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Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.703260678926786,"antibodyCount":142,"monoclonalCount":24,"pubmedCount":null,"jensenScore":51.008308,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.287627768397567,"pubTatorScore":1.4383853731975387,"self":"https://pharos.nih.gov/idg/api/v1/targets(16051)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(16051)/properties"},"_links":{"count":847,"href":"https://pharos.nih.gov/idg/api/v1/targets(16051)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(16051)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(16051)/publications"},"_namespace":null},{"id":16052,"version":3,"created":1554987711000,"modified":1555043092000,"deprecated":false,"name":"Cyclic nucleotide-gated cation channel beta-1","accession":"Q14028","gene":"CNGB1","description":"Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.834815642119581,"antibodyCount":53,"monoclonalCount":1,"pubmedCount":null,"jensenScore":67.977336,"patentCount":2912,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.215443822175807,"pubTatorScore":1.5669749892608003,"self":"https://pharos.nih.gov/idg/api/v1/targets(16052)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":307,"href":"https://pharos.nih.gov/idg/api/v1/targets(16052)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(16052)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(16052)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(16052)/publications"},"_namespace":null},{"id":16053,"version":2,"created":1554987716000,"modified":1554987721000,"deprecated":false,"name":"Protocadherin Fat 3","accession":"Q8TDW7","gene":"FAT3","description":"May play a role in the interactions between neurites derived from specific subsets of neurons during development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5206884847045006,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":32.56212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.730029187260605,"pubTatorScore":0.9776441907110869,"self":"https://pharos.nih.gov/idg/api/v1/targets(16053)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(16053)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(16053)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16053)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(16053)/publications"},"_namespace":null},{"id":16054,"version":3,"created":1554987721000,"modified":1555043093000,"deprecated":false,"name":"Volume-regulated anion channel subunit LRRC8C","accession":"Q8TDW0","gene":"LRRC8C","description":"Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7132104369362119,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.899216,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.08934769431225,"pubTatorScore":0.3679767232525211,"self":"https://pharos.nih.gov/idg/api/v1/targets(16054)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(16054)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(16054)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16054)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(16054)/publications"},"_namespace":null},{"id":16055,"version":2,"created":1554987727000,"modified":1554987729000,"deprecated":false,"name":"GATA-type zinc finger protein 1","accession":"P0C6A0","gene":"ZGLP1","description":"Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. 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Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0673304410651805,"antibodyCount":92,"monoclonalCount":16,"pubmedCount":null,"jensenScore":125.72027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.043867089281505,"pubTatorScore":2.3071342269082282,"self":"https://pharos.nih.gov/idg/api/v1/targets(16058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(16058)/properties"},"_links":{"count":682,"href":"https://pharos.nih.gov/idg/api/v1/targets(16058)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(16058)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(16058)/publications"},"_namespace":null},{"id":16059,"version":2,"created":1554987740000,"modified":1554987742000,"deprecated":false,"name":"von Willebrand factor D and EGF domain-containing protein","accession":"Q8N2E2","gene":"VWDE","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.11058970943065997,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.325714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.7042111188533,"pubTatorScore":-1.414968136468304,"self":"https://pharos.nih.gov/idg/api/v1/targets(16059)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(16059)/properties"},"_links":{"count":715,"href":"https://pharos.nih.gov/idg/api/v1/targets(16059)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(16059)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16059)/publications"},"_namespace":null},{"id":16060,"version":2,"created":1554987743000,"modified":1554987744000,"deprecated":false,"name":"Prosalusin","accession":"Q8N2E6","gene":"TOR2A","description":"Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. 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Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. 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Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.820913759573187,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/properties"},"_links":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16184)/publications"},"_namespace":null},{"id":16185,"version":2,"created":1554988642000,"modified":1554988645000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 35","accession":"Q8N283","gene":"ANKRD35","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.370570291139817,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(16185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16185)/publications"},"_namespace":null},{"id":16186,"version":2,"created":1554988646000,"modified":1554988652000,"deprecated":false,"name":"DmX-like protein 2","accession":"Q8TDJ6","gene":"DMXL2","description":"May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9278345792238878,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.339632,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.836610066278794,"pubTatorScore":0.7235302099464002,"self":"https://pharos.nih.gov/idg/api/v1/targets(16186)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(16186)/publications"},"_namespace":null},{"id":16187,"version":2,"created":1554988653000,"modified":1554988658000,"deprecated":false,"name":"Adenylate cyclase type 3","accession":"O60266","gene":"ADCY3","description":"Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.315926106131338,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":204.354385,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.421213182906875,"pubTatorScore":1.83863038414088,"self":"https://pharos.nih.gov/idg/api/v1/targets(16187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":540,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/properties"},"_links":{"count":1047,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16187)/publications"},"_namespace":null},{"id":16188,"version":3,"created":1554988659000,"modified":1555043168000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5","accession":"O60264","gene":"SMARCA5","description":"Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1272052883612718,"antibodyCount":299,"monoclonalCount":67,"pubmedCount":null,"jensenScore":128.43087,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":48.166223340915515,"pubTatorScore":1.8372589754212278,"self":"https://pharos.nih.gov/idg/api/v1/targets(16188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/properties"},"_links":{"count":1224,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(16188)/publications"},"_namespace":null},{"id":16189,"version":2,"created":1554988667000,"modified":1554988667000,"deprecated":false,"name":"Immunoglobulin heavy variable 1-3","accession":"A0A0C4DH29","gene":"IGHV1-3","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.6567693374641719,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/properties"},"_links":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/links"},"_synonyms":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16189)/publications"},"_namespace":null},{"id":16190,"version":2,"created":1554988668000,"modified":1554988672000,"deprecated":false,"name":"Tyrosine-protein kinase Fes/Fps","accession":"P07332","gene":"FES","description":"Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.050375830257087,"antibodyCount":314,"monoclonalCount":82,"pubmedCount":null,"jensenScore":1109.248117,"patentCount":46744,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.97667468280165,"pubTatorScore":1.6036855387979005,"self":"https://pharos.nih.gov/idg/api/v1/targets(16190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/properties"},"_links":{"count":1173,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/links"},"_synonyms":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16190)/publications"},"_namespace":null},{"id":16191,"version":2,"created":1554988674000,"modified":1554988678000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7","accession":"O60262","gene":"GNG7","description":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7625952181066346,"antibodyCount":63,"monoclonalCount":13,"pubmedCount":null,"jensenScore":5.384426,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.76859876292907,"pubTatorScore":0.7096937849873969,"self":"https://pharos.nih.gov/idg/api/v1/targets(16191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16191)/publications"},"_namespace":null},{"id":16192,"version":3,"created":1554988679000,"modified":1555043170000,"deprecated":false,"name":"E3 ubiquitin-protein ligase parkin","accession":"O60260","gene":"PRKN","description":"Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11590439, PubMed:11431533, PubMed:19229105, PubMed:11590439, PubMed:15728840). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy (PubMed:25621951). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death (PubMed:21376232). Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.9961820114461433,"antibodyCount":533,"monoclonalCount":58,"pubmedCount":null,"jensenScore":1004.071903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":0.0,"pubTatorScore":2.7540931540366342,"self":"https://pharos.nih.gov/idg/api/v1/targets(16192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1121,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/properties"},"_links":{"count":1527,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/links"},"_synonyms":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/synonyms"},"_publications":{"count":639,"href":"https://pharos.nih.gov/idg/api/v1/targets(16192)/publications"},"_namespace":null},{"id":16193,"version":3,"created":1554988691000,"modified":1554988806000,"deprecated":false,"name":"Macrophage colony-stimulating factor 1 receptor","accession":"P07333","gene":"CSF1R","description":"Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.1910871586653395,"antibodyCount":1169,"monoclonalCount":379,"pubmedCount":null,"jensenScore":1432.860331,"patentCount":108131,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.45656650460444,"pubTatorScore":2.7423286609942163,"self":"https://pharos.nih.gov/idg/api/v1/targets(16193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":537,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/properties"},"_links":{"count":1572,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/links"},"_synonyms":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/synonyms"},"_publications":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(16193)/publications"},"_namespace":null},{"id":16194,"version":3,"created":1554988809000,"modified":1554988973000,"deprecated":false,"name":"Cathepsin D","accession":"P07339","gene":"CTSD","description":"Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.470608148623589,"antibodyCount":779,"monoclonalCount":244,"pubmedCount":null,"jensenScore":2866.765427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.567068488215945,"pubTatorScore":3.256582776773943,"self":"https://pharos.nih.gov/idg/api/v1/targets(16194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":717,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/properties"},"_links":{"count":1999,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/synonyms"},"_publications":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(16194)/publications"},"_namespace":null},{"id":16195,"version":3,"created":1554988976000,"modified":1555043173000,"deprecated":false,"name":"ERI1 exoribonuclease 2","accession":"A8K979","gene":"ERI2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.690196085674342,"antibodyCount":93,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.190507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.66667685907862,"pubTatorScore":0.42324587393680785,"self":"https://pharos.nih.gov/idg/api/v1/targets(16195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/properties"},"_links":{"count":822,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(16195)/publications"},"_namespace":null},{"id":16196,"version":2,"created":1554988981000,"modified":1554988981000,"deprecated":false,"name":"Putative inactive cathepsin L-like protein CTSL3P","accession":"Q5NE16","gene":"CTSL3P","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.765452476132514,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16196)/publications"},"_namespace":null},{"id":16197,"version":3,"created":1554988981000,"modified":1555043174000,"deprecated":false,"name":"Phospholipid phosphatase-related protein type 2","accession":"Q96GM1","gene":"PLPPR2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.581818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":0.0,"pubTatorScore":-0.3521829524060615,"self":"https://pharos.nih.gov/idg/api/v1/targets(16197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16197)/publications"},"_namespace":null},{"id":16198,"version":2,"created":1554988984000,"modified":1554988993000,"deprecated":false,"name":"Keratin, type I cytoskeletal 17","accession":"Q04695","gene":"KRT17","description":"Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial \"stem cells\". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4390931379312804,"antibodyCount":711,"monoclonalCount":361,"pubmedCount":null,"jensenScore":265.841808,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.98857871116356,"pubTatorScore":2.415362191456079,"self":"https://pharos.nih.gov/idg/api/v1/targets(16198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/properties"},"_links":{"count":1068,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(16198)/publications"},"_namespace":null},{"id":16199,"version":3,"created":1554988995000,"modified":1555043176000,"deprecated":false,"name":"Vascular cell adhesion protein 1","accession":"P19320","gene":"VCAM1","description":"Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. 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Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.644916454602587,"antibodyCount":546,"monoclonalCount":313,"pubmedCount":null,"jensenScore":489.625849,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":64,"knowledgeAvailability":26.262544195012186,"pubTatorScore":2.404913513464373,"self":"https://pharos.nih.gov/idg/api/v1/targets(16215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/properties"},"_links":{"count":1123,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/synonyms"},"_publications":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(16215)/publications"},"_namespace":null},{"id":16216,"version":2,"created":1554989373000,"modified":1554989377000,"deprecated":false,"name":"CMRF35-like molecule 1","accession":"Q8TDQ1","gene":"CD300LF","description":"Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5816067209276758,"antibodyCount":183,"monoclonalCount":52,"pubmedCount":null,"jensenScore":43.395692,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.11905265795739,"pubTatorScore":1.281943703289339,"self":"https://pharos.nih.gov/idg/api/v1/targets(16216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(16216)/publications"},"_namespace":null},{"id":16217,"version":2,"created":1554989378000,"modified":1554989381000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 18 homolog","accession":"Q9P253","gene":"VPS18","description":"Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9250472239873722,"antibodyCount":117,"monoclonalCount":69,"pubmedCount":null,"jensenScore":80.913408,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.460545448013086,"pubTatorScore":1.335481751126337,"self":"https://pharos.nih.gov/idg/api/v1/targets(16217)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/properties"},"_links":{"count":1022,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(16217)/publications"},"_namespace":null},{"id":16218,"version":2,"created":1554989382000,"modified":1554989384000,"deprecated":false,"name":"Keratin-associated protein 5-1","accession":"Q6L8H4","gene":"KRTAP5-1","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.45,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.126896280097545,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16218)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(16218)/properties"},"_links":{"count":630,"href":"https://pharos.nih.gov/idg/api/v1/targets(16218)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(16218)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16218)/publications"},"_namespace":null},{"id":16219,"version":2,"created":1554989384000,"modified":1554989387000,"deprecated":false,"name":"Glucosamine-6-phosphate isomerase 2","accession":"Q8TDQ7","gene":"GNPDA2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.308483635134573,"antibodyCount":79,"monoclonalCount":3,"pubmedCount":null,"jensenScore":20.055529,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.982367176996334,"pubTatorScore":1.3832511526020776,"self":"https://pharos.nih.gov/idg/api/v1/targets(16219)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(16219)/properties"},"_links":{"count":909,"href":"https://pharos.nih.gov/idg/api/v1/targets(16219)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(16219)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(16219)/publications"},"_namespace":null},{"id":16220,"version":2,"created":1554989388000,"modified":1554989391000,"deprecated":false,"name":"Zinc finger protein 492","accession":"Q9P255","gene":"ZNF492","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.470588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.69059123885565,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16220)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(16220)/properties"},"_links":{"count":732,"href":"https://pharos.nih.gov/idg/api/v1/targets(16220)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(16220)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16220)/publications"},"_namespace":null},{"id":16221,"version":3,"created":1554989392000,"modified":1555043195000,"deprecated":false,"name":"X antigen family member 2","accession":"Q96GT9","gene":"XAGE2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.09796157197081,"antibodyCount":66,"monoclonalCount":8,"pubmedCount":null,"jensenScore":12.094758,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":5.431660782939704,"pubTatorScore":0.37599464873680855,"self":"https://pharos.nih.gov/idg/api/v1/targets(16221)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(16221)/properties"},"_links":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(16221)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(16221)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(16221)/publications"},"_namespace":null},{"id":16222,"version":2,"created":1554989392000,"modified":1554989397000,"deprecated":false,"name":"MyoD family inhibitor domain-containing protein","accession":"Q9P1T7","gene":"MDFIC","description":"Acts as a transcriptional activator or repressor. 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Affects axin regulation of the WNT and JNK signaling pathways.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9096890305750778,"antibodyCount":122,"monoclonalCount":0,"pubmedCount":null,"jensenScore":748.988971,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.594925049000295,"pubTatorScore":1.83486204175448,"self":"https://pharos.nih.gov/idg/api/v1/targets(16222)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(16222)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(16222)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(16222)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16222)/publications"},"_namespace":null},{"id":16223,"version":2,"created":1554989398000,"modified":1554989403000,"deprecated":false,"name":"Protein RCC2","accession":"Q9P258","gene":"RCC2","description":"Required for completion of mitosis and cytokinesis. 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TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-2.0340268531875996,"antibodyCount":150,"monoclonalCount":2,"pubmedCount":null,"jensenScore":100.392668,"patentCount":48942,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.236495919312024,"pubTatorScore":1.783341990716743,"self":"https://pharos.nih.gov/idg/api/v1/targets(16224)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(16224)/properties"},"_links":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(16224)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(16224)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(16224)/publications"},"_namespace":null},{"id":16225,"version":2,"created":1554989407000,"modified":1554989408000,"deprecated":false,"name":"Keratin-associated protein 5-4","accession":"Q6L8H1","gene":"KRTAP5-4","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3357921033708414,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.15,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.914228160094778,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16225)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(16225)/properties"},"_links":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(16225)/links"},"_synonyms":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(16225)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(16225)/publications"},"_namespace":null},{"id":16226,"version":2,"created":1554989408000,"modified":1554989408000,"deprecated":false,"name":"Histone H2A-Bbd type 2/3","accession":"P0C5Z0","gene":"H2AFB3","description":"Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. 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May participate in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.25594219427177656,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.359241,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.364844179496641,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(16226)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(16226)/properties"},"_links":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(16226)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(16226)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(16226)/publications"},"_namespace":null},{"id":16227,"version":3,"created":1554989408000,"modified":1555043196000,"deprecated":false,"name":"Unconventional myosin-XIX","accession":"Q96H55","gene":"MYO19","description":"Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9129302512214211,"antibodyCount":113,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.818452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.40485581127905,"pubTatorScore":0.7146091107142875,"self":"https://pharos.nih.gov/idg/api/v1/targets(16227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(16227)/properties"},"_links":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(16227)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(16227)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(16227)/publications"},"_namespace":null},{"id":16228,"version":2,"created":1554989412000,"modified":1554989412000,"deprecated":false,"name":"Keratin-associated protein 5-3","accession":"Q6L8H2","gene":"KRTAP5-3","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. 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Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(16229)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(16229)/links"},"_synonyms":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(16229)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16229)/publications"},"_namespace":null},{"id":16230,"version":2,"created":1554989413000,"modified":1554989413000,"deprecated":false,"name":"Immunoglobulin heavy variable 3-66","accession":"A0A0C4DH42","gene":"IGHV3-66","description":"V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.069756278281265,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/properties"},"_links":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16264)/publications"},"_namespace":null},{"id":16265,"version":3,"created":1554990183000,"modified":1555043212000,"deprecated":false,"name":"Fibroblast growth factor 17","accession":"O60258","gene":"FGF17","description":"Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. 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The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2815833687656488,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/properties"},"_links":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16266)/publications"},"_namespace":null},{"id":16267,"version":3,"created":1554990188000,"modified":1555043213000,"deprecated":false,"name":"Kallikrein-8","accession":"O60259","gene":"KLK8","description":"Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. 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Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.080691740226718,"antibodyCount":263,"monoclonalCount":100,"pubmedCount":null,"jensenScore":1155.025184,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.110626681456345,"pubTatorScore":2.539436610603532,"self":"https://pharos.nih.gov/idg/api/v1/targets(16315)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":642,"href":"https://pharos.nih.gov/idg/api/v1/targets(16315)/properties"},"_links":{"count":1380,"href":"https://pharos.nih.gov/idg/api/v1/targets(16315)/links"},"_synonyms":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(16315)/synonyms"},"_publications":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(16315)/publications"},"_namespace":null},{"id":16316,"version":2,"created":1554990555000,"modified":1554990555000,"deprecated":false,"name":"Immunoglobulin kappa variable 1-8","accession":"A0A0C4DH67","gene":"IGKV1-8","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.2653879042642236,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16316)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(16316)/properties"},"_links":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(16316)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(16316)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16316)/publications"},"_namespace":null},{"id":16317,"version":3,"created":1554990555000,"modified":1555043242000,"deprecated":false,"name":"Mitochondrial import inner membrane translocase subunit Tim8 A","accession":"O60220","gene":"TIMM8A","description":"Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1893045262183857,"antibodyCount":81,"monoclonalCount":35,"pubmedCount":null,"jensenScore":156.802581,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":37.262297602461054,"pubTatorScore":1.977770757966693,"self":"https://pharos.nih.gov/idg/api/v1/targets(16317)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(16317)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(16317)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16317)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(16317)/publications"},"_namespace":null},{"id":16318,"version":3,"created":1554990559000,"modified":1555043245000,"deprecated":false,"name":"Extracellular matrix protein 1","accession":"Q16610","gene":"ECM1","description":"Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1165094777393634,"antibodyCount":234,"monoclonalCount":116,"pubmedCount":null,"jensenScore":134.095508,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":35.49211510518694,"pubTatorScore":2.0967271712911657,"self":"https://pharos.nih.gov/idg/api/v1/targets(16318)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(16318)/properties"},"_links":{"count":1082,"href":"https://pharos.nih.gov/idg/api/v1/targets(16318)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(16318)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(16318)/publications"},"_namespace":null},{"id":16319,"version":2,"created":1554990565000,"modified":1554990574000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 1B","accession":"P20333","gene":"TNFRSF1B","description":"Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.674812849876346,"antibodyCount":712,"monoclonalCount":295,"pubmedCount":null,"jensenScore":4484.728183,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.22466582690768,"pubTatorScore":2.8814784468315433,"self":"https://pharos.nih.gov/idg/api/v1/targets(16319)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(16319)/properties"},"_links":{"count":1337,"href":"https://pharos.nih.gov/idg/api/v1/targets(16319)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(16319)/synonyms"},"_publications":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(16319)/publications"},"_namespace":null},{"id":16320,"version":2,"created":1554990576000,"modified":1554990579000,"deprecated":false,"name":"Protein NKG7","accession":"Q16617","gene":"NKG7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9668944817896815,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.713767,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.286990260824236,"pubTatorScore":1.050288904574279,"self":"https://pharos.nih.gov/idg/api/v1/targets(16320)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(16320)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(16320)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(16320)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16320)/publications"},"_namespace":null},{"id":16321,"version":2,"created":1554990579000,"modified":1554990581000,"deprecated":false,"name":"BAH and coiled-coil domain-containing protein 1","accession":"Q9P281","gene":"BAHCC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.0015409599942,"pubTatorScore":-0.1760916933503803,"self":"https://pharos.nih.gov/idg/api/v1/targets(16321)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(16321)/properties"},"_links":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(16321)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(16321)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(16321)/publications"},"_namespace":null},{"id":16322,"version":2,"created":1554990581000,"modified":1554990585000,"deprecated":false,"name":"Bcl-2 homologous antagonist/killer","accession":"Q16611","gene":"BAK1","description":"In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. 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May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.076502112510151,"antibodyCount":528,"monoclonalCount":167,"pubmedCount":null,"jensenScore":1308.136956,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":58.25867213764624,"pubTatorScore":2.9362901680474502,"self":"https://pharos.nih.gov/idg/api/v1/targets(16327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":728,"href":"https://pharos.nih.gov/idg/api/v1/targets(16327)/properties"},"_links":{"count":1964,"href":"https://pharos.nih.gov/idg/api/v1/targets(16327)/links"},"_synonyms":{"count":578,"href":"https://pharos.nih.gov/idg/api/v1/targets(16327)/synonyms"},"_publications":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(16327)/publications"},"_namespace":null},{"id":16328,"version":3,"created":1554990793000,"modified":1555043255000,"deprecated":false,"name":"Serine/threonine-protein kinase PAK 5","accession":"Q9P286","gene":"PAK5","description":"Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. 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Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.5105922570674293,"antibodyCount":275,"monoclonalCount":4,"pubmedCount":null,"jensenScore":36.137486,"patentCount":9430,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":0.0,"pubTatorScore":1.4058797894146053,"self":"https://pharos.nih.gov/idg/api/v1/targets(16328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(16328)/properties"},"_links":{"count":748,"href":"https://pharos.nih.gov/idg/api/v1/targets(16328)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(16328)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(16328)/publications"},"_namespace":null},{"id":16329,"version":3,"created":1554990800000,"modified":1555043257000,"deprecated":false,"name":"RUS1 family protein C16orf58","accession":"Q96GQ5","gene":"C16orf58","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.934920964657101,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":856.153391,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":0.0,"pubTatorScore":0.7403626894942439,"self":"https://pharos.nih.gov/idg/api/v1/targets(16329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(16329)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(16329)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(16329)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(16329)/publications"},"_namespace":null},{"id":16330,"version":3,"created":1554990804000,"modified":1555043258000,"deprecated":false,"name":"CDK5 and ABL1 enzyme substrate 1","accession":"Q8TDN4","gene":"CABLES1","description":"Cyclin-dependent kinase binding protein. 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Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. 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Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8875637224721943,"antibodyCount":80,"monoclonalCount":19,"pubmedCount":null,"jensenScore":6.96827,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.5944198767325,"pubTatorScore":0.7465567506327095,"self":"https://pharos.nih.gov/idg/api/v1/targets(16346)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(16346)/publications"},"_namespace":null},{"id":16347,"version":3,"created":1554991484000,"modified":1555043270000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily V member 2","accession":"Q8TDN2","gene":"KCNV2","description":"Potassium channel subunit. 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May function as a tumor suppressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2083746052952593,"antibodyCount":355,"monoclonalCount":34,"pubmedCount":null,"jensenScore":153.650971,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.9032821033798,"pubTatorScore":1.9905985633745296,"self":"https://pharos.nih.gov/idg/api/v1/targets(16348)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(16348)/properties"},"_links":{"count":1116,"href":"https://pharos.nih.gov/idg/api/v1/targets(16348)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(16348)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(16348)/publications"},"_namespace":null},{"id":16349,"version":2,"created":1554991501000,"modified":1554991501000,"deprecated":false,"name":"Immunoglobulin kappa variable 3D-7","accession":"A0A0C4DH55","gene":"IGKV3D-7","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.18272303575635598,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16349)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(16349)/properties"},"_links":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(16349)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(16349)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16349)/publications"},"_namespace":null},{"id":16350,"version":2,"created":1554991501000,"modified":1554991507000,"deprecated":false,"name":"SH3 domain-binding protein 5","accession":"O60239","gene":"SH3BP5","description":"Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. 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Augments Ca(2+) sensitivity of the contractile apparatus.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2346667934054867,"antibodyCount":38,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.805206,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":40.873876529210136,"pubTatorScore":1.0696563700624069,"self":"https://pharos.nih.gov/idg/api/v1/targets(16351)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(16351)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(16351)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(16351)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(16351)/publications"},"_namespace":null},{"id":16352,"version":3,"created":1554991514000,"modified":1555043274000,"deprecated":false,"name":"Glia maturation factor gamma","accession":"O60234","gene":"GMFG","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9256312815355845,"antibodyCount":119,"monoclonalCount":10,"pubmedCount":null,"jensenScore":12.774093,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.039936290896513,"pubTatorScore":1.0061603025879946,"self":"https://pharos.nih.gov/idg/api/v1/targets(16352)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(16352)/properties"},"_links":{"count":934,"href":"https://pharos.nih.gov/idg/api/v1/targets(16352)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(16352)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16352)/publications"},"_namespace":null},{"id":16353,"version":2,"created":1554991519000,"modified":1554991524000,"deprecated":false,"name":"Disks large homolog 5","accession":"Q8TDM6","gene":"DLG5","description":"Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7155322680976963,"antibodyCount":60,"monoclonalCount":19,"pubmedCount":null,"jensenScore":56.205963,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.63731788634075,"pubTatorScore":1.8468193504118877,"self":"https://pharos.nih.gov/idg/api/v1/targets(16353)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(16353)/publications"},"_namespace":null},{"id":16354,"version":3,"created":1554991525000,"modified":1555043276000,"deprecated":false,"name":"Histone H2A-Bbd type 1","accession":"P0C5Y9","gene":"H2AFB1","description":"Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). 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They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9493900088163852,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.00875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":12.336503288548355,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(16354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/properties"},"_links":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(16354)/publications"},"_namespace":null},{"id":16355,"version":2,"created":1554991526000,"modified":1554991538000,"deprecated":false,"name":"Transmembrane protease serine 11D","accession":"O60235","gene":"TMPRSS11D","description":"May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3008346071062538,"antibodyCount":97,"monoclonalCount":6,"pubmedCount":null,"jensenScore":201.832324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.414500262956416,"pubTatorScore":1.632119696983063,"self":"https://pharos.nih.gov/idg/api/v1/targets(16355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/properties"},"_links":{"count":648,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(16355)/publications"},"_namespace":null},{"id":16356,"version":3,"created":1554991539000,"modified":1555043278000,"deprecated":false,"name":"Sjoegren syndrome/scleroderma autoantigen 1","accession":"O60232","gene":"SSSCA1","description":"Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. 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Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.60045433640755,"antibodyCount":159,"monoclonalCount":25,"pubmedCount":null,"jensenScore":409.463577,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.96088434817873,"pubTatorScore":2.4701307484798543,"self":"https://pharos.nih.gov/idg/api/v1/targets(16357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(16357)/publications"},"_namespace":null},{"id":16358,"version":2,"created":1554991549000,"modified":1554991554000,"deprecated":false,"name":"Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16","accession":"O60231","gene":"DHX16","description":"Probable ATP-binding RNA helicase involved in pre-mRNA splicing.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5197995371278126,"antibodyCount":78,"monoclonalCount":12,"pubmedCount":null,"jensenScore":31.371154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.20809997043004,"pubTatorScore":1.3530994742300868,"self":"https://pharos.nih.gov/idg/api/v1/targets(16358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/properties"},"_links":{"count":1034,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16358)/publications"},"_namespace":null},{"id":16359,"version":4,"created":1554991554000,"modified":1555043279000,"deprecated":false,"name":"Calpain-1 catalytic subunit","accession":"P07384","gene":"CAPN1","description":"Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.573734420348854,"antibodyCount":338,"monoclonalCount":73,"pubmedCount":null,"jensenScore":361.880383,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":45.433732834792366,"pubTatorScore":2.3691450931960314,"self":"https://pharos.nih.gov/idg/api/v1/targets(16359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":584,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/properties"},"_links":{"count":1626,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/synonyms"},"_publications":{"count":167,"href":"https://pharos.nih.gov/idg/api/v1/targets(16359)/publications"},"_namespace":null},{"id":16360,"version":2,"created":1554991667000,"modified":1554991685000,"deprecated":false,"name":"BDNF/NT-3 growth factors receptor","accession":"Q16620","gene":"NTRK2","description":"Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. 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PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.1447656216494635,"antibodyCount":947,"monoclonalCount":147,"pubmedCount":null,"jensenScore":1170.253701,"patentCount":64967,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.94212778699589,"pubTatorScore":2.7781488299089863,"self":"https://pharos.nih.gov/idg/api/v1/targets(16360)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":665,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/properties"},"_links":{"count":1379,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/links"},"_synonyms":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/synonyms"},"_publications":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(16360)/publications"},"_namespace":null},{"id":16361,"version":2,"created":1554991687000,"modified":1554991688000,"deprecated":false,"name":"Putative speedy protein E16","accession":"A6NNV3","gene":"SPDYE16","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/properties"},"_links":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16361)/publications"},"_namespace":null},{"id":16362,"version":2,"created":1554991688000,"modified":1554991692000,"deprecated":false,"name":"Ras-related protein Rab-6A","accession":"P20340","gene":"RAB6A","description":"Protein transport. 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Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from 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Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. 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Required for efficient DNA double-stranded break repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4344867641325763,"antibodyCount":74,"monoclonalCount":4,"pubmedCount":null,"jensenScore":28.747579,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.09327100911283,"pubTatorScore":1.2697295237649102,"self":"https://pharos.nih.gov/idg/api/v1/targets(16553)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(16553)/publications"},"_namespace":null},{"id":16554,"version":2,"created":1554992898000,"modified":1554992906000,"deprecated":false,"name":"Solute carrier family 22 member 8","accession":"Q8TCC7","gene":"SLC22A8","description":"Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. 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Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).","idgFamily":"Transporter","idgTDL":"Tclin","novelty":-2.4012630996424194,"antibodyCount":113,"monoclonalCount":9,"pubmedCount":null,"jensenScore":258.380271,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.486382914791243,"pubTatorScore":2.0865695549419674,"self":"https://pharos.nih.gov/idg/api/v1/targets(16554)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/properties"},"_links":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(16554)/publications"},"_namespace":null},{"id":16555,"version":2,"created":1554992906000,"modified":1554992917000,"deprecated":false,"name":"Cytosolic phospholipase A2 beta","accession":"P0C869","gene":"JMJD7-PLA2G4B","description":"Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. 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Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.5004476245341856,"antibodyCount":1417,"monoclonalCount":395,"pubmedCount":null,"jensenScore":306.839049,"patentCount":33607,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":65.9434354928749,"pubTatorScore":3.4574370557013787,"self":"https://pharos.nih.gov/idg/api/v1/targets(16557)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(16557)/properties"},"_links":{"count":1642,"href":"https://pharos.nih.gov/idg/api/v1/targets(16557)/links"},"_synonyms":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(16557)/synonyms"},"_publications":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(16557)/publications"},"_namespace":null},{"id":16558,"version":2,"created":1554993016000,"modified":1554993016000,"deprecated":false,"name":"Protein FAM87A","accession":"P0C7U9","gene":"FAM87A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.8289744566814963,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16558)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(16558)/properties"},"_links":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(16558)/links"},"_synonyms":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(16558)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16558)/publications"},"_namespace":null},{"id":16559,"version":2,"created":1554993016000,"modified":1554993019000,"deprecated":false,"name":"Polyamine-modulated factor 1-binding protein 1","accession":"Q8TBY8","gene":"PMFBP1","description":"May play a role in sperm morphology especially the sperm tail and consequently affect fertility. 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Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). 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Able to phosphorylate RPS6 in vitro.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.0336831762453245,"antibodyCount":153,"monoclonalCount":26,"pubmedCount":null,"jensenScore":117.595116,"patentCount":23344,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.69519919186985,"pubTatorScore":1.8483276563925464,"self":"https://pharos.nih.gov/idg/api/v1/targets(16716)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/properties"},"_links":{"count":1139,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(16716)/publications"},"_namespace":null},{"id":16717,"version":3,"created":1554993768000,"modified":1555043452000,"deprecated":false,"name":"Transcription factor E2F3","accession":"O00716","gene":"E2F3","description":"Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. 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Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2700499772397453,"antibodyCount":259,"monoclonalCount":88,"pubmedCount":null,"jensenScore":133.328873,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.700593693206216,"pubTatorScore":2.1474242304649587,"self":"https://pharos.nih.gov/idg/api/v1/targets(16717)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(16717)/publications"},"_namespace":null},{"id":16718,"version":4,"created":1554993774000,"modified":1555043454000,"deprecated":false,"name":"Microsomal triglyceride transfer protein large subunit","accession":"P55157","gene":"MTTP","description":"Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). 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Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.0126363274643295,"antibodyCount":159,"monoclonalCount":41,"pubmedCount":null,"jensenScore":103.648019,"patentCount":16204,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.22446806559992,"pubTatorScore":1.6102375529304491,"self":"https://pharos.nih.gov/idg/api/v1/targets(16719)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(16719)/publications"},"_namespace":null},{"id":16720,"version":3,"created":1554993847000,"modified":1555043457000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 12","accession":"Q16514","gene":"TAF12","description":"TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1416002103977902,"antibodyCount":119,"monoclonalCount":14,"pubmedCount":null,"jensenScore":12.436943,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":33,"knowledgeAvailability":37.31788154844032,"pubTatorScore":1.1971164051537904,"self":"https://pharos.nih.gov/idg/api/v1/targets(16720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(16720)/publications"},"_namespace":null},{"id":16721,"version":2,"created":1554993851000,"modified":1554993855000,"deprecated":false,"name":"Acid-sensing ion channel 2","accession":"Q16515","gene":"ASIC2","description":"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-2.4968278440078837,"antibodyCount":140,"monoclonalCount":3,"pubmedCount":null,"jensenScore":295.786194,"patentCount":25126,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.632494352431756,"pubTatorScore":1.8274974808662123,"self":"https://pharos.nih.gov/idg/api/v1/targets(16721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/properties"},"_links":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(16721)/publications"},"_namespace":null},{"id":16722,"version":2,"created":1554993856000,"modified":1554993858000,"deprecated":false,"name":"Protein LKAAEAR1","accession":"Q8TD35","gene":"LKAAEAR1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":39,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.751811769301662,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(16722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/properties"},"_links":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16722)/publications"},"_namespace":null},{"id":16723,"version":2,"created":1554993859000,"modified":1554993861000,"deprecated":false,"name":"Putative uncharacterized protein C6orf52","accession":"Q5T4I8","gene":"C6orf52","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(16723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/properties"},"_links":{"count":741,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16723)/publications"},"_namespace":null},{"id":16724,"version":2,"created":1554993861000,"modified":1554993864000,"deprecated":false,"name":"Basic leucine zipper transcriptional factor ATF-like","accession":"Q16520","gene":"BATF","description":"AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. 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Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. 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Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0755627422035328,"antibodyCount":127,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.179687,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.092849113977245,"pubTatorScore":0.8044801891059927,"self":"https://pharos.nih.gov/idg/api/v1/targets(16726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(16726)/publications"},"_namespace":null},{"id":16727,"version":3,"created":1554993872000,"modified":1555043458000,"deprecated":false,"name":"Netrin receptor DCC","accession":"P43146","gene":"DCC","description":"Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.055738479520367,"antibodyCount":222,"monoclonalCount":33,"pubmedCount":null,"jensenScore":103.630499,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":44.138854780919054,"pubTatorScore":2.5808521209403286,"self":"https://pharos.nih.gov/idg/api/v1/targets(16727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":394,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(16727)/publications"},"_namespace":null},{"id":16728,"version":2,"created":1554993878000,"modified":1554993882000,"deprecated":false,"name":"Disks large-associated protein 2","accession":"Q9P1A6","gene":"DLGAP2","description":"May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3406053613966402,"antibodyCount":54,"monoclonalCount":1,"pubmedCount":null,"jensenScore":22.602093,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.48503863564657,"pubTatorScore":1.3644626266660633,"self":"https://pharos.nih.gov/idg/api/v1/targets(16728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(16728)/publications"},"_namespace":null},{"id":16729,"version":3,"created":1554993882000,"modified":1555043460000,"deprecated":false,"name":"F-box/LRR-repeat protein 19","accession":"Q6PCT2","gene":"FBXL19","description":"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6058961391703037,"antibodyCount":81,"monoclonalCount":4,"pubmedCount":null,"jensenScore":4.228856,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":32.60935569018493,"pubTatorScore":0.4057116764783553,"self":"https://pharos.nih.gov/idg/api/v1/targets(16729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(16729)/publications"},"_namespace":null},{"id":16730,"version":2,"created":1554993886000,"modified":1554993891000,"deprecated":false,"name":"Cysteine and glycine-rich protein 2","accession":"Q16527","gene":"CSRP2","description":"Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. 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By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0881065793930733,"antibodyCount":133,"monoclonalCount":22,"pubmedCount":null,"jensenScore":122.348666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.454041931998745,"pubTatorScore":3.0848517687953922,"self":"https://pharos.nih.gov/idg/api/v1/targets(16732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(16732)/publications"},"_namespace":null},{"id":16733,"version":3,"created":1554993903000,"modified":1555043463000,"deprecated":false,"name":"Sideroflexin-5","accession":"Q8TD22","gene":"SFXN5","description":"Transports citrate. Potential iron transporter (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.35364233300200976,"antibodyCount":33,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.186147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":30.318097561379428,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(16733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/properties"},"_links":{"count":979,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(16733)/publications"},"_namespace":null},{"id":16734,"version":3,"created":1554993907000,"modified":1555043464000,"deprecated":false,"name":"Cryptochrome-1","accession":"Q16526","gene":"CRY1","description":"Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.619692862178446,"antibodyCount":180,"monoclonalCount":41,"pubmedCount":null,"jensenScore":400.803917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":41.75292067674953,"pubTatorScore":2.1053683908751215,"self":"https://pharos.nih.gov/idg/api/v1/targets(16734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":484,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16734)/publications"},"_namespace":null},{"id":16735,"version":2,"created":1554993913000,"modified":1554993918000,"deprecated":false,"name":"S-adenosylmethionine synthase isoform type-2","accession":"P31153","gene":"MAT2A","description":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9196892488114052,"antibodyCount":242,"monoclonalCount":54,"pubmedCount":null,"jensenScore":84.105088,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.46065699131382,"pubTatorScore":1.7746902620909737,"self":"https://pharos.nih.gov/idg/api/v1/targets(16735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(16735)/publications"},"_namespace":null},{"id":16736,"version":3,"created":1554993919000,"modified":1555043466000,"deprecated":false,"name":"Intraflagellar transport protein 43 homolog","accession":"Q96FT9","gene":"IFT43","description":"Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.224275259852618,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":144.116613,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":29.734099418257564,"pubTatorScore":1.554441051805542,"self":"https://pharos.nih.gov/idg/api/v1/targets(16736)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(16736)/publications"},"_namespace":null},{"id":16737,"version":3,"created":1554993924000,"modified":1555043467000,"deprecated":false,"name":"Mitogen-activated protein kinase 4","accession":"P31152","gene":"MAPK4","description":"Atypical MAPK protein. 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May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5502336579945906,"antibodyCount":74,"monoclonalCount":0,"pubmedCount":null,"jensenScore":35.117995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.617940749210447,"pubTatorScore":0.5440680443502757,"self":"https://pharos.nih.gov/idg/api/v1/targets(16738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16738)/publications"},"_namespace":null},{"id":16739,"version":3,"created":1554993933000,"modified":1555043470000,"deprecated":false,"name":"Acid-sensing ion channel 4","accession":"Q96FT7","gene":"ASIC4","description":"Probable cation channel with high affinity for sodium. 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Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.623028160524211,"antibodyCount":77,"monoclonalCount":1,"pubmedCount":null,"jensenScore":45.328097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.818232661644466,"pubTatorScore":1.3374191645744546,"self":"https://pharos.nih.gov/idg/api/v1/targets(16741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(16741)/publications"},"_namespace":null},{"id":16742,"version":2,"created":1554993950000,"modified":1554993956000,"deprecated":false,"name":"HLA class I histocompatibility antigen, B-67 alpha chain","accession":"Q29836","gene":"HLA-B","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8875247029897861,"antibodyCount":362,"monoclonalCount":184,"pubmedCount":null,"jensenScore":1613.472112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.7801564385417628,"self":"https://pharos.nih.gov/idg/api/v1/targets(16742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1932,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/properties"},"_links":{"count":1505,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/synonyms"},"_publications":{"count":1770,"href":"https://pharos.nih.gov/idg/api/v1/targets(16742)/publications"},"_namespace":null},{"id":16743,"version":2,"created":1554993960000,"modified":1554993974000,"deprecated":false,"name":"2-5A-dependent ribonuclease","accession":"Q05823","gene":"RNASEL","description":"Endoribonuclease that functions in the interferon (IFN) antiviral response. 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Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.716730439757016,"antibodyCount":127,"monoclonalCount":48,"pubmedCount":null,"jensenScore":525.762681,"patentCount":24366,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.728602939990466,"pubTatorScore":2.5989202047021496,"self":"https://pharos.nih.gov/idg/api/v1/targets(16743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":534,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(16743)/publications"},"_namespace":null},{"id":16744,"version":3,"created":1554993976000,"modified":1555043471000,"deprecated":false,"name":"Protrudin","accession":"Q5T4F4","gene":"ZFYVE27","description":"Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). 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The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3471939830197788,"antibodyCount":353,"monoclonalCount":77,"pubmedCount":null,"jensenScore":202.523473,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.97512941627025,"pubTatorScore":2.1159342282522915,"self":"https://pharos.nih.gov/idg/api/v1/targets(16745)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/properties"},"_links":{"count":1211,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/links"},"_synonyms":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(16745)/publications"},"_namespace":null},{"id":16746,"version":3,"created":1554993989000,"modified":1555043473000,"deprecated":false,"name":"snRNA-activating protein complex subunit 1","accession":"Q16533","gene":"SNAPC1","description":"Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. 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Recruits TBP and BRF2 to the U6 snRNA TATA box.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7306669516590141,"antibodyCount":128,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.92074,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":30.470850442744506,"pubTatorScore":0.8327139407113583,"self":"https://pharos.nih.gov/idg/api/v1/targets(16746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/properties"},"_links":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(16746)/publications"},"_namespace":null},{"id":16747,"version":2,"created":1554993996000,"modified":1554993999000,"deprecated":false,"name":"Secreted frizzled-related protein 5","accession":"Q5T4F7","gene":"SFRP5","description":"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. 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Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5568699035071527,"antibodyCount":87,"monoclonalCount":27,"pubmedCount":null,"jensenScore":34.193826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.49323183847568,"pubTatorScore":0.6976929531205318,"self":"https://pharos.nih.gov/idg/api/v1/targets(16782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16782)/publications"},"_namespace":null},{"id":16783,"version":2,"created":1554994637000,"modified":1554994641000,"deprecated":false,"name":"Prokineticin receptor 1","accession":"Q8TCW9","gene":"PROKR1","description":"Receptor for prokineticin 1. 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The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6815071764925813,"antibodyCount":281,"monoclonalCount":119,"pubmedCount":null,"jensenScore":49.977391,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.83896418516543,"pubTatorScore":1.4617503565608407,"self":"https://pharos.nih.gov/idg/api/v1/targets(16831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/properties"},"_links":{"count":1075,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(16831)/publications"},"_namespace":null},{"id":16832,"version":3,"created":1554995031000,"modified":1555043544000,"deprecated":false,"name":"Cyclin-Q","accession":"Q8N1B3","gene":"CCNQ","description":"Activating cyclin for the cyclin-associated kinase CDK10.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8902588677511418,"antibodyCount":14,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.30982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":0.5622928644564748,"self":"https://pharos.nih.gov/idg/api/v1/targets(16832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":173,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/properties"},"_links":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(16832)/publications"},"_namespace":null},{"id":16833,"version":2,"created":1554995032000,"modified":1554995035000,"deprecated":false,"name":"Calcium-binding protein 4","accession":"P57796","gene":"CABP4","description":"Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5790577244364854,"antibodyCount":144,"monoclonalCount":27,"pubmedCount":null,"jensenScore":38.725806,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.63639905446509,"pubTatorScore":1.1809792824690748,"self":"https://pharos.nih.gov/idg/api/v1/targets(16833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(16833)/publications"},"_namespace":null},{"id":16834,"version":2,"created":1554995036000,"modified":1554995039000,"deprecated":false,"name":"Signal peptide peptidase-like 3","accession":"Q8TCT6","gene":"SPPL3","description":"Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3676886107237498,"antibodyCount":88,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.896859,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.77548191664153,"pubTatorScore":1.083169748190052,"self":"https://pharos.nih.gov/idg/api/v1/targets(16834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16834)/publications"},"_namespace":null},{"id":16835,"version":2,"created":1554995040000,"modified":1554995044000,"deprecated":false,"name":"Dynein heavy chain 3, axonemal","accession":"Q8TD57","gene":"DNAH3","description":"Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.1583265617933391,"antibodyCount":12,"monoclonalCount":1,"pubmedCount":null,"jensenScore":13.845539,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.988363269856244,"pubTatorScore":0.48952312351560606,"self":"https://pharos.nih.gov/idg/api/v1/targets(16835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(16835)/publications"},"_namespace":null},{"id":16836,"version":3,"created":1554995045000,"modified":1555043545000,"deprecated":false,"name":"Vacuolar protein sorting-associated protein 52 homolog","accession":"Q8N1B4","gene":"VPS52","description":"Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6756136146207612,"antibodyCount":92,"monoclonalCount":2,"pubmedCount":null,"jensenScore":40.503807,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.43349263455112,"pubTatorScore":2.8147468784989904,"self":"https://pharos.nih.gov/idg/api/v1/targets(16836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/properties"},"_links":{"count":1024,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(16836)/publications"},"_namespace":null},{"id":16837,"version":3,"created":1554995049000,"modified":1555043548000,"deprecated":false,"name":"Signal peptide peptidase-like 2B","accession":"Q8TCT7","gene":"SPPL2B","description":"Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":77,"knowledgeAvailability":29.50927986870489,"pubTatorScore":1.2355584677384677,"self":"https://pharos.nih.gov/idg/api/v1/targets(16837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":359,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/properties"},"_links":{"count":804,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(16837)/publications"},"_namespace":null},{"id":16838,"version":2,"created":1554995053000,"modified":1554995058000,"deprecated":false,"name":"Signal peptide peptidase-like 2A","accession":"Q8TCT8","gene":"SPPL2A","description":"Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3403539637945312,"antibodyCount":84,"monoclonalCount":6,"pubmedCount":null,"jensenScore":24.035552,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.2445647565235,"pubTatorScore":1.1900091357734188,"self":"https://pharos.nih.gov/idg/api/v1/targets(16838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(16838)/publications"},"_namespace":null},{"id":16839,"version":2,"created":1554995059000,"modified":1554995064000,"deprecated":false,"name":"Minor histocompatibility antigen H13","accession":"Q8TCT9","gene":"HM13","description":"Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4806052046189824,"antibodyCount":113,"monoclonalCount":2,"pubmedCount":null,"jensenScore":278.808411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.97606337230304,"pubTatorScore":2.6081780596289543,"self":"https://pharos.nih.gov/idg/api/v1/targets(16839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/properties"},"_links":{"count":1211,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(16839)/publications"},"_namespace":null},{"id":16840,"version":2,"created":1554995065000,"modified":1554995068000,"deprecated":false,"name":"Zinc finger protein 630","accession":"Q2M218","gene":"ZNF630","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.7,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.62290981755242,"pubTatorScore":0.09691001300805642,"self":"https://pharos.nih.gov/idg/api/v1/targets(16840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(16840)/publications"},"_namespace":null},{"id":16841,"version":3,"created":1554995068000,"modified":1555043549000,"deprecated":false,"name":"Ceramide kinase-like protein","accession":"Q49MI3","gene":"CERKL","description":"Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1428014920195833,"antibodyCount":99,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.985479,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":29.280803420784995,"pubTatorScore":1.4322118686338456,"self":"https://pharos.nih.gov/idg/api/v1/targets(16841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(16841)/publications"},"_namespace":null},{"id":16842,"version":3,"created":1554995073000,"modified":1555043550000,"deprecated":false,"name":"Kinesin-like protein KIF7","accession":"Q2M1P5","gene":"KIF7","description":"Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5055988190051002,"antibodyCount":64,"monoclonalCount":11,"pubmedCount":null,"jensenScore":33.4443,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.224113115074367,"pubTatorScore":1.4283048971954762,"self":"https://pharos.nih.gov/idg/api/v1/targets(16842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(16842)/publications"},"_namespace":null},{"id":16843,"version":2,"created":1554995078000,"modified":1554995085000,"deprecated":false,"name":"Beta-sarcoglycan","accession":"Q16585","gene":"SGCB","description":"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular 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of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular 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74","accession":"Q16587","gene":"ZNF74","description":"May play a role in RNA metabolism.","idgFamily":"Transcription 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hydration of carbon 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Together with MYO5B regulates transcytosis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7959473382062718,"antibodyCount":212,"monoclonalCount":66,"pubmedCount":null,"jensenScore":62.735189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.919181715008527,"pubTatorScore":1.7041898333016292,"self":"https://pharos.nih.gov/idg/api/v1/targets(16893)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16893)/publications"},"_namespace":null},{"id":16894,"version":2,"created":1554995500000,"modified":1554995505000,"deprecated":false,"name":"Polypeptide N-acetylgalactosaminyltransferase 14","accession":"Q96FL9","gene":"GALNT14","description":"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. 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Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.104907997147778,"antibodyCount":103,"monoclonalCount":1,"pubmedCount":null,"jensenScore":126.585921,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.317737583996742,"pubTatorScore":1.8457777618740048,"self":"https://pharos.nih.gov/idg/api/v1/targets(16895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16895)/publications"},"_namespace":null},{"id":16896,"version":2,"created":1554995552000,"modified":1554995552000,"deprecated":false,"name":"Putative uncharacterized protein C12orf77","accession":"C9JDV5","gene":"C12orf77","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16896)/publications"},"_namespace":null},{"id":16897,"version":2,"created":1554995552000,"modified":1554995553000,"deprecated":false,"name":"Putative uncharacterized protein ZNF295-AS1","accession":"Q8N0V1","gene":"ZNF295-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.579469636587316,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/links"},"_synonyms":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16897)/publications"},"_namespace":null},{"id":16898,"version":3,"created":1554995553000,"modified":1555043598000,"deprecated":false,"name":"Leucine-rich repeat LGI family member 2","accession":"Q8N0V4","gene":"LGI2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8889012516115797,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.8404,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.464215419317455,"pubTatorScore":0.794720328592532,"self":"https://pharos.nih.gov/idg/api/v1/targets(16898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/properties"},"_links":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(16898)/publications"},"_namespace":null},{"id":16899,"version":3,"created":1554995557000,"modified":1555043599000,"deprecated":false,"name":"Protein pitchfork","accession":"Q8TCI5","gene":"PIFO","description":"During primary cilia disassembly, involved in cilia disassembly. 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May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.532784638646088,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.609052,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":20.588877396295292,"pubTatorScore":1.8702087566935173,"self":"https://pharos.nih.gov/idg/api/v1/targets(16899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/properties"},"_links":{"count":847,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16899)/publications"},"_namespace":null},{"id":16900,"version":3,"created":1554995561000,"modified":1555043600000,"deprecated":false,"name":"Putative ribosome-binding factor A, mitochondrial","accession":"Q8N0V3","gene":"RBFA","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9526310391801692,"antibodyCount":54,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.440044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":27.943710508842347,"pubTatorScore":0.3222192947339193,"self":"https://pharos.nih.gov/idg/api/v1/targets(16900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/properties"},"_links":{"count":909,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(16900)/publications"},"_namespace":null},{"id":16901,"version":3,"created":1554995564000,"modified":1555043601000,"deprecated":false,"name":"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase","accession":"Q8N0V5","gene":"GCNT2","description":"Isoform C: Determines the expression of the blood group I antigen in erythrocytes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8777821551151042,"antibodyCount":179,"monoclonalCount":2,"pubmedCount":null,"jensenScore":71.628891,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":45.48207719946515,"pubTatorScore":1.555382378662851,"self":"https://pharos.nih.gov/idg/api/v1/targets(16901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(16901)/publications"},"_namespace":null},{"id":16902,"version":2,"created":1554995570000,"modified":1554995574000,"deprecated":false,"name":"Calmodulin-regulated spectrin-associated protein 2","accession":"Q08AD1","gene":"CAMSAP2","description":"Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8145805301248895,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.80083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.747460928341546,"pubTatorScore":0.865301406361885,"self":"https://pharos.nih.gov/idg/api/v1/targets(16902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/properties"},"_links":{"count":1050,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(16902)/publications"},"_namespace":null},{"id":16903,"version":2,"created":1554995576000,"modified":1554995580000,"deprecated":false,"name":"Keratin, type I cytoskeletal 16","accession":"P08779","gene":"KRT16","description":"Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2053760397403708,"antibodyCount":389,"monoclonalCount":141,"pubmedCount":null,"jensenScore":149.329912,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.45291691206872,"pubTatorScore":2.3138823719225257,"self":"https://pharos.nih.gov/idg/api/v1/targets(16903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16903)/publications"},"_namespace":null},{"id":16904,"version":2,"created":1554995580000,"modified":1554995600000,"deprecated":false,"name":"Voltage-dependent T-type calcium channel subunit alpha-1I","accession":"Q9P0X4","gene":"CACNA1I","description":"Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the \"low-voltage activated (LVA)\" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.9544607103633358,"antibodyCount":79,"monoclonalCount":36,"pubmedCount":null,"jensenScore":85.601066,"patentCount":1366,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.43877811774742,"pubTatorScore":1.411332976974196,"self":"https://pharos.nih.gov/idg/api/v1/targets(16904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(16904)/publications"},"_namespace":null},{"id":16905,"version":2,"created":1554995601000,"modified":1554995602000,"deprecated":false,"name":"Putative serine protease 46","accession":"E5RG02","gene":"PRSS46P","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":1.1760912590556813,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.05,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/properties"},"_links":{"count":580,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(16905)/publications"},"_namespace":null},{"id":16906,"version":2,"created":1554995603000,"modified":1554995608000,"deprecated":false,"name":"Nuclear pore complex protein Nup107","accession":"P57740","gene":"NUP107","description":"Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4902109712752694,"antibodyCount":165,"monoclonalCount":4,"pubmedCount":null,"jensenScore":31.493171,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.651794434836816,"pubTatorScore":1.4633799947757158,"self":"https://pharos.nih.gov/idg/api/v1/targets(16906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(16906)/publications"},"_namespace":null},{"id":16907,"version":2,"created":1554995609000,"modified":1554995613000,"deprecated":false,"name":"Lamin-B2","accession":"Q03252","gene":"LMNB2","description":"Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.006613594976143,"antibodyCount":208,"monoclonalCount":82,"pubmedCount":null,"jensenScore":99.051594,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.54332046258415,"pubTatorScore":1.8722998867993867,"self":"https://pharos.nih.gov/idg/api/v1/targets(16907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/properties"},"_links":{"count":1063,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(16907)/publications"},"_namespace":null},{"id":16908,"version":3,"created":1554995614000,"modified":1555043603000,"deprecated":false,"name":"Troponin I, cardiac muscle","accession":"P19429","gene":"TNNI3","description":"Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.5528109487312003,"antibodyCount":1706,"monoclonalCount":1087,"pubmedCount":null,"jensenScore":3485.562815,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.85839824450499,"pubTatorScore":3.2149668606902027,"self":"https://pharos.nih.gov/idg/api/v1/targets(16908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":606,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/synonyms"},"_publications":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(16908)/publications"},"_namespace":null},{"id":16909,"version":2,"created":1554995621000,"modified":1554995621000,"deprecated":false,"name":"Putative uncharacterized protein FLJ23865","accession":"Q8TCH9","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/links"},"_synonyms":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(16909)/publications"},"_namespace":null},{"id":16910,"version":3,"created":1554995621000,"modified":1555043605000,"deprecated":false,"name":"Cell cycle and apoptosis regulator protein 2","accession":"Q8N163","gene":"CCAR2","description":"Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro 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Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0300811193091315,"antibodyCount":268,"monoclonalCount":23,"pubmedCount":null,"jensenScore":1099.34826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.94945082090208,"pubTatorScore":2.985680286120373,"self":"https://pharos.nih.gov/idg/api/v1/targets(16980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":498,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/synonyms"},"_publications":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(16980)/publications"},"_namespace":null},{"id":16981,"version":3,"created":1554996196000,"modified":1555043672000,"deprecated":false,"name":"Transmembrane protein 9","accession":"Q9P0T7","gene":"TMEM9","description":"May be involved in intracellular transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8650193305572615,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.924836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":83,"knowledgeAvailability":30.2230541448633,"pubTatorScore":0.10914437291517246,"self":"https://pharos.nih.gov/idg/api/v1/targets(16981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(16981)/publications"},"_namespace":null},{"id":16982,"version":3,"created":1554996200000,"modified":1555043673000,"deprecated":false,"name":"Early growth response protein 1","accession":"P18146","gene":"EGR1","description":"Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.2981730696028606,"antibodyCount":394,"monoclonalCount":175,"pubmedCount":null,"jensenScore":2034.616214,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":50.560283904104814,"pubTatorScore":3.013613798203982,"self":"https://pharos.nih.gov/idg/api/v1/targets(16982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/properties"},"_links":{"count":1410,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/synonyms"},"_publications":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(16982)/publications"},"_namespace":null},{"id":16983,"version":2,"created":1554996210000,"modified":1554996211000,"deprecated":false,"name":"Olfactory receptor 4N4","accession":"Q8N0Y3","gene":"OR4N4","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":0.037788560527487726,"antibodyCount":70,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.875,"patentCount":249,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.32701925613628,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(16983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/properties"},"_links":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(16983)/publications"},"_namespace":null},{"id":16984,"version":2,"created":1554996211000,"modified":1554996217000,"deprecated":false,"name":"PH domain leucine-rich repeat-containing protein phosphatase 1","accession":"O60346","gene":"PHLPP1","description":"Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.9889737167453667,"antibodyCount":128,"monoclonalCount":0,"pubmedCount":null,"jensenScore":103.862427,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.2150555210458,"pubTatorScore":2.0028891064955046,"self":"https://pharos.nih.gov/idg/api/v1/targets(16984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(16984)/publications"},"_namespace":null},{"id":16985,"version":2,"created":1554996218000,"modified":1554996222000,"deprecated":false,"name":"TBC1 domain family member 12","accession":"O60347","gene":"TBC1D12","description":"May act as a GTPase-activating protein for Rab family protein(s).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06694678818296496,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.365801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.940603044514877,"pubTatorScore":-1.255269030761348,"self":"https://pharos.nih.gov/idg/api/v1/targets(16985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/properties"},"_links":{"count":851,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(16985)/publications"},"_namespace":null},{"id":16986,"version":3,"created":1554996223000,"modified":1555043676000,"deprecated":false,"name":"Zinc finger protein 444","accession":"Q8N0Y2","gene":"ZNF444","description":"Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.30068518116440457,"antibodyCount":65,"monoclonalCount":8,"pubmedCount":null,"jensenScore":1.389325,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":31.183183524783857,"pubTatorScore":0.5702391777754187,"self":"https://pharos.nih.gov/idg/api/v1/targets(16986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(16986)/publications"},"_namespace":null},{"id":16987,"version":3,"created":1554996227000,"modified":1555043677000,"deprecated":false,"name":"Endothelin-converting enzyme 2","accession":"O60344","gene":"ECE2","description":"Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid-beta peptide accumulation in brain. May also have methyltransferase activity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.4416546130788872,"antibodyCount":84,"monoclonalCount":3,"pubmedCount":null,"jensenScore":26.807623,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":40.567646623972855,"pubTatorScore":1.4507108319944746,"self":"https://pharos.nih.gov/idg/api/v1/targets(16987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/properties"},"_links":{"count":861,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(16987)/publications"},"_namespace":null},{"id":16988,"version":2,"created":1554996233000,"modified":1554996234000,"deprecated":false,"name":"Olfactory receptor 8I2","accession":"Q8N0Y5","gene":"OR8I2","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":null,"antibodyCount":40,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":235,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.775161858395315,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(16988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/properties"},"_links":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16988)/publications"},"_namespace":null},{"id":16989,"version":2,"created":1554996234000,"modified":1554996236000,"deprecated":false,"name":"Probable phosphoglycerate mutase 4","accession":"Q8N0Y7","gene":"PGAM4","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1984552529405341,"antibodyCount":75,"monoclonalCount":12,"pubmedCount":null,"jensenScore":14.467355,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.630305304184365,"pubTatorScore":1.0107238230215778,"self":"https://pharos.nih.gov/idg/api/v1/targets(16989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(16989)/publications"},"_namespace":null},{"id":16990,"version":2,"created":1554996237000,"modified":1554996240000,"deprecated":false,"name":"Protein PAT1 homolog 2","accession":"C9JE40","gene":"PATL2","description":"RNA-binding protein that acts as a translational repressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8218097515346166,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.889851,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.50736207400636,"pubTatorScore":-0.1549019599857432,"self":"https://pharos.nih.gov/idg/api/v1/targets(16990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(16990)/publications"},"_namespace":null},{"id":16991,"version":2,"created":1554996240000,"modified":1554996245000,"deprecated":false,"name":"TBC1 domain family member 4","accession":"O60343","gene":"TBC1D4","description":"May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.067506448992282,"antibodyCount":300,"monoclonalCount":25,"pubmedCount":null,"jensenScore":113.51027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.97578045313792,"pubTatorScore":1.9185689474209213,"self":"https://pharos.nih.gov/idg/api/v1/targets(16991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":468,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/properties"},"_links":{"count":1134,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(16991)/publications"},"_namespace":null},{"id":16992,"version":3,"created":1554996246000,"modified":1555043678000,"deprecated":false,"name":"Gastrin-releasing peptide","accession":"P07492","gene":"GRP","description":"Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.4104189796601356,"antibodyCount":199,"monoclonalCount":9,"pubmedCount":null,"jensenScore":2788.91743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":26.23619185548866,"pubTatorScore":3.1818791446356047,"self":"https://pharos.nih.gov/idg/api/v1/targets(16992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/properties"},"_links":{"count":661,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(16992)/publications"},"_namespace":null},{"id":16993,"version":4,"created":1554996253000,"modified":1555043679000,"deprecated":false,"name":"Lysine-specific histone demethylase 1A","accession":"O60341","gene":"KDM1A","description":"Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-2.6869177485408855,"antibodyCount":473,"monoclonalCount":92,"pubmedCount":null,"jensenScore":516.27076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.8715087069576,"pubTatorScore":2.512773240098752,"self":"https://pharos.nih.gov/idg/api/v1/targets(16993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":681,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/properties"},"_links":{"count":1498,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/links"},"_synonyms":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(16993)/publications"},"_namespace":null},{"id":16994,"version":3,"created":1554996332000,"modified":1555043682000,"deprecated":false,"name":"Fibroblast growth factor 7","accession":"P21781","gene":"FGF7","description":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. 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