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Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5745495816419546,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":34.383268,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.7928067580436,"pubTatorScore":2.1564097095169408,"self":"https://pharos.nih.gov/idg/api/v1/targets(17010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(17010)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(17010)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(17010)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17010)/publications"},"_namespace":null},{"id":17011,"version":3,"created":1554996405000,"modified":1555043693000,"deprecated":false,"name":"Nuclear protein 1","accession":"O60356","gene":"NUPR1","description":"Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7886992078533788,"antibodyCount":109,"monoclonalCount":6,"pubmedCount":null,"jensenScore":54.713793,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.366473259114414,"pubTatorScore":1.7972258825805965,"self":"https://pharos.nih.gov/idg/api/v1/targets(17011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(17011)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(17011)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(17011)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(17011)/publications"},"_namespace":null},{"id":17012,"version":2,"created":1554996410000,"modified":1554996413000,"deprecated":false,"name":"Putative D-tyrosyl-tRNA(Tyr) deacylase 2","accession":"Q96FN9","gene":"DTD2","description":"May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). 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Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.63746569197817,"antibodyCount":260,"monoclonalCount":25,"pubmedCount":null,"jensenScore":44.458994,"patentCount":7982,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.715218022913874,"pubTatorScore":1.397588261452994,"self":"https://pharos.nih.gov/idg/api/v1/targets(17013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(17013)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(17013)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(17013)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(17013)/publications"},"_namespace":null},{"id":17014,"version":2,"created":1554996421000,"modified":1554996426000,"deprecated":false,"name":"Homeobox protein SIX5","accession":"Q8N196","gene":"SIX5","description":"Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.502449782061757,"antibodyCount":115,"monoclonalCount":2,"pubmedCount":null,"jensenScore":299.223844,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.423245115822354,"pubTatorScore":1.9283110694939036,"self":"https://pharos.nih.gov/idg/api/v1/targets(17014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(17014)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(17014)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(17014)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(17014)/publications"},"_namespace":null},{"id":17015,"version":2,"created":1554996427000,"modified":1554996430000,"deprecated":false,"name":"Multiple epidermal growth factor-like domains protein 11","accession":"A6BM72","gene":"MEGF11","description":"May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. 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May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.797941831080026,"antibodyCount":141,"monoclonalCount":13,"pubmedCount":null,"jensenScore":67.224986,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.05479141674583,"pubTatorScore":1.4543275587499311,"self":"https://pharos.nih.gov/idg/api/v1/targets(17264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/properties"},"_links":{"count":1129,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(17264)/publications"},"_namespace":null},{"id":17265,"version":4,"created":1554999244000,"modified":1555043883000,"deprecated":false,"name":"RAC-beta serine/threonine-protein kinase","accession":"P31751","gene":"AKT2","description":"One of the few specific substrates of AKT2 identified recently is PITX2. 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Phosphorylates CLK2 on 'Thr-343'.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.605672671282355,"antibodyCount":1173,"monoclonalCount":318,"pubmedCount":null,"jensenScore":332.48537,"patentCount":36100,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":58.01224160453391,"pubTatorScore":2.450611991435829,"self":"https://pharos.nih.gov/idg/api/v1/targets(17265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/properties"},"_links":{"count":1565,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/links"},"_synonyms":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/synonyms"},"_publications":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(17265)/publications"},"_namespace":null},{"id":17266,"version":2,"created":1554999341000,"modified":1554999345000,"deprecated":false,"name":"Probable fibrosin-1","accession":"Q9HAH7","gene":"FBRS","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6542568351492941,"antibodyCount":33,"monoclonalCount":2,"pubmedCount":null,"jensenScore":42.915079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.761725723660923,"pubTatorScore":1.2382851001502533,"self":"https://pharos.nih.gov/idg/api/v1/targets(17266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17266)/publications"},"_namespace":null},{"id":17267,"version":3,"created":1554999346000,"modified":1555043886000,"deprecated":false,"name":"Calcium uptake protein 1, mitochondrial","accession":"Q9BPX6","gene":"MICU1","description":"Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). 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May also regulate alternative splice site selection (PubMed:20167602).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4000717549200665,"antibodyCount":44,"monoclonalCount":2,"pubmedCount":null,"jensenScore":22.465374,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.066473628230696,"pubTatorScore":1.1993763753088569,"self":"https://pharos.nih.gov/idg/api/v1/targets(17272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/properties"},"_links":{"count":1061,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(17272)/publications"},"_namespace":null},{"id":17273,"version":2,"created":1554999382000,"modified":1554999391000,"deprecated":false,"name":"Growth arrest-specific protein 7","accession":"O60861","gene":"GAS7","description":"May play a role in promoting maturation and morphological differentiation of cerebellar neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4300899331722574,"antibodyCount":241,"monoclonalCount":109,"pubmedCount":null,"jensenScore":28.840142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.14976673049878,"pubTatorScore":1.0995847957578984,"self":"https://pharos.nih.gov/idg/api/v1/targets(17273)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(17273)/publications"},"_namespace":null},{"id":17274,"version":2,"created":1554999392000,"modified":1554999398000,"deprecated":false,"name":"Zinc finger protein 778","accession":"Q96MU6","gene":"ZNF778","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.15126767714020944,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.037684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.07185003096348,"pubTatorScore":0.33579196829410124,"self":"https://pharos.nih.gov/idg/api/v1/targets(17274)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(17274)/publications"},"_namespace":null},{"id":17275,"version":2,"created":1554999400000,"modified":1554999405000,"deprecated":false,"name":"17-beta-hydroxysteroid dehydrogenase 14","accession":"Q9BPX1","gene":"HSD17B14","description":"Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. 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Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.971689076691492,"antibodyCount":355,"monoclonalCount":51,"pubmedCount":null,"jensenScore":906.437874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.674200842704934,"pubTatorScore":2.7922450623421575,"self":"https://pharos.nih.gov/idg/api/v1/targets(17282)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":585,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/properties"},"_links":{"count":1354,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/synonyms"},"_publications":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(17282)/publications"},"_namespace":null},{"id":17283,"version":2,"created":1554999482000,"modified":1554999488000,"deprecated":false,"name":"Very large A-kinase anchor protein","accession":"Q68DQ2","gene":"CRYBG3","description":"Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":2,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.249586974963567,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(17283)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(17283)/publications"},"_namespace":null},{"id":17284,"version":2,"created":1554999489000,"modified":1554999492000,"deprecated":false,"name":"Elongin BC and Polycomb repressive complex 2-associated protein","accession":"A6NHQ4","gene":"EPOP","description":"Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). 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May also bind DNA and function as a transcriptional regulator.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8707660985668774,"antibodyCount":192,"monoclonalCount":26,"pubmedCount":null,"jensenScore":9.729205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":40.73386390961712,"pubTatorScore":0.8314432015240787,"self":"https://pharos.nih.gov/idg/api/v1/targets(17285)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17285)/publications"},"_namespace":null},{"id":17286,"version":2,"created":1554999499000,"modified":1554999507000,"deprecated":false,"name":"Granulocyte-macrophage colony-stimulating factor","accession":"P04141","gene":"CSF2","description":"Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.916819995870023,"antibodyCount":1272,"monoclonalCount":714,"pubmedCount":null,"jensenScore":8450.342257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.12387997061882,"pubTatorScore":3.9534431361487927,"self":"https://pharos.nih.gov/idg/api/v1/targets(17286)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/properties"},"_links":{"count":621,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/synonyms"},"_publications":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(17286)/publications"},"_namespace":null},{"id":17287,"version":3,"created":1554999509000,"modified":1555043896000,"deprecated":false,"name":"DNA polymerase eta","accession":"Q9Y253","gene":"POLH","description":"DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). 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Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with MB21D1/cGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6826990194657392,"antibodyCount":101,"monoclonalCount":12,"pubmedCount":null,"jensenScore":52.962979,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.361857336325656,"pubTatorScore":1.8068326079807928,"self":"https://pharos.nih.gov/idg/api/v1/targets(17377)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":456,"href":"https://pharos.nih.gov/idg/api/v1/targets(17377)/properties"},"_links":{"count":1370,"href":"https://pharos.nih.gov/idg/api/v1/targets(17377)/links"},"_synonyms":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(17377)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(17377)/publications"},"_namespace":null},{"id":17378,"version":3,"created":1555001224000,"modified":1555043951000,"deprecated":false,"name":"Dehydrodolichyl diphosphate synthase complex subunit DHDDS","accession":"Q86SQ9","gene":"DHDDS","description":"With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. 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Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7157698775700525,"antibodyCount":130,"monoclonalCount":10,"pubmedCount":null,"jensenScore":52.129871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":30.543940894048642,"pubTatorScore":1.198032711100216,"self":"https://pharos.nih.gov/idg/api/v1/targets(17381)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(17381)/properties"},"_links":{"count":980,"href":"https://pharos.nih.gov/idg/api/v1/targets(17381)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(17381)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(17381)/publications"},"_namespace":null},{"id":17382,"version":3,"created":1555001249000,"modified":1555043957000,"deprecated":false,"name":"Transmembrane protease serine 11B","accession":"Q86T26","gene":"TMPRSS11B","description":"Serine protease.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":40,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.818182,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":53,"knowledgeAvailability":13.183186928383055,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(17382)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(17382)/properties"},"_links":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(17382)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(17382)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(17382)/publications"},"_namespace":null},{"id":17383,"version":2,"created":1555001252000,"modified":1555001256000,"deprecated":false,"name":"Adhesion G protein-coupled receptor A1","accession":"Q86SQ6","gene":"ADGRA1","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.524311106184533,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.999446,"patentCount":712,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.323624400839414,"pubTatorScore":0.47153519983027764,"self":"https://pharos.nih.gov/idg/api/v1/targets(17383)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(17383)/properties"},"_links":{"count":620,"href":"https://pharos.nih.gov/idg/api/v1/targets(17383)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(17383)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17383)/publications"},"_namespace":null},{"id":17384,"version":2,"created":1555001256000,"modified":1555001260000,"deprecated":false,"name":"DnaJ homolog subfamily C member 21","accession":"Q5F1R6","gene":"DNAJC21","description":"May act as a co-chaperone for HSP70. 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Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0644514227439945,"antibodyCount":121,"monoclonalCount":0,"pubmedCount":null,"jensenScore":117.756005,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.04357806159174,"pubTatorScore":2.039273619043025,"self":"https://pharos.nih.gov/idg/api/v1/targets(17386)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(17386)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(17386)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(17386)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(17386)/publications"},"_namespace":null},{"id":17387,"version":2,"created":1555001274000,"modified":1555001278000,"deprecated":false,"name":"Zinc finger protein 85","accession":"Q03923","gene":"ZNF85","description":"May be a transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.9598360913672416,"antibodyCount":97,"monoclonalCount":81,"pubmedCount":null,"jensenScore":7.794627,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.963599511792275,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(17387)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(17387)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(17387)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(17387)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(17387)/publications"},"_namespace":null},{"id":17388,"version":3,"created":1555001278000,"modified":1555001329000,"deprecated":false,"name":"Sphingosine 1-phosphate receptor 3","accession":"Q99500","gene":"S1PR3","description":"Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). 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Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability (PubMed:28738408, PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, MB21D1/cGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408, PubMed:28759889).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.65657368025251,"antibodyCount":126,"monoclonalCount":4,"pubmedCount":null,"jensenScore":428.170755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.4543703207952174,"self":"https://pharos.nih.gov/idg/api/v1/targets(17499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(17499)/publications"},"_namespace":null},{"id":17500,"version":2,"created":1555002667000,"modified":1555002671000,"deprecated":false,"name":"Zinc finger protein 614","accession":"Q8N883","gene":"ZNF614","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":1.146128035678238,"antibodyCount":102,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.63914900104766,"pubTatorScore":-1.1760890875887005,"self":"https://pharos.nih.gov/idg/api/v1/targets(17500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/properties"},"_links":{"count":817,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(17500)/publications"},"_namespace":null},{"id":17501,"version":2,"created":1555002671000,"modified":1555002675000,"deprecated":false,"name":"Heat shock 70 kDa protein 12B","accession":"Q96MM6","gene":"HSPA12B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9711432559447918,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.035587,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.589952076723335,"pubTatorScore":0.630088748857461,"self":"https://pharos.nih.gov/idg/api/v1/targets(17501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(17501)/publications"},"_namespace":null},{"id":17502,"version":2,"created":1555002676000,"modified":1555002680000,"deprecated":false,"name":"M-phase phosphoprotein 8","accession":"Q99549","gene":"MPHOSPH8","description":"Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). 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Mediates down-regulation of CDH1 expression (PubMed:20871592).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.166440982024961,"antibodyCount":58,"monoclonalCount":8,"pubmedCount":null,"jensenScore":15.546911,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.721617991705386,"pubTatorScore":1.089652794273308,"self":"https://pharos.nih.gov/idg/api/v1/targets(17502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(17502)/publications"},"_namespace":null},{"id":17503,"version":3,"created":1555002680000,"modified":1555044036000,"deprecated":false,"name":"RNA-binding protein 4B","accession":"Q9BQ04","gene":"RBM4B","description":"Required for the translational activation of PER1 mRNA in response to circadian clock. 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Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. 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Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8075923005212315,"antibodyCount":220,"monoclonalCount":19,"pubmedCount":null,"jensenScore":80.275465,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.68267521837803,"pubTatorScore":1.7398363215807648,"self":"https://pharos.nih.gov/idg/api/v1/targets(17696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":300,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(17696)/publications"},"_namespace":null},{"id":17697,"version":2,"created":1555003843000,"modified":1555003844000,"deprecated":false,"name":"Serpin A11","accession":"Q86U17","gene":"SERPINA11","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.30234803816437344,"antibodyCount":64,"monoclonalCount":5,"pubmedCount":null,"jensenScore":0.526165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.91743369965142,"pubTatorScore":-0.3723863384943485,"self":"https://pharos.nih.gov/idg/api/v1/targets(17697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/properties"},"_links":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(17697)/publications"},"_namespace":null},{"id":17698,"version":2,"created":1555003844000,"modified":1555003849000,"deprecated":false,"name":"UDP-N-acetylglucosamine transporter","accession":"Q9Y2D2","gene":"SLC35A3","description":"Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.9294593821295687,"antibodyCount":50,"monoclonalCount":24,"pubmedCount":null,"jensenScore":75.305862,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.9538209710736,"pubTatorScore":1.0543576495492253,"self":"https://pharos.nih.gov/idg/api/v1/targets(17698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(17698)/publications"},"_namespace":null},{"id":17699,"version":2,"created":1555003849000,"modified":1555003856000,"deprecated":false,"name":"Afadin- and alpha-actinin-binding protein","accession":"Q9Y2D8","gene":"SSX2IP","description":"Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5666115208453306,"antibodyCount":120,"monoclonalCount":16,"pubmedCount":null,"jensenScore":37.647358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.742162472154256,"pubTatorScore":1.259370080742152,"self":"https://pharos.nih.gov/idg/api/v1/targets(17699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/properties"},"_links":{"count":991,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(17699)/publications"},"_namespace":null},{"id":17700,"version":2,"created":1555003856000,"modified":1555003861000,"deprecated":false,"name":"Zinc finger protein 652","accession":"Q9Y2D9","gene":"ZNF652","description":"Functions as a transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.704773344397246,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.207875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.23364702727637,"pubTatorScore":0.879079069626115,"self":"https://pharos.nih.gov/idg/api/v1/targets(17700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(17700)/publications"},"_namespace":null},{"id":17701,"version":3,"created":1555003862000,"modified":1555044165000,"deprecated":false,"name":"Voltage-dependent L-type calcium channel subunit beta-1","accession":"Q02641","gene":"CACNB1","description":"The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.9084067908137039,"antibodyCount":294,"monoclonalCount":56,"pubmedCount":null,"jensenScore":6.639103,"patentCount":6179,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":41.039275382887396,"pubTatorScore":0.9817518502084668,"self":"https://pharos.nih.gov/idg/api/v1/targets(17701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":496,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(17701)/publications"},"_namespace":null},{"id":17702,"version":2,"created":1555003867000,"modified":1555003871000,"deprecated":false,"name":"Exocyst complex component 6B","accession":"Q9Y2D4","gene":"EXOC6B","description":"Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7047223355413473,"antibodyCount":48,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.669814,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.648028595542876,"pubTatorScore":0.7229079844338242,"self":"https://pharos.nih.gov/idg/api/v1/targets(17702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(17702)/publications"},"_namespace":null},{"id":17703,"version":2,"created":1555003872000,"modified":1555003875000,"deprecated":false,"name":"A-kinase anchor protein 2","accession":"Q9Y2D5","gene":"PALM2-AKAP2","description":"Binds to regulatory subunit (RII) of protein kinase A. 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During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.467713790540776,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.494054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":27.201495818334394,"pubTatorScore":0.67843160252195,"self":"https://pharos.nih.gov/idg/api/v1/targets(17705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17705)/publications"},"_namespace":null},{"id":17706,"version":2,"created":1555003888000,"modified":1555003892000,"deprecated":false,"name":"Protein broad-minded","accession":"Q96NH3","gene":"TBC1D32","description":"Required for high-level Shh responses in the developing neural tube. 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Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.4276358897689372,"antibodyCount":333,"monoclonalCount":124,"pubmedCount":null,"jensenScore":2.508889,"patentCount":1779,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.08881735048571,"pubTatorScore":0.9034517121861506,"self":"https://pharos.nih.gov/idg/api/v1/targets(17707)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(17707)/publications"},"_namespace":null},{"id":17708,"version":2,"created":1555003900000,"modified":1555003903000,"deprecated":false,"name":"Cytochrome b561 domain-containing protein 1","accession":"Q8N8Q1","gene":"CYB561D1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.027248706234293,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(17708)/publications"},"_namespace":null},{"id":17709,"version":3,"created":1555003904000,"modified":1555044168000,"deprecated":false,"name":"Claudin-10","accession":"P78369","gene":"CLDN10","description":"Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. 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Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). 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Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.7484518107084512,"antibodyCount":341,"monoclonalCount":48,"pubmedCount":null,"jensenScore":537.78783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.94561371241707,"pubTatorScore":2.527328548039641,"self":"https://pharos.nih.gov/idg/api/v1/targets(17796)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":513,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/properties"},"_links":{"count":1037,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/synonyms"},"_publications":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(17796)/publications"},"_namespace":null},{"id":17797,"version":2,"created":1555005058000,"modified":1555005059000,"deprecated":false,"name":"Susceptibility protein NSG-x","accession":"Q9UH64","gene":"CDKN2A-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.507987092933577,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17797)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(17797)/publications"},"_namespace":null},{"id":17798,"version":3,"created":1555005059000,"modified":1555044221000,"deprecated":false,"name":"Sodium-coupled monocarboxylate transporter 2","accession":"Q1EHB4","gene":"SLC5A12","description":"Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. 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Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.6616101298882765,"antibodyCount":10,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.968243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.5830868881201,"pubTatorScore":0.45010231662026934,"self":"https://pharos.nih.gov/idg/api/v1/targets(17798)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(17798)/publications"},"_namespace":null},{"id":17799,"version":2,"created":1555005062000,"modified":1555005066000,"deprecated":false,"name":"Acyloxyacyl hydrolase","accession":"P28039","gene":"AOAH","description":"Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145). 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Involved in glucose-responsive gene regulation.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.383661045142752,"antibodyCount":265,"monoclonalCount":7,"pubmedCount":null,"jensenScore":2368.906221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":38.82789098840238,"pubTatorScore":1.4855411284660105,"self":"https://pharos.nih.gov/idg/api/v1/targets(17874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(17874)/publications"},"_namespace":null},{"id":17875,"version":3,"created":1555006094000,"modified":1555044287000,"deprecated":false,"name":"SUN domain-containing protein 2","accession":"Q9UH99","gene":"SUN2","description":"As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6625960523795016,"antibodyCount":114,"monoclonalCount":9,"pubmedCount":null,"jensenScore":38.416713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":41.945946102763656,"pubTatorScore":1.5045576447549451,"self":"https://pharos.nih.gov/idg/api/v1/targets(17875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/properties"},"_links":{"count":1212,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(17875)/publications"},"_namespace":null},{"id":17876,"version":2,"created":1555006100000,"modified":1555006105000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 5","accession":"P53041","gene":"PPP5C","description":"Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5907470714683236,"antibodyCount":338,"monoclonalCount":175,"pubmedCount":null,"jensenScore":41.938543,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.49084145994729,"pubTatorScore":2.039399951822782,"self":"https://pharos.nih.gov/idg/api/v1/targets(17876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":493,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/properties"},"_links":{"count":1063,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/links"},"_synonyms":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(17876)/publications"},"_namespace":null},{"id":17877,"version":3,"created":1555006107000,"modified":1555044289000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF43","accession":"Q68DV7","gene":"RNF43","description":"E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7004308192895656,"antibodyCount":115,"monoclonalCount":0,"pubmedCount":null,"jensenScore":55.03305,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":37.781423663965924,"pubTatorScore":1.54785483947469,"self":"https://pharos.nih.gov/idg/api/v1/targets(17877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(17877)/publications"},"_namespace":null},{"id":17878,"version":4,"created":1555006114000,"modified":1555044290000,"deprecated":false,"name":"Arachidonate 15-lipoxygenase","accession":"P16050","gene":"ALOX15","description":"Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.437723793733538,"antibodyCount":185,"monoclonalCount":68,"pubmedCount":null,"jensenScore":277.565109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.34952907975855,"pubTatorScore":2.73055456333208,"self":"https://pharos.nih.gov/idg/api/v1/targets(17878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":540,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/properties"},"_links":{"count":1140,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/synonyms"},"_publications":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(17878)/publications"},"_namespace":null},{"id":17879,"version":2,"created":1555006173000,"modified":1555006175000,"deprecated":false,"name":"Protein FAM92A","accession":"A1XBS5","gene":"FAM92A","description":"May play a role in ciliogenesis (PubMed:27528616). 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In addition, may also function as scaffolding protein (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1133310814461512,"antibodyCount":435,"monoclonalCount":84,"pubmedCount":null,"jensenScore":124.397291,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":54.65783103369844,"pubTatorScore":1.632601992409748,"self":"https://pharos.nih.gov/idg/api/v1/targets(17880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":567,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/properties"},"_links":{"count":1290,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/synonyms"},"_publications":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(17880)/publications"},"_namespace":null},{"id":17881,"version":3,"created":1555006185000,"modified":1555044294000,"deprecated":false,"name":"Protein PAT1 homolog 1","accession":"Q86TB9","gene":"PATL1","description":"RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8114260395773512,"antibodyCount":65,"monoclonalCount":1,"pubmedCount":null,"jensenScore":7.84267,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":35.17065984534335,"pubTatorScore":0.8912320619274487,"self":"https://pharos.nih.gov/idg/api/v1/targets(17881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(17881)/publications"},"_namespace":null},{"id":17882,"version":3,"created":1555006192000,"modified":1555044295000,"deprecated":false,"name":"cAMP-dependent protein kinase inhibitor gamma","accession":"Q9Y2B9","gene":"PKIG","description":"Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8196222554530482,"antibodyCount":29,"monoclonalCount":7,"pubmedCount":null,"jensenScore":8.099626,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.097041253098254,"pubTatorScore":0.7781512503836436,"self":"https://pharos.nih.gov/idg/api/v1/targets(17882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(17882)/publications"},"_namespace":null},{"id":17883,"version":2,"created":1555006197000,"modified":1555006197000,"deprecated":false,"name":"Early placenta insulin-like peptide","accession":"Q14641","gene":"INSL4","description":"May play an important role in trophoblast development and in the regulation of bone formation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4238628277087269,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":28.672542,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.400550318524594,"pubTatorScore":1.4028464858979066,"self":"https://pharos.nih.gov/idg/api/v1/targets(17883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/properties"},"_links":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(17883)/publications"},"_namespace":null},{"id":17884,"version":2,"created":1555006197000,"modified":1555006201000,"deprecated":false,"name":"Polyadenylate-binding protein 4","accession":"Q13310","gene":"PABPC4","description":"Binds the poly(A) tail of mRNA. 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Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhbits endoderm differentiation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2802876293802856,"antibodyCount":350,"monoclonalCount":98,"pubmedCount":null,"jensenScore":205.072108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":50.87528359069619,"pubTatorScore":2.296084789162556,"self":"https://pharos.nih.gov/idg/api/v1/targets(17942)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":624,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/properties"},"_links":{"count":1301,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/synonyms"},"_publications":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(17942)/publications"},"_namespace":null},{"id":17943,"version":2,"created":1555006609000,"modified":1555006613000,"deprecated":false,"name":"Protein KIAA0100","accession":"Q14667","gene":"KIAA0100","description":"May be involved in membrane trafficking.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9336559949435908,"antibodyCount":31,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.190476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.18375792586479,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(17943)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(17943)/publications"},"_namespace":null},{"id":17944,"version":2,"created":1555006614000,"modified":1555006619000,"deprecated":false,"name":"Pro-neuregulin-3, membrane-bound isoform","accession":"P56975","gene":"NRG3","description":"Direct ligand for the ERBB4 tyrosine kinase receptor. 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May also play a role in transmembrane water transport, possibly by indirect means.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.0715764930789526,"antibodyCount":101,"monoclonalCount":20,"pubmedCount":null,"jensenScore":116.948898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.25238289892423,"pubTatorScore":2.1203083348647773,"self":"https://pharos.nih.gov/idg/api/v1/targets(17945)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/synonyms"},"_publications":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(17945)/publications"},"_namespace":null},{"id":17946,"version":2,"created":1555006628000,"modified":1555006631000,"deprecated":false,"name":"Zinc finger protein 626","accession":"Q68DY1","gene":"ZNF626","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.69335280954592,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(17946)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(17946)/publications"},"_namespace":null},{"id":17947,"version":3,"created":1555006631000,"modified":1555044348000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DM beta chain","accession":"P28068","gene":"HLA-DMB","description":"Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. 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Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2091745916372774,"antibodyCount":64,"monoclonalCount":3,"pubmedCount":null,"jensenScore":177.867888,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.308848489580637,"pubTatorScore":2.5766573347939437,"self":"https://pharos.nih.gov/idg/api/v1/targets(17948)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/properties"},"_links":{"count":742,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/synonyms"},"_publications":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17948)/publications"},"_namespace":null},{"id":17949,"version":3,"created":1555006643000,"modified":1555044350000,"deprecated":false,"name":"Proteasome subunit alpha type-5","accession":"P28066","gene":"PSMA5","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1667569840073957,"antibodyCount":307,"monoclonalCount":73,"pubmedCount":null,"jensenScore":13.438209,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":27,"knowledgeAvailability":45.7644952803287,"pubTatorScore":1.0492722673163284,"self":"https://pharos.nih.gov/idg/api/v1/targets(17949)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":633,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/properties"},"_links":{"count":1243,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/links"},"_synonyms":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(17949)/publications"},"_namespace":null},{"id":17950,"version":3,"created":1555006652000,"modified":1555044352000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DM alpha chain","accession":"P28067","gene":"HLA-DMA","description":"Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. 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Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1372772376284166,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":136.273898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.237591176520425,"pubTatorScore":1.2168253969052283,"self":"https://pharos.nih.gov/idg/api/v1/targets(17951)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(17951)/publications"},"_namespace":null},{"id":17952,"version":3,"created":1555006664000,"modified":1555044355000,"deprecated":false,"name":"Proteasome subunit beta type-9","accession":"P28065","gene":"PSMB9","description":"The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. 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May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5928250216022373,"antibodyCount":257,"monoclonalCount":93,"pubmedCount":null,"jensenScore":384.926598,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":39.101236574732276,"pubTatorScore":2.288439195680316,"self":"https://pharos.nih.gov/idg/api/v1/targets(17961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(17961)/publications"},"_namespace":null},{"id":17962,"version":2,"created":1555006731000,"modified":1555006733000,"deprecated":false,"name":"Homeobox protein Hox-A4","accession":"Q00056","gene":"HOXA4","description":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. 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May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.902021201592069,"antibodyCount":496,"monoclonalCount":106,"pubmedCount":null,"jensenScore":763.926091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.26551678362893,"pubTatorScore":2.64234344204775,"self":"https://pharos.nih.gov/idg/api/v1/targets(17969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":532,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/synonyms"},"_publications":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(17969)/publications"},"_namespace":null},{"id":17970,"version":2,"created":1555006824000,"modified":1555006827000,"deprecated":false,"name":"Potassium channel subfamily K member 12","accession":"Q9HB15","gene":"KCNK12","description":"Probable potassium channel subunit. 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May need to associate with another protein to form a functional channel (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.7461220797215813,"antibodyCount":102,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.030795,"patentCount":496,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.865569546333365,"pubTatorScore":0.8160186587229207,"self":"https://pharos.nih.gov/idg/api/v1/targets(17970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/properties"},"_links":{"count":686,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(17970)/publications"},"_namespace":null},{"id":17971,"version":2,"created":1555006828000,"modified":1555006833000,"deprecated":false,"name":"Nuclear body protein SP140","accession":"Q13342","gene":"SP140","description":"Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-1.1243837734616466,"antibodyCount":114,"monoclonalCount":22,"pubmedCount":null,"jensenScore":14.162196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.890065610984415,"pubTatorScore":1.0377584270451916,"self":"https://pharos.nih.gov/idg/api/v1/targets(17971)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(17971)/publications"},"_namespace":null},{"id":17972,"version":3,"created":1555006833000,"modified":1555044365000,"deprecated":false,"name":"Separin","accession":"Q14674","gene":"ESPL1","description":"Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4159504798042266,"antibodyCount":535,"monoclonalCount":73,"pubmedCount":null,"jensenScore":262.856135,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.78208066931231,"pubTatorScore":2.080726669699952,"self":"https://pharos.nih.gov/idg/api/v1/targets(17972)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/properties"},"_links":{"count":988,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(17972)/publications"},"_namespace":null},{"id":17973,"version":3,"created":1555006842000,"modified":1555044366000,"deprecated":false,"name":"Methylosome protein 50","accession":"Q9BQA1","gene":"WDR77","description":"Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3811139482884653,"antibodyCount":163,"monoclonalCount":80,"pubmedCount":null,"jensenScore":24.700696,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":40.75046679924489,"pubTatorScore":1.2257314795256935,"self":"https://pharos.nih.gov/idg/api/v1/targets(17973)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(17973)/publications"},"_namespace":null},{"id":17974,"version":2,"created":1555006846000,"modified":1555006850000,"deprecated":false,"name":"MLX-interacting protein","accession":"Q9HAP2","gene":"MLXIP","description":"Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1610718622729959,"antibodyCount":101,"monoclonalCount":4,"pubmedCount":null,"jensenScore":14.509522,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.190388000595625,"pubTatorScore":2.0164937190197545,"self":"https://pharos.nih.gov/idg/api/v1/targets(17974)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(17974)/publications"},"_namespace":null},{"id":17975,"version":3,"created":1555006851000,"modified":1555044368000,"deprecated":false,"name":"Pumilio homolog 1","accession":"Q14671","gene":"PUM1","description":"Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4087092846402554,"antibodyCount":198,"monoclonalCount":8,"pubmedCount":null,"jensenScore":23.627815,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":44.9832565753904,"pubTatorScore":1.416536929897623,"self":"https://pharos.nih.gov/idg/api/v1/targets(17975)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/properties"},"_links":{"count":1113,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(17975)/publications"},"_namespace":null},{"id":17976,"version":2,"created":1555006857000,"modified":1555006861000,"deprecated":false,"name":"Homeobox protein Nkx-2.1","accession":"P43699","gene":"NKX2-1","description":"Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.086313276801531,"antibodyCount":530,"monoclonalCount":328,"pubmedCount":null,"jensenScore":1272.525821,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.82426035853863,"pubTatorScore":2.7959002244224904,"self":"https://pharos.nih.gov/idg/api/v1/targets(17976)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":500,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/synonyms"},"_publications":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(17976)/publications"},"_namespace":null},{"id":17977,"version":2,"created":1555006862000,"modified":1555006867000,"deprecated":false,"name":"NAD kinase","accession":"O95544","gene":"NADK","description":null,"idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.4988026623086184,"antibodyCount":98,"monoclonalCount":7,"pubmedCount":null,"jensenScore":29.788294,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.58195033064426,"pubTatorScore":1.7016159361174552,"self":"https://pharos.nih.gov/idg/api/v1/targets(17977)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(17977)/publications"},"_namespace":null},{"id":17978,"version":2,"created":1555006868000,"modified":1555006874000,"deprecated":false,"name":"KN motif and ankyrin repeat domain-containing protein 1","accession":"Q14678","gene":"KANK1","description":"Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5212151135298895,"antibodyCount":64,"monoclonalCount":21,"pubmedCount":null,"jensenScore":36.613596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.04749073516603,"pubTatorScore":1.3598963551603385,"self":"https://pharos.nih.gov/idg/api/v1/targets(17978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/properties"},"_links":{"count":1181,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(17978)/publications"},"_namespace":null},{"id":17979,"version":3,"created":1555006875000,"modified":1555044369000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit I","accession":"Q13347","gene":"EIF3I","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0725739933368414,"antibodyCount":118,"monoclonalCount":27,"pubmedCount":null,"jensenScore":13.98511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":39.29790553627566,"pubTatorScore":1.3819049404864894,"self":"https://pharos.nih.gov/idg/api/v1/targets(17979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(17979)/publications"},"_namespace":null},{"id":17980,"version":3,"created":1555006880000,"modified":1555044371000,"deprecated":false,"name":"Clathrin interactor 1","accession":"Q14677","gene":"CLINT1","description":"Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2666775220042608,"antibodyCount":151,"monoclonalCount":39,"pubmedCount":null,"jensenScore":179.415926,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":40.945466768159505,"pubTatorScore":1.6448994749676544,"self":"https://pharos.nih.gov/idg/api/v1/targets(17980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":427,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/properties"},"_links":{"count":1215,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(17980)/publications"},"_namespace":null},{"id":17981,"version":3,"created":1555006887000,"modified":1555044373000,"deprecated":false,"name":"Mediator of DNA damage checkpoint protein 1","accession":"Q14676","gene":"MDC1","description":"Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.127625760298927,"antibodyCount":286,"monoclonalCount":95,"pubmedCount":null,"jensenScore":136.368463,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.6772211269631,"pubTatorScore":2.1291903564507138,"self":"https://pharos.nih.gov/idg/api/v1/targets(17981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":549,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/links"},"_synonyms":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(17981)/publications"},"_namespace":null},{"id":17982,"version":2,"created":1555006894000,"modified":1555006899000,"deprecated":false,"name":"Tubulin polyglutamylase TTLL4","accession":"Q14679","gene":"TTLL4","description":"Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5232842181139135,"antibodyCount":111,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.238505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.913826434907634,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(17982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(17982)/publications"},"_namespace":null},{"id":17983,"version":2,"created":1555006900000,"modified":1555006904000,"deprecated":false,"name":"Integrin alpha-D","accession":"Q13349","gene":"ITGAD","description":"Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4350439901113152,"antibodyCount":63,"monoclonalCount":22,"pubmedCount":null,"jensenScore":29.648189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.094822692117802,"pubTatorScore":1.2430167305082267,"self":"https://pharos.nih.gov/idg/api/v1/targets(17983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(17983)/publications"},"_namespace":null},{"id":17984,"version":4,"created":1555006905000,"modified":1555044374000,"deprecated":false,"name":"Proteasome subunit beta type-5","accession":"P28074","gene":"PSMB5","description":"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. 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