{"id":327291,"version":1,"created":1584652229267,"modified":1584652229273,"deprecated":false,"etag":"cf6f64e6002a68da","uri":"https://pharos.nih.gov/idg/api/v1/targets?top=1000&skip=4000","path":"/idg/api/v1/targets","method":"GET","sha1":"97018d676813cb41bf1f03d84edfcc589327cc0f","total":20244,"count":1000,"skip":4000,"top":1000,"status":null,"query":"skip=4000&top=1000","filter":null,"_namespace":null,"content":[{"id":4001,"version":3,"created":1554882307000,"modified":1555035203000,"deprecated":false,"name":"Alpha-globin transcription factor CP2","accession":"Q12800","gene":"TFCP2","description":"Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4486524880975296,"antibodyCount":137,"monoclonalCount":14,"pubmedCount":null,"jensenScore":285.495639,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.3265032220328,"pubTatorScore":1.8120364197259278,"self":"https://pharos.nih.gov/idg/api/v1/targets(4001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/properties"},"_links":{"count":972,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(4001)/publications"},"_namespace":null},{"id":4002,"version":3,"created":1554882311000,"modified":1555035205000,"deprecated":false,"name":"UV-stimulated scaffold protein A","accession":"Q2YD98","gene":"UVSSA","description":"Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8502376814762282,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.928802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.87857380120854,"pubTatorScore":0.9353393095108588,"self":"https://pharos.nih.gov/idg/api/v1/targets(4002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(4002)/publications"},"_namespace":null},{"id":4003,"version":3,"created":1554882314000,"modified":1555035206000,"deprecated":false,"name":"EGF-containing fibulin-like extracellular matrix protein 1","accession":"Q12805","gene":"EFEMP1","description":"Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1730529474432165,"antibodyCount":259,"monoclonalCount":30,"pubmedCount":null,"jensenScore":162.559488,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":29,"knowledgeAvailability":39.10477481206375,"pubTatorScore":2.08554800250724,"self":"https://pharos.nih.gov/idg/api/v1/targets(4003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(4003)/publications"},"_namespace":null},{"id":4004,"version":3,"created":1554882319000,"modified":1555035208000,"deprecated":false,"name":"A-kinase anchor protein 13","accession":"Q12802","gene":"AKAP13","description":"Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4675603119343443,"antibodyCount":156,"monoclonalCount":47,"pubmedCount":null,"jensenScore":291.706901,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":52.72644423905185,"pubTatorScore":1.9853382274376425,"self":"https://pharos.nih.gov/idg/api/v1/targets(4004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(4004)/publications"},"_namespace":null},{"id":4005,"version":3,"created":1554882324000,"modified":1555035210000,"deprecated":false,"name":"Frizzled-1","accession":"Q9UP38","gene":"FZD1","description":"Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-2.070485540008074,"antibodyCount":286,"monoclonalCount":46,"pubmedCount":null,"jensenScore":78.415047,"patentCount":9908,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.961957127636886,"pubTatorScore":1.520565523467197,"self":"https://pharos.nih.gov/idg/api/v1/targets(4005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(4005)/publications"},"_namespace":null},{"id":4006,"version":3,"created":1554882328000,"modified":1554883782000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily H member 2","accession":"Q12809","gene":"KCNH2","description":"Isoform B-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-3.2257531837523574,"antibodyCount":243,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1653.894888,"patentCount":63697,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.5616183168717,"pubTatorScore":3.137747717128631,"self":"https://pharos.nih.gov/idg/api/v1/targets(4006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/properties"},"_links":{"count":5844,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/synonyms"},"_publications":{"count":548,"href":"https://pharos.nih.gov/idg/api/v1/targets(4006)/publications"},"_namespace":null},{"id":4007,"version":2,"created":1554883794000,"modified":1554883794000,"deprecated":false,"name":"Olfactory receptor 11H12","accession":"B2RN74","gene":"OR11H12","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":59,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.02425067207426,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/properties"},"_links":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(4007)/publications"},"_namespace":null},{"id":4008,"version":3,"created":1554883794000,"modified":1555035212000,"deprecated":false,"name":"X-ray repair cross-complementing protein 5","accession":"P13010","gene":"XRCC5","description":"Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.686217116844803,"antibodyCount":874,"monoclonalCount":327,"pubmedCount":null,"jensenScore":470.815482,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":53.955131356933244,"pubTatorScore":2.5674924634882075,"self":"https://pharos.nih.gov/idg/api/v1/targets(4008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/properties"},"_links":{"count":1419,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/synonyms"},"_publications":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(4008)/publications"},"_namespace":null},{"id":4009,"version":3,"created":1554883800000,"modified":1555035215000,"deprecated":false,"name":"Histone-lysine N-methyltransferase SUV39H1","accession":"O43463","gene":"SUV39H1","description":"Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.2755570001574807,"antibodyCount":306,"monoclonalCount":71,"pubmedCount":null,"jensenScore":174.25784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":42.01955828417645,"pubTatorScore":2.091832548707032,"self":"https://pharos.nih.gov/idg/api/v1/targets(4009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(4009)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(4009)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(4009)/synonyms"},"_publications":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(4009)/publications"},"_namespace":null},{"id":4010,"version":3,"created":1554883806000,"modified":1555035216000,"deprecated":false,"name":"Membrane-bound transcription factor site-2 protease","accession":"O43462","gene":"MBTPS2","description":"Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9401545905045592,"antibodyCount":119,"monoclonalCount":20,"pubmedCount":null,"jensenScore":86.137916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.0065763954429,"pubTatorScore":1.8996491848668713,"self":"https://pharos.nih.gov/idg/api/v1/targets(4010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(4010)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(4010)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(4010)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(4010)/publications"},"_namespace":null},{"id":4011,"version":2,"created":1554883810000,"modified":1554883813000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 4A","accession":"P40617","gene":"ARL4A","description":"Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7814445134958115,"antibodyCount":138,"monoclonalCount":8,"pubmedCount":null,"jensenScore":7.845673,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.82896686810421,"pubTatorScore":0.7450376093836986,"self":"https://pharos.nih.gov/idg/api/v1/targets(4011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(4011)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(4011)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(4011)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4011)/publications"},"_namespace":null},{"id":4012,"version":2,"created":1554883813000,"modified":1554883817000,"deprecated":false,"name":"Serine protease HTRA2, mitochondrial","accession":"O43464","gene":"HTRA2","description":"Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.600321087779282,"antibodyCount":519,"monoclonalCount":204,"pubmedCount":null,"jensenScore":392.489065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.280427773920216,"pubTatorScore":2.2468767545400317,"self":"https://pharos.nih.gov/idg/api/v1/targets(4012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(4012)/properties"},"_links":{"count":1190,"href":"https://pharos.nih.gov/idg/api/v1/targets(4012)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(4012)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(4012)/publications"},"_namespace":null},{"id":4013,"version":3,"created":1554883818000,"modified":1555035217000,"deprecated":false,"name":"Tastin","accession":"Q12815","gene":"TROAP","description":"Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9129302512214211,"antibodyCount":66,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.966613,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.963334360744312,"pubTatorScore":0.929440997531788,"self":"https://pharos.nih.gov/idg/api/v1/targets(4013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(4013)/properties"},"_links":{"count":817,"href":"https://pharos.nih.gov/idg/api/v1/targets(4013)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(4013)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(4013)/publications"},"_namespace":null},{"id":4014,"version":2,"created":1554883821000,"modified":1554883823000,"deprecated":false,"name":"Trophinin","accession":"Q12816","gene":"TRO","description":"Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. 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Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. 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Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling 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Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. 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Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6131619890789604,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.721105,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.62246144003869,"pubTatorScore":0.583036818834599,"self":"https://pharos.nih.gov/idg/api/v1/targets(4111)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/properties"},"_links":{"count":1001,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(4111)/publications"},"_namespace":null},{"id":4112,"version":2,"created":1554884157000,"modified":1554884160000,"deprecated":false,"name":"Tumor necrosis factor ligand superfamily member 12","accession":"O43508","gene":"TNFSF12","description":"Binds to FN14 and possibly also to TNRFSF12/APO3. 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Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.180665497530285,"antibodyCount":104,"monoclonalCount":24,"pubmedCount":null,"jensenScore":14.219934,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":40,"knowledgeAvailability":0.0,"pubTatorScore":1.076501687535855,"self":"https://pharos.nih.gov/idg/api/v1/targets(4115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4115)/publications"},"_namespace":null},{"id":4116,"version":3,"created":1554884170000,"modified":1555035285000,"deprecated":false,"name":"LIM/homeobox protein Lhx6","accession":"Q9UPM6","gene":"LHX6","description":"Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. 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Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.1650156516872436,"antibodyCount":702,"monoclonalCount":123,"pubmedCount":null,"jensenScore":140.706283,"patentCount":10886,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":54.756502997767264,"pubTatorScore":2.447185667102484,"self":"https://pharos.nih.gov/idg/api/v1/targets(4231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":625,"href":"https://pharos.nih.gov/idg/api/v1/targets(4231)/properties"},"_links":{"count":1350,"href":"https://pharos.nih.gov/idg/api/v1/targets(4231)/links"},"_synonyms":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(4231)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(4231)/publications"},"_namespace":null},{"id":4232,"version":2,"created":1554884621000,"modified":1554884621000,"deprecated":false,"name":"Endogenous retrovirus group K member 18 Pol protein","accession":"Q9QC07","gene":"ERVK-18","description":"Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. 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Endogenous Pol proteins may have kept, lost or modified their original function during evolution.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.9208187365805955,"self":"https://pharos.nih.gov/idg/api/v1/targets(4232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(4232)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(4232)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(4232)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(4232)/publications"},"_namespace":null},{"id":4233,"version":2,"created":1554884621000,"modified":1554884622000,"deprecated":false,"name":"Chromosome transmission fidelity protein 8 homolog","accession":"P0CG13","gene":"CHTF8","description":"Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":10,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.31390524968544,"pubTatorScore":0.6030928173972966,"self":"https://pharos.nih.gov/idg/api/v1/targets(4233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(4233)/properties"},"_links":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(4233)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(4233)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(4233)/publications"},"_namespace":null},{"id":4234,"version":2,"created":1554884622000,"modified":1554884626000,"deprecated":false,"name":"Myelin protein P0","accession":"P25189","gene":"MPZ","description":"Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. 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Required for signal transduction through retinal depolarizing bipolar cells.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.8770558063502861,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.876899,"patentCount":1282,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.12478368088914,"pubTatorScore":0.7634279935629372,"self":"https://pharos.nih.gov/idg/api/v1/targets(4237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(4237)/properties"},"_links":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(4237)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(4237)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4237)/publications"},"_namespace":null},{"id":4238,"version":2,"created":1554884632000,"modified":1554884633000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-12","accession":"A0A0C4DH73","gene":"IGKV1-12","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.9899331625127389,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(4238)/properties"},"_links":{"count":350,"href":"https://pharos.nih.gov/idg/api/v1/targets(4238)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(4238)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(4238)/publications"},"_namespace":null},{"id":4239,"version":2,"created":1554884633000,"modified":1554884634000,"deprecated":false,"name":"Cementoblastoma-derived protein 1","accession":"Q6PRD7","gene":"CEMP1","description":"May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6283442977284381,"antibodyCount":20,"monoclonalCount":2,"pubmedCount":null,"jensenScore":44.238482,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.400880118236465,"pubTatorScore":0.7061485604848146,"self":"https://pharos.nih.gov/idg/api/v1/targets(4239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(4239)/properties"},"_links":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(4239)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(4239)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(4239)/publications"},"_namespace":null},{"id":4240,"version":2,"created":1554884634000,"modified":1554884635000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-6","accession":"A0A0C4DH72","gene":"IGKV1-6","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.494799757794877,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(4240)/properties"},"_links":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(4240)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(4240)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4240)/publications"},"_namespace":null},{"id":4241,"version":2,"created":1554884635000,"modified":1554884640000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(q) subunit alpha","accession":"P50148","gene":"GNAQ","description":"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 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The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.845156239374276,"antibodyCount":69,"monoclonalCount":6,"pubmedCount":null,"jensenScore":693.886385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.23960612847433,"pubTatorScore":1.7380404546864299,"self":"https://pharos.nih.gov/idg/api/v1/targets(4248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(4248)/properties"},"_links":{"count":1060,"href":"https://pharos.nih.gov/idg/api/v1/targets(4248)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(4248)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(4248)/publications"},"_namespace":null},{"id":4249,"version":3,"created":1554884671000,"modified":1555035356000,"deprecated":false,"name":"Hydroxycarboxylic acid receptor 1","accession":"Q9BXC0","gene":"HCAR1","description":"Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.4258787557768737,"antibodyCount":294,"monoclonalCount":1,"pubmedCount":null,"jensenScore":32.506678,"patentCount":3242,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":23.146758266955587,"pubTatorScore":1.316907807640621,"self":"https://pharos.nih.gov/idg/api/v1/targets(4249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(4249)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(4249)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(4249)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(4249)/publications"},"_namespace":null},{"id":4250,"version":2,"created":1554884676000,"modified":1554884681000,"deprecated":false,"name":"Probable G-protein coupled receptor 174","accession":"Q9BXC1","gene":"GPR174","description":"Putative receptor for purines coupled to G-proteins.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-0.9328709442066855,"antibodyCount":185,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.948214,"patentCount":1421,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.962145949764775,"pubTatorScore":0.9029607108579081,"self":"https://pharos.nih.gov/idg/api/v1/targets(4250)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(4250)/properties"},"_links":{"count":656,"href":"https://pharos.nih.gov/idg/api/v1/targets(4250)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(4250)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(4250)/publications"},"_namespace":null},{"id":4251,"version":3,"created":1554884682000,"modified":1555035358000,"deprecated":false,"name":"Nuclear receptor subfamily 2 group C member 2","accession":"P49116","gene":"NR2C2","description":"Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.","idgFamily":"Nuclear Receptor","idgTDL":"Tchem","novelty":-1.6896421477381822,"antibodyCount":428,"monoclonalCount":91,"pubmedCount":null,"jensenScore":45.767241,"patentCount":24606,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.45928184590826,"pubTatorScore":1.7884832760553027,"self":"https://pharos.nih.gov/idg/api/v1/targets(4251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":495,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/properties"},"_links":{"count":1062,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(4251)/publications"},"_namespace":null},{"id":4252,"version":3,"created":1554884687000,"modified":1555035361000,"deprecated":false,"name":"Serine/threonine-protein phosphatase PP1-alpha catalytic subunit","accession":"P62136","gene":"PPP1CA","description":"Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.170098277709012,"antibodyCount":378,"monoclonalCount":152,"pubmedCount":null,"jensenScore":138.965123,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":53.750061734148915,"pubTatorScore":1.9839547745123438,"self":"https://pharos.nih.gov/idg/api/v1/targets(4252)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":593,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/links"},"_synonyms":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/synonyms"},"_publications":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(4252)/publications"},"_namespace":null},{"id":4253,"version":2,"created":1554884692000,"modified":1554884693000,"deprecated":false,"name":"Clarin-2","accession":"A0PK11","gene":"CLRN2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.873234345753584,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4253)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/properties"},"_links":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(4253)/publications"},"_namespace":null},{"id":4254,"version":2,"created":1554884693000,"modified":1554884695000,"deprecated":false,"name":"Spermatogenesis-associated protein 16","accession":"Q9BXB7","gene":"SPATA16","description":"Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8549563543774241,"antibodyCount":48,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.023229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.45727427645801,"pubTatorScore":1.1077751007128323,"self":"https://pharos.nih.gov/idg/api/v1/targets(4254)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/properties"},"_links":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/links"},"_synonyms":{"count":1537,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4254)/publications"},"_namespace":null},{"id":4255,"version":2,"created":1554884695000,"modified":1554884697000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 10","accession":"Q9BXB5","gene":"OSBPL10","description":"Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6989653574099235,"antibodyCount":127,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.126989,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.08402719573601,"pubTatorScore":0.7767703896181177,"self":"https://pharos.nih.gov/idg/api/v1/targets(4255)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":277,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(4255)/publications"},"_namespace":null},{"id":4256,"version":2,"created":1554884698000,"modified":1554884701000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 11","accession":"Q9BXB4","gene":"OSBPL11","description":"Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3925992616264472,"antibodyCount":185,"monoclonalCount":62,"pubmedCount":null,"jensenScore":3.031907,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.653917843842414,"pubTatorScore":0.5467112899860862,"self":"https://pharos.nih.gov/idg/api/v1/targets(4256)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(4256)/publications"},"_namespace":null},{"id":4257,"version":3,"created":1554884701000,"modified":1555035363000,"deprecated":false,"name":"Serine/threonine-protein phosphatase PP1-beta catalytic subunit","accession":"P62140","gene":"PPP1CB","description":"Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5519180599654543,"antibodyCount":377,"monoclonalCount":58,"pubmedCount":null,"jensenScore":33.307632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":52.17153948574055,"pubTatorScore":1.4370989653804467,"self":"https://pharos.nih.gov/idg/api/v1/targets(4257)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":507,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/properties"},"_links":{"count":1158,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(4257)/publications"},"_namespace":null},{"id":4258,"version":3,"created":1554884706000,"modified":1555035365000,"deprecated":false,"name":"Leucine-rich repeat-containing G-protein coupled receptor 4","accession":"Q9BXB1","gene":"LGR4","description":"Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.7560432121556984,"antibodyCount":230,"monoclonalCount":83,"pubmedCount":null,"jensenScore":72.221856,"patentCount":6748,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":37.86368511709624,"pubTatorScore":1.517872619023379,"self":"https://pharos.nih.gov/idg/api/v1/targets(4258)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(4258)/publications"},"_namespace":null},{"id":4259,"version":2,"created":1554884709000,"modified":1554884710000,"deprecated":false,"name":"Transmembrane protein 72","accession":"A0PK05","gene":"TMEM72","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3631779028471202,"antibodyCount":13,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.433333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.75742378143848,"pubTatorScore":0.08754469119603969,"self":"https://pharos.nih.gov/idg/api/v1/targets(4259)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/properties"},"_links":{"count":617,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(4259)/publications"},"_namespace":null},{"id":4260,"version":2,"created":1554884711000,"modified":1554884713000,"deprecated":false,"name":"Transmembrane protein 120B","accession":"A0PK00","gene":"TMEM120B","description":"Necessary for efficient adipogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.40576534695952005,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.299145,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.11694622413195,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(4260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4260)/publications"},"_namespace":null},{"id":4261,"version":2,"created":1554884713000,"modified":1554884717000,"deprecated":false,"name":"Polyubiquitin-B","accession":"P0CG47","gene":"UBB","description":"Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in 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Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.118573684915794,"antibodyCount":133,"monoclonalCount":36,"pubmedCount":null,"jensenScore":120.313047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":34.14080191664441,"pubTatorScore":1.0649344408530759,"self":"https://pharos.nih.gov/idg/api/v1/targets(4429)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/properties"},"_links":{"count":1053,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(4429)/publications"},"_namespace":null},{"id":4430,"version":2,"created":1554888644000,"modified":1554888647000,"deprecated":false,"name":"Synaptotagmin-7","accession":"O43581","gene":"SYT7","description":"Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.759305262478777,"antibodyCount":170,"monoclonalCount":68,"pubmedCount":null,"jensenScore":60.314332,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.11661032637718,"pubTatorScore":1.391173197623178,"self":"https://pharos.nih.gov/idg/api/v1/targets(4430)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(4430)/publications"},"_namespace":null},{"id":4431,"version":4,"created":1554888648000,"modified":1555035564000,"deprecated":false,"name":"ATP-binding cassette sub-family G member 2","accession":"Q9UNQ0","gene":"ABCG2","description":"High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-3.418767365581369,"antibodyCount":246,"monoclonalCount":137,"pubmedCount":null,"jensenScore":2731.120017,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":49.4031690434656,"pubTatorScore":3.253236050485231,"self":"https://pharos.nih.gov/idg/api/v1/targets(4431)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/properties"},"_links":{"count":1768,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/links"},"_synonyms":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/synonyms"},"_publications":{"count":699,"href":"https://pharos.nih.gov/idg/api/v1/targets(4431)/publications"},"_namespace":null},{"id":4432,"version":2,"created":1554888714000,"modified":1554888717000,"deprecated":false,"name":"Proline-serine-threonine phosphatase-interacting protein 1","accession":"O43586","gene":"PSTPIP1","description":"Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.898831568972295,"antibodyCount":119,"monoclonalCount":9,"pubmedCount":null,"jensenScore":82.271085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.104776146173535,"pubTatorScore":1.6479108940136782,"self":"https://pharos.nih.gov/idg/api/v1/targets(4432)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/properties"},"_links":{"count":859,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(4432)/publications"},"_namespace":null},{"id":4433,"version":3,"created":1554888717000,"modified":1555035570000,"deprecated":false,"name":"Flap endonuclease 1","accession":"P39748","gene":"FEN1","description":"Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.791706479342493,"antibodyCount":406,"monoclonalCount":126,"pubmedCount":null,"jensenScore":616.995314,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":52.45461586048814,"pubTatorScore":2.524267532427015,"self":"https://pharos.nih.gov/idg/api/v1/targets(4433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":595,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/properties"},"_links":{"count":1263,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/synonyms"},"_publications":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(4433)/publications"},"_namespace":null},{"id":4434,"version":2,"created":1554888735000,"modified":1554888740000,"deprecated":false,"name":"DNA mismatch repair protein Msh6","accession":"P52701","gene":"MSH6","description":"Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.725936874223874,"antibodyCount":479,"monoclonalCount":208,"pubmedCount":null,"jensenScore":572.307433,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":59.800627479482436,"pubTatorScore":2.7370282812563556,"self":"https://pharos.nih.gov/idg/api/v1/targets(4434)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":752,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/properties"},"_links":{"count":1354,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/synonyms"},"_publications":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(4434)/publications"},"_namespace":null},{"id":4435,"version":2,"created":1554888742000,"modified":1554888745000,"deprecated":false,"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2","accession":"Q00722","gene":"PLCB2","description":"The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1404756345874145,"antibodyCount":104,"monoclonalCount":10,"pubmedCount":null,"jensenScore":137.848655,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.801357983482774,"pubTatorScore":1.9534221587167033,"self":"https://pharos.nih.gov/idg/api/v1/targets(4435)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":550,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(4435)/publications"},"_namespace":null},{"id":4436,"version":2,"created":1554888746000,"modified":1554888746000,"deprecated":false,"name":"Putative uncharacterized protein ATP1A1-AS1","accession":"Q5TC04","gene":"ATP1A1-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.858388134022382,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/properties"},"_links":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(4436)/publications"},"_namespace":null},{"id":4437,"version":3,"created":1554888746000,"modified":1555035573000,"deprecated":false,"name":"Protein S100-A4","accession":"P26447","gene":"S100A4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.775671572741567,"antibodyCount":478,"monoclonalCount":130,"pubmedCount":null,"jensenScore":622.249541,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":55,"knowledgeAvailability":35.58355972102706,"pubTatorScore":2.6227659909855965,"self":"https://pharos.nih.gov/idg/api/v1/targets(4437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":601,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/links"},"_synonyms":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/synonyms"},"_publications":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(4437)/publications"},"_namespace":null},{"id":4438,"version":3,"created":1554888752000,"modified":1554888851000,"deprecated":false,"name":"Proteinase-activated receptor 1","accession":"P25116","gene":"F2R","description":"High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.7839317919586373,"antibodyCount":453,"monoclonalCount":104,"pubmedCount":null,"jensenScore":550.961553,"patentCount":77288,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.896123683167865,"pubTatorScore":2.8458893700191283,"self":"https://pharos.nih.gov/idg/api/v1/targets(4438)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":748,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/properties"},"_links":{"count":1560,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/synonyms"},"_publications":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(4438)/publications"},"_namespace":null},{"id":4439,"version":2,"created":1554888853000,"modified":1554888856000,"deprecated":false,"name":"Anoctamin-4","accession":"Q32M45","gene":"ANO4","description":"Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6303001183881455,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.246989,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.024713833020144,"pubTatorScore":0.6406112090199498,"self":"https://pharos.nih.gov/idg/api/v1/targets(4439)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/properties"},"_links":{"count":753,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4439)/publications"},"_namespace":null},{"id":4440,"version":2,"created":1554888856000,"modified":1554888858000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 3","accession":"Q9BY71","gene":"LRRC3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4756827202120514,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.749972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.79427346538844,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(4440)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/properties"},"_links":{"count":764,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(4440)/publications"},"_namespace":null},{"id":4441,"version":2,"created":1554888858000,"modified":1554888862000,"deprecated":false,"name":"BUB3-interacting and GLEBS motif-containing protein ZNF207","accession":"O43670","gene":"ZNF207","description":"Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.821458946403718,"antibodyCount":264,"monoclonalCount":158,"pubmedCount":null,"jensenScore":6.926379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.40616599763821,"pubTatorScore":0.8900016131846367,"self":"https://pharos.nih.gov/idg/api/v1/targets(4441)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(4441)/publications"},"_namespace":null},{"id":4442,"version":3,"created":1554888863000,"modified":1555035576000,"deprecated":false,"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3","accession":"O43676","gene":"NDUFB3","description":"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-0.5371191853600467,"antibodyCount":70,"monoclonalCount":33,"pubmedCount":null,"jensenScore":3.235354,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":37.7718018245564,"pubTatorScore":3.680728376074048,"self":"https://pharos.nih.gov/idg/api/v1/targets(4442)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(4442)/publications"},"_namespace":null},{"id":4443,"version":3,"created":1554888867000,"modified":1555035577000,"deprecated":false,"name":"Polymerase delta-interacting protein 3","accession":"Q9BY77","gene":"POLDIP3","description":"Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. 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Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.177681121051649,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.25366,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.050617990974786,"pubTatorScore":1.3328077359813306,"self":"https://pharos.nih.gov/idg/api/v1/targets(4490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/properties"},"_links":{"count":1031,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(4490)/publications"},"_namespace":null},{"id":4491,"version":2,"created":1554889010000,"modified":1554889012000,"deprecated":false,"name":"Protein RTF2 homolog","accession":"Q9BY42","gene":"RTF2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":78,"monoclonalCount":28,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4491)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(4491)/publications"},"_namespace":null},{"id":4492,"version":3,"created":1554889012000,"modified":1555035617000,"deprecated":false,"name":"Protein regulator of cytokinesis 1","accession":"O43663","gene":"PRC1","description":"Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. 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Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.26145805201421,"antibodyCount":239,"monoclonalCount":31,"pubmedCount":null,"jensenScore":184.76919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":50.771928751319955,"pubTatorScore":2.042470694257048,"self":"https://pharos.nih.gov/idg/api/v1/targets(4511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/properties"},"_links":{"count":1245,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(4511)/publications"},"_namespace":null},{"id":4512,"version":2,"created":1554889205000,"modified":1554889208000,"deprecated":false,"name":"CD82 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Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.041392684723930574,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.953968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(4517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4517)/publications"},"_namespace":null},{"id":4518,"version":3,"created":1554889226000,"modified":1555035637000,"deprecated":false,"name":"R-spondin-3","accession":"Q9BXY4","gene":"RSPO3","description":"Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3328606929366345,"antibodyCount":138,"monoclonalCount":20,"pubmedCount":null,"jensenScore":23.209912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.588997697298932,"pubTatorScore":1.207931459950917,"self":"https://pharos.nih.gov/idg/api/v1/targets(4518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(4518)/publications"},"_namespace":null},{"id":4519,"version":3,"created":1554889230000,"modified":1555035639000,"deprecated":false,"name":"Nuclear cap-binding protein subunit 1","accession":"Q09161","gene":"NCBP1","description":"Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3413362201199885,"antibodyCount":172,"monoclonalCount":11,"pubmedCount":null,"jensenScore":207.70389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.627015668190666,"pubTatorScore":1.6503846011332794,"self":"https://pharos.nih.gov/idg/api/v1/targets(4519)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(4519)/publications"},"_namespace":null},{"id":4520,"version":2,"created":1554889234000,"modified":1554889236000,"deprecated":false,"name":"Protein BEX2","accession":"Q9BXY8","gene":"BEX2","description":"Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase 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Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. 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Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.815737398258812,"antibodyCount":546,"monoclonalCount":174,"pubmedCount":null,"jensenScore":706.516351,"patentCount":6852,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":44.39786351230458,"pubTatorScore":2.7606369787054743,"self":"https://pharos.nih.gov/idg/api/v1/targets(4561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":658,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/properties"},"_links":{"count":1279,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/synonyms"},"_publications":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(4561)/publications"},"_namespace":null},{"id":4562,"version":2,"created":1554889819000,"modified":1554889819000,"deprecated":false,"name":"T-complex protein 11 X-linked protein 1","accession":"B4DZS4","gene":"TCP11X1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.312496128557586,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4562)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/properties"},"_links":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(4562)/publications"},"_namespace":null},{"id":4563,"version":2,"created":1554889819000,"modified":1554889822000,"deprecated":false,"name":"Periaxin","accession":"Q9BXM0","gene":"PRX","description":"Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6552429542744065,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":45.490245,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.12023973475436,"pubTatorScore":2.2229681199881655,"self":"https://pharos.nih.gov/idg/api/v1/targets(4563)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(4563)/publications"},"_namespace":null},{"id":4564,"version":3,"created":1554889823000,"modified":1555035666000,"deprecated":false,"name":"Twinfilin-1","accession":"Q12792","gene":"TWF1","description":"Actin-binding protein involved in motile and morphological processes. 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It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-3.096486782179718,"antibodyCount":222,"monoclonalCount":50,"pubmedCount":null,"jensenScore":1238.469333,"patentCount":36302,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.002412338710606,"pubTatorScore":2.485832377386495,"self":"https://pharos.nih.gov/idg/api/v1/targets(4565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":573,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/properties"},"_links":{"count":1266,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(4565)/publications"},"_namespace":null},{"id":4566,"version":2,"created":1554889848000,"modified":1554889850000,"deprecated":false,"name":"Proline-rich nuclear receptor coactivator 1","accession":"Q12796","gene":"PNRC1","description":"Nuclear receptor coactivator. 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Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.917828625755139,"pubTatorScore":0.07493048280725821,"self":"https://pharos.nih.gov/idg/api/v1/targets(4570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/properties"},"_links":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(4570)/publications"},"_namespace":null},{"id":4571,"version":2,"created":1554889863000,"modified":1554889864000,"deprecated":false,"name":"T-complex protein 10A homolog","accession":"Q12799","gene":"TCP10","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1159273436326,"antibodyCount":66,"monoclonalCount":6,"pubmedCount":null,"jensenScore":12.592567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.357801673318038,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(4571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/properties"},"_links":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(4571)/publications"},"_namespace":null},{"id":4572,"version":2,"created":1554889864000,"modified":1554889864000,"deprecated":false,"name":"Immunoglobulin lambda constant 6","accession":"P0CF74","gene":"IGLC6","description":"Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. 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This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. 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In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6856081273965535,"antibodyCount":133,"monoclonalCount":31,"pubmedCount":null,"jensenScore":4.940335,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":17.03243658933499,"pubTatorScore":0.9615821565981814,"self":"https://pharos.nih.gov/idg/api/v1/targets(4673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/properties"},"_links":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(4673)/publications"},"_namespace":null},{"id":4674,"version":3,"created":1554891473000,"modified":1555035743000,"deprecated":false,"name":"Interleukin-36 gamma","accession":"Q9NZH8","gene":"IL36G","description":"Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. 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May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. 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Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9053460729058048,"antibodyCount":107,"monoclonalCount":4,"pubmedCount":null,"jensenScore":8.774809,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.42792718170876,"pubTatorScore":0.637775529308494,"self":"https://pharos.nih.gov/idg/api/v1/targets(4676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(4676)/publications"},"_namespace":null},{"id":4677,"version":3,"created":1554891480000,"modified":1555035746000,"deprecated":false,"name":"Voltage-dependent L-type calcium channel subunit alpha-1C","accession":"Q13936","gene":"CACNA1C","description":"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. 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Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. 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May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6002466420957517,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.820262,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":25.26898597234288,"pubTatorScore":0.6872315415723759,"self":"https://pharos.nih.gov/idg/api/v1/targets(4688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/properties"},"_links":{"count":961,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(4688)/publications"},"_namespace":null},{"id":4689,"version":2,"created":1554891559000,"modified":1554891562000,"deprecated":false,"name":"Kv channel-interacting protein 1","accession":"Q9NZI2","gene":"KCNIP1","description":"Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. 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Increases the presence of KCND2 at the cell surface.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.5248735463793874,"antibodyCount":222,"monoclonalCount":111,"pubmedCount":null,"jensenScore":33.116193,"patentCount":2535,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.873291990886166,"pubTatorScore":1.4944417180699543,"self":"https://pharos.nih.gov/idg/api/v1/targets(4689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(4689)/publications"},"_namespace":null},{"id":4690,"version":3,"created":1554891562000,"modified":1555035760000,"deprecated":false,"name":"Pre-B-cell leukemia transcription factor 1","accession":"P40424","gene":"PBX1","description":"Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3064040624906137,"antibodyCount":232,"monoclonalCount":96,"pubmedCount":null,"jensenScore":200.04704,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.41577346917104,"pubTatorScore":2.0909764821049577,"self":"https://pharos.nih.gov/idg/api/v1/targets(4690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":523,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/synonyms"},"_publications":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(4690)/publications"},"_namespace":null},{"id":4691,"version":3,"created":1554891567000,"modified":1555035762000,"deprecated":false,"name":"MAP/microtubule affinity-regulating kinase 3","accession":"P27448","gene":"MARK3","description":"Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.481653229865026,"antibodyCount":314,"monoclonalCount":89,"pubmedCount":null,"jensenScore":289.639078,"patentCount":4384,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":45.114132310393195,"pubTatorScore":2.3617901565805552,"self":"https://pharos.nih.gov/idg/api/v1/targets(4691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(4691)/publications"},"_namespace":null},{"id":4692,"version":2,"created":1554891573000,"modified":1554891576000,"deprecated":false,"name":"Grainyhead-like protein 1 homolog","accession":"Q9NZI5","gene":"GRHL1","description":"Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed:12175488).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5810353417543268,"antibodyCount":95,"monoclonalCount":2,"pubmedCount":null,"jensenScore":30.633459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.837419742241416,"pubTatorScore":1.258667663122169,"self":"https://pharos.nih.gov/idg/api/v1/targets(4692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(4692)/publications"},"_namespace":null},{"id":4693,"version":2,"created":1554891577000,"modified":1554891579000,"deprecated":false,"name":"Transcription factor CP2-like protein 1","accession":"Q9NZI6","gene":"TFCP2L1","description":"Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1070058922487274,"antibodyCount":231,"monoclonalCount":2,"pubmedCount":null,"jensenScore":12.384972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.97980990720374,"pubTatorScore":0.9526310414275215,"self":"https://pharos.nih.gov/idg/api/v1/targets(4693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(4693)/publications"},"_namespace":null},{"id":4694,"version":2,"created":1554891580000,"modified":1554891581000,"deprecated":false,"name":"Sodium/myo-inositol cotransporter","accession":"P53794","gene":"SLC5A3","description":"Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.6204287282065688,"antibodyCount":145,"monoclonalCount":20,"pubmedCount":null,"jensenScore":40.414464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.778988761014546,"pubTatorScore":1.9117874809058775,"self":"https://pharos.nih.gov/idg/api/v1/targets(4694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/properties"},"_links":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(4694)/publications"},"_namespace":null},{"id":4695,"version":2,"created":1554891581000,"modified":1554891583000,"deprecated":false,"name":"Upstream-binding protein 1","accession":"Q9NZI7","gene":"UBP1","description":"Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6964085041579047,"antibodyCount":194,"monoclonalCount":49,"pubmedCount":null,"jensenScore":47.421917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.124395602663576,"pubTatorScore":1.1372485320589412,"self":"https://pharos.nih.gov/idg/api/v1/targets(4695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(4695)/publications"},"_namespace":null},{"id":4696,"version":2,"created":1554891585000,"modified":1554891587000,"deprecated":false,"name":"Insulin-like growth factor 2 mRNA-binding protein 1","accession":"Q9NZI8","gene":"IGF2BP1","description":"RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8599667349577487,"antibodyCount":207,"monoclonalCount":3,"pubmedCount":null,"jensenScore":76.008891,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.103011634081845,"pubTatorScore":2.230665215136594,"self":"https://pharos.nih.gov/idg/api/v1/targets(4696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/synonyms"},"_publications":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(4696)/publications"},"_namespace":null},{"id":4697,"version":2,"created":1554891588000,"modified":1554891590000,"deprecated":false,"name":"Protein CASP","accession":"Q13948","gene":"CUX1","description":"May be involved in intra-Golgi retrograde transport.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.4350452909445885,"antibodyCount":295,"monoclonalCount":40,"pubmedCount":null,"jensenScore":487.871765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.903472001330128,"self":"https://pharos.nih.gov/idg/api/v1/targets(4697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/properties"},"_links":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(4697)/publications"},"_namespace":null},{"id":4698,"version":3,"created":1554891591000,"modified":1554891752000,"deprecated":false,"name":"High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A","accession":"Q13946","gene":"PDE7A","description":"Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-1.9157419638136257,"antibodyCount":162,"monoclonalCount":5,"pubmedCount":null,"jensenScore":84.851784,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.29194806764512,"pubTatorScore":1.815184115125523,"self":"https://pharos.nih.gov/idg/api/v1/targets(4698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/properties"},"_links":{"count":1355,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(4698)/publications"},"_namespace":null},{"id":4699,"version":2,"created":1554891754000,"modified":1554891754000,"deprecated":false,"name":"Immunoglobulin heavy variable 1-69-2","accession":"A0A0G2JMI3","gene":"IGHV1-69-2","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(4699)/publications"},"_namespace":null},{"id":4700,"version":3,"created":1554891754000,"modified":1555035764000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 8","accession":"Q5TAQ9","gene":"DCAF8","description":"May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7089871237906594,"antibodyCount":50,"monoclonalCount":11,"pubmedCount":null,"jensenScore":4.897912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":35.32180426407417,"pubTatorScore":0.9727977105422994,"self":"https://pharos.nih.gov/idg/api/v1/targets(4700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/properties"},"_links":{"count":1107,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(4700)/publications"},"_namespace":null},{"id":4701,"version":3,"created":1554891759000,"modified":1555035766000,"deprecated":false,"name":"L-selectin","accession":"P14151","gene":"SELL","description":"Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.4650478790419235,"antibodyCount":1166,"monoclonalCount":878,"pubmedCount":null,"jensenScore":2829.944761,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":38.08095858817714,"pubTatorScore":3.1713356175269496,"self":"https://pharos.nih.gov/idg/api/v1/targets(4701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/properties"},"_links":{"count":1117,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/synonyms"},"_publications":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(4701)/publications"},"_namespace":null},{"id":4702,"version":2,"created":1554891765000,"modified":1554891765000,"deprecated":false,"name":"Endogenous retrovirus group K member 21 Pro protein","accession":"P63119","gene":"ERVK-21","description":"Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(4702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(4702)/publications"},"_namespace":null},{"id":4703,"version":2,"created":1554891765000,"modified":1554891767000,"deprecated":false,"name":"Prospero homeobox protein 2","accession":"Q3B8N5","gene":"PROX2","description":"Transcription regulator. 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Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. 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Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). 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Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). 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Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. 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Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). 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Required to mediate CEP290 association with microtubules.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9582452641980094,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.533334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.426197371221168,"pubTatorScore":0.9294189257142927,"self":"https://pharos.nih.gov/idg/api/v1/targets(4722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(4722)/publications"},"_namespace":null},{"id":4723,"version":2,"created":1554891862000,"modified":1554891864000,"deprecated":false,"name":"Protocadherin beta-10","accession":"Q9UN67","gene":"PCDHB10","description":"Potential calcium-dependent cell-adhesion protein. 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May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.3725644979900773,"antibodyCount":83,"monoclonalCount":4,"pubmedCount":null,"jensenScore":237.978421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.29690382340693,"pubTatorScore":1.5890630153518006,"self":"https://pharos.nih.gov/idg/api/v1/targets(4727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(4727)/publications"},"_namespace":null},{"id":4728,"version":3,"created":1554891879000,"modified":1555035788000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DDX6","accession":"P26196","gene":"DDX6","description":"In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8148078580922502,"antibodyCount":302,"monoclonalCount":30,"pubmedCount":null,"jensenScore":65.559468,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":45.35609504916781,"pubTatorScore":1.637498085097855,"self":"https://pharos.nih.gov/idg/api/v1/targets(4728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/properties"},"_links":{"count":1148,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(4728)/publications"},"_namespace":null},{"id":4729,"version":3,"created":1554891883000,"modified":1555035790000,"deprecated":false,"name":"WW domain-containing oxidoreductase","accession":"Q9NZC7","gene":"WWOX","description":"Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.6168311729425713,"antibodyCount":251,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3311.442972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":54.8997184890683,"pubTatorScore":2.405100857204714,"self":"https://pharos.nih.gov/idg/api/v1/targets(4729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":645,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/synonyms"},"_publications":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(4729)/publications"},"_namespace":null},{"id":4730,"version":2,"created":1554891890000,"modified":1554891893000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1","accession":"Q9NZC9","gene":"SMARCAL1","description":"ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7485233622883587,"antibodyCount":133,"monoclonalCount":8,"pubmedCount":null,"jensenScore":65.061731,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.106084812385106,"pubTatorScore":1.8633511835260066,"self":"https://pharos.nih.gov/idg/api/v1/targets(4730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(4730)/publications"},"_namespace":null},{"id":4731,"version":3,"created":1554891894000,"modified":1555035792000,"deprecated":false,"name":"RNA-binding motif protein, X chromosome","accession":"P38159","gene":"RBMX","description":"RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5240151871246796,"antibodyCount":98,"monoclonalCount":3,"pubmedCount":null,"jensenScore":35.809034,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":46.30885998611814,"pubTatorScore":1.3473764677029987,"self":"https://pharos.nih.gov/idg/api/v1/targets(4731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(4731)/publications"},"_namespace":null},{"id":4732,"version":3,"created":1554891898000,"modified":1555035795000,"deprecated":false,"name":"RNA-binding protein 4","accession":"Q9BWF3","gene":"RBM4","description":"RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. 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When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3354398148722746,"antibodyCount":168,"monoclonalCount":19,"pubmedCount":null,"jensenScore":208.550448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":43.45225453469404,"pubTatorScore":1.8740315532355036,"self":"https://pharos.nih.gov/idg/api/v1/targets(4777)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":514,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/links"},"_synonyms":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(4777)/publications"},"_namespace":null},{"id":4778,"version":2,"created":1554892030000,"modified":1554892034000,"deprecated":false,"name":"Ubiquilin-1","accession":"Q9UMX0","gene":"UBQLN1","description":"Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. 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Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. 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The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. 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Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2594839132036413,"antibodyCount":74,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.186383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":25.88509398841457,"pubTatorScore":0.7524599486017405,"self":"https://pharos.nih.gov/idg/api/v1/targets(4864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/properties"},"_links":{"count":787,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(4864)/publications"},"_namespace":null},{"id":4865,"version":3,"created":1554892311000,"modified":1555035901000,"deprecated":false,"name":"Pre-mRNA-processing factor 19","accession":"Q9UMS4","gene":"PRPF19","description":"Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. 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'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7152370733539037,"antibodyCount":234,"monoclonalCount":29,"pubmedCount":null,"jensenScore":54.247762,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":38.697156179055064,"pubTatorScore":1.7746241174094766,"self":"https://pharos.nih.gov/idg/api/v1/targets(4865)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/properties"},"_links":{"count":1193,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(4865)/publications"},"_namespace":null},{"id":4866,"version":3,"created":1554892315000,"modified":1555035903000,"deprecated":false,"name":"Intraflagellar transport protein 27 homolog","accession":"Q9BW83","gene":"IFT27","description":"Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). 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Forms a subcomplex within the IFT complex B with IFT25 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2449573484226266,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.545002,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":37.130694336665954,"pubTatorScore":0.9927007465366534,"self":"https://pharos.nih.gov/idg/api/v1/targets(4866)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(4866)/publications"},"_namespace":null},{"id":4867,"version":3,"created":1554892319000,"modified":1555035905000,"deprecated":false,"name":"Chloride intracellular channel protein 5","accession":"Q9NZA1","gene":"CLIC5","description":"Required for normal hearing (PubMed:24781754). 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Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). 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Involved in HIV-1 p6- and p9-dependent virus release.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3580443672937186,"antibodyCount":157,"monoclonalCount":11,"pubmedCount":null,"jensenScore":24.250462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":36.87907089231076,"pubTatorScore":1.193222860283651,"self":"https://pharos.nih.gov/idg/api/v1/targets(4999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/properties"},"_links":{"count":1074,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(4999)/publications"},"_namespace":null},{"id":5000,"version":2,"created":1554893488000,"modified":1554893491000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 9","accession":"O43307","gene":"ARHGEF9","description":"Acts as guanine nucleotide exchange factor (GEF) for CDC42. 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