MANEA","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.435828152858046,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":24.577438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.69054464600796,"pubTatorScore":1.9469432706978254,"self":"https://pharos.nih.gov/idg/api/v1/targets(12369)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(12369)/properties"},"_links":{"count":929,"href":"https://pharos.nih.gov/idg/api/v1/targets(12369)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12369)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12369)/publications"},"_namespace":null},{"id":12370,"version":2,"created":1554951595000,"modified":1554951599000,"deprecated":false,"name":"Acyl-CoA-binding protein","accession":"P07108","gene":"DBI","description":"Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3737356151381865,"antibodyCount":232,"monoclonalCount":38,"pubmedCount":null,"jensenScore":248.359455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.704114473761905,"pubTatorScore":2.3812530416456896,"self":"https://pharos.nih.gov/idg/api/v1/targets(12370)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(12370)/properties"},"_links":{"count":1194,"href":"https://pharos.nih.gov/idg/api/v1/targets(12370)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12370)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12370)/publications"},"_namespace":null},{"id":12371,"version":2,"created":1554951600000,"modified":1554951613000,"deprecated":false,"name":"Tyrosine-protein kinase Fgr","accession":"P09769","gene":"FGR","description":"Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.3797660575424056,"antibodyCount":400,"monoclonalCount":74,"pubmedCount":null,"jensenScore":226.919108,"patentCount":52062,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.278045090193615,"pubTatorScore":2.1525084086357897,"self":"https://pharos.nih.gov/idg/api/v1/targets(12371)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(12371)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(12371)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12371)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12371)/publications"},"_namespace":null},{"id":12372,"version":3,"created":1554951614000,"modified":1555040675000,"deprecated":false,"name":"28S ribosomal protein S24, mitochondrial","accession":"Q96EL2","gene":"MRPS24","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":88,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":27.10585604481022,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12372)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(12372)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(12372)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12372)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12372)/publications"},"_namespace":null},{"id":12373,"version":2,"created":1554951618000,"modified":1554951621000,"deprecated":false,"name":"JNK1/MAPK8-associated membrane protein","accession":"Q9P055","gene":"JKAMP","description":"May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1227618428326358,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.088827,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.852179537227812,"pubTatorScore":0.40815920617331186,"self":"https://pharos.nih.gov/idg/api/v1/targets(12373)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(12373)/properties"},"_links":{"count":929,"href":"https://pharos.nih.gov/idg/api/v1/targets(12373)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12373)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12373)/publications"},"_namespace":null},{"id":12374,"version":3,"created":1554951622000,"modified":1555040675000,"deprecated":false,"name":"Aminoacylase-1","accession":"Q03154","gene":"ACY1","description":"Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.004092908130308,"antibodyCount":313,"monoclonalCount":141,"pubmedCount":null,"jensenScore":100.297122,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.542489315288343,"pubTatorScore":2.170080826355854,"self":"https://pharos.nih.gov/idg/api/v1/targets(12374)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(12374)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(12374)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12374)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12374)/publications"},"_namespace":null},{"id":12375,"version":2,"created":1554951625000,"modified":1554951627000,"deprecated":false,"name":"PAK4-inhibitor INKA1","accession":"Q96EL1","gene":"FAM212A","description":"Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2798406965940431,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.178572,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.123486014106295,"pubTatorScore":-0.1760916933503803,"self":"https://pharos.nih.gov/idg/api/v1/targets(12375)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(12375)/properties"},"_links":{"count":757,"href":"https://pharos.nih.gov/idg/api/v1/targets(12375)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12375)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12375)/publications"},"_namespace":null},{"id":12376,"version":3,"created":1554951628000,"modified":1555040677000,"deprecated":false,"name":"39S ribosomal protein L53, mitochondrial","accession":"Q96EL3","gene":"MRPL53","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.15490196042003768,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.866667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":26.85022790905195,"pubTatorScore":-0.4357281747484515,"self":"https://pharos.nih.gov/idg/api/v1/targets(12376)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12376)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(12376)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12376)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12376)/publications"},"_namespace":null},{"id":12377,"version":2,"created":1554951631000,"modified":1554951632000,"deprecated":false,"name":"Keratin-associated protein 24-1","accession":"Q3LI83","gene":"KRTAP24-1","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.24303804977203064,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.3,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.791508803036828,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(12377)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12377)/properties"},"_links":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12377)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12377)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12377)/publications"},"_namespace":null},{"id":12378,"version":2,"created":1554951632000,"modified":1554951635000,"deprecated":false,"name":"Protein KTI12 homolog","accession":"Q96EK9","gene":"KTI12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.1241625068379677,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.941236,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.722569050313812,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(12378)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12378)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(12378)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(12378)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12378)/publications"},"_namespace":null},{"id":12379,"version":3,"created":1554951635000,"modified":1555040679000,"deprecated":false,"name":"Nuclear receptor subfamily 4 group A member 1","accession":"P22736","gene":"NR4A1","description":"Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.","idgFamily":"Nuclear Receptor","idgTDL":"Tbio","novelty":-2.888757655283649,"antibodyCount":494,"monoclonalCount":39,"pubmedCount":null,"jensenScore":811.956678,"patentCount":67519,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":50.41769671804386,"pubTatorScore":3.305082574956561,"self":"https://pharos.nih.gov/idg/api/v1/targets(12379)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":586,"href":"https://pharos.nih.gov/idg/api/v1/targets(12379)/properties"},"_links":{"count":1150,"href":"https://pharos.nih.gov/idg/api/v1/targets(12379)/links"},"_synonyms":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(12379)/synonyms"},"_publications":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(12379)/publications"},"_namespace":null},{"id":12380,"version":2,"created":1554951642000,"modified":1554951643000,"deprecated":false,"name":"Keratin-associated protein 27-1","accession":"Q3LI81","gene":"KRTAP27-1","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.005688085704007,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12380)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12380)/properties"},"_links":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(12380)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12380)/synonyms"},"_publications":null,"_namespace":null},{"id":12381,"version":3,"created":1554951643000,"modified":1555040681000,"deprecated":false,"name":"Protein-glutamine gamma-glutamyltransferase K","accession":"P22735","gene":"TGM1","description":"Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.5893982064270697,"antibodyCount":157,"monoclonalCount":14,"pubmedCount":null,"jensenScore":389.825533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.50706758845656,"pubTatorScore":2.7181691843381848,"self":"https://pharos.nih.gov/idg/api/v1/targets(12381)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(12381)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(12381)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12381)/synonyms"},"_publications":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12381)/publications"},"_namespace":null},{"id":12382,"version":2,"created":1554951650000,"modified":1554951650000,"deprecated":false,"name":"Myocilin opposite strand protein","accession":"A0A1B0GUC4","gene":"MYOCOS","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12382)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(12382)/properties"},"_links":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12382)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12382)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12382)/publications"},"_namespace":null},{"id":12383,"version":3,"created":1554951650000,"modified":1555040682000,"deprecated":false,"name":"KIF1-binding protein","accession":"Q96EK5","gene":"KIF1BP","description":"Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7361817316249424,"antibodyCount":53,"monoclonalCount":3,"pubmedCount":null,"jensenScore":48.300581,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":34.59261506211308,"pubTatorScore":2.085425791556253,"self":"https://pharos.nih.gov/idg/api/v1/targets(12383)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(12383)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(12383)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12383)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12383)/publications"},"_namespace":null},{"id":12384,"version":3,"created":1554951656000,"modified":1555040683000,"deprecated":false,"name":"THAP domain-containing protein 11","accession":"Q96EK4","gene":"THAP11","description":"Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1408964836977589,"antibodyCount":206,"monoclonalCount":59,"pubmedCount":null,"jensenScore":15.158589,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.927715193867233,"pubTatorScore":1.280843805228678,"self":"https://pharos.nih.gov/idg/api/v1/targets(12384)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(12384)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(12384)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12384)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12384)/publications"},"_namespace":null},{"id":12385,"version":2,"created":1554951659000,"modified":1554951662000,"deprecated":false,"name":"Constitutive coactivator of peroxisome proliferator-activated receptor gamma","accession":"Q96EK7","gene":"FAM120B","description":"Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2290947721420682,"antibodyCount":74,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.375964,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.67662006475544,"pubTatorScore":0.31587340514547607,"self":"https://pharos.nih.gov/idg/api/v1/targets(12385)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(12385)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(12385)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12385)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12385)/publications"},"_namespace":null},{"id":12386,"version":2,"created":1554951663000,"modified":1554951666000,"deprecated":false,"name":"Glucosamine 6-phosphate N-acetyltransferase","accession":"Q96EK6","gene":"GNPNAT1","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4505789612139761,"antibodyCount":58,"monoclonalCount":11,"pubmedCount":null,"jensenScore":29.394751,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.1239618540629,"pubTatorScore":-0.405765504109289,"self":"https://pharos.nih.gov/idg/api/v1/targets(12386)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(12386)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(12386)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12386)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12386)/publications"},"_namespace":null},{"id":12387,"version":2,"created":1554951667000,"modified":1554951668000,"deprecated":false,"name":"Protein FAM177B","accession":"A6PVY3","gene":"FAM177B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.341998789701066,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12387)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(12387)/properties"},"_links":{"count":655,"href":"https://pharos.nih.gov/idg/api/v1/targets(12387)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12387)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12387)/publications"},"_namespace":null},{"id":12388,"version":3,"created":1554951669000,"modified":1555040685000,"deprecated":false,"name":"Solute carrier family 2, facilitated glucose transporter member 5","accession":"P22732","gene":"SLC2A5","description":"Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.3318993574799327,"antibodyCount":261,"monoclonalCount":110,"pubmedCount":null,"jensenScore":207.433868,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":39.225237553533326,"pubTatorScore":2.0551827095326414,"self":"https://pharos.nih.gov/idg/api/v1/targets(12388)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12388)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(12388)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12388)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12388)/publications"},"_namespace":null},{"id":12389,"version":2,"created":1554951675000,"modified":1554951677000,"deprecated":false,"name":"Fibroblast growth factor 6","accession":"P10767","gene":"FGF6","description":"Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5613654228716891,"antibodyCount":113,"monoclonalCount":23,"pubmedCount":null,"jensenScore":40.19574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.53567751935458,"pubTatorScore":1.5587848053177944,"self":"https://pharos.nih.gov/idg/api/v1/targets(12389)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(12389)/properties"},"_links":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12389)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12389)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12389)/publications"},"_namespace":null},{"id":12390,"version":2,"created":1554951677000,"modified":1554951680000,"deprecated":false,"name":"S-formylglutathione hydrolase","accession":"P10768","gene":"ESD","description":"Serine hydrolase involved in the detoxification of formaldehyde.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.3260874460577368,"antibodyCount":140,"monoclonalCount":16,"pubmedCount":null,"jensenScore":210.303728,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.234424527006745,"pubTatorScore":2.4578659001781786,"self":"https://pharos.nih.gov/idg/api/v1/targets(12390)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(12390)/properties"},"_links":{"count":1079,"href":"https://pharos.nih.gov/idg/api/v1/targets(12390)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12390)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12390)/publications"},"_namespace":null},{"id":12391,"version":2,"created":1554951682000,"modified":1554951684000,"deprecated":false,"name":"Arrestin domain-containing protein 2","accession":"Q8TBH0","gene":"ARRDC2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.48139106281804,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12391)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(12391)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(12391)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12391)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12391)/publications"},"_namespace":null},{"id":12392,"version":2,"created":1554951685000,"modified":1554951685000,"deprecated":false,"name":"Keratin-associated protein 6-3","accession":"Q3LI67","gene":"KRTAP6-3","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4393326981732075,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.645833,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.305673395006394,"pubTatorScore":0.03778852469819142,"self":"https://pharos.nih.gov/idg/api/v1/targets(12392)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12392)/properties"},"_links":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12392)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12392)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12392)/publications"},"_namespace":null},{"id":12393,"version":2,"created":1554951685000,"modified":1554951689000,"deprecated":false,"name":"Bromodomain and WD repeat-containing protein 3","accession":"Q6RI45","gene":"BRWD3","description":"Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.7743431374566901,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.778327,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.608717875175405,"pubTatorScore":0.8259204386795331,"self":"https://pharos.nih.gov/idg/api/v1/targets(12393)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(12393)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(12393)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12393)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12393)/publications"},"_namespace":null},{"id":12394,"version":2,"created":1554951689000,"modified":1554951692000,"deprecated":false,"name":"PHD finger protein 21B","accession":"Q96EK2","gene":"PHF21B","description":null,"idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.4648868019217715,"antibodyCount":54,"monoclonalCount":34,"pubmedCount":null,"jensenScore":3.823077,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.8769728479662,"pubTatorScore":0.3679767232525211,"self":"https://pharos.nih.gov/idg/api/v1/targets(12394)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12394)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(12394)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12394)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12394)/publications"},"_namespace":null},{"id":12395,"version":2,"created":1554951693000,"modified":1554951693000,"deprecated":false,"name":"Keratin-associated protein 22-2","accession":"Q3LI68","gene":"KRTAP22-2","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.855862984719055,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12395)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12395)/properties"},"_links":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12395)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12395)/synonyms"},"_publications":null,"_namespace":null},{"id":12396,"version":2,"created":1554951693000,"modified":1554951696000,"deprecated":false,"name":"Myosin regulatory light chain 12A","accession":"P19105","gene":"MYL12A","description":"Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.531565523996947,"antibodyCount":93,"monoclonalCount":11,"pubmedCount":null,"jensenScore":32.882041,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.7668464045529908,"self":"https://pharos.nih.gov/idg/api/v1/targets(12396)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(12396)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(12396)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12396)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12396)/publications"},"_namespace":null},{"id":12397,"version":4,"created":1554951697000,"modified":1555040686000,"deprecated":false,"name":"Carbonic anhydrase 4","accession":"P22748","gene":"CA4","description":"Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.19547212627471,"antibodyCount":186,"monoclonalCount":29,"pubmedCount":null,"jensenScore":1475.676287,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.88170830729562,"pubTatorScore":2.6238669781275235,"self":"https://pharos.nih.gov/idg/api/v1/targets(12397)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(12397)/properties"},"_links":{"count":1311,"href":"https://pharos.nih.gov/idg/api/v1/targets(12397)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12397)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12397)/publications"},"_namespace":null},{"id":12398,"version":2,"created":1554951726000,"modified":1554951726000,"deprecated":false,"name":"Keratin-associated protein 19-5","accession":"Q3LI72","gene":"KRTAP19-5","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.3520030858370085,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12398)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12398)/properties"},"_links":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12398)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12398)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12398)/publications"},"_namespace":null},{"id":12399,"version":2,"created":1554951726000,"modified":1554951726000,"deprecated":false,"name":"Keratin-associated protein 19-4","accession":"Q3LI73","gene":"KRTAP19-4","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.3935052371273215,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12399)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12399)/properties"},"_links":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12399)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12399)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12399)/publications"},"_namespace":null},{"id":12400,"version":2,"created":1554951726000,"modified":1554951727000,"deprecated":false,"name":"Keratin-associated protein 19-6","accession":"Q3LI70","gene":"KRTAP19-6","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.025770510918133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12400)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12400)/properties"},"_links":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12400)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12400)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12400)/publications"},"_namespace":null},{"id":12401,"version":3,"created":1554951727000,"modified":1555040688000,"deprecated":false,"name":"Synaptoporin","accession":"Q8TBG9","gene":"SYNPR","description":"Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2042368062109134,"antibodyCount":120,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.759819,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.94311112212178,"pubTatorScore":0.649098853897034,"self":"https://pharos.nih.gov/idg/api/v1/targets(12401)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(12401)/properties"},"_links":{"count":681,"href":"https://pharos.nih.gov/idg/api/v1/targets(12401)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12401)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12401)/publications"},"_namespace":null},{"id":12402,"version":2,"created":1554951731000,"modified":1554951732000,"deprecated":false,"name":"Keratin-associated protein 15-1","accession":"Q3LI76","gene":"KRTAP15-1","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.177030811637232,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12402)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12402)/properties"},"_links":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12402)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12402)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12402)/publications"},"_namespace":null},{"id":12403,"version":2,"created":1554951732000,"modified":1554951734000,"deprecated":false,"name":"Keratin-associated protein 13-4","accession":"Q3LI77","gene":"KRTAP13-4","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.114826834287589,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12403)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12403)/properties"},"_links":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12403)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(12403)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12403)/publications"},"_namespace":null},{"id":12404,"version":3,"created":1554951734000,"modified":1555040689000,"deprecated":false,"name":"Ethanolamine-phosphate phospho-lyase","accession":"Q8TBG4","gene":"ETNPPL","description":"Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5714008726241447,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.281351,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.24818686391922,"pubTatorScore":0.561529501463565,"self":"https://pharos.nih.gov/idg/api/v1/targets(12404)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(12404)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(12404)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12404)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12404)/publications"},"_namespace":null},{"id":12405,"version":2,"created":1554951738000,"modified":1554951742000,"deprecated":false,"name":"Granulysin","accession":"P22749","gene":"GNLY","description":"Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5879546247904206,"antibodyCount":199,"monoclonalCount":66,"pubmedCount":null,"jensenScore":381.449279,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.637092609375408,"pubTatorScore":2.316947800349024,"self":"https://pharos.nih.gov/idg/api/v1/targets(12405)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(12405)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(12405)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12405)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12405)/publications"},"_namespace":null},{"id":12406,"version":2,"created":1554951743000,"modified":1554951744000,"deprecated":false,"name":"Putative ubiquitin-conjugating enzyme E2 N-like","accession":"Q5JXB2","gene":"UBE2NL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4736607226101559,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.564102,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.41774257493885,"pubTatorScore":0.06694691371473312,"self":"https://pharos.nih.gov/idg/api/v1/targets(12406)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12406)/properties"},"_links":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(12406)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12406)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12406)/publications"},"_namespace":null},{"id":12407,"version":3,"created":1554951744000,"modified":1555040690000,"deprecated":false,"name":"Caveolin-1","accession":"Q03135","gene":"CAV1","description":"May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.356853411556107,"antibodyCount":855,"monoclonalCount":190,"pubmedCount":null,"jensenScore":2432.323762,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":59.70144540295783,"pubTatorScore":3.383216650016751,"self":"https://pharos.nih.gov/idg/api/v1/targets(12407)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1349,"href":"https://pharos.nih.gov/idg/api/v1/targets(12407)/properties"},"_links":{"count":1987,"href":"https://pharos.nih.gov/idg/api/v1/targets(12407)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12407)/synonyms"},"_publications":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(12407)/publications"},"_namespace":null},{"id":12408,"version":3,"created":1554951758000,"modified":1555040695000,"deprecated":false,"name":"Phosphatidylinositol-glycan biosynthesis class X protein","accession":"Q8TBF5","gene":"PIGX","description":"Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":105,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.384615,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.366990068660293,"pubTatorScore":0.21559976257461566,"self":"https://pharos.nih.gov/idg/api/v1/targets(12408)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(12408)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(12408)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12408)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12408)/publications"},"_namespace":null},{"id":12409,"version":2,"created":1554951761000,"modified":1554951764000,"deprecated":false,"name":"Protein FAM81A","accession":"Q8TBF8","gene":"FAM81A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.3424226808222062,"antibodyCount":55,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.04,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.857525154923586,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12409)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(12409)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(12409)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12409)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12409)/publications"},"_namespace":null},{"id":12410,"version":3,"created":1554951765000,"modified":1555040696000,"deprecated":false,"name":"Prostamide/prostaglandin F synthase","accession":"Q8TBF2","gene":"FAM213B","description":"Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.1303337689293006,"antibodyCount":60,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.757576,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":27.212744261535647,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12410)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(12410)/properties"},"_links":{"count":1172,"href":"https://pharos.nih.gov/idg/api/v1/targets(12410)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12410)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12410)/publications"},"_namespace":null},{"id":12411,"version":2,"created":1554951769000,"modified":1554951771000,"deprecated":false,"name":"Transcription elongation factor A protein-like 4","accession":"Q96EI5","gene":"TCEAL4","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.03218468270325591,"antibodyCount":57,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.586854647475686,"pubTatorScore":0.31627005207473957,"self":"https://pharos.nih.gov/idg/api/v1/targets(12411)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(12411)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(12411)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12411)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12411)/publications"},"_namespace":null},{"id":12412,"version":3,"created":1554951772000,"modified":1555040699000,"deprecated":false,"name":"Zinc finger CCHC-type and RNA-binding motif-containing protein 1","accession":"Q8TBF4","gene":"ZCRB1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4149733531823518,"antibodyCount":108,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.969298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":47,"knowledgeAvailability":30.06484985179704,"pubTatorScore":0.43933269383026263,"self":"https://pharos.nih.gov/idg/api/v1/targets(12412)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(12412)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(12412)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12412)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12412)/publications"},"_namespace":null},{"id":12413,"version":2,"created":1554951775000,"modified":1554951779000,"deprecated":false,"name":"Tumor-associated calcium signal transducer 2","accession":"P09758","gene":"TACSTD2","description":"May function as a growth factor receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8583652596804314,"antibodyCount":440,"monoclonalCount":123,"pubmedCount":null,"jensenScore":711.102654,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.06689402186885,"pubTatorScore":2.4722869601936477,"self":"https://pharos.nih.gov/idg/api/v1/targets(12413)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(12413)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(12413)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12413)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12413)/publications"},"_namespace":null},{"id":12414,"version":2,"created":1554951780000,"modified":1554951782000,"deprecated":false,"name":"Retinol-binding protein 3","accession":"P10745","gene":"RBP3","description":"IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.6754870798820005,"antibodyCount":145,"monoclonalCount":9,"pubmedCount":null,"jensenScore":501.994816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.348310292236267,"pubTatorScore":2.3424696768385456,"self":"https://pharos.nih.gov/idg/api/v1/targets(12414)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(12414)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(12414)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12414)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12414)/publications"},"_namespace":null},{"id":12415,"version":2,"created":1554951783000,"modified":1554951785000,"deprecated":false,"name":"SAM and SH3 domain-containing protein 3","accession":"O75995","gene":"SASH3","description":"May function as a signaling adapter protein in lymphocytes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.065004809749077,"pubTatorScore":1.2090679705790577,"self":"https://pharos.nih.gov/idg/api/v1/targets(12415)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(12415)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(12415)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12415)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12415)/publications"},"_namespace":null},{"id":12416,"version":2,"created":1554951786000,"modified":1554951788000,"deprecated":false,"name":"Mediator of RNA polymerase II transcription subunit 11","accession":"Q9P086","gene":"MED11","description":"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7961556646512017,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.461694,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.008956072240327,"pubTatorScore":1.007348068791654,"self":"https://pharos.nih.gov/idg/api/v1/targets(12416)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12416)/properties"},"_links":{"count":838,"href":"https://pharos.nih.gov/idg/api/v1/targets(12416)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12416)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12416)/publications"},"_namespace":null},{"id":12417,"version":3,"created":1554951788000,"modified":1555040700000,"deprecated":false,"name":"Uroporphyrinogen-III synthase","accession":"P10746","gene":"UROS","description":"Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4898157112112242,"antibodyCount":67,"monoclonalCount":23,"pubmedCount":null,"jensenScore":310.918988,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":38.0137546640072,"pubTatorScore":2.110000144390718,"self":"https://pharos.nih.gov/idg/api/v1/targets(12417)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(12417)/properties"},"_links":{"count":1061,"href":"https://pharos.nih.gov/idg/api/v1/targets(12417)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12417)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12417)/publications"},"_namespace":null},{"id":12418,"version":2,"created":1554951794000,"modified":1554951796000,"deprecated":false,"name":"Migration and invasion-inhibitory protein","accession":"Q5JXC2","gene":"MIIP","description":"Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1483136845575725,"antibodyCount":96,"monoclonalCount":1,"pubmedCount":null,"jensenScore":16.089574,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.824505542704017,"pubTatorScore":1.042378598139876,"self":"https://pharos.nih.gov/idg/api/v1/targets(12418)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(12418)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(12418)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12418)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12418)/publications"},"_namespace":null},{"id":12419,"version":3,"created":1554951797000,"modified":1555040702000,"deprecated":false,"name":"T-cell-specific surface glycoprotein CD28","accession":"P10747","gene":"CD28","description":"Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9686549675745884,"antibodyCount":1508,"monoclonalCount":1184,"pubmedCount":null,"jensenScore":108.846505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":40.34033610091161,"pubTatorScore":3.26564014839779,"self":"https://pharos.nih.gov/idg/api/v1/targets(12419)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":640,"href":"https://pharos.nih.gov/idg/api/v1/targets(12419)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(12419)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(12419)/synonyms"},"_publications":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(12419)/publications"},"_namespace":null},{"id":12420,"version":2,"created":1554951805000,"modified":1554951808000,"deprecated":false,"name":"60S ribosomal protein L39-like","accession":"Q96EH5","gene":"RPL39L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.41820919122208955,"antibodyCount":71,"monoclonalCount":32,"pubmedCount":null,"jensenScore":2.134956,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.308713121256293,"pubTatorScore":0.49019271039162143,"self":"https://pharos.nih.gov/idg/api/v1/targets(12420)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(12420)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(12420)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12420)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12420)/publications"},"_namespace":null},{"id":12421,"version":2,"created":1554951809000,"modified":1554951811000,"deprecated":false,"name":"E3 ubiquitin-protein ligase NEURL3","accession":"Q96EH8","gene":"NEURL3","description":"E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.240220237981541,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12421)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(12421)/properties"},"_links":{"count":655,"href":"https://pharos.nih.gov/idg/api/v1/targets(12421)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(12421)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12421)/publications"},"_namespace":null},{"id":12422,"version":3,"created":1554951811000,"modified":1555040704000,"deprecated":false,"name":"Solute carrier family 35 member G2","accession":"Q8TBE7","gene":"SLC35G2","description":"May play a role in cell proliferation.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":0.11270428143212972,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.883242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.07812629964172,"pubTatorScore":0.09874856672961273,"self":"https://pharos.nih.gov/idg/api/v1/targets(12422)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(12422)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(12422)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12422)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12422)/publications"},"_namespace":null},{"id":12423,"version":2,"created":1554951815000,"modified":1554951817000,"deprecated":false,"name":"Bromo adjacent homology domain-containing 1 protein","accession":"Q8TBE0","gene":"BAHD1","description":"Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.708515330928139,"antibodyCount":66,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.492756,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.077115342914695,"pubTatorScore":0.308208509095282,"self":"https://pharos.nih.gov/idg/api/v1/targets(12423)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12423)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(12423)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12423)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12423)/publications"},"_namespace":null},{"id":12424,"version":3,"created":1554951818000,"modified":1555040705000,"deprecated":false,"name":"1,4-alpha-glucan-branching enzyme","accession":"Q04446","gene":"GBE1","description":"Required for normal glycogen accumulation (PubMed:8463281, PubMed:26199317, PubMed:8613547). The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4523015796625565,"antibodyCount":230,"monoclonalCount":57,"pubmedCount":null,"jensenScore":289.293008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":46.894612932432665,"pubTatorScore":2.0124463778080233,"self":"https://pharos.nih.gov/idg/api/v1/targets(12424)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(12424)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12424)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12424)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(12424)/publications"},"_namespace":null},{"id":12425,"version":3,"created":1554951824000,"modified":1555040706000,"deprecated":false,"name":"Protein cornichon homolog 3","accession":"Q8TBE1","gene":"CNIH3","description":"Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5096504802704066,"antibodyCount":92,"monoclonalCount":18,"pubmedCount":null,"jensenScore":3.608073,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.958462906837006,"pubTatorScore":0.014240299019593509,"self":"https://pharos.nih.gov/idg/api/v1/targets(12425)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12425)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(12425)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12425)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12425)/publications"},"_namespace":null},{"id":12426,"version":2,"created":1554951828000,"modified":1554951831000,"deprecated":false,"name":"Fibronectin type III domain-containing protein 9","accession":"Q8TBE3","gene":"FNDC9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":30,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.083333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.368475096757365,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12426)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(12426)/properties"},"_links":{"count":733,"href":"https://pharos.nih.gov/idg/api/v1/targets(12426)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(12426)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12426)/publications"},"_namespace":null},{"id":12427,"version":2,"created":1554951831000,"modified":1554951834000,"deprecated":false,"name":"Mitochondrial assembly of ribosomal large subunit protein 1","accession":"Q96EH3","gene":"MALSU1","description":"May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6020599913279624,"antibodyCount":45,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.641880520555596,"pubTatorScore":0.7781512503836436,"self":"https://pharos.nih.gov/idg/api/v1/targets(12427)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(12427)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(12427)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12427)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12427)/publications"},"_namespace":null},{"id":12428,"version":3,"created":1554951834000,"modified":1555040708000,"deprecated":false,"name":"Tyrosine 3-monooxygenase","accession":"P07101","gene":"TH","description":"Plays an important role in the physiology of adrenergic neurons.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.4979007731847127,"antibodyCount":1203,"monoclonalCount":249,"pubmedCount":null,"jensenScore":2144.647951,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":46.06551439317565,"pubTatorScore":3.034128221104905,"self":"https://pharos.nih.gov/idg/api/v1/targets(12428)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(12428)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(12428)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(12428)/synonyms"},"_publications":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12428)/publications"},"_namespace":null},{"id":12429,"version":2,"created":1554951845000,"modified":1554951848000,"deprecated":false,"name":"N-acylneuraminate-9-phosphatase","accession":"Q8TBE9","gene":"NANP","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.367839425198129,"antibodyCount":207,"monoclonalCount":87,"pubmedCount":null,"jensenScore":234.672862,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.16343011839022,"pubTatorScore":0.9395192526186185,"self":"https://pharos.nih.gov/idg/api/v1/targets(12429)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(12429)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(12429)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12429)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12429)/publications"},"_namespace":null},{"id":12430,"version":3,"created":1554951848000,"modified":1555040710000,"deprecated":false,"name":"Diamine acetyltransferase 2","accession":"Q96F10","gene":"SAT2","description":"Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0246224702034752,"antibodyCount":55,"monoclonalCount":18,"pubmedCount":null,"jensenScore":10.210291,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.17114235194678,"pubTatorScore":1.9138432615984027,"self":"https://pharos.nih.gov/idg/api/v1/targets(12430)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(12430)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(12430)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12430)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12430)/publications"},"_namespace":null},{"id":12431,"version":3,"created":1554951852000,"modified":1555040711000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF31","accession":"Q96EP0","gene":"RNF31","description":"E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.755578385871821,"antibodyCount":174,"monoclonalCount":3,"pubmedCount":null,"jensenScore":57.33829,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":35.168373308822225,"pubTatorScore":1.390121685512057,"self":"https://pharos.nih.gov/idg/api/v1/targets(12431)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(12431)/properties"},"_links":{"count":1087,"href":"https://pharos.nih.gov/idg/api/v1/targets(12431)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(12431)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12431)/publications"},"_namespace":null},{"id":12432,"version":2,"created":1554951856000,"modified":1554951858000,"deprecated":false,"name":"Transcription factor AP-2-epsilon","accession":"Q6VUC0","gene":"TFAP2E","description":"Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0747386135357093,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.282877,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.68248800854297,"pubTatorScore":0.8477488704537544,"self":"https://pharos.nih.gov/idg/api/v1/targets(12432)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(12432)/properties"},"_links":{"count":759,"href":"https://pharos.nih.gov/idg/api/v1/targets(12432)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12432)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12432)/publications"},"_namespace":null},{"id":12433,"version":2,"created":1554951859000,"modified":1554951862000,"deprecated":false,"name":"DAZ-associated protein 1","accession":"Q96EP5","gene":"DAZAP1","description":"RNA-binding protein, which may be required during spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3651981882964876,"antibodyCount":143,"monoclonalCount":30,"pubmedCount":null,"jensenScore":25.223946,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.478907307124466,"pubTatorScore":1.1211219478871626,"self":"https://pharos.nih.gov/idg/api/v1/targets(12433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(12433)/properties"},"_links":{"count":1121,"href":"https://pharos.nih.gov/idg/api/v1/targets(12433)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12433)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12433)/publications"},"_namespace":null},{"id":12434,"version":2,"created":1554951863000,"modified":1554951866000,"deprecated":false,"name":"GTPase IMAP family member 5","accession":"Q96F15","gene":"GIMAP5","description":"Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5536085541606575,"antibodyCount":133,"monoclonalCount":23,"pubmedCount":null,"jensenScore":40.847412,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.13873396521352,"pubTatorScore":1.1480196057369316,"self":"https://pharos.nih.gov/idg/api/v1/targets(12434)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12434)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(12434)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12434)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12434)/publications"},"_namespace":null},{"id":12435,"version":2,"created":1554951866000,"modified":1554951870000,"deprecated":false,"name":"Protein ENL","accession":"Q03111","gene":"MLLT1","description":"Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.469307356364799,"antibodyCount":119,"monoclonalCount":14,"pubmedCount":null,"jensenScore":301.216243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.92963158449154,"pubTatorScore":2.0785707637161766,"self":"https://pharos.nih.gov/idg/api/v1/targets(12435)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(12435)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(12435)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12435)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12435)/publications"},"_namespace":null},{"id":12436,"version":3,"created":1554951871000,"modified":1555040713000,"deprecated":false,"name":"MDS1 and EVI1 complex locus protein EVI1","accession":"Q03112","gene":"MECOM","description":"Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-1.8405952464351278,"antibodyCount":317,"monoclonalCount":77,"pubmedCount":null,"jensenScore":124.51994,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":0.0,"pubTatorScore":2.365201894660987,"self":"https://pharos.nih.gov/idg/api/v1/targets(12436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":600,"href":"https://pharos.nih.gov/idg/api/v1/targets(12436)/properties"},"_links":{"count":1137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12436)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(12436)/synonyms"},"_publications":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(12436)/publications"},"_namespace":null},{"id":12437,"version":3,"created":1554951878000,"modified":1555040715000,"deprecated":false,"name":"Spliceosome-associated protein CWC15 homolog","accession":"Q9P013","gene":"CWC15","description":"Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":57,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.79888880658704,"pubTatorScore":2.1841447728424916,"self":"https://pharos.nih.gov/idg/api/v1/targets(12437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12437)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(12437)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12437)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12437)/publications"},"_namespace":null},{"id":12438,"version":2,"created":1554951881000,"modified":1554951884000,"deprecated":false,"name":"Transmembrane protein 254","accession":"Q8TBM7","gene":"TMEM254","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8081144738575967,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.111406,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.362742832402187,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(12438)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(12438)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(12438)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12438)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12438)/publications"},"_namespace":null},{"id":12439,"version":2,"created":1554951884000,"modified":1554951888000,"deprecated":false,"name":"Guanine nucleotide-binding protein subunit alpha-12","accession":"Q03113","gene":"GNA12","description":"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9732510717364119,"antibodyCount":163,"monoclonalCount":3,"pubmedCount":null,"jensenScore":9.107809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.23606958355256,"pubTatorScore":1.8557964280667698,"self":"https://pharos.nih.gov/idg/api/v1/targets(12439)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(12439)/properties"},"_links":{"count":1094,"href":"https://pharos.nih.gov/idg/api/v1/targets(12439)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12439)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12439)/publications"},"_namespace":null},{"id":12440,"version":2,"created":1554951889000,"modified":1554951892000,"deprecated":false,"name":"39S ribosomal protein L15, mitochondrial","accession":"Q9P015","gene":"MRPL15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":103,"monoclonalCount":20,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.16111576799065,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(12440)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12440)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(12440)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12440)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12440)/publications"},"_namespace":null},{"id":12441,"version":3,"created":1554951893000,"modified":1555040716000,"deprecated":false,"name":"Thymocyte nuclear protein 1","accession":"Q9P016","gene":"THYN1","description":"Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9256690120844794,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.5777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.180870687904434,"pubTatorScore":0.8061799739838872,"self":"https://pharos.nih.gov/idg/api/v1/targets(12441)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(12441)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12441)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12441)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12441)/publications"},"_namespace":null},{"id":12442,"version":2,"created":1554951897000,"modified":1554951901000,"deprecated":false,"name":"E3 ubiquitin-protein ligase CHFR","accession":"Q96EP1","gene":"CHFR","description":"E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9774038000365666,"antibodyCount":220,"monoclonalCount":23,"pubmedCount":null,"jensenScore":107.673478,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.950156426037026,"pubTatorScore":2.0668682757409047,"self":"https://pharos.nih.gov/idg/api/v1/targets(12442)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(12442)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(12442)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12442)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12442)/publications"},"_namespace":null},{"id":12443,"version":3,"created":1554951902000,"modified":1555040718000,"deprecated":false,"name":"Histone-lysine N-methyltransferase EHMT1","accession":"Q9H9B1","gene":"EHMT1","description":"Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.3494341145114643,"antibodyCount":425,"monoclonalCount":86,"pubmedCount":null,"jensenScore":219.787361,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.46598957734572,"pubTatorScore":1.8091672516092794,"self":"https://pharos.nih.gov/idg/api/v1/targets(12443)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(12443)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(12443)/links"},"_synonyms":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(12443)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12443)/publications"},"_namespace":null},{"id":12444,"version":3,"created":1554951911000,"modified":1555040719000,"deprecated":false,"name":"Sideroflexin-1","accession":"Q9H9B4","gene":"SFXN1","description":"Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5926085006057281,"antibodyCount":117,"monoclonalCount":6,"pubmedCount":null,"jensenScore":3.726556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.77285524277827,"pubTatorScore":1.095169316548663,"self":"https://pharos.nih.gov/idg/api/v1/targets(12444)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(12444)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(12444)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12444)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12444)/publications"},"_namespace":null},{"id":12445,"version":3,"created":1554951916000,"modified":1555040721000,"deprecated":false,"name":"Carboxypeptidase D","accession":"O75976","gene":"CPD","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5816179904518548,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":36.702947,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":44.11203921836799,"pubTatorScore":1.7643951230463764,"self":"https://pharos.nih.gov/idg/api/v1/targets(12445)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(12445)/properties"},"_links":{"count":1065,"href":"https://pharos.nih.gov/idg/api/v1/targets(12445)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12445)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12445)/publications"},"_namespace":null},{"id":12446,"version":2,"created":1554951922000,"modified":1554951924000,"deprecated":false,"name":"C1q-related factor","accession":"O75973","gene":"C1QL1","description":"May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7066104822951363,"antibodyCount":45,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.96923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.695331051841606,"pubTatorScore":2.424302147887364,"self":"https://pharos.nih.gov/idg/api/v1/targets(12446)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(12446)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(12446)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12446)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12446)/publications"},"_namespace":null},{"id":12447,"version":2,"created":1554951925000,"modified":1554951928000,"deprecated":false,"name":"Cysteine-rich PDZ-binding protein","accession":"Q9P021","gene":"CRIPT","description":"Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1763696224351552,"antibodyCount":64,"monoclonalCount":8,"pubmedCount":null,"jensenScore":13.743275,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.44824404681961,"pubTatorScore":0.9731744684524081,"self":"https://pharos.nih.gov/idg/api/v1/targets(12447)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(12447)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(12447)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12447)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12447)/publications"},"_namespace":null},{"id":12448,"version":3,"created":1554951929000,"modified":1555040724000,"deprecated":false,"name":"Uncharacterized protein C11orf24","accession":"Q96F05","gene":"C11orf24","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":57,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.916667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":0.0,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(12448)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(12448)/properties"},"_links":{"count":831,"href":"https://pharos.nih.gov/idg/api/v1/targets(12448)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12448)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12448)/publications"},"_namespace":null},{"id":12449,"version":2,"created":1554951933000,"modified":1554951935000,"deprecated":false,"name":"snRNA-activating protein complex subunit 5","accession":"O75971","gene":"SNAPC5","description":"Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.14903302534965282,"antibodyCount":98,"monoclonalCount":56,"pubmedCount":null,"jensenScore":0.746003,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.998961115936797,"pubTatorScore":0.054813687490517474,"self":"https://pharos.nih.gov/idg/api/v1/targets(12449)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(12449)/properties"},"_links":{"count":930,"href":"https://pharos.nih.gov/idg/api/v1/targets(12449)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12449)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12449)/publications"},"_namespace":null},{"id":12450,"version":2,"created":1554951936000,"modified":1554951940000,"deprecated":false,"name":"Cytoplasmic FMR1-interacting protein 2","accession":"Q96F07","gene":"CYFIP2","description":"Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5081286595403451,"antibodyCount":99,"monoclonalCount":19,"pubmedCount":null,"jensenScore":22.951942,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.37001014738242,"pubTatorScore":1.165144067631916,"self":"https://pharos.nih.gov/idg/api/v1/targets(12450)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(12450)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(12450)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12450)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12450)/publications"},"_namespace":null},{"id":12451,"version":2,"created":1554951941000,"modified":1554951946000,"deprecated":false,"name":"Multiple PDZ domain protein","accession":"O75970","gene":"MPDZ","description":"Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6369006396077068,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":47.312849,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.652705167539274,"pubTatorScore":1.5664267555013498,"self":"https://pharos.nih.gov/idg/api/v1/targets(12451)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12451)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(12451)/links"},"_synonyms":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(12451)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12451)/publications"},"_namespace":null},{"id":12452,"version":3,"created":1554951947000,"modified":1555040725000,"deprecated":false,"name":"CCR4-NOT transcription complex subunit 10","accession":"Q9H9A5","gene":"CNOT10","description":"Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.28879554286609027,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.694444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":30.657800079483128,"pubTatorScore":0.054357534588902724,"self":"https://pharos.nih.gov/idg/api/v1/targets(12452)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12452)/publications"},"_namespace":null},{"id":12453,"version":3,"created":1554951951000,"modified":1555040726000,"deprecated":false,"name":"Lys-63-specific deubiquitinase BRCC36","accession":"P46736","gene":"BRCC3","description":"Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1521529707047846,"antibodyCount":225,"monoclonalCount":59,"pubmedCount":null,"jensenScore":13.427387,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.26500891134578,"pubTatorScore":1.3270715100666506,"self":"https://pharos.nih.gov/idg/api/v1/targets(12453)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12453)/publications"},"_namespace":null},{"id":12454,"version":3,"created":1554951955000,"modified":1555040727000,"deprecated":false,"name":"RecQ-mediated genome instability protein 1","accession":"Q9H9A7","gene":"RMI1","description":"Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5950980668881543,"antibodyCount":118,"monoclonalCount":5,"pubmedCount":null,"jensenScore":41.287063,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.897298980911685,"pubTatorScore":1.5407092475299726,"self":"https://pharos.nih.gov/idg/api/v1/targets(12454)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12454)/publications"},"_namespace":null},{"id":12455,"version":3,"created":1554951960000,"modified":1555040728000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 40","accession":"Q9H9A6","gene":"LRRC40","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8287076237783628,"antibodyCount":87,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.102564,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.503458955088117,"pubTatorScore":-1.3010299956639813,"self":"https://pharos.nih.gov/idg/api/v1/targets(12455)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/properties"},"_links":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12455)/publications"},"_namespace":null},{"id":12456,"version":2,"created":1554951963000,"modified":1554951966000,"deprecated":false,"name":"Zinc finger CCHC domain-containing protein 10","accession":"Q8TBK6","gene":"ZCCHC10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5477023284263104,"antibodyCount":22,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.283333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.039608593222656,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12456)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/properties"},"_links":{"count":872,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12456)/publications"},"_namespace":null},{"id":12457,"version":2,"created":1554951967000,"modified":1554951970000,"deprecated":false,"name":"Molybdenum cofactor sulfurase","accession":"Q96EN8","gene":"MOCOS","description":"Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.104851267341045,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":13.074248,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.7301930491293,"pubTatorScore":1.119109174607437,"self":"https://pharos.nih.gov/idg/api/v1/targets(12457)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12457)/publications"},"_namespace":null},{"id":12458,"version":2,"created":1554951971000,"modified":1554951978000,"deprecated":false,"name":"Matrix Gla protein","accession":"P08493","gene":"MGP","description":"Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9742928026882014,"antibodyCount":151,"monoclonalCount":30,"pubmedCount":null,"jensenScore":878.140114,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.598997513401024,"pubTatorScore":2.540607958486806,"self":"https://pharos.nih.gov/idg/api/v1/targets(12458)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(12458)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12458)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12458)/synonyms"},"_publications":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12458)/publications"},"_namespace":null},{"id":12459,"version":2,"created":1554951979000,"modified":1554951982000,"deprecated":false,"name":"Uncharacterized protein C19orf60","accession":"Q96EN9","gene":"REX1BD","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12459)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12459)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(12459)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12459)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12459)/publications"},"_namespace":null},{"id":12460,"version":4,"created":1554951982000,"modified":1555040730000,"deprecated":false,"name":"Sphingosine 1-phosphate receptor 1","accession":"P21453","gene":"S1PR1","description":"G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.6622034179391076,"antibodyCount":526,"monoclonalCount":114,"pubmedCount":null,"jensenScore":474.362556,"patentCount":42469,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":42.03888251922993,"pubTatorScore":2.461222402409432,"self":"https://pharos.nih.gov/idg/api/v1/targets(12460)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":570,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/properties"},"_links":{"count":1954,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/synonyms"},"_publications":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(12460)/publications"},"_namespace":null},{"id":12461,"version":4,"created":1554952231000,"modified":1555040734000,"deprecated":false,"name":"Substance-K receptor","accession":"P21452","gene":"TACR2","description":"This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.565774515951548,"antibodyCount":189,"monoclonalCount":4,"pubmedCount":null,"jensenScore":318.325819,"patentCount":13616,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.37132924895475,"pubTatorScore":2.3657483917672932,"self":"https://pharos.nih.gov/idg/api/v1/targets(12461)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/properties"},"_links":{"count":1448,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12461)/publications"},"_namespace":null},{"id":12462,"version":2,"created":1554952373000,"modified":1554952378000,"deprecated":false,"name":"Dual specificity mitogen-activated protein kinase kinase 3","accession":"P46734","gene":"MAP2K3","description":"Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.3530133576641026,"antibodyCount":1060,"monoclonalCount":478,"pubmedCount":null,"jensenScore":190.893144,"patentCount":12683,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":55.24146372751445,"pubTatorScore":1.8241941306318155,"self":"https://pharos.nih.gov/idg/api/v1/targets(12462)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12462)/publications"},"_namespace":null},{"id":12463,"version":2,"created":1554952380000,"modified":1554952382000,"deprecated":false,"name":"A-kinase anchor protein 3","accession":"O75969","gene":"AKAP3","description":"May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.366350390509536,"antibodyCount":139,"monoclonalCount":5,"pubmedCount":null,"jensenScore":24.006425,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.674460894186037,"pubTatorScore":1.3760882103404002,"self":"https://pharos.nih.gov/idg/api/v1/targets(12463)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12463)/publications"},"_namespace":null},{"id":12464,"version":2,"created":1554952383000,"modified":1554952386000,"deprecated":false,"name":"ATP synthase subunit g, mitochondrial","accession":"O75964","gene":"ATP5MG","description":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.27243939533925987,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.148838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4895555325608014,"self":"https://pharos.nih.gov/idg/api/v1/targets(12464)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/properties"},"_links":{"count":1136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12464)/publications"},"_namespace":null},{"id":12465,"version":3,"created":1554952387000,"modified":1555040737000,"deprecated":false,"name":"Thyroid transcription factor 1-associated protein 26","accession":"Q9P031","gene":"CCDC59","description":"Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5583084769504687,"antibodyCount":42,"monoclonalCount":1,"pubmedCount":null,"jensenScore":3.714118,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":35.59912999543629,"pubTatorScore":0.9208187365805955,"self":"https://pharos.nih.gov/idg/api/v1/targets(12465)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12465)/publications"},"_namespace":null},{"id":12466,"version":2,"created":1554952391000,"modified":1554952396000,"deprecated":false,"name":"Triple functional domain protein","accession":"O75962","gene":"TRIO","description":"Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.0408440835763035,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":103.770594,"patentCount":37881,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.19637339022723,"pubTatorScore":2.274341085184572,"self":"https://pharos.nih.gov/idg/api/v1/targets(12466)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(12466)/publications"},"_namespace":null},{"id":12467,"version":3,"created":1554952396000,"modified":1555040738000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4","accession":"Q9P032","gene":"NDUFAF4","description":"Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.6752998144118738,"antibodyCount":94,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.322403,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":32.09590345626288,"pubTatorScore":0.9364092780719181,"self":"https://pharos.nih.gov/idg/api/v1/targets(12467)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(12467)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(12467)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12467)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12467)/publications"},"_namespace":null},{"id":12468,"version":2,"created":1554952405000,"modified":1554952408000,"deprecated":false,"name":"N-lysine methyltransferase SETD6","accession":"Q8TBK2","gene":"SETD6","description":"Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.7937515798673549,"antibodyCount":83,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.875226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.653192629871356,"pubTatorScore":0.5867122869891247,"self":"https://pharos.nih.gov/idg/api/v1/targets(12468)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12468)/publications"},"_namespace":null},{"id":12469,"version":3,"created":1554952409000,"modified":1555040742000,"deprecated":false,"name":"Syndecan-2","accession":"P34741","gene":"SDC2","description":"Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.097649485687846,"antibodyCount":184,"monoclonalCount":70,"pubmedCount":null,"jensenScore":138.076166,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":49,"knowledgeAvailability":41.91573046785135,"pubTatorScore":2.4737535567176505,"self":"https://pharos.nih.gov/idg/api/v1/targets(12469)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(12469)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(12469)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12469)/synonyms"},"_publications":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(12469)/publications"},"_namespace":null},{"id":12470,"version":2,"created":1554952414000,"modified":1554952420000,"deprecated":false,"name":"Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3","accession":"Q9P035","gene":"HACD3","description":"Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9162140345557221,"antibodyCount":90,"monoclonalCount":10,"pubmedCount":null,"jensenScore":75.935745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.8016095360664,"pubTatorScore":1.138175360150364,"self":"https://pharos.nih.gov/idg/api/v1/targets(12470)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(12470)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(12470)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12470)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12470)/publications"},"_namespace":null},{"id":12471,"version":2,"created":1554952420000,"modified":1554952424000,"deprecated":false,"name":"Histidine decarboxylase","accession":"P19113","gene":"HDC","description":"Catalyzes the biosynthesis of histamine from histidine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.653930779036947,"antibodyCount":175,"monoclonalCount":0,"pubmedCount":null,"jensenScore":472.210767,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.409211936134334,"pubTatorScore":2.6711732760833478,"self":"https://pharos.nih.gov/idg/api/v1/targets(12471)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(12471)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(12471)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12471)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12471)/publications"},"_namespace":null},{"id":12472,"version":2,"created":1554952425000,"modified":1554952427000,"deprecated":false,"name":"Fez family zinc finger protein 2","accession":"Q8TBJ5","gene":"FEZF2","description":"Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.080333654040553,"antibodyCount":100,"monoclonalCount":2,"pubmedCount":null,"jensenScore":117.904197,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.80665925635441,"pubTatorScore":2.96171745278256,"self":"https://pharos.nih.gov/idg/api/v1/targets(12472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(12472)/properties"},"_links":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12472)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12472)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12472)/publications"},"_namespace":null},{"id":12473,"version":2,"created":1554952428000,"modified":1554952428000,"deprecated":false,"name":"PRAME family member 27","accession":"A3QJZ7","gene":"PRAMEF27","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12473)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12473)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12473)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12473)/publications"},"_namespace":null},{"id":12474,"version":2,"created":1554952428000,"modified":1554952428000,"deprecated":false,"name":"PRAME family member 22","accession":"A3QJZ6","gene":"PRAMEF22","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.3826976454742246,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12474)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12474)/properties"},"_links":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12474)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12474)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12474)/publications"},"_namespace":null},{"id":12475,"version":2,"created":1554952428000,"modified":1554952432000,"deprecated":false,"name":"Solute carrier organic anion transporter family member 1A2","accession":"P46721","gene":"SLCO1A2","description":"Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.549895680640774,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":331.565057,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.309836202538374,"pubTatorScore":2.3298764643919245,"self":"https://pharos.nih.gov/idg/api/v1/targets(12475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(12475)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(12475)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(12475)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12475)/publications"},"_namespace":null},{"id":12476,"version":2,"created":1554952432000,"modified":1554952436000,"deprecated":false,"name":"Flotillin-1","accession":"O75955","gene":"FLOT1","description":"May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.134554293654382,"antibodyCount":277,"monoclonalCount":28,"pubmedCount":null,"jensenScore":128.766715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.73950981361359,"pubTatorScore":2.0251646679278545,"self":"https://pharos.nih.gov/idg/api/v1/targets(12476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":511,"href":"https://pharos.nih.gov/idg/api/v1/targets(12476)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12476)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12476)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12476)/publications"},"_namespace":null},{"id":12477,"version":2,"created":1554952437000,"modified":1554952440000,"deprecated":false,"name":"Cyclin-dependent kinase 2-associated protein 2","accession":"O75956","gene":"CDK2AP2","description":"Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8299160882925757,"antibodyCount":129,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.793155,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.6316307228284,"pubTatorScore":0.5481846924874552,"self":"https://pharos.nih.gov/idg/api/v1/targets(12477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12477)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(12477)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12477)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12477)/publications"},"_namespace":null},{"id":12478,"version":2,"created":1554952440000,"modified":1554952444000,"deprecated":false,"name":"DnaJ homolog subfamily B member 5","accession":"O75953","gene":"DNAJB5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2775728360430012,"antibodyCount":131,"monoclonalCount":22,"pubmedCount":null,"jensenScore":1.784867,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.264404299151987,"pubTatorScore":0.1910685328000928,"self":"https://pharos.nih.gov/idg/api/v1/targets(12478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(12478)/properties"},"_links":{"count":1009,"href":"https://pharos.nih.gov/idg/api/v1/targets(12478)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12478)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12478)/publications"},"_namespace":null},{"id":12479,"version":2,"created":1554952445000,"modified":1554952448000,"deprecated":false,"name":"Tetraspanin-9","accession":"O75954","gene":"TSPAN9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4687691742747739,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.165858,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.480184313427664,"pubTatorScore":0.9458093381177607,"self":"https://pharos.nih.gov/idg/api/v1/targets(12479)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(12479)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(12479)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12479)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12479)/publications"},"_namespace":null},{"id":12480,"version":2,"created":1554952449000,"modified":1554952449000,"deprecated":false,"name":"Lysozyme-like protein 6","accession":"O75951","gene":"LYZL6","description":"May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716). Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621). Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716). Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (PubMed:28182716).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9210255273417328,"antibodyCount":121,"monoclonalCount":1,"pubmedCount":null,"jensenScore":9.086057,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.44453193821811,"pubTatorScore":0.6145457380415658,"self":"https://pharos.nih.gov/idg/api/v1/targets(12480)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12480)/properties"},"_links":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12480)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12480)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12480)/publications"},"_namespace":null},{"id":12481,"version":2,"created":1554952449000,"modified":1554952453000,"deprecated":false,"name":"Calcium-binding tyrosine phosphorylation-regulated protein","accession":"O75952","gene":"CABYR","description":"May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.285788052323067,"antibodyCount":68,"monoclonalCount":3,"pubmedCount":null,"jensenScore":20.889745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.877200820298235,"pubTatorScore":1.3184111740819415,"self":"https://pharos.nih.gov/idg/api/v1/targets(12481)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(12481)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(12481)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(12481)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12481)/publications"},"_namespace":null},{"id":12482,"version":2,"created":1554952454000,"modified":1554952458000,"deprecated":false,"name":"Protein RUFY3","accession":"Q7L099","gene":"RUFY3","description":"Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3404517090666851,"antibodyCount":43,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.689685,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.87927983493805,"pubTatorScore":0.5812706778009593,"self":"https://pharos.nih.gov/idg/api/v1/targets(12482)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(12482)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12482)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12482)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12482)/publications"},"_namespace":null},{"id":12483,"version":3,"created":1554952459000,"modified":1555040744000,"deprecated":false,"name":"Phospholipid phosphatase-related protein type 1","accession":"Q8TBJ4","gene":"PLPPR1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.06214790530119616,"antibodyCount":28,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.128571,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":0.0,"pubTatorScore":0.43933269383026263,"self":"https://pharos.nih.gov/idg/api/v1/targets(12483)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(12483)/properties"},"_links":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(12483)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12483)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12483)/publications"},"_namespace":null},{"id":12484,"version":3,"created":1554952462000,"modified":1555040745000,"deprecated":false,"name":"Guanylate cyclase soluble subunit alpha-2","accession":"P33402","gene":"GUCY1A2","description":"Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.3933523349353771,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":23.939258,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.12514527025227,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12484)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(12484)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(12484)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12484)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12484)/publications"},"_namespace":null},{"id":12485,"version":3,"created":1554952482000,"modified":1555040747000,"deprecated":false,"name":"Trans-3-hydroxy-L-proline dehydratase","accession":"Q96EM0","gene":"L3HYPDH","description":"Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.3010299956639812,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":25.76875286676895,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(12485)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(12485)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(12485)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12485)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12485)/publications"},"_namespace":null},{"id":12486,"version":2,"created":1554952485000,"modified":1554952487000,"deprecated":false,"name":"F-box/WD repeat-containing protein 12","accession":"Q6X9E4","gene":"FBXW12","description":"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4036923398773662,"antibodyCount":129,"monoclonalCount":22,"pubmedCount":null,"jensenScore":2.944445,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.542083987562824,"pubTatorScore":0.425968786559088,"self":"https://pharos.nih.gov/idg/api/v1/targets(12486)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(12486)/properties"},"_links":{"count":653,"href":"https://pharos.nih.gov/idg/api/v1/targets(12486)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12486)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12486)/publications"},"_namespace":null},{"id":12487,"version":2,"created":1554952488000,"modified":1554952493000,"deprecated":false,"name":"Phosphatidylcholine translocator ABCB4","accession":"P21439","gene":"ABCB4","description":"Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.9134622162467925,"antibodyCount":146,"monoclonalCount":20,"pubmedCount":null,"jensenScore":806.623926,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.12551748968496,"pubTatorScore":2.695638041633195,"self":"https://pharos.nih.gov/idg/api/v1/targets(12487)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":477,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12487)/publications"},"_namespace":null},{"id":12488,"version":2,"created":1554952494000,"modified":1554952495000,"deprecated":false,"name":"Testis-specific Y-encoded protein 4","accession":"P0CV99","gene":"TSPY4","description":"Unknown. May be involved in sperm differentiation and proliferation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2521814275057435,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.918518,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.06694654146226692,"self":"https://pharos.nih.gov/idg/api/v1/targets(12488)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/properties"},"_links":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12488)/publications"},"_namespace":null},{"id":12489,"version":2,"created":1554952495000,"modified":1554952495000,"deprecated":false,"name":"Testis-specific Y-encoded protein 3","accession":"P0CV98","gene":"TSPY3","description":"Unknown. May be involved in sperm differentiation and proliferation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9555366790272941,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":88.146199,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.184290391894215,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12489)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/properties"},"_links":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12489)/publications"},"_namespace":null},{"id":12490,"version":2,"created":1554952495000,"modified":1554952496000,"deprecated":false,"name":"Paraneoplastic antigen-like protein 8C","accession":"A0A1B0GUJ8","gene":"PNMA8C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/properties"},"_links":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/links"},"_synonyms":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12490)/publications"},"_namespace":null},{"id":12491,"version":3,"created":1554952496000,"modified":1555040748000,"deprecated":false,"name":"Inhibin beta A chain","accession":"P08476","gene":"INHBA","description":"Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.921082668022149,"antibodyCount":319,"monoclonalCount":27,"pubmedCount":null,"jensenScore":76.579612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.626460478734785,"pubTatorScore":2.1975680899531724,"self":"https://pharos.nih.gov/idg/api/v1/targets(12491)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":569,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/synonyms"},"_publications":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12491)/publications"},"_namespace":null},{"id":12492,"version":2,"created":1554952502000,"modified":1554952505000,"deprecated":false,"name":"Arylacetamide deacetylase","accession":"P22760","gene":"AADAC","description":"Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3341824157762991,"antibodyCount":116,"monoclonalCount":22,"pubmedCount":null,"jensenScore":25.603439,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.4159309032468,"pubTatorScore":1.9562634460194184,"self":"https://pharos.nih.gov/idg/api/v1/targets(12492)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/properties"},"_links":{"count":730,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12492)/publications"},"_namespace":null},{"id":12493,"version":4,"created":1554952506000,"modified":1555040751000,"deprecated":false,"name":"Neprilysin","accession":"P08473","gene":"MME","description":"Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.641684359917804,"antibodyCount":1505,"monoclonalCount":1031,"pubmedCount":null,"jensenScore":4375.794389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":44.895560672234154,"pubTatorScore":3.389925144557807,"self":"https://pharos.nih.gov/idg/api/v1/targets(12493)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":668,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/properties"},"_links":{"count":1706,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/links"},"_synonyms":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/synonyms"},"_publications":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(12493)/publications"},"_namespace":null},{"id":12494,"version":3,"created":1554952576000,"modified":1555040755000,"deprecated":false,"name":"Fatty acid-binding protein, liver","accession":"P07148","gene":"FABP1","description":"Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.578401008322777,"antibodyCount":411,"monoclonalCount":152,"pubmedCount":null,"jensenScore":448.755749,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.320043003154296,"pubTatorScore":2.469549672128679,"self":"https://pharos.nih.gov/idg/api/v1/targets(12494)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(12494)/publications"},"_namespace":null},{"id":12495,"version":2,"created":1554952583000,"modified":1554952586000,"deprecated":false,"name":"Zinc finger protein 703","accession":"Q9H7S9","gene":"ZNF703","description":"Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2137661365302286,"antibodyCount":190,"monoclonalCount":21,"pubmedCount":null,"jensenScore":18.747659,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.786653356414913,"pubTatorScore":1.1785552468864084,"self":"https://pharos.nih.gov/idg/api/v1/targets(12495)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12495)/publications"},"_namespace":null},{"id":12496,"version":3,"created":1554952587000,"modified":1555040756000,"deprecated":false,"name":"Neogenin","accession":"Q92859","gene":"NEO1","description":"Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0746502575229893,"antibodyCount":123,"monoclonalCount":21,"pubmedCount":null,"jensenScore":120.240784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.797785699142445,"pubTatorScore":1.6149310517365645,"self":"https://pharos.nih.gov/idg/api/v1/targets(12496)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12496)/publications"},"_namespace":null},{"id":12497,"version":2,"created":1554952592000,"modified":1554952598000,"deprecated":false,"name":"Interferon regulatory factor 1","accession":"P10914","gene":"IRF1","description":"Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.903145580243671,"antibodyCount":366,"monoclonalCount":69,"pubmedCount":null,"jensenScore":827.710342,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.414395314946695,"pubTatorScore":2.6941043002526324,"self":"https://pharos.nih.gov/idg/api/v1/targets(12497)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":647,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/properties"},"_links":{"count":1241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/synonyms"},"_publications":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(12497)/publications"},"_namespace":null},{"id":12498,"version":2,"created":1554952599000,"modified":1554952603000,"deprecated":false,"name":"Caprin-2","accession":"Q6IMN6","gene":"CAPRIN2","description":"Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.869262782451758,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.575886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.81801779031291,"pubTatorScore":1.2619705132216792,"self":"https://pharos.nih.gov/idg/api/v1/targets(12498)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12498)/publications"},"_namespace":null},{"id":12499,"version":2,"created":1554952604000,"modified":1554952610000,"deprecated":false,"name":"Hyaluronan and proteoglycan link protein 1","accession":"P10915","gene":"HAPLN1","description":"Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.182078483169025,"antibodyCount":162,"monoclonalCount":12,"pubmedCount":null,"jensenScore":145.56967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.673791835143064,"pubTatorScore":1.8732899617530543,"self":"https://pharos.nih.gov/idg/api/v1/targets(12499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12499)/publications"},"_namespace":null},{"id":12500,"version":2,"created":1554952613000,"modified":1554952618000,"deprecated":false,"name":"Protein atonal homolog 1","accession":"Q92858","gene":"ATOH1","description":"Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3048345279247013,"antibodyCount":481,"monoclonalCount":183,"pubmedCount":null,"jensenScore":206.542829,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.05164202268514,"pubTatorScore":2.0620777596299544,"self":"https://pharos.nih.gov/idg/api/v1/targets(12500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/properties"},"_links":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12500)/publications"},"_namespace":null},{"id":12501,"version":3,"created":1554952619000,"modified":1555040758000,"deprecated":false,"name":"Myosin regulatory light chain 2, ventricular/cardiac muscle isoform","accession":"P10916","gene":"MYL2","description":"Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.230215898056053,"antibodyCount":222,"monoclonalCount":102,"pubmedCount":null,"jensenScore":155.772952,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":37.422102107308675,"pubTatorScore":2.1552151501098535,"self":"https://pharos.nih.gov/idg/api/v1/targets(12501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(12501)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(12501)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12501)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12501)/publications"},"_namespace":null},{"id":12502,"version":3,"created":1554952623000,"modified":1555040759000,"deprecated":false,"name":"Intestinal-type alkaline phosphatase","accession":"P09923","gene":"ALPI","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.304788090140424,"antibodyCount":426,"monoclonalCount":176,"pubmedCount":null,"jensenScore":194.547744,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":28.642721912493535,"pubTatorScore":2.740777727174472,"self":"https://pharos.nih.gov/idg/api/v1/targets(12502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12502)/properties"},"_links":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12502)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12502)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12502)/publications"},"_namespace":null},{"id":12503,"version":3,"created":1554952625000,"modified":1555040760000,"deprecated":false,"name":"Acyl-CoA dehydrogenase family member 9, mitochondrial","accession":"Q9H845","gene":"ACAD9","description":"Required for mitochondrial complex I assembly (PubMed:20816094, PubMed:24158852). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo (PubMed:20816094, PubMed:24158852). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.312671556114758,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":22.002522,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":37.591563611030246,"pubTatorScore":1.3482645282661276,"self":"https://pharos.nih.gov/idg/api/v1/targets(12503)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(12503)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12503)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12503)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12503)/publications"},"_namespace":null},{"id":12504,"version":2,"created":1554952630000,"modified":1554952634000,"deprecated":false,"name":"Proto-oncogene DBL","accession":"P10911","gene":"MCF2","description":"Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5453273680896857,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":324.819418,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.1583251512592,"pubTatorScore":2.0299779810322565,"self":"https://pharos.nih.gov/idg/api/v1/targets(12504)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(12504)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(12504)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(12504)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12504)/publications"},"_namespace":null},{"id":12505,"version":3,"created":1554952634000,"modified":1555040762000,"deprecated":false,"name":"Growth hormone receptor","accession":"P10912","gene":"GHR","description":"Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.1197010085742476,"antibodyCount":236,"monoclonalCount":45,"pubmedCount":null,"jensenScore":1322.594932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":55.66818351689702,"pubTatorScore":3.114790721600278,"self":"https://pharos.nih.gov/idg/api/v1/targets(12505)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(12505)/properties"},"_links":{"count":1166,"href":"https://pharos.nih.gov/idg/api/v1/targets(12505)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(12505)/synonyms"},"_publications":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(12505)/publications"},"_namespace":null},{"id":12506,"version":2,"created":1554954389000,"modified":1554954392000,"deprecated":false,"name":"NIPA-like protein 2","accession":"Q9H841","gene":"NIPAL2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3010299956639812,"antibodyCount":85,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.971014420525677,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12506)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(12506)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(12506)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12506)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12506)/publications"},"_namespace":null},{"id":12507,"version":3,"created":1554954393000,"modified":1555040765000,"deprecated":false,"name":"Gem-associated protein 7","accession":"Q9H840","gene":"GEMIN7","description":"The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0543817518579448,"antibodyCount":105,"monoclonalCount":25,"pubmedCount":null,"jensenScore":11.0493,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":31.183485008159384,"pubTatorScore":0.966830517231238,"self":"https://pharos.nih.gov/idg/api/v1/targets(12507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12507)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(12507)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12507)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12507)/publications"},"_namespace":null},{"id":12508,"version":2,"created":1554954396000,"modified":1554954400000,"deprecated":false,"name":"Transcription factor HIVEP3","accession":"Q5T1R4","gene":"HIVEP3","description":"Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.722114712590753,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":49.916639,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.28046374011124,"pubTatorScore":1.466944082060763,"self":"https://pharos.nih.gov/idg/api/v1/targets(12508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(12508)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(12508)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12508)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12508)/publications"},"_namespace":null},{"id":12509,"version":2,"created":1554954401000,"modified":1554954402000,"deprecated":false,"name":"Putative coiled-coil domain-containing protein 196","accession":"A0A1B0GTZ2","gene":"CCDC196","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12509)/properties"},"_links":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(12509)/links"},"_synonyms":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12509)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12509)/publications"},"_namespace":null},{"id":12510,"version":2,"created":1554954402000,"modified":1554954404000,"deprecated":false,"name":"Protocadherin-23","accession":"Q6V1P9","gene":"DCHS2","description":"Calcium-dependent cell-adhesion protein.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.44734263530286583,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.788938,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.3534367269568,"pubTatorScore":0.570617067156432,"self":"https://pharos.nih.gov/idg/api/v1/targets(12510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12510)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(12510)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12510)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12510)/publications"},"_namespace":null},{"id":12511,"version":3,"created":1554954405000,"modified":1555040766000,"deprecated":false,"name":"Zymogen granule protein 16 homolog B","accession":"Q96DA0","gene":"ZG16B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3340589658668756,"antibodyCount":100,"monoclonalCount":22,"pubmedCount":null,"jensenScore":223.656398,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":16.16259968866771,"pubTatorScore":1.349947844277871,"self":"https://pharos.nih.gov/idg/api/v1/targets(12511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(12511)/properties"},"_links":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(12511)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12511)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12511)/publications"},"_namespace":null},{"id":12512,"version":3,"created":1554954409000,"modified":1555040767000,"deprecated":false,"name":"Ras-related protein Rab-39B","accession":"Q96DA2","gene":"RAB39B","description":"Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2673861729806528,"antibodyCount":128,"monoclonalCount":14,"pubmedCount":null,"jensenScore":18.570118,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":25.899577237473096,"pubTatorScore":1.1119048748764118,"self":"https://pharos.nih.gov/idg/api/v1/targets(12512)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(12512)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(12512)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12512)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12512)/publications"},"_namespace":null},{"id":12513,"version":3,"created":1554954413000,"modified":1555040768000,"deprecated":false,"name":"Caspase-10","accession":"Q92851","gene":"CASP10","description":"Isoform C is proteolytically inactive.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.9765261272135048,"antibodyCount":457,"monoclonalCount":57,"pubmedCount":null,"jensenScore":89.097296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.78294052569491,"pubTatorScore":2.1634633522026716,"self":"https://pharos.nih.gov/idg/api/v1/targets(12513)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(12513)/properties"},"_links":{"count":1089,"href":"https://pharos.nih.gov/idg/api/v1/targets(12513)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(12513)/synonyms"},"_publications":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12513)/publications"},"_namespace":null},{"id":12514,"version":2,"created":1554954419000,"modified":1554954422000,"deprecated":false,"name":"Mitochondrial import inner membrane translocase subunit TIM14","accession":"Q96DA6","gene":"DNAJC19","description":"Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3147851965759412,"antibodyCount":95,"monoclonalCount":22,"pubmedCount":null,"jensenScore":22.505283,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.724112252304685,"pubTatorScore":1.1094806424515704,"self":"https://pharos.nih.gov/idg/api/v1/targets(12514)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(12514)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(12514)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12514)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12514)/publications"},"_namespace":null},{"id":12515,"version":2,"created":1554954423000,"modified":1554954427000,"deprecated":false,"name":"Semaphorin-4D","accession":"Q92854","gene":"SEMA4D","description":"Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1824980936313456,"antibodyCount":525,"monoclonalCount":364,"pubmedCount":null,"jensenScore":176.348015,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.45297953042749,"pubTatorScore":2.192157570868929,"self":"https://pharos.nih.gov/idg/api/v1/targets(12515)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":522,"href":"https://pharos.nih.gov/idg/api/v1/targets(12515)/properties"},"_links":{"count":1105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12515)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12515)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12515)/publications"},"_namespace":null},{"id":12516,"version":2,"created":1554954428000,"modified":1554954430000,"deprecated":false,"name":"Nuclear pore complex-interacting protein family member B9","accession":"F8W1W9","gene":"NPIPB9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.831101317875723,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12516)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(12516)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(12516)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12516)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12516)/publications"},"_namespace":null},{"id":12517,"version":2,"created":1554954431000,"modified":1554954439000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase isozyme L1","accession":"P09936","gene":"UCHL1","description":"Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.1631823605934004,"antibodyCount":1378,"monoclonalCount":563,"pubmedCount":null,"jensenScore":1414.171765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.873109383367705,"pubTatorScore":2.9975801378743268,"self":"https://pharos.nih.gov/idg/api/v1/targets(12517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(12517)/properties"},"_links":{"count":1299,"href":"https://pharos.nih.gov/idg/api/v1/targets(12517)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(12517)/synonyms"},"_publications":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(12517)/publications"},"_namespace":null},{"id":12518,"version":3,"created":1554954442000,"modified":1554954597000,"deprecated":false,"name":"Growth hormone secretagogue receptor type 1","accession":"Q92847","gene":"GHSR","description":"Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.707205825617575,"antibodyCount":181,"monoclonalCount":20,"pubmedCount":null,"jensenScore":350.168302,"patentCount":34605,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.844328583686334,"pubTatorScore":2.6572445042204573,"self":"https://pharos.nih.gov/idg/api/v1/targets(12518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(12518)/properties"},"_links":{"count":825,"href":"https://pharos.nih.gov/idg/api/v1/targets(12518)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12518)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12518)/publications"},"_namespace":null},{"id":12519,"version":3,"created":1554954598000,"modified":1555040770000,"deprecated":false,"name":"Complement factor H","accession":"P08603","gene":"CFH","description":"Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.158721889157807,"antibodyCount":593,"monoclonalCount":235,"pubmedCount":null,"jensenScore":1420.919579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.038369666025254,"pubTatorScore":3.2284977154833157,"self":"https://pharos.nih.gov/idg/api/v1/targets(12519)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(12519)/properties"},"_links":{"count":1609,"href":"https://pharos.nih.gov/idg/api/v1/targets(12519)/links"},"_synonyms":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(12519)/synonyms"},"_publications":{"count":730,"href":"https://pharos.nih.gov/idg/api/v1/targets(12519)/publications"},"_namespace":null},{"id":12520,"version":2,"created":1554954609000,"modified":1554954612000,"deprecated":false,"name":"Zinc finger protein 665","accession":"Q9H7R5","gene":"ZNF665","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.539381956502357,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12520)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(12520)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(12520)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12520)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12520)/publications"},"_namespace":null},{"id":12521,"version":2,"created":1554954612000,"modified":1554954615000,"deprecated":false,"name":"Zinc finger protein 442","accession":"Q9H7R0","gene":"ZNF442","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.530022053021224,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12521)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12521)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(12521)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12521)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12521)/publications"},"_namespace":null},{"id":12522,"version":2,"created":1554954615000,"modified":1554954619000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 Z","accession":"Q9H832","gene":"UBE2Z","description":"Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7177233304952353,"antibodyCount":135,"monoclonalCount":18,"pubmedCount":null,"jensenScore":5.277761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.1263543370302,"pubTatorScore":0.7047223617971146,"self":"https://pharos.nih.gov/idg/api/v1/targets(12522)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12522)/publications"},"_namespace":null},{"id":12523,"version":2,"created":1554954619000,"modified":1554954621000,"deprecated":false,"name":"Noncompact myelin-associated protein","accession":"Q5T1S8","gene":"NCMAP","description":"Plays a role in myelin formation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.8519204791369825,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":73.783874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.41125759400234,"pubTatorScore":1.4078156423841977,"self":"https://pharos.nih.gov/idg/api/v1/targets(12523)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/properties"},"_links":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12523)/publications"},"_namespace":null},{"id":12524,"version":2,"created":1554954622000,"modified":1554954622000,"deprecated":false,"name":"Olfactory receptor 4A8","accession":"P0C604","gene":"OR4A8","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.322283686764133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12524)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12524)/publications"},"_namespace":null},{"id":12525,"version":2,"created":1554954622000,"modified":1554954622000,"deprecated":false,"name":"Testis-specific XK-related protein, Y-linked 2","accession":"A2RUG3","gene":"XKRY","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.22027915590490169,"self":"https://pharos.nih.gov/idg/api/v1/targets(12525)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12525)/publications"},"_namespace":null},{"id":12526,"version":3,"created":1554954622000,"modified":1555040774000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX17","accession":"Q92841","gene":"DDX17","description":"As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1633322565657727,"antibodyCount":159,"monoclonalCount":16,"pubmedCount":null,"jensenScore":141.141988,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":48.57620200696543,"pubTatorScore":2.0146823316129985,"self":"https://pharos.nih.gov/idg/api/v1/targets(12526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12526)/publications"},"_namespace":null},{"id":12527,"version":3,"created":1554954628000,"modified":1555040776000,"deprecated":false,"name":"Kinesin-associated protein 3","accession":"Q92845","gene":"KIFAP3","description":"Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3600735622420874,"antibodyCount":87,"monoclonalCount":16,"pubmedCount":null,"jensenScore":24.127086,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":43.057893020228406,"pubTatorScore":1.3896415802766462,"self":"https://pharos.nih.gov/idg/api/v1/targets(12527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12527)/publications"},"_namespace":null},{"id":12528,"version":2,"created":1554954633000,"modified":1554954637000,"deprecated":false,"name":"TRAF family member-associated NF-kappa-B activator","accession":"Q92844","gene":"TANK","description":"Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8199157204208893,"antibodyCount":373,"monoclonalCount":2,"pubmedCount":null,"jensenScore":67.507065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.89863909118823,"pubTatorScore":3.197120528491764,"self":"https://pharos.nih.gov/idg/api/v1/targets(12528)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12528)/publications"},"_namespace":null},{"id":12529,"version":2,"created":1554954638000,"modified":1554954639000,"deprecated":false,"name":"Placenta-expressed transcript 1 protein","accession":"Q6UQ28","gene":"PLET1","description":"Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9586280035444114,"antibodyCount":52,"monoclonalCount":20,"pubmedCount":null,"jensenScore":9.74545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.33157074021415,"pubTatorScore":0.3881800924202411,"self":"https://pharos.nih.gov/idg/api/v1/targets(12529)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/properties"},"_links":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12529)/publications"},"_namespace":null},{"id":12530,"version":3,"created":1554954640000,"modified":1555040778000,"deprecated":false,"name":"Bcl-2-like protein 2","accession":"Q92843","gene":"BCL2L2","description":"Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.088805091495287,"antibodyCount":298,"monoclonalCount":33,"pubmedCount":null,"jensenScore":100.218886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.2015888873417,"pubTatorScore":2.032734683472833,"self":"https://pharos.nih.gov/idg/api/v1/targets(12530)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":481,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/properties"},"_links":{"count":1835,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/synonyms"},"_publications":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12530)/publications"},"_namespace":null},{"id":12531,"version":3,"created":1554954648000,"modified":1555040781000,"deprecated":false,"name":"Ectodysplasin-A","accession":"Q92838","gene":"EDA","description":"Isoform 3: Binds only to the receptor EDA2R.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1947234833103906,"antibodyCount":332,"monoclonalCount":72,"pubmedCount":null,"jensenScore":1441.098712,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":38.18174987056775,"pubTatorScore":3.0653471761045203,"self":"https://pharos.nih.gov/idg/api/v1/targets(12531)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12531)/publications"},"_namespace":null},{"id":12532,"version":3,"created":1554954655000,"modified":1555040784000,"deprecated":false,"name":"Proto-oncogene FRAT1","accession":"Q92837","gene":"FRAT1","description":"Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3272622603379274,"antibodyCount":87,"monoclonalCount":5,"pubmedCount":null,"jensenScore":23.029893,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.52364960873802,"pubTatorScore":1.377220677152157,"self":"https://pharos.nih.gov/idg/api/v1/targets(12532)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12532)/publications"},"_namespace":null},{"id":12533,"version":2,"created":1554954658000,"modified":1554954662000,"deprecated":false,"name":"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1","accession":"Q92835","gene":"INPP5D","description":"Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0694533740086722,"antibodyCount":374,"monoclonalCount":106,"pubmedCount":null,"jensenScore":104.731708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.042394029588145,"pubTatorScore":3.2036326469835386,"self":"https://pharos.nih.gov/idg/api/v1/targets(12533)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":484,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12533)/publications"},"_namespace":null},{"id":12534,"version":3,"created":1554954663000,"modified":1555040785000,"deprecated":false,"name":"Methyltransferase-like protein 8","accession":"Q9H825","gene":"METTL8","description":"Probable methyltransferase.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.426357,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.26147191674264,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12534)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12534)/publications"},"_namespace":null},{"id":12535,"version":2,"created":1554954666000,"modified":1554954669000,"deprecated":false,"name":"Hyaluronan synthase 1","accession":"Q92839","gene":"HAS1","description":"Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.158947272278501,"antibodyCount":126,"monoclonalCount":23,"pubmedCount":null,"jensenScore":1400.640487,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.014297000807037,"pubTatorScore":2.2062031019114747,"self":"https://pharos.nih.gov/idg/api/v1/targets(12535)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12535)/publications"},"_namespace":null},{"id":12536,"version":2,"created":1554954670000,"modified":1554954671000,"deprecated":false,"name":"Lipase member M","accession":"Q5VYY2","gene":"LIPM","description":"Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9904868541211794,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.638228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.268279069606658,"pubTatorScore":0.535715927820995,"self":"https://pharos.nih.gov/idg/api/v1/targets(12536)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/properties"},"_links":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12536)/publications"},"_namespace":null},{"id":12537,"version":2,"created":1554954672000,"modified":1554954674000,"deprecated":false,"name":"Trafficking protein particle complex subunit 3-like protein","accession":"Q5T215","gene":"TRAPPC3L","description":"May play a role in vesicular transport from endoplasmic reticulum to Golgi.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.117647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.928225681294858,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(12537)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/properties"},"_links":{"count":690,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12537)/publications"},"_namespace":null},{"id":12538,"version":2,"created":1554954675000,"modified":1554954675000,"deprecated":false,"name":"Proline-rich protein 31","accession":"Q5SQ13","gene":"PRR31","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.228461329915586,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12538)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/properties"},"_links":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12538)/publications"},"_namespace":null},{"id":12539,"version":2,"created":1554954675000,"modified":1554954679000,"deprecated":false,"name":"Histone acetyltransferase KAT2A","accession":"Q92830","gene":"KAT2A","description":"Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.46486544601553,"antibodyCount":262,"monoclonalCount":70,"pubmedCount":null,"jensenScore":271.896971,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.82502073150457,"pubTatorScore":2.167286732158134,"self":"https://pharos.nih.gov/idg/api/v1/targets(12539)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12539)/publications"},"_namespace":null},{"id":12540,"version":3,"created":1554954680000,"modified":1555040786000,"deprecated":false,"name":"TATA box-binding protein-associated factor RNA polymerase I subunit B","accession":"Q53T94","gene":"TAF1B","description":"Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8807700833647377,"antibodyCount":66,"monoclonalCount":21,"pubmedCount":null,"jensenScore":6.781295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.642579886643105,"pubTatorScore":1.1156248548030947,"self":"https://pharos.nih.gov/idg/api/v1/targets(12540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12540)/publications"},"_namespace":null},{"id":12541,"version":3,"created":1554954683000,"modified":1555040787000,"deprecated":false,"name":"X-linked retinitis pigmentosa GTPase regulator","accession":"Q92834","gene":"RPGR","description":"Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.403270986846508,"antibodyCount":128,"monoclonalCount":1,"pubmedCount":null,"jensenScore":259.08834,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":40.740495680079945,"pubTatorScore":2.448172774499201,"self":"https://pharos.nih.gov/idg/api/v1/targets(12541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/properties"},"_links":{"count":1170,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/synonyms"},"_publications":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(12541)/publications"},"_namespace":null},{"id":12542,"version":2,"created":1554954690000,"modified":1554954693000,"deprecated":false,"name":"Pleckstrin homology domain-containing family G member 2","accession":"Q9H7P9","gene":"PLEKHG2","description":"May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.502778753326142,"antibodyCount":36,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.97373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.26047228374131,"pubTatorScore":1.2609186760189277,"self":"https://pharos.nih.gov/idg/api/v1/targets(12542)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12542)/publications"},"_namespace":null},{"id":12543,"version":2,"created":1554954694000,"modified":1554954698000,"deprecated":false,"name":"Protein Jumonji","accession":"Q92833","gene":"JARID2","description":"Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-1.8013618794845636,"antibodyCount":135,"monoclonalCount":3,"pubmedCount":null,"jensenScore":65.274338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.07601660974156,"pubTatorScore":1.6006961107626145,"self":"https://pharos.nih.gov/idg/api/v1/targets(12543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12543)/publications"},"_namespace":null},{"id":12544,"version":2,"created":1554954699000,"modified":1554954702000,"deprecated":false,"name":"DnaJ homolog subfamily C member 18","accession":"Q9H819","gene":"DNAJC18","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.749510638042846,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12544)/publications"},"_namespace":null},{"id":12545,"version":3,"created":1554954703000,"modified":1555040789000,"deprecated":false,"name":"Protein kinase C-binding protein NELL1","accession":"Q92832","gene":"NELL1","description":"Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.766788827412028,"antibodyCount":85,"monoclonalCount":39,"pubmedCount":null,"jensenScore":76.347391,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":34.52192057707536,"pubTatorScore":1.6877780249975094,"self":"https://pharos.nih.gov/idg/api/v1/targets(12545)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(12545)/properties"},"_links":{"count":728,"href":"https://pharos.nih.gov/idg/api/v1/targets(12545)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(12545)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12545)/publications"},"_namespace":null},{"id":12546,"version":3,"created":1554954707000,"modified":1555040791000,"deprecated":false,"name":"Histone acetyltransferase KAT2B","accession":"Q92831","gene":"KAT2B","description":"Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.6284666757210173,"antibodyCount":331,"monoclonalCount":138,"pubmedCount":null,"jensenScore":372.001389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":51.18190002601317,"pubTatorScore":2.5911611121273848,"self":"https://pharos.nih.gov/idg/api/v1/targets(12546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":687,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/properties"},"_links":{"count":1232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/links"},"_synonyms":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/synonyms"},"_publications":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12546)/publications"},"_namespace":null},{"id":12547,"version":3,"created":1554954716000,"modified":1555040793000,"deprecated":false,"name":"Multivesicular body subunit 12B","accession":"Q9H7P6","gene":"MVB12B","description":"Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0666807933532423,"antibodyCount":19,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.654701,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.06373750108149,"pubTatorScore":0.6460300526505441,"self":"https://pharos.nih.gov/idg/api/v1/targets(12547)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12547)/publications"},"_namespace":null},{"id":12548,"version":3,"created":1554954719000,"modified":1555040794000,"deprecated":false,"name":"5' exonuclease Apollo","accession":"Q9H816","gene":"DCLRE1B","description":"5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1523148336799225,"antibodyCount":78,"monoclonalCount":8,"pubmedCount":null,"jensenScore":16.040707,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.00039829965596,"pubTatorScore":1.5049991433708312,"self":"https://pharos.nih.gov/idg/api/v1/targets(12548)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12548)/publications"},"_namespace":null},{"id":12549,"version":3,"created":1554954724000,"modified":1555040795000,"deprecated":false,"name":"Interferon-induced protein with tetratricopeptide repeats 2","accession":"P09913","gene":"IFIT2","description":"IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.744308120720655,"antibodyCount":144,"monoclonalCount":4,"pubmedCount":null,"jensenScore":52.493359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":31.436400956481833,"pubTatorScore":2.0866755085225486,"self":"https://pharos.nih.gov/idg/api/v1/targets(12549)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(12549)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(12549)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12549)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12549)/publications"},"_namespace":null},{"id":12550,"version":2,"created":1554954729000,"modified":1554954733000,"deprecated":false,"name":"Interferon-induced protein with tetratricopeptide repeats 1","accession":"P09914","gene":"IFIT1","description":"Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0173792101386363,"antibodyCount":160,"monoclonalCount":12,"pubmedCount":null,"jensenScore":92.943419,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.65252256854201,"pubTatorScore":2.674414680639298,"self":"https://pharos.nih.gov/idg/api/v1/targets(12550)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(12550)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(12550)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12550)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12550)/publications"},"_namespace":null},{"id":12551,"version":2,"created":1554954734000,"modified":1554954737000,"deprecated":false,"name":"Homeobox protein Hox-B13","accession":"Q92826","gene":"HOXB13","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.0457835490113507,"antibodyCount":217,"monoclonalCount":19,"pubmedCount":null,"jensenScore":122.192164,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.40378757670917,"pubTatorScore":2.104436293836453,"self":"https://pharos.nih.gov/idg/api/v1/targets(12551)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(12551)/properties"},"_links":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(12551)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12551)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12551)/publications"},"_namespace":null},{"id":12552,"version":2,"created":1554954737000,"modified":1554954741000,"deprecated":false,"name":"Interferon alpha-inducible protein 6","accession":"P09912","gene":"IFI6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2275749405548004,"antibodyCount":120,"monoclonalCount":8,"pubmedCount":null,"jensenScore":16.685342,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.67195613459903,"pubTatorScore":1.8450496445041877,"self":"https://pharos.nih.gov/idg/api/v1/targets(12552)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(12552)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(12552)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12552)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12552)/publications"},"_namespace":null},{"id":12553,"version":2,"created":1554954742000,"modified":1554954748000,"deprecated":false,"name":"Proprotein convertase subtilisin/kexin type 5","accession":"Q92824","gene":"PCSK5","description":"Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.8834154986931235,"antibodyCount":143,"monoclonalCount":2,"pubmedCount":null,"jensenScore":751.241418,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.34287578133101,"pubTatorScore":2.56725093719782,"self":"https://pharos.nih.gov/idg/api/v1/targets(12553)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(12553)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(12553)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12553)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12553)/publications"},"_namespace":null},{"id":12554,"version":4,"created":1554954750000,"modified":1555040797000,"deprecated":false,"name":"Arachidonate 5-lipoxygenase","accession":"P09917","gene":"ALOX5","description":"Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.127104016635444,"antibodyCount":492,"monoclonalCount":40,"pubmedCount":null,"jensenScore":1408.876507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":36,"knowledgeAvailability":49.88585894561084,"pubTatorScore":3.2624544451763082,"self":"https://pharos.nih.gov/idg/api/v1/targets(12554)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":644,"href":"https://pharos.nih.gov/idg/api/v1/targets(12554)/properties"},"_links":{"count":2091,"href":"https://pharos.nih.gov/idg/api/v1/targets(12554)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(12554)/synonyms"},"_publications":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12554)/publications"},"_namespace":null},{"id":12555,"version":3,"created":1554955012000,"modified":1555040801000,"deprecated":false,"name":"Phosphorylated adapter RNA export protein","accession":"Q9H814","gene":"PHAX","description":"A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1464233955377623,"antibodyCount":141,"monoclonalCount":3,"pubmedCount":null,"jensenScore":14.332863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.72026693024269,"pubTatorScore":0.9657502687728069,"self":"https://pharos.nih.gov/idg/api/v1/targets(12555)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(12555)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(12555)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12555)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12555)/publications"},"_namespace":null},{"id":12556,"version":3,"created":1554955016000,"modified":1555040802000,"deprecated":false,"name":"Coronin-2A","accession":"Q92828","gene":"CORO2A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.549051963065156,"antibodyCount":74,"monoclonalCount":2,"pubmedCount":null,"jensenScore":34.885591,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.38404772260506,"pubTatorScore":1.356540640538906,"self":"https://pharos.nih.gov/idg/api/v1/targets(12556)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12556)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(12556)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12556)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12556)/publications"},"_namespace":null},{"id":12557,"version":3,"created":1554955020000,"modified":1555040806000,"deprecated":false,"name":"Transmembrane protein 206","accession":"Q9H813","gene":"TMEM206","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":84,"knowledgeAvailability":27.534305978182037,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12557)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(12557)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(12557)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12557)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12557)/publications"},"_namespace":null},{"id":12558,"version":3,"created":1554955024000,"modified":1555040808000,"deprecated":false,"name":"Zinc finger protein 324B","accession":"Q6AW86","gene":"ZNF324B","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.38021124171160603,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":76,"knowledgeAvailability":24.783144930015215,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12558)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12558)/properties"},"_links":{"count":725,"href":"https://pharos.nih.gov/idg/api/v1/targets(12558)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12558)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12558)/publications"},"_namespace":null},{"id":12559,"version":2,"created":1554955027000,"modified":1554955028000,"deprecated":false,"name":"Uncharacterized protein C1orf141","accession":"Q5JVX7","gene":"C1orf141","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.20422158482160818,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.581319,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.5190851520278179,"self":"https://pharos.nih.gov/idg/api/v1/targets(12559)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12559)/properties"},"_links":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(12559)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12559)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12559)/publications"},"_namespace":null},{"id":12560,"version":2,"created":1554955028000,"modified":1554955034000,"deprecated":false,"name":"Granulocyte colony-stimulating factor","accession":"P09919","gene":"CSF3","description":"Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.832121694701945,"antibodyCount":816,"monoclonalCount":465,"pubmedCount":null,"jensenScore":6976.934375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.886548873893563,"pubTatorScore":3.9003968780659815,"self":"https://pharos.nih.gov/idg/api/v1/targets(12560)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(12560)/properties"},"_links":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(12560)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12560)/synonyms"},"_publications":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(12560)/publications"},"_namespace":null},{"id":12561,"version":3,"created":1554955035000,"modified":1555040809000,"deprecated":false,"name":"Solute carrier family 35 member F1","accession":"Q5T1Q4","gene":"SLC35F1","description":"Putative solute transporter.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":0.015821764908655625,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.842002,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.51997634480334,"pubTatorScore":-0.1623901000674845,"self":"https://pharos.nih.gov/idg/api/v1/targets(12561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12561)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(12561)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12561)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12561)/publications"},"_namespace":null},{"id":12562,"version":2,"created":1554955039000,"modified":1554955040000,"deprecated":false,"name":"Undifferentiated embryonic cell transcription factor 1","accession":"Q5T230","gene":"UTF1","description":"Acts as a transcriptional coactivator of ATF2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5273691779283964,"antibodyCount":205,"monoclonalCount":38,"pubmedCount":null,"jensenScore":38.489249,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.77364572529761,"pubTatorScore":1.4227781574246559,"self":"https://pharos.nih.gov/idg/api/v1/targets(12562)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12562)/properties"},"_links":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12562)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12562)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12562)/publications"},"_namespace":null},{"id":12563,"version":3,"created":1554955041000,"modified":1555040810000,"deprecated":false,"name":"Thioredoxin domain-containing protein 8","accession":"Q6A555","gene":"TXNDC8","description":"May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.648360013152404,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.231618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":16.011218843075863,"pubTatorScore":0.840494400990479,"self":"https://pharos.nih.gov/idg/api/v1/targets(12563)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12563)/properties"},"_links":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12563)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12563)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12563)/publications"},"_namespace":null},{"id":12564,"version":2,"created":1554955041000,"modified":1554955042000,"deprecated":false,"name":"Calcium homeostasis modulator protein 4","accession":"Q5JW98","gene":"CALHM4","description":"Pore-forming subunit of a voltage-gated ion channel.","idgFamily":"Ion Channel","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":113,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(12564)/properties"},"_links":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(12564)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12564)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12564)/publications"},"_namespace":null},{"id":12565,"version":3,"created":1554955043000,"modified":1555040810000,"deprecated":false,"name":"Neuronal cell adhesion molecule","accession":"Q92823","gene":"NRCAM","description":"Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.343808813317965,"antibodyCount":192,"monoclonalCount":126,"pubmedCount":null,"jensenScore":207.1864,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.60357998848079,"pubTatorScore":1.9548781407100677,"self":"https://pharos.nih.gov/idg/api/v1/targets(12565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(12565)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(12565)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12565)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12565)/publications"},"_namespace":null},{"id":12566,"version":2,"created":1554955048000,"modified":1554955050000,"deprecated":false,"name":"Transducin-like enhancer protein 6","accession":"Q9H808","gene":"TLE6","description":"As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8549563543774241,"antibodyCount":62,"monoclonalCount":6,"pubmedCount":null,"jensenScore":7.123161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.142392867865652,"pubTatorScore":0.2497802889533791,"self":"https://pharos.nih.gov/idg/api/v1/targets(12566)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(12566)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(12566)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12566)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12566)/publications"},"_namespace":null},{"id":12567,"version":3,"created":1554955051000,"modified":1555040812000,"deprecated":false,"name":"Gamma-glutamyl hydrolase","accession":"Q92820","gene":"GGH","description":"Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.4204713404824845,"antibodyCount":224,"monoclonalCount":8,"pubmedCount":null,"jensenScore":259.669805,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":40.155218550877635,"pubTatorScore":2.0721403393560593,"self":"https://pharos.nih.gov/idg/api/v1/targets(12567)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":457,"href":"https://pharos.nih.gov/idg/api/v1/targets(12567)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12567)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12567)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12567)/publications"},"_namespace":null},{"id":12568,"version":3,"created":1554955057000,"modified":1555040814000,"deprecated":false,"name":"Clusterin","accession":"P10909","gene":"CLU","description":"Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.2865094569060576,"antibodyCount":826,"monoclonalCount":280,"pubmedCount":null,"jensenScore":2016.39368,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":46.15977444436428,"pubTatorScore":2.949034939007917,"self":"https://pharos.nih.gov/idg/api/v1/targets(12568)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(12568)/properties"},"_links":{"count":1638,"href":"https://pharos.nih.gov/idg/api/v1/targets(12568)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12568)/synonyms"},"_publications":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(12568)/publications"},"_namespace":null},{"id":12569,"version":3,"created":1554955067000,"modified":1555040817000,"deprecated":false,"name":"Low affinity immunoglobulin gamma Fc region receptor III-A","accession":"P08637","gene":"FCGR3A","description":"Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.251850751018014,"antibodyCount":1252,"monoclonalCount":1035,"pubmedCount":null,"jensenScore":1691.480497,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":26.66325775516099,"pubTatorScore":3.311617798586532,"self":"https://pharos.nih.gov/idg/api/v1/targets(12569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":659,"href":"https://pharos.nih.gov/idg/api/v1/targets(12569)/properties"},"_links":{"count":1219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12569)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(12569)/synonyms"},"_publications":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(12569)/publications"},"_namespace":null},{"id":12570,"version":2,"created":1554955074000,"modified":1554955078000,"deprecated":false,"name":"Histone H1.0","accession":"P07305","gene":"H1F0","description":"Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.3353392242238806,"antibodyCount":328,"monoclonalCount":115,"pubmedCount":null,"jensenScore":2040.041729,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.5339151403306,"pubTatorScore":2.565494068060789,"self":"https://pharos.nih.gov/idg/api/v1/targets(12570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(12570)/properties"},"_links":{"count":1168,"href":"https://pharos.nih.gov/idg/api/v1/targets(12570)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12570)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12570)/publications"},"_namespace":null},{"id":12571,"version":3,"created":1554955079000,"modified":1555040819000,"deprecated":false,"name":"Tyrosine-protein kinase RYK","accession":"P34925","gene":"RYK","description":"May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.8708029958919832,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":79.302043,"patentCount":11176,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.21778098679269,"pubTatorScore":1.527064060380994,"self":"https://pharos.nih.gov/idg/api/v1/targets(12571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(12571)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(12571)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12571)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12571)/publications"},"_namespace":null},{"id":12572,"version":2,"created":1554955083000,"modified":1554955089000,"deprecated":false,"name":"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2","accession":"O00469","gene":"PLOD2","description":"Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.3457830157296606,"antibodyCount":127,"monoclonalCount":34,"pubmedCount":null,"jensenScore":220.429997,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.23501567453083,"pubTatorScore":2.231889289673586,"self":"https://pharos.nih.gov/idg/api/v1/targets(12572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(12572)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12572)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12572)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12572)/publications"},"_namespace":null},{"id":12573,"version":3,"created":1554955090000,"modified":1555040821000,"deprecated":false,"name":"Asialoglycoprotein receptor 2","accession":"P07307","gene":"ASGR2","description":"Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2973957115879465,"antibodyCount":172,"monoclonalCount":55,"pubmedCount":null,"jensenScore":1.242663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":26.741391240887168,"pubTatorScore":1.0177286974733089,"self":"https://pharos.nih.gov/idg/api/v1/targets(12573)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(12573)/properties"},"_links":{"count":746,"href":"https://pharos.nih.gov/idg/api/v1/targets(12573)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(12573)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12573)/publications"},"_namespace":null},{"id":12574,"version":3,"created":1554955093000,"modified":1555040822000,"deprecated":false,"name":"Asialoglycoprotein receptor 1","accession":"P07306","gene":"ASGR1","description":"Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5550578608094567,"antibodyCount":244,"monoclonalCount":26,"pubmedCount":null,"jensenScore":362.126013,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.47958646558144,"pubTatorScore":2.349410356571938,"self":"https://pharos.nih.gov/idg/api/v1/targets(12574)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(12574)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(12574)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12574)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(12574)/publications"},"_namespace":null},{"id":12575,"version":2,"created":1554955097000,"modified":1554955101000,"deprecated":false,"name":"Beta-mannosidase","accession":"O00462","gene":"MANBA","description":"Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.0255053477834375,"antibodyCount":50,"monoclonalCount":3,"pubmedCount":null,"jensenScore":103.777274,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.604941461462474,"pubTatorScore":1.757847725813929,"self":"https://pharos.nih.gov/idg/api/v1/targets(12575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(12575)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(12575)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12575)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12575)/publications"},"_namespace":null},{"id":12576,"version":3,"created":1554955102000,"modified":1555040823000,"deprecated":false,"name":"Golgi integral membrane protein 4","accession":"O00461","gene":"GOLIM4","description":"Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.443597622987203,"antibodyCount":86,"monoclonalCount":38,"pubmedCount":null,"jensenScore":27.243242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.40501944724819,"pubTatorScore":1.4366420947535392,"self":"https://pharos.nih.gov/idg/api/v1/targets(12576)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(12576)/properties"},"_links":{"count":1107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12576)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12576)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12576)/publications"},"_namespace":null},{"id":12577,"version":2,"created":1554955108000,"modified":1554955111000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX59","accession":"Q5T1V6","gene":"DDX59","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5910646009463765,"antibodyCount":152,"monoclonalCount":103,"pubmedCount":null,"jensenScore":4.211538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.682266196965635,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12577)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12577)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(12577)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12577)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12577)/publications"},"_namespace":null},{"id":12578,"version":2,"created":1554955112000,"modified":1554955116000,"deprecated":false,"name":"TNF receptor-associated factor 5","accession":"O00463","gene":"TRAF5","description":"Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5744926792047254,"antibodyCount":177,"monoclonalCount":64,"pubmedCount":null,"jensenScore":33.92901,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.99576090089765,"pubTatorScore":1.4782547449736358,"self":"https://pharos.nih.gov/idg/api/v1/targets(12578)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(12578)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(12578)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12578)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12578)/publications"},"_namespace":null},{"id":12579,"version":3,"created":1554955117000,"modified":1555040825000,"deprecated":false,"name":"Agrin","accession":"O00468","gene":"AGRN","description":"Agrin C-terminal 22 kDa fragment: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7384350149497334,"antibodyCount":122,"monoclonalCount":39,"pubmedCount":null,"jensenScore":569.809924,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.0784312209663,"pubTatorScore":2.48243360479449,"self":"https://pharos.nih.gov/idg/api/v1/targets(12579)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(12579)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12579)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12579)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12579)/publications"},"_namespace":null},{"id":12580,"version":2,"created":1554955122000,"modified":1554955124000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 20A2","accession":"Q5SQ80","gene":"ANKRD20A2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.950997701840725,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12580)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(12580)/properties"},"_links":{"count":585,"href":"https://pharos.nih.gov/idg/api/v1/targets(12580)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12580)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12580)/publications"},"_namespace":null},{"id":12581,"version":2,"created":1554955124000,"modified":1554955127000,"deprecated":false,"name":"Putative methyltransferase C9orf114","accession":"Q5T280","gene":"SPOUT1","description":"Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.42596873227228116,"antibodyCount":34,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12581)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(12581)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(12581)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12581)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12581)/publications"},"_namespace":null},{"id":12582,"version":2,"created":1554955127000,"modified":1554955130000,"deprecated":false,"name":"Meiosis-specific coiled-coil domain-containing protein MEIOC","accession":"A2RUB1","gene":"MEIOC","description":"Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2218487496163564,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.060606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12582)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(12582)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(12582)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12582)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12582)/publications"},"_namespace":null},{"id":12583,"version":2,"created":1554955130000,"modified":1554955134000,"deprecated":false,"name":"Protocadherin-19","accession":"Q8TAB3","gene":"PCDH19","description":"Potential calcium-dependent cell-adhesion protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6563753959581136,"antibodyCount":21,"monoclonalCount":7,"pubmedCount":null,"jensenScore":50.067215,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.18862231150414,"pubTatorScore":1.7753290447002528,"self":"https://pharos.nih.gov/idg/api/v1/targets(12583)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(12583)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(12583)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12583)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12583)/publications"},"_namespace":null},{"id":12584,"version":3,"created":1554955135000,"modified":1555040827000,"deprecated":false,"name":"Anaphase-promoting complex subunit 16","accession":"Q96DE5","gene":"ANAPC16","description":"Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.031408444708373,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.95238,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":30.306398452644043,"pubTatorScore":0.6638055768078405,"self":"https://pharos.nih.gov/idg/api/v1/targets(12584)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12584)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(12584)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12584)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12584)/publications"},"_namespace":null},{"id":12585,"version":2,"created":1554955139000,"modified":1554955142000,"deprecated":false,"name":"UPF0500 protein C1orf216","accession":"Q8TAB5","gene":"C1orf216","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12585)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(12585)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(12585)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12585)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12585)/publications"},"_namespace":null},{"id":12586,"version":3,"created":1554955142000,"modified":1555040828000,"deprecated":false,"name":"U8 snoRNA-decapping enzyme","accession":"Q96DE0","gene":"NUDT16","description":"RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0052650344342093,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":97.19285,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":31.28213918745677,"pubTatorScore":1.3583428159418276,"self":"https://pharos.nih.gov/idg/api/v1/targets(12586)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(12586)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(12586)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12586)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12586)/publications"},"_namespace":null},{"id":12587,"version":2,"created":1554955146000,"modified":1554955150000,"deprecated":false,"name":"Exocyst complex component 5","accession":"O00471","gene":"EXOC5","description":"Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4522003203218206,"antibodyCount":83,"monoclonalCount":3,"pubmedCount":null,"jensenScore":28.658888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.59929286723612,"pubTatorScore":1.2759143401233526,"self":"https://pharos.nih.gov/idg/api/v1/targets(12587)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(12587)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(12587)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12587)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12587)/publications"},"_namespace":null},{"id":12588,"version":3,"created":1554955151000,"modified":1555040829000,"deprecated":false,"name":"Ubiquitin recognition factor in ER-associated degradation protein 1","accession":"Q92890","gene":"UFD1","description":"Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.781584769521621,"antibodyCount":187,"monoclonalCount":59,"pubmedCount":null,"jensenScore":54.465064,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":1.7023473662591089,"self":"https://pharos.nih.gov/idg/api/v1/targets(12588)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(12588)/properties"},"_links":{"count":1170,"href":"https://pharos.nih.gov/idg/api/v1/targets(12588)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12588)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12588)/publications"},"_namespace":null},{"id":12589,"version":3,"created":1554955156000,"modified":1555040831000,"deprecated":false,"name":"Homeobox protein Meis1","accession":"O00470","gene":"MEIS1","description":"Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1784642006543793,"antibodyCount":204,"monoclonalCount":17,"pubmedCount":null,"jensenScore":146.213066,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":46.79469116296799,"pubTatorScore":1.982654093868161,"self":"https://pharos.nih.gov/idg/api/v1/targets(12589)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(12589)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(12589)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12589)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12589)/publications"},"_namespace":null},{"id":12590,"version":3,"created":1554955162000,"modified":1555040832000,"deprecated":false,"name":"Golgi apparatus protein 1","accession":"Q92896","gene":"GLG1","description":"Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8862397581176746,"antibodyCount":160,"monoclonalCount":33,"pubmedCount":null,"jensenScore":79.76936,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.57293638231359,"pubTatorScore":1.6830577603146557,"self":"https://pharos.nih.gov/idg/api/v1/targets(12590)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(12590)/properties"},"_links":{"count":1225,"href":"https://pharos.nih.gov/idg/api/v1/targets(12590)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12590)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(12590)/publications"},"_namespace":null},{"id":12591,"version":3,"created":1554955168000,"modified":1555040833000,"deprecated":false,"name":"Fructose-bisphosphate aldolase C","accession":"P09972","gene":"ALDOC","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6731488226497926,"antibodyCount":268,"monoclonalCount":75,"pubmedCount":null,"jensenScore":43.982396,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.20432089771153,"pubTatorScore":1.0064606509739242,"self":"https://pharos.nih.gov/idg/api/v1/targets(12591)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(12591)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(12591)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12591)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12591)/publications"},"_namespace":null},{"id":12592,"version":2,"created":1554955173000,"modified":1554955174000,"deprecated":false,"name":"Proline-rich protein 30","accession":"Q53SZ7","gene":"PRR30","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.3222192947339193,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.033333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.143291025878524,"pubTatorScore":-1.1760890875887005,"self":"https://pharos.nih.gov/idg/api/v1/targets(12592)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12592)/properties"},"_links":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(12592)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12592)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12592)/publications"},"_namespace":null},{"id":12593,"version":2,"created":1554955174000,"modified":1554955177000,"deprecated":false,"name":"Coiled-coil domain-containing protein 66","accession":"A2RUB6","gene":"CCDC66","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5965970904149265,"antibodyCount":79,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.06993,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.091368513106023,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12593)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12593)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(12593)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12593)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12593)/publications"},"_namespace":null},{"id":12594,"version":2,"created":1554955178000,"modified":1554955181000,"deprecated":false,"name":"Acylphosphatase-1","accession":"P07311","gene":"ACYP1","description":"Its physiological role is not yet clear.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7203347438640505,"antibodyCount":145,"monoclonalCount":14,"pubmedCount":null,"jensenScore":5.147835,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.224588510158526,"pubTatorScore":0.5494297407497827,"self":"https://pharos.nih.gov/idg/api/v1/targets(12594)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(12594)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(12594)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12594)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12594)/publications"},"_namespace":null},{"id":12595,"version":2,"created":1554955182000,"modified":1554955182000,"deprecated":false,"name":"Putative coiled-coil domain-containing protein 26","accession":"Q8TAB7","gene":"CCDC26","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.0121351801785,"pubTatorScore":0.691670706707128,"self":"https://pharos.nih.gov/idg/api/v1/targets(12595)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12595)/properties"},"_links":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12595)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12595)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12595)/publications"},"_namespace":null},{"id":12596,"version":2,"created":1554955183000,"modified":1554955184000,"deprecated":false,"name":"Protein CXorf40B","accession":"Q96DE9","gene":"CXorf40B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(12596)/properties"},"_links":{"count":744,"href":"https://pharos.nih.gov/idg/api/v1/targets(12596)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12596)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12596)/publications"},"_namespace":null},{"id":12597,"version":2,"created":1554955185000,"modified":1554955185000,"deprecated":false,"name":"Gamma-crystallin B","accession":"P07316","gene":"CRYGB","description":"Crystallins are the dominant structural components of the vertebrate eye lens.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2210287077412554,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":153.957749,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.513934223951466,"pubTatorScore":0.8909143921008109,"self":"https://pharos.nih.gov/idg/api/v1/targets(12597)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12597)/properties"},"_links":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(12597)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12597)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12597)/publications"},"_namespace":null},{"id":12598,"version":2,"created":1554955186000,"modified":1554955191000,"deprecated":false,"name":"Integrin alpha-5","accession":"P08648","gene":"ITGA5","description":"(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for human metapneumovirus (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:24478423). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2912995755840067,"antibodyCount":826,"monoclonalCount":471,"pubmedCount":null,"jensenScore":169.054476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.29812390254094,"pubTatorScore":2.4153844986485384,"self":"https://pharos.nih.gov/idg/api/v1/targets(12598)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":716,"href":"https://pharos.nih.gov/idg/api/v1/targets(12598)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(12598)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12598)/synonyms"},"_publications":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12598)/publications"},"_namespace":null},{"id":12599,"version":3,"created":1554955193000,"modified":1554955683000,"deprecated":false,"name":"Bifunctional epoxide hydrolase 2","accession":"P34913","gene":"EPHX2","description":"Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.572663225590778,"antibodyCount":245,"monoclonalCount":52,"pubmedCount":null,"jensenScore":349.08708,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.91487686439599,"pubTatorScore":2.5919234420891106,"self":"https://pharos.nih.gov/idg/api/v1/targets(12599)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":565,"href":"https://pharos.nih.gov/idg/api/v1/targets(12599)/properties"},"_links":{"count":2571,"href":"https://pharos.nih.gov/idg/api/v1/targets(12599)/links"},"_synonyms":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(12599)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12599)/publications"},"_namespace":null},{"id":12600,"version":3,"created":1554955687000,"modified":1555040835000,"deprecated":false,"name":"Gamma-crystallin C","accession":"P07315","gene":"CRYGC","description":"Crystallins are the dominant structural components of the vertebrate eye lens.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2840801825664205,"antibodyCount":121,"monoclonalCount":57,"pubmedCount":null,"jensenScore":181.810517,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.261181901800327,"pubTatorScore":1.7637681599863237,"self":"https://pharos.nih.gov/idg/api/v1/targets(12600)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(12600)/properties"},"_links":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12600)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12600)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12600)/publications"},"_namespace":null},{"id":12601,"version":3,"created":1554955688000,"modified":1555040835000,"deprecated":false,"name":"T-cell surface glycoprotein CD8 beta chain","accession":"P10966","gene":"CD8B","description":"Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.021790713718595,"antibodyCount":672,"monoclonalCount":369,"pubmedCount":null,"jensenScore":179.678866,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":33.47379839129989,"pubTatorScore":2.058071272848507,"self":"https://pharos.nih.gov/idg/api/v1/targets(12601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(12601)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(12601)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(12601)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12601)/publications"},"_namespace":null},{"id":12602,"version":3,"created":1554955692000,"modified":1555040836000,"deprecated":false,"name":"RNA polymerase II elongation factor ELL2","accession":"O00472","gene":"ELL2","description":"Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1756960572279447,"antibodyCount":133,"monoclonalCount":11,"pubmedCount":null,"jensenScore":15.49007,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":41.34744811250482,"pubTatorScore":0.9611144641223247,"self":"https://pharos.nih.gov/idg/api/v1/targets(12602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12602)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(12602)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12602)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12602)/publications"},"_namespace":null},{"id":12603,"version":2,"created":1554955697000,"modified":1554955700000,"deprecated":false,"name":"PRKR-interacting protein 1","accession":"Q9H875","gene":"PRKRIP1","description":"Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.49732463832626667,"antibodyCount":46,"monoclonalCount":27,"pubmedCount":null,"jensenScore":2.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.63020375892919,"pubTatorScore":0.6509085126642363,"self":"https://pharos.nih.gov/idg/api/v1/targets(12603)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12603)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(12603)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12603)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12603)/publications"},"_namespace":null},{"id":12604,"version":2,"created":1554955700000,"modified":1554955704000,"deprecated":false,"name":"Protein EVI2B","accession":"P34910","gene":"EVI2B","description":"Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7525979978737805,"antibodyCount":126,"monoclonalCount":32,"pubmedCount":null,"jensenScore":5.336615,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.453743105002918,"pubTatorScore":0.6636950845135211,"self":"https://pharos.nih.gov/idg/api/v1/targets(12604)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(12604)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(12604)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12604)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12604)/publications"},"_namespace":null},{"id":12605,"version":2,"created":1554955705000,"modified":1554955707000,"deprecated":false,"name":"Sodium-dependent phosphate transport protein 4","accession":"O00476","gene":"SLC17A3","description":"Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.1087702254469174,"antibodyCount":46,"monoclonalCount":2,"pubmedCount":null,"jensenScore":13.349316,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.333924523393886,"pubTatorScore":1.0945692618175749,"self":"https://pharos.nih.gov/idg/api/v1/targets(12605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(12605)/properties"},"_links":{"count":584,"href":"https://pharos.nih.gov/idg/api/v1/targets(12605)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12605)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12605)/publications"},"_namespace":null},{"id":12606,"version":2,"created":1554955708000,"modified":1554955711000,"deprecated":false,"name":"Synapse differentiation-inducing gene protein 1","accession":"Q9H7V2","gene":"SYNDIG1","description":"May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.690196085674342,"antibodyCount":6,"monoclonalCount":4,"pubmedCount":null,"jensenScore":6.094084,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.730236950225574,"pubTatorScore":0.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(12606)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(12606)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(12606)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12606)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12606)/publications"},"_namespace":null},{"id":12607,"version":3,"created":1554955712000,"modified":1555040838000,"deprecated":false,"name":"High mobility group nucleosome-binding domain-containing protein 4","accession":"O00479","gene":"HMGN4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.209588155892058,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":164.107309,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":25.952498542581786,"pubTatorScore":1.7481880270062005,"self":"https://pharos.nih.gov/idg/api/v1/targets(12607)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12607)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(12607)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12607)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12607)/publications"},"_namespace":null},{"id":12608,"version":3,"created":1554955716000,"modified":1555040839000,"deprecated":false,"name":"Butyrophilin subfamily 3 member A3","accession":"O00478","gene":"BTN3A3","description":"Plays a role in T-cell responses in the adaptive immune response.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5851798513699255,"antibodyCount":99,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.247914,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":28.08160665391566,"pubTatorScore":0.5686206747909482,"self":"https://pharos.nih.gov/idg/api/v1/targets(12608)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(12608)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(12608)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12608)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12608)/publications"},"_namespace":null},{"id":12609,"version":3,"created":1554955721000,"modified":1555040840000,"deprecated":false,"name":"Protein RMD5 homolog A","accession":"Q9H871","gene":"RMND5A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.635112017846677,"antibodyCount":125,"monoclonalCount":48,"pubmedCount":null,"jensenScore":42.010981,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":32.31663885608718,"pubTatorScore":0.8688122469773821,"self":"https://pharos.nih.gov/idg/api/v1/targets(12609)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(12609)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(12609)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12609)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12609)/publications"},"_namespace":null},{"id":12610,"version":2,"created":1554955725000,"modified":1554955726000,"deprecated":false,"name":"Probable ribonuclease 11","accession":"Q8TAA1","gene":"RNASE11","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":126,"monoclonalCount":19,"pubmedCount":null,"jensenScore":0.571428,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.960642578498613,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12610)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12610)/properties"},"_links":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(12610)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12610)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12610)/publications"},"_namespace":null},{"id":12611,"version":2,"created":1554955726000,"modified":1554955729000,"deprecated":false,"name":"Putative uncharacterized protein C10orf128","accession":"Q5T292","gene":"C10orf128","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.3010299956639813,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.03125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12611)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(12611)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(12611)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12611)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12611)/publications"},"_namespace":null},{"id":12612,"version":2,"created":1554955730000,"modified":1554955732000,"deprecated":false,"name":"Proteasome subunit alpha type-7-like","accession":"Q8TAA3","gene":"PSMA8","description":"Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":51,"monoclonalCount":20,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.928363439904704,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12612)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":339,"href":"https://pharos.nih.gov/idg/api/v1/targets(12612)/properties"},"_links":{"count":579,"href":"https://pharos.nih.gov/idg/api/v1/targets(12612)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12612)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12612)/publications"},"_namespace":null},{"id":12613,"version":2,"created":1554955733000,"modified":1554955733000,"deprecated":false,"name":"Olfactory receptor 52Z1","accession":"P0C646","gene":"OR52Z1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.101223940357104,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12613)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12613)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12613)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(12613)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12613)/publications"},"_namespace":null},{"id":12614,"version":2,"created":1554955733000,"modified":1554955733000,"deprecated":false,"name":"Olfactory receptor 4E1","accession":"P0C645","gene":"OR4E1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.322283686764133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12614)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12614)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12614)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12614)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12614)/publications"},"_namespace":null},{"id":12615,"version":2,"created":1554955733000,"modified":1554955736000,"deprecated":false,"name":"Doublesex- and mab-3-related transcription factor A1","accession":"Q5VZB9","gene":"DMRTA1","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.564635087131481,"antibodyCount":114,"monoclonalCount":0,"pubmedCount":null,"jensenScore":369.407786,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.720435647862494,"pubTatorScore":0.6443892484484297,"self":"https://pharos.nih.gov/idg/api/v1/targets(12615)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12615)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(12615)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12615)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12615)/publications"},"_namespace":null},{"id":12616,"version":3,"created":1554955736000,"modified":1555040841000,"deprecated":false,"name":"Nuclear receptor subfamily 5 group A member 2","accession":"O00482","gene":"NR5A2","description":"Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.","idgFamily":"Nuclear Receptor","idgTDL":"Tchem","novelty":-2.493329939991558,"antibodyCount":303,"monoclonalCount":33,"pubmedCount":null,"jensenScore":323.534599,"patentCount":18143,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.53027058610862,"pubTatorScore":2.361761065827093,"self":"https://pharos.nih.gov/idg/api/v1/targets(12616)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":542,"href":"https://pharos.nih.gov/idg/api/v1/targets(12616)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(12616)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(12616)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(12616)/publications"},"_namespace":null},{"id":12617,"version":3,"created":1554955746000,"modified":1555040843000,"deprecated":false,"name":"tRNA wybutosine-synthesizing protein 5","accession":"A2RUC4","gene":"TYW5","description":"tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4313637645932818,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.571429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.59845552017981,"pubTatorScore":0.5642714699198773,"self":"https://pharos.nih.gov/idg/api/v1/targets(12617)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(12617)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(12617)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12617)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12617)/publications"},"_namespace":null},{"id":12618,"version":3,"created":1554955749000,"modified":1555040846000,"deprecated":false,"name":"Butyrophilin subfamily 3 member A1","accession":"O00481","gene":"BTN3A1","description":"Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3163954045818407,"antibodyCount":160,"monoclonalCount":52,"pubmedCount":null,"jensenScore":21.484709,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":29.435796400743403,"pubTatorScore":1.2676186104448774,"self":"https://pharos.nih.gov/idg/api/v1/targets(12618)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(12618)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(12618)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12618)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12618)/publications"},"_namespace":null},{"id":12619,"version":3,"created":1554955753000,"modified":1555040848000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 39","accession":"Q96DD0","gene":"LRRC39","description":"Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":121,"monoclonalCount":10,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":20.57767974535233,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12619)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(12619)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(12619)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12619)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12619)/publications"},"_namespace":null},{"id":12620,"version":2,"created":1554955756000,"modified":1554955760000,"deprecated":false,"name":"Vang-like protein 1","accession":"Q8TAA9","gene":"VANGL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8417095947073796,"antibodyCount":125,"monoclonalCount":8,"pubmedCount":null,"jensenScore":76.5192,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.471536395577466,"pubTatorScore":1.5123035012964519,"self":"https://pharos.nih.gov/idg/api/v1/targets(12620)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(12620)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(12620)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12620)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12620)/publications"},"_namespace":null},{"id":12621,"version":2,"created":1554955761000,"modified":1554955765000,"deprecated":false,"name":"Nuclear factor 1 C-type","accession":"P08651","gene":"NFIC","description":"Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5654390793936255,"antibodyCount":221,"monoclonalCount":61,"pubmedCount":null,"jensenScore":358.21422,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.77945521419269,"pubTatorScore":2.329560974622155,"self":"https://pharos.nih.gov/idg/api/v1/targets(12621)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(12621)/properties"},"_links":{"count":1229,"href":"https://pharos.nih.gov/idg/api/v1/targets(12621)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12621)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(12621)/publications"},"_namespace":null},{"id":12622,"version":2,"created":1554955766000,"modified":1554955769000,"deprecated":false,"name":"Mucin-6","accession":"Q6W4X9","gene":"MUC6","description":"May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.276830941941798,"antibodyCount":140,"monoclonalCount":92,"pubmedCount":null,"jensenScore":174.744232,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.100183299352352,"pubTatorScore":2.307487523090639,"self":"https://pharos.nih.gov/idg/api/v1/targets(12622)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(12622)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(12622)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12622)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12622)/publications"},"_namespace":null},{"id":12623,"version":3,"created":1554955770000,"modified":1555040849000,"deprecated":false,"name":"Osteoclast-stimulating factor 1","accession":"Q92882","gene":"OSTF1","description":"Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8494038029280253,"antibodyCount":155,"monoclonalCount":57,"pubmedCount":null,"jensenScore":62.333051,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":36.23239802494846,"pubTatorScore":1.9050437921774204,"self":"https://pharos.nih.gov/idg/api/v1/targets(12623)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(12623)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(12623)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12623)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12623)/publications"},"_namespace":null},{"id":12624,"version":2,"created":1554955775000,"modified":1554955777000,"deprecated":false,"name":"Gamma-crystallin D","accession":"P07320","gene":"CRYGD","description":"Crystallins are the dominant structural components of the vertebrate eye lens.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8696115460133242,"antibodyCount":164,"monoclonalCount":42,"pubmedCount":null,"jensenScore":731.370933,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.101097695893603,"pubTatorScore":2.4302391868794477,"self":"https://pharos.nih.gov/idg/api/v1/targets(12624)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12624)/properties"},"_links":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(12624)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12624)/synonyms"},"_publications":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12624)/publications"},"_namespace":null},{"id":12625,"version":3,"created":1554955778000,"modified":1555040850000,"deprecated":false,"name":"GrpE protein homolog 2, mitochondrial","accession":"Q8TAA5","gene":"GRPEL2","description":"Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.014240437087902656,"antibodyCount":83,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.069841,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.10252466823842,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12625)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(12625)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(12625)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12625)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12625)/publications"},"_namespace":null},{"id":12626,"version":3,"created":1554955781000,"modified":1555040851000,"deprecated":false,"name":"DNA repair endonuclease XPF","accession":"Q92889","gene":"ERCC4","description":"Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9148189905665347,"antibodyCount":286,"monoclonalCount":189,"pubmedCount":null,"jensenScore":69.196118,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":50.31143154484128,"pubTatorScore":2.3285561133687356,"self":"https://pharos.nih.gov/idg/api/v1/targets(12626)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":597,"href":"https://pharos.nih.gov/idg/api/v1/targets(12626)/properties"},"_links":{"count":1283,"href":"https://pharos.nih.gov/idg/api/v1/targets(12626)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12626)/synonyms"},"_publications":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(12626)/publications"},"_namespace":null},{"id":12627,"version":2,"created":1554955789000,"modified":1554955791000,"deprecated":false,"name":"Protein shisa-4","accession":"Q96DD7","gene":"SHISA4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.326904935405278,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12627)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(12627)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(12627)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12627)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12627)/publications"},"_namespace":null},{"id":12628,"version":2,"created":1554955792000,"modified":1554955796000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 1","accession":"Q92888","gene":"ARHGEF1","description":"Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9473714572078835,"antibodyCount":207,"monoclonalCount":32,"pubmedCount":null,"jensenScore":852.18698,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.35075528770417,"pubTatorScore":1.628887775538475,"self":"https://pharos.nih.gov/idg/api/v1/targets(12628)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(12628)/properties"},"_links":{"count":1135,"href":"https://pharos.nih.gov/idg/api/v1/targets(12628)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(12628)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12628)/publications"},"_namespace":null},{"id":12629,"version":2,"created":1554955797000,"modified":1554955802000,"deprecated":false,"name":"Canalicular multispecific organic anion transporter 1","accession":"Q92887","gene":"ABCC2","description":"Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.90203853101823,"antibodyCount":234,"monoclonalCount":98,"pubmedCount":null,"jensenScore":834.94992,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.09098462882237,"pubTatorScore":2.8827693063224227,"self":"https://pharos.nih.gov/idg/api/v1/targets(12629)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":639,"href":"https://pharos.nih.gov/idg/api/v1/targets(12629)/properties"},"_links":{"count":1144,"href":"https://pharos.nih.gov/idg/api/v1/targets(12629)/links"},"_synonyms":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12629)/synonyms"},"_publications":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(12629)/publications"},"_namespace":null},{"id":12630,"version":2,"created":1554955804000,"modified":1554955806000,"deprecated":false,"name":"Neurogenin-1","accession":"Q92886","gene":"NEUROG1","description":"Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1469622474714747,"antibodyCount":442,"monoclonalCount":228,"pubmedCount":null,"jensenScore":132.514221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.539363005777698,"pubTatorScore":1.8032365391083278,"self":"https://pharos.nih.gov/idg/api/v1/targets(12630)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(12630)/properties"},"_links":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(12630)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12630)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12630)/publications"},"_namespace":null},{"id":12631,"version":3,"created":1554955806000,"modified":1555040854000,"deprecated":false,"name":"Gamma-aminobutyric acid receptor subunit alpha-3","accession":"P34903","gene":"GABRA3","description":"GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.5376526228217167,"antibodyCount":135,"monoclonalCount":8,"pubmedCount":null,"jensenScore":32.930182,"patentCount":1104,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":31.95189779388256,"pubTatorScore":1.5595460708104367,"self":"https://pharos.nih.gov/idg/api/v1/targets(12631)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(12631)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(12631)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(12631)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12631)/publications"},"_namespace":null},{"id":12632,"version":2,"created":1554955908000,"modified":1554955913000,"deprecated":false,"name":"CUGBP Elav-like family member 1","accession":"Q92879","gene":"CELF1","description":"RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1241617554057792,"antibodyCount":261,"monoclonalCount":96,"pubmedCount":null,"jensenScore":146.592114,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.44326678373999,"pubTatorScore":2.0003133650185814,"self":"https://pharos.nih.gov/idg/api/v1/targets(12632)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(12632)/properties"},"_links":{"count":1290,"href":"https://pharos.nih.gov/idg/api/v1/targets(12632)/links"},"_synonyms":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(12632)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12632)/publications"},"_namespace":null},{"id":12633,"version":2,"created":1554955915000,"modified":1554955917000,"deprecated":false,"name":"Protein-lysine methyltransferase METTL21D","accession":"Q9H867","gene":"VCPKMT","description":"Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.3540169195787305,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.629009,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.695325451065315,"pubTatorScore":0.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(12633)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12633)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(12633)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12633)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12633)/publications"},"_namespace":null},{"id":12634,"version":3,"created":1554955918000,"modified":1555040855000,"deprecated":false,"name":"YY1-associated protein 1","accession":"Q9H869","gene":"YY1AP1","description":"Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7030524346717049,"antibodyCount":114,"monoclonalCount":7,"pubmedCount":null,"jensenScore":5.065069,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":29.659593896371955,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(12634)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(12634)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(12634)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12634)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12634)/publications"},"_namespace":null},{"id":12635,"version":2,"created":1554955922000,"modified":1554955929000,"deprecated":false,"name":"Cytochrome c oxidase subunit NDUFA4","accession":"O00483","gene":"NDUFA4","description":"Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.1998698906171563,"antibodyCount":97,"monoclonalCount":3,"pubmedCount":null,"jensenScore":14.32299,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.228442397396954,"pubTatorScore":1.0372816824092768,"self":"https://pharos.nih.gov/idg/api/v1/targets(12635)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(12635)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(12635)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12635)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12635)/publications"},"_namespace":null},{"id":12636,"version":2,"created":1554955929000,"modified":1554955932000,"deprecated":false,"name":"Zinc finger protein 593","accession":"O00488","gene":"ZNF593","description":"Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.0,"antibodyCount":62,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.27730203395064,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(12636)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(12636)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(12636)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12636)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12636)/publications"},"_namespace":null},{"id":12637,"version":2,"created":1554955933000,"modified":1554955936000,"deprecated":false,"name":"26S proteasome non-ATPase regulatory subunit 14","accession":"O00487","gene":"PSMD14","description":"Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.802550444589874,"antibodyCount":195,"monoclonalCount":42,"pubmedCount":null,"jensenScore":64.202185,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.134917498304866,"pubTatorScore":1.58099980238591,"self":"https://pharos.nih.gov/idg/api/v1/targets(12637)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":583,"href":"https://pharos.nih.gov/idg/api/v1/targets(12637)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12637)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(12637)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12637)/publications"},"_namespace":null},{"id":12638,"version":2,"created":1554955937000,"modified":1554955941000,"deprecated":false,"name":"Serine-rich coiled-coil domain-containing protein 2","accession":"Q9H7U1","gene":"CCSER2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.1613680037550056,"antibodyCount":24,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.34011983098721,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(12638)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(12638)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(12638)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12638)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12638)/publications"},"_namespace":null},{"id":12639,"version":2,"created":1554955941000,"modified":1554955942000,"deprecated":false,"name":"Putative coiled-coil domain-containing protein 195","accession":"A0A1B0GUA6","gene":"CCDC195","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12639)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12639)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12639)/links"},"_synonyms":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12639)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12639)/publications"},"_namespace":null},{"id":12640,"version":2,"created":1554955942000,"modified":1554955942000,"deprecated":false,"name":"Testis-expressed protein 51","accession":"A0A1B0GUA7","gene":"TEX51","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12640)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12640)/properties"},"_links":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12640)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12640)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12640)/publications"},"_namespace":null},{"id":12641,"version":3,"created":1554955942000,"modified":1555040857000,"deprecated":false,"name":"Amyloid-beta A4 precursor protein-binding family B member 2","accession":"Q92870","gene":"APBB2","description":"May modulate the internalization of amyloid-beta precursor protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0046373558591242,"antibodyCount":135,"monoclonalCount":8,"pubmedCount":null,"jensenScore":10.309544,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":47.71375014439944,"pubTatorScore":1.0274569243807221,"self":"https://pharos.nih.gov/idg/api/v1/targets(12641)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":407,"href":"https://pharos.nih.gov/idg/api/v1/targets(12641)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(12641)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12641)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12641)/publications"},"_namespace":null},{"id":12642,"version":2,"created":1554955947000,"modified":1554955949000,"deprecated":false,"name":"Beta-crystallin S","accession":"P22914","gene":"CRYGS","description":"Crystallins are the dominant structural components of the vertebrate eye lens.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.79704331168395,"antibodyCount":150,"monoclonalCount":3,"pubmedCount":null,"jensenScore":615.619109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.584304932910516,"pubTatorScore":1.6850279422949326,"self":"https://pharos.nih.gov/idg/api/v1/targets(12642)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(12642)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(12642)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12642)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12642)/publications"},"_namespace":null},{"id":12643,"version":3,"created":1554955950000,"modified":1555040859000,"deprecated":false,"name":"Deoxyribonuclease-1-like 2","accession":"Q92874","gene":"DNASE1L2","description":"Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.673134295372744,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.799593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.10314494824538,"pubTatorScore":1.1279527564403917,"self":"https://pharos.nih.gov/idg/api/v1/targets(12643)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(12643)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(12643)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12643)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12643)/publications"},"_namespace":null},{"id":12644,"version":2,"created":1554955953000,"modified":1554955955000,"deprecated":false,"name":"Ubiquitin thioesterase OTUB2","accession":"Q96DC9","gene":"OTUB2","description":"Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.019462479226564,"antibodyCount":252,"monoclonalCount":74,"pubmedCount":null,"jensenScore":11.001372,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.59202356689021,"pubTatorScore":1.0288035055955178,"self":"https://pharos.nih.gov/idg/api/v1/targets(12644)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(12644)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(12644)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12644)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12644)/publications"},"_namespace":null},{"id":12645,"version":2,"created":1554955956000,"modified":1554955960000,"deprecated":false,"name":"E3 ubiquitin-protein ligase Hakai","accession":"Q75N03","gene":"CBLL1","description":"Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1460541771535069,"antibodyCount":155,"monoclonalCount":26,"pubmedCount":null,"jensenScore":13.994027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.52826318212443,"pubTatorScore":1.0297701278737605,"self":"https://pharos.nih.gov/idg/api/v1/targets(12645)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(12645)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(12645)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12645)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12645)/publications"},"_namespace":null},{"id":12646,"version":3,"created":1554955961000,"modified":1555040860000,"deprecated":false,"name":"Phosphomannomutase 1","accession":"Q92871","gene":"PMM1","description":"Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6168144585701147,"antibodyCount":50,"monoclonalCount":3,"pubmedCount":null,"jensenScore":38.881044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":34.87152277890902,"pubTatorScore":1.1804126041720204,"self":"https://pharos.nih.gov/idg/api/v1/targets(12646)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(12646)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(12646)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12646)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12646)/publications"},"_namespace":null},{"id":12647,"version":3,"created":1554955964000,"modified":1555040861000,"deprecated":false,"name":"DNA repair protein RAD50","accession":"Q92878","gene":"RAD50","description":"Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4236879109386662,"antibodyCount":305,"monoclonalCount":62,"pubmedCount":null,"jensenScore":23.787728,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":53.013927514876784,"pubTatorScore":2.3443125841451677,"self":"https://pharos.nih.gov/idg/api/v1/targets(12647)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":685,"href":"https://pharos.nih.gov/idg/api/v1/targets(12647)/properties"},"_links":{"count":1248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12647)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12647)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(12647)/publications"},"_namespace":null},{"id":12648,"version":2,"created":1554955972000,"modified":1554955975000,"deprecated":false,"name":"Enoyl-CoA hydratase domain-containing protein 3, mitochondrial","accession":"Q96DC8","gene":"ECHDC3","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.3321177094672506,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.802174,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.28658595995523,"pubTatorScore":-0.17214242027506393,"self":"https://pharos.nih.gov/idg/api/v1/targets(12648)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(12648)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(12648)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12648)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12648)/publications"},"_namespace":null},{"id":12649,"version":3,"created":1554955976000,"modified":1555040863000,"deprecated":false,"name":"Kallikrein-6","accession":"Q92876","gene":"KLK6","description":"Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.130366450384441,"antibodyCount":238,"monoclonalCount":39,"pubmedCount":null,"jensenScore":151.452848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":28.637388442038635,"pubTatorScore":2.155014762446832,"self":"https://pharos.nih.gov/idg/api/v1/targets(12649)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(12649)/properties"},"_links":{"count":841,"href":"https://pharos.nih.gov/idg/api/v1/targets(12649)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12649)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12649)/publications"},"_namespace":null},{"id":12650,"version":2,"created":1554955981000,"modified":1554955983000,"deprecated":false,"name":"Fibroblast growth factor 4","accession":"P08620","gene":"FGF4","description":"Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6038843803928406,"antibodyCount":327,"monoclonalCount":63,"pubmedCount":null,"jensenScore":394.054838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.30669553981389,"pubTatorScore":2.4027024995876984,"self":"https://pharos.nih.gov/idg/api/v1/targets(12650)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(12650)/properties"},"_links":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(12650)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12650)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(12650)/publications"},"_namespace":null},{"id":12651,"version":2,"created":1554955983000,"modified":1554955983000,"deprecated":false,"name":"Olfactory receptor 5AL1","accession":"P0C617","gene":"OR5AL1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.322283686764133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12651)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(12651)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12651)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12651)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12651)/publications"},"_namespace":null},{"id":12652,"version":3,"created":1554955984000,"modified":1555040866000,"deprecated":false,"name":"U1 small nuclear ribonucleoprotein 70 kDa","accession":"P08621","gene":"SNRNP70","description":"Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6858082341778093,"antibodyCount":144,"monoclonalCount":10,"pubmedCount":null,"jensenScore":440.920119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":73,"knowledgeAvailability":46.023894493854385,"pubTatorScore":2.5411371980501087,"self":"https://pharos.nih.gov/idg/api/v1/targets(12652)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(12652)/properties"},"_links":{"count":1223,"href":"https://pharos.nih.gov/idg/api/v1/targets(12652)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(12652)/synonyms"},"_publications":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12652)/publications"},"_namespace":null},{"id":12653,"version":3,"created":1554955989000,"modified":1555040868000,"deprecated":false,"name":"Transmembrane and coiled-coil domain-containing protein 6","accession":"Q96DC7","gene":"TMCO6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":47,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.865666100930003,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12653)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(12653)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(12653)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12653)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12653)/publications"},"_namespace":null},{"id":12654,"version":3,"created":1554955994000,"modified":1555040869000,"deprecated":false,"name":"Aurora kinase A and ninein-interacting protein","accession":"Q9H7T9","gene":"AUNIP","description":"DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.12493873552256378,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.835165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.726952562029297,"pubTatorScore":0.3679767232525211,"self":"https://pharos.nih.gov/idg/api/v1/targets(12654)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(12654)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(12654)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12654)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12654)/publications"},"_namespace":null},{"id":12655,"version":3,"created":1554955996000,"modified":1555040871000,"deprecated":false,"name":"Furin","accession":"P09958","gene":"FURIN","description":"(Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins. Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.102125596207249,"antibodyCount":260,"monoclonalCount":56,"pubmedCount":null,"jensenScore":1183.47678,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":49.74252538506708,"pubTatorScore":2.8935279083490104,"self":"https://pharos.nih.gov/idg/api/v1/targets(12655)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":632,"href":"https://pharos.nih.gov/idg/api/v1/targets(12655)/properties"},"_links":{"count":1326,"href":"https://pharos.nih.gov/idg/api/v1/targets(12655)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(12655)/synonyms"},"_publications":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(12655)/publications"},"_namespace":null},{"id":12656,"version":2,"created":1554956026000,"modified":1554956029000,"deprecated":false,"name":"5'-nucleotidase domain-containing protein 2","accession":"Q9H857","gene":"NT5DC2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.6232492903979004,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.225491,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.49969916911156,"pubTatorScore":-1.1461254299191639,"self":"https://pharos.nih.gov/idg/api/v1/targets(12656)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(12656)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(12656)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12656)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12656)/publications"},"_namespace":null},{"id":12657,"version":3,"created":1554956030000,"modified":1555040873000,"deprecated":false,"name":"Glutamate receptor ionotropic, NMDA 1","accession":"Q05586","gene":"GRIN1","description":"Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.8457404020810997,"antibodyCount":873,"monoclonalCount":134,"pubmedCount":null,"jensenScore":693.122315,"patentCount":41465,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.5450761217745,"pubTatorScore":2.87624319467952,"self":"https://pharos.nih.gov/idg/api/v1/targets(12657)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":666,"href":"https://pharos.nih.gov/idg/api/v1/targets(12657)/properties"},"_links":{"count":1193,"href":"https://pharos.nih.gov/idg/api/v1/targets(12657)/links"},"_synonyms":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(12657)/synonyms"},"_publications":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(12657)/publications"},"_namespace":null},{"id":12658,"version":2,"created":1554956073000,"modified":1554956074000,"deprecated":false,"name":"Lymphocyte antigen 6 complex locus protein G6f","accession":"Q5SQ64","gene":"LY6G6F","description":"May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.607369901587076,"antibodyCount":114,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.618649,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.249091767753876,"pubTatorScore":0.28469912384860285,"self":"https://pharos.nih.gov/idg/api/v1/targets(12658)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12658)/properties"},"_links":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12658)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(12658)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12658)/publications"},"_namespace":null},{"id":12659,"version":2,"created":1554956074000,"modified":1554956075000,"deprecated":false,"name":"Uncharacterized protein C10orf95","accession":"Q9H7T3","gene":"C10orf95","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12659)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12659)/properties"},"_links":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(12659)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12659)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12659)/publications"},"_namespace":null},{"id":12660,"version":2,"created":1554956075000,"modified":1554956076000,"deprecated":false,"name":"Putative tubulin-like protein alpha-4B","accession":"Q9H853","gene":"TUBA4B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.655923323986972,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12660)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(12660)/properties"},"_links":{"count":618,"href":"https://pharos.nih.gov/idg/api/v1/targets(12660)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12660)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12660)/publications"},"_namespace":null},{"id":12661,"version":2,"created":1554956077000,"modified":1554956083000,"deprecated":false,"name":"Myc box-dependent-interacting protein 1","accession":"O00499","gene":"BIN1","description":"May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.342425981472811,"antibodyCount":285,"monoclonalCount":99,"pubmedCount":null,"jensenScore":223.270853,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.12304740760231,"pubTatorScore":2.212771441780573,"self":"https://pharos.nih.gov/idg/api/v1/targets(12661)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(12661)/properties"},"_links":{"count":1546,"href":"https://pharos.nih.gov/idg/api/v1/targets(12661)/links"},"_synonyms":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(12661)/synonyms"},"_publications":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(12661)/publications"},"_namespace":null},{"id":12662,"version":2,"created":1554956084000,"modified":1554956087000,"deprecated":false,"name":"Cation channel sperm-associated protein subunit beta","accession":"Q9H7T0","gene":"CATSPERB","description":"Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.0731070996383151,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.046003,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.440550014749466,"pubTatorScore":0.1879905762568884,"self":"https://pharos.nih.gov/idg/api/v1/targets(12662)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12662)/properties"},"_links":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(12662)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12662)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12662)/publications"},"_namespace":null},{"id":12663,"version":2,"created":1554956088000,"modified":1554956088000,"deprecated":false,"name":"Olfactory receptor 5G3","accession":"P0C626","gene":"OR5G3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.322283686764133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12663)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12663)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12663)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12663)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12663)/publications"},"_namespace":null},{"id":12664,"version":4,"created":1554956088000,"modified":1555040875000,"deprecated":false,"name":"Histone deacetylase 11","accession":"Q96DB2","gene":"HDAC11","description":"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-2.2788763933603877,"antibodyCount":353,"monoclonalCount":58,"pubmedCount":null,"jensenScore":181.524398,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":33.38253177992326,"pubTatorScore":1.653829352735838,"self":"https://pharos.nih.gov/idg/api/v1/targets(12664)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(12664)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(12664)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12664)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12664)/publications"},"_namespace":null},{"id":12665,"version":2,"created":1554956099000,"modified":1554956099000,"deprecated":false,"name":"Olfactory receptor 4Q2","accession":"P0C623","gene":"OR4Q2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.514954417601629,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12665)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(12665)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12665)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12665)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12665)/publications"},"_namespace":null},{"id":12666,"version":3,"created":1554956099000,"modified":1554956235000,"deprecated":false,"name":"Leukotriene A-4 hydrolase","accession":"P09960","gene":"LTA4H","description":"Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.1115093638218307,"antibodyCount":291,"monoclonalCount":119,"pubmedCount":null,"jensenScore":125.34675,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.031196184393536,"pubTatorScore":2.392512848988424,"self":"https://pharos.nih.gov/idg/api/v1/targets(12666)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(12666)/properties"},"_links":{"count":1586,"href":"https://pharos.nih.gov/idg/api/v1/targets(12666)/links"},"_synonyms":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(12666)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12666)/publications"},"_namespace":null},{"id":12667,"version":2,"created":1554956237000,"modified":1554956240000,"deprecated":false,"name":"FXYD domain-containing ion transport regulator 5","accession":"Q96DB9","gene":"FXYD5","description":"Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.6354358728299925,"antibodyCount":173,"monoclonalCount":0,"pubmedCount":null,"jensenScore":427.604085,"patentCount":14029,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.080027290730904,"pubTatorScore":1.800340473806295,"self":"https://pharos.nih.gov/idg/api/v1/targets(12667)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(12667)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(12667)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12667)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12667)/publications"},"_namespace":null},{"id":12668,"version":2,"created":1554956241000,"modified":1554956245000,"deprecated":false,"name":"Regulator of microtubule dynamics protein 1","accession":"Q96DB5","gene":"RMDN1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.827403241727634,"pubTatorScore":2.479162116467996,"self":"https://pharos.nih.gov/idg/api/v1/targets(12668)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(12668)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(12668)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12668)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12668)/publications"},"_namespace":null},{"id":12669,"version":2,"created":1554956246000,"modified":1554956246000,"deprecated":false,"name":"Olfactory receptor 10J4","accession":"P0C629","gene":"OR10J4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.322283686764133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(12669)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12669)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12669)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12669)/publications"},"_namespace":null},{"id":12670,"version":2,"created":1554956246000,"modified":1554956261000,"deprecated":false,"name":"Tyrosine-protein kinase HCK","accession":"P08631","gene":"HCK","description":"Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.5351678021500317,"antibodyCount":428,"monoclonalCount":75,"pubmedCount":null,"jensenScore":3192.674323,"patentCount":25283,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.07972319798772,"pubTatorScore":2.258626255239071,"self":"https://pharos.nih.gov/idg/api/v1/targets(12670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":551,"href":"https://pharos.nih.gov/idg/api/v1/targets(12670)/properties"},"_links":{"count":1321,"href":"https://pharos.nih.gov/idg/api/v1/targets(12670)/links"},"_synonyms":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(12670)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(12670)/publications"},"_namespace":null},{"id":12671,"version":2,"created":1554956263000,"modified":1554956263000,"deprecated":false,"name":"Olfactory receptor 5AC1","accession":"P0C628","gene":"OR5AC1","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.322283686764133,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12671)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12671)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12671)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12671)/publications"},"_namespace":null},{"id":12672,"version":3,"created":1554956263000,"modified":1555040877000,"deprecated":false,"name":"EP300-interacting inhibitor of differentiation 2B","accession":"Q96D98","gene":"EID2B","description":"Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3869446243705744,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.455556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.516260773793512,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12672)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12672)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(12672)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12672)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12672)/publications"},"_namespace":null},{"id":12673,"version":2,"created":1554956266000,"modified":1554956269000,"deprecated":false,"name":"Uncharacterized protein KIAA1614","accession":"Q5VZ46","gene":"KIAA1614","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0434656946083179,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.910256,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.658273141901454,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12673)/properties"},"_links":{"count":859,"href":"https://pharos.nih.gov/idg/api/v1/targets(12673)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(12673)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12673)/publications"},"_namespace":null},{"id":12674,"version":3,"created":1554956269000,"modified":1555040877000,"deprecated":false,"name":"Insulin-like growth factor 2 mRNA-binding protein 3","accession":"O00425","gene":"IGF2BP3","description":"RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2110479185269885,"antibodyCount":233,"monoclonalCount":62,"pubmedCount":null,"jensenScore":164.823804,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.103361478707086,"pubTatorScore":2.002250635072372,"self":"https://pharos.nih.gov/idg/api/v1/targets(12674)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(12674)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(12674)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12674)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(12674)/publications"},"_namespace":null},{"id":12675,"version":2,"created":1554956275000,"modified":1554956275000,"deprecated":false,"name":"Putative small proline-rich protein 5","accession":"A0A1B0GTR4","gene":"SPRR5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12675)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12675)/properties"},"_links":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12675)/links"},"_synonyms":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12675)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12675)/publications"},"_namespace":null},{"id":12676,"version":2,"created":1554956275000,"modified":1554956277000,"deprecated":false,"name":"Mesenteric estrogen-dependent adipogenesis protein","accession":"Q5VYS4","gene":"MEDAG","description":"Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6681599251345347,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.997619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.815049408175675,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(12676)/properties"},"_links":{"count":748,"href":"https://pharos.nih.gov/idg/api/v1/targets(12676)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12676)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12676)/publications"},"_namespace":null},{"id":12677,"version":3,"created":1554956278000,"modified":1555040879000,"deprecated":false,"name":"Zinc finger protein 501","accession":"Q96CX3","gene":"ZNF501","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-1.602156762919286,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.118799,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":23.17029486164551,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(12677)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(12677)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12677)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12677)/publications"},"_namespace":null},{"id":12678,"version":2,"created":1554956282000,"modified":1554956286000,"deprecated":false,"name":"Dynamin-1-like protein","accession":"O00429","gene":"DNM1L","description":"Isoform 4: Inhibits peroxisomal division when overexpressed.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.657174796344514,"antibodyCount":426,"monoclonalCount":144,"pubmedCount":null,"jensenScore":476.89765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.295138863419105,"pubTatorScore":2.375458298663984,"self":"https://pharos.nih.gov/idg/api/v1/targets(12678)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(12678)/properties"},"_links":{"count":1433,"href":"https://pharos.nih.gov/idg/api/v1/targets(12678)/links"},"_synonyms":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(12678)/synonyms"},"_publications":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(12678)/publications"},"_namespace":null},{"id":12679,"version":2,"created":1554956288000,"modified":1554956291000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 58","accession":"Q96CX6","gene":"LRRC58","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9747832118358422,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.13,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.604185824509283,"pubTatorScore":-1.230445447036316,"self":"https://pharos.nih.gov/idg/api/v1/targets(12679)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(12679)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(12679)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12679)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12679)/publications"},"_namespace":null},{"id":12680,"version":3,"created":1554956291000,"modified":1555040880000,"deprecated":false,"name":"Polypeptide N-acetylgalactosaminyltransferase 5","accession":"Q7Z7M9","gene":"GALNT5","description":"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4036923398773662,"antibodyCount":93,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.614286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.640245457294707,"pubTatorScore":0.505149978319906,"self":"https://pharos.nih.gov/idg/api/v1/targets(12680)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(12680)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(12680)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12680)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12680)/publications"},"_namespace":null},{"id":12681,"version":2,"created":1554956295000,"modified":1554956296000,"deprecated":false,"name":"Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial","accession":"Q5T1J5","gene":"CHCHD2P9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3381330073937172,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.812514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.169577158425181,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12681)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(12681)/properties"},"_links":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(12681)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12681)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12681)/publications"},"_namespace":null},{"id":12682,"version":3,"created":1554956296000,"modified":1555040881000,"deprecated":false,"name":"Prolactin-releasing peptide","accession":"P81277","gene":"PRLH","description":"Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.067764756893167,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":143.660722,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":16.048693058781495,"pubTatorScore":1.7718471715810795,"self":"https://pharos.nih.gov/idg/api/v1/targets(12682)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12682)/properties"},"_links":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(12682)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12682)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12682)/publications"},"_namespace":null},{"id":12683,"version":3,"created":1554956297000,"modified":1555040881000,"deprecated":false,"name":"Voltage-gated hydrogen channel 1","accession":"Q96D96","gene":"HVCN1","description":"Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.6821517775893877,"antibodyCount":110,"monoclonalCount":0,"pubmedCount":null,"jensenScore":486.108815,"patentCount":12881,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":29.136795424167587,"pubTatorScore":2.3588545235110936,"self":"https://pharos.nih.gov/idg/api/v1/targets(12683)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(12683)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(12683)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12683)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12683)/publications"},"_namespace":null},{"id":12684,"version":2,"created":1554956301000,"modified":1554956303000,"deprecated":false,"name":"Epididymal protein 13","accession":"A0A1B0GTR0","gene":"EDDM13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12684)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12684)/properties"},"_links":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(12684)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12684)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12684)/publications"},"_namespace":null},{"id":12685,"version":2,"created":1554956303000,"modified":1554956306000,"deprecated":false,"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8","accession":"Q7Z7M8","gene":"B3GNT8","description":"Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.0,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.911128026343086,"pubTatorScore":1.1260230962399467,"self":"https://pharos.nih.gov/idg/api/v1/targets(12685)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(12685)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(12685)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12685)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12685)/publications"},"_namespace":null},{"id":12686,"version":2,"created":1554956307000,"modified":1554956310000,"deprecated":false,"name":"Terminal uridylyltransferase 7","accession":"Q5VYS8","gene":"ZCCHC6","description":"Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.199147638069667,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.114467,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.295503577104895,"pubTatorScore":1.0569048513364727,"self":"https://pharos.nih.gov/idg/api/v1/targets(12686)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(12686)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(12686)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12686)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12686)/publications"},"_namespace":null},{"id":12687,"version":2,"created":1554956311000,"modified":1554956312000,"deprecated":false,"name":"Protein FAM182A","accession":"Q5T1J6","gene":"FAM182A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.387147394526616,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12687)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12687)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12687)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12687)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12687)/publications"},"_namespace":null},{"id":12688,"version":2,"created":1554956312000,"modified":1554956316000,"deprecated":false,"name":"G-protein-signaling modulator 2","accession":"P81274","gene":"GPSM2","description":"Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9238148394009205,"antibodyCount":138,"monoclonalCount":0,"pubmedCount":null,"jensenScore":834.60778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.437441027883196,"pubTatorScore":1.8812547656067757,"self":"https://pharos.nih.gov/idg/api/v1/targets(12688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12688)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(12688)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12688)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(12688)/publications"},"_namespace":null},{"id":12689,"version":3,"created":1554956317000,"modified":1555040884000,"deprecated":false,"name":"Histone deacetylase complex subunit SAP18","accession":"O00422","gene":"SAP18","description":"Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1860922460728849,"antibodyCount":125,"monoclonalCount":10,"pubmedCount":null,"jensenScore":14.588026,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":40.60046022708913,"pubTatorScore":0.9891218816469652,"self":"https://pharos.nih.gov/idg/api/v1/targets(12689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(12689)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12689)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12689)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12689)/publications"},"_namespace":null},{"id":12690,"version":3,"created":1554956322000,"modified":1555040885000,"deprecated":false,"name":"C-C chemokine receptor-like 2","accession":"O00421","gene":"CCRL2","description":"Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.2430094513362184,"antibodyCount":281,"monoclonalCount":94,"pubmedCount":null,"jensenScore":18.924741,"patentCount":50713,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":30.276875071606188,"pubTatorScore":2.0021665846381063,"self":"https://pharos.nih.gov/idg/api/v1/targets(12690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(12690)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(12690)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12690)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12690)/publications"},"_namespace":null},{"id":12691,"version":2,"created":1554956356000,"modified":1554956358000,"deprecated":false,"name":"Adhesion G-protein coupled receptor D2","accession":"Q7Z7M1","gene":"ADGRD2","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":0.3241235011893167,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.359852,"patentCount":256,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.496029904267953,"pubTatorScore":-0.6011073262894893,"self":"https://pharos.nih.gov/idg/api/v1/targets(12691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12691)/properties"},"_links":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(12691)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12691)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12691)/publications"},"_namespace":null},{"id":12692,"version":2,"created":1554956358000,"modified":1554956362000,"deprecated":false,"name":"Multiple epidermal growth factor-like domains protein 8","accession":"Q7Z7M0","gene":"MEGF8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.21967182703249077,"antibodyCount":58,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.878788,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.241180762038944,"pubTatorScore":0.25527226382852686,"self":"https://pharos.nih.gov/idg/api/v1/targets(12692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(12692)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(12692)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12692)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12692)/publications"},"_namespace":null},{"id":12693,"version":3,"created":1554956363000,"modified":1555040886000,"deprecated":false,"name":"Echinoderm microtubule-associated protein-like 1","accession":"O00423","gene":"EML1","description":"Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.080668207253597,"antibodyCount":64,"monoclonalCount":10,"pubmedCount":null,"jensenScore":119.531485,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":34.673140377211446,"pubTatorScore":1.5609640222642671,"self":"https://pharos.nih.gov/idg/api/v1/targets(12693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(12693)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(12693)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(12693)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12693)/publications"},"_namespace":null},{"id":12694,"version":2,"created":1554956368000,"modified":1554956370000,"deprecated":false,"name":"Synaptotagmin-10","accession":"Q6XYQ8","gene":"SYT10","description":"Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.861501234503325,"antibodyCount":115,"monoclonalCount":56,"pubmedCount":null,"jensenScore":6.370265,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.48470122878474,"pubTatorScore":0.6450946563301051,"self":"https://pharos.nih.gov/idg/api/v1/targets(12694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(12694)/properties"},"_links":{"count":621,"href":"https://pharos.nih.gov/idg/api/v1/targets(12694)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12694)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12694)/publications"},"_namespace":null},{"id":12695,"version":2,"created":1554956370000,"modified":1554956371000,"deprecated":false,"name":"Embryonic stem cell-related gene protein","accession":"Q1W209","gene":"ESRG","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.0241782444231475,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(12695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12695)/properties"},"_links":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12695)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12695)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12695)/publications"},"_namespace":null},{"id":12696,"version":3,"created":1554956371000,"modified":1555040888000,"deprecated":false,"name":"BTB/POZ domain-containing protein KCTD12","accession":"Q96CX2","gene":"KCTD12","description":"Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.383722825949135,"antibodyCount":103,"monoclonalCount":3,"pubmedCount":null,"jensenScore":26.162088,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":40.4739169350884,"pubTatorScore":1.3286148946755385,"self":"https://pharos.nih.gov/idg/api/v1/targets(12696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(12696)/properties"},"_links":{"count":980,"href":"https://pharos.nih.gov/idg/api/v1/targets(12696)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12696)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12696)/publications"},"_namespace":null},{"id":12697,"version":2,"created":1554956376000,"modified":1554956384000,"deprecated":false,"name":"Nuclear factor erythroid 2-related factor 2","accession":"Q16236","gene":"NFE2L2","description":"Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.1428424629722995,"antibodyCount":552,"monoclonalCount":87,"pubmedCount":null,"jensenScore":1506.686818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":51.73621963590786,"pubTatorScore":3.2601100890576866,"self":"https://pharos.nih.gov/idg/api/v1/targets(12697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1415,"href":"https://pharos.nih.gov/idg/api/v1/targets(12697)/properties"},"_links":{"count":2080,"href":"https://pharos.nih.gov/idg/api/v1/targets(12697)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(12697)/synonyms"},"_publications":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(12697)/publications"},"_namespace":null},{"id":12698,"version":2,"created":1554956388000,"modified":1554956388000,"deprecated":false,"name":"Small integral membrane protein 28","accession":"A0A1B0GU29","gene":"SMIM28","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12698)/properties"},"_links":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(12698)/links"},"_synonyms":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12698)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12698)/publications"},"_namespace":null},{"id":12699,"version":2,"created":1554956388000,"modified":1554956391000,"deprecated":false,"name":"Probable RNA polymerase II nuclear localization protein SLC7A6OS","accession":"Q96CW6","gene":"SLC7A6OS","description":"Directs RNA polymerase II nuclear import.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.30871682448537735,"antibodyCount":8,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.339459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.048496743815928,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(12699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(12699)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(12699)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12699)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12699)/publications"},"_namespace":null},{"id":12700,"version":2,"created":1554956391000,"modified":1554956395000,"deprecated":false,"name":"Schlafen family member 11","accession":"Q7Z7L1","gene":"SLFN11","description":"Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2419839499304057,"antibodyCount":21,"monoclonalCount":2,"pubmedCount":null,"jensenScore":19.129737,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.125782527941805,"pubTatorScore":0.992299051880374,"self":"https://pharos.nih.gov/idg/api/v1/targets(12700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12700)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(12700)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12700)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12700)/publications"},"_namespace":null},{"id":12701,"version":2,"created":1554956396000,"modified":1554956399000,"deprecated":false,"name":"Netrin-G2","accession":"Q96CW9","gene":"NTNG2","description":"Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2356854536310207,"antibodyCount":79,"monoclonalCount":48,"pubmedCount":null,"jensenScore":19.943515,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.556825165761797,"pubTatorScore":0.9081018665188841,"self":"https://pharos.nih.gov/idg/api/v1/targets(12701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(12701)/properties"},"_links":{"count":770,"href":"https://pharos.nih.gov/idg/api/v1/targets(12701)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12701)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12701)/publications"},"_namespace":null},{"id":12702,"version":2,"created":1554956400000,"modified":1554956403000,"deprecated":false,"name":"Protein phosphatase 1 regulatory subunit 3E","accession":"Q9H7J1","gene":"PPP1R3E","description":"Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.215528118680457,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(12702)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(12702)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12702)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12702)/publications"},"_namespace":null},{"id":12703,"version":3,"created":1554956404000,"modified":1555040889000,"deprecated":false,"name":"Gamma-tubulin complex component 3","accession":"Q96CW5","gene":"TUBGCP3","description":"Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4346259150068972,"antibodyCount":160,"monoclonalCount":2,"pubmedCount":null,"jensenScore":27.904311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.09977968737695,"pubTatorScore":0.9482624527494921,"self":"https://pharos.nih.gov/idg/api/v1/targets(12703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(12703)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(12703)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12703)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12703)/publications"},"_namespace":null},{"id":12704,"version":2,"created":1554956409000,"modified":1554956412000,"deprecated":false,"name":"Uncharacterized protein C11orf96","accession":"Q7Z7L8","gene":"C11orf96","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.1094660274497872,"self":"https://pharos.nih.gov/idg/api/v1/targets(12704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(12704)/properties"},"_links":{"count":809,"href":"https://pharos.nih.gov/idg/api/v1/targets(12704)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12704)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12704)/publications"},"_namespace":null},{"id":12705,"version":2,"created":1554956412000,"modified":1554956413000,"deprecated":false,"name":"Protein GDF5OS, mitochondrial","accession":"Q5U4N7","gene":"GDF5OS","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.5200311965243722,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12705)/properties"},"_links":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(12705)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12705)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12705)/publications"},"_namespace":null},{"id":12706,"version":2,"created":1554956414000,"modified":1554956414000,"deprecated":false,"name":"Heat shock transcription factor, X-linked member 4","accession":"A0A1B0GTS1","gene":"HSFX4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12706)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12706)/properties"},"_links":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12706)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(12706)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12706)/publications"},"_namespace":null},{"id":12707,"version":2,"created":1554956414000,"modified":1554956417000,"deprecated":false,"name":"Protein zer-1 homolog","accession":"Q7Z7L7","gene":"ZER1","description":"Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1795042923695018,"antibodyCount":55,"monoclonalCount":3,"pubmedCount":null,"jensenScore":15.59913,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.621037198518145,"pubTatorScore":0.08517172872158552,"self":"https://pharos.nih.gov/idg/api/v1/targets(12707)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(12707)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(12707)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12707)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12707)/publications"},"_namespace":null},{"id":12708,"version":2,"created":1554956418000,"modified":1554956421000,"deprecated":false,"name":"Deoxynucleotidyltransferase terminal-interacting protein 2","accession":"Q5QJE6","gene":"DNTTIP2","description":"Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.4249269810792677,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.861771,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.02399061495103,"pubTatorScore":1.268213816831426,"self":"https://pharos.nih.gov/idg/api/v1/targets(12708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(12708)/properties"},"_links":{"count":982,"href":"https://pharos.nih.gov/idg/api/v1/targets(12708)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12708)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12708)/publications"},"_namespace":null},{"id":12709,"version":3,"created":1554956421000,"modified":1555040890000,"deprecated":false,"name":"MORN repeat-containing protein 5","accession":"Q5VZ52","gene":"MORN5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.12493873660829995,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.85,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":17.610452866632258,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12709)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12709)/properties"},"_links":{"count":613,"href":"https://pharos.nih.gov/idg/api/v1/targets(12709)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12709)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12709)/publications"},"_namespace":null},{"id":12710,"version":2,"created":1554956424000,"modified":1554956427000,"deprecated":false,"name":"Zinc finger and SCAN domain-containing protein 2","accession":"Q7Z7L9","gene":"ZSCAN2","description":"May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.17609125688420882,"antibodyCount":98,"monoclonalCount":5,"pubmedCount":null,"jensenScore":1.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.561365944870246,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12710)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(12710)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(12710)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12710)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12710)/publications"},"_namespace":null},{"id":12711,"version":3,"created":1554956427000,"modified":1555040893000,"deprecated":false,"name":"AP-2 complex subunit mu","accession":"Q96CW1","gene":"AP2M1","description":"Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.610683268170918,"antibodyCount":345,"monoclonalCount":62,"pubmedCount":null,"jensenScore":397.139371,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":63,"knowledgeAvailability":47.72397028931318,"pubTatorScore":1.5648890592181162,"self":"https://pharos.nih.gov/idg/api/v1/targets(12711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":422,"href":"https://pharos.nih.gov/idg/api/v1/targets(12711)/properties"},"_links":{"count":1205,"href":"https://pharos.nih.gov/idg/api/v1/targets(12711)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12711)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12711)/publications"},"_namespace":null},{"id":12712,"version":2,"created":1554956433000,"modified":1554956436000,"deprecated":false,"name":"Protein eyes shut homolog","accession":"Q5T1H1","gene":"EYS","description":"Required to maintain the integrity of photoreceptor cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.090790688955766,"antibodyCount":24,"monoclonalCount":18,"pubmedCount":null,"jensenScore":119.936318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.625027217921442,"pubTatorScore":2.0290628900745533,"self":"https://pharos.nih.gov/idg/api/v1/targets(12712)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(12712)/properties"},"_links":{"count":791,"href":"https://pharos.nih.gov/idg/api/v1/targets(12712)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(12712)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12712)/publications"},"_namespace":null},{"id":12713,"version":2,"created":1554956437000,"modified":1554956439000,"deprecated":false,"name":"COX assembly mitochondrial protein homolog","accession":"Q7Z7K0","gene":"CMC1","description":"Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.526359196069517,"pubTatorScore":1.51410479881495,"self":"https://pharos.nih.gov/idg/api/v1/targets(12713)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(12713)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(12713)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12713)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12713)/publications"},"_namespace":null},{"id":12714,"version":2,"created":1554956440000,"modified":1554956443000,"deprecated":false,"name":"Zinc finger protein 467","accession":"Q7Z7K2","gene":"ZNF467","description":"Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.9848308142357125,"antibodyCount":9,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.92855,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.896249545057742,"pubTatorScore":0.301029778516686,"self":"https://pharos.nih.gov/idg/api/v1/targets(12714)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(12714)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(12714)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12714)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12714)/publications"},"_namespace":null},{"id":12715,"version":3,"created":1554956444000,"modified":1555040894000,"deprecated":false,"name":"RalBP1-associated Eps domain-containing protein 1","accession":"Q96D71","gene":"REPS1","description":"May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8839316738335061,"antibodyCount":53,"monoclonalCount":5,"pubmedCount":null,"jensenScore":7.902527,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.42584788959302,"pubTatorScore":0.8553171647964544,"self":"https://pharos.nih.gov/idg/api/v1/targets(12715)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(12715)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(12715)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12715)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12715)/publications"},"_namespace":null},{"id":12716,"version":2,"created":1554956448000,"modified":1554956451000,"deprecated":false,"name":"Centromere protein V","accession":"Q7Z7K6","gene":"CENPV","description":"Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6522193330692967,"antibodyCount":56,"monoclonalCount":22,"pubmedCount":null,"jensenScore":440.005802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.964282534590367,"pubTatorScore":2.644694458293896,"self":"https://pharos.nih.gov/idg/api/v1/targets(12716)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(12716)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(12716)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12716)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12716)/publications"},"_namespace":null},{"id":12717,"version":3,"created":1554956452000,"modified":1555040896000,"deprecated":false,"name":"RNA 3'-terminal phosphate cyclase","accession":"O00442","gene":"RTCA","description":"Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0354740276225867,"antibodyCount":95,"monoclonalCount":2,"pubmedCount":null,"jensenScore":99.9889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.37160569828017,"pubTatorScore":1.5685928003121639,"self":"https://pharos.nih.gov/idg/api/v1/targets(12717)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(12717)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(12717)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12717)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12717)/publications"},"_namespace":null},{"id":12718,"version":2,"created":1554956457000,"modified":1554956483000,"deprecated":false,"name":"Serine/threonine-protein kinase PLK4","accession":"O00444","gene":"PLK4","description":"Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.2722676629096714,"antibodyCount":130,"monoclonalCount":22,"pubmedCount":null,"jensenScore":200.815248,"patentCount":22179,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.44448229170644,"pubTatorScore":2.030429062920601,"self":"https://pharos.nih.gov/idg/api/v1/targets(12718)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(12718)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(12718)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(12718)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12718)/publications"},"_namespace":null},{"id":12719,"version":3,"created":1554956485000,"modified":1555040897000,"deprecated":false,"name":"Optineurin","accession":"Q96CV9","gene":"OPTN","description":"(Microbial infection) May constitute a cellular target for adenovirus E3 14.7 and Bluetongue virus protein NS3 to inhibit innate immune response.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.208470750483808,"antibodyCount":247,"monoclonalCount":8,"pubmedCount":null,"jensenScore":1590.613744,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":53.089202120662165,"pubTatorScore":2.6040973467260224,"self":"https://pharos.nih.gov/idg/api/v1/targets(12719)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":642,"href":"https://pharos.nih.gov/idg/api/v1/targets(12719)/properties"},"_links":{"count":1507,"href":"https://pharos.nih.gov/idg/api/v1/targets(12719)/links"},"_synonyms":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(12719)/synonyms"},"_publications":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(12719)/publications"},"_namespace":null},{"id":12720,"version":2,"created":1554956493000,"modified":1554956498000,"deprecated":false,"name":"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha","accession":"O00443","gene":"PIK3C2A","description":"Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.503984160910138,"antibodyCount":525,"monoclonalCount":343,"pubmedCount":null,"jensenScore":3128.971517,"patentCount":24803,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.29011908525498,"pubTatorScore":3.0559640964693178,"self":"https://pharos.nih.gov/idg/api/v1/targets(12720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(12720)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12720)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(12720)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12720)/publications"},"_namespace":null},{"id":12721,"version":3,"created":1554956500000,"modified":1555040899000,"deprecated":false,"name":"Synaptotagmin-5","accession":"O00445","gene":"SYT5","description":"May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8813766412015789,"antibodyCount":127,"monoclonalCount":24,"pubmedCount":null,"jensenScore":6.660894,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":30.181040091872074,"pubTatorScore":0.8414907402139317,"self":"https://pharos.nih.gov/idg/api/v1/targets(12721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(12721)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(12721)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12721)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12721)/publications"},"_namespace":null},{"id":12722,"version":2,"created":1554956504000,"modified":1554956506000,"deprecated":false,"name":"R3H domain-containing protein 4","accession":"Q96D70","gene":"R3HDM4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":30,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.00031626910313,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(12722)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(12722)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12722)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12722)/publications"},"_namespace":null},{"id":12723,"version":3,"created":1554956507000,"modified":1555040900000,"deprecated":false,"name":"Transcription factor E2F4","accession":"Q16254","gene":"E2F4","description":"Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.318305704157704,"antibodyCount":319,"monoclonalCount":138,"pubmedCount":null,"jensenScore":191.708658,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":46.60664892385803,"pubTatorScore":2.110427661295464,"self":"https://pharos.nih.gov/idg/api/v1/targets(12723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(12723)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(12723)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12723)/synonyms"},"_publications":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12723)/publications"},"_namespace":null},{"id":12724,"version":3,"created":1554956511000,"modified":1555040902000,"deprecated":false,"name":"Phosphatidylinositol 3-kinase regulatory subunit beta","accession":"O00459","gene":"PIK3R2","description":"Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8066571956556494,"antibodyCount":432,"monoclonalCount":48,"pubmedCount":null,"jensenScore":60.030554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":50.24589431186975,"pubTatorScore":2.481605850985268,"self":"https://pharos.nih.gov/idg/api/v1/targets(12724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(12724)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(12724)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(12724)/synonyms"},"_publications":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12724)/publications"},"_namespace":null},{"id":12725,"version":2,"created":1554956517000,"modified":1554956520000,"deprecated":false,"name":"Interferon-related developmental regulator 1","accession":"O00458","gene":"IFRD1","description":"Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.447153844763593,"antibodyCount":100,"monoclonalCount":2,"pubmedCount":null,"jensenScore":36.090683,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.93773054523847,"pubTatorScore":1.3622445277917978,"self":"https://pharos.nih.gov/idg/api/v1/targets(12725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(12725)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(12725)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12725)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12725)/publications"},"_namespace":null},{"id":12726,"version":3,"created":1554956521000,"modified":1555040904000,"deprecated":false,"name":"Methyltransferase-like protein 17, mitochondrial","accession":"Q9H7H0","gene":"METTL17","description":"May be a component of the mitochondrial small ribosomal subunit.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.23408320494763177,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.916667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.483950146368592,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(12726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12726)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(12726)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12726)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12726)/publications"},"_namespace":null},{"id":12727,"version":2,"created":1554956525000,"modified":1554956527000,"deprecated":false,"name":"Proline, histidine and glycine-rich protein 1","accession":"C9JFL3","gene":"PHGR1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.12493873660829995,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.86432926006799,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(12727)/properties"},"_links":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(12727)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12727)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12727)/publications"},"_namespace":null},{"id":12728,"version":2,"created":1554956527000,"modified":1554956528000,"deprecated":false,"name":"Developmental pluripotency-associated protein 2","accession":"Q7Z7J5","gene":"DPPA2","description":"Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4619370132174556,"antibodyCount":198,"monoclonalCount":114,"pubmedCount":null,"jensenScore":29.140531,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.687437012060116,"pubTatorScore":1.175849492418181,"self":"https://pharos.nih.gov/idg/api/v1/targets(12728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12728)/properties"},"_links":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(12728)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12728)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12728)/publications"},"_namespace":null},{"id":12729,"version":3,"created":1554956528000,"modified":1555040906000,"deprecated":false,"name":"GDNF family receptor alpha-2","accession":"O00451","gene":"GFRA2","description":"Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0865601196150472,"antibodyCount":252,"monoclonalCount":26,"pubmedCount":null,"jensenScore":8.454433,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.800609093277533,"pubTatorScore":1.4350564930102225,"self":"https://pharos.nih.gov/idg/api/v1/targets(12729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12729)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(12729)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12729)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12729)/publications"},"_namespace":null},{"id":12730,"version":2,"created":1554956531000,"modified":1554956535000,"deprecated":false,"name":"Leukocyte-specific transcript 1 protein","accession":"O00453","gene":"LST1","description":"Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":123,"monoclonalCount":33,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.066592441953375,"pubTatorScore":1.5729866169463316,"self":"https://pharos.nih.gov/idg/api/v1/targets(12730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(12730)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(12730)/links"},"_synonyms":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(12730)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12730)/publications"},"_namespace":null},{"id":12731,"version":3,"created":1554956535000,"modified":1555040907000,"deprecated":false,"name":"FAD-dependent oxidoreductase domain-containing protein 1","accession":"Q96CU9","gene":"FOXRED1","description":"Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8750612742490622,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.731075,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":34.40150446384026,"pubTatorScore":0.8303747404059146,"self":"https://pharos.nih.gov/idg/api/v1/targets(12731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(12731)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(12731)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12731)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12731)/publications"},"_namespace":null},{"id":12732,"version":3,"created":1554956540000,"modified":1555040908000,"deprecated":false,"name":"LHFPL tetraspan subfamily member 4 protein","accession":"Q7Z7J7","gene":"LHFPL4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.09691001300805639,"antibodyCount":22,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.80606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":18.27880273173293,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(12732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(12732)/properties"},"_links":{"count":615,"href":"https://pharos.nih.gov/idg/api/v1/targets(12732)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12732)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12732)/publications"},"_namespace":null},{"id":12733,"version":2,"created":1554956543000,"modified":1554956547000,"deprecated":false,"name":"Calcium/calmodulin-dependent protein kinase II inhibitor 1","accession":"Q7Z7J9","gene":"CAMK2N1","description":"Potent and specific inhibitor of CaM-kinase II (CAMK2).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5142338548432758,"antibodyCount":64,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.977733,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.229195031024275,"pubTatorScore":0.3403479248169838,"self":"https://pharos.nih.gov/idg/api/v1/targets(12733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(12733)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(12733)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12733)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12733)/publications"},"_namespace":null},{"id":12734,"version":2,"created":1554956547000,"modified":1554956549000,"deprecated":false,"name":"Sodium/hydrogen exchanger 9B1","accession":"Q4ZJI4","gene":"SLC9B1","description":"Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.013158426051459,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":101.669513,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.729492377695955,"pubTatorScore":1.1903316981702914,"self":"https://pharos.nih.gov/idg/api/v1/targets(12734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(12734)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(12734)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12734)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12734)/publications"},"_namespace":null},{"id":12735,"version":2,"created":1554956550000,"modified":1554956554000,"deprecated":false,"name":"DENN domain-containing protein 4C","accession":"Q5VZ89","gene":"DENND4C","description":"Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.4357285699957319,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.288462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.578749000911785,"pubTatorScore":-0.27300072919597457,"self":"https://pharos.nih.gov/idg/api/v1/targets(12735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(12735)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(12735)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12735)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12735)/publications"},"_namespace":null},{"id":12736,"version":2,"created":1554956555000,"modified":1554956559000,"deprecated":false,"name":"Type II iodothyronine deiodinase","accession":"Q92813","gene":"DIO2","description":"Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.6003626154339536,"antibodyCount":134,"monoclonalCount":0,"pubmedCount":null,"jensenScore":368.55663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.549424479260864,"pubTatorScore":2.286132388528864,"self":"https://pharos.nih.gov/idg/api/v1/targets(12736)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(12736)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(12736)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12736)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12736)/publications"},"_namespace":null},{"id":12737,"version":3,"created":1554956560000,"modified":1555040910000,"deprecated":false,"name":"T-cell leukemia/lymphoma protein 1A","accession":"P56279","gene":"TCL1A","description":"Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4245403440823825,"antibodyCount":269,"monoclonalCount":134,"pubmedCount":null,"jensenScore":29.311289,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":32.37463257146429,"pubTatorScore":2.1179612457036048,"self":"https://pharos.nih.gov/idg/api/v1/targets(12737)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(12737)/properties"},"_links":{"count":573,"href":"https://pharos.nih.gov/idg/api/v1/targets(12737)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12737)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12737)/publications"},"_namespace":null},{"id":12738,"version":2,"created":1554956563000,"modified":1554956565000,"deprecated":false,"name":"Protein p13 MTCP-1","accession":"P56278","gene":"MTCP1","description":"Enhances the phosphorylation and activation of AKT1 and AKT2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8750612742490622,"antibodyCount":51,"monoclonalCount":10,"pubmedCount":null,"jensenScore":7.682692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.899817474944985,"pubTatorScore":1.52484411662315,"self":"https://pharos.nih.gov/idg/api/v1/targets(12738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(12738)/properties"},"_links":{"count":777,"href":"https://pharos.nih.gov/idg/api/v1/targets(12738)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12738)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12738)/publications"},"_namespace":null},{"id":12739,"version":2,"created":1554956566000,"modified":1554956570000,"deprecated":false,"name":"Hyaluronan synthase 2","accession":"Q92819","gene":"HAS2","description":"Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4872795919128796,"antibodyCount":109,"monoclonalCount":33,"pubmedCount":null,"jensenScore":287.442023,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.72784490551589,"pubTatorScore":2.5164572718678175,"self":"https://pharos.nih.gov/idg/api/v1/targets(12739)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(12739)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(12739)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12739)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12739)/publications"},"_namespace":null},{"id":12740,"version":2,"created":1554956571000,"modified":1554956572000,"deprecated":false,"name":"Cx9C motif-containing protein 4","accession":"P56277","gene":"CMC4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.010723845848522,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.046429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.86043900733221,"pubTatorScore":1.3517310419061337,"self":"https://pharos.nih.gov/idg/api/v1/targets(12740)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(12740)/properties"},"_links":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(12740)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12740)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12740)/publications"},"_namespace":null},{"id":12741,"version":3,"created":1554956573000,"modified":1555040910000,"deprecated":false,"name":"Envoplakin","accession":"Q92817","gene":"EVPL","description":"Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4518895536183565,"antibodyCount":25,"monoclonalCount":5,"pubmedCount":null,"jensenScore":261.679716,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.283215571424396,"pubTatorScore":2.3053315010945954,"self":"https://pharos.nih.gov/idg/api/v1/targets(12741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(12741)/properties"},"_links":{"count":1009,"href":"https://pharos.nih.gov/idg/api/v1/targets(12741)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12741)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12741)/publications"},"_namespace":null},{"id":12742,"version":3,"created":1554956577000,"modified":1555040912000,"deprecated":false,"name":"Protein AKNAD1","accession":"Q5T1N1","gene":"AKNAD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.26626789030954945,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":19.773615792112306,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(12742)/properties"},"_links":{"count":659,"href":"https://pharos.nih.gov/idg/api/v1/targets(12742)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12742)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12742)/publications"},"_namespace":null},{"id":12743,"version":2,"created":1554956580000,"modified":1554956584000,"deprecated":false,"name":"Insulin-like growth factor-binding protein 7","accession":"Q16270","gene":"IGFBP7","description":"Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.548402362472855,"antibodyCount":373,"monoclonalCount":88,"pubmedCount":null,"jensenScore":379.966549,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.33106632020526,"pubTatorScore":2.7212503032935844,"self":"https://pharos.nih.gov/idg/api/v1/targets(12743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(12743)/properties"},"_links":{"count":1152,"href":"https://pharos.nih.gov/idg/api/v1/targets(12743)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12743)/synonyms"},"_publications":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12743)/publications"},"_namespace":null},{"id":12744,"version":2,"created":1554956585000,"modified":1554956588000,"deprecated":false,"name":"Renalase","accession":"Q5VYX0","gene":"RNLS","description":"Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.131394350124587,"antibodyCount":183,"monoclonalCount":26,"pubmedCount":null,"jensenScore":145.279866,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.115938468554216,"pubTatorScore":2.0633588152944866,"self":"https://pharos.nih.gov/idg/api/v1/targets(12744)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(12744)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(12744)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12744)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(12744)/publications"},"_namespace":null},{"id":12745,"version":3,"created":1554956589000,"modified":1555040914000,"deprecated":false,"name":"DNA polymerase epsilon subunit 2","accession":"P56282","gene":"POLE2","description":"Participates in DNA repair and in chromosomal DNA replication.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2146093680174552,"antibodyCount":91,"monoclonalCount":24,"pubmedCount":null,"jensenScore":16.803284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.33153588774934,"pubTatorScore":1.0922956842061358,"self":"https://pharos.nih.gov/idg/api/v1/targets(12745)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(12745)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(12745)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12745)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12745)/publications"},"_namespace":null},{"id":12746,"version":2,"created":1554956594000,"modified":1554956595000,"deprecated":false,"name":"Putative protein N-methyltransferase FAM86B2","accession":"P0C5J1","gene":"FAM86B2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.282520672370422,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(12746)/properties"},"_links":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(12746)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(12746)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12746)/publications"},"_namespace":null},{"id":12747,"version":2,"created":1554956596000,"modified":1554956597000,"deprecated":false,"name":"Protein HEATR9","accession":"A2RTY3","gene":"HEATR9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":68,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.648818549273946,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12747)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12747)/properties"},"_links":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12747)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12747)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12747)/publications"},"_namespace":null},{"id":12748,"version":2,"created":1554956597000,"modified":1554956600000,"deprecated":false,"name":"Splicing factor, arginine/serine-rich 19","accession":"Q9H7N4","gene":"SCAF1","description":"May function in pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4681538506793512,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.278822,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.745042775826235,"pubTatorScore":0.9558480201291164,"self":"https://pharos.nih.gov/idg/api/v1/targets(12748)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(12748)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(12748)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12748)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12748)/publications"},"_namespace":null},{"id":12749,"version":2,"created":1554956601000,"modified":1554956604000,"deprecated":false,"name":"Golgin subfamily A member 1","accession":"Q92805","gene":"GOLGA1","description":"Probably involved in maintaining Golgi structure.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2539443894763866,"antibodyCount":132,"monoclonalCount":28,"pubmedCount":null,"jensenScore":15.465864,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.17466281550848,"pubTatorScore":1.227630086693713,"self":"https://pharos.nih.gov/idg/api/v1/targets(12749)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(12749)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(12749)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12749)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12749)/publications"},"_namespace":null},{"id":12750,"version":3,"created":1554956605000,"modified":1555040915000,"deprecated":false,"name":"TATA-binding protein-associated factor 2N","accession":"Q92804","gene":"TAF15","description":"RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1687346288334635,"antibodyCount":197,"monoclonalCount":41,"pubmedCount":null,"jensenScore":15.195612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":43.94520379577478,"pubTatorScore":1.6833219353123734,"self":"https://pharos.nih.gov/idg/api/v1/targets(12750)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(12750)/properties"},"_links":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(12750)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12750)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12750)/publications"},"_namespace":null},{"id":12751,"version":2,"created":1554956608000,"modified":1554956612000,"deprecated":false,"name":"NEDD4-binding protein 2-like 2","accession":"Q92802","gene":"N4BP2L2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.01686792512184998,"antibodyCount":121,"monoclonalCount":34,"pubmedCount":null,"jensenScore":0.998655,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.15650823663523,"pubTatorScore":0.03236890923642764,"self":"https://pharos.nih.gov/idg/api/v1/targets(12751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(12751)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(12751)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12751)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12751)/publications"},"_namespace":null},{"id":12752,"version":2,"created":1554956613000,"modified":1554956616000,"deprecated":false,"name":"G protein-activated inward rectifier potassium channel 3","accession":"Q92806","gene":"KCNJ9","description":"This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.467069646408161,"antibodyCount":98,"monoclonalCount":0,"pubmedCount":null,"jensenScore":27.221012,"patentCount":1862,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.47762286498723,"pubTatorScore":1.212631423675082,"self":"https://pharos.nih.gov/idg/api/v1/targets(12752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(12752)/properties"},"_links":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(12752)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12752)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12752)/publications"},"_namespace":null},{"id":12753,"version":2,"created":1554956617000,"modified":1554956620000,"deprecated":false,"name":"Zinc finger CCCH domain-containing protein 13","accession":"Q5T200","gene":"ZC3H13","description":"Acts as component of the WTAP complex that is involved in RNA processing and cell cycle (PubMed:24100041).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5422917801202658,"antibodyCount":84,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.605358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.62075335744964,"pubTatorScore":0.004116648137179551,"self":"https://pharos.nih.gov/idg/api/v1/targets(12753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(12753)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(12753)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12753)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12753)/publications"},"_namespace":null},{"id":12754,"version":3,"created":1554956621000,"modified":1555040916000,"deprecated":false,"name":"Cyclic nucleotide-gated olfactory channel","accession":"Q16280","gene":"CNGA2","description":"Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.7978005821145338,"antibodyCount":204,"monoclonalCount":0,"pubmedCount":null,"jensenScore":61.204422,"patentCount":1725,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":19.257295814884007,"pubTatorScore":1.3966558662635018,"self":"https://pharos.nih.gov/idg/api/v1/targets(12754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12754)/properties"},"_links":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(12754)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12754)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12754)/publications"},"_namespace":null},{"id":12755,"version":3,"created":1554956623000,"modified":1555040916000,"deprecated":false,"name":"Cyclic nucleotide-gated cation channel alpha-3","accession":"Q16281","gene":"CNGA3","description":"Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.9561365092669194,"antibodyCount":67,"monoclonalCount":4,"pubmedCount":null,"jensenScore":94.779748,"patentCount":2064,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":29.961779910387524,"pubTatorScore":1.8763795793900524,"self":"https://pharos.nih.gov/idg/api/v1/targets(12755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(12755)/properties"},"_links":{"count":718,"href":"https://pharos.nih.gov/idg/api/v1/targets(12755)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12755)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12755)/publications"},"_namespace":null},{"id":12756,"version":3,"created":1554956627000,"modified":1555040918000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 22","accession":"Q5VYY1","gene":"ANKRD22","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.20677374744975427,"antibodyCount":91,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.469935,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":19.369600616846697,"pubTatorScore":-0.2828048186035601,"self":"https://pharos.nih.gov/idg/api/v1/targets(12756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(12756)/properties"},"_links":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(12756)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12756)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12756)/publications"},"_namespace":null},{"id":12757,"version":3,"created":1554956631000,"modified":1555040919000,"deprecated":false,"name":"60S ribosomal protein L36a","accession":"P83881","gene":"RPL36A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9422979218726304,"antibodyCount":114,"monoclonalCount":46,"pubmedCount":null,"jensenScore":7.44505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.418274376096246,"pubTatorScore":0.7861201721586556,"self":"https://pharos.nih.gov/idg/api/v1/targets(12757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(12757)/properties"},"_links":{"count":978,"href":"https://pharos.nih.gov/idg/api/v1/targets(12757)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12757)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12757)/publications"},"_namespace":null},{"id":12758,"version":2,"created":1554956635000,"modified":1554956637000,"deprecated":false,"name":"Cilia- and flagella-associated protein 69","accession":"A5D8W1","gene":"CFAP69","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3143939615649075,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.268864900717702,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(12758)/properties"},"_links":{"count":748,"href":"https://pharos.nih.gov/idg/api/v1/targets(12758)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12758)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12758)/publications"},"_namespace":null},{"id":12759,"version":3,"created":1554956638000,"modified":1555040922000,"deprecated":false,"name":"NT-3 growth factor receptor","accession":"Q16288","gene":"NTRK3","description":"Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.6204334400271345,"antibodyCount":559,"monoclonalCount":168,"pubmedCount":null,"jensenScore":371.684095,"patentCount":38124,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":50.689231984015635,"pubTatorScore":2.3622069628699887,"self":"https://pharos.nih.gov/idg/api/v1/targets(12759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(12759)/properties"},"_links":{"count":1094,"href":"https://pharos.nih.gov/idg/api/v1/targets(12759)/links"},"_synonyms":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(12759)/synonyms"},"_publications":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12759)/publications"},"_namespace":null},{"id":12760,"version":2,"created":1554956647000,"modified":1554956648000,"deprecated":false,"name":"Cancer/testis antigen 62","accession":"P0C5K7","gene":"CT62","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.041392684723930574,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.058824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.584528533055591,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(12760)/properties"},"_links":{"count":551,"href":"https://pharos.nih.gov/idg/api/v1/targets(12760)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12760)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12760)/publications"},"_namespace":null},{"id":12761,"version":2,"created":1554956648000,"modified":1554956648000,"deprecated":false,"name":"Putative tumor antigen NA88-A","accession":"P0C5K6","gene":"VENTXP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.154307186797575,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12761)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12761)/links"},"_synonyms":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12761)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12761)/publications"},"_namespace":null},{"id":12762,"version":3,"created":1554956648000,"modified":1555040924000,"deprecated":false,"name":"Zinc finger protein 563","accession":"Q8TA94","gene":"ZNF563","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":90,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":25.960838705354245,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(12762)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(12762)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12762)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12762)/publications"},"_namespace":null},{"id":12763,"version":2,"created":1554956651000,"modified":1554956654000,"deprecated":false,"name":"Zinc finger SWIM domain-containing protein 4","accession":"Q9H7M6","gene":"ZSWIM4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4164234140041387,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.648352,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.12141435670221,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12763)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(12763)/properties"},"_links":{"count":765,"href":"https://pharos.nih.gov/idg/api/v1/targets(12763)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12763)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12763)/publications"},"_namespace":null},{"id":12764,"version":2,"created":1554956654000,"modified":1554956659000,"deprecated":false,"name":"Histone-lysine N-methyltransferase EZH1","accession":"Q92800","gene":"EZH1","description":"Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.2607164110065887,"antibodyCount":291,"monoclonalCount":7,"pubmedCount":null,"jensenScore":14.812982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.67067191656334,"pubTatorScore":1.3107646836791764,"self":"https://pharos.nih.gov/idg/api/v1/targets(12764)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(12764)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(12764)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(12764)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12764)/publications"},"_namespace":null},{"id":12765,"version":2,"created":1554956660000,"modified":1554956663000,"deprecated":false,"name":"V-type immunoglobulin domain-containing suppressor of T-cell activation","accession":"Q9H7M9","gene":"VSIR","description":"Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.889423756405101,"antibodyCount":156,"monoclonalCount":92,"pubmedCount":null,"jensenScore":747.85346,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.94871337602967,"self":"https://pharos.nih.gov/idg/api/v1/targets(12765)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(12765)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(12765)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12765)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12765)/publications"},"_namespace":null},{"id":12766,"version":2,"created":1554956664000,"modified":1554956667000,"deprecated":false,"name":"Janus kinase and microtubule-interacting protein 3","accession":"Q5VZ66","gene":"JAKMIP3","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.27300127206373764,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.633987,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.712724130618387,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12766)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(12766)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(12766)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12766)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12766)/publications"},"_namespace":null},{"id":12767,"version":3,"created":1554956668000,"modified":1554956829000,"deprecated":false,"name":"cGMP-dependent 3',5'-cyclic phosphodiesterase","accession":"O00408","gene":"PDE2A","description":"Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.8347164911777705,"antibodyCount":190,"monoclonalCount":79,"pubmedCount":null,"jensenScore":64.63982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.02164112887952,"pubTatorScore":1.6164485731413358,"self":"https://pharos.nih.gov/idg/api/v1/targets(12767)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(12767)/properties"},"_links":{"count":1566,"href":"https://pharos.nih.gov/idg/api/v1/targets(12767)/links"},"_synonyms":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(12767)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12767)/publications"},"_namespace":null},{"id":12768,"version":2,"created":1554956831000,"modified":1554956835000,"deprecated":false,"name":"Retinitis pigmentosa 9 protein","accession":"Q8TA86","gene":"RP9","description":"Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7369012741478498,"antibodyCount":39,"monoclonalCount":3,"pubmedCount":null,"jensenScore":53.259731,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.432143896221472,"pubTatorScore":1.307530737297884,"self":"https://pharos.nih.gov/idg/api/v1/targets(12768)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(12768)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(12768)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12768)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12768)/publications"},"_namespace":null},{"id":12769,"version":3,"created":1554956836000,"modified":1555040925000,"deprecated":false,"name":"Forkhead box protein N3","accession":"O00409","gene":"FOXN3","description":"Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3322628406825385,"antibodyCount":113,"monoclonalCount":12,"pubmedCount":null,"jensenScore":20.368207,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":39.3952826934903,"pubTatorScore":1.230023871254607,"self":"https://pharos.nih.gov/idg/api/v1/targets(12769)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12769)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(12769)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12769)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12769)/publications"},"_namespace":null},{"id":12770,"version":2,"created":1554956841000,"modified":1554956844000,"deprecated":false,"name":"Intracellular hyaluronan-binding protein 4","accession":"Q5JVS0","gene":"HABP4","description":"RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9785391656567765,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.054337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.85433105598146,"pubTatorScore":1.0314083834526433,"self":"https://pharos.nih.gov/idg/api/v1/targets(12770)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(12770)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(12770)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12770)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12770)/publications"},"_namespace":null},{"id":12771,"version":4,"created":1554956845000,"modified":1555040926000,"deprecated":false,"name":"Acetyl-coenzyme A transporter 1","accession":"O00400","gene":"SLC33A1","description":"Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.1776926286277054,"antibodyCount":114,"monoclonalCount":24,"pubmedCount":null,"jensenScore":16.143483,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.645538362889184,"pubTatorScore":1.091344792069887,"self":"https://pharos.nih.gov/idg/api/v1/targets(12771)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(12771)/properties"},"_links":{"count":1169,"href":"https://pharos.nih.gov/idg/api/v1/targets(12771)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12771)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12771)/publications"},"_namespace":null},{"id":12772,"version":3,"created":1554956900000,"modified":1555040928000,"deprecated":false,"name":"Neural Wiskott-Aldrich syndrome protein","accession":"O00401","gene":"WASL","description":"Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.401792955419108,"antibodyCount":154,"monoclonalCount":25,"pubmedCount":null,"jensenScore":254.702693,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":47.651609157818875,"pubTatorScore":2.2557721291552184,"self":"https://pharos.nih.gov/idg/api/v1/targets(12772)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(12772)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(12772)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12772)/synonyms"},"_publications":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12772)/publications"},"_namespace":null},{"id":12773,"version":3,"created":1554956906000,"modified":1555040930000,"deprecated":false,"name":"HCLS1-binding protein 3","accession":"Q53T59","gene":"HS1BP3","description":"May be a modulator of IL-2 signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2322698345590766,"antibodyCount":95,"monoclonalCount":22,"pubmedCount":null,"jensenScore":18.150504,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":32.61892668296949,"pubTatorScore":0.9120447941922578,"self":"https://pharos.nih.gov/idg/api/v1/targets(12773)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(12773)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(12773)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12773)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12773)/publications"},"_namespace":null},{"id":12774,"version":3,"created":1554956910000,"modified":1555040931000,"deprecated":false,"name":"Sin3 histone deacetylase corepressor complex component SDS3","accession":"Q9H7L9","gene":"SUDS3","description":"Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6112508611558092,"antibodyCount":89,"monoclonalCount":4,"pubmedCount":null,"jensenScore":36.87236,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.66398579101579,"pubTatorScore":1.1697034644111268,"self":"https://pharos.nih.gov/idg/api/v1/targets(12774)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(12774)/properties"},"_links":{"count":1133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12774)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12774)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12774)/publications"},"_namespace":null},{"id":12775,"version":3,"created":1554956914000,"modified":1555040932000,"deprecated":false,"name":"Coiled-coil domain-containing protein 151","accession":"A5D8V7","gene":"CCDC151","description":"Ciliary protein involved in outer dynein arm assembly and required for motile cilia function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3832167554704519,"antibodyCount":71,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.192308,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":24.65808523879803,"pubTatorScore":0.4445651687526213,"self":"https://pharos.nih.gov/idg/api/v1/targets(12775)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12775)/properties"},"_links":{"count":832,"href":"https://pharos.nih.gov/idg/api/v1/targets(12775)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12775)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12775)/publications"},"_namespace":null},{"id":12776,"version":3,"created":1554956918000,"modified":1555040934000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 37C","accession":"A5D8V6","gene":"VPS37C","description":"Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.35561569581101854,"antibodyCount":128,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.291906,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":37.82143174811998,"pubTatorScore":0.24851812349688332,"self":"https://pharos.nih.gov/idg/api/v1/targets(12776)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(12776)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(12776)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12776)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12776)/publications"},"_namespace":null},{"id":12777,"version":2,"created":1554956922000,"modified":1554956925000,"deprecated":false,"name":"Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1","accession":"Q9H7L2","gene":"KIR3DX1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.19279695524094098,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.033333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.556868425587535,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12777)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(12777)/properties"},"_links":{"count":649,"href":"https://pharos.nih.gov/idg/api/v1/targets(12777)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12777)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12777)/publications"},"_namespace":null},{"id":12778,"version":2,"created":1554956925000,"modified":1554956929000,"deprecated":false,"name":"Probable threonine--tRNA ligase 2, cytoplasmic","accession":"A2RTX5","gene":"TARSL2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4948827307149775,"antibodyCount":125,"monoclonalCount":0,"pubmedCount":null,"jensenScore":25.261599,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.48966518441491,"pubTatorScore":0.669006811979609,"self":"https://pharos.nih.gov/idg/api/v1/targets(12778)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(12778)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(12778)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12778)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12778)/publications"},"_namespace":null},{"id":12779,"version":2,"created":1554956930000,"modified":1554956933000,"deprecated":false,"name":"Protein SLX4IP","accession":"Q5VYV7","gene":"SLX4IP","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4423591485810879,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.595455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.01858087572663,"pubTatorScore":0.12739930571226205,"self":"https://pharos.nih.gov/idg/api/v1/targets(12779)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(12779)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(12779)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12779)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12779)/publications"},"_namespace":null},{"id":12780,"version":2,"created":1554956934000,"modified":1554956937000,"deprecated":false,"name":"FK506-binding protein 15","accession":"Q5T1M5","gene":"FKBP15","description":"May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4393326981732075,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.188816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.639038673066324,"pubTatorScore":0.8885004049066579,"self":"https://pharos.nih.gov/idg/api/v1/targets(12780)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(12780)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(12780)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12780)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12780)/publications"},"_namespace":null},{"id":12781,"version":2,"created":1554956938000,"modified":1554956938000,"deprecated":false,"name":"Sulfotransferase 1C3","accession":"Q6IMI6","gene":"SULT1C3","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.541195081702771,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.413098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.775580410560268,"pubTatorScore":0.7249581590164857,"self":"https://pharos.nih.gov/idg/api/v1/targets(12781)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12781)/properties"},"_links":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(12781)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12781)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12781)/publications"},"_namespace":null},{"id":12782,"version":2,"created":1554956938000,"modified":1554956942000,"deprecated":false,"name":"Eukaryotic elongation factor 2 kinase","accession":"O00418","gene":"EEF2K","description":"Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.3355865121555492,"antibodyCount":319,"monoclonalCount":10,"pubmedCount":null,"jensenScore":25.139443,"patentCount":4179,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.36540350428061,"pubTatorScore":1.939012020049876,"self":"https://pharos.nih.gov/idg/api/v1/targets(12782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(12782)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(12782)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12782)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12782)/publications"},"_namespace":null},{"id":12783,"version":2,"created":1554956943000,"modified":1554956944000,"deprecated":false,"name":"Sulfotransferase 6B1","accession":"Q6IMI4","gene":"SULT6B1","description":"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.19781050975113554,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.722223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.288957632847314,"pubTatorScore":0.48902043106861287,"self":"https://pharos.nih.gov/idg/api/v1/targets(12783)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(12783)/properties"},"_links":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12783)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12783)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12783)/publications"},"_namespace":null},{"id":12784,"version":2,"created":1554956944000,"modified":1554956946000,"deprecated":false,"name":"Transmembrane protein 179B","accession":"Q7Z7N9","gene":"TMEM179B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":10,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.206442890242485,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(12784)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(12784)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12784)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12784)/publications"},"_namespace":null},{"id":12785,"version":2,"created":1554956946000,"modified":1554956947000,"deprecated":false,"name":"Izumo sperm-egg fusion protein 3","accession":"Q5VZ72","gene":"IZUMO3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.047923551376211425,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.003205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.328771041941041,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12785)/properties"},"_links":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12785)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(12785)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12785)/publications"},"_namespace":null},{"id":12786,"version":2,"created":1554956947000,"modified":1554956948000,"deprecated":false,"name":"Forkhead box protein B2","accession":"Q5VYV0","gene":"FOXB2","description":"Transcription factor.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.0,"antibodyCount":133,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.183116712483644,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12786)/properties"},"_links":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12786)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12786)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12786)/publications"},"_namespace":null},{"id":12787,"version":2,"created":1554956948000,"modified":1554956948000,"deprecated":false,"name":"Testis-expressed protein 50","accession":"A0A1B0GTY4","gene":"TEX50","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12787)/properties"},"_links":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12787)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12787)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12787)/publications"},"_namespace":null},{"id":12788,"version":2,"created":1554956948000,"modified":1554956952000,"deprecated":false,"name":"DNA-directed RNA polymerase, mitochondrial","accession":"O00411","gene":"POLRMT","description":"DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7597696009493178,"antibodyCount":71,"monoclonalCount":14,"pubmedCount":null,"jensenScore":55.171368,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.76496925822307,"pubTatorScore":1.5295736196789191,"self":"https://pharos.nih.gov/idg/api/v1/targets(12788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(12788)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(12788)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12788)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12788)/publications"},"_namespace":null},{"id":12789,"version":2,"created":1554956953000,"modified":1554956957000,"deprecated":false,"name":"Importin-5","accession":"O00410","gene":"IPO5","description":"Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.180522529760034,"antibodyCount":122,"monoclonalCount":39,"pubmedCount":null,"jensenScore":149.520672,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.25499896599655,"pubTatorScore":1.6714138694471743,"self":"https://pharos.nih.gov/idg/api/v1/targets(12789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(12789)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(12789)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12789)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12789)/publications"},"_namespace":null},{"id":12790,"version":2,"created":1554956958000,"modified":1554956961000,"deprecated":false,"name":"Aspartate beta-hydroxylase domain-containing protein 1","accession":"Q5U4P2","gene":"ASPHD1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.93154458731615,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12790)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(12790)/properties"},"_links":{"count":801,"href":"https://pharos.nih.gov/idg/api/v1/targets(12790)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12790)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12790)/publications"},"_namespace":null},{"id":12791,"version":3,"created":1554956962000,"modified":1555040935000,"deprecated":false,"name":"Orexigenic neuropeptide QRFP","accession":"P83859","gene":"QRFP","description":"Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5915927956586167,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":54.92988,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":14.666891964454058,"pubTatorScore":1.422425659951753,"self":"https://pharos.nih.gov/idg/api/v1/targets(12791)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(12791)/properties"},"_links":{"count":707,"href":"https://pharos.nih.gov/idg/api/v1/targets(12791)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12791)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12791)/publications"},"_namespace":null},{"id":12792,"version":2,"created":1554956964000,"modified":1554956965000,"deprecated":false,"name":"Putative chondrosarcoma-associated gene 1 protein","accession":"Q6PB30","gene":"CSAG1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3187587626244128,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.027777,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.621442098687607,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12792)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12792)/properties"},"_links":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(12792)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(12792)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12792)/publications"},"_namespace":null},{"id":12793,"version":2,"created":1554956965000,"modified":1554956969000,"deprecated":false,"name":"Ras-related GTP-binding protein B","accession":"Q5VZM2","gene":"RRAGB","description":"Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4072909750363845,"antibodyCount":113,"monoclonalCount":7,"pubmedCount":null,"jensenScore":26.22744,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.070255603756525,"pubTatorScore":0.9138354606447615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12793)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(12793)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(12793)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(12793)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12793)/publications"},"_namespace":null},{"id":12794,"version":2,"created":1554956970000,"modified":1554956973000,"deprecated":false,"name":"RNA binding motif protein, X-linked-like-1","accession":"Q96E39","gene":"RBMXL1","description":"RNA-binding protein which may be involved in pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.0071785834690047765,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.738096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.94141131155991,"pubTatorScore":1.0469965181331975,"self":"https://pharos.nih.gov/idg/api/v1/targets(12794)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(12794)/properties"},"_links":{"count":1004,"href":"https://pharos.nih.gov/idg/api/v1/targets(12794)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12794)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12794)/publications"},"_namespace":null},{"id":12795,"version":3,"created":1554956973000,"modified":1555040935000,"deprecated":false,"name":"Mucin-like protein 1","accession":"Q96DR8","gene":"MUCL1","description":"May play a role as marker for the diagnosis of metastatic breast cancer.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6846584728309686,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":45.661311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":14.091825042685269,"pubTatorScore":1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12795)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(12795)/properties"},"_links":{"count":664,"href":"https://pharos.nih.gov/idg/api/v1/targets(12795)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12795)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12795)/publications"},"_namespace":null},{"id":12796,"version":3,"created":1554956976000,"modified":1555040937000,"deprecated":false,"name":"Zinc finger MYND domain-containing protein 19","accession":"Q96E35","gene":"ZMYND19","description":"May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3979400086720376,"antibodyCount":50,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.998611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.97196212843322,"pubTatorScore":0.25123244612501977,"self":"https://pharos.nih.gov/idg/api/v1/targets(12796)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12796)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(12796)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12796)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12796)/publications"},"_namespace":null},{"id":12797,"version":2,"created":1554956980000,"modified":1554956980000,"deprecated":false,"name":"BPI fold-containing family A member 2","accession":"Q96DR5","gene":"BPIFA2","description":"Has strong antibacterial activity against P. aeruginosa.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7322300616584565,"antibodyCount":133,"monoclonalCount":115,"pubmedCount":null,"jensenScore":50.484031,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.193694302826891,"pubTatorScore":1.8257763139121752,"self":"https://pharos.nih.gov/idg/api/v1/targets(12797)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(12797)/properties"},"_links":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12797)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12797)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12797)/publications"},"_namespace":null},{"id":12798,"version":2,"created":1554956981000,"modified":1554956983000,"deprecated":false,"name":"Uncharacterized protein CXorf38","accession":"Q8TB03","gene":"CXorf38","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12798)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(12798)/properties"},"_links":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(12798)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12798)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12798)/publications"},"_namespace":null},{"id":12799,"version":2,"created":1554956984000,"modified":1554956987000,"deprecated":false,"name":"StAR-related lipid transfer protein 4","accession":"Q96DR4","gene":"STARD4","description":"May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1458552541406075,"antibodyCount":83,"monoclonalCount":6,"pubmedCount":null,"jensenScore":14.818097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.31748621976801,"pubTatorScore":1.123760919456763,"self":"https://pharos.nih.gov/idg/api/v1/targets(12799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(12799)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(12799)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12799)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12799)/publications"},"_namespace":null},{"id":12800,"version":2,"created":1554956988000,"modified":1554956989000,"deprecated":false,"name":"UBA-like domain-containing protein 1","accession":"Q8TB05","gene":"UBALD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":6,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.834202921863284,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(12800)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(12800)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12800)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12800)/publications"},"_namespace":null},{"id":12801,"version":3,"created":1554956990000,"modified":1555040938000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 26","accession":"Q96DR7","gene":"ARHGEF26","description":"Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8708357029601147,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.214215,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.633096781923214,"pubTatorScore":0.9462416499074068,"self":"https://pharos.nih.gov/idg/api/v1/targets(12801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(12801)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(12801)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12801)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12801)/publications"},"_namespace":null},{"id":12802,"version":2,"created":1554956995000,"modified":1554956997000,"deprecated":false,"name":"Dual specificity protein phosphatase 13 isoform A","accession":"Q6B8I1","gene":"DUSP13","description":"Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.263297846053061,"antibodyCount":180,"monoclonalCount":2,"pubmedCount":null,"jensenScore":34.377118,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.873210778305623,"pubTatorScore":1.0360963187044425,"self":"https://pharos.nih.gov/idg/api/v1/targets(12802)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(12802)/properties"},"_links":{"count":677,"href":"https://pharos.nih.gov/idg/api/v1/targets(12802)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12802)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12802)/publications"},"_namespace":null},{"id":12803,"version":3,"created":1554956997000,"modified":1555040940000,"deprecated":false,"name":"Trem-like transcript 2 protein","accession":"Q5T2D2","gene":"TREML2","description":"Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9979443192454118,"antibodyCount":126,"monoclonalCount":41,"pubmedCount":null,"jensenScore":8.486239,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":24.66413652833792,"pubTatorScore":0.8669433076156315,"self":"https://pharos.nih.gov/idg/api/v1/targets(12803)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(12803)/properties"},"_links":{"count":725,"href":"https://pharos.nih.gov/idg/api/v1/targets(12803)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12803)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12803)/publications"},"_namespace":null},{"id":12804,"version":3,"created":1554956999000,"modified":1555040940000,"deprecated":false,"name":"B-cell receptor CD22","accession":"P20273","gene":"CD22","description":"Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.919748813282009,"antibodyCount":1494,"monoclonalCount":1025,"pubmedCount":null,"jensenScore":829.04263,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.207070060612146,"pubTatorScore":2.7328343740864534,"self":"https://pharos.nih.gov/idg/api/v1/targets(12804)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(12804)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(12804)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(12804)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(12804)/publications"},"_namespace":null},{"id":12805,"version":3,"created":1554957007000,"modified":1555040942000,"deprecated":false,"name":"OTU domain-containing protein 3","accession":"Q5T2D3","gene":"OTUD3","description":"Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4121804524915048,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.36505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":28.75131825740915,"pubTatorScore":0.3832166320459405,"self":"https://pharos.nih.gov/idg/api/v1/targets(12805)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(12805)/properties"},"_links":{"count":889,"href":"https://pharos.nih.gov/idg/api/v1/targets(12805)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12805)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12805)/publications"},"_namespace":null},{"id":12806,"version":2,"created":1554957011000,"modified":1554957014000,"deprecated":false,"name":"Protein inscuteable homolog","accession":"Q1MX18","gene":"INSC","description":"May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8866139042116024,"antibodyCount":165,"monoclonalCount":1,"pubmedCount":null,"jensenScore":62.260423,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.71581545770945,"pubTatorScore":1.6118412629336007,"self":"https://pharos.nih.gov/idg/api/v1/targets(12806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(12806)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(12806)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12806)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12806)/publications"},"_namespace":null},{"id":12807,"version":2,"created":1554957014000,"modified":1554957017000,"deprecated":false,"name":"Hephaestin-like protein 1","accession":"Q6MZM0","gene":"HEPHL1","description":"May function as a ferroxidase and may be involved in copper transport and homeostasis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.1898795444460947,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.535714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.379085918840975,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(12807)/properties"},"_links":{"count":648,"href":"https://pharos.nih.gov/idg/api/v1/targets(12807)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12807)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12807)/publications"},"_namespace":null},{"id":12808,"version":3,"created":1554957017000,"modified":1555040943000,"deprecated":false,"name":"Transcription factor BTF3","accession":"P20290","gene":"BTF3","description":"When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.020607799082805,"antibodyCount":172,"monoclonalCount":18,"pubmedCount":null,"jensenScore":106.593232,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":33.88012443965563,"pubTatorScore":1.6177327367723549,"self":"https://pharos.nih.gov/idg/api/v1/targets(12808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(12808)/properties"},"_links":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(12808)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12808)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12808)/publications"},"_namespace":null},{"id":12809,"version":3,"created":1554957021000,"modified":1555040945000,"deprecated":false,"name":"Dehydrodolichyl diphosphate synthase complex subunit NUS1","accession":"Q96E22","gene":"NUS1","description":"With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3756854106621614,"antibodyCount":55,"monoclonalCount":12,"pubmedCount":null,"jensenScore":28.505609,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":29.707318292412555,"pubTatorScore":1.1230734591147753,"self":"https://pharos.nih.gov/idg/api/v1/targets(12809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(12809)/properties"},"_links":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(12809)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12809)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12809)/publications"},"_namespace":null},{"id":12810,"version":4,"created":1554957025000,"modified":1555040946000,"deprecated":false,"name":"Arachidonate 5-lipoxygenase-activating protein","accession":"P20292","gene":"ALOX5AP","description":"Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.6813399202926793,"antibodyCount":174,"monoclonalCount":8,"pubmedCount":null,"jensenScore":446.804896,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.08572022794089,"pubTatorScore":3.1585389269887245,"self":"https://pharos.nih.gov/idg/api/v1/targets(12810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":418,"href":"https://pharos.nih.gov/idg/api/v1/targets(12810)/properties"},"_links":{"count":2941,"href":"https://pharos.nih.gov/idg/api/v1/targets(12810)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12810)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12810)/publications"},"_namespace":null},{"id":12811,"version":2,"created":1554957686000,"modified":1554957686000,"deprecated":false,"name":"Proline-rich protein 27","accession":"Q6MZM9","gene":"PRR27","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5351132018783052,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.291667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.933208866981175,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12811)/properties"},"_links":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(12811)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(12811)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12811)/publications"},"_namespace":null},{"id":12812,"version":2,"created":1554957687000,"modified":1554957690000,"deprecated":false,"name":"Transcription termination factor 3, mitochondrial","accession":"Q96E29","gene":"MTERF3","description":"Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.1142614244306217,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.224113,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.557594067146113,"pubTatorScore":0.7603865923267564,"self":"https://pharos.nih.gov/idg/api/v1/targets(12812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(12812)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(12812)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12812)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12812)/publications"},"_namespace":null},{"id":12813,"version":2,"created":1554957690000,"modified":1554957693000,"deprecated":false,"name":"UPF0668 protein C10orf76","accession":"Q5T2E6","gene":"C10orf76","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(12813)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(12813)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12813)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12813)/publications"},"_namespace":null},{"id":12814,"version":3,"created":1554957694000,"modified":1555040952000,"deprecated":false,"name":"Colipase-like protein 1","accession":"A2RUU4","gene":"CLPSL1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.0,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":7.30263123640043,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(12814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12814)/properties"},"_links":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12814)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12814)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12814)/publications"},"_namespace":null},{"id":12815,"version":3,"created":1554957695000,"modified":1555040953000,"deprecated":false,"name":"G-protein coupled receptor 183","accession":"P32249","gene":"GPR183","description":"G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.6120637337052683,"antibodyCount":143,"monoclonalCount":12,"pubmedCount":null,"jensenScore":45.72017,"patentCount":5011,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":29,"knowledgeAvailability":30.964170723134718,"pubTatorScore":1.3609669468137389,"self":"https://pharos.nih.gov/idg/api/v1/targets(12815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(12815)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(12815)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12815)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12815)/publications"},"_namespace":null},{"id":12816,"version":3,"created":1554957702000,"modified":1555040954000,"deprecated":false,"name":"Ribosome-recycling factor, mitochondrial","accession":"Q96E11","gene":"MRRF","description":"Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.310510000591546,"antibodyCount":165,"monoclonalCount":74,"pubmedCount":null,"jensenScore":196.586434,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":34.10974358537968,"pubTatorScore":1.9392695763492087,"self":"https://pharos.nih.gov/idg/api/v1/targets(12816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(12816)/properties"},"_links":{"count":1062,"href":"https://pharos.nih.gov/idg/api/v1/targets(12816)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12816)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12816)/publications"},"_namespace":null},{"id":12817,"version":2,"created":1554957706000,"modified":1554957709000,"deprecated":false,"name":"Ras-related protein Rab-3C","accession":"Q96E17","gene":"RAB3C","description":"Protein transport. Probably involved in vesicular traffic (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.05904625330165,"antibodyCount":90,"monoclonalCount":5,"pubmedCount":null,"jensenScore":11.196156,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.02513114071936,"pubTatorScore":0.8187075085382783,"self":"https://pharos.nih.gov/idg/api/v1/targets(12817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12817)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(12817)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12817)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12817)/publications"},"_namespace":null},{"id":12818,"version":2,"created":1554957710000,"modified":1554957712000,"deprecated":false,"name":"Homeobox protein OTX1","accession":"P32242","gene":"OTX1","description":"Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8395398727255703,"antibodyCount":214,"monoclonalCount":62,"pubmedCount":null,"jensenScore":67.837657,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.09359245946047,"pubTatorScore":1.4423865660532684,"self":"https://pharos.nih.gov/idg/api/v1/targets(12818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(12818)/properties"},"_links":{"count":690,"href":"https://pharos.nih.gov/idg/api/v1/targets(12818)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12818)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12818)/publications"},"_namespace":null},{"id":12819,"version":2,"created":1554957713000,"modified":1554957716000,"deprecated":false,"name":"Small integral membrane protein 19","accession":"Q96E16","gene":"SMIM19","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.404388837635032,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(12819)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(12819)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12819)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12819)/publications"},"_namespace":null},{"id":12820,"version":2,"created":1554957716000,"modified":1554957719000,"deprecated":false,"name":"Ermin","accession":"Q8TAM6","gene":"ERMN","description":"Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0156391455988318,"antibodyCount":81,"monoclonalCount":4,"pubmedCount":null,"jensenScore":10.962027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.294100760168252,"pubTatorScore":0.9554471624564206,"self":"https://pharos.nih.gov/idg/api/v1/targets(12820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(12820)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(12820)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12820)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12820)/publications"},"_namespace":null},{"id":12821,"version":3,"created":1554957720000,"modified":1555040955000,"deprecated":false,"name":"Vasoactive intestinal polypeptide receptor 1","accession":"P32241","gene":"VIPR1","description":"This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.6420937259448443,"antibodyCount":324,"monoclonalCount":29,"pubmedCount":null,"jensenScore":410.640286,"patentCount":38157,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":31.32464564728895,"pubTatorScore":2.4998708107870744,"self":"https://pharos.nih.gov/idg/api/v1/targets(12821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(12821)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(12821)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(12821)/synonyms"},"_publications":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12821)/publications"},"_namespace":null},{"id":12822,"version":2,"created":1554957726000,"modified":1554957729000,"deprecated":false,"name":"Homeobox protein OTX2","accession":"P32243","gene":"OTX2","description":"Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4848642893819743,"antibodyCount":248,"monoclonalCount":72,"pubmedCount":null,"jensenScore":316.956019,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.85725645900884,"pubTatorScore":2.116882033184873,"self":"https://pharos.nih.gov/idg/api/v1/targets(12822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(12822)/properties"},"_links":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(12822)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12822)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12822)/publications"},"_namespace":null},{"id":12823,"version":3,"created":1554957730000,"modified":1555040957000,"deprecated":false,"name":"Bardet-Biedl syndrome 10 protein","accession":"Q8TAM1","gene":"BBS10","description":"Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.248523891135363,"antibodyCount":116,"monoclonalCount":2,"pubmedCount":null,"jensenScore":17.649547,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.51070828784312,"pubTatorScore":1.2521456712929266,"self":"https://pharos.nih.gov/idg/api/v1/targets(12823)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12823)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(12823)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12823)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12823)/publications"},"_namespace":null},{"id":12824,"version":4,"created":1554957734000,"modified":1555040958000,"deprecated":false,"name":"C-C chemokine receptor type 1","accession":"P32246","gene":"CCR1","description":"Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.532862696857111,"antibodyCount":306,"monoclonalCount":105,"pubmedCount":null,"jensenScore":321.890201,"patentCount":46869,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":36.7585670991717,"pubTatorScore":2.429937419503807,"self":"https://pharos.nih.gov/idg/api/v1/targets(12824)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(12824)/properties"},"_links":{"count":1227,"href":"https://pharos.nih.gov/idg/api/v1/targets(12824)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12824)/synonyms"},"_publications":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12824)/publications"},"_namespace":null},{"id":12825,"version":2,"created":1554957840000,"modified":1554957844000,"deprecated":false,"name":"Tetratricopeptide repeat protein 8","accession":"Q8TAM2","gene":"TTC8","description":"The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6000519118536614,"antibodyCount":177,"monoclonalCount":26,"pubmedCount":null,"jensenScore":3.719212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.38784054490931,"pubTatorScore":1.0542449738326236,"self":"https://pharos.nih.gov/idg/api/v1/targets(12825)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(12825)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(12825)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(12825)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12825)/publications"},"_namespace":null},{"id":12826,"version":3,"created":1554957844000,"modified":1554958212000,"deprecated":false,"name":"Melanocortin receptor 4","accession":"P32245","gene":"MC4R","description":"Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.9511582703440262,"antibodyCount":251,"monoclonalCount":4,"pubmedCount":null,"jensenScore":930.173547,"patentCount":70078,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.801348160886782,"pubTatorScore":2.871624179855083,"self":"https://pharos.nih.gov/idg/api/v1/targets(12826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":574,"href":"https://pharos.nih.gov/idg/api/v1/targets(12826)/properties"},"_links":{"count":1815,"href":"https://pharos.nih.gov/idg/api/v1/targets(12826)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(12826)/synonyms"},"_publications":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(12826)/publications"},"_namespace":null},{"id":12827,"version":2,"created":1554958216000,"modified":1554958219000,"deprecated":false,"name":"Methionyl-tRNA formyltransferase, mitochondrial","accession":"Q96DP5","gene":"MTFMT","description":"Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.427918742843672,"antibodyCount":69,"monoclonalCount":45,"pubmedCount":null,"jensenScore":264.82498,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.245776060935317,"pubTatorScore":1.0536390516090808,"self":"https://pharos.nih.gov/idg/api/v1/targets(12827)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(12827)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(12827)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12827)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12827)/publications"},"_namespace":null},{"id":12828,"version":2,"created":1554958220000,"modified":1554958224000,"deprecated":false,"name":"C-C chemokine receptor type 7","accession":"P32248","gene":"CCR7","description":"Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-2.994802322045657,"antibodyCount":687,"monoclonalCount":307,"pubmedCount":null,"jensenScore":983.058502,"patentCount":56084,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.2146786135218,"pubTatorScore":2.7338872537604395,"self":"https://pharos.nih.gov/idg/api/v1/targets(12828)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":569,"href":"https://pharos.nih.gov/idg/api/v1/targets(12828)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(12828)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12828)/synonyms"},"_publications":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(12828)/publications"},"_namespace":null},{"id":12829,"version":3,"created":1554958225000,"modified":1555040960000,"deprecated":false,"name":"RecQ-mediated genome instability protein 2","accession":"Q96E14","gene":"RMI2","description":"Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3146278823603221,"antibodyCount":12,"monoclonalCount":2,"pubmedCount":null,"jensenScore":20.023458,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.863035910420592,"pubTatorScore":1.2137706366526677,"self":"https://pharos.nih.gov/idg/api/v1/targets(12829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12829)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(12829)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12829)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12829)/publications"},"_namespace":null},{"id":12830,"version":3,"created":1554958229000,"modified":1554958270000,"deprecated":false,"name":"Bombesin receptor subtype-3","accession":"P32247","gene":"BRS3","description":"Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.2060993101413335,"antibodyCount":356,"monoclonalCount":2,"pubmedCount":null,"jensenScore":167.709164,"patentCount":14212,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.561582644371416,"pubTatorScore":1.924873857147193,"self":"https://pharos.nih.gov/idg/api/v1/targets(12830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(12830)/properties"},"_links":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(12830)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12830)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12830)/publications"},"_namespace":null},{"id":12831,"version":3,"created":1554958271000,"modified":1555040961000,"deprecated":false,"name":"Protein FAM122A","accession":"Q96E09","gene":"FAM122A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.11579535535886984,"antibodyCount":44,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.055556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":28.11318311925804,"pubTatorScore":-0.2596373105057561,"self":"https://pharos.nih.gov/idg/api/v1/targets(12831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(12831)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(12831)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12831)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12831)/publications"},"_namespace":null},{"id":12832,"version":3,"created":1554958275000,"modified":1555040962000,"deprecated":false,"name":"Kit ligand","accession":"P21583","gene":"KITLG","description":"Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.243059763953276,"antibodyCount":695,"monoclonalCount":214,"pubmedCount":null,"jensenScore":1696.995271,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":47.246572334256626,"pubTatorScore":3.284395624059446,"self":"https://pharos.nih.gov/idg/api/v1/targets(12832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":602,"href":"https://pharos.nih.gov/idg/api/v1/targets(12832)/properties"},"_links":{"count":1157,"href":"https://pharos.nih.gov/idg/api/v1/targets(12832)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(12832)/synonyms"},"_publications":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12832)/publications"},"_namespace":null},{"id":12833,"version":2,"created":1554958282000,"modified":1554958282000,"deprecated":false,"name":"Protein FAM236D","accession":"A0A1B0GTK5","gene":"FAM236D","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12833)/properties"},"_links":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(12833)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12833)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12833)/publications"},"_namespace":null},{"id":12834,"version":2,"created":1554958282000,"modified":1554958286000,"deprecated":false,"name":"Thioredoxin-like protein 4A","accession":"P83876","gene":"TXNL4A","description":"Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1354552802210092,"antibodyCount":28,"monoclonalCount":10,"pubmedCount":null,"jensenScore":11.050401,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.334816656817786,"pubTatorScore":1.4007472292022538,"self":"https://pharos.nih.gov/idg/api/v1/targets(12834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(12834)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(12834)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12834)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12834)/publications"},"_namespace":null},{"id":12835,"version":3,"created":1554958287000,"modified":1555040967000,"deprecated":false,"name":"5'-nucleotidase","accession":"P21589","gene":"NT5E","description":"Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.883103486441099,"antibodyCount":835,"monoclonalCount":454,"pubmedCount":null,"jensenScore":784.499257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":43.18334817246215,"pubTatorScore":2.7375598846134954,"self":"https://pharos.nih.gov/idg/api/v1/targets(12835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":597,"href":"https://pharos.nih.gov/idg/api/v1/targets(12835)/properties"},"_links":{"count":1285,"href":"https://pharos.nih.gov/idg/api/v1/targets(12835)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12835)/synonyms"},"_publications":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(12835)/publications"},"_namespace":null},{"id":12836,"version":2,"created":1554958299000,"modified":1554958303000,"deprecated":false,"name":"F-actin-uncapping protein LRRC16A","accession":"Q5VZK9","gene":"CARMIL1","description":"Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3282177208130872,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.078525,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.2715658697590244,"self":"https://pharos.nih.gov/idg/api/v1/targets(12836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(12836)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(12836)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12836)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(12836)/publications"},"_namespace":null},{"id":12837,"version":2,"created":1554958304000,"modified":1554958305000,"deprecated":false,"name":"Protein FAM237A","accession":"A0A1B0GTK4","gene":"FAM237A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12837)/properties"},"_links":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(12837)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12837)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12837)/publications"},"_namespace":null},{"id":12838,"version":4,"created":1554958305000,"modified":1555040969000,"deprecated":false,"name":"Gastrin/cholecystokinin type B receptor","accession":"P32239","gene":"CCKBR","description":"Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.7510023207832806,"antibodyCount":234,"monoclonalCount":2,"pubmedCount":null,"jensenScore":529.524606,"patentCount":15589,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":34.928834026240466,"pubTatorScore":2.665042261303361,"self":"https://pharos.nih.gov/idg/api/v1/targets(12838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(12838)/properties"},"_links":{"count":1440,"href":"https://pharos.nih.gov/idg/api/v1/targets(12838)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12838)/synonyms"},"_publications":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12838)/publications"},"_namespace":null},{"id":12839,"version":4,"created":1554958522000,"modified":1555040972000,"deprecated":false,"name":"Cholecystokinin receptor type A","accession":"P32238","gene":"CCKAR","description":"Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.7691476276778966,"antibodyCount":307,"monoclonalCount":18,"pubmedCount":null,"jensenScore":539.13388,"patentCount":16627,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.774596050023185,"pubTatorScore":2.408662589397648,"self":"https://pharos.nih.gov/idg/api/v1/targets(12839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(12839)/properties"},"_links":{"count":691,"href":"https://pharos.nih.gov/idg/api/v1/targets(12839)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(12839)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12839)/publications"},"_namespace":null},{"id":12840,"version":3,"created":1554958591000,"modified":1555040973000,"deprecated":false,"name":"Uncharacterized protein C9orf43","accession":"Q8TAL5","gene":"C9orf43","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":67,"monoclonalCount":5,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(12840)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(12840)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(12840)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12840)/publications"},"_namespace":null},{"id":12841,"version":2,"created":1554958594000,"modified":1554958597000,"deprecated":false,"name":"Fin bud initiation factor homolog","accession":"Q8TAL6","gene":"FIBIN","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.605049744705264,"antibodyCount":34,"monoclonalCount":1,"pubmedCount":null,"jensenScore":3.850846,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.100598288688165,"pubTatorScore":0.14760275068793643,"self":"https://pharos.nih.gov/idg/api/v1/targets(12841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(12841)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(12841)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12841)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12841)/publications"},"_namespace":null},{"id":12842,"version":3,"created":1554958598000,"modified":1555040974000,"deprecated":false,"name":"Serine hydroxymethyltransferase, cytosolic","accession":"P34896","gene":"SHMT1","description":"Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.586898144900916,"antibodyCount":181,"monoclonalCount":39,"pubmedCount":null,"jensenScore":370.397832,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":49.37423744984247,"pubTatorScore":2.1848634142754877,"self":"https://pharos.nih.gov/idg/api/v1/targets(12842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":513,"href":"https://pharos.nih.gov/idg/api/v1/targets(12842)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(12842)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(12842)/synonyms"},"_publications":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12842)/publications"},"_namespace":null},{"id":12843,"version":3,"created":1554958603000,"modified":1555040976000,"deprecated":false,"name":"Serine hydroxymethyltransferase, mitochondrial","accession":"P34897","gene":"SHMT2","description":"Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Interconversion of serine and glycine (PubMed:25619277). Associates with mitochondrial DNA (PubMed:18063578). Plays a role in the deubiquitination of target proteins as component of the BRISC complex (PubMed:24075985). Required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.392266259906378,"antibodyCount":137,"monoclonalCount":22,"pubmedCount":null,"jensenScore":240.346525,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.51100559052043,"pubTatorScore":1.7164952208520101,"self":"https://pharos.nih.gov/idg/api/v1/targets(12843)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(12843)/properties"},"_links":{"count":1265,"href":"https://pharos.nih.gov/idg/api/v1/targets(12843)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12843)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12843)/publications"},"_namespace":null},{"id":12844,"version":2,"created":1554958610000,"modified":1554958613000,"deprecated":false,"name":"POU domain, class 3, transcription factor 3","accession":"P20264","gene":"POU3F3","description":"Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1600093980438944,"antibodyCount":126,"monoclonalCount":0,"pubmedCount":null,"jensenScore":134.039578,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.041702887365997,"pubTatorScore":1.915691463908389,"self":"https://pharos.nih.gov/idg/api/v1/targets(12844)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(12844)/properties"},"_links":{"count":689,"href":"https://pharos.nih.gov/idg/api/v1/targets(12844)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12844)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12844)/publications"},"_namespace":null},{"id":12845,"version":2,"created":1554958613000,"modified":1554958616000,"deprecated":false,"name":"POU domain, class 3, transcription factor 2","accession":"P20265","gene":"POU3F2","description":"Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.0950914177655338,"antibodyCount":272,"monoclonalCount":81,"pubmedCount":null,"jensenScore":119.725851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.484244440046417,"pubTatorScore":2.1816802167800646,"self":"https://pharos.nih.gov/idg/api/v1/targets(12845)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(12845)/properties"},"_links":{"count":667,"href":"https://pharos.nih.gov/idg/api/v1/targets(12845)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12845)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(12845)/publications"},"_namespace":null},{"id":12846,"version":2,"created":1554958617000,"modified":1554958620000,"deprecated":false,"name":"Zinc finger MYM-type protein 4","accession":"Q5VZL5","gene":"ZMYM4","description":"Plays a role in the regulation of cell morphology and cytoskeletal organization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8711449613135768,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.97117,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.520214834334,"pubTatorScore":0.7715525007630208,"self":"https://pharos.nih.gov/idg/api/v1/targets(12846)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(12846)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(12846)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12846)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12846)/publications"},"_namespace":null},{"id":12847,"version":3,"created":1554958621000,"modified":1555040978000,"deprecated":false,"name":"Myc-associated zinc finger protein","accession":"P56270","gene":"MAZ","description":"May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.207894899303285,"antibodyCount":220,"monoclonalCount":104,"pubmedCount":null,"jensenScore":157.406989,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.828451033632376,"pubTatorScore":1.899796823433824,"self":"https://pharos.nih.gov/idg/api/v1/targets(12847)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(12847)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(12847)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12847)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(12847)/publications"},"_namespace":null},{"id":12848,"version":3,"created":1554958626000,"modified":1555040979000,"deprecated":false,"name":"39S ribosomal protein L38, mitochondrial","accession":"Q96DV4","gene":"MRPL38","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2596373109400506,"antibodyCount":67,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.438096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":35,"knowledgeAvailability":32.84368086662835,"pubTatorScore":-0.2944989210808428,"self":"https://pharos.nih.gov/idg/api/v1/targets(12848)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(12848)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(12848)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12848)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12848)/publications"},"_namespace":null},{"id":12849,"version":2,"created":1554958629000,"modified":1554958632000,"deprecated":false,"name":"DENN domain-containing protein 3","accession":"A2RUS2","gene":"DENND3","description":"Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6507930341146761,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.952338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.8548351710744,"pubTatorScore":0.2810915724504855,"self":"https://pharos.nih.gov/idg/api/v1/targets(12849)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(12849)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(12849)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12849)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12849)/publications"},"_namespace":null},{"id":12850,"version":2,"created":1554958633000,"modified":1554958637000,"deprecated":false,"name":"DEP domain-containing mTOR-interacting protein","accession":"Q8TB45","gene":"DEPTOR","description":"Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6138644956799566,"antibodyCount":180,"monoclonalCount":22,"pubmedCount":null,"jensenScore":50.193713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.813243127513466,"pubTatorScore":1.5040127699324122,"self":"https://pharos.nih.gov/idg/api/v1/targets(12850)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(12850)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(12850)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12850)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(12850)/publications"},"_namespace":null},{"id":12851,"version":2,"created":1554958638000,"modified":1554958640000,"deprecated":false,"name":"Protein ABHD4","accession":"Q8TB40","gene":"ABHD4","description":"Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5471591263218041,"antibodyCount":189,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.707035,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.87484778754303,"pubTatorScore":0.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(12851)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(12851)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(12851)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12851)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12851)/publications"},"_namespace":null},{"id":12852,"version":2,"created":1554958641000,"modified":1554958645000,"deprecated":false,"name":"Serine/threonine-protein kinase Kist","accession":"Q8TAS1","gene":"UHMK1","description":"Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.7345571485051665,"antibodyCount":231,"monoclonalCount":30,"pubmedCount":null,"jensenScore":537.462536,"patentCount":6144,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.936748094704676,"pubTatorScore":1.766511414824215,"self":"https://pharos.nih.gov/idg/api/v1/targets(12852)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12852)/properties"},"_links":{"count":956,"href":"https://pharos.nih.gov/idg/api/v1/targets(12852)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12852)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12852)/publications"},"_namespace":null},{"id":12853,"version":2,"created":1554958646000,"modified":1554958647000,"deprecated":false,"name":"Testis-expressed protein 36","accession":"Q5VZQ5","gene":"TEX36","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.137974147544593,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12853)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12853)/properties"},"_links":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12853)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12853)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12853)/publications"},"_namespace":null},{"id":12854,"version":2,"created":1554958647000,"modified":1554958650000,"deprecated":false,"name":"Protein lin-54 homolog","accession":"Q6MZP7","gene":"LIN54","description":"Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.2911916373104944,"antibodyCount":45,"monoclonalCount":1,"pubmedCount":null,"jensenScore":19.5301,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.764458220821034,"pubTatorScore":0.6452517605590112,"self":"https://pharos.nih.gov/idg/api/v1/targets(12854)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(12854)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(12854)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12854)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12854)/publications"},"_namespace":null},{"id":12855,"version":3,"created":1554958651000,"modified":1555040981000,"deprecated":false,"name":"Uncharacterized protein C6orf136","accession":"Q5SQH8","gene":"C6orf136","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":64,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(12855)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(12855)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(12855)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12855)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12855)/publications"},"_namespace":null},{"id":12856,"version":2,"created":1554958655000,"modified":1554958658000,"deprecated":false,"name":"Nucleolar protein 11","accession":"Q9H8H0","gene":"NOL11","description":"Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.09691001300805639,"antibodyCount":15,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.658333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.99327440569712,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(12856)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(12856)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(12856)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12856)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12856)/publications"},"_namespace":null},{"id":12857,"version":2,"created":1554958659000,"modified":1554958663000,"deprecated":false,"name":"Methyltransferase-like protein 7A","accession":"Q9H8H3","gene":"METTL7A","description":"Probable methyltransferase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8472859193409382,"antibodyCount":180,"monoclonalCount":5,"pubmedCount":null,"jensenScore":7.323352,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.933397443704806,"pubTatorScore":0.5228787018508873,"self":"https://pharos.nih.gov/idg/api/v1/targets(12857)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(12857)/properties"},"_links":{"count":1004,"href":"https://pharos.nih.gov/idg/api/v1/targets(12857)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12857)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12857)/publications"},"_namespace":null},{"id":12858,"version":3,"created":1554958664000,"modified":1555040986000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX31","accession":"Q9H8H2","gene":"DDX31","description":"Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.6020599913279624,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":59,"knowledgeAvailability":36.115533028025254,"pubTatorScore":0.03476197263012007,"self":"https://pharos.nih.gov/idg/api/v1/targets(12858)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(12858)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(12858)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12858)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12858)/publications"},"_namespace":null},{"id":12859,"version":2,"created":1554958668000,"modified":1554958672000,"deprecated":false,"name":"SLAM family member 6","accession":"Q96DU3","gene":"SLAMF6","description":"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8360840380739825,"antibodyCount":241,"monoclonalCount":83,"pubmedCount":null,"jensenScore":67.893438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.641406155031877,"pubTatorScore":1.534560188311135,"self":"https://pharos.nih.gov/idg/api/v1/targets(12859)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(12859)/properties"},"_links":{"count":838,"href":"https://pharos.nih.gov/idg/api/v1/targets(12859)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12859)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12859)/publications"},"_namespace":null},{"id":12860,"version":2,"created":1554958673000,"modified":1554958673000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC01560","accession":"Q8TB33","gene":"LINC01560","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.376298285517487,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12860)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12860)/properties"},"_links":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(12860)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12860)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12860)/publications"},"_namespace":null},{"id":12861,"version":2,"created":1554958673000,"modified":1554958675000,"deprecated":false,"name":"Hippocampus abundant transcript-like protein 2","accession":"Q5VZR4","gene":"MFSD14C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12861)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(12861)/properties"},"_links":{"count":739,"href":"https://pharos.nih.gov/idg/api/v1/targets(12861)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12861)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12861)/publications"},"_namespace":null},{"id":12862,"version":3,"created":1554958675000,"modified":1555040987000,"deprecated":false,"name":"Transmembrane protein 89","accession":"A2RUT3","gene":"TMEM89","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":5,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":8.51340021183411,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12862)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(12862)/properties"},"_links":{"count":516,"href":"https://pharos.nih.gov/idg/api/v1/targets(12862)/links"},"_synonyms":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(12862)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12862)/publications"},"_namespace":null},{"id":12863,"version":3,"created":1554958677000,"modified":1555040988000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 51","accession":"Q96E66","gene":"LRTOMT","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9291349899600027,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.098949,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.1025377729478731,"self":"https://pharos.nih.gov/idg/api/v1/targets(12863)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(12863)/properties"},"_links":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(12863)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12863)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12863)/publications"},"_namespace":null},{"id":12864,"version":3,"created":1554958677000,"modified":1555040988000,"deprecated":false,"name":"Alpha-tubulin N-acetyltransferase 1","accession":"Q5SQI0","gene":"ATAT1","description":"Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.044032429122344,"antibodyCount":80,"monoclonalCount":2,"pubmedCount":null,"jensenScore":72.252791,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.476633667116594,"pubTatorScore":1.2494312969577928,"self":"https://pharos.nih.gov/idg/api/v1/targets(12864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(12864)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(12864)/links"},"_synonyms":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(12864)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12864)/publications"},"_namespace":null},{"id":12865,"version":2,"created":1554958681000,"modified":1554958684000,"deprecated":false,"name":"NUT family member 2G","accession":"Q5VZR2","gene":"NUTM2G","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.39370790006058,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12865)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(12865)/properties"},"_links":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(12865)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12865)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12865)/publications"},"_namespace":null},{"id":12866,"version":2,"created":1554958684000,"modified":1554958687000,"deprecated":false,"name":"Proline-rich protein 5-like","accession":"Q6MZQ0","gene":"PRR5L","description":"Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4326384737381212,"antibodyCount":54,"monoclonalCount":1,"pubmedCount":null,"jensenScore":3.334324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.882064090100727,"pubTatorScore":0.022909416790508605,"self":"https://pharos.nih.gov/idg/api/v1/targets(12866)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(12866)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(12866)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12866)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12866)/publications"},"_namespace":null},{"id":12867,"version":2,"created":1554958688000,"modified":1554958691000,"deprecated":false,"name":"Cathepsin W","accession":"P56202","gene":"CTSW","description":"May have a specific function in the mechanism or regulation of T-cell cytolytic activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1731862940356492,"antibodyCount":61,"monoclonalCount":25,"pubmedCount":null,"jensenScore":15.915072,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.029205671577206,"pubTatorScore":1.2973956818126184,"self":"https://pharos.nih.gov/idg/api/v1/targets(12867)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(12867)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(12867)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12867)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12867)/publications"},"_namespace":null},{"id":12868,"version":3,"created":1554958692000,"modified":1555040990000,"deprecated":false,"name":"Neuronal acetylcholine receptor subunit alpha-3","accession":"P32297","gene":"CHRNA3","description":"After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.9957723751441452,"antibodyCount":193,"monoclonalCount":1,"pubmedCount":null,"jensenScore":92.138833,"patentCount":2328,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":41.49193387041581,"pubTatorScore":2.044314205787865,"self":"https://pharos.nih.gov/idg/api/v1/targets(12868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":564,"href":"https://pharos.nih.gov/idg/api/v1/targets(12868)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(12868)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(12868)/synonyms"},"_publications":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(12868)/publications"},"_namespace":null},{"id":12869,"version":2,"created":1554958713000,"modified":1554958720000,"deprecated":false,"name":"G protein-coupled receptor kinase 4","accession":"P32298","gene":"GRK4","description":"Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.7137890411387775,"antibodyCount":171,"monoclonalCount":92,"pubmedCount":null,"jensenScore":54.81598,"patentCount":4474,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.815284867277356,"pubTatorScore":1.8864215427556899,"self":"https://pharos.nih.gov/idg/api/v1/targets(12869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(12869)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(12869)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(12869)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12869)/publications"},"_namespace":null},{"id":12870,"version":2,"created":1554958720000,"modified":1554958725000,"deprecated":false,"name":"Ganglioside-induced differentiation-associated protein 1","accession":"Q8TB36","gene":"GDAP1","description":"Regulates the mitochondrial network by promoting mitochondrial fission.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.990499813300051,"antibodyCount":77,"monoclonalCount":3,"pubmedCount":null,"jensenScore":105.862027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.19856553682592,"pubTatorScore":2.054041508626029,"self":"https://pharos.nih.gov/idg/api/v1/targets(12870)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(12870)/properties"},"_links":{"count":1120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12870)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12870)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12870)/publications"},"_namespace":null},{"id":12871,"version":3,"created":1554958726000,"modified":1555040992000,"deprecated":false,"name":"Inositol-trisphosphate 3-kinase C","accession":"Q96DU7","gene":"ITPKC","description":"Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.3587730515602945,"antibodyCount":143,"monoclonalCount":4,"pubmedCount":null,"jensenScore":23.39868,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.435974902474626,"pubTatorScore":1.5063331747323374,"self":"https://pharos.nih.gov/idg/api/v1/targets(12871)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(12871)/properties"},"_links":{"count":980,"href":"https://pharos.nih.gov/idg/api/v1/targets(12871)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12871)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12871)/publications"},"_namespace":null},{"id":12872,"version":2,"created":1554958731000,"modified":1554958734000,"deprecated":false,"name":"Iron-sulfur protein NUBPL","accession":"Q8TB37","gene":"NUBPL","description":"Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7545633403710934,"antibodyCount":135,"monoclonalCount":51,"pubmedCount":null,"jensenScore":57.948705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.82003702338897,"pubTatorScore":1.5161947058500698,"self":"https://pharos.nih.gov/idg/api/v1/targets(12872)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(12872)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(12872)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12872)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12872)/publications"},"_namespace":null},{"id":12873,"version":2,"created":1554958735000,"modified":1554958738000,"deprecated":false,"name":"Polyadenylate-binding protein 5","accession":"Q96DU9","gene":"PABPC5","description":"Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4223344481962464,"antibodyCount":63,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.557358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.486101419990245,"pubTatorScore":0.6491725035029869,"self":"https://pharos.nih.gov/idg/api/v1/targets(12873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(12873)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(12873)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12873)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12873)/publications"},"_namespace":null},{"id":12874,"version":3,"created":1554958739000,"modified":1555040993000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 10","accession":"Q16322","gene":"KCNA10","description":"Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.0984445862248833,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.322005,"patentCount":5611,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":21.345568938680458,"pubTatorScore":0.9412636053828163,"self":"https://pharos.nih.gov/idg/api/v1/targets(12874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(12874)/properties"},"_links":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(12874)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12874)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12874)/publications"},"_namespace":null},{"id":12875,"version":2,"created":1554958747000,"modified":1554958750000,"deprecated":false,"name":"Caspase activity and apoptosis inhibitor 1","accession":"Q9H8G2","gene":"CAAP1","description":"Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.5959108643207924,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.682828,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.911986453822983,"pubTatorScore":1.205023812625178,"self":"https://pharos.nih.gov/idg/api/v1/targets(12875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(12875)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(12875)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12875)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12875)/publications"},"_namespace":null},{"id":12876,"version":2,"created":1554958750000,"modified":1554958753000,"deprecated":false,"name":"Zinc finger protein 430","accession":"Q9H8G1","gene":"ZNF430","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.088983199454542,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(12876)/properties"},"_links":{"count":832,"href":"https://pharos.nih.gov/idg/api/v1/targets(12876)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12876)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12876)/publications"},"_namespace":null},{"id":12877,"version":3,"created":1554958754000,"modified":1555040994000,"deprecated":false,"name":"Spermatogenesis-associated protein 20","accession":"Q8TB22","gene":"SPATA20","description":"May play a role in fertility regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4121804524915048,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.128205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":30.119392759050925,"pubTatorScore":0.2825466654994366,"self":"https://pharos.nih.gov/idg/api/v1/targets(12877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(12877)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(12877)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12877)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12877)/publications"},"_namespace":null},{"id":12878,"version":3,"created":1554958758000,"modified":1555040996000,"deprecated":false,"name":"SWI/SNF complex subunit SMARCC2","accession":"Q8TAQ2","gene":"SMARCC2","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-1.2778678622089,"antibodyCount":140,"monoclonalCount":7,"pubmedCount":null,"jensenScore":15.186487,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":50.35608389926977,"pubTatorScore":1.0576605135683468,"self":"https://pharos.nih.gov/idg/api/v1/targets(12878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(12878)/properties"},"_links":{"count":1200,"href":"https://pharos.nih.gov/idg/api/v1/targets(12878)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12878)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12878)/publications"},"_namespace":null},{"id":12879,"version":2,"created":1554958763000,"modified":1554958767000,"deprecated":false,"name":"Metalloendopeptidase OMA1, mitochondrial","accession":"Q96E52","gene":"OMA1","description":"Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7737138795674225,"antibodyCount":40,"monoclonalCount":3,"pubmedCount":null,"jensenScore":54.686451,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.959738902182416,"pubTatorScore":1.042566141343014,"self":"https://pharos.nih.gov/idg/api/v1/targets(12879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(12879)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(12879)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12879)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12879)/publications"},"_namespace":null},{"id":12880,"version":2,"created":1554958768000,"modified":1554958771000,"deprecated":false,"name":"Dynein heavy chain 11, axonemal","accession":"Q96DT5","gene":"DNAH11","description":"Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2647899838883585,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.855071,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.15710656912626,"pubTatorScore":1.288603382235533,"self":"https://pharos.nih.gov/idg/api/v1/targets(12880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(12880)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(12880)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12880)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12880)/publications"},"_namespace":null},{"id":12881,"version":2,"created":1554958772000,"modified":1554958775000,"deprecated":false,"name":"Ras and Rab interactor 3","accession":"Q8TB24","gene":"RIN3","description":"Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3041688395954505,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":18.722373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.946990164662324,"pubTatorScore":0.9272215685917398,"self":"https://pharos.nih.gov/idg/api/v1/targets(12881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(12881)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(12881)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12881)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12881)/publications"},"_namespace":null},{"id":12882,"version":2,"created":1554958776000,"modified":1554958780000,"deprecated":false,"name":"cAMP-regulated phosphoprotein 19","accession":"P56211","gene":"ARPP19","description":"Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.326368375167933,"antibodyCount":25,"monoclonalCount":2,"pubmedCount":null,"jensenScore":21.700584,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.45720015947212,"pubTatorScore":1.0515199923931382,"self":"https://pharos.nih.gov/idg/api/v1/targets(12882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(12882)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(12882)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12882)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12882)/publications"},"_namespace":null},{"id":12883,"version":3,"created":1554958781000,"modified":1555040997000,"deprecated":false,"name":"Galectin-12","accession":"Q96DT0","gene":"LGALS12","description":"Binds lactose. May participate in the apoptosis of adipocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1281837759316107,"antibodyCount":70,"monoclonalCount":2,"pubmedCount":null,"jensenScore":15.662229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":20.74143307915904,"pubTatorScore":0.8129133566428556,"self":"https://pharos.nih.gov/idg/api/v1/targets(12883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(12883)/properties"},"_links":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(12883)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12883)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12883)/publications"},"_namespace":null},{"id":12884,"version":2,"created":1554958784000,"modified":1554958786000,"deprecated":false,"name":"Rhomboid-related protein 3","accession":"P58872","gene":"RHBDL3","description":"May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4771212590626073,"antibodyCount":4,"monoclonalCount":1,"pubmedCount":null,"jensenScore":3.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.354168272882387,"pubTatorScore":0.7160033436347992,"self":"https://pharos.nih.gov/idg/api/v1/targets(12884)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(12884)/properties"},"_links":{"count":720,"href":"https://pharos.nih.gov/idg/api/v1/targets(12884)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12884)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12884)/publications"},"_namespace":null},{"id":12885,"version":2,"created":1554958787000,"modified":1554958789000,"deprecated":false,"name":"SUN domain-containing protein 3","accession":"Q8TAQ9","gene":"SUN3","description":"As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.075546979198605,"antibodyCount":31,"monoclonalCount":1,"pubmedCount":null,"jensenScore":11.696704,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.468090594735873,"pubTatorScore":1.0071785561487958,"self":"https://pharos.nih.gov/idg/api/v1/targets(12885)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(12885)/properties"},"_links":{"count":610,"href":"https://pharos.nih.gov/idg/api/v1/targets(12885)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12885)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12885)/publications"},"_namespace":null},{"id":12886,"version":3,"created":1554958790000,"modified":1555040998000,"deprecated":false,"name":"Uncharacterized protein C17orf102","accession":"A2RUQ5","gene":"C17orf102","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12886)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(12886)/properties"},"_links":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12886)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12886)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12886)/publications"},"_namespace":null},{"id":12887,"version":3,"created":1554958790000,"modified":1555040998000,"deprecated":false,"name":"Zinc finger protein 420","accession":"Q8TAQ5","gene":"ZNF420","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.10645532850153967,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.479532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.735817248457263,"pubTatorScore":0.7455951644166025,"self":"https://pharos.nih.gov/idg/api/v1/targets(12887)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(12887)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(12887)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12887)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12887)/publications"},"_namespace":null},{"id":12888,"version":2,"created":1554958794000,"modified":1554958799000,"deprecated":false,"name":"Histone H2B type 1-D","accession":"P58876","gene":"HIST1H2BD","description":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.073995909983698,"antibodyCount":71,"monoclonalCount":1,"pubmedCount":null,"jensenScore":11.596038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.17109947977472,"pubTatorScore":0.403000859137074,"self":"https://pharos.nih.gov/idg/api/v1/targets(12888)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":489,"href":"https://pharos.nih.gov/idg/api/v1/targets(12888)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(12888)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(12888)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12888)/publications"},"_namespace":null},{"id":12889,"version":2,"created":1554958800000,"modified":1554958805000,"deprecated":false,"name":"Zinc finger and BTB domain-containing protein 10","accession":"Q96DT7","gene":"ZBTB10","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1326638220992042,"antibodyCount":101,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.652815,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.96385801875294,"pubTatorScore":0.932877633053235,"self":"https://pharos.nih.gov/idg/api/v1/targets(12889)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(12889)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(12889)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12889)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(12889)/publications"},"_namespace":null},{"id":12890,"version":3,"created":1554958806000,"modified":1555041000000,"deprecated":false,"name":"Cysteine protease ATG4C","accession":"Q96DT6","gene":"ATG4C","description":"Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1896834548242525,"antibodyCount":343,"monoclonalCount":41,"pubmedCount":null,"jensenScore":146.489421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":32.170941584904284,"pubTatorScore":0.5900948256593304,"self":"https://pharos.nih.gov/idg/api/v1/targets(12890)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(12890)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(12890)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12890)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12890)/publications"},"_namespace":null},{"id":12891,"version":2,"created":1554958811000,"modified":1554958812000,"deprecated":false,"name":"HLA class I histocompatibility antigen protein P5","accession":"Q6MZN7","gene":"HCP5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.301550188395648,"pubTatorScore":-0.2730015434978737,"self":"https://pharos.nih.gov/idg/api/v1/targets(12891)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12891)/properties"},"_links":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(12891)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12891)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(12891)/publications"},"_namespace":null},{"id":12892,"version":3,"created":1554958813000,"modified":1555041001000,"deprecated":false,"name":"Cytochrome b reductase 1","accession":"Q53TN4","gene":"CYBRD1","description":"Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8113400466383032,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":60.252925,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":35.23707933977778,"pubTatorScore":1.5530673645839748,"self":"https://pharos.nih.gov/idg/api/v1/targets(12892)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(12892)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(12892)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12892)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12892)/publications"},"_namespace":null},{"id":12893,"version":2,"created":1554958818000,"modified":1554958820000,"deprecated":false,"name":"Collagen alpha-5(VI) chain","accession":"A8TX70","gene":"COL6A5","description":"Collagen VI acts as a cell-binding protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.979678418986933,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.953268,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.680219955778767,"pubTatorScore":1.0703897058668814,"self":"https://pharos.nih.gov/idg/api/v1/targets(12893)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(12893)/properties"},"_links":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(12893)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12893)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12893)/publications"},"_namespace":null},{"id":12894,"version":2,"created":1554958821000,"modified":1554958825000,"deprecated":false,"name":"PCNA-associated factor","accession":"Q15004","gene":"PCLAF","description":"PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3760068421945992,"antibodyCount":146,"monoclonalCount":39,"pubmedCount":null,"jensenScore":2381.275236,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.82520219715066,"self":"https://pharos.nih.gov/idg/api/v1/targets(12894)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(12894)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(12894)/links"},"_synonyms":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(12894)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(12894)/publications"},"_namespace":null},{"id":12895,"version":2,"created":1554958827000,"modified":1554958831000,"deprecated":false,"name":"Condensin complex subunit 2","accession":"Q15003","gene":"NCAPH","description":"Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5424933929033382,"antibodyCount":257,"monoclonalCount":15,"pubmedCount":null,"jensenScore":35.648218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.065491268040795,"pubTatorScore":1.0554594481732706,"self":"https://pharos.nih.gov/idg/api/v1/targets(12895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(12895)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(12895)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(12895)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12895)/publications"},"_namespace":null},{"id":12896,"version":2,"created":1554958832000,"modified":1554958836000,"deprecated":false,"name":"26S proteasome non-ATPase regulatory subunit 6","accession":"Q15008","gene":"PSMD6","description":"Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3595217432296478,"antibodyCount":223,"monoclonalCount":9,"pubmedCount":null,"jensenScore":23.124336,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.6445863258322,"pubTatorScore":0.8875210923273243,"self":"https://pharos.nih.gov/idg/api/v1/targets(12896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(12896)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(12896)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(12896)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12896)/publications"},"_namespace":null},{"id":12897,"version":3,"created":1554958837000,"modified":1555041003000,"deprecated":false,"name":"Pre-mRNA-splicing regulator WTAP","accession":"Q15007","gene":"WTAP","description":"Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1848348281260888,"antibodyCount":201,"monoclonalCount":32,"pubmedCount":null,"jensenScore":15.854284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":42.22605025612904,"pubTatorScore":1.3161659227533595,"self":"https://pharos.nih.gov/idg/api/v1/targets(12897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(12897)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(12897)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12897)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(12897)/publications"},"_namespace":null},{"id":12898,"version":3,"created":1554958841000,"modified":1555041004000,"deprecated":false,"name":"ER membrane protein complex subunit 2","accession":"Q15006","gene":"EMC2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6977273780729073,"antibodyCount":90,"monoclonalCount":11,"pubmedCount":null,"jensenScore":4.713889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":32.250955751330025,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(12898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(12898)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(12898)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12898)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12898)/publications"},"_namespace":null},{"id":12899,"version":2,"created":1554958845000,"modified":1554958848000,"deprecated":false,"name":"Signal peptidase complex subunit 2","accession":"Q15005","gene":"SPCS2","description":"Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.26503233962877015,"antibodyCount":51,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.683333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.780876123610724,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(12899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(12899)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(12899)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12899)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12899)/publications"},"_namespace":null},{"id":12900,"version":2,"created":1554958849000,"modified":1554958850000,"deprecated":false,"name":"Protein myomixer","accession":"A0A1B0GTQ4","gene":"MYMX","description":"Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Probably acts by mediating the mixing of cell membranes. Associates with MYMK to promote myoblast fusion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12900)/properties"},"_links":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(12900)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12900)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12900)/publications"},"_namespace":null},{"id":12901,"version":3,"created":1554958850000,"modified":1555041005000,"deprecated":false,"name":"Sperm acrosome-associated protein 9","accession":"Q96E40","gene":"SPACA9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5093059379876602,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.253968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":-0.5093056708330032,"self":"https://pharos.nih.gov/idg/api/v1/targets(12901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(12901)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(12901)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12901)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12901)/publications"},"_namespace":null},{"id":12902,"version":2,"created":1554958853000,"modified":1554958856000,"deprecated":false,"name":"Inactive dual specificity phosphatase 27","accession":"Q5VZP5","gene":"DUSP27","description":"May be required for myofiber maturation.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.29091750469100175,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.093511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.921551469613878,"pubTatorScore":0.5513918034932231,"self":"https://pharos.nih.gov/idg/api/v1/targets(12902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12902)/properties"},"_links":{"count":755,"href":"https://pharos.nih.gov/idg/api/v1/targets(12902)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12902)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12902)/publications"},"_namespace":null},{"id":12903,"version":2,"created":1554958856000,"modified":1554958859000,"deprecated":false,"name":"Protein phosphatase 1 regulatory subunit 35","accession":"Q8TAP8","gene":"PPP1R35","description":"Inhibits PPP1CA phosphatase activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.34061405099489,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12903)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(12903)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12903)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12903)/publications"},"_namespace":null},{"id":12904,"version":3,"created":1554958859000,"modified":1555041006000,"deprecated":false,"name":"M-phase-specific PLK1-interacting protein","accession":"Q8TAP9","gene":"MPLKIP","description":"May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7463066099831384,"antibodyCount":50,"monoclonalCount":2,"pubmedCount":null,"jensenScore":53.52664,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.974282621466365,"pubTatorScore":1.0717146980980883,"self":"https://pharos.nih.gov/idg/api/v1/targets(12904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(12904)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(12904)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12904)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(12904)/publications"},"_namespace":null},{"id":12905,"version":2,"created":1554958863000,"modified":1554958865000,"deprecated":false,"name":"Coiled-coil domain-containing protein 144A","accession":"A2RUR9","gene":"CCDC144A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.709670896569468,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12905)/properties"},"_links":{"count":843,"href":"https://pharos.nih.gov/idg/api/v1/targets(12905)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(12905)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12905)/publications"},"_namespace":null},{"id":12906,"version":3,"created":1554958866000,"modified":1555041007000,"deprecated":false,"name":"Membrane-spanning 4-domains subfamily A member 6E","accession":"Q96DS6","gene":"MS4A6E","description":"May be involved in signal transduction as a component of a multimeric receptor complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.038166665657140886,"antibodyCount":29,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.915785,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":11.1806287429525,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(12906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(12906)/properties"},"_links":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(12906)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12906)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12906)/publications"},"_namespace":null},{"id":12907,"version":2,"created":1554958867000,"modified":1554958870000,"deprecated":false,"name":"LIM domain only protein 3","accession":"Q8TAP4","gene":"LMO3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2215802938507363,"antibodyCount":199,"monoclonalCount":133,"pubmedCount":null,"jensenScore":14.748171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.868873296034817,"pubTatorScore":1.0262507791202578,"self":"https://pharos.nih.gov/idg/api/v1/targets(12907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(12907)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(12907)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(12907)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12907)/publications"},"_namespace":null},{"id":12908,"version":3,"created":1554958871000,"modified":1555041008000,"deprecated":false,"name":"Centrosomal protein of 76 kDa","accession":"Q8TAP6","gene":"CEP76","description":"Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.03778855931014712,"antibodyCount":97,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.804949,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.3579108351782,"pubTatorScore":0.3553877218534048,"self":"https://pharos.nih.gov/idg/api/v1/targets(12908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(12908)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(12908)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12908)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12908)/publications"},"_namespace":null},{"id":12909,"version":2,"created":1554958875000,"modified":1554958878000,"deprecated":false,"name":"SLC35A4 upstream open reading frame protein","accession":"L0R6Q1","gene":"SLC35A4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.37238590472606703,"antibodyCount":20,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.854279,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.5984256336821929,"self":"https://pharos.nih.gov/idg/api/v1/targets(12909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(12909)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(12909)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(12909)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12909)/publications"},"_namespace":null},{"id":12910,"version":2,"created":1554958878000,"modified":1554958879000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 21","accession":"D6R901","gene":"USP17L21","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.1731818541309256,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12910)/properties"},"_links":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12910)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(12910)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12910)/publications"},"_namespace":null},{"id":12911,"version":2,"created":1554958879000,"modified":1554958881000,"deprecated":false,"name":"Cysteine-rich protein 2-binding protein","accession":"Q9H8E8","gene":"KAT14","description":"Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9008221264409016,"antibodyCount":111,"monoclonalCount":12,"pubmedCount":null,"jensenScore":7.810606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3842137650258072,"self":"https://pharos.nih.gov/idg/api/v1/targets(12911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(12911)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(12911)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12911)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12911)/publications"},"_namespace":null},{"id":12912,"version":3,"created":1554958882000,"modified":1555041009000,"deprecated":false,"name":"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein","accession":"Q15011","gene":"HERPUD1","description":"Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.848005362446377,"antibodyCount":188,"monoclonalCount":42,"pubmedCount":null,"jensenScore":68.919578,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.30424301885972,"pubTatorScore":2.1923231483450425,"self":"https://pharos.nih.gov/idg/api/v1/targets(12912)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(12912)/properties"},"_links":{"count":1179,"href":"https://pharos.nih.gov/idg/api/v1/targets(12912)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(12912)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12912)/publications"},"_namespace":null},{"id":12913,"version":3,"created":1554958888000,"modified":1555041011000,"deprecated":false,"name":"Mortality factor 4-like protein 2","accession":"Q15014","gene":"MORF4L2","description":"Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8795176751091571,"antibodyCount":128,"monoclonalCount":4,"pubmedCount":null,"jensenScore":8.103233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":37.87645366296405,"pubTatorScore":0.7122085340642701,"self":"https://pharos.nih.gov/idg/api/v1/targets(12913)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(12913)/properties"},"_links":{"count":1363,"href":"https://pharos.nih.gov/idg/api/v1/targets(12913)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(12913)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12913)/publications"},"_namespace":null},{"id":12914,"version":2,"created":1554958893000,"modified":1554958896000,"deprecated":false,"name":"MAD2L1-binding protein","accession":"Q15013","gene":"MAD2L1BP","description":"May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.07381231121786622,"antibodyCount":211,"monoclonalCount":42,"pubmedCount":null,"jensenScore":0.914224,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.28507095568382,"pubTatorScore":1.908095153109811,"self":"https://pharos.nih.gov/idg/api/v1/targets(12914)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(12914)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(12914)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12914)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12914)/publications"},"_namespace":null},{"id":12915,"version":3,"created":1554958897000,"modified":1555041014000,"deprecated":false,"name":"Programmed cell death protein 2","accession":"Q16342","gene":"PDCD2","description":"May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2880333340409649,"antibodyCount":68,"monoclonalCount":9,"pubmedCount":null,"jensenScore":22.045445,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":36.43324660477221,"pubTatorScore":2.2046176946912768,"self":"https://pharos.nih.gov/idg/api/v1/targets(12915)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(12915)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(12915)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12915)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12915)/publications"},"_namespace":null},{"id":12916,"version":2,"created":1554958901000,"modified":1554958904000,"deprecated":false,"name":"Lysosomal-associated transmembrane protein 4A","accession":"Q15012","gene":"LAPTM4A","description":"May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2477133320590625,"antibodyCount":88,"monoclonalCount":2,"pubmedCount":null,"jensenScore":173.808932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.907974204308545,"pubTatorScore":1.8835668054182526,"self":"https://pharos.nih.gov/idg/api/v1/targets(12916)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(12916)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(12916)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12916)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12916)/publications"},"_namespace":null},{"id":12917,"version":3,"created":1554958905000,"modified":1555041015000,"deprecated":false,"name":"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial","accession":"P08559","gene":"PDHA1","description":"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.318865539809781,"antibodyCount":436,"monoclonalCount":57,"pubmedCount":null,"jensenScore":204.182081,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.11191695452042,"pubTatorScore":1.985875191307372,"self":"https://pharos.nih.gov/idg/api/v1/targets(12917)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":551,"href":"https://pharos.nih.gov/idg/api/v1/targets(12917)/properties"},"_links":{"count":1324,"href":"https://pharos.nih.gov/idg/api/v1/targets(12917)/links"},"_synonyms":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(12917)/synonyms"},"_publications":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12917)/publications"},"_namespace":null},{"id":12918,"version":2,"created":1554958912000,"modified":1554958916000,"deprecated":false,"name":"Kinesin-like protein KIF26B","accession":"Q2KJY2","gene":"KIF26B","description":"Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9451977966268037,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.411765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.16951273697606,"pubTatorScore":0.8426537899490506,"self":"https://pharos.nih.gov/idg/api/v1/targets(12918)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(12918)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(12918)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12918)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12918)/publications"},"_namespace":null},{"id":12919,"version":2,"created":1554958917000,"modified":1554958920000,"deprecated":false,"name":"Probable C-mannosyltransferase DPY19L1","accession":"Q2PZI1","gene":"DPY19L1","description":"Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.017728766960431602,"antibodyCount":106,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.21544,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.218740312429524,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(12919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(12919)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(12919)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12919)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12919)/publications"},"_namespace":null},{"id":12920,"version":2,"created":1554958921000,"modified":1554958924000,"deprecated":false,"name":"Zinc finger protein 461","accession":"Q8TAF7","gene":"ZNF461","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.21148923001046074,"antibodyCount":86,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.651898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.290420708109973,"pubTatorScore":0.43707069293325634,"self":"https://pharos.nih.gov/idg/api/v1/targets(12920)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(12920)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(12920)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12920)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12920)/publications"},"_namespace":null},{"id":12921,"version":3,"created":1554958924000,"modified":1555041017000,"deprecated":false,"name":"U5 small nuclear ribonucleoprotein 40 kDa protein","accession":"Q96DI7","gene":"SNRNP40","description":"Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6627284743668636,"antibodyCount":103,"monoclonalCount":3,"pubmedCount":null,"jensenScore":441.714638,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":36.506053407438515,"pubTatorScore":2.0969100095337008,"self":"https://pharos.nih.gov/idg/api/v1/targets(12921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(12921)/properties"},"_links":{"count":1114,"href":"https://pharos.nih.gov/idg/api/v1/targets(12921)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(12921)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(12921)/publications"},"_namespace":null},{"id":12922,"version":2,"created":1554958929000,"modified":1554958931000,"deprecated":false,"name":"Alkaline ceramidase 2","accession":"Q5QJU3","gene":"ACER2","description":"Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.0544294513429056,"antibodyCount":46,"monoclonalCount":1,"pubmedCount":null,"jensenScore":10.833079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.768545960229872,"pubTatorScore":1.0014452264457927,"self":"https://pharos.nih.gov/idg/api/v1/targets(12922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12922)/publications"},"_namespace":null},{"id":12923,"version":2,"created":1554958931000,"modified":1554958933000,"deprecated":false,"name":"LHFPL tetraspan subfamily member 5 protein","accession":"Q8TAF8","gene":"LHFPL5","description":"In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.008135360683671,"antibodyCount":64,"monoclonalCount":1,"pubmedCount":null,"jensenScore":98.556749,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.1122553596178,"pubTatorScore":1.4819769262437343,"self":"https://pharos.nih.gov/idg/api/v1/targets(12923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(12923)/properties"},"_links":{"count":481,"href":"https://pharos.nih.gov/idg/api/v1/targets(12923)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(12923)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12923)/publications"},"_namespace":null},{"id":12924,"version":3,"created":1554958934000,"modified":1555041018000,"deprecated":false,"name":"N-alpha-acetyltransferase 35, NatC auxiliary subunit","accession":"Q5VZE5","gene":"NAA35","description":"Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3827750167995574,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.120707,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.662947179473505,"pubTatorScore":0.9535304551571283,"self":"https://pharos.nih.gov/idg/api/v1/targets(12924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(12924)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(12924)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(12924)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12924)/publications"},"_namespace":null},{"id":12925,"version":3,"created":1554958938000,"modified":1555041020000,"deprecated":false,"name":"WD repeat-containing protein 48","accession":"Q8TAF3","gene":"WDR48","description":"Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.305871470446399,"antibodyCount":74,"monoclonalCount":3,"pubmedCount":null,"jensenScore":20.059305,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.93811698491155,"pubTatorScore":1.164636036478466,"self":"https://pharos.nih.gov/idg/api/v1/targets(12925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(12925)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(12925)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(12925)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12925)/publications"},"_namespace":null},{"id":12926,"version":2,"created":1554958943000,"modified":1554958943000,"deprecated":false,"name":"Putative uncharacterized protein LQK1","accession":"Q8TAF5","gene":"FLVCR1-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.344155104768125,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12926)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(12926)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12926)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12926)/publications"},"_namespace":null},{"id":12927,"version":2,"created":1554958943000,"modified":1554958949000,"deprecated":false,"name":"Microtubule-associated protein 1B","accession":"P46821","gene":"MAP1B","description":"Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.6209048804288773,"antibodyCount":168,"monoclonalCount":59,"pubmedCount":null,"jensenScore":412.587687,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.45551300741869,"pubTatorScore":2.232555535247339,"self":"https://pharos.nih.gov/idg/api/v1/targets(12927)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(12927)/properties"},"_links":{"count":1161,"href":"https://pharos.nih.gov/idg/api/v1/targets(12927)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12927)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(12927)/publications"},"_namespace":null},{"id":12928,"version":3,"created":1554958950000,"modified":1555041021000,"deprecated":false,"name":"Pleckstrin","accession":"P08567","gene":"PLEK","description":"Major protein kinase C substrate of platelets.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.006237620003507,"antibodyCount":290,"monoclonalCount":120,"pubmedCount":null,"jensenScore":743.740316,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.73729749204461,"pubTatorScore":2.57568952324598,"self":"https://pharos.nih.gov/idg/api/v1/targets(12928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(12928)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(12928)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12928)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12928)/publications"},"_namespace":null},{"id":12929,"version":3,"created":1554958956000,"modified":1555041022000,"deprecated":false,"name":"Protein disulfide-isomerase","accession":"P07237","gene":"P4HB","description":"This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0318907988718022,"antibodyCount":381,"monoclonalCount":114,"pubmedCount":null,"jensenScore":1042.493915,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":47.31833618451039,"pubTatorScore":2.485223780618097,"self":"https://pharos.nih.gov/idg/api/v1/targets(12929)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":536,"href":"https://pharos.nih.gov/idg/api/v1/targets(12929)/properties"},"_links":{"count":1288,"href":"https://pharos.nih.gov/idg/api/v1/targets(12929)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(12929)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(12929)/publications"},"_namespace":null},{"id":12930,"version":2,"created":1554958963000,"modified":1554958965000,"deprecated":false,"name":"Protein ZNF767","accession":"Q75MW2","gene":"ZNF767P","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5312300143036555,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.943232,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.19291443695358,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(12930)/properties"},"_links":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12930)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12930)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12930)/publications"},"_namespace":null},{"id":12931,"version":3,"created":1554958965000,"modified":1555041024000,"deprecated":false,"name":"Prostaglandin E synthase 2","accession":"Q9H7Z7","gene":"PTGES2","description":"Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.6583372093015396,"antibodyCount":176,"monoclonalCount":25,"pubmedCount":null,"jensenScore":34.908657,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":38.01007920640586,"pubTatorScore":1.3097572651180454,"self":"https://pharos.nih.gov/idg/api/v1/targets(12931)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(12931)/properties"},"_links":{"count":1153,"href":"https://pharos.nih.gov/idg/api/v1/targets(12931)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(12931)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(12931)/publications"},"_namespace":null},{"id":12932,"version":2,"created":1554958974000,"modified":1554958977000,"deprecated":false,"name":"UDP-glucuronosyltransferase 1-6","accession":"P19224","gene":"UGT1A6","description":"UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.766481019324574,"antibodyCount":64,"monoclonalCount":11,"pubmedCount":null,"jensenScore":608.618676,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.99094802116058,"pubTatorScore":2.3012335560610855,"self":"https://pharos.nih.gov/idg/api/v1/targets(12932)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(12932)/properties"},"_links":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(12932)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(12932)/synonyms"},"_publications":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12932)/publications"},"_namespace":null},{"id":12933,"version":2,"created":1554958977000,"modified":1554958980000,"deprecated":false,"name":"Protein NRDE2 homolog","accession":"Q9H7Z3","gene":"NRDE2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.09691001300805639,"antibodyCount":18,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.712031258085194,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12933)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(12933)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(12933)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(12933)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(12933)/publications"},"_namespace":null},{"id":12934,"version":3,"created":1554958981000,"modified":1555041025000,"deprecated":false,"name":"Histone acetyltransferase KAT8","accession":"Q9H7Z6","gene":"KAT8","description":"Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.3102836814287873,"antibodyCount":195,"monoclonalCount":36,"pubmedCount":null,"jensenScore":198.443117,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.47068706788552,"pubTatorScore":2.4349060522961077,"self":"https://pharos.nih.gov/idg/api/v1/targets(12934)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(12934)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(12934)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(12934)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(12934)/publications"},"_namespace":null},{"id":12935,"version":2,"created":1554958986000,"modified":1554958992000,"deprecated":false,"name":"Caldesmon","accession":"Q05682","gene":"CALD1","description":"Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8418486746072973,"antibodyCount":703,"monoclonalCount":361,"pubmedCount":null,"jensenScore":737.990411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.548194240090844,"pubTatorScore":1.8669510776491742,"self":"https://pharos.nih.gov/idg/api/v1/targets(12935)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(12935)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(12935)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(12935)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(12935)/publications"},"_namespace":null},{"id":12936,"version":3,"created":1554958994000,"modified":1555041027000,"deprecated":false,"name":"Protein phosphatase 1 regulatory subunit 14C","accession":"Q8TAE6","gene":"PPP1R14C","description":"Inhibitor of the PP1 regulatory subunit PPP1CA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2292001804409292,"antibodyCount":79,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.982026,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.882450481969972,"pubTatorScore":1.6209659616763363,"self":"https://pharos.nih.gov/idg/api/v1/targets(12936)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(12936)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(12936)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12936)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12936)/publications"},"_namespace":null},{"id":12937,"version":3,"created":1554958997000,"modified":1555041028000,"deprecated":false,"name":"RNA-binding protein Musashi homolog 2","accession":"Q96DH6","gene":"MSI2","description":"RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6182656111065208,"antibodyCount":256,"monoclonalCount":110,"pubmedCount":null,"jensenScore":47.458399,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":39.57752037815439,"pubTatorScore":1.5622239905992839,"self":"https://pharos.nih.gov/idg/api/v1/targets(12937)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(12937)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(12937)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12937)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12937)/publications"},"_namespace":null},{"id":12938,"version":2,"created":1554959003000,"modified":1554959012000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily G member 3","accession":"Q8TAE7","gene":"KCNG3","description":"Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-0.37193573698733984,"antibodyCount":111,"monoclonalCount":21,"pubmedCount":null,"jensenScore":2.615926,"patentCount":1909,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.245906481211627,"pubTatorScore":1.1003053615859875,"self":"https://pharos.nih.gov/idg/api/v1/targets(12938)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(12938)/properties"},"_links":{"count":619,"href":"https://pharos.nih.gov/idg/api/v1/targets(12938)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12938)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12938)/publications"},"_namespace":null},{"id":12939,"version":3,"created":1554959013000,"modified":1555041029000,"deprecated":false,"name":"Growth arrest and DNA damage-inducible proteins-interacting protein 1","accession":"Q8TAE8","gene":"GADD45GIP1","description":"Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.279894966114215,"antibodyCount":112,"monoclonalCount":3,"pubmedCount":null,"jensenScore":24.141042,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":33.77070255030277,"pubTatorScore":1.1502445916302757,"self":"https://pharos.nih.gov/idg/api/v1/targets(12939)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(12939)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(12939)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(12939)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12939)/publications"},"_namespace":null},{"id":12940,"version":3,"created":1554959017000,"modified":1555041031000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 4 regulatory subunit 3A","accession":"Q6IN85","gene":"PPP4R3A","description":"Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0938939661134812,"antibodyCount":63,"monoclonalCount":3,"pubmedCount":null,"jensenScore":14.507817,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":0.0,"pubTatorScore":0.40067801167776634,"self":"https://pharos.nih.gov/idg/api/v1/targets(12940)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(12940)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(12940)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(12940)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(12940)/publications"},"_namespace":null},{"id":12941,"version":3,"created":1554959021000,"modified":1555041032000,"deprecated":false,"name":"rRNA methyltransferase 1, mitochondrial","accession":"Q6IN84","gene":"MRM1","description":"S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6183386839310958,"antibodyCount":98,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.007857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":31.33211661821935,"pubTatorScore":0.5632832346232435,"self":"https://pharos.nih.gov/idg/api/v1/targets(12941)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(12941)/properties"},"_links":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(12941)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(12941)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12941)/publications"},"_namespace":null},{"id":12942,"version":3,"created":1554959022000,"modified":1555041033000,"deprecated":false,"name":"Monocyte differentiation antigen CD14","accession":"P08571","gene":"CD14","description":"Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9951105451427549,"antibodyCount":2307,"monoclonalCount":1903,"pubmedCount":null,"jensenScore":109.594917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":43.56518732769636,"pubTatorScore":3.4700820056019266,"self":"https://pharos.nih.gov/idg/api/v1/targets(12942)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12942)/properties"},"_links":{"count":1608,"href":"https://pharos.nih.gov/idg/api/v1/targets(12942)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(12942)/synonyms"},"_publications":{"count":699,"href":"https://pharos.nih.gov/idg/api/v1/targets(12942)/publications"},"_namespace":null},{"id":12943,"version":3,"created":1554959032000,"modified":1555041037000,"deprecated":false,"name":"Cytochrome c1, heme protein, mitochondrial","accession":"P08574","gene":"CYC1","description":"This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7668642267073738,"antibodyCount":299,"monoclonalCount":6,"pubmedCount":null,"jensenScore":54.254053,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.090076396227886,"pubTatorScore":1.5156750820285743,"self":"https://pharos.nih.gov/idg/api/v1/targets(12943)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(12943)/properties"},"_links":{"count":1198,"href":"https://pharos.nih.gov/idg/api/v1/targets(12943)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12943)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(12943)/publications"},"_namespace":null},{"id":12944,"version":3,"created":1554959037000,"modified":1555041038000,"deprecated":false,"name":"Receptor-type tyrosine-protein phosphatase C","accession":"P08575","gene":"PTPRC","description":"Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.6929106349513843,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4642.970468,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":50.73101266704747,"pubTatorScore":3.40822044689886,"self":"https://pharos.nih.gov/idg/api/v1/targets(12944)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(12944)/properties"},"_links":{"count":1392,"href":"https://pharos.nih.gov/idg/api/v1/targets(12944)/links"},"_synonyms":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(12944)/synonyms"},"_publications":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(12944)/publications"},"_namespace":null},{"id":12945,"version":3,"created":1554959064000,"modified":1555041041000,"deprecated":false,"name":"Collagen alpha-2(IV) chain","accession":"P08572","gene":"COL4A2","description":"Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.893391673321413,"antibodyCount":139,"monoclonalCount":3,"pubmedCount":null,"jensenScore":76.598617,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.17981936816983,"pubTatorScore":1.7598270542958294,"self":"https://pharos.nih.gov/idg/api/v1/targets(12945)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(12945)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(12945)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(12945)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(12945)/publications"},"_namespace":null},{"id":12946,"version":3,"created":1554959071000,"modified":1555041044000,"deprecated":false,"name":"U2 small nuclear ribonucleoprotein B''","accession":"P08579","gene":"SNRPB2","description":"Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5173158901126986,"antibodyCount":110,"monoclonalCount":37,"pubmedCount":null,"jensenScore":3.017539,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":37.27342653349029,"pubTatorScore":0.282981950165751,"self":"https://pharos.nih.gov/idg/api/v1/targets(12946)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(12946)/properties"},"_links":{"count":1141,"href":"https://pharos.nih.gov/idg/api/v1/targets(12946)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(12946)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(12946)/publications"},"_namespace":null},{"id":12947,"version":3,"created":1554959075000,"modified":1555041046000,"deprecated":false,"name":"Muscleblind-like protein 2","accession":"Q5VZF2","gene":"MBNL2","description":"Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3205771005288698,"antibodyCount":97,"monoclonalCount":20,"pubmedCount":null,"jensenScore":14.560996,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.92232084372365,"pubTatorScore":1.0946026898083123,"self":"https://pharos.nih.gov/idg/api/v1/targets(12947)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(12947)/properties"},"_links":{"count":993,"href":"https://pharos.nih.gov/idg/api/v1/targets(12947)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(12947)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(12947)/publications"},"_namespace":null},{"id":12948,"version":3,"created":1554959080000,"modified":1555041047000,"deprecated":false,"name":"Phosphoglycerate kinase 2","accession":"P07205","gene":"PGK2","description":"Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.8522136478219535,"antibodyCount":156,"monoclonalCount":1,"pubmedCount":null,"jensenScore":67.747442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.822432590265084,"pubTatorScore":1.4339030930959118,"self":"https://pharos.nih.gov/idg/api/v1/targets(12948)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(12948)/properties"},"_links":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(12948)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(12948)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12948)/publications"},"_namespace":null},{"id":12949,"version":2,"created":1554959082000,"modified":1554959086000,"deprecated":false,"name":"Glutathione S-transferase Mu 4","accession":"Q03013","gene":"GSTM4","description":"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2123339750156332,"antibodyCount":95,"monoclonalCount":12,"pubmedCount":null,"jensenScore":13.723233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.37085537976903,"pubTatorScore":1.3029354457663798,"self":"https://pharos.nih.gov/idg/api/v1/targets(12949)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(12949)/properties"},"_links":{"count":1043,"href":"https://pharos.nih.gov/idg/api/v1/targets(12949)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(12949)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(12949)/publications"},"_namespace":null},{"id":12950,"version":2,"created":1554959086000,"modified":1554959091000,"deprecated":false,"name":"Hematopoietically-expressed homeobox protein HHEX","accession":"Q03014","gene":"HHEX","description":"Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.0565500040333085,"antibodyCount":363,"monoclonalCount":182,"pubmedCount":null,"jensenScore":1150.691908,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.791976138447765,"pubTatorScore":2.706891787787393,"self":"https://pharos.nih.gov/idg/api/v1/targets(12950)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":510,"href":"https://pharos.nih.gov/idg/api/v1/targets(12950)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(12950)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(12950)/synonyms"},"_publications":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(12950)/publications"},"_namespace":null},{"id":12951,"version":2,"created":1554959092000,"modified":1554959092000,"deprecated":false,"name":"Putative elongin-A3 member C","accession":"A0A087WX78","gene":"ELOA3C","description":"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12951)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12951)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(12951)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12951)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12951)/publications"},"_namespace":null},{"id":12952,"version":2,"created":1554959092000,"modified":1554959094000,"deprecated":false,"name":"Bone morphogenetic protein 8B","accession":"P34820","gene":"BMP8B","description":"Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0989385554771753,"antibodyCount":199,"monoclonalCount":51,"pubmedCount":null,"jensenScore":120.121626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.49174909078086,"pubTatorScore":1.6893144098867405,"self":"https://pharos.nih.gov/idg/api/v1/targets(12952)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(12952)/properties"},"_links":{"count":756,"href":"https://pharos.nih.gov/idg/api/v1/targets(12952)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12952)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(12952)/publications"},"_namespace":null},{"id":12953,"version":2,"created":1554959095000,"modified":1554959099000,"deprecated":false,"name":"Zinc transporter 5","accession":"Q8TAD4","gene":"SLC30A5","description":"Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.3904563859253616,"antibodyCount":29,"monoclonalCount":12,"pubmedCount":null,"jensenScore":25.652702,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.6029286169185,"pubTatorScore":1.2289366839652587,"self":"https://pharos.nih.gov/idg/api/v1/targets(12953)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(12953)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(12953)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(12953)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12953)/publications"},"_namespace":null},{"id":12954,"version":2,"created":1554959100000,"modified":1554959104000,"deprecated":false,"name":"Carboxymethylenebutenolidase homolog","accession":"Q96DG6","gene":"CMBL","description":"Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9152829119522727,"antibodyCount":68,"monoclonalCount":32,"pubmedCount":null,"jensenScore":78.236699,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.923988775963526,"pubTatorScore":1.6563948398176842,"self":"https://pharos.nih.gov/idg/api/v1/targets(12954)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(12954)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(12954)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(12954)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(12954)/publications"},"_namespace":null},{"id":12955,"version":2,"created":1554959105000,"modified":1554959107000,"deprecated":false,"name":"Deleted in autism-related protein 1","accession":"Q9H7Y0","gene":"CXorf36","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.36974580629626314,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.022861,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.5241177988362924,"self":"https://pharos.nih.gov/idg/api/v1/targets(12955)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(12955)/properties"},"_links":{"count":799,"href":"https://pharos.nih.gov/idg/api/v1/targets(12955)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12955)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12955)/publications"},"_namespace":null},{"id":12956,"version":2,"created":1554959108000,"modified":1554959111000,"deprecated":false,"name":"Overexpressed in colon carcinoma 1 protein","accession":"Q8TAD7","gene":"C12orf75","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6063860190352088,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.292879,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.3755052458928845,"self":"https://pharos.nih.gov/idg/api/v1/targets(12956)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(12956)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(12956)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(12956)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12956)/publications"},"_namespace":null},{"id":12957,"version":2,"created":1554959111000,"modified":1554959114000,"deprecated":false,"name":"Interleukin-17D","accession":"Q8TAD2","gene":"IL17D","description":"Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3025974972192813,"antibodyCount":327,"monoclonalCount":87,"pubmedCount":null,"jensenScore":17.369356,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.031971530826688,"pubTatorScore":0.9401121339429601,"self":"https://pharos.nih.gov/idg/api/v1/targets(12957)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(12957)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(12957)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12957)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12957)/publications"},"_namespace":null},{"id":12958,"version":2,"created":1554959115000,"modified":1554959119000,"deprecated":false,"name":"Zinc finger protein 10","accession":"P21506","gene":"ZNF10","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.7397982954993455,"antibodyCount":109,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.127832,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.608074876713513,"pubTatorScore":0.5919915596274158,"self":"https://pharos.nih.gov/idg/api/v1/targets(12958)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(12958)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(12958)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12958)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12958)/publications"},"_namespace":null},{"id":12959,"version":3,"created":1554959119000,"modified":1555041048000,"deprecated":false,"name":"Complement C1s subcomponent","accession":"P09871","gene":"C1S","description":"C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.000286728989034,"antibodyCount":305,"monoclonalCount":103,"pubmedCount":null,"jensenScore":964.085604,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.27713293480461,"pubTatorScore":2.6846200856462783,"self":"https://pharos.nih.gov/idg/api/v1/targets(12959)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":343,"href":"https://pharos.nih.gov/idg/api/v1/targets(12959)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(12959)/links"},"_synonyms":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(12959)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12959)/publications"},"_namespace":null},{"id":12960,"version":3,"created":1554959154000,"modified":1555041050000,"deprecated":false,"name":"Smad nuclear-interacting protein 1","accession":"Q8TAD8","gene":"SNIP1","description":"Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1485953003518905,"antibodyCount":148,"monoclonalCount":3,"pubmedCount":null,"jensenScore":16.605336,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":42,"knowledgeAvailability":33.750894811005686,"pubTatorScore":1.1283761315799932,"self":"https://pharos.nih.gov/idg/api/v1/targets(12960)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(12960)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(12960)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12960)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(12960)/publications"},"_namespace":null},{"id":12961,"version":3,"created":1554959158000,"modified":1555041052000,"deprecated":false,"name":"Ferrochelatase, mitochondrial","accession":"P22830","gene":"FECH","description":"Catalyzes the ferrous insertion into protoporphyrin IX.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.737591629860592,"antibodyCount":136,"monoclonalCount":21,"pubmedCount":null,"jensenScore":528.225104,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":48.94744402240738,"pubTatorScore":2.666998733879474,"self":"https://pharos.nih.gov/idg/api/v1/targets(12961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":479,"href":"https://pharos.nih.gov/idg/api/v1/targets(12961)/properties"},"_links":{"count":1159,"href":"https://pharos.nih.gov/idg/api/v1/targets(12961)/links"},"_synonyms":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(12961)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12961)/publications"},"_namespace":null},{"id":12962,"version":4,"created":1554959164000,"modified":1555041053000,"deprecated":false,"name":"Poly [ADP-ribose] polymerase 1","accession":"P09874","gene":"PARP1","description":"Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.722780565105562,"antibodyCount":1453,"monoclonalCount":315,"pubmedCount":null,"jensenScore":4886.48665,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":61.83668138356356,"pubTatorScore":3.614837965053387,"self":"https://pharos.nih.gov/idg/api/v1/targets(12962)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1367,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/properties"},"_links":{"count":3579,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/links"},"_synonyms":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/synonyms"},"_publications":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(12962)/publications"},"_namespace":null},{"id":12963,"version":3,"created":1554959747000,"modified":1554959777000,"deprecated":false,"name":"Dipeptidyl peptidase 8","accession":"Q6V1X1","gene":"DPP8","description":"Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.9527461662211432,"antibodyCount":195,"monoclonalCount":28,"pubmedCount":null,"jensenScore":78.036339,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.73833346913245,"pubTatorScore":1.765100889550235,"self":"https://pharos.nih.gov/idg/api/v1/targets(12963)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(12963)/properties"},"_links":{"count":1388,"href":"https://pharos.nih.gov/idg/api/v1/targets(12963)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(12963)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(12963)/publications"},"_namespace":null},{"id":12964,"version":2,"created":1554959779000,"modified":1554959785000,"deprecated":false,"name":"Dystonin","accession":"Q03001","gene":"DST","description":"Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.732305085943059,"antibodyCount":127,"monoclonalCount":32,"pubmedCount":null,"jensenScore":505.956769,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.2222816064615,"pubTatorScore":2.709660576495959,"self":"https://pharos.nih.gov/idg/api/v1/targets(12964)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(12964)/properties"},"_links":{"count":1320,"href":"https://pharos.nih.gov/idg/api/v1/targets(12964)/links"},"_synonyms":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(12964)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12964)/publications"},"_namespace":null},{"id":12965,"version":2,"created":1554959787000,"modified":1554959787000,"deprecated":false,"name":"Putative metaphase chromosome protein 1","accession":"P0CW71","gene":"HSMCR30","description":"Required during early stages of DNA replication such as the G1/S transition phase and early S phase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12965)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12965)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12965)/links"},"_synonyms":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12965)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12965)/publications"},"_namespace":null},{"id":12966,"version":3,"created":1554959787000,"modified":1555041061000,"deprecated":false,"name":"Zinc finger matrin-type protein 4","accession":"Q9H898","gene":"ZMAT4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2612628652095641,"antibodyCount":112,"monoclonalCount":28,"pubmedCount":null,"jensenScore":1.825,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":25.85649984163546,"pubTatorScore":0.5199737400632898,"self":"https://pharos.nih.gov/idg/api/v1/targets(12966)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(12966)/properties"},"_links":{"count":662,"href":"https://pharos.nih.gov/idg/api/v1/targets(12966)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12966)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12966)/publications"},"_namespace":null},{"id":12967,"version":3,"created":1554959790000,"modified":1555041063000,"deprecated":false,"name":"Intraflagellar transport protein 22 homolog","accession":"Q9H7X7","gene":"IFT22","description":"Small GTPase-like component of the intraflagellar transport (IFT) complex B.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.19066512630043134,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.907052,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":29.841018898116264,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(12967)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(12967)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(12967)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(12967)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12967)/publications"},"_namespace":null},{"id":12968,"version":2,"created":1554959794000,"modified":1554959797000,"deprecated":false,"name":"Uncharacterized protein C1orf115","accession":"Q9H7X2","gene":"C1orf115","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.146128035678238,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.037037,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12968)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(12968)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(12968)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(12968)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12968)/publications"},"_namespace":null},{"id":12969,"version":2,"created":1554959798000,"modified":1554959801000,"deprecated":false,"name":"Tetratricopeptide repeat protein 12","accession":"Q9H892","gene":"TTC12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1448252667607999,"antibodyCount":52,"monoclonalCount":3,"pubmedCount":null,"jensenScore":14.527963,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.871318095656623,"pubTatorScore":0.8817649116735589,"self":"https://pharos.nih.gov/idg/api/v1/targets(12969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(12969)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(12969)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12969)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12969)/publications"},"_namespace":null},{"id":12970,"version":3,"created":1554959802000,"modified":1555041064000,"deprecated":false,"name":"Macrosialin","accession":"P34810","gene":"CD68","description":"Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.598134392800389,"antibodyCount":1290,"monoclonalCount":938,"pubmedCount":null,"jensenScore":3485.900809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":38.294197012333974,"pubTatorScore":3.349246576810923,"self":"https://pharos.nih.gov/idg/api/v1/targets(12970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/properties"},"_links":{"count":1210,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(12970)/publications"},"_namespace":null},{"id":12971,"version":2,"created":1554959807000,"modified":1554959809000,"deprecated":false,"name":"Zinc finger protein 696","accession":"Q9H7X3","gene":"ZNF696","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.071429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.78163227440952,"pubTatorScore":-1.041393119452924,"self":"https://pharos.nih.gov/idg/api/v1/targets(12971)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/properties"},"_links":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(12971)/publications"},"_namespace":null},{"id":12972,"version":2,"created":1554959810000,"modified":1554959812000,"deprecated":false,"name":"Lipase member I","accession":"Q6XZB0","gene":"LIPI","description":"Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7988638038782332,"antibodyCount":71,"monoclonalCount":2,"pubmedCount":null,"jensenScore":59.881929,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.955122028368866,"pubTatorScore":1.0236155097608528,"self":"https://pharos.nih.gov/idg/api/v1/targets(12972)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/properties"},"_links":{"count":705,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12972)/publications"},"_namespace":null},{"id":12973,"version":2,"created":1554959813000,"modified":1554959816000,"deprecated":false,"name":"N-alpha-acetyltransferase 60","accession":"Q9H7X0","gene":"NAA60","description":"N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.422627590107911,"antibodyCount":89,"monoclonalCount":3,"pubmedCount":null,"jensenScore":24.460451,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.796996159722195,"pubTatorScore":0.8101204340434858,"self":"https://pharos.nih.gov/idg/api/v1/targets(12973)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(12973)/publications"},"_namespace":null},{"id":12974,"version":3,"created":1554959816000,"modified":1554959856000,"deprecated":false,"name":"Protein kinase C delta type","accession":"Q05655","gene":"PRKCD","description":"Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.1845245287794928,"antibodyCount":804,"monoclonalCount":140,"pubmedCount":null,"jensenScore":141.432359,"patentCount":7423,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":58.511156890794105,"pubTatorScore":3.2951110931035186,"self":"https://pharos.nih.gov/idg/api/v1/targets(12974)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1180,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/properties"},"_links":{"count":1730,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/synonyms"},"_publications":{"count":579,"href":"https://pharos.nih.gov/idg/api/v1/targets(12974)/publications"},"_namespace":null},{"id":12975,"version":2,"created":1554959859000,"modified":1554959860000,"deprecated":false,"name":"Testis-expressed protein 49","accession":"A0A1B0GTD5","gene":"TEX49","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12975)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/properties"},"_links":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(12975)/publications"},"_namespace":null},{"id":12976,"version":3,"created":1554959860000,"modified":1555041066000,"deprecated":false,"name":"Rieske domain-containing protein","accession":"Q8TAC1","gene":"RFESD","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":122,"monoclonalCount":15,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":23.40072982742963,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12976)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12976)/publications"},"_namespace":null},{"id":12977,"version":3,"created":1554959862000,"modified":1555041067000,"deprecated":false,"name":"Josephin-2","accession":"Q8TAC2","gene":"JOSD2","description":"Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.03476210770686023,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.433824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":25.88223378732587,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(12977)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(12977)/properties"},"_links":{"count":777,"href":"https://pharos.nih.gov/idg/api/v1/targets(12977)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(12977)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(12977)/publications"},"_namespace":null},{"id":12978,"version":3,"created":1554959865000,"modified":1555041068000,"deprecated":false,"name":"DNA polymerase alpha catalytic subunit","accession":"P09884","gene":"POLA1","description":"Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.408087676255005,"antibodyCount":129,"monoclonalCount":27,"pubmedCount":null,"jensenScore":246.516322,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":46.89897327286124,"pubTatorScore":3.0635949187617673,"self":"https://pharos.nih.gov/idg/api/v1/targets(12978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":504,"href":"https://pharos.nih.gov/idg/api/v1/targets(12978)/properties"},"_links":{"count":1096,"href":"https://pharos.nih.gov/idg/api/v1/targets(12978)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(12978)/synonyms"},"_publications":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12978)/publications"},"_namespace":null},{"id":12979,"version":3,"created":1554959884000,"modified":1555041070000,"deprecated":false,"name":"Protein DGCR14","accession":"Q96DF8","gene":"ESS2","description":"May be involved in pre-mRNA splicing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.510245363551372,"antibodyCount":86,"monoclonalCount":13,"pubmedCount":null,"jensenScore":288.090193,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":0.0,"pubTatorScore":2.0198890622850585,"self":"https://pharos.nih.gov/idg/api/v1/targets(12979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(12979)/properties"},"_links":{"count":1004,"href":"https://pharos.nih.gov/idg/api/v1/targets(12979)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12979)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(12979)/publications"},"_namespace":null},{"id":12980,"version":2,"created":1554959889000,"modified":1554959892000,"deprecated":false,"name":"Secretory carrier-associated membrane protein 5","accession":"Q8TAC9","gene":"SCAMP5","description":"Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7047223355413473,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.117296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.226158966149164,"pubTatorScore":0.5452482166960668,"self":"https://pharos.nih.gov/idg/api/v1/targets(12980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(12980)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(12980)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(12980)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(12980)/publications"},"_namespace":null},{"id":12981,"version":3,"created":1554959893000,"modified":1555041071000,"deprecated":false,"name":"Vitamin K-dependent protein S","accession":"P07225","gene":"PROS1","description":"Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3638934070216133,"antibodyCount":268,"monoclonalCount":55,"pubmedCount":null,"jensenScore":2143.896465,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.459269468453115,"pubTatorScore":2.224933754559775,"self":"https://pharos.nih.gov/idg/api/v1/targets(12981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":605,"href":"https://pharos.nih.gov/idg/api/v1/targets(12981)/properties"},"_links":{"count":1230,"href":"https://pharos.nih.gov/idg/api/v1/targets(12981)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(12981)/synonyms"},"_publications":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(12981)/publications"},"_namespace":null},{"id":12982,"version":3,"created":1554959901000,"modified":1555041073000,"deprecated":false,"name":"Beta-defensin 121","accession":"Q5J5C9","gene":"DEFB121","description":"Has antibacterial activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":7.462754391325892,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(12982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(12982)/properties"},"_links":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(12982)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(12982)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(12982)/publications"},"_namespace":null},{"id":12983,"version":2,"created":1554959901000,"modified":1554959903000,"deprecated":false,"name":"Actin-like protein 10","accession":"Q5JWF8","gene":"ACTL10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.915669099442697,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(12983)/properties"},"_links":{"count":690,"href":"https://pharos.nih.gov/idg/api/v1/targets(12983)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(12983)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(12983)/publications"},"_namespace":null},{"id":12984,"version":2,"created":1554959903000,"modified":1554959907000,"deprecated":false,"name":"TBC1 domain family member 31","accession":"Q96DN5","gene":"TBC1D31","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4771212590626073,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.7997008073063,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(12984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(12984)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(12984)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(12984)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(12984)/publications"},"_namespace":null},{"id":12985,"version":3,"created":1554959908000,"modified":1555041075000,"deprecated":false,"name":"Cyclin-dependent kinases regulatory subunit 2","accession":"P33552","gene":"CKS2","description":"Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4316321020565799,"antibodyCount":172,"monoclonalCount":45,"pubmedCount":null,"jensenScore":29.139981,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.74656456727315,"pubTatorScore":1.488843710018678,"self":"https://pharos.nih.gov/idg/api/v1/targets(12985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(12985)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(12985)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(12985)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(12985)/publications"},"_namespace":null},{"id":12986,"version":3,"created":1554959913000,"modified":1555041076000,"deprecated":false,"name":"GA-binding protein subunit beta-2","accession":"Q8TAK5","gene":"GABPB2","description":"May function as transcription factor capable of interacting with purine rich repeats (GA repeats).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.05191780105782,"antibodyCount":198,"monoclonalCount":31,"pubmedCount":null,"jensenScore":0.910715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.42459943190502,"pubTatorScore":-0.0943325387244521,"self":"https://pharos.nih.gov/idg/api/v1/targets(12986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(12986)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(12986)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(12986)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(12986)/publications"},"_namespace":null},{"id":12987,"version":3,"created":1554959917000,"modified":1555041077000,"deprecated":false,"name":"UBX domain-containing protein 1","accession":"Q04323","gene":"UBXN1","description":"Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7749222744628521,"antibodyCount":100,"monoclonalCount":5,"pubmedCount":null,"jensenScore":6.542939,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":38.604526714262015,"pubTatorScore":0.5860461247311751,"self":"https://pharos.nih.gov/idg/api/v1/targets(12987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(12987)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(12987)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(12987)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(12987)/publications"},"_namespace":null},{"id":12988,"version":2,"created":1554959921000,"modified":1554959925000,"deprecated":false,"name":"Methyl-CpG-binding domain protein 6","accession":"Q96DN6","gene":"MBD6","description":"Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5622928687994195,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.573132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.462355151427566,"pubTatorScore":0.5207018696737474,"self":"https://pharos.nih.gov/idg/api/v1/targets(12988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(12988)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(12988)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12988)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(12988)/publications"},"_namespace":null},{"id":12989,"version":2,"created":1554959925000,"modified":1554959928000,"deprecated":false,"name":"Oligodendrocyte transcription factor 1","accession":"Q8TAK6","gene":"OLIG1","description":"Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.83325441935763,"antibodyCount":240,"monoclonalCount":36,"pubmedCount":null,"jensenScore":65.286831,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.738160034325762,"pubTatorScore":1.6239046940182886,"self":"https://pharos.nih.gov/idg/api/v1/targets(12989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(12989)/properties"},"_links":{"count":694,"href":"https://pharos.nih.gov/idg/api/v1/targets(12989)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(12989)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(12989)/publications"},"_namespace":null},{"id":12990,"version":2,"created":1554959929000,"modified":1554959934000,"deprecated":false,"name":"Lymphocyte function-associated antigen 3","accession":"P19256","gene":"CD58","description":"Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6390640567644628,"antibodyCount":611,"monoclonalCount":441,"pubmedCount":null,"jensenScore":418.938995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.72004560417918,"pubTatorScore":2.5210698705675707,"self":"https://pharos.nih.gov/idg/api/v1/targets(12990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(12990)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(12990)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(12990)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(12990)/publications"},"_namespace":null},{"id":12991,"version":2,"created":1554959935000,"modified":1554959939000,"deprecated":false,"name":"Endoplasmic reticulum resident protein 27","accession":"Q96DN0","gene":"ERP27","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4451839641294225,"antibodyCount":82,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.239593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.232638396386175,"pubTatorScore":0.6766936096248666,"self":"https://pharos.nih.gov/idg/api/v1/targets(12991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(12991)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(12991)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(12991)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(12991)/publications"},"_namespace":null},{"id":12992,"version":3,"created":1554959939000,"modified":1555041080000,"deprecated":false,"name":"von Willebrand factor C and EGF domain-containing protein","accession":"Q96DN2","gene":"VWCE","description":"May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9397866114470947,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.945275,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":55,"knowledgeAvailability":22.609789157225556,"pubTatorScore":0.9646530990615481,"self":"https://pharos.nih.gov/idg/api/v1/targets(12992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(12992)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(12992)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(12992)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12992)/publications"},"_namespace":null},{"id":12993,"version":2,"created":1554959943000,"modified":1554959945000,"deprecated":false,"name":"Tryptase beta-2","accession":"P20231","gene":"TPSAB1","description":"Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8052631565463026,"antibodyCount":66,"monoclonalCount":16,"pubmedCount":null,"jensenScore":113.002965,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.447940551845342,"pubTatorScore":1.8637192851863167,"self":"https://pharos.nih.gov/idg/api/v1/targets(12993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(12993)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(12993)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(12993)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(12993)/publications"},"_namespace":null},{"id":12994,"version":3,"created":1554959946000,"modified":1554960028000,"deprecated":false,"name":"Neutrophil collagenase","accession":"P22894","gene":"MMP8","description":"Can degrade fibrillar type I, II, and III collagens.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.409548291824461,"antibodyCount":483,"monoclonalCount":72,"pubmedCount":null,"jensenScore":2433.687109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.50124692758013,"pubTatorScore":2.7111143707719383,"self":"https://pharos.nih.gov/idg/api/v1/targets(12994)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(12994)/properties"},"_links":{"count":1773,"href":"https://pharos.nih.gov/idg/api/v1/targets(12994)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(12994)/synonyms"},"_publications":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(12994)/publications"},"_namespace":null},{"id":12995,"version":2,"created":1554960031000,"modified":1554960034000,"deprecated":false,"name":"Transmembrane protein 268","accession":"Q5VZI3","gene":"TMEM268","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":73,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(12995)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(12995)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(12995)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(12995)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(12995)/publications"},"_namespace":null},{"id":12996,"version":3,"created":1554960035000,"modified":1555041081000,"deprecated":false,"name":"Vitamin K-dependent protein Z","accession":"P22891","gene":"PROZ","description":"Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.261538463951197,"antibodyCount":89,"monoclonalCount":46,"pubmedCount":null,"jensenScore":16.960394,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":29,"knowledgeAvailability":26.784323800125605,"pubTatorScore":0.7744590072699528,"self":"https://pharos.nih.gov/idg/api/v1/targets(12996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(12996)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(12996)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(12996)/synonyms"},"_publications":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(12996)/publications"},"_namespace":null},{"id":12997,"version":2,"created":1554960039000,"modified":1554960042000,"deprecated":false,"name":"Macrophage mannose receptor 1","accession":"P22897","gene":"MRC1","description":"(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E (PubMed:18266465). Interacts with hepatitis B virus envelope protein (PubMed:19683778).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6924547590953583,"antibodyCount":489,"monoclonalCount":324,"pubmedCount":null,"jensenScore":419.276482,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.38056137793912,"pubTatorScore":2.135655510231058,"self":"https://pharos.nih.gov/idg/api/v1/targets(12997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(12997)/properties"},"_links":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(12997)/links"},"_synonyms":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(12997)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(12997)/publications"},"_namespace":null},{"id":12998,"version":3,"created":1554960043000,"modified":1555041085000,"deprecated":false,"name":"Tumor necrosis factor alpha-induced protein 3","accession":"P21580","gene":"TNFAIP3","description":"Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.456150398659471,"antibodyCount":309,"monoclonalCount":79,"pubmedCount":null,"jensenScore":259.201449,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":58.19766321808849,"pubTatorScore":2.4004604155702616,"self":"https://pharos.nih.gov/idg/api/v1/targets(12998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(12998)/properties"},"_links":{"count":1307,"href":"https://pharos.nih.gov/idg/api/v1/targets(12998)/links"},"_synonyms":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(12998)/synonyms"},"_publications":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(12998)/publications"},"_namespace":null},{"id":12999,"version":2,"created":1554960051000,"modified":1554960054000,"deprecated":false,"name":"Uncharacterized protein C18orf8","accession":"Q96DM3","gene":"RMC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3631779028471202,"antibodyCount":121,"monoclonalCount":9,"pubmedCount":null,"jensenScore":0.278571,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.8751287185623398,"self":"https://pharos.nih.gov/idg/api/v1/targets(12999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(12999)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(12999)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(12999)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(12999)/publications"},"_namespace":null},{"id":13000,"version":2,"created":1554960055000,"modified":1554960057000,"deprecated":false,"name":"PiggyBac transposable element-derived protein 4","accession":"Q96DM1","gene":"PGBD4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.1760912590556813,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.055556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.546819704268671,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(13000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(13000)/properties"},"_links":{"count":746,"href":"https://pharos.nih.gov/idg/api/v1/targets(13000)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(13000)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(13000)/publications"},"_namespace":null}]}