{"id":327292,"version":1,"created":1584652252916,"modified":1584652252921,"deprecated":false,"etag":"f0a9918e5ed2257a","uri":"https://pharos.nih.gov/idg/api/v1/targets?top=1000&skip=5000","path":"/idg/api/v1/targets","method":"GET","sha1":"97018d676813cb41bf1f03d84edfcc589327cc0f","total":20244,"count":1000,"skip":5000,"top":1000,"status":null,"query":"skip=5000&top=1000","filter":null,"_namespace":null,"content":[{"id":5001,"version":3,"created":1554893492000,"modified":1555035984000,"deprecated":false,"name":"FYVE, RhoGEF and PH domain-containing protein 5","accession":"Q6ZNL6","gene":"FGD5","description":"Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7965930896649616,"antibodyCount":64,"monoclonalCount":3,"pubmedCount":null,"jensenScore":8.162502,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.993875927647796,"pubTatorScore":0.14168394706254614,"self":"https://pharos.nih.gov/idg/api/v1/targets(5001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(5001)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(5001)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(5001)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(5001)/publications"},"_namespace":null},{"id":5002,"version":3,"created":1554893495000,"modified":1555035985000,"deprecated":false,"name":"Slit homolog 2 protein","accession":"O94813","gene":"SLIT2","description":"Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.017650510526691,"antibodyCount":215,"monoclonalCount":50,"pubmedCount":null,"jensenScore":103.967411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":45.39416266440511,"pubTatorScore":2.1032639714249433,"self":"https://pharos.nih.gov/idg/api/v1/targets(5002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":461,"href":"https://pharos.nih.gov/idg/api/v1/targets(5002)/properties"},"_links":{"count":1055,"href":"https://pharos.nih.gov/idg/api/v1/targets(5002)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(5002)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(5002)/publications"},"_namespace":null},{"id":5003,"version":2,"created":1554893500000,"modified":1554893502000,"deprecated":false,"name":"Kelch repeat and BTB domain-containing protein 11","accession":"O94819","gene":"KBTBD11","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.6489680513254608,"antibodyCount":26,"monoclonalCount":1,"pubmedCount":null,"jensenScore":39.647911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.671879761860556,"pubTatorScore":-1.1461254299191639,"self":"https://pharos.nih.gov/idg/api/v1/targets(5003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(5003)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(5003)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(5003)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(5003)/publications"},"_namespace":null},{"id":5004,"version":3,"created":1554893503000,"modified":1555035987000,"deprecated":false,"name":"Collectin-11","accession":"Q9BWP8","gene":"COLEC11","description":"Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3821810409828823,"antibodyCount":105,"monoclonalCount":2,"pubmedCount":null,"jensenScore":25.303474,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":28.809941581245848,"pubTatorScore":0.893550387258747,"self":"https://pharos.nih.gov/idg/api/v1/targets(5004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(5004)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(5004)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(5004)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(5004)/publications"},"_namespace":null},{"id":5005,"version":3,"created":1554893506000,"modified":1555035988000,"deprecated":false,"name":"Ubiquitin-like protein ATG12","accession":"O94817","gene":"ATG12","description":"(Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.17957849241074,"antibodyCount":528,"monoclonalCount":138,"pubmedCount":null,"jensenScore":122.108818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.13993481529662,"pubTatorScore":1.8205828928941756,"self":"https://pharos.nih.gov/idg/api/v1/targets(5005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(5005)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(5005)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(5005)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(5005)/publications"},"_namespace":null},{"id":5006,"version":2,"created":1554893509000,"modified":1554893512000,"deprecated":false,"name":"Nucleolar protein 4","accession":"O94818","gene":"NOL4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7834223336398449,"antibodyCount":91,"monoclonalCount":11,"pubmedCount":null,"jensenScore":5.345852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.310406714260637,"pubTatorScore":0.7106220554894068,"self":"https://pharos.nih.gov/idg/api/v1/targets(5006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(5006)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(5006)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(5006)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(5006)/publications"},"_namespace":null},{"id":5007,"version":2,"created":1554893512000,"modified":1554893515000,"deprecated":false,"name":"Sphingosine-1-phosphate phosphatase 1","accession":"Q9BX95","gene":"SGPP1","description":"Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phoshate, lysophosphatidic acid or phosphatidic acid. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:12815058, PubMed:11756451). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide though a phosphorylation/dephosphorylation cycle. Regulates intracellular ceramide levels, which in turn regulate apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9066630455504143,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.544456,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.934317350338375,"pubTatorScore":1.0089379385191353,"self":"https://pharos.nih.gov/idg/api/v1/targets(5007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(5007)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(5007)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(5007)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(5007)/publications"},"_namespace":null},{"id":5008,"version":2,"created":1554893516000,"modified":1554893517000,"deprecated":false,"name":"Transcription factor GATA-5","accession":"Q9BWX5","gene":"GATA5","description":"Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9592465928185772,"antibodyCount":183,"monoclonalCount":18,"pubmedCount":null,"jensenScore":86.106987,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.295975573635822,"pubTatorScore":1.7371123385263005,"self":"https://pharos.nih.gov/idg/api/v1/targets(5008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(5008)/properties"},"_links":{"count":641,"href":"https://pharos.nih.gov/idg/api/v1/targets(5008)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(5008)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(5008)/publications"},"_namespace":null},{"id":5009,"version":3,"created":1554893518000,"modified":1555035991000,"deprecated":false,"name":"Group XIIB secretory phospholipase A2-like protein","accession":"Q9BX93","gene":"PLA2G12B","description":"Not known; does not seem to have catalytic activity.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4680568404522591,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.94339,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":21.074505562234954,"pubTatorScore":0.3000889464395743,"self":"https://pharos.nih.gov/idg/api/v1/targets(5009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(5009)/properties"},"_links":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(5009)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(5009)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(5009)/publications"},"_namespace":null},{"id":5010,"version":2,"created":1554893519000,"modified":1554893522000,"deprecated":false,"name":"E3 ubiquitin-protein ligase listerin","accession":"O94822","gene":"LTN1","description":"E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4697518787401709,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":30.082142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.46968160405547,"pubTatorScore":0.8445806733703959,"self":"https://pharos.nih.gov/idg/api/v1/targets(5010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(5010)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(5010)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(5010)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(5010)/publications"},"_namespace":null},{"id":5011,"version":2,"created":1554893523000,"modified":1554893523000,"deprecated":false,"name":"Putative uncharacterized protein C20orf204","accession":"Q6ZNR8","gene":"C20orf204","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(5011)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5011)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(5011)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(5011)/publications"},"_namespace":null},{"id":5012,"version":2,"created":1554893523000,"modified":1554893525000,"deprecated":false,"name":"Probable phospholipid-transporting ATPase VB","accession":"O94823","gene":"ATP10B","description":"Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).","idgFamily":"Transporter","idgTDL":"Tdark","novelty":0.4835719858574127,"antibodyCount":10,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.34787,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.41252108188576,"pubTatorScore":-0.24243544905621783,"self":"https://pharos.nih.gov/idg/api/v1/targets(5012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(5012)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(5012)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(5012)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5012)/publications"},"_namespace":null},{"id":5013,"version":3,"created":1554893526000,"modified":1555035991000,"deprecated":false,"name":"Plasmalemma vesicle-associated protein","accession":"Q9BX97","gene":"PLVAP","description":"Involved in the formation of stomatal and fenestral diaphragms of caveolae. 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Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3853400241376843,"antibodyCount":135,"monoclonalCount":10,"pubmedCount":null,"jensenScore":27.210803,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.630356414218696,"pubTatorScore":1.31251873177626,"self":"https://pharos.nih.gov/idg/api/v1/targets(5014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":431,"href":"https://pharos.nih.gov/idg/api/v1/targets(5014)/properties"},"_links":{"count":1185,"href":"https://pharos.nih.gov/idg/api/v1/targets(5014)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(5014)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(5014)/publications"},"_namespace":null},{"id":5015,"version":3,"created":1554893533000,"modified":1555035994000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(s) subunit alpha isoforms short","accession":"P63092","gene":"GNAS","description":"Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6335564959942657,"antibodyCount":509,"monoclonalCount":63,"pubmedCount":null,"jensenScore":1389.742966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":64.70415849103543,"pubTatorScore":3.128609119577192,"self":"https://pharos.nih.gov/idg/api/v1/targets(5015)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(5015)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(5015)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(5015)/synonyms"},"_publications":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(5015)/publications"},"_namespace":null},{"id":5016,"version":2,"created":1554893538000,"modified":1554893541000,"deprecated":false,"name":"Triokinase/FMN cyclase","accession":"Q3LXA3","gene":"TKFC","description":"Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. 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Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.315237198046086,"antibodyCount":245,"monoclonalCount":65,"pubmedCount":null,"jensenScore":216.345457,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.45159090753348,"pubTatorScore":1.848431127141194,"self":"https://pharos.nih.gov/idg/api/v1/targets(5055)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(5055)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(5055)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(5055)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(5055)/publications"},"_namespace":null},{"id":5056,"version":2,"created":1554893651000,"modified":1554893655000,"deprecated":false,"name":"Leucine-rich repeat transmembrane protein FLRT3","accession":"Q9NZU0","gene":"FLRT3","description":"Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. 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Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.293350737502221,"antibodyCount":58,"monoclonalCount":5,"pubmedCount":null,"jensenScore":20.631789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.40855510184722,"pubTatorScore":0.9522250689459894,"self":"https://pharos.nih.gov/idg/api/v1/targets(5056)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(5056)/properties"},"_links":{"count":1044,"href":"https://pharos.nih.gov/idg/api/v1/targets(5056)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(5056)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5056)/publications"},"_namespace":null},{"id":5057,"version":3,"created":1554893656000,"modified":1555036032000,"deprecated":false,"name":"Leucine-rich repeat transmembrane protein FLRT1","accession":"Q9NZU1","gene":"FLRT1","description":"Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. 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Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0215579804417663,"antibodyCount":235,"monoclonalCount":62,"pubmedCount":null,"jensenScore":10.871867,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.32710724678933,"pubTatorScore":0.9585486898159157,"self":"https://pharos.nih.gov/idg/api/v1/targets(5058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(5058)/publications"},"_namespace":null},{"id":5059,"version":3,"created":1554893663000,"modified":1555036033000,"deprecated":false,"name":"LIM and cysteine-rich domains protein 1","accession":"Q9NZU5","gene":"LMCD1","description":"Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0017226535539725,"antibodyCount":67,"monoclonalCount":26,"pubmedCount":null,"jensenScore":10.931751,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.2234284162914,"pubTatorScore":0.8097146190377389,"self":"https://pharos.nih.gov/idg/api/v1/targets(5059)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(5059)/publications"},"_namespace":null},{"id":5060,"version":3,"created":1554893666000,"modified":1555036034000,"deprecated":false,"name":"Calcium-binding protein 1","accession":"Q9NZU7","gene":"CABP1","description":"Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4626712420394332,"antibodyCount":100,"monoclonalCount":8,"pubmedCount":null,"jensenScore":34.879268,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.489805885231114,"pubTatorScore":1.5685889889801956,"self":"https://pharos.nih.gov/idg/api/v1/targets(5060)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(5060)/publications"},"_namespace":null},{"id":5061,"version":2,"created":1554893670000,"modified":1554893672000,"deprecated":false,"name":"Caspase recruitment domain-containing protein 6","accession":"Q9BX69","gene":"CARD6","description":"May be involved in apoptosis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8631185834738431,"antibodyCount":239,"monoclonalCount":22,"pubmedCount":null,"jensenScore":8.434526,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.58819885928487,"pubTatorScore":0.7994029317200615,"self":"https://pharos.nih.gov/idg/api/v1/targets(5061)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(5061)/publications"},"_namespace":null},{"id":5062,"version":3,"created":1554893673000,"modified":1555036037000,"deprecated":false,"name":"Histidine triad nucleotide-binding protein 2, mitochondrial","accession":"Q9BX68","gene":"HINT2","description":"Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3941596899091702,"antibodyCount":84,"monoclonalCount":24,"pubmedCount":null,"jensenScore":24.203967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":28.380999057146745,"pubTatorScore":0.920384190010849,"self":"https://pharos.nih.gov/idg/api/v1/targets(5062)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5062)/publications"},"_namespace":null},{"id":5063,"version":2,"created":1554893676000,"modified":1554893679000,"deprecated":false,"name":"[F-actin]-monooxygenase MICAL2","accession":"O94851","gene":"MICAL2","description":"Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4764922657148974,"antibodyCount":57,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.616452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.01591435561061,"pubTatorScore":0.672977014428254,"self":"https://pharos.nih.gov/idg/api/v1/targets(5063)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(5063)/publications"},"_namespace":null},{"id":5064,"version":2,"created":1554893679000,"modified":1554893683000,"deprecated":false,"name":"Fanconi anemia group J protein","accession":"Q9BX63","gene":"BRIP1","description":"DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8187465390023196,"antibodyCount":223,"monoclonalCount":53,"pubmedCount":null,"jensenScore":78.300437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.42470307810724,"pubTatorScore":2.0474962504997256,"self":"https://pharos.nih.gov/idg/api/v1/targets(5064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":539,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/synonyms"},"_publications":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(5064)/publications"},"_namespace":null},{"id":5065,"version":2,"created":1554893684000,"modified":1554893686000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 69","accession":"Q6ZNQ3","gene":"LRRC69","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.006958345326943,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/properties"},"_links":{"count":751,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5065)/publications"},"_namespace":null},{"id":5066,"version":3,"created":1554893687000,"modified":1555036039000,"deprecated":false,"name":"Cyclin-dependent kinase 19","accession":"Q9BWU1","gene":"CDK19","description":null,"idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.3539977159874228,"antibodyCount":154,"monoclonalCount":22,"pubmedCount":null,"jensenScore":17.997991,"patentCount":3925,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":41.6724391788971,"pubTatorScore":1.3005492044997105,"self":"https://pharos.nih.gov/idg/api/v1/targets(5066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(5066)/publications"},"_namespace":null},{"id":5067,"version":2,"created":1554893692000,"modified":1554893695000,"deprecated":false,"name":"Kanadaptin","accession":"Q9BWU0","gene":"SLC4A1AP","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.4648868019217715,"antibodyCount":86,"monoclonalCount":9,"pubmedCount":null,"jensenScore":3.431047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.02679040728838,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(5067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(5067)/publications"},"_namespace":null},{"id":5068,"version":2,"created":1554893695000,"modified":1554893697000,"deprecated":false,"name":"Dendrin","accession":"O94850","gene":"DDN","description":"Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1131259112908065,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":132.846781,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.743918802617294,"pubTatorScore":0.8940924875140192,"self":"https://pharos.nih.gov/idg/api/v1/targets(5068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(5068)/publications"},"_namespace":null},{"id":5069,"version":3,"created":1554893698000,"modified":1555036041000,"deprecated":false,"name":"Protein transport protein Sec24D","accession":"O94855","gene":"SEC24D","description":"Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.083827986902072,"antibodyCount":66,"monoclonalCount":43,"pubmedCount":null,"jensenScore":8.632333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.162547016727785,"pubTatorScore":0.851955595960691,"self":"https://pharos.nih.gov/idg/api/v1/targets(5069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(5069)/publications"},"_namespace":null},{"id":5070,"version":3,"created":1554893703000,"modified":1555036042000,"deprecated":false,"name":"Junctional adhesion molecule C","accession":"Q9BX67","gene":"JAM3","description":"Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9375658138457388,"antibodyCount":251,"monoclonalCount":112,"pubmedCount":null,"jensenScore":97.088243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.235803814919635,"pubTatorScore":1.7322243599839693,"self":"https://pharos.nih.gov/idg/api/v1/targets(5070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(5070)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(5070)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(5070)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(5070)/publications"},"_namespace":null},{"id":5071,"version":2,"created":1554893707000,"modified":1554893711000,"deprecated":false,"name":"Sorbin and SH3 domain-containing protein 1","accession":"Q9BX66","gene":"SORBS1","description":"Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5734116460084546,"antibodyCount":224,"monoclonalCount":2,"pubmedCount":null,"jensenScore":40.205135,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.59284993002824,"pubTatorScore":1.4129281576000365,"self":"https://pharos.nih.gov/idg/api/v1/targets(5071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":475,"href":"https://pharos.nih.gov/idg/api/v1/targets(5071)/properties"},"_links":{"count":1309,"href":"https://pharos.nih.gov/idg/api/v1/targets(5071)/links"},"_synonyms":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(5071)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(5071)/publications"},"_namespace":null},{"id":5072,"version":2,"created":1554893712000,"modified":1554893716000,"deprecated":false,"name":"Neurofascin","accession":"O94856","gene":"NFASC","description":"Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.095403996801651,"antibodyCount":154,"monoclonalCount":9,"pubmedCount":null,"jensenScore":119.24203,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.71273940405367,"pubTatorScore":1.8512389273696153,"self":"https://pharos.nih.gov/idg/api/v1/targets(5072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(5072)/properties"},"_links":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(5072)/links"},"_synonyms":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(5072)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(5072)/publications"},"_namespace":null},{"id":5073,"version":2,"created":1554893717000,"modified":1554893717000,"deprecated":false,"name":"Uncharacterized protein KIAA0754","accession":"O94854","gene":"KIAA0754","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.1785658783069157,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.097619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.376798022867348,"pubTatorScore":-0.9892761346082269,"self":"https://pharos.nih.gov/idg/api/v1/targets(5073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(5073)/properties"},"_links":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(5073)/links"},"_synonyms":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(5073)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(5073)/publications"},"_namespace":null},{"id":5074,"version":3,"created":1554893717000,"modified":1555036044000,"deprecated":false,"name":"Chymotrypsin-like elastase family member 1","accession":"Q9UNI1","gene":"CELA1","description":"Acts upon elastin.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.4267465259390093,"antibodyCount":108,"monoclonalCount":19,"pubmedCount":null,"jensenScore":259.778355,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":23.115190309423962,"pubTatorScore":2.329852501229747,"self":"https://pharos.nih.gov/idg/api/v1/targets(5074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":162,"href":"https://pharos.nih.gov/idg/api/v1/targets(5074)/properties"},"_links":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(5074)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(5074)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(5074)/publications"},"_namespace":null},{"id":5075,"version":3,"created":1554893723000,"modified":1555036045000,"deprecated":false,"name":"Histone-binding protein RBBP4","accession":"Q09028","gene":"RBBP4","description":"Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7120944099950182,"antibodyCount":310,"monoclonalCount":128,"pubmedCount":null,"jensenScore":53.878462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":50.707516475195575,"pubTatorScore":2.6699442180619437,"self":"https://pharos.nih.gov/idg/api/v1/targets(5075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(5075)/properties"},"_links":{"count":1252,"href":"https://pharos.nih.gov/idg/api/v1/targets(5075)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(5075)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(5075)/publications"},"_namespace":null},{"id":5076,"version":2,"created":1554893728000,"modified":1554893730000,"deprecated":false,"name":"Dual specificity protein phosphatase 12","accession":"Q9UNI6","gene":"DUSP12","description":"Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7805181659240796,"antibodyCount":167,"monoclonalCount":10,"pubmedCount":null,"jensenScore":60.206961,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.95973534425031,"pubTatorScore":1.2281439671554135,"self":"https://pharos.nih.gov/idg/api/v1/targets(5076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(5076)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(5076)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(5076)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(5076)/publications"},"_namespace":null},{"id":5077,"version":2,"created":1554893730000,"modified":1554893733000,"deprecated":false,"name":"Cysteine-rich motor neuron 1 protein","accession":"Q9NZV1","gene":"CRIM1","description":"May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4713323837730687,"antibodyCount":120,"monoclonalCount":58,"pubmedCount":null,"jensenScore":33.2878,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.94753713885232,"pubTatorScore":1.264404054883989,"self":"https://pharos.nih.gov/idg/api/v1/targets(5077)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(5077)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(5077)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(5077)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(5077)/publications"},"_namespace":null},{"id":5078,"version":2,"created":1554893734000,"modified":1554893737000,"deprecated":false,"name":"Selenoprotein N","accession":"Q9NZV5","gene":"SELENON","description":"Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.953838976821862,"antibodyCount":96,"monoclonalCount":0,"pubmedCount":null,"jensenScore":87.612047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.7615922877182704,"self":"https://pharos.nih.gov/idg/api/v1/targets(5078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(5078)/properties"},"_links":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(5078)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(5078)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(5078)/publications"},"_namespace":null},{"id":5079,"version":2,"created":1554893737000,"modified":1554893740000,"deprecated":false,"name":"Methionine-R-sulfoxide reductase B1","accession":"Q9NZV6","gene":"MSRB1","description":"Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5603338960207513,"antibodyCount":64,"monoclonalCount":10,"pubmedCount":null,"jensenScore":39.849067,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.43491626711909,"pubTatorScore":1.4247034577132625,"self":"https://pharos.nih.gov/idg/api/v1/targets(5079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(5079)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(5079)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(5079)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(5079)/publications"},"_namespace":null},{"id":5080,"version":3,"created":1554893740000,"modified":1555036047000,"deprecated":false,"name":"Zinc finger imprinted 2","accession":"Q9NZV7","gene":"ZIM2","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.6836875149434931,"antibodyCount":68,"monoclonalCount":44,"pubmedCount":null,"jensenScore":3.418077,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":21.622812227912437,"pubTatorScore":0.5678521524237999,"self":"https://pharos.nih.gov/idg/api/v1/targets(5080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(5080)/properties"},"_links":{"count":598,"href":"https://pharos.nih.gov/idg/api/v1/targets(5080)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(5080)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(5080)/publications"},"_namespace":null},{"id":5081,"version":2,"created":1554893742000,"modified":1554893745000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase FKBP3","accession":"Q00688","gene":"FKBP3","description":"FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9688501694594644,"antibodyCount":161,"monoclonalCount":15,"pubmedCount":null,"jensenScore":93.517634,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.96271076538748,"pubTatorScore":1.5487646289484718,"self":"https://pharos.nih.gov/idg/api/v1/targets(5081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(5081)/properties"},"_links":{"count":1079,"href":"https://pharos.nih.gov/idg/api/v1/targets(5081)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(5081)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(5081)/publications"},"_namespace":null},{"id":5082,"version":3,"created":1554893746000,"modified":1555036048000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily D member 2","accession":"Q9NZV8","gene":"KCND2","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.3930868423726737,"antibodyCount":317,"monoclonalCount":70,"pubmedCount":null,"jensenScore":245.676512,"patentCount":4501,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":40.94675951472341,"pubTatorScore":2.042465743730772,"self":"https://pharos.nih.gov/idg/api/v1/targets(5082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(5082)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(5082)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(5082)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(5082)/publications"},"_namespace":null},{"id":5083,"version":2,"created":1554893752000,"modified":1554893754000,"deprecated":false,"name":"Tapasin-related protein","accession":"Q9BX59","gene":"TAPBPL","description":"Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). 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Modulates the hepatic lipid metabolism (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6338973246051018,"antibodyCount":127,"monoclonalCount":4,"pubmedCount":null,"jensenScore":38.595703,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":35.20159009140493,"pubTatorScore":1.4298940887073404,"self":"https://pharos.nih.gov/idg/api/v1/targets(5087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(5087)/publications"},"_namespace":null},{"id":5088,"version":3,"created":1554893767000,"modified":1555036052000,"deprecated":false,"name":"RUN and FYVE domain-containing protein 4","accession":"Q6ZNE9","gene":"RUFY4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.155556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":17.79281835496501,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(5088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/properties"},"_links":{"count":702,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5088)/publications"},"_namespace":null},{"id":5089,"version":2,"created":1554893769000,"modified":1554893772000,"deprecated":false,"name":"F-BAR and double SH3 domains protein 2","accession":"O94868","gene":"FCHSD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5611743842633938,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.287071,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.376264789324104,"pubTatorScore":0.66266425946456,"self":"https://pharos.nih.gov/idg/api/v1/targets(5089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(5089)/publications"},"_namespace":null},{"id":5090,"version":2,"created":1554893772000,"modified":1554893775000,"deprecated":false,"name":"Cell cycle regulator of non-homologous end joining","accession":"Q9BWK5","gene":"C7orf49","description":"Isoform 4: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:24610814, PubMed:28959974). 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Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2072094331412355,"antibodyCount":85,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.549016,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.318046806800005,"pubTatorScore":1.1563471907600522,"self":"https://pharos.nih.gov/idg/api/v1/targets(5091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(5091)/publications"},"_namespace":null},{"id":5092,"version":3,"created":1554893779000,"modified":1555036052000,"deprecated":false,"name":"Actin-binding LIM protein 2","accession":"Q6H8Q1","gene":"ABLIM2","description":"May act as scaffold protein. 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Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4865261618626135,"antibodyCount":82,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.56487,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.66347102180186,"pubTatorScore":1.3786970431520642,"self":"https://pharos.nih.gov/idg/api/v1/targets(5093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/properties"},"_links":{"count":1271,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(5093)/publications"},"_namespace":null},{"id":5094,"version":2,"created":1554893787000,"modified":1554893790000,"deprecated":false,"name":"Transmembrane and coiled-coil domains protein 1","accession":"O94876","gene":"TMCC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8028551283922968,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.64154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.214987167519446,"pubTatorScore":0.8372727025023002,"self":"https://pharos.nih.gov/idg/api/v1/targets(5094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5094)/publications"},"_namespace":null},{"id":5095,"version":2,"created":1554893790000,"modified":1554893793000,"deprecated":false,"name":"Splicing factor 3B subunit 5","accession":"Q9BWJ5","gene":"SF3B5","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). 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AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). 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Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1 (PubMed:27824081).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3513167795160543,"antibodyCount":155,"monoclonalCount":25,"pubmedCount":null,"jensenScore":27.063622,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":61,"knowledgeAvailability":0.0,"pubTatorScore":1.5647466675077986,"self":"https://pharos.nih.gov/idg/api/v1/targets(5163)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(5163)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(5163)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(5163)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(5163)/publications"},"_namespace":null},{"id":5164,"version":3,"created":1554893998000,"modified":1555036104000,"deprecated":false,"name":"Vesicle-associated membrane protein 2","accession":"P63027","gene":"VAMP2","description":"Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5333458737695436,"antibodyCount":203,"monoclonalCount":73,"pubmedCount":null,"jensenScore":323.709802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":42.07564012705895,"pubTatorScore":2.301746483137229,"self":"https://pharos.nih.gov/idg/api/v1/targets(5164)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(5164)/properties"},"_links":{"count":1140,"href":"https://pharos.nih.gov/idg/api/v1/targets(5164)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(5164)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(5164)/publications"},"_namespace":null},{"id":5165,"version":3,"created":1554894003000,"modified":1555036106000,"deprecated":false,"name":"Polycystic kidney disease 2-like 2 protein","accession":"Q9NZM6","gene":"PKD2L2","description":"May function as a subunit of a cation channel and play a role in fertilization.","idgFamily":"Ion Channel","idgTDL":"Tdark","novelty":-0.6767331897702848,"antibodyCount":77,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.794022,"patentCount":647,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":26.63487003273827,"pubTatorScore":0.4759129605838403,"self":"https://pharos.nih.gov/idg/api/v1/targets(5165)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(5165)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(5165)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(5165)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(5165)/publications"},"_namespace":null},{"id":5166,"version":3,"created":1554894006000,"modified":1555036108000,"deprecated":false,"name":"Zinc finger protein 416","accession":"Q9BWM5","gene":"ZNF416","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":78,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":21.485582038362107,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5166)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(5166)/properties"},"_links":{"count":764,"href":"https://pharos.nih.gov/idg/api/v1/targets(5166)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(5166)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5166)/publications"},"_namespace":null},{"id":5167,"version":2,"created":1554894008000,"modified":1554894009000,"deprecated":false,"name":"Homeobox protein DBX2","accession":"Q6ZNG2","gene":"DBX2","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.7110033446050259,"antibodyCount":109,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.948822,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.079028451486751,"pubTatorScore":-0.062148240821651324,"self":"https://pharos.nih.gov/idg/api/v1/targets(5167)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(5167)/properties"},"_links":{"count":570,"href":"https://pharos.nih.gov/idg/api/v1/targets(5167)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(5167)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(5167)/publications"},"_namespace":null},{"id":5168,"version":3,"created":1554894010000,"modified":1555036108000,"deprecated":false,"name":"Alpha-1,4-N-acetylglucosaminyltransferase","accession":"Q9UNA3","gene":"A4GNT","description":"Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.006635819862815,"antibodyCount":235,"monoclonalCount":73,"pubmedCount":null,"jensenScore":3.505739,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":19.272837003713462,"pubTatorScore":0.9151987361722592,"self":"https://pharos.nih.gov/idg/api/v1/targets(5168)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(5168)/publications"},"_namespace":null},{"id":5169,"version":3,"created":1554894012000,"modified":1555036109000,"deprecated":false,"name":"Rho GTPase-activating protein 26","accession":"Q9UNA1","gene":"ARHGAP26","description":"GTPase-activating protein for RHOA and CDC42.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7133636968188473,"antibodyCount":219,"monoclonalCount":6,"pubmedCount":null,"jensenScore":51.869935,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":41.32284786762476,"pubTatorScore":2.5224965035052187,"self":"https://pharos.nih.gov/idg/api/v1/targets(5169)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(5169)/publications"},"_namespace":null},{"id":5170,"version":3,"created":1554894016000,"modified":1554894090000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 5","accession":"Q9UNA0","gene":"ADAMTS5","description":"Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.2625107702356306,"antibodyCount":371,"monoclonalCount":6,"pubmedCount":null,"jensenScore":168.435894,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.911857993285324,"pubTatorScore":2.0876664422874893,"self":"https://pharos.nih.gov/idg/api/v1/targets(5170)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/properties"},"_links":{"count":1171,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(5170)/publications"},"_namespace":null},{"id":5171,"version":2,"created":1554894092000,"modified":1554894095000,"deprecated":false,"name":"Interleukin-1 receptor accessory protein-like 1","accession":"Q9NZN1","gene":"IL1RAPL1","description":"May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8176955045504732,"antibodyCount":132,"monoclonalCount":82,"pubmedCount":null,"jensenScore":63.928496,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.05943053816925,"pubTatorScore":1.644171086087882,"self":"https://pharos.nih.gov/idg/api/v1/targets(5171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(5171)/publications"},"_namespace":null},{"id":5172,"version":2,"created":1554894095000,"modified":1554894099000,"deprecated":false,"name":"DNA polymerase iota","accession":"Q9UNA4","gene":"POLI","description":"Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.2400754309886093,"antibodyCount":333,"monoclonalCount":147,"pubmedCount":null,"jensenScore":1701.877752,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.754109382814946,"pubTatorScore":2.7761418746432684,"self":"https://pharos.nih.gov/idg/api/v1/targets(5172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/links"},"_synonyms":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(5172)/publications"},"_namespace":null},{"id":5173,"version":3,"created":1554894100000,"modified":1555036111000,"deprecated":false,"name":"EH domain-containing protein 3","accession":"Q9NZN3","gene":"EHD3","description":"ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6966106057389705,"antibodyCount":89,"monoclonalCount":26,"pubmedCount":null,"jensenScore":55.775501,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.58161730507622,"pubTatorScore":1.9698717242169155,"self":"https://pharos.nih.gov/idg/api/v1/targets(5173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(5173)/publications"},"_namespace":null},{"id":5174,"version":3,"created":1554894104000,"modified":1555036112000,"deprecated":false,"name":"EH domain-containing protein 2","accession":"Q9NZN4","gene":"EHD2","description":"ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4997228977553096,"antibodyCount":144,"monoclonalCount":54,"pubmedCount":null,"jensenScore":32.196997,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.730140699427345,"pubTatorScore":2.696469937089102,"self":"https://pharos.nih.gov/idg/api/v1/targets(5174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(5174)/publications"},"_namespace":null},{"id":5175,"version":2,"created":1554894107000,"modified":1554894111000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 12","accession":"Q9NZN5","gene":"ARHGEF12","description":"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). 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Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. 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SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.571500746036807,"antibodyCount":381,"monoclonalCount":103,"pubmedCount":null,"jensenScore":310.07091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":95,"knowledgeAvailability":47.93786258007545,"pubTatorScore":2.2656441219600394,"self":"https://pharos.nih.gov/idg/api/v1/targets(5193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":644,"href":"https://pharos.nih.gov/idg/api/v1/targets(5193)/properties"},"_links":{"count":1195,"href":"https://pharos.nih.gov/idg/api/v1/targets(5193)/links"},"_synonyms":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(5193)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(5193)/publications"},"_namespace":null},{"id":5194,"version":2,"created":1554894165000,"modified":1554894169000,"deprecated":false,"name":"Targeting protein for Xklp2","accession":"Q9ULW0","gene":"TPX2","description":"Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.211478112777527,"antibodyCount":435,"monoclonalCount":163,"pubmedCount":null,"jensenScore":180.010379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.05003399558049,"pubTatorScore":2.0173007406022525,"self":"https://pharos.nih.gov/idg/api/v1/targets(5194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(5194)/properties"},"_links":{"count":1157,"href":"https://pharos.nih.gov/idg/api/v1/targets(5194)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(5194)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(5194)/publications"},"_namespace":null},{"id":5195,"version":2,"created":1554894170000,"modified":1554894172000,"deprecated":false,"name":"Nucleosome assembly protein 1-like 2","accession":"Q9ULW6","gene":"NAP1L2","description":"Acidic protein which may be involved in interactions with other proteins or DNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9905661023610335,"antibodyCount":108,"monoclonalCount":3,"pubmedCount":null,"jensenScore":94.626053,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.83065527039389,"pubTatorScore":0.8619988038133581,"self":"https://pharos.nih.gov/idg/api/v1/targets(5195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(5195)/properties"},"_links":{"count":832,"href":"https://pharos.nih.gov/idg/api/v1/targets(5195)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(5195)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(5195)/publications"},"_namespace":null},{"id":5196,"version":2,"created":1554894173000,"modified":1554894175000,"deprecated":false,"name":"OTU domain-containing protein 4","accession":"Q01804","gene":"OTUD4","description":"Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4586378452255726,"antibodyCount":138,"monoclonalCount":19,"pubmedCount":null,"jensenScore":3.05636,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.29002447821258,"pubTatorScore":1.7028391927361157,"self":"https://pharos.nih.gov/idg/api/v1/targets(5196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(5196)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(5196)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(5196)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(5196)/publications"},"_namespace":null},{"id":5197,"version":3,"created":1554894176000,"modified":1555036128000,"deprecated":false,"name":"Ras-related protein Rab-26","accession":"Q9ULW5","gene":"RAB26","description":"The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6214108335473534,"antibodyCount":119,"monoclonalCount":11,"pubmedCount":null,"jensenScore":6.102459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":31.209224642844994,"pubTatorScore":0.8244020146708736,"self":"https://pharos.nih.gov/idg/api/v1/targets(5197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(5197)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(5197)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(5197)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(5197)/publications"},"_namespace":null},{"id":5198,"version":3,"created":1554894179000,"modified":1555036131000,"deprecated":false,"name":"Dual specificity mitogen-activated protein kinase kinase 6","accession":"P52564","gene":"MAP2K6","description":"Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.017634227723217,"antibodyCount":636,"monoclonalCount":105,"pubmedCount":null,"jensenScore":74.404208,"patentCount":18365,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":51.55007519543338,"pubTatorScore":1.9792391963227534,"self":"https://pharos.nih.gov/idg/api/v1/targets(5198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":617,"href":"https://pharos.nih.gov/idg/api/v1/targets(5198)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(5198)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(5198)/synonyms"},"_publications":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(5198)/publications"},"_namespace":null},{"id":5199,"version":2,"created":1554894184000,"modified":1554894190000,"deprecated":false,"name":"Rho GDP-dissociation inhibitor 1","accession":"P52565","gene":"ARHGDIA","description":"Controls Rho proteins homeostasis. 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In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.568850218793339,"antibodyCount":382,"monoclonalCount":90,"pubmedCount":null,"jensenScore":370.130165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.68886642323715,"pubTatorScore":2.206501436704783,"self":"https://pharos.nih.gov/idg/api/v1/targets(5199)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":534,"href":"https://pharos.nih.gov/idg/api/v1/targets(5199)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(5199)/links"},"_synonyms":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(5199)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(5199)/publications"},"_namespace":null},{"id":5200,"version":3,"created":1554894192000,"modified":1555036134000,"deprecated":false,"name":"Protein-arginine deiminase type-3","accession":"Q9ULW8","gene":"PADI3","description":"Catalyzes the deimination of arginine residues of proteins.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.6486474874504546,"antibodyCount":53,"monoclonalCount":5,"pubmedCount":null,"jensenScore":41.70876,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":25.620043797427567,"pubTatorScore":1.451274587294257,"self":"https://pharos.nih.gov/idg/api/v1/targets(5200)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(5200)/properties"},"_links":{"count":489,"href":"https://pharos.nih.gov/idg/api/v1/targets(5200)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(5200)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(5200)/publications"},"_namespace":null},{"id":5201,"version":2,"created":1554894195000,"modified":1554894196000,"deprecated":false,"name":"Protein canopy homolog 1","accession":"Q3B7I2","gene":"CNPY1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.15461614558946488,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.811608,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.86300278175069,"pubTatorScore":-0.38021089427615945,"self":"https://pharos.nih.gov/idg/api/v1/targets(5201)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(5201)/properties"},"_links":{"count":514,"href":"https://pharos.nih.gov/idg/api/v1/targets(5201)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(5201)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5201)/publications"},"_namespace":null},{"id":5202,"version":2,"created":1554894197000,"modified":1554894199000,"deprecated":false,"name":"Cationic amino acid transporter 2","accession":"P52569","gene":"SLC7A2","description":"Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. 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May play a role in classical or alternative activation of macrophages via its role in arginine transport.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.5586757043704151,"antibodyCount":57,"monoclonalCount":2,"pubmedCount":null,"jensenScore":37.614423,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.35111347622276,"pubTatorScore":1.9835296808093572,"self":"https://pharos.nih.gov/idg/api/v1/targets(5202)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(5202)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(5202)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(5202)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(5202)/publications"},"_namespace":null},{"id":5203,"version":2,"created":1554894200000,"modified":1554894203000,"deprecated":false,"name":"Rho GDP-dissociation inhibitor 2","accession":"P52566","gene":"ARHGDIB","description":"Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). 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May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.7169137097662435,"antibodyCount":214,"monoclonalCount":35,"pubmedCount":null,"jensenScore":609.594295,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":25.360404757976855,"pubTatorScore":2.4853519643628177,"self":"https://pharos.nih.gov/idg/api/v1/targets(5237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/synonyms"},"_publications":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(5237)/publications"},"_namespace":null},{"id":5238,"version":2,"created":1554894404000,"modified":1554894407000,"deprecated":false,"name":"TP53-target gene 3 protein","accession":"Q9ULZ0","gene":"TP53TG3B","description":"May play a significant role in p53/TP53-mediating signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.546781442977668,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(5238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/links"},"_synonyms":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5238)/publications"},"_namespace":null},{"id":5239,"version":3,"created":1554894407000,"modified":1555036154000,"deprecated":false,"name":"Protein FAM90A1","accession":"Q86YD7","gene":"FAM90A1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":21.259142963268093,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/properties"},"_links":{"count":715,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(5239)/publications"},"_namespace":null},{"id":5240,"version":3,"created":1554894409000,"modified":1555036155000,"deprecated":false,"name":"Apoptosis-associated speck-like protein containing a CARD","accession":"Q9ULZ3","gene":"PYCARD","description":"Functions as key mediator in apoptosis and inflammation. 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Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating MB21D1 in presence of cytoplasmic double-stranded DNA (PubMed:28314590).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.867437434852167,"antibodyCount":477,"monoclonalCount":75,"pubmedCount":null,"jensenScore":55.85018,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.81590342721578,"pubTatorScore":2.817654279774482,"self":"https://pharos.nih.gov/idg/api/v1/targets(5240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":564,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/properties"},"_links":{"count":1233,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/synonyms"},"_publications":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(5240)/publications"},"_namespace":null},{"id":5241,"version":2,"created":1554894415000,"modified":1554894417000,"deprecated":false,"name":"Low-density lipoprotein receptor class A domain-containing protein 3","accession":"Q86YD5","gene":"LDLRAD3","description":"May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3357921033708414,"antibodyCount":114,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.34113,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.804706514122163,"pubTatorScore":-0.1760916933503803,"self":"https://pharos.nih.gov/idg/api/v1/targets(5241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(5241)/publications"},"_namespace":null},{"id":5242,"version":2,"created":1554894418000,"modified":1554894421000,"deprecated":false,"name":"Matrix metalloproteinase-17","accession":"Q9ULZ9","gene":"MMP17","description":"Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.4082348510901432,"antibodyCount":217,"monoclonalCount":23,"pubmedCount":null,"jensenScore":27.231643,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.899791006654425,"pubTatorScore":1.4297023736315777,"self":"https://pharos.nih.gov/idg/api/v1/targets(5242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(5242)/publications"},"_namespace":null},{"id":5243,"version":3,"created":1554894422000,"modified":1555036159000,"deprecated":false,"name":"Transmembrane protein 25","accession":"Q86YD3","gene":"TMEM25","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2369124994584635,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.401338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":27.605170655899876,"pubTatorScore":0.4602910598139417,"self":"https://pharos.nih.gov/idg/api/v1/targets(5243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(5243)/publications"},"_namespace":null},{"id":5244,"version":2,"created":1554894425000,"modified":1554894427000,"deprecated":false,"name":"Polyadenylate-binding protein-interacting protein 2B","accession":"Q9ULR5","gene":"PAIP2B","description":"Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.06219385920640945,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.120132,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.26988206115168,"pubTatorScore":0.2716202225045699,"self":"https://pharos.nih.gov/idg/api/v1/targets(5244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5244)/publications"},"_namespace":null},{"id":5245,"version":2,"created":1554894428000,"modified":1554894431000,"deprecated":false,"name":"Protein phosphatase 1H","accession":"Q9ULR3","gene":"PPM1H","description":"Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9607424930417306,"antibodyCount":113,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.718903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.14364960843379,"pubTatorScore":0.9387459696850307,"self":"https://pharos.nih.gov/idg/api/v1/targets(5245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(5245)/publications"},"_namespace":null},{"id":5246,"version":2,"created":1554894431000,"modified":1554894434000,"deprecated":false,"name":"Plakophilin-1","accession":"Q13835","gene":"PKP1","description":"Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8606234752760704,"antibodyCount":103,"monoclonalCount":53,"pubmedCount":null,"jensenScore":76.252326,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.22855959596442,"pubTatorScore":1.9385627922449553,"self":"https://pharos.nih.gov/idg/api/v1/targets(5246)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(5246)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(5246)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(5246)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(5246)/publications"},"_namespace":null},{"id":5247,"version":2,"created":1554894435000,"modified":1554894436000,"deprecated":false,"name":"Immunoglobulin lambda variable 1-36","accession":"A0A0B4J1U3","gene":"IGLV1-36","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.867566595383972,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5247)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(5247)/properties"},"_links":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(5247)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(5247)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(5247)/publications"},"_namespace":null},{"id":5248,"version":2,"created":1554894436000,"modified":1554894438000,"deprecated":false,"name":"Ceramide-1-phosphate transfer protein","accession":"Q5TA50","gene":"CPTP","description":"Mediates the intracellular transfer of ceramide-1-phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.596649518134188,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":40.18907,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.878019214028242,"pubTatorScore":0.9251400933354534,"self":"https://pharos.nih.gov/idg/api/v1/targets(5248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(5248)/publications"},"_namespace":null},{"id":5249,"version":2,"created":1554894439000,"modified":1554894439000,"deprecated":false,"name":"Putative mucosal pentraxin homolog","accession":"A8MV57","gene":"MPTX1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.5379436216774398,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(5249)/publications"},"_namespace":null},{"id":5250,"version":2,"created":1554894439000,"modified":1554894442000,"deprecated":false,"name":"Endoribonuclease ZC3H12A","accession":"Q5D1E8","gene":"ZC3H12A","description":"(Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8102753371988622,"antibodyCount":134,"monoclonalCount":3,"pubmedCount":null,"jensenScore":77.827164,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.75742570025197,"pubTatorScore":1.5803380194906538,"self":"https://pharos.nih.gov/idg/api/v1/targets(5250)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(5250)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(5250)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(5250)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(5250)/publications"},"_namespace":null},{"id":5251,"version":2,"created":1554894443000,"modified":1554894443000,"deprecated":false,"name":"Immunoglobulin heavy variable 6-1","accession":"A0A0B4J1U7","gene":"IGHV6-1","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.31479860064854,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/properties"},"_links":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(5251)/publications"},"_namespace":null},{"id":5252,"version":2,"created":1554894444000,"modified":1554894447000,"deprecated":false,"name":"Spliceosome RNA helicase DDX39B","accession":"Q13838","gene":"DDX39B","description":"Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.744936489076175,"antibodyCount":182,"monoclonalCount":67,"pubmedCount":null,"jensenScore":60.559347,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.0239042300025,"pubTatorScore":1.8135573785843255,"self":"https://pharos.nih.gov/idg/api/v1/targets(5252)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(5252)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(5252)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(5252)/synonyms"},"_publications":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(5252)/publications"},"_namespace":null},{"id":5253,"version":2,"created":1554894448000,"modified":1554894450000,"deprecated":false,"name":"Doublesex- and mab-3-related transcription factor A2","accession":"Q96SC8","gene":"DMRTA2","description":"May be involved in sexual development.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.0669911044050806,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.474891,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.614964155204383,"pubTatorScore":0.2697722760055096,"self":"https://pharos.nih.gov/idg/api/v1/targets(5253)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(5253)/properties"},"_links":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(5253)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(5253)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5253)/publications"},"_namespace":null},{"id":5254,"version":2,"created":1554894450000,"modified":1554894452000,"deprecated":false,"name":"Microtubule-associated proteins 1A/1B light chain 3 beta 2","accession":"A6NCE7","gene":"MAP1LC3B2","description":"Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). 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Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2911386546153143,"antibodyCount":179,"monoclonalCount":90,"pubmedCount":null,"jensenScore":18.904748,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.189132332480625,"pubTatorScore":1.1277485353213432,"self":"https://pharos.nih.gov/idg/api/v1/targets(5334)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(5334)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(5334)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(5334)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(5334)/publications"},"_namespace":null},{"id":5335,"version":3,"created":1554894932000,"modified":1555036213000,"deprecated":false,"name":"Chloride channel CLIC-like protein 1","accession":"Q96S66","gene":"CLCC1","description":"Seems to act as a chloride ion channel.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.7874998427088619,"antibodyCount":97,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.711447,"patentCount":1125,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":36.165714598317564,"pubTatorScore":0.6197887930319512,"self":"https://pharos.nih.gov/idg/api/v1/targets(5335)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(5335)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(5335)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(5335)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(5335)/publications"},"_namespace":null},{"id":5336,"version":2,"created":1554894936000,"modified":1554894940000,"deprecated":false,"name":"Nucleoside diphosphate kinase A","accession":"P15531","gene":"NME1","description":"Major role in the synthesis of nucleoside triphosphates other than ATP. 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Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.743696546303911,"antibodyCount":250,"monoclonalCount":37,"pubmedCount":null,"jensenScore":59.432244,"patentCount":4560,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":39.74449931094009,"pubTatorScore":1.7620843515855162,"self":"https://pharos.nih.gov/idg/api/v1/targets(5339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(5339)/properties"},"_links":{"count":922,"href":"https://pharos.nih.gov/idg/api/v1/targets(5339)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(5339)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(5339)/publications"},"_namespace":null},{"id":5340,"version":3,"created":1554894949000,"modified":1555036217000,"deprecated":false,"name":"Natriuretic peptides B","accession":"P16860","gene":"NPPB","description":"Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. 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The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4028342960214417,"antibodyCount":103,"monoclonalCount":8,"pubmedCount":null,"jensenScore":26.533695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.36560066300757,"pubTatorScore":1.2192350641071077,"self":"https://pharos.nih.gov/idg/api/v1/targets(5408)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(5408)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(5408)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(5408)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(5408)/publications"},"_namespace":null},{"id":5409,"version":3,"created":1554896316000,"modified":1555036271000,"deprecated":false,"name":"Cyclin-dependent kinase 16","accession":"Q00536","gene":"CDK16","description":"Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. 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Can phosphorylate CCNY at 'Ser-336' (in vitro).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.4787374015126604,"antibodyCount":153,"monoclonalCount":32,"pubmedCount":null,"jensenScore":34.221206,"patentCount":4108,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":44.223607867191156,"pubTatorScore":1.3281617899040792,"self":"https://pharos.nih.gov/idg/api/v1/targets(5409)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":424,"href":"https://pharos.nih.gov/idg/api/v1/targets(5409)/properties"},"_links":{"count":1131,"href":"https://pharos.nih.gov/idg/api/v1/targets(5409)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(5409)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(5409)/publications"},"_namespace":null},{"id":5410,"version":3,"created":1554896323000,"modified":1555036272000,"deprecated":false,"name":"POU domain, class 5, transcription factor 1","accession":"Q01860","gene":"POU5F1","description":"Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). 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Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.063933851621201,"antibodyCount":694,"monoclonalCount":251,"pubmedCount":null,"jensenScore":1238.432059,"patentCount":42088,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":53.60095505024111,"pubTatorScore":2.7346591353797796,"self":"https://pharos.nih.gov/idg/api/v1/targets(5411)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/properties"},"_links":{"count":1439,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/synonyms"},"_publications":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(5411)/publications"},"_namespace":null},{"id":5412,"version":4,"created":1554896347000,"modified":1555036281000,"deprecated":false,"name":"Cyclin-dependent kinase 6","accession":"Q00534","gene":"CDK6","description":"Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. 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Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.133244198476171,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(5426)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(5426)/properties"},"_links":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(5426)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(5426)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(5426)/publications"},"_namespace":null},{"id":5427,"version":2,"created":1554896454000,"modified":1554896456000,"deprecated":false,"name":"Spermatogenesis-associated serine-rich protein 2","accession":"Q86XZ4","gene":"SPATS2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.04483049924935246,"antibodyCount":25,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.590477,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.05453738427799,"pubTatorScore":-0.535112705361082,"self":"https://pharos.nih.gov/idg/api/v1/targets(5427)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(5427)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(5427)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(5427)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(5427)/publications"},"_namespace":null},{"id":5428,"version":3,"created":1554896457000,"modified":1555036290000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF126","accession":"Q9BV68","gene":"RNF126","description":"E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). 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The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.09049906333144,"antibodyCount":94,"monoclonalCount":10,"pubmedCount":null,"jensenScore":123.640367,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":34.33875424534511,"pubTatorScore":1.7182607837684807,"self":"https://pharos.nih.gov/idg/api/v1/targets(5470)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(5470)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(5470)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(5470)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(5470)/publications"},"_namespace":null},{"id":5471,"version":2,"created":1554896678000,"modified":1554896678000,"deprecated":false,"name":"Sperm protein associated with the nucleus on the X chromosome C","accession":"Q9NY87","gene":"SPANXA2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.13469857587152204,"antibodyCount":93,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.261424,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3741369716629218,"self":"https://pharos.nih.gov/idg/api/v1/targets(5471)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(5471)/properties"},"_links":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(5471)/links"},"_synonyms":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(5471)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(5471)/publications"},"_namespace":null},{"id":5472,"version":2,"created":1554896679000,"modified":1554896683000,"deprecated":false,"name":"RNA-binding protein EWS","accession":"Q01844","gene":"EWSR1","description":"Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.043990135170601,"antibodyCount":411,"monoclonalCount":81,"pubmedCount":null,"jensenScore":1141.584372,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.41504454781708,"pubTatorScore":2.6782875971959994,"self":"https://pharos.nih.gov/idg/api/v1/targets(5472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":678,"href":"https://pharos.nih.gov/idg/api/v1/targets(5472)/properties"},"_links":{"count":1443,"href":"https://pharos.nih.gov/idg/api/v1/targets(5472)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(5472)/synonyms"},"_publications":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(5472)/publications"},"_namespace":null},{"id":5473,"version":2,"created":1554896685000,"modified":1554896687000,"deprecated":false,"name":"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4","accession":"Q9NXW9","gene":"ALKBH4","description":"Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5166297904195499,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.066134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.325107740479613,"pubTatorScore":0.7534188844663281,"self":"https://pharos.nih.gov/idg/api/v1/targets(5473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(5473)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(5473)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(5473)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5473)/publications"},"_namespace":null},{"id":5474,"version":3,"created":1554896688000,"modified":1555036319000,"deprecated":false,"name":"Protein cramped-like","accession":"Q96RY5","gene":"CRAMP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.36049462530860577,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.195454,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":0.0,"pubTatorScore":0.6232492903979004,"self":"https://pharos.nih.gov/idg/api/v1/targets(5474)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(5474)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(5474)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(5474)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(5474)/publications"},"_namespace":null},{"id":5475,"version":2,"created":1554896690000,"modified":1554896694000,"deprecated":false,"name":"Intraflagellar transport protein 140 homolog","accession":"Q96RY7","gene":"IFT140","description":"Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance (PubMed:22503633). May play a role in ciliary assembly. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4256780260047988,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":23.311116,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.63469620075736,"pubTatorScore":0.9696488404807252,"self":"https://pharos.nih.gov/idg/api/v1/targets(5475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(5475)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(5475)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(5475)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(5475)/publications"},"_namespace":null},{"id":5476,"version":3,"created":1554896695000,"modified":1555036322000,"deprecated":false,"name":"Negative regulator of reactive oxygen species","accession":"Q86YC3","gene":"NRROS","description":"Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7596678533755202,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.769047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":21.926359713994124,"pubTatorScore":0.6283889300503115,"self":"https://pharos.nih.gov/idg/api/v1/targets(5476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(5476)/properties"},"_links":{"count":809,"href":"https://pharos.nih.gov/idg/api/v1/targets(5476)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(5476)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(5476)/publications"},"_namespace":null},{"id":5477,"version":2,"created":1554896697000,"modified":1554896699000,"deprecated":false,"name":"Ceramide synthase 1","accession":"P27544","gene":"CERS1","description":"May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5889915979693394,"antibodyCount":179,"monoclonalCount":28,"pubmedCount":null,"jensenScore":36.876684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.28049785662785,"pubTatorScore":2.2963605179615616,"self":"https://pharos.nih.gov/idg/api/v1/targets(5477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(5477)/properties"},"_links":{"count":838,"href":"https://pharos.nih.gov/idg/api/v1/targets(5477)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(5477)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(5477)/publications"},"_namespace":null},{"id":5478,"version":3,"created":1554896700000,"modified":1555036323000,"deprecated":false,"name":"Partner and localizer of BRCA2","accession":"Q86YC2","gene":"PALB2","description":"Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.160053343474253,"antibodyCount":154,"monoclonalCount":19,"pubmedCount":null,"jensenScore":165.402725,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.101233691249746,"pubTatorScore":2.2310333208571764,"self":"https://pharos.nih.gov/idg/api/v1/targets(5478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":564,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/properties"},"_links":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/synonyms"},"_publications":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(5478)/publications"},"_namespace":null},{"id":5479,"version":3,"created":1554896705000,"modified":1555036324000,"deprecated":false,"name":"Catenin alpha-2","accession":"P26232","gene":"CTNNA2","description":"May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. 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involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.83274286909019,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(5481)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(5481)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(5481)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(5481)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(5481)/publications"},"_namespace":null},{"id":5482,"version":3,"created":1554896714000,"modified":1555036326000,"deprecated":false,"name":"Protein tyrosine phosphatase domain-containing protein 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Required for the maintenance of the secretory cell lineage in the small intestine. 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Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.1578954841078475,"antibodyCount":134,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.794196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.840033238425566,"pubTatorScore":1.3098484519816325,"self":"https://pharos.nih.gov/idg/api/v1/targets(5564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(5564)/publications"},"_namespace":null},{"id":5565,"version":2,"created":1554897011000,"modified":1554897013000,"deprecated":false,"name":"Pyridoxal phosphate homeostasis protein","accession":"O94903","gene":"PLPBP","description":"Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.230124407524999,"antibodyCount":197,"monoclonalCount":92,"pubmedCount":null,"jensenScore":16.420455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.5642714699198773,"self":"https://pharos.nih.gov/idg/api/v1/targets(5565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(5565)/publications"},"_namespace":null},{"id":5566,"version":3,"created":1554897014000,"modified":1555036379000,"deprecated":false,"name":"Spermatogenesis-associated protein 5-like protein 1","accession":"Q9BVQ7","gene":"SPATA5L1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":82,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.819444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":28.61606601745547,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(5566)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(5566)/publications"},"_namespace":null},{"id":5567,"version":2,"created":1554897017000,"modified":1554897020000,"deprecated":false,"name":"Nuclear pore complex protein Nup85","accession":"Q9BW27","gene":"NUP85","description":"Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). 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Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.9655925965652159,"antibodyCount":111,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.265995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.988390385076784,"pubTatorScore":0.8550417145361918,"self":"https://pharos.nih.gov/idg/api/v1/targets(5724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(5724)/publications"},"_namespace":null},{"id":5725,"version":2,"created":1554897794000,"modified":1554897798000,"deprecated":false,"name":"E3 ubiquitin-protein ligase TRIM37","accession":"O94972","gene":"TRIM37","description":"E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). 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Has anti-HIV activity (PubMed:24317724).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.258919344334969,"antibodyCount":177,"monoclonalCount":12,"pubmedCount":null,"jensenScore":1754.811674,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.773499572813485,"pubTatorScore":1.7144095938423904,"self":"https://pharos.nih.gov/idg/api/v1/targets(5725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(5725)/publications"},"_namespace":null},{"id":5726,"version":3,"created":1554897798000,"modified":1555036457000,"deprecated":false,"name":"AP-2 complex subunit alpha-2","accession":"O94973","gene":"AP2A2","description":"Component of the adaptor protein complex 2 (AP-2). 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AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6599593913271217,"antibodyCount":124,"monoclonalCount":4,"pubmedCount":null,"jensenScore":4.738727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":43.45378749687008,"pubTatorScore":1.1156104783950278,"self":"https://pharos.nih.gov/idg/api/v1/targets(5726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(5726)/properties"},"_links":{"count":1171,"href":"https://pharos.nih.gov/idg/api/v1/targets(5726)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(5726)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(5726)/publications"},"_namespace":null},{"id":5727,"version":2,"created":1554897803000,"modified":1554897805000,"deprecated":false,"name":"Multiple C2 and transmembrane domain-containing protein 2","accession":"Q6DN12","gene":"MCTP2","description":"Might play a role in the development of cardiac outflow tract.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7432880494637362,"antibodyCount":99,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.656246,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.78150699397355,"pubTatorScore":0.6395576041476594,"self":"https://pharos.nih.gov/idg/api/v1/targets(5727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(5727)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(5727)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(5727)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(5727)/publications"},"_namespace":null},{"id":5728,"version":2,"created":1554897806000,"modified":1554897808000,"deprecated":false,"name":"MEF2-activating motif and SAP domain-containing transcriptional regulator","accession":"Q6ZN01","gene":"MAMSTR","description":"Transcriptional coactivator. 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Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). 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Has also an activity of delipidating enzyme for the PE-conjugated 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Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.6707506401633156,"antibodyCount":25,"monoclonalCount":6,"pubmedCount":null,"jensenScore":458.136118,"patentCount":7814,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.11440765202426,"pubTatorScore":2.059062793450173,"self":"https://pharos.nih.gov/idg/api/v1/targets(5938)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(5938)/publications"},"_namespace":null},{"id":5939,"version":3,"created":1554898448000,"modified":1555036585000,"deprecated":false,"name":"Blood vessel epicardial substance","accession":"Q8NE79","gene":"BVES","description":"Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. 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GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). 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In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. 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