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Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-2.536072686689834,"antibodyCount":525,"monoclonalCount":223,"pubmedCount":null,"jensenScore":345.883848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":45.91291286401494,"pubTatorScore":2.3733098901859435,"self":"https://pharos.nih.gov/idg/api/v1/targets(11033)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(11033)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(11033)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(11033)/synonyms"},"_publications":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(11033)/publications"},"_namespace":null},{"id":11034,"version":2,"created":1554935298000,"modified":1554935299000,"deprecated":false,"name":"Ret finger protein-like 4A-like protein 1","accession":"F8VTS6","gene":"RFPL4AL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.469514337957297,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11034)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(11034)/properties"},"_links":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(11034)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(11034)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(11034)/publications"},"_namespace":null},{"id":11035,"version":3,"created":1554935299000,"modified":1555039797000,"deprecated":false,"name":"Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6","accession":"Q6NYC1","gene":"JMJD6","description":"Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.8349367913583756,"antibodyCount":330,"monoclonalCount":43,"pubmedCount":null,"jensenScore":671.451191,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":62,"knowledgeAvailability":39.74143544938803,"pubTatorScore":2.007494157893106,"self":"https://pharos.nih.gov/idg/api/v1/targets(11035)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(11035)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(11035)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11035)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(11035)/publications"},"_namespace":null},{"id":11036,"version":2,"created":1554935304000,"modified":1554935304000,"deprecated":false,"name":"Putative testis-specific Y-encoded-like protein 3","accession":"Q9H489","gene":"TSPY26P","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.520043520520222,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11036)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(11036)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(11036)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(11036)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(11036)/publications"},"_namespace":null},{"id":11037,"version":2,"created":1554935304000,"modified":1554935306000,"deprecated":false,"name":"GDP-fucose protein O-fucosyltransferase 1","accession":"Q9H488","gene":"POFUT1","description":"Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5309919812016888,"antibodyCount":157,"monoclonalCount":7,"pubmedCount":null,"jensenScore":37.539966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.3236943896327,"pubTatorScore":1.2760746729984282,"self":"https://pharos.nih.gov/idg/api/v1/targets(11037)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(11037)/publications"},"_namespace":null},{"id":11038,"version":2,"created":1554935307000,"modified":1554935321000,"deprecated":false,"name":"Alcohol dehydrogenase class-3","accession":"P11766","gene":"ADH5","description":"Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.37411469945803,"antibodyCount":283,"monoclonalCount":27,"pubmedCount":null,"jensenScore":239.487009,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.84870111136859,"pubTatorScore":2.3292314364027606,"self":"https://pharos.nih.gov/idg/api/v1/targets(11038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/properties"},"_links":{"count":1098,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(11038)/publications"},"_namespace":null},{"id":11039,"version":3,"created":1554935323000,"modified":1555039798000,"deprecated":false,"name":"Leucine-rich repeat neuronal protein 3","accession":"Q9H3W5","gene":"LRRN3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.944913309634738,"antibodyCount":146,"monoclonalCount":1,"pubmedCount":null,"jensenScore":9.903764,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":28.824031709663224,"pubTatorScore":0.7063518481650557,"self":"https://pharos.nih.gov/idg/api/v1/targets(11039)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(11039)/publications"},"_namespace":null},{"id":11040,"version":3,"created":1554935326000,"modified":1555039799000,"deprecated":false,"name":"Piwi-like protein 4","accession":"Q7Z3Z4","gene":"PIWIL4","description":"Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7580104861779606,"antibodyCount":177,"monoclonalCount":39,"pubmedCount":null,"jensenScore":535.105379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.589640396121805,"pubTatorScore":1.1549501943951999,"self":"https://pharos.nih.gov/idg/api/v1/targets(11040)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(11040)/publications"},"_namespace":null},{"id":11041,"version":2,"created":1554935331000,"modified":1554935333000,"deprecated":false,"name":"Piwi-like protein 3","accession":"Q7Z3Z3","gene":"PIWIL3","description":"May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7842973897796739,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.457948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.763982616546821,"pubTatorScore":0.6565506678973989,"self":"https://pharos.nih.gov/idg/api/v1/targets(11041)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/properties"},"_links":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(11041)/publications"},"_namespace":null},{"id":11042,"version":3,"created":1554935333000,"modified":1555039801000,"deprecated":false,"name":"Upstream stimulatory factor 1","accession":"P22415","gene":"USF1","description":"Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.763215935918238,"antibodyCount":246,"monoclonalCount":53,"pubmedCount":null,"jensenScore":593.805053,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.670058599636974,"pubTatorScore":2.4983587895086887,"self":"https://pharos.nih.gov/idg/api/v1/targets(11042)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":525,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/synonyms"},"_publications":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(11042)/publications"},"_namespace":null},{"id":11043,"version":2,"created":1554935339000,"modified":1554935340000,"deprecated":false,"name":"Complement factor H-related protein 4","accession":"Q92496","gene":"CFHR4","description":"Involved in complement regulation. 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Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.9276397960365115,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7391.79651,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":11.067262120471062,"pubTatorScore":1.5496162150172803,"self":"https://pharos.nih.gov/idg/api/v1/targets(11044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(11044)/properties"},"_links":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(11044)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(11044)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(11044)/publications"},"_namespace":null},{"id":11045,"version":3,"created":1554935342000,"modified":1555039803000,"deprecated":false,"name":"Collagen alpha-2(I) chain","accession":"P08123","gene":"COL1A2","description":"Type I collagen is a member of group I collagen (fibrillar forming collagen).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.642843007729152,"antibodyCount":258,"monoclonalCount":32,"pubmedCount":null,"jensenScore":404.011384,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":52.6725116407384,"pubTatorScore":3.10281007826347,"self":"https://pharos.nih.gov/idg/api/v1/targets(11045)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(11045)/properties"},"_links":{"count":1438,"href":"https://pharos.nih.gov/idg/api/v1/targets(11045)/links"},"_synonyms":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(11045)/synonyms"},"_publications":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(11045)/publications"},"_namespace":null},{"id":11046,"version":3,"created":1554935352000,"modified":1555039806000,"deprecated":false,"name":"ATP-dependent RNA helicase DDX1","accession":"Q92499","gene":"DDX1","description":"(Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication (PubMed:15567440, PubMed:20573827). 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Acts as a negative regulator of Toll-like receptor signaling (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8169773900733341,"antibodyCount":79,"monoclonalCount":34,"pubmedCount":null,"jensenScore":8.602432,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.497490732222253,"pubTatorScore":0.464886847936303,"self":"https://pharos.nih.gov/idg/api/v1/targets(11069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(11069)/properties"},"_links":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(11069)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(11069)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(11069)/publications"},"_namespace":null},{"id":11070,"version":2,"created":1554935762000,"modified":1554935765000,"deprecated":false,"name":"Acid sphingomyelinase-like phosphodiesterase 3a","accession":"Q92484","gene":"SMPDL3A","description":"Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.535715963905387,"antibodyCount":95,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.980254,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.55728784794782,"pubTatorScore":0.6197886888012714,"self":"https://pharos.nih.gov/idg/api/v1/targets(11070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(11070)/publications"},"_namespace":null},{"id":11071,"version":2,"created":1554935765000,"modified":1554935766000,"deprecated":false,"name":"Keratin-associated protein 19-7","accession":"Q3SYF9","gene":"KRTAP19-7","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.888999586223538,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/properties"},"_links":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(11071)/publications"},"_namespace":null},{"id":11072,"version":2,"created":1554935766000,"modified":1554935768000,"deprecated":false,"name":"Keratin, type I cytoskeletal 26","accession":"Q7Z3Y9","gene":"KRT26","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5335723812091486,"antibodyCount":82,"monoclonalCount":7,"pubmedCount":null,"jensenScore":34.996427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.480671460628079,"pubTatorScore":0.9785391755018805,"self":"https://pharos.nih.gov/idg/api/v1/targets(11072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/properties"},"_links":{"count":354,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(11072)/publications"},"_namespace":null},{"id":11073,"version":2,"created":1554935769000,"modified":1554935771000,"deprecated":false,"name":"Paired box protein Pax-7","accession":"P23759","gene":"PAX7","description":"Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.7070288181384083,"antibodyCount":418,"monoclonalCount":166,"pubmedCount":null,"jensenScore":468.710886,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.93636235544281,"pubTatorScore":2.3193383894862,"self":"https://pharos.nih.gov/idg/api/v1/targets(11073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/properties"},"_links":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(11073)/publications"},"_namespace":null},{"id":11074,"version":2,"created":1554935772000,"modified":1554935774000,"deprecated":false,"name":"Keratin, type I cytoskeletal 27","accession":"Q7Z3Y8","gene":"KRT27","description":"Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.040617852614420934,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.920119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.396278965668543,"pubTatorScore":1.6123464714821578,"self":"https://pharos.nih.gov/idg/api/v1/targets(11074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(11074)/publications"},"_namespace":null},{"id":11075,"version":3,"created":1554935774000,"modified":1555039830000,"deprecated":false,"name":"Apoptosis regulator BAX","accession":"Q07812","gene":"BAX","description":"Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.578336855192859,"antibodyCount":1395,"monoclonalCount":500,"pubmedCount":null,"jensenScore":248.409133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":59.788090856424276,"pubTatorScore":3.6575194966446265,"self":"https://pharos.nih.gov/idg/api/v1/targets(11075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1464,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/properties"},"_links":{"count":1989,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/links"},"_synonyms":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/synonyms"},"_publications":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(11075)/publications"},"_namespace":null},{"id":11076,"version":2,"created":1554935789000,"modified":1554935793000,"deprecated":false,"name":"Aquaporin-3","accession":"Q92482","gene":"AQP3","description":"Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6171709915741235,"antibodyCount":260,"monoclonalCount":0,"pubmedCount":null,"jensenScore":402.996969,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.96645543095002,"pubTatorScore":2.3056353223894535,"self":"https://pharos.nih.gov/idg/api/v1/targets(11076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":506,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/synonyms"},"_publications":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(11076)/publications"},"_namespace":null},{"id":11077,"version":3,"created":1554935794000,"modified":1555039835000,"deprecated":false,"name":"Rho-related GTP-binding protein RhoC","accession":"P08134","gene":"RHOC","description":"Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.3409523064232283,"antibodyCount":224,"monoclonalCount":73,"pubmedCount":null,"jensenScore":216.36824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":37.999616788164275,"pubTatorScore":2.3685847682518717,"self":"https://pharos.nih.gov/idg/api/v1/targets(11077)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/properties"},"_links":{"count":1168,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/synonyms"},"_publications":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(11077)/publications"},"_namespace":null},{"id":11078,"version":2,"created":1554935799000,"modified":1554935802000,"deprecated":false,"name":"Glycodelin","accession":"P09466","gene":"PAEP","description":"Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.851656518651632,"antibodyCount":237,"monoclonalCount":67,"pubmedCount":null,"jensenScore":716.873215,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.297641968052936,"pubTatorScore":2.947489278126487,"self":"https://pharos.nih.gov/idg/api/v1/targets(11078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/properties"},"_links":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(11078)/publications"},"_namespace":null},{"id":11079,"version":2,"created":1554935803000,"modified":1554935808000,"deprecated":false,"name":"Annexin A6","accession":"P08133","gene":"ANXA6","description":"May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.448933228551649,"antibodyCount":381,"monoclonalCount":39,"pubmedCount":null,"jensenScore":298.751732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.176387378208396,"pubTatorScore":2.3216207286467716,"self":"https://pharos.nih.gov/idg/api/v1/targets(11079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/properties"},"_links":{"count":1182,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(11079)/publications"},"_namespace":null},{"id":11080,"version":3,"created":1554935809000,"modified":1555039837000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 16","accession":"P08138","gene":"NGFR","description":"Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.062391848301761,"antibodyCount":881,"monoclonalCount":403,"pubmedCount":null,"jensenScore":1162.143121,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":47.33357900606395,"pubTatorScore":2.8523614760696523,"self":"https://pharos.nih.gov/idg/api/v1/targets(11080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":695,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/properties"},"_links":{"count":1233,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/synonyms"},"_publications":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(11080)/publications"},"_namespace":null},{"id":11081,"version":3,"created":1554935818000,"modified":1554935907000,"deprecated":false,"name":"Fructose-1,6-bisphosphatase 1","accession":"P09467","gene":"FBP1","description":"Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.0682371115188225,"antibodyCount":202,"monoclonalCount":11,"pubmedCount":null,"jensenScore":111.802414,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.892380901919175,"pubTatorScore":2.056337478960672,"self":"https://pharos.nih.gov/idg/api/v1/targets(11081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/properties"},"_links":{"count":1304,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/links"},"_synonyms":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(11081)/publications"},"_namespace":null},{"id":11082,"version":2,"created":1554935909000,"modified":1554935914000,"deprecated":false,"name":"Death effector domain-containing protein","accession":"O75618","gene":"DEDD","description":"A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.38138193892328,"antibodyCount":166,"monoclonalCount":22,"pubmedCount":null,"jensenScore":233.441752,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.96125691801591,"pubTatorScore":1.0407341510299568,"self":"https://pharos.nih.gov/idg/api/v1/targets(11082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(11082)/publications"},"_namespace":null},{"id":11083,"version":3,"created":1554935915000,"modified":1555039839000,"deprecated":false,"name":"High mobility group protein B1","accession":"P09429","gene":"HMGB1","description":"In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). 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Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.062368784948053,"antibodyCount":58,"monoclonalCount":8,"pubmedCount":null,"jensenScore":118.064993,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.813862408409946,"pubTatorScore":1.7126959313291779,"self":"https://pharos.nih.gov/idg/api/v1/targets(11349)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/links"},"_synonyms":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(11349)/publications"},"_namespace":null},{"id":11350,"version":3,"created":1554939194000,"modified":1555040017000,"deprecated":false,"name":"Radial spoke head 10 homolog B2","accession":"B2RC85","gene":"RSPH10B2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":8.404918171859942,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11350)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/properties"},"_links":{"count":577,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(11350)/publications"},"_namespace":null},{"id":11351,"version":3,"created":1554939196000,"modified":1555040019000,"deprecated":false,"name":"Receptor-type tyrosine-protein phosphatase delta","accession":"P23468","gene":"PTPRD","description":"Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. 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Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). 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Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.551954124167235,"antibodyCount":432,"monoclonalCount":89,"pubmedCount":null,"jensenScore":357.014979,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":51.94818116841506,"pubTatorScore":2.3662490327617243,"self":"https://pharos.nih.gov/idg/api/v1/targets(11354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":662,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/synonyms"},"_publications":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(11354)/publications"},"_namespace":null},{"id":11355,"version":2,"created":1554939218000,"modified":1554939221000,"deprecated":false,"name":"Cartilage intermediate layer protein 1","accession":"O75339","gene":"CILP","description":"Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4899650490471519,"antibodyCount":120,"monoclonalCount":27,"pubmedCount":null,"jensenScore":33.654313,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.02423825766472,"pubTatorScore":1.527389451680619,"self":"https://pharos.nih.gov/idg/api/v1/targets(11355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(11355)/publications"},"_namespace":null},{"id":11356,"version":3,"created":1554939222000,"modified":1555040024000,"deprecated":false,"name":"Liprin-alpha-4","accession":"O75335","gene":"PPFIA4","description":"May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.126319643027829,"antibodyCount":31,"monoclonalCount":11,"pubmedCount":null,"jensenScore":1.07186,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.48968270508621,"pubTatorScore":-0.24303772296555518,"self":"https://pharos.nih.gov/idg/api/v1/targets(11356)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(11356)/publications"},"_namespace":null},{"id":11357,"version":2,"created":1554939226000,"modified":1554939234000,"deprecated":false,"name":"Transcriptional regulator ATRX","accession":"P46100","gene":"ATRX","description":"Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomers. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomers nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8527659229970244,"antibodyCount":248,"monoclonalCount":118,"pubmedCount":null,"jensenScore":705.859796,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.96409288592764,"pubTatorScore":2.4463639164349584,"self":"https://pharos.nih.gov/idg/api/v1/targets(11357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/properties"},"_links":{"count":1547,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/links"},"_synonyms":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/synonyms"},"_publications":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(11357)/publications"},"_namespace":null},{"id":11358,"version":2,"created":1554939236000,"modified":1554939237000,"deprecated":false,"name":"T-box transcription factor TBX10","accession":"O75333","gene":"TBX10","description":"Probable transcriptional regulator involved in developmental processes.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.8933191399946753,"antibodyCount":110,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.846197,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.92123634235105,"pubTatorScore":0.6299473426386697,"self":"https://pharos.nih.gov/idg/api/v1/targets(11358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/properties"},"_links":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(11358)/publications"},"_namespace":null},{"id":11359,"version":2,"created":1554939238000,"modified":1554939243000,"deprecated":false,"name":"Lon protease homolog, mitochondrial","accession":"P36776","gene":"LONP1","description":"ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2480461079976726,"antibodyCount":174,"monoclonalCount":38,"pubmedCount":null,"jensenScore":169.598442,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.482779411272936,"pubTatorScore":2.333431956025404,"self":"https://pharos.nih.gov/idg/api/v1/targets(11359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/properties"},"_links":{"count":1230,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/links"},"_synonyms":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(11359)/publications"},"_namespace":null},{"id":11360,"version":3,"created":1554939244000,"modified":1555040025000,"deprecated":false,"name":"Liprin-alpha-2","accession":"O75334","gene":"PPFIA2","description":"Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. 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Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9198842174686137,"antibodyCount":124,"monoclonalCount":7,"pubmedCount":null,"jensenScore":87.237174,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.1020590418601,"pubTatorScore":1.6947218286280274,"self":"https://pharos.nih.gov/idg/api/v1/targets(11361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/properties"},"_links":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(11361)/publications"},"_namespace":null},{"id":11362,"version":3,"created":1554939253000,"modified":1555040026000,"deprecated":false,"name":"Thrombospondin-2","accession":"P35442","gene":"THBS2","description":"Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3560777497979464,"antibodyCount":150,"monoclonalCount":32,"pubmedCount":null,"jensenScore":237.670691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":38.81499148879512,"pubTatorScore":2.114368455453351,"self":"https://pharos.nih.gov/idg/api/v1/targets(11362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/properties"},"_links":{"count":1095,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(11362)/publications"},"_namespace":null},{"id":11363,"version":3,"created":1554939258000,"modified":1555040028000,"deprecated":false,"name":"Hyaluronan mediated motility receptor","accession":"O75330","gene":"HMMR","description":"Receptor for hyaluronic acid (HA) (By similarity). 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Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. 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Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.1836128545976496,"antibodyCount":1818,"monoclonalCount":222,"pubmedCount":null,"jensenScore":0.0,"patentCount":50455,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":57.63199334862673,"pubTatorScore":2.9012400109443472,"self":"https://pharos.nih.gov/idg/api/v1/targets(11382)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/properties"},"_links":{"count":1653,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/links"},"_synonyms":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/synonyms"},"_publications":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(11382)/publications"},"_namespace":null},{"id":11383,"version":2,"created":1554939415000,"modified":1554939417000,"deprecated":false,"name":"RNA/RNP complex-1-interacting phosphatase","accession":"O75319","gene":"DUSP11","description":"Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. 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Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0669024866150023,"antibodyCount":173,"monoclonalCount":28,"pubmedCount":null,"jensenScore":11.629333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.638165954130336,"pubTatorScore":0.8749233095560187,"self":"https://pharos.nih.gov/idg/api/v1/targets(11384)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(11384)/publications"},"_namespace":null},{"id":11385,"version":2,"created":1554939422000,"modified":1554939423000,"deprecated":false,"name":"Protein FAM47A","accession":"Q5JRC9","gene":"FAM47A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.775078723404748,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11385)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/properties"},"_links":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(11385)/publications"},"_namespace":null},{"id":11386,"version":2,"created":1554939423000,"modified":1554939425000,"deprecated":false,"name":"Protein FAM98C","accession":"Q17RN3","gene":"FAM98C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.4471549913744,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11386)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(11386)/publications"},"_namespace":null},{"id":11387,"version":2,"created":1554939426000,"modified":1554939431000,"deprecated":false,"name":"Mannan-binding lectin serine protease 1","accession":"P48740","gene":"MASP1","description":"Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.490402355367013,"antibodyCount":223,"monoclonalCount":32,"pubmedCount":null,"jensenScore":334.043653,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.81372405607422,"pubTatorScore":2.2180236972826624,"self":"https://pharos.nih.gov/idg/api/v1/targets(11387)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/links"},"_synonyms":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(11387)/publications"},"_namespace":null},{"id":11388,"version":3,"created":1554939432000,"modified":1555040042000,"deprecated":false,"name":"Glycine receptor subunit alpha-3","accession":"O75311","gene":"GLRA3","description":"Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.1193711364439842,"antibodyCount":82,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.876657,"patentCount":1064,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.929602600151817,"pubTatorScore":1.3439007122496063,"self":"https://pharos.nih.gov/idg/api/v1/targets(11388)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/properties"},"_links":{"count":640,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(11388)/publications"},"_namespace":null},{"id":11389,"version":2,"created":1554939438000,"modified":1554939442000,"deprecated":false,"name":"Zinc finger protein ZPR1","accession":"O75312","gene":"ZPR1","description":"Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4115291797652552,"antibodyCount":201,"monoclonalCount":57,"pubmedCount":null,"jensenScore":28.232085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.776792907751656,"pubTatorScore":1.2862218109929586,"self":"https://pharos.nih.gov/idg/api/v1/targets(11389)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(11389)/publications"},"_namespace":null},{"id":11390,"version":2,"created":1554939443000,"modified":1554939446000,"deprecated":false,"name":"C-C motif chemokine 3","accession":"P10147","gene":"CCL3","description":"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1622853317150885,"antibodyCount":677,"monoclonalCount":234,"pubmedCount":null,"jensenScore":1382.613702,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.922620472659503,"pubTatorScore":2.932079474157689,"self":"https://pharos.nih.gov/idg/api/v1/targets(11390)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":444,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/properties"},"_links":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/links"},"_synonyms":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/synonyms"},"_publications":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(11390)/publications"},"_namespace":null},{"id":11391,"version":2,"created":1554939447000,"modified":1554939449000,"deprecated":false,"name":"UDP-glucuronosyltransferase 2B11","accession":"O75310","gene":"UGT2B11","description":"UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.26857527440133455,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.792879,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.797353300897246,"pubTatorScore":0.7522924297123683,"self":"https://pharos.nih.gov/idg/api/v1/targets(11391)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/properties"},"_links":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(11391)/publications"},"_namespace":null},{"id":11392,"version":2,"created":1554939449000,"modified":1554939465000,"deprecated":false,"name":"Steroid hormone receptor ERR1","accession":"P11474","gene":"ESRRA","description":"Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.","idgFamily":"Nuclear Receptor","idgTDL":"Tchem","novelty":-2.134511670087567,"antibodyCount":356,"monoclonalCount":58,"pubmedCount":null,"jensenScore":156.694128,"patentCount":7551,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.59663101235177,"pubTatorScore":2.230409314470212,"self":"https://pharos.nih.gov/idg/api/v1/targets(11392)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(11392)/publications"},"_namespace":null},{"id":11393,"version":2,"created":1554939466000,"modified":1554939469000,"deprecated":false,"name":"Transmembrane protein 119","accession":"Q4V9L6","gene":"TMEM119","description":"Plays an important role in bone formation and normal bone mineralization. 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Essential for normal spermatogenesis and late testicular differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9867628604177555,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.843337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.341076392294397,"pubTatorScore":0.2792150792911802,"self":"https://pharos.nih.gov/idg/api/v1/targets(11393)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(11393)/publications"},"_namespace":null},{"id":11394,"version":3,"created":1554939470000,"modified":1554939537000,"deprecated":false,"name":"Vitamin D3 receptor","accession":"P11473","gene":"VDR","description":"Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.","idgFamily":"Nuclear Receptor","idgTDL":"Tclin","novelty":-3.6216566164252297,"antibodyCount":575,"monoclonalCount":123,"pubmedCount":null,"jensenScore":3805.660716,"patentCount":27459,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.87295175288682,"pubTatorScore":3.639271891994898,"self":"https://pharos.nih.gov/idg/api/v1/targets(11394)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2029,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/properties"},"_links":{"count":2368,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/links"},"_synonyms":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/synonyms"},"_publications":{"count":1688,"href":"https://pharos.nih.gov/idg/api/v1/targets(11394)/publications"},"_namespace":null},{"id":11395,"version":2,"created":1554939543000,"modified":1554939553000,"deprecated":false,"name":"Granzyme B","accession":"P10144","gene":"GZMB","description":"This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. 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Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.7568229993106317,"antibodyCount":722,"monoclonalCount":183,"pubmedCount":null,"jensenScore":579.453422,"patentCount":17196,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.16771641844534,"pubTatorScore":2.261484221649041,"self":"https://pharos.nih.gov/idg/api/v1/targets(11401)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/properties"},"_links":{"count":1603,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/links"},"_synonyms":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/synonyms"},"_publications":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(11401)/publications"},"_namespace":null},{"id":11402,"version":2,"created":1554940056000,"modified":1554940063000,"deprecated":false,"name":"Isocitrate dehydrogenase [NADP], mitochondrial","accession":"P48735","gene":"IDH2","description":"Plays a role in intermediary metabolism and energy production. 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Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5374191876313887,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":34.314108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.765155366873365,"pubTatorScore":1.3418739585724149,"self":"https://pharos.nih.gov/idg/api/v1/targets(11436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(11436)/publications"},"_namespace":null},{"id":11437,"version":3,"created":1554940181000,"modified":1555040069000,"deprecated":false,"name":"Presenilins-associated rhomboid-like protein, mitochondrial","accession":"Q9H300","gene":"PARL","description":"Required for the control of apoptosis during postnatal growth. 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Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. 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Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. 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Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8341784133749252,"antibodyCount":140,"monoclonalCount":4,"pubmedCount":null,"jensenScore":6.758973,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.977890279931795,"pubTatorScore":0.8315193831048101,"self":"https://pharos.nih.gov/idg/api/v1/targets(11533)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(11533)/publications"},"_namespace":null},{"id":11534,"version":2,"created":1554943460000,"modified":1554943463000,"deprecated":false,"name":"Kelch-like protein 38","accession":"Q2WGJ6","gene":"KLHL38","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.835988574408448,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11534)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/properties"},"_links":{"count":754,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(11534)/publications"},"_namespace":null},{"id":11535,"version":2,"created":1554943463000,"modified":1554943464000,"deprecated":false,"name":"Transmembrane protein 249","accession":"Q2WGJ8","gene":"TMEM249","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.425004290203958,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(11535)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/properties"},"_links":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(11535)/publications"},"_namespace":null},{"id":11536,"version":2,"created":1554943464000,"modified":1554943471000,"deprecated":false,"name":"Transient receptor potential cation channel subfamily V member 6","accession":"Q9H1D0","gene":"TRPV6","description":"Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.3829891688009153,"antibodyCount":126,"monoclonalCount":0,"pubmedCount":null,"jensenScore":247.09128,"patentCount":25242,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.01981007461905,"pubTatorScore":2.265833975201869,"self":"https://pharos.nih.gov/idg/api/v1/targets(11536)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/properties"},"_links":{"count":962,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(11536)/publications"},"_namespace":null},{"id":11537,"version":3,"created":1554943472000,"modified":1555040132000,"deprecated":false,"name":"5-hydroxytryptamine receptor 3D","accession":"Q70Z44","gene":"HTR3D","description":"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. 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Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6519803458833617,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":43.333664,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.596281786239125,"pubTatorScore":1.4769276175544086,"self":"https://pharos.nih.gov/idg/api/v1/targets(11540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":411,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(11540)/publications"},"_namespace":null},{"id":11541,"version":2,"created":1554943494000,"modified":1554943497000,"deprecated":false,"name":"Talin rod domain-containing protein 1","accession":"Q9H1K6","gene":"TLNRD1","description":"Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3357921033708414,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.481944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.425968786559088,"self":"https://pharos.nih.gov/idg/api/v1/targets(11541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/properties"},"_links":{"count":767,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(11541)/publications"},"_namespace":null},{"id":11542,"version":2,"created":1554943497000,"modified":1554943502000,"deprecated":false,"name":"Mitochondrial glutamate carrier 2","accession":"Q9H1K4","gene":"SLC25A18","description":"Involved in the transport of glutamate across the inner mitochondrial membrane. 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First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2583946389688583,"antibodyCount":167,"monoclonalCount":49,"pubmedCount":null,"jensenScore":167.285193,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.40015462524036,"pubTatorScore":1.7933912019647085,"self":"https://pharos.nih.gov/idg/api/v1/targets(11543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/properties"},"_links":{"count":1209,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(11543)/publications"},"_namespace":null},{"id":11544,"version":3,"created":1554943507000,"modified":1555040133000,"deprecated":false,"name":"Rabenosyn-5","accession":"Q9H1K0","gene":"RBSN","description":"Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2447404495576526,"antibodyCount":121,"monoclonalCount":5,"pubmedCount":null,"jensenScore":148.413177,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":36.88789414900067,"pubTatorScore":1.0958587566115814,"self":"https://pharos.nih.gov/idg/api/v1/targets(11544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(11544)/publications"},"_namespace":null},{"id":11545,"version":4,"created":1554943513000,"modified":1555040135000,"deprecated":false,"name":"Tyrosine-protein kinase ITK/TSK","accession":"Q08881","gene":"ITK","description":"Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. 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Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). 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This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.2563491516796805,"antibodyCount":391,"monoclonalCount":146,"pubmedCount":null,"jensenScore":3246.060125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.853565987300172,"self":"https://pharos.nih.gov/idg/api/v1/targets(11626)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":674,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/properties"},"_links":{"count":1169,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/links"},"_synonyms":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/synonyms"},"_publications":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(11626)/publications"},"_namespace":null},{"id":11627,"version":2,"created":1554945059000,"modified":1554945063000,"deprecated":false,"name":"Serine/arginine-rich splicing factor 10","accession":"O75494","gene":"SRSF10","description":"Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). 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The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.0281176762191966,"antibodyCount":156,"monoclonalCount":6,"pubmedCount":null,"jensenScore":104.724235,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":43.01311936865416,"pubTatorScore":1.5843475214145744,"self":"https://pharos.nih.gov/idg/api/v1/targets(11630)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(11630)/publications"},"_namespace":null},{"id":11631,"version":2,"created":1554945080000,"modified":1554945083000,"deprecated":false,"name":"Carbonic anhydrase-related protein 11","accession":"O75493","gene":"CA11","description":"Does not have a catalytic activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7800792483945788,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.424801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.111340577582123,"pubTatorScore":1.4478468187641966,"self":"https://pharos.nih.gov/idg/api/v1/targets(11631)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(11631)/publications"},"_namespace":null},{"id":11632,"version":2,"created":1554945084000,"modified":1554945088000,"deprecated":false,"name":"Myb-related protein B","accession":"P10244","gene":"MYBL2","description":"Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. 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In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.","idgFamily":"Nuclear Receptor","idgTDL":"Tclin","novelty":-2.973389116870858,"antibodyCount":562,"monoclonalCount":210,"pubmedCount":null,"jensenScore":919.309061,"patentCount":71249,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":55.97662471320314,"pubTatorScore":3.0252598546534926,"self":"https://pharos.nih.gov/idg/api/v1/targets(11691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":682,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/properties"},"_links":{"count":1235,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/links"},"_synonyms":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/synonyms"},"_publications":{"count":311,"href":"https://pharos.nih.gov/idg/api/v1/targets(11691)/publications"},"_namespace":null},{"id":11692,"version":3,"created":1554945754000,"modified":1555040198000,"deprecated":false,"name":"Myosin-9","accession":"P35579","gene":"MYH9","description":"Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. 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For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. 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Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). 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Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.2065798310592153,"antibodyCount":264,"monoclonalCount":28,"pubmedCount":null,"jensenScore":1755.9076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.80867750584238,"pubTatorScore":3.1812251367572446,"self":"https://pharos.nih.gov/idg/api/v1/targets(11744)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/properties"},"_links":{"count":1825,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/synonyms"},"_publications":{"count":609,"href":"https://pharos.nih.gov/idg/api/v1/targets(11744)/publications"},"_namespace":null},{"id":11745,"version":2,"created":1554946510000,"modified":1554946510000,"deprecated":false,"name":"Endogenous retrovirus group K member 10 Pro protein","accession":"P10265","gene":"ERVK-10","description":"Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. 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May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-1.70130823174566,"antibodyCount":273,"monoclonalCount":47,"pubmedCount":null,"jensenScore":47.147374,"patentCount":9777,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.86343495481168,"pubTatorScore":1.4141109355235524,"self":"https://pharos.nih.gov/idg/api/v1/targets(11820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(11820)/publications"},"_namespace":null},{"id":11821,"version":2,"created":1554947263000,"modified":1554947267000,"deprecated":false,"name":"Claudin-4","accession":"O14493","gene":"CLDN4","description":"Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. 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May be involved in cell adhesion and in cell-cell interactions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7785795021021387,"antibodyCount":94,"monoclonalCount":5,"pubmedCount":null,"jensenScore":65.051167,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.5409749422266534,"self":"https://pharos.nih.gov/idg/api/v1/targets(11822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(11822)/publications"},"_namespace":null},{"id":11823,"version":2,"created":1554947273000,"modified":1554947286000,"deprecated":false,"name":"Cadherin-1","accession":"P12830","gene":"CDH1","description":"E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. 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Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. 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Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.237238185724665,"antibodyCount":201,"monoclonalCount":28,"pubmedCount":null,"jensenScore":155.111391,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":30.122619771844604,"pubTatorScore":2.1045679194417355,"self":"https://pharos.nih.gov/idg/api/v1/targets(11826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(11826)/publications"},"_namespace":null},{"id":11827,"version":2,"created":1554947301000,"modified":1554947305000,"deprecated":false,"name":"EH domain-containing protein 4","accession":"Q9H223","gene":"EHD4","description":"ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. 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Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1472836485833644,"antibodyCount":55,"monoclonalCount":12,"pubmedCount":null,"jensenScore":13.641243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.93291096447332,"pubTatorScore":1.2216939220962266,"self":"https://pharos.nih.gov/idg/api/v1/targets(11829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(11829)/publications"},"_namespace":null},{"id":11830,"version":4,"created":1554947315000,"modified":1555040285000,"deprecated":false,"name":"Aromatase","accession":"P11511","gene":"CYP19A1","description":"Catalyzes the formation of aromatic C18 estrogens from C19 androgens.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.38322000907216,"antibodyCount":449,"monoclonalCount":47,"pubmedCount":null,"jensenScore":2408.952882,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":45.301284678179336,"pubTatorScore":3.1787955068929907,"self":"https://pharos.nih.gov/idg/api/v1/targets(11830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/properties"},"_links":{"count":2584,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/links"},"_synonyms":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/synonyms"},"_publications":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(11830)/publications"},"_namespace":null},{"id":11831,"version":3,"created":1554947696000,"modified":1555040291000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 2","accession":"Q9H1P3","gene":"OSBPL2","description":"Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). 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May act as a repressor. During embryonic development, plays a role in palatogenesis.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6672025370708525,"antibodyCount":310,"monoclonalCount":35,"pubmedCount":null,"jensenScore":53.785593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.126700223935725,"pubTatorScore":1.7451615558893085,"self":"https://pharos.nih.gov/idg/api/v1/targets(11998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(11998)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(11998)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(11998)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(11998)/publications"},"_namespace":null},{"id":11999,"version":2,"created":1554948892000,"modified":1554948896000,"deprecated":false,"name":"Golgin subfamily A member 5","accession":"Q8TBA6","gene":"GOLGA5","description":"Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1222008486866109,"antibodyCount":201,"monoclonalCount":59,"pubmedCount":null,"jensenScore":14.527198,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.10607595089062,"pubTatorScore":1.1908411209065146,"self":"https://pharos.nih.gov/idg/api/v1/targets(11999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(11999)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(11999)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(11999)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(11999)/publications"},"_namespace":null},{"id":12000,"version":3,"created":1554948897000,"modified":1555040381000,"deprecated":false,"name":"Interferon regulatory factor 7","accession":"Q92985","gene":"IRF7","description":"Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.488117975313895,"antibodyCount":464,"monoclonalCount":102,"pubmedCount":null,"jensenScore":287.465941,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.19240939722766,"pubTatorScore":2.321139677248616,"self":"https://pharos.nih.gov/idg/api/v1/targets(12000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":524,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/synonyms"},"_publications":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(12000)/publications"},"_namespace":null}]}