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Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2300867839480003,"antibodyCount":518,"monoclonalCount":221,"pubmedCount":null,"jensenScore":172.684169,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":46.57854216544793,"pubTatorScore":2.234010369103148,"self":"https://pharos.nih.gov/idg/api/v1/targets(53)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":499,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(53)/publications"},"_namespace":null},{"id":54,"version":2,"created":1554856048000,"modified":1554856055000,"deprecated":false,"name":"Apoptotic chromatin condensation inducer in the nucleus","accession":"Q9UKV3","gene":"ACIN1","description":"Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5198673886776983,"antibodyCount":429,"monoclonalCount":14,"pubmedCount":null,"jensenScore":31.12438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.411551305928015,"pubTatorScore":1.4362667538798783,"self":"https://pharos.nih.gov/idg/api/v1/targets(54)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/properties"},"_links":{"count":1265,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(54)/publications"},"_namespace":null},{"id":55,"version":3,"created":1554856056000,"modified":1555032402000,"deprecated":false,"name":"AN1-type zinc finger protein 4","accession":"Q86XD8","gene":"ZFAND4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.409369470018525,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.616666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.31928535073546,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(55)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/properties"},"_links":{"count":840,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(55)/publications"},"_namespace":null},{"id":56,"version":3,"created":1554856060000,"modified":1554856112000,"deprecated":false,"name":"Histone deacetylase 9","accession":"Q9UKV0","gene":"HDAC9","description":"Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-2.273089497091032,"antibodyCount":431,"monoclonalCount":68,"pubmedCount":null,"jensenScore":185.173288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":56.23984089559329,"pubTatorScore":2.7473718144377592,"self":"https://pharos.nih.gov/idg/api/v1/targets(56)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/properties"},"_links":{"count":1180,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/links"},"_synonyms":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(56)/publications"},"_namespace":null},{"id":57,"version":3,"created":1554856114000,"modified":1555032405000,"deprecated":false,"name":"Protein FAM131B","accession":"Q86XD5","gene":"FAM131B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.10720996964786837,"antibodyCount":27,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.975406,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":28.419123661868465,"pubTatorScore":-0.3316989001708281,"self":"https://pharos.nih.gov/idg/api/v1/targets(57)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/properties"},"_links":{"count":814,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(57)/publications"},"_namespace":null},{"id":58,"version":2,"created":1554856118000,"modified":1554856124000,"deprecated":false,"name":"E3 ubiquitin-protein ligase AMFR","accession":"Q9UKV5","gene":"AMFR","description":"E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.46909370714568,"antibodyCount":203,"monoclonalCount":10,"pubmedCount":null,"jensenScore":292.79011,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.332123968726236,"pubTatorScore":2.0521588108357567,"self":"https://pharos.nih.gov/idg/api/v1/targets(58)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":491,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/properties"},"_links":{"count":1096,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(58)/publications"},"_namespace":null},{"id":59,"version":3,"created":1554856125000,"modified":1555032406000,"deprecated":false,"name":"Myotubularin-related protein 10","accession":"Q9NXD2","gene":"MTMR10","description":"Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.09863683241885936,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.581547,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.564237544316658,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(59)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(59)/publications"},"_namespace":null},{"id":60,"version":2,"created":1554856129000,"modified":1554856133000,"deprecated":false,"name":"WD repeat-containing protein 91","accession":"A4D1P6","gene":"WDR91","description":"Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7290297371187089,"antibodyCount":54,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.455556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.449377626796103,"pubTatorScore":-0.12979104421422474,"self":"https://pharos.nih.gov/idg/api/v1/targets(60)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(60)/publications"},"_namespace":null},{"id":61,"version":3,"created":1554856134000,"modified":1555032409000,"deprecated":false,"name":"Protein argonaute-2","accession":"Q9UKV8","gene":"AGO2","description":"Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.972430242380369,"antibodyCount":202,"monoclonalCount":44,"pubmedCount":null,"jensenScore":867.10533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":49.5380576746982,"pubTatorScore":3.182079452361696,"self":"https://pharos.nih.gov/idg/api/v1/targets(61)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/properties"},"_links":{"count":1348,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/links"},"_synonyms":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/synonyms"},"_publications":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(61)/publications"},"_namespace":null},{"id":62,"version":3,"created":1554856148000,"modified":1555032411000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 10","accession":"Q5BKY1","gene":"LRRC10","description":"May play important roles in cardiac development and/or cardiac function.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9311187105921871,"antibodyCount":42,"monoclonalCount":3,"pubmedCount":null,"jensenScore":8.186527,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":18.954198517230957,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(62)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/properties"},"_links":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(62)/publications"},"_namespace":null},{"id":63,"version":2,"created":1554856150000,"modified":1554856150000,"deprecated":false,"name":"Putative uncharacterized protein DKFZp434K191","accession":"Q5BKY6","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(63)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(63)/publications"},"_namespace":null},{"id":64,"version":3,"created":1554856150000,"modified":1555032413000,"deprecated":false,"name":"5-hydroxytryptamine receptor 3C","accession":"Q8WXA8","gene":"HTR3C","description":"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. 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Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). 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Required for the incorporation of MINOS1/MIC10 into the MICOS complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2234298503668208,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.473778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3730433755813021,"self":"https://pharos.nih.gov/idg/api/v1/targets(313)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(313)/publications"},"_namespace":null},{"id":314,"version":3,"created":1554857757000,"modified":1555032564000,"deprecated":false,"name":"Sorting nexin-8","accession":"Q9Y5X2","gene":"SNX8","description":"May be involved in several stages of intracellular trafficking. 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The immediate electron acceptor for the enzyme is believed to be ubiquinone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.6279426493278188,"antibodyCount":65,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.794264,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.72908359979191,"pubTatorScore":0.5913737369240128,"self":"https://pharos.nih.gov/idg/api/v1/targets(569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(569)/publications"},"_namespace":null},{"id":570,"version":3,"created":1554859228000,"modified":1555032682000,"deprecated":false,"name":"Protein ecdysoneless homolog","accession":"O95905","gene":"ECD","description":"Regulator of p53/TP53 stability and function. 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May play a role in regulation of pre-mRNA splicing (PubMed:24722212).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7224511098365303,"antibodyCount":113,"monoclonalCount":29,"pubmedCount":null,"jensenScore":9.930693,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":31.82522464187388,"pubTatorScore":1.4785727141845941,"self":"https://pharos.nih.gov/idg/api/v1/targets(570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(570)/publications"},"_namespace":null},{"id":571,"version":2,"created":1554859231000,"modified":1554859234000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 13C","accession":"Q96RJ3","gene":"TNFRSF13C","description":"B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. 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Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6389435732694202,"antibodyCount":185,"monoclonalCount":20,"pubmedCount":null,"jensenScore":37.172194,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":41.27191991083502,"pubTatorScore":1.9194172694651233,"self":"https://pharos.nih.gov/idg/api/v1/targets(572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":490,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/properties"},"_links":{"count":1208,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(572)/publications"},"_namespace":null},{"id":573,"version":3,"created":1554859239000,"modified":1555032685000,"deprecated":false,"name":"Monocarboxylate transporter 3","accession":"O95907","gene":"SLC16A8","description":"Proton-linked monocarboxylate transporter. 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Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.4944417054391943,"antibodyCount":117,"monoclonalCount":2,"pubmedCount":null,"jensenScore":308.838744,"patentCount":42640,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.084431388303091,"pubTatorScore":2.0947234213187165,"self":"https://pharos.nih.gov/idg/api/v1/targets(575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/properties"},"_links":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(575)/publications"},"_namespace":null},{"id":576,"version":2,"created":1554859267000,"modified":1554859270000,"deprecated":false,"name":"3-hydroxybutyrate dehydrogenase type 2","accession":"Q9BUT1","gene":"BDH2","description":"Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. 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Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.051975040292868,"antibodyCount":194,"monoclonalCount":46,"pubmedCount":null,"jensenScore":103.280877,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.93205805395832,"pubTatorScore":2.0064524484052617,"self":"https://pharos.nih.gov/idg/api/v1/targets(578)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(578)/publications"},"_namespace":null},{"id":579,"version":2,"created":1554859277000,"modified":1554859280000,"deprecated":false,"name":"2'-5'-oligoadenylate synthase 3","accession":"Q9Y6K5","gene":"OAS3","description":"Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3008338257285097,"antibodyCount":141,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.827496,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.84520077742047,"pubTatorScore":2.0575477292221613,"self":"https://pharos.nih.gov/idg/api/v1/targets(579)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(579)/publications"},"_namespace":null},{"id":580,"version":2,"created":1554859280000,"modified":1554859285000,"deprecated":false,"name":"Neurexin-1","accession":"Q9ULB1","gene":"NRXN1","description":"Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. 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Required for normal trabecular bone mass and cortical bone composition (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-1.7248905183458925,"antibodyCount":555,"monoclonalCount":274,"pubmedCount":null,"jensenScore":55.353477,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":55.64424860530742,"pubTatorScore":2.642694524601589,"self":"https://pharos.nih.gov/idg/api/v1/targets(875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":635,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/properties"},"_links":{"count":1279,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/synonyms"},"_publications":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(875)/publications"},"_namespace":null},{"id":876,"version":3,"created":1554860247000,"modified":1555032860000,"deprecated":false,"name":"NAD-dependent protein lipoamidase sirtuin-4, mitochondrial","accession":"Q9Y6E7","gene":"SIRT4","description":"Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. 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Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). 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May act as a key regulator of axon regeneration in the optic nerve and radial nerve.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.2411032400775732,"antibodyCount":243,"monoclonalCount":21,"pubmedCount":null,"jensenScore":132.946855,"patentCount":36691,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.04200650610785,"pubTatorScore":1.832932379611627,"self":"https://pharos.nih.gov/idg/api/v1/targets(877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/links"},"_synonyms":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(877)/publications"},"_namespace":null},{"id":878,"version":2,"created":1554860256000,"modified":1554860259000,"deprecated":false,"name":"Serine/threonine-protein kinase VRK2","accession":"Q86Y07","gene":"VRK2","description":"Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. 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May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, 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Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). 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Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.9452644104964283,"antibodyCount":215,"monoclonalCount":10,"pubmedCount":null,"jensenScore":841.849063,"patentCount":52493,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.069459559801906,"pubTatorScore":2.4431387771264363,"self":"https://pharos.nih.gov/idg/api/v1/targets(957)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(957)/publications"},"_namespace":null},{"id":958,"version":2,"created":1554860837000,"modified":1554860840000,"deprecated":false,"name":"Arginine and glutamate-rich protein 1","accession":"Q9NWB6","gene":"ARGLU1","description":"Required for the estrogen-dependent expression of ESR1 target genes. 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Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3103078165210995,"antibodyCount":197,"monoclonalCount":81,"pubmedCount":null,"jensenScore":23.778247,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":37,"knowledgeAvailability":37.06892612559948,"pubTatorScore":1.0583550661791215,"self":"https://pharos.nih.gov/idg/api/v1/targets(961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(961)/publications"},"_namespace":null},{"id":962,"version":2,"created":1554860858000,"modified":1554860860000,"deprecated":false,"name":"E3 ubiquitin ligase RNF157","accession":"Q96PX1","gene":"RNF157","description":"E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). 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Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. 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Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). 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