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During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9081)/publications"},"_namespace":null},{"id":9082,"version":2,"created":1554922273000,"modified":1554922275000,"deprecated":false,"name":"NACHT, LRR and PYD domains-containing protein 11","accession":"P59045","gene":"NLRP11","description":"Involved in inflammation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.845297187972665,"antibodyCount":80,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.456612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.941884404224915,"pubTatorScore":0.7721962420537455,"self":"https://pharos.nih.gov/idg/api/v1/targets(9082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/properties"},"_links":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(9082)/publications"},"_namespace":null},{"id":9083,"version":2,"created":1554922275000,"modified":1554922278000,"deprecated":false,"name":"60S ribosomal protein L27","accession":"P61353","gene":"RPL27","description":"Component of the large ribosomal subunit (PubMed:12962325). 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Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1774334551606922,"antibodyCount":235,"monoclonalCount":60,"pubmedCount":null,"jensenScore":12.607995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":37.72478922049963,"pubTatorScore":1.2038947154110307,"self":"https://pharos.nih.gov/idg/api/v1/targets(9172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/properties"},"_links":{"count":1076,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(9172)/publications"},"_namespace":null},{"id":9173,"version":3,"created":1554922756000,"modified":1555038700000,"deprecated":false,"name":"Trichohyalin","accession":"Q07283","gene":"TCHH","description":"Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. 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Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. 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It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. 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The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. 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Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). 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Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3443767136268676,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.06681,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.36144067086864,"pubTatorScore":1.6858909490875342,"self":"https://pharos.nih.gov/idg/api/v1/targets(9751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(9751)/publications"},"_namespace":null},{"id":9752,"version":2,"created":1554925401000,"modified":1554925405000,"deprecated":false,"name":"Proteasome subunit alpha type-3","accession":"P25788","gene":"PSMA3","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.209805927700631,"antibodyCount":181,"monoclonalCount":13,"pubmedCount":null,"jensenScore":15.830553,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.09413907476266,"pubTatorScore":1.191031608848618,"self":"https://pharos.nih.gov/idg/api/v1/targets(9752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/synonyms"},"_publications":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(9752)/publications"},"_namespace":null},{"id":9753,"version":3,"created":1554925406000,"modified":1555038951000,"deprecated":false,"name":"Transmembrane emp24 domain-containing protein 10","accession":"P49755","gene":"TMED10","description":"Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4664381513667615,"antibodyCount":300,"monoclonalCount":6,"pubmedCount":null,"jensenScore":31.937383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":42.937554035513614,"pubTatorScore":1.5816271554628505,"self":"https://pharos.nih.gov/idg/api/v1/targets(9753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":473,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/properties"},"_links":{"count":1210,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(9753)/publications"},"_namespace":null},{"id":9754,"version":3,"created":1554925411000,"modified":1555038953000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 41 homolog","accession":"P49754","gene":"VPS41","description":"Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.122278882686007,"antibodyCount":93,"monoclonalCount":2,"pubmedCount":null,"jensenScore":14.388702,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.25356086202082,"pubTatorScore":1.369377833890063,"self":"https://pharos.nih.gov/idg/api/v1/targets(9754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9754)/publications"},"_namespace":null},{"id":9755,"version":2,"created":1554925415000,"modified":1554925419000,"deprecated":false,"name":"PDZ domain-containing protein 8","accession":"Q8NEN9","gene":"PDZD8","description":"Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7363964988022866,"antibodyCount":60,"monoclonalCount":9,"pubmedCount":null,"jensenScore":5.75,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.84470727589008,"pubTatorScore":0.6197887930319512,"self":"https://pharos.nih.gov/idg/api/v1/targets(9755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9755)/publications"},"_namespace":null},{"id":9756,"version":3,"created":1554925419000,"modified":1555038954000,"deprecated":false,"name":"Acyl-coenzyme A thioesterase 2, mitochondrial","accession":"P49753","gene":"ACOT2","description":"Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1995475646360778,"antibodyCount":93,"monoclonalCount":4,"pubmedCount":null,"jensenScore":15.431916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":32.70987032744543,"pubTatorScore":0.9705534192262603,"self":"https://pharos.nih.gov/idg/api/v1/targets(9756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(9756)/publications"},"_namespace":null},{"id":9757,"version":2,"created":1554925422000,"modified":1554925439000,"deprecated":false,"name":"Dual specificity protein kinase CLK1","accession":"P49759","gene":"CLK1","description":"Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.937203365666547,"antibodyCount":156,"monoclonalCount":3,"pubmedCount":null,"jensenScore":87.903235,"patentCount":25929,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.37062835321605,"pubTatorScore":1.789032683122469,"self":"https://pharos.nih.gov/idg/api/v1/targets(9757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(9757)/publications"},"_namespace":null},{"id":9758,"version":2,"created":1554925440000,"modified":1554925443000,"deprecated":false,"name":"Proteasome subunit alpha type-2","accession":"P25787","gene":"PSMA2","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8234586398416596,"antibodyCount":245,"monoclonalCount":110,"pubmedCount":null,"jensenScore":5.780531,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.86574454944142,"pubTatorScore":1.1271433645951732,"self":"https://pharos.nih.gov/idg/api/v1/targets(9758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":523,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/links"},"_synonyms":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/synonyms"},"_publications":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(9758)/publications"},"_namespace":null},{"id":9759,"version":3,"created":1554925444000,"modified":1555038955000,"deprecated":false,"name":"Regulator of G-protein signaling 6","accession":"P49758","gene":"RGS6","description":"Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4499561695416947,"antibodyCount":90,"monoclonalCount":5,"pubmedCount":null,"jensenScore":31.190554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.71615881556692,"pubTatorScore":1.3239216970037058,"self":"https://pharos.nih.gov/idg/api/v1/targets(9759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/links"},"_synonyms":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(9759)/publications"},"_namespace":null},{"id":9760,"version":3,"created":1554925449000,"modified":1555038958000,"deprecated":false,"name":"Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha","accession":"P48426","gene":"PIP4K2A","description":"Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.778949521967724,"antibodyCount":244,"monoclonalCount":51,"pubmedCount":null,"jensenScore":57.39335,"patentCount":1480,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":77,"knowledgeAvailability":44.74193747886373,"pubTatorScore":1.6243348888063074,"self":"https://pharos.nih.gov/idg/api/v1/targets(9760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(9760)/publications"},"_namespace":null},{"id":9761,"version":3,"created":1554925454000,"modified":1555038960000,"deprecated":false,"name":"Proteasome subunit alpha type-1","accession":"P25786","gene":"PSMA1","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.3637531889424304,"antibodyCount":235,"monoclonalCount":36,"pubmedCount":null,"jensenScore":17.378043,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":45.287023459861835,"pubTatorScore":1.1881786859263397,"self":"https://pharos.nih.gov/idg/api/v1/targets(9761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(9761)/publications"},"_namespace":null},{"id":9762,"version":3,"created":1554925460000,"modified":1555038962000,"deprecated":false,"name":"Protein numb homolog","accession":"P49757","gene":"NUMB","description":"Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.600724420049279,"antibodyCount":564,"monoclonalCount":256,"pubmedCount":null,"jensenScore":402.121018,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":47.28640623178152,"pubTatorScore":2.446631457453339,"self":"https://pharos.nih.gov/idg/api/v1/targets(9762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/properties"},"_links":{"count":1227,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(9762)/publications"},"_namespace":null},{"id":9763,"version":3,"created":1554925466000,"modified":1555038964000,"deprecated":false,"name":"Dematin","accession":"Q08495","gene":"DMTN","description":"Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7368645460091845,"antibodyCount":158,"monoclonalCount":3,"pubmedCount":null,"jensenScore":56.577755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":35.38906846152416,"pubTatorScore":1.4647913323653932,"self":"https://pharos.nih.gov/idg/api/v1/targets(9763)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/links"},"_synonyms":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(9763)/publications"},"_namespace":null},{"id":9764,"version":4,"created":1554925471000,"modified":1555038965000,"deprecated":false,"name":"Liver carboxylesterase 1","accession":"P23141","gene":"CES1","description":"Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. 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Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0738665178089835,"antibodyCount":148,"monoclonalCount":106,"pubmedCount":null,"jensenScore":119.092586,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":41.83996376628568,"pubTatorScore":1.9309810394769116,"self":"https://pharos.nih.gov/idg/api/v1/targets(9814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(9814)/publications"},"_namespace":null},{"id":9815,"version":2,"created":1554925890000,"modified":1554925891000,"deprecated":false,"name":"Beta-defensin 108B","accession":"Q8NET1","gene":"DEFB108B","description":"Has antibacterial activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.010995386147214755,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.3,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.66261174669924,"pubTatorScore":0.8846066001802988,"self":"https://pharos.nih.gov/idg/api/v1/targets(9815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/properties"},"_links":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9815)/publications"},"_namespace":null},{"id":9816,"version":3,"created":1554925891000,"modified":1555039008000,"deprecated":false,"name":"Biotin--protein ligase","accession":"P50747","gene":"HLCS","description":"Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3400400875870413,"antibodyCount":86,"monoclonalCount":12,"pubmedCount":null,"jensenScore":223.295569,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.84480289094735,"pubTatorScore":2.4947751108870873,"self":"https://pharos.nih.gov/idg/api/v1/targets(9816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(9816)/publications"},"_namespace":null},{"id":9817,"version":2,"created":1554925897000,"modified":1554925899000,"deprecated":false,"name":"Retrotransposon Gag-like protein 9","accession":"Q8NET4","gene":"RTL9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7690958700921147,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.860715,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6858482843839785,"self":"https://pharos.nih.gov/idg/api/v1/targets(9817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/properties"},"_links":{"count":713,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9817)/publications"},"_namespace":null},{"id":9818,"version":2,"created":1554925899000,"modified":1554925902000,"deprecated":false,"name":"Caveolae-associated protein 3","accession":"Q969G5","gene":"CAVIN3","description":"Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3979551006675086,"antibodyCount":150,"monoclonalCount":16,"pubmedCount":null,"jensenScore":28.708338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.62271962460745,"self":"https://pharos.nih.gov/idg/api/v1/targets(9818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(9818)/publications"},"_namespace":null},{"id":9819,"version":2,"created":1554925903000,"modified":1554925906000,"deprecated":false,"name":"Docosahexaenoic acid omega-hydroxylase CYP4F3","accession":"Q08477","gene":"CYP4F3","description":"Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7068293286950802,"antibodyCount":114,"monoclonalCount":57,"pubmedCount":null,"jensenScore":50.668467,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.247220942938988,"pubTatorScore":3.682380571944615,"self":"https://pharos.nih.gov/idg/api/v1/targets(9819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9819)/publications"},"_namespace":null},{"id":9820,"version":3,"created":1554925907000,"modified":1555039009000,"deprecated":false,"name":"NFAT activation molecule 1","accession":"Q8NET5","gene":"NFAM1","description":"May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.37211722077706094,"antibodyCount":74,"monoclonalCount":8,"pubmedCount":null,"jensenScore":3.318022,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.3411304735338,"pubTatorScore":0.39872797219664635,"self":"https://pharos.nih.gov/idg/api/v1/targets(9820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/properties"},"_links":{"count":866,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(9820)/publications"},"_namespace":null},{"id":9821,"version":2,"created":1554925910000,"modified":1554925913000,"deprecated":false,"name":"Riboflavin kinase","accession":"Q969G6","gene":"RFK","description":"Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7183962853594612,"antibodyCount":104,"monoclonalCount":2,"pubmedCount":null,"jensenScore":55.587413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.297102027417175,"pubTatorScore":1.2361591801535958,"self":"https://pharos.nih.gov/idg/api/v1/targets(9821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/properties"},"_links":{"count":970,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(9821)/publications"},"_namespace":null},{"id":9822,"version":2,"created":1554925914000,"modified":1554925916000,"deprecated":false,"name":"Beta-defensin 124","accession":"Q8NES8","gene":"DEFB124","description":"Has antibacterial activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.2668757204167084,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.762338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.389090851216249,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(9822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/properties"},"_links":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9822)/publications"},"_namespace":null},{"id":9823,"version":3,"created":1554925916000,"modified":1555039010000,"deprecated":false,"name":"Ras association domain-containing protein 2","accession":"P50749","gene":"RASSF2","description":"Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.440374501122644,"antibodyCount":124,"monoclonalCount":11,"pubmedCount":null,"jensenScore":31.953888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.34786680911983,"pubTatorScore":1.4642497399533616,"self":"https://pharos.nih.gov/idg/api/v1/targets(9823)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(9823)/publications"},"_namespace":null},{"id":9824,"version":2,"created":1554925921000,"modified":1554925925000,"deprecated":false,"name":"Kinetochore-associated protein 1","accession":"P50748","gene":"KNTC1","description":"Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.554700999707938,"antibodyCount":105,"monoclonalCount":50,"pubmedCount":null,"jensenScore":354.990033,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.404643174737934,"pubTatorScore":1.1385764227138597,"self":"https://pharos.nih.gov/idg/api/v1/targets(9824)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9824)/publications"},"_namespace":null},{"id":9825,"version":2,"created":1554925926000,"modified":1554925928000,"deprecated":false,"name":"Zinc finger protein 879","accession":"B4DU55","gene":"ZNF879","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.15503411323135,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9825)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(9825)/publications"},"_namespace":null},{"id":9826,"version":3,"created":1554925929000,"modified":1555039012000,"deprecated":false,"name":"Adenylate cyclase type 2","accession":"Q08462","gene":"ADCY2","description":"Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.371655625739674,"antibodyCount":117,"monoclonalCount":9,"pubmedCount":null,"jensenScore":21.428165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":45.607670530043144,"pubTatorScore":2.1160661154210643,"self":"https://pharos.nih.gov/idg/api/v1/targets(9826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(9826)/publications"},"_namespace":null},{"id":9827,"version":2,"created":1554925933000,"modified":1554925935000,"deprecated":false,"name":"Fetal and adult testis-expressed transcript protein","accession":"Q969F0","gene":"FATE1","description":"Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3873897898579945,"antibodyCount":201,"monoclonalCount":162,"pubmedCount":null,"jensenScore":22.453332,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.299048714966984,"pubTatorScore":0.7659167691498038,"self":"https://pharos.nih.gov/idg/api/v1/targets(9827)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/properties"},"_links":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9827)/publications"},"_namespace":null},{"id":9828,"version":2,"created":1554925936000,"modified":1554925936000,"deprecated":false,"name":"Immunoglobulin gamma-1 heavy chain","accession":"P0DOX5","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9828)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9828)/publications"},"_namespace":null},{"id":9829,"version":2,"created":1554925936000,"modified":1554925936000,"deprecated":false,"name":"Immunoglobulin mu heavy chain","accession":"P0DOX6","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9829)/publications"},"_namespace":null},{"id":9830,"version":3,"created":1554925936000,"modified":1555039013000,"deprecated":false,"name":"Protein naked cuticle homolog 2","accession":"Q969F2","gene":"NKD2","description":"Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2984303744709966,"antibodyCount":121,"monoclonalCount":5,"pubmedCount":null,"jensenScore":19.722532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":27.897171764592404,"pubTatorScore":1.1934636332718036,"self":"https://pharos.nih.gov/idg/api/v1/targets(9830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(9830)/publications"},"_namespace":null},{"id":9831,"version":4,"created":1554925939000,"modified":1555039015000,"deprecated":false,"name":"Cyclin-dependent kinase 9","accession":"P50750","gene":"CDK9","description":"Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.0154456847299227,"antibodyCount":372,"monoclonalCount":68,"pubmedCount":null,"jensenScore":918.281001,"patentCount":62312,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":50.290220979822315,"pubTatorScore":2.569604758295301,"self":"https://pharos.nih.gov/idg/api/v1/targets(9831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":757,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/properties"},"_links":{"count":1432,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/synonyms"},"_publications":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(9831)/publications"},"_namespace":null},{"id":9832,"version":2,"created":1554925997000,"modified":1554925997000,"deprecated":false,"name":"Immunoglobulin kappa light chain","accession":"P0DOX7","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(9832)/publications"},"_namespace":null},{"id":9833,"version":2,"created":1554925997000,"modified":1554925999000,"deprecated":false,"name":"General transcription factor 3C polypeptide 6","accession":"Q969F1","gene":"GTF3C6","description":"Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.34678748579036184,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.360294,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.680744969582552,"pubTatorScore":-0.3467874862246563,"self":"https://pharos.nih.gov/idg/api/v1/targets(9833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9833)/publications"},"_namespace":null},{"id":9834,"version":2,"created":1554926000000,"modified":1554926000000,"deprecated":false,"name":"Immunoglobulin lambda-1 light chain","accession":"P0DOX8","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9834)/publications"},"_namespace":null},{"id":9835,"version":2,"created":1554926000000,"modified":1554926002000,"deprecated":false,"name":"Glutamate-rich protein 6B","accession":"Q5W0A0","gene":"ERICH6B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.88079032854979,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/properties"},"_links":{"count":645,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9835)/publications"},"_namespace":null},{"id":9836,"version":3,"created":1554926003000,"modified":1555039018000,"deprecated":false,"name":"Twinfilin-2","accession":"Q6IBS0","gene":"TWF2","description":"Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2487903578873696,"antibodyCount":162,"monoclonalCount":6,"pubmedCount":null,"jensenScore":17.754055,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":34.03366648544167,"pubTatorScore":0.8419848045901139,"self":"https://pharos.nih.gov/idg/api/v1/targets(9836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(9836)/publications"},"_namespace":null},{"id":9837,"version":3,"created":1554926006000,"modified":1554926051000,"deprecated":false,"name":"KiSS-1 receptor","accession":"Q969F8","gene":"KISS1R","description":"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.451581097528305,"antibodyCount":223,"monoclonalCount":1,"pubmedCount":null,"jensenScore":266.496529,"patentCount":15461,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.03449363003225,"pubTatorScore":2.3313304836166817,"self":"https://pharos.nih.gov/idg/api/v1/targets(9837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/synonyms"},"_publications":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(9837)/publications"},"_namespace":null},{"id":9838,"version":2,"created":1554926052000,"modified":1554926056000,"deprecated":false,"name":"Hermansky-Pudlak syndrome 3 protein","accession":"Q969F9","gene":"HPS3","description":"Involved in early stages of melanosome biogenesis and maturation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2480706343727457,"antibodyCount":141,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.434481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.06857136684026,"pubTatorScore":1.2595028777308703,"self":"https://pharos.nih.gov/idg/api/v1/targets(9838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(9838)/publications"},"_namespace":null},{"id":9839,"version":2,"created":1554926057000,"modified":1554926060000,"deprecated":false,"name":"Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe","accession":"Q8NES3","gene":"LFNG","description":"Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.505351954841353,"antibodyCount":220,"monoclonalCount":99,"pubmedCount":null,"jensenScore":29.757306,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.15407474535347,"pubTatorScore":1.3562162927853136,"self":"https://pharos.nih.gov/idg/api/v1/targets(9839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9839)/publications"},"_namespace":null},{"id":9840,"version":2,"created":1554926061000,"modified":1554926062000,"deprecated":false,"name":"Chimeric ERCC6-PGBD3 protein","accession":"P0DP91","gene":"ERCC6","description":"Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.317763740386917,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":361.474783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.962018690949584,"pubTatorScore":2.274750976766077,"self":"https://pharos.nih.gov/idg/api/v1/targets(9840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/properties"},"_links":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/synonyms"},"_publications":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(9840)/publications"},"_namespace":null},{"id":9841,"version":2,"created":1554926063000,"modified":1554926063000,"deprecated":false,"name":"Immunoglobulin alpha-2 heavy chain","accession":"P0DOX2","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9841)/publications"},"_namespace":null},{"id":9842,"version":2,"created":1554926063000,"modified":1554926063000,"deprecated":false,"name":"Immunoglobulin delta heavy chain","accession":"P0DOX3","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum is below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:11282392, PubMed:10702483, PubMed:16895553).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(9842)/publications"},"_namespace":null},{"id":9843,"version":2,"created":1554926064000,"modified":1554926064000,"deprecated":false,"name":"Immunoglobulin epsilon heavy chain","accession":"P0DOX4","gene":null,"description":"Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9843)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(9843)/publications"},"_namespace":null},{"id":9844,"version":2,"created":1554926064000,"modified":1554926067000,"deprecated":false,"name":"Neuronal PAS domain-containing protein 3","accession":"Q8IXF0","gene":"NPAS3","description":"May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4942158720812069,"antibodyCount":112,"monoclonalCount":2,"pubmedCount":null,"jensenScore":32.430932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.69102639187412,"pubTatorScore":1.5259288820667398,"self":"https://pharos.nih.gov/idg/api/v1/targets(9844)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(9844)/publications"},"_namespace":null},{"id":9845,"version":3,"created":1554926068000,"modified":1555039019000,"deprecated":false,"name":"Lysophosphatidylcholine acyltransferase 1","accession":"Q8NF37","gene":"LPCAT1","description":"Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). 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VCPIP1 is also required, but not its deubiquitinating activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.23408320494763177,"antibodyCount":73,"monoclonalCount":43,"pubmedCount":null,"jensenScore":0.708333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":29.876094119867442,"pubTatorScore":0.6812412373755872,"self":"https://pharos.nih.gov/idg/api/v1/targets(9878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9878)/publications"},"_namespace":null},{"id":9879,"version":2,"created":1554926717000,"modified":1554926720000,"deprecated":false,"name":"CXXC-type zinc finger protein 5","accession":"Q7LFL8","gene":"CXXC5","description":"May indirectly participate in activation of the NF-kappa-B and MAPK pathways. 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May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0790053055666924,"antibodyCount":97,"monoclonalCount":3,"pubmedCount":null,"jensenScore":121.761838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.383238686133694,"pubTatorScore":1.436480218111925,"self":"https://pharos.nih.gov/idg/api/v1/targets(9879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(9879)/publications"},"_namespace":null},{"id":9880,"version":2,"created":1554926721000,"modified":1554926725000,"deprecated":false,"name":"Retinoic acid-induced protein 3","accession":"Q8NFJ5","gene":"GPRC5A","description":"Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.5169174624473412,"antibodyCount":294,"monoclonalCount":19,"pubmedCount":null,"jensenScore":37.729181,"patentCount":13444,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.21255177425229,"pubTatorScore":1.465224007455352,"self":"https://pharos.nih.gov/idg/api/v1/targets(9880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(9880)/publications"},"_namespace":null},{"id":9881,"version":2,"created":1554926726000,"modified":1554926729000,"deprecated":false,"name":"Prokineticin receptor 2","accession":"Q8NFJ6","gene":"PROKR2","description":"Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.683314811205036,"antibodyCount":155,"monoclonalCount":0,"pubmedCount":null,"jensenScore":49.290041,"patentCount":14366,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.24229647075051,"pubTatorScore":1.8382486508225022,"self":"https://pharos.nih.gov/idg/api/v1/targets(9881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/properties"},"_links":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(9881)/publications"},"_namespace":null},{"id":9882,"version":3,"created":1554926729000,"modified":1555039043000,"deprecated":false,"name":"Bardet-Biedl syndrome 1 protein","accession":"Q8NFJ9","gene":"BBS1","description":"The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7903732092261289,"antibodyCount":75,"monoclonalCount":4,"pubmedCount":null,"jensenScore":57.772652,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":41.58250570760431,"pubTatorScore":1.7094621785634398,"self":"https://pharos.nih.gov/idg/api/v1/targets(9882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(9882)/publications"},"_namespace":null},{"id":9883,"version":2,"created":1554926734000,"modified":1554926737000,"deprecated":false,"name":"Class E basic helix-loop-helix protein 22","accession":"Q8NFJ8","gene":"BHLHE22","description":"Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.0288587291620606,"antibodyCount":108,"monoclonalCount":2,"pubmedCount":null,"jensenScore":950.672071,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.605043665996682,"pubTatorScore":1.1010811379122978,"self":"https://pharos.nih.gov/idg/api/v1/targets(9883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9883)/publications"},"_namespace":null},{"id":9884,"version":2,"created":1554926738000,"modified":1554926740000,"deprecated":false,"name":"Leukocyte immunoglobulin-like receptor subfamily A member 1","accession":"O75019","gene":"LILRA1","description":"May act as receptor for class I MHC antigens.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5503252021852654,"antibodyCount":105,"monoclonalCount":24,"pubmedCount":null,"jensenScore":2.338328,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.969986678340042,"pubTatorScore":0.6368220641799052,"self":"https://pharos.nih.gov/idg/api/v1/targets(9884)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/properties"},"_links":{"count":700,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9884)/publications"},"_namespace":null},{"id":9885,"version":2,"created":1554926741000,"modified":1554926743000,"deprecated":false,"name":"Uncharacterized protein C9orf172","accession":"C9J069","gene":"AJM1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9885)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/links"},"_synonyms":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9885)/publications"},"_namespace":null},{"id":9886,"version":2,"created":1554926743000,"modified":1554926743000,"deprecated":false,"name":"Immunoglobulin heavy variable 1-8","accession":"P0DP01","gene":"IGHV1-8","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.7358408658180186,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9886)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9886)/publications"},"_namespace":null},{"id":9887,"version":2,"created":1554926744000,"modified":1554926744000,"deprecated":false,"name":"Immunoglobulin heavy variable 3-30-3","accession":"P0DP02","gene":"IGHV3-30-3","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9887)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9887)/publications"},"_namespace":null},{"id":9888,"version":2,"created":1554926744000,"modified":1554926748000,"deprecated":false,"name":"Annexin A3","accession":"P12429","gene":"ANXA3","description":"Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0146193380924027,"antibodyCount":354,"monoclonalCount":71,"pubmedCount":null,"jensenScore":104.568048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.48393626317517,"pubTatorScore":1.9883098126381322,"self":"https://pharos.nih.gov/idg/api/v1/targets(9888)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(9888)/publications"},"_namespace":null},{"id":9889,"version":2,"created":1554926749000,"modified":1554926749000,"deprecated":false,"name":"Immunoglobulin heavy variable 3-30-5","accession":"P0DP03","gene":"IGHV3-30-5","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9889)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(9889)/publications"},"_namespace":null},{"id":9890,"version":3,"created":1554926749000,"modified":1555039045000,"deprecated":false,"name":"Low affinity immunoglobulin gamma Fc region receptor III-B","accession":"O75015","gene":"FCGR3B","description":"Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.2365794943375086,"antibodyCount":441,"monoclonalCount":397,"pubmedCount":null,"jensenScore":1624.900466,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":23.43858639925446,"pubTatorScore":2.3179849607048575,"self":"https://pharos.nih.gov/idg/api/v1/targets(9890)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(9890)/publications"},"_namespace":null},{"id":9891,"version":2,"created":1554926755000,"modified":1554926757000,"deprecated":false,"name":"Protein crumbs homolog 2","accession":"Q5IJ48","gene":"CRB2","description":"Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4485227984776023,"antibodyCount":92,"monoclonalCount":0,"pubmedCount":null,"jensenScore":30.864919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.682254289516457,"pubTatorScore":1.3013387561173033,"self":"https://pharos.nih.gov/idg/api/v1/targets(9891)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/properties"},"_links":{"count":797,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(9891)/publications"},"_namespace":null},{"id":9892,"version":2,"created":1554926758000,"modified":1554926763000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DRB1-4 beta chain","accession":"P13760","gene":"HLA-DRB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. 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Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2282876131197216,"antibodyCount":267,"monoclonalCount":45,"pubmedCount":null,"jensenScore":176.652593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":44.21507917397478,"pubTatorScore":2.1587733995941654,"self":"https://pharos.nih.gov/idg/api/v1/targets(9961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(9961)/publications"},"_namespace":null},{"id":9962,"version":2,"created":1554927055000,"modified":1554927058000,"deprecated":false,"name":"N-alpha-acetyltransferase 25, NatB auxiliary subunit","accession":"Q14CX7","gene":"NAA25","description":"Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. 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However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.9537858717936727,"antibodyCount":741,"monoclonalCount":279,"pubmedCount":null,"jensenScore":880.998132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":55.45419973305048,"pubTatorScore":2.7810836615921857,"self":"https://pharos.nih.gov/idg/api/v1/targets(9965)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":709,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/properties"},"_links":{"count":1391,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/synonyms"},"_publications":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(9965)/publications"},"_namespace":null},{"id":9966,"version":2,"created":1554927077000,"modified":1554927080000,"deprecated":false,"name":"Adenylate cyclase type 4","accession":"Q8NFM4","gene":"ADCY4","description":"Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0460331137250125,"antibodyCount":156,"monoclonalCount":0,"pubmedCount":null,"jensenScore":107.559948,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.51246220111338,"pubTatorScore":1.651074410129058,"self":"https://pharos.nih.gov/idg/api/v1/targets(9966)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":453,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9966)/publications"},"_namespace":null},{"id":9967,"version":2,"created":1554927081000,"modified":1554927081000,"deprecated":false,"name":"Putative uncharacterized protein LOC100996504","accession":"I3L1I5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9967)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/properties"},"_links":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(9967)/publications"},"_namespace":null},{"id":9968,"version":2,"created":1554927081000,"modified":1554927081000,"deprecated":false,"name":"Putative coiled-coil domain-containing protein 144C","accession":"Q8IYA2","gene":"CCDC144CP","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.745138091704004,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9968)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/properties"},"_links":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(9968)/publications"},"_namespace":null},{"id":9969,"version":3,"created":1554927081000,"modified":1555039095000,"deprecated":false,"name":"Proteasome subunit beta type-2","accession":"P49721","gene":"PSMB2","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.7439013844110007,"antibodyCount":188,"monoclonalCount":38,"pubmedCount":null,"jensenScore":4.716269,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":46.6991949737773,"pubTatorScore":0.35220876800672424,"self":"https://pharos.nih.gov/idg/api/v1/targets(9969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":607,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/properties"},"_links":{"count":1136,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(9969)/publications"},"_namespace":null},{"id":9970,"version":3,"created":1554927100000,"modified":1555039098000,"deprecated":false,"name":"Proteasome subunit beta type-3","accession":"P49720","gene":"PSMB3","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5775356411247482,"antibodyCount":81,"monoclonalCount":7,"pubmedCount":null,"jensenScore":2.935869,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":48,"knowledgeAvailability":42.213939970933666,"pubTatorScore":0.8052410873357109,"self":"https://pharos.nih.gov/idg/api/v1/targets(9970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/properties"},"_links":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(9970)/publications"},"_namespace":null},{"id":9971,"version":3,"created":1554927102000,"modified":1555039098000,"deprecated":false,"name":"Interleukin-17 receptor D","accession":"Q8NFM7","gene":"IL17RD","description":"Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. 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TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7477024446481382,"antibodyCount":325,"monoclonalCount":100,"pubmedCount":null,"jensenScore":44.78134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.161385867276586,"pubTatorScore":1.93814966674101,"self":"https://pharos.nih.gov/idg/api/v1/targets(9980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(9980)/publications"},"_namespace":null},{"id":9981,"version":2,"created":1554927779000,"modified":1554927782000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DO beta chain","accession":"P13765","gene":"HLA-DOB","description":"Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. 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Does not act as an allosteric activator of the cholera toxin catalytic subunit.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.528539299106156,"antibodyCount":311,"monoclonalCount":111,"pubmedCount":null,"jensenScore":37.698628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.594103819909606,"pubTatorScore":1.3758667065676011,"self":"https://pharos.nih.gov/idg/api/v1/targets(9983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/properties"},"_links":{"count":1138,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(9983)/publications"},"_namespace":null},{"id":9984,"version":3,"created":1554927791000,"modified":1555039108000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 2","accession":"P36404","gene":"ARL2","description":"Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). 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In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(9985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2689,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/properties"},"_links":{"count":1238,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/synonyms"},"_publications":{"count":2531,"href":"https://pharos.nih.gov/idg/api/v1/targets(9985)/publications"},"_namespace":null},{"id":9986,"version":2,"created":1554927809000,"modified":1554927810000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DR beta 4 chain","accession":"P13762","gene":"HLA-DRB4","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. 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In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.223161699078588,"pubTatorScore":3.3773864050688718,"self":"https://pharos.nih.gov/idg/api/v1/targets(9986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/properties"},"_links":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(9986)/publications"},"_namespace":null},{"id":9987,"version":2,"created":1554927810000,"modified":1554927813000,"deprecated":false,"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7","accession":"Q8NFL0","gene":"B3GNT7","description":"May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6519025377381527,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.074976,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.533850434761124,"pubTatorScore":0.6861678544425649,"self":"https://pharos.nih.gov/idg/api/v1/targets(9987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(9987)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(9987)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(9987)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9987)/publications"},"_namespace":null},{"id":9988,"version":2,"created":1554927814000,"modified":1554927819000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DRB1-13 beta chain","accession":"Q5Y7A7","gene":"HLA-DRB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(9988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2684,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/properties"},"_links":{"count":1122,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/links"},"_synonyms":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/synonyms"},"_publications":{"count":2548,"href":"https://pharos.nih.gov/idg/api/v1/targets(9988)/publications"},"_namespace":null},{"id":9989,"version":3,"created":1554927829000,"modified":1555039109000,"deprecated":false,"name":"Transport and Golgi organization protein 2 homolog","accession":"Q6ICL3","gene":"TANGO2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6012837673378828,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.127473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.180871488898934,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(9989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/links"},"_synonyms":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(9989)/publications"},"_namespace":null},{"id":9990,"version":2,"created":1554927832000,"modified":1554927835000,"deprecated":false,"name":"Probable palmitoyltransferase ZDHHC20","accession":"Q5W0Z9","gene":"ZDHHC20","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.3891660793701459,"antibodyCount":139,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.403743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.316255960615496,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(9990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(9990)/publications"},"_namespace":null},{"id":9991,"version":2,"created":1554927835000,"modified":1554927840000,"deprecated":false,"name":"Transcriptional repressor CTCF","accession":"P49711","gene":"CTCF","description":"Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.8772600070376426,"antibodyCount":284,"monoclonalCount":61,"pubmedCount":null,"jensenScore":746.514692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.57453990493493,"pubTatorScore":2.718560115398199,"self":"https://pharos.nih.gov/idg/api/v1/targets(9991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":652,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/properties"},"_links":{"count":1303,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/synonyms"},"_publications":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(9991)/publications"},"_namespace":null},{"id":9992,"version":2,"created":1554927841000,"modified":1554927843000,"deprecated":false,"name":"Solute carrier family 35 member E4","accession":"Q6ICL7","gene":"SLC35E4","description":"Putative transporter.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.23640511477795,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(9992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(9992)/publications"},"_namespace":null},{"id":9993,"version":3,"created":1554927844000,"modified":1555039110000,"deprecated":false,"name":"Coagulation factor XIII A chain","accession":"P00488","gene":"F13A1","description":"Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3158712768141467,"antibodyCount":726,"monoclonalCount":423,"pubmedCount":null,"jensenScore":200.753567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.178849926493534,"pubTatorScore":2.701786253401274,"self":"https://pharos.nih.gov/idg/api/v1/targets(9993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":614,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/links"},"_synonyms":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/synonyms"},"_publications":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(9993)/publications"},"_namespace":null},{"id":9994,"version":2,"created":1554927875000,"modified":1554927878000,"deprecated":false,"name":"CCAAT/enhancer-binding protein delta","accession":"P49716","gene":"CEBPD","description":"Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.490290872272222,"antibodyCount":179,"monoclonalCount":2,"pubmedCount":null,"jensenScore":299.92253,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.064747256367355,"pubTatorScore":2.266846538439986,"self":"https://pharos.nih.gov/idg/api/v1/targets(9994)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":345,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(9994)/publications"},"_namespace":null},{"id":9995,"version":2,"created":1554927879000,"modified":1554927884000,"deprecated":false,"name":"CCAAT/enhancer-binding protein alpha","accession":"P49715","gene":"CEBPA","description":"Isoform 4: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.943930253618226,"antibodyCount":518,"monoclonalCount":86,"pubmedCount":null,"jensenScore":846.319965,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.55163136539561,"pubTatorScore":3.02750590893941,"self":"https://pharos.nih.gov/idg/api/v1/targets(9995)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/properties"},"_links":{"count":1212,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/synonyms"},"_publications":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(9995)/publications"},"_namespace":null},{"id":9996,"version":3,"created":1554927886000,"modified":1555039112000,"deprecated":false,"name":"Putative oxidoreductase GLYR1","accession":"Q49A26","gene":"GLYR1","description":"Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.7362510531843296,"antibodyCount":63,"monoclonalCount":6,"pubmedCount":null,"jensenScore":55.847459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.938514709836966,"pubTatorScore":0.9827735930047439,"self":"https://pharos.nih.gov/idg/api/v1/targets(9996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(9996)/publications"},"_namespace":null},{"id":9997,"version":2,"created":1554927890000,"modified":1554927892000,"deprecated":false,"name":"Polypeptide N-acetylgalactosaminyltransferase-like 6","accession":"Q49A17","gene":"GALNTL6","description":"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.1720512788411941,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.56456,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.89780043024031,"pubTatorScore":0.09828645387847472,"self":"https://pharos.nih.gov/idg/api/v1/targets(9997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(9997)/publications"},"_namespace":null},{"id":9998,"version":3,"created":1554927893000,"modified":1555039114000,"deprecated":false,"name":"Ornithine carbamoyltransferase, mitochondrial","accession":"P00480","gene":"OTC","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.217520925963561,"antibodyCount":480,"monoclonalCount":319,"pubmedCount":null,"jensenScore":151.6874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":33.442684356979605,"pubTatorScore":2.972655468322856,"self":"https://pharos.nih.gov/idg/api/v1/targets(9998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/properties"},"_links":{"count":808,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/synonyms"},"_publications":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(9998)/publications"},"_namespace":null},{"id":9999,"version":2,"created":1554927899000,"modified":1554927901000,"deprecated":false,"name":"Kelch repeat and BTB domain-containing protein 13","accession":"C9JR72","gene":"KBTBD13","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4687691742747739,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.858466,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.721500512556156,"pubTatorScore":0.6276583946802454,"self":"https://pharos.nih.gov/idg/api/v1/targets(9999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/properties"},"_links":{"count":593,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(9999)/publications"},"_namespace":null},{"id":10000,"version":3,"created":1554927901000,"modified":1555039115000,"deprecated":false,"name":"Calmodulin-1","accession":"P0DP23","gene":"CALM3","description":"Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.590929562440972,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5859.505004,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.885261128818016,"pubTatorScore":2.785312311942851,"self":"https://pharos.nih.gov/idg/api/v1/targets(10000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":658,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/properties"},"_links":{"count":1636,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/links"},"_synonyms":{"count":527,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/synonyms"},"_publications":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10000)/publications"},"_namespace":null}]}