{"id":327298,"version":1,"created":1584652411458,"modified":1584652411463,"deprecated":false,"etag":"aa1bb970d3004b65","uri":"https://pharos.nih.gov/idg/api/v1/targets?top=1000&skip=10000","path":"/idg/api/v1/targets","method":"GET","sha1":"97018d676813cb41bf1f03d84edfcc589327cc0f","total":20244,"count":1000,"skip":10000,"top":1000,"status":null,"query":"skip=10000&top=1000","filter":null,"_namespace":null,"content":[{"id":10001,"version":2,"created":1554927912000,"modified":1554927915000,"deprecated":false,"name":"UPF0472 protein C16orf72","accession":"Q14CZ0","gene":"C16orf72","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.48811663945542005,"antibodyCount":65,"monoclonalCount":38,"pubmedCount":null,"jensenScore":0.321429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.3467874862246563,"self":"https://pharos.nih.gov/idg/api/v1/targets(10001)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(10001)/properties"},"_links":{"count":796,"href":"https://pharos.nih.gov/idg/api/v1/targets(10001)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10001)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10001)/publications"},"_namespace":null},{"id":10002,"version":2,"created":1554927915000,"modified":1554927918000,"deprecated":false,"name":"PDZ domain-containing protein 4","accession":"Q76G19","gene":"PDZD4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9323950706984094,"antibodyCount":94,"monoclonalCount":0,"pubmedCount":null,"jensenScore":82.12012,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.612015004126807,"pubTatorScore":1.5218382897089135,"self":"https://pharos.nih.gov/idg/api/v1/targets(10002)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(10002)/properties"},"_links":{"count":853,"href":"https://pharos.nih.gov/idg/api/v1/targets(10002)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10002)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10002)/publications"},"_namespace":null},{"id":10003,"version":2,"created":1554927919000,"modified":1554927925000,"deprecated":false,"name":"Calmodulin-2","accession":"P0DP24","gene":"CALM3","description":"Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.5983410275048477,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5859.505004,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.785312311942851,"self":"https://pharos.nih.gov/idg/api/v1/targets(10003)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":691,"href":"https://pharos.nih.gov/idg/api/v1/targets(10003)/properties"},"_links":{"count":1763,"href":"https://pharos.nih.gov/idg/api/v1/targets(10003)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10003)/synonyms"},"_publications":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10003)/publications"},"_namespace":null},{"id":10004,"version":2,"created":1554927927000,"modified":1554927931000,"deprecated":false,"name":"Calmodulin-3","accession":"P0DP25","gene":"CALM3","description":"Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-3.5914039235372175,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5859.505004,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.785312311942851,"self":"https://pharos.nih.gov/idg/api/v1/targets(10004)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":605,"href":"https://pharos.nih.gov/idg/api/v1/targets(10004)/properties"},"_links":{"count":1453,"href":"https://pharos.nih.gov/idg/api/v1/targets(10004)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10004)/synonyms"},"_publications":{"count":153,"href":"https://pharos.nih.gov/idg/api/v1/targets(10004)/publications"},"_namespace":null},{"id":10005,"version":2,"created":1554927932000,"modified":1554927936000,"deprecated":false,"name":"Lysosomal acid phosphatase","accession":"P11117","gene":"ACP2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.383167534598974,"antibodyCount":83,"monoclonalCount":17,"pubmedCount":null,"jensenScore":237.012053,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.25762047975159,"pubTatorScore":1.579159707547431,"self":"https://pharos.nih.gov/idg/api/v1/targets(10005)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(10005)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(10005)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10005)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10005)/publications"},"_namespace":null},{"id":10006,"version":2,"created":1554927937000,"modified":1554927940000,"deprecated":false,"name":"Hepatocyte cell adhesion molecule","accession":"Q14CZ8","gene":"HEPACAM","description":"Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6118744544538393,"antibodyCount":135,"monoclonalCount":4,"pubmedCount":null,"jensenScore":45.563984,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.198830911453136,"pubTatorScore":1.602525045350896,"self":"https://pharos.nih.gov/idg/api/v1/targets(10006)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10006)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(10006)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10006)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(10006)/publications"},"_namespace":null},{"id":10007,"version":2,"created":1554927941000,"modified":1554927943000,"deprecated":false,"name":"FAST kinase domain-containing protein 3, mitochondrial","accession":"Q14CZ7","gene":"FASTKD3","description":"Required for normal mitochondrial respiration.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.39064077101627437,"antibodyCount":127,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.899159,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.38749580579394,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10007)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(10007)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(10007)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10007)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10007)/publications"},"_namespace":null},{"id":10008,"version":2,"created":1554927944000,"modified":1554927946000,"deprecated":false,"name":"Golgi pH regulator A","accession":"B7ZAQ6","gene":"GPR89A","description":"Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.6281455577395804,"antibodyCount":97,"monoclonalCount":16,"pubmedCount":null,"jensenScore":7.024011,"patentCount":115,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.380593418176666,"pubTatorScore":0.9661417327390326,"self":"https://pharos.nih.gov/idg/api/v1/targets(10008)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(10008)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(10008)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10008)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10008)/publications"},"_namespace":null},{"id":10009,"version":2,"created":1554927947000,"modified":1554927949000,"deprecated":false,"name":"Gap junction gamma-3 protein","accession":"Q8NFK1","gene":"GJC3","description":"One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2674790266123364,"antibodyCount":140,"monoclonalCount":0,"pubmedCount":null,"jensenScore":19.686301,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.564895901295014,"pubTatorScore":1.306851113350959,"self":"https://pharos.nih.gov/idg/api/v1/targets(10009)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10009)/properties"},"_links":{"count":769,"href":"https://pharos.nih.gov/idg/api/v1/targets(10009)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10009)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10009)/publications"},"_namespace":null},{"id":10010,"version":3,"created":1554927950000,"modified":1555039118000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 4D","accession":"P49703","gene":"ARL4D","description":"Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6268920566515793,"antibodyCount":92,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.401974,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":30.83336353553287,"pubTatorScore":0.8336478242519474,"self":"https://pharos.nih.gov/idg/api/v1/targets(10010)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(10010)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(10010)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10010)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10010)/publications"},"_namespace":null},{"id":10011,"version":2,"created":1554927953000,"modified":1554927957000,"deprecated":false,"name":"Fanconi anemia group A protein","accession":"O15360","gene":"FANCA","description":"DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.378491371178401,"antibodyCount":314,"monoclonalCount":35,"pubmedCount":null,"jensenScore":237.443606,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.61665965861947,"pubTatorScore":2.4195922669822747,"self":"https://pharos.nih.gov/idg/api/v1/targets(10011)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":399,"href":"https://pharos.nih.gov/idg/api/v1/targets(10011)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(10011)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(10011)/synonyms"},"_publications":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10011)/publications"},"_namespace":null},{"id":10012,"version":3,"created":1554927959000,"modified":1555039119000,"deprecated":false,"name":"Sesquipedalian-2","accession":"Q6ICB4","gene":"FAM109B","description":"Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.9030899869919435,"antibodyCount":21,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":20.52250242682789,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(10012)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(10012)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(10012)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10012)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10012)/publications"},"_namespace":null},{"id":10013,"version":3,"created":1554927961000,"modified":1555039120000,"deprecated":false,"name":"Angiomotin-like protein 1","accession":"Q8IY63","gene":"AMOTL1","description":"Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1981987460637917,"antibodyCount":90,"monoclonalCount":6,"pubmedCount":null,"jensenScore":15.221062,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.43240769192964,"pubTatorScore":1.0942478445879915,"self":"https://pharos.nih.gov/idg/api/v1/targets(10013)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(10013)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(10013)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10013)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10013)/publications"},"_namespace":null},{"id":10014,"version":2,"created":1554927965000,"modified":1554927967000,"deprecated":false,"name":"FERM domain-containing protein 7","accession":"Q6ZUT3","gene":"FRMD7","description":"Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8843232676260018,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":81.281587,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.739391971261263,"pubTatorScore":1.8736111911865077,"self":"https://pharos.nih.gov/idg/api/v1/targets(10014)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(10014)/properties"},"_links":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(10014)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10014)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(10014)/publications"},"_namespace":null},{"id":10015,"version":2,"created":1554927968000,"modified":1554927970000,"deprecated":false,"name":"WW domain-binding protein 2","accession":"Q969T9","gene":"WBP2","description":"Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0464718165526632,"antibodyCount":97,"monoclonalCount":7,"pubmedCount":null,"jensenScore":12.770006,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.3328479127323,"pubTatorScore":0.8689754103679539,"self":"https://pharos.nih.gov/idg/api/v1/targets(10015)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(10015)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(10015)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10015)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10015)/publications"},"_namespace":null},{"id":10016,"version":3,"created":1554927971000,"modified":1555039123000,"deprecated":false,"name":"Uncharacterized protein NKAPD1","accession":"Q6ZUT1","gene":"NKAPD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3521825181113625,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":66,"knowledgeAvailability":0.0,"pubTatorScore":-0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10016)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(10016)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(10016)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10016)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10016)/publications"},"_namespace":null},{"id":10017,"version":2,"created":1554927974000,"modified":1554927976000,"deprecated":false,"name":"DNA-binding protein RFX8","accession":"Q6ZV50","gene":"RFX8","description":"May be a transcription factor.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.526967219233804,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10017)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(10017)/properties"},"_links":{"count":676,"href":"https://pharos.nih.gov/idg/api/v1/targets(10017)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10017)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10017)/publications"},"_namespace":null},{"id":10018,"version":3,"created":1554927977000,"modified":1555039124000,"deprecated":false,"name":"Solute carrier family 35 member F2","accession":"Q8IXU6","gene":"SLC35F2","description":"Putative solute transporter.","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.7543908110935239,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.070111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":31.41163485619347,"pubTatorScore":0.7340501649226003,"self":"https://pharos.nih.gov/idg/api/v1/targets(10018)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(10018)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(10018)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10018)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10018)/publications"},"_namespace":null},{"id":10019,"version":2,"created":1554927980000,"modified":1554927982000,"deprecated":false,"name":"Ribonucleoprotein PTB-binding 1","accession":"Q8IY67","gene":"RAVER1","description":"Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9420080693083567,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.201234,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.791771959966866,"pubTatorScore":0.946124602828674,"self":"https://pharos.nih.gov/idg/api/v1/targets(10019)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(10019)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(10019)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10019)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10019)/publications"},"_namespace":null},{"id":10020,"version":3,"created":1554927983000,"modified":1555039125000,"deprecated":false,"name":"SPRY domain-containing protein 7","accession":"Q5W111","gene":"SPRYD7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.32418443337109304,"antibodyCount":38,"monoclonalCount":12,"pubmedCount":null,"jensenScore":2.156226,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":28.720489241601054,"pubTatorScore":0.6925111582867318,"self":"https://pharos.nih.gov/idg/api/v1/targets(10020)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(10020)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(10020)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10020)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10020)/publications"},"_namespace":null},{"id":10021,"version":2,"created":1554927987000,"modified":1554927989000,"deprecated":false,"name":"Coiled-coil domain-containing protein 149","accession":"Q6ZUS6","gene":"CCDC149","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5952205667976569,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.155556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.553718485914477,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10021)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(10021)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(10021)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10021)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10021)/publications"},"_namespace":null},{"id":10022,"version":2,"created":1554927990000,"modified":1554927996000,"deprecated":false,"name":"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2","accession":"O15357","gene":"INPPL1","description":"Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.050557783561384,"antibodyCount":215,"monoclonalCount":33,"pubmedCount":null,"jensenScore":144.205797,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.1769680602593,"pubTatorScore":2.101572348658232,"self":"https://pharos.nih.gov/idg/api/v1/targets(10022)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(10022)/properties"},"_links":{"count":1182,"href":"https://pharos.nih.gov/idg/api/v1/targets(10022)/links"},"_synonyms":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(10022)/synonyms"},"_publications":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10022)/publications"},"_namespace":null},{"id":10023,"version":3,"created":1554927997000,"modified":1555039126000,"deprecated":false,"name":"Coiled-coil domain-containing protein 121","accession":"Q6ZUS5","gene":"CCDC121","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4296966044017729,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.347985,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":23.482176134042025,"pubTatorScore":-1.462394957848223,"self":"https://pharos.nih.gov/idg/api/v1/targets(10023)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(10023)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(10023)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10023)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10023)/publications"},"_namespace":null},{"id":10024,"version":2,"created":1554928001000,"modified":1554928003000,"deprecated":false,"name":"Protein phosphatase 1G","accession":"O15355","gene":"PPM1G","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5128430931341061,"antibodyCount":298,"monoclonalCount":74,"pubmedCount":null,"jensenScore":27.966444,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.30012964523843,"pubTatorScore":1.2036673477297835,"self":"https://pharos.nih.gov/idg/api/v1/targets(10024)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(10024)/properties"},"_links":{"count":1074,"href":"https://pharos.nih.gov/idg/api/v1/targets(10024)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10024)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10024)/publications"},"_namespace":null},{"id":10025,"version":2,"created":1554928004000,"modified":1554928007000,"deprecated":false,"name":"7-methylguanosine phosphate-specific 5'-nucleotidase","accession":"Q969T7","gene":"NT5C3B","description":"Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4784977848720299,"antibodyCount":63,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.489611,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.4862821333992,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10025)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(10025)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(10025)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10025)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10025)/publications"},"_namespace":null},{"id":10026,"version":3,"created":1554928008000,"modified":1555039129000,"deprecated":false,"name":"Transmembrane protein 185A","accession":"Q8NFB2","gene":"TMEM185A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.4621840519995914,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":28.240926,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":44,"knowledgeAvailability":26.740657363254105,"pubTatorScore":1.5071595254198003,"self":"https://pharos.nih.gov/idg/api/v1/targets(10026)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(10026)/properties"},"_links":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(10026)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10026)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10026)/publications"},"_namespace":null},{"id":10027,"version":2,"created":1554928009000,"modified":1554928012000,"deprecated":false,"name":"Desumoylating isopeptidase 1","accession":"Q6ICB0","gene":"DESI1","description":"Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.1060533908555131,"antibodyCount":23,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.794872,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.394551363371715,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10027)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(10027)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(10027)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10027)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10027)/publications"},"_namespace":null},{"id":10028,"version":3,"created":1554928012000,"modified":1555039130000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 E3","accession":"Q969T4","gene":"UBE2E3","description":"Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1954823439666675,"antibodyCount":431,"monoclonalCount":263,"pubmedCount":null,"jensenScore":14.000532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":40.05574841277613,"pubTatorScore":1.04998511541653,"self":"https://pharos.nih.gov/idg/api/v1/targets(10028)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(10028)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(10028)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10028)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10028)/publications"},"_namespace":null},{"id":10029,"version":3,"created":1554928016000,"modified":1555039132000,"deprecated":false,"name":"Sorting nexin-21","accession":"Q969T3","gene":"SNX21","description":"Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.09177037418287294,"antibodyCount":73,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.154167,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":24.649632113927268,"pubTatorScore":0.4220736649133789,"self":"https://pharos.nih.gov/idg/api/v1/targets(10029)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(10029)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(10029)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10029)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10029)/publications"},"_namespace":null},{"id":10030,"version":3,"created":1554928020000,"modified":1555039134000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit D","accession":"O15371","gene":"EIF3D","description":"(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1484027891465807,"antibodyCount":153,"monoclonalCount":15,"pubmedCount":null,"jensenScore":15.858044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":37.957083483184086,"pubTatorScore":0.6969693859463912,"self":"https://pharos.nih.gov/idg/api/v1/targets(10030)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(10030)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10030)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10030)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10030)/publications"},"_namespace":null},{"id":10031,"version":2,"created":1554928025000,"modified":1554928025000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC00173","accession":"Q6ZV60","gene":"LINC00173","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.294835327037369,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10031)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10031)/properties"},"_links":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10031)/links"},"_synonyms":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10031)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10031)/publications"},"_namespace":null},{"id":10032,"version":3,"created":1554928025000,"modified":1555039135000,"deprecated":false,"name":"Eukaryotic translation initiation factor 3 subunit H","accession":"O15372","gene":"EIF3H","description":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4182350612500332,"antibodyCount":211,"monoclonalCount":51,"pubmedCount":null,"jensenScore":27.77138,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":38.07045708222343,"pubTatorScore":1.3016679831439468,"self":"https://pharos.nih.gov/idg/api/v1/targets(10032)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":449,"href":"https://pharos.nih.gov/idg/api/v1/targets(10032)/properties"},"_links":{"count":1107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10032)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10032)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10032)/publications"},"_namespace":null},{"id":10033,"version":2,"created":1554928030000,"modified":1554928032000,"deprecated":false,"name":"Putative thiamine transporter SLC35F3","accession":"Q8IY50","gene":"SLC35F3","description":"May be a thiamine transporter.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.35751135185770416,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.277778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.03622647292515,"pubTatorScore":0.49291550639237686,"self":"https://pharos.nih.gov/idg/api/v1/targets(10033)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(10033)/properties"},"_links":{"count":759,"href":"https://pharos.nih.gov/idg/api/v1/targets(10033)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10033)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10033)/publications"},"_namespace":null},{"id":10034,"version":3,"created":1554928033000,"modified":1555039137000,"deprecated":false,"name":"NADPH oxidase organizer 1","accession":"Q8NFA2","gene":"NOXO1","description":"Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3425899685280656,"antibodyCount":158,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.215475,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":24.400249328115326,"pubTatorScore":1.3822294165052729,"self":"https://pharos.nih.gov/idg/api/v1/targets(10034)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(10034)/properties"},"_links":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(10034)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10034)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10034)/publications"},"_namespace":null},{"id":10035,"version":3,"created":1554928035000,"modified":1555039138000,"deprecated":false,"name":"Tigger transposable element-derived protein 4","accession":"Q8IY51","gene":"TIGD4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":51,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.377602865227573,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10035)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(10035)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(10035)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10035)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10035)/publications"},"_namespace":null},{"id":10036,"version":2,"created":1554928038000,"modified":1554928040000,"deprecated":false,"name":"Transcription factor SOX-12","accession":"O15370","gene":"SOX12","description":"Binds to the sequence 5'-AACAAT-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.8622828727079731,"antibodyCount":174,"monoclonalCount":82,"pubmedCount":null,"jensenScore":6.998488,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.283586882098675,"pubTatorScore":0.741770441174764,"self":"https://pharos.nih.gov/idg/api/v1/targets(10036)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10036)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(10036)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10036)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10036)/publications"},"_namespace":null},{"id":10037,"version":2,"created":1554928041000,"modified":1554928044000,"deprecated":false,"name":"DNA damage-induced apoptosis suppressor protein","accession":"Q8IXT1","gene":"DDIAS","description":"May be an anti-apoptotic protein involved in DNA repair or cell survival.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0639674146216107,"antibodyCount":34,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.97434,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.83954065018455,"pubTatorScore":0.5965970956264602,"self":"https://pharos.nih.gov/idg/api/v1/targets(10037)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(10037)/properties"},"_links":{"count":849,"href":"https://pharos.nih.gov/idg/api/v1/targets(10037)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10037)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10037)/publications"},"_namespace":null},{"id":10038,"version":2,"created":1554928045000,"modified":1554928046000,"deprecated":false,"name":"Doublesex- and mab-3-related transcription factor C2","accession":"Q8IXT2","gene":"DMRTC2","description":"May be involved in sexual development.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.01848340533210112,"antibodyCount":107,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.57619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.280343887927565,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(10038)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(10038)/properties"},"_links":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(10038)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10038)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10038)/publications"},"_namespace":null},{"id":10039,"version":2,"created":1554928047000,"modified":1554928049000,"deprecated":false,"name":"Monocarboxylate transporter 6","accession":"O15375","gene":"SLC16A5","description":"Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).","idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.7409263437376444,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.968903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.58016690178526,"pubTatorScore":0.41218039174864657,"self":"https://pharos.nih.gov/idg/api/v1/targets(10039)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(10039)/properties"},"_links":{"count":804,"href":"https://pharos.nih.gov/idg/api/v1/targets(10039)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10039)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10039)/publications"},"_namespace":null},{"id":10040,"version":3,"created":1554928050000,"modified":1555039139000,"deprecated":false,"name":"Ribosome-releasing factor 2, mitochondrial","accession":"Q969S9","gene":"GFM2","description":"Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5424104046225138,"antibodyCount":86,"monoclonalCount":3,"pubmedCount":null,"jensenScore":36.419516,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.16352977086209,"pubTatorScore":1.022565814155245,"self":"https://pharos.nih.gov/idg/api/v1/targets(10040)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(10040)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(10040)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10040)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10040)/publications"},"_namespace":null},{"id":10041,"version":4,"created":1554928054000,"modified":1555039140000,"deprecated":false,"name":"Histone deacetylase 10","accession":"Q969S8","gene":"HDAC10","description":"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-1.6383705522677061,"antibodyCount":314,"monoclonalCount":93,"pubmedCount":null,"jensenScore":44.141593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":30.725860626174793,"pubTatorScore":1.49652722754381,"self":"https://pharos.nih.gov/idg/api/v1/targets(10041)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(10041)/properties"},"_links":{"count":1209,"href":"https://pharos.nih.gov/idg/api/v1/targets(10041)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10041)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10041)/publications"},"_namespace":null},{"id":10042,"version":2,"created":1554928065000,"modified":1554928066000,"deprecated":false,"name":"FOXL2 neighbor protein","accession":"Q6ZUU3","gene":"FOXL2NB","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.343948217962617,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10042)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10042)/properties"},"_links":{"count":618,"href":"https://pharos.nih.gov/idg/api/v1/targets(10042)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(10042)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10042)/publications"},"_namespace":null},{"id":10043,"version":2,"created":1554928067000,"modified":1554928069000,"deprecated":false,"name":"Retrotransposon Gag-like protein 6","accession":"Q6ICC9","gene":"RTL6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8372726889305979,"antibodyCount":86,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.066666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.7277735505740713,"self":"https://pharos.nih.gov/idg/api/v1/targets(10043)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(10043)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(10043)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10043)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10043)/publications"},"_namespace":null},{"id":10044,"version":3,"created":1554928070000,"modified":1555039142000,"deprecated":false,"name":"RNA-binding protein 12B","accession":"Q8IXT5","gene":"RBM12B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8556653368758896,"antibodyCount":20,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.121429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.23349911898102,"pubTatorScore":-1.230445447036316,"self":"https://pharos.nih.gov/idg/api/v1/targets(10044)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10044)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(10044)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10044)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10044)/publications"},"_namespace":null},{"id":10045,"version":2,"created":1554928073000,"modified":1554928077000,"deprecated":false,"name":"Monocarboxylate transporter 5","accession":"O15374","gene":"SLC16A4","description":"Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.3066021318146714,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.605682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.105158583046997,"pubTatorScore":1.6850302473873378,"self":"https://pharos.nih.gov/idg/api/v1/targets(10045)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(10045)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(10045)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10045)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10045)/publications"},"_namespace":null},{"id":10046,"version":3,"created":1554928078000,"modified":1555039145000,"deprecated":false,"name":"YY1-associated factor 2","accession":"Q8IY57","gene":"YAF2","description":"Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7582295320219687,"antibodyCount":100,"monoclonalCount":5,"pubmedCount":null,"jensenScore":6.095649,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":42,"knowledgeAvailability":36.16060544649534,"pubTatorScore":0.5411035058941378,"self":"https://pharos.nih.gov/idg/api/v1/targets(10046)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(10046)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(10046)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10046)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10046)/publications"},"_namespace":null},{"id":10047,"version":3,"created":1554928081000,"modified":1555039146000,"deprecated":false,"name":"Rab GTPase-activating protein 1-like, isoform 10","accession":"B7ZAP0","gene":"RABGAP1L","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4254879738989908,"antibodyCount":41,"monoclonalCount":10,"pubmedCount":null,"jensenScore":3.992227,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":0.0,"pubTatorScore":0.7588577913707819,"self":"https://pharos.nih.gov/idg/api/v1/targets(10047)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(10047)/properties"},"_links":{"count":326,"href":"https://pharos.nih.gov/idg/api/v1/targets(10047)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10047)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10047)/publications"},"_namespace":null},{"id":10048,"version":2,"created":1554928083000,"modified":1554928086000,"deprecated":false,"name":"Rho-related GTP-binding protein RhoG","accession":"P84095","gene":"RHOG","description":"Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0429662452767223,"antibodyCount":142,"monoclonalCount":12,"pubmedCount":null,"jensenScore":108.114605,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.967178713229615,"pubTatorScore":1.8723473610811963,"self":"https://pharos.nih.gov/idg/api/v1/targets(10048)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(10048)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(10048)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10048)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10048)/publications"},"_namespace":null},{"id":10049,"version":2,"created":1554928087000,"modified":1554928090000,"deprecated":false,"name":"60S ribosomal protein L19","accession":"P84098","gene":"RPL19","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5838438096033964,"antibodyCount":148,"monoclonalCount":26,"pubmedCount":null,"jensenScore":37.328656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.219375571966,"pubTatorScore":1.327688096800212,"self":"https://pharos.nih.gov/idg/api/v1/targets(10049)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(10049)/properties"},"_links":{"count":1087,"href":"https://pharos.nih.gov/idg/api/v1/targets(10049)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10049)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10049)/publications"},"_namespace":null},{"id":10050,"version":2,"created":1554928091000,"modified":1554928092000,"deprecated":false,"name":"Uncharacterized protein C19orf84","accession":"I3L1E1","gene":"C19orf84","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":31,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10050)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10050)/properties"},"_links":{"count":462,"href":"https://pharos.nih.gov/idg/api/v1/targets(10050)/links"},"_synonyms":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(10050)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10050)/publications"},"_namespace":null},{"id":10051,"version":2,"created":1554928093000,"modified":1554928095000,"deprecated":false,"name":"Uncharacterized protein C15orf52","accession":"Q6ZUT6","gene":"CCDC9B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.33881855619146894,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.458333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(10051)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(10051)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(10051)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10051)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10051)/publications"},"_namespace":null},{"id":10052,"version":3,"created":1554928096000,"modified":1555039147000,"deprecated":false,"name":"DNA oxidative demethylase ALKBH2","accession":"Q6NS38","gene":"ALKBH2","description":"Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8295068203876783,"antibodyCount":94,"monoclonalCount":6,"pubmedCount":null,"jensenScore":65.117344,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.580463845455636,"pubTatorScore":1.5421285908733902,"self":"https://pharos.nih.gov/idg/api/v1/targets(10052)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(10052)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(10052)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10052)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10052)/publications"},"_namespace":null},{"id":10053,"version":2,"created":1554928099000,"modified":1554928099000,"deprecated":false,"name":"Uncharacterized protein C22orf34","accession":"Q6ZV56","gene":"C22orf34","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10053)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10053)/properties"},"_links":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10053)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10053)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10053)/publications"},"_namespace":null},{"id":10054,"version":2,"created":1554928099000,"modified":1554928102000,"deprecated":false,"name":"Transmembrane protein 203","accession":"Q969S6","gene":"TMEM203","description":"Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3010299956639812,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.114693703002533,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10054)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(10054)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(10054)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(10054)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10054)/publications"},"_namespace":null},{"id":10055,"version":2,"created":1554928102000,"modified":1554928102000,"deprecated":false,"name":"Putative uncharacterized protein FLJ43343","accession":"Q6ZUT4","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10055)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10055)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10055)/links"},"_synonyms":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10055)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10055)/publications"},"_namespace":null},{"id":10056,"version":3,"created":1554928102000,"modified":1555039148000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 32","accession":"Q8NFA0","gene":"USP32","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1740363779525977,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.256545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.9876366601925,"pubTatorScore":0.9391030290677268,"self":"https://pharos.nih.gov/idg/api/v1/targets(10056)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(10056)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(10056)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10056)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10056)/publications"},"_namespace":null},{"id":10057,"version":2,"created":1554928106000,"modified":1554928109000,"deprecated":false,"name":"UDP-xylose and UDP-N-acetylglucosamine transporter","accession":"Q969S0","gene":"SLC35B4","description":"Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.2616767216389455,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.601759,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.68625733267536,"pubTatorScore":0.6730445114528965,"self":"https://pharos.nih.gov/idg/api/v1/targets(10057)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(10057)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(10057)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10057)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10057)/publications"},"_namespace":null},{"id":10058,"version":2,"created":1554928109000,"modified":1554928112000,"deprecated":false,"name":"Zinc finger protein 622","accession":"Q969S3","gene":"ZNF622","description":"May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3540169195787305,"antibodyCount":131,"monoclonalCount":62,"pubmedCount":null,"jensenScore":2.959073,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.65890363968284,"pubTatorScore":0.31875869313729016,"self":"https://pharos.nih.gov/idg/api/v1/targets(10058)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(10058)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(10058)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10058)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10058)/publications"},"_namespace":null},{"id":10059,"version":2,"created":1554928113000,"modified":1554928117000,"deprecated":false,"name":"DENN domain-containing protein 5B","accession":"Q6ZUT9","gene":"DENND5B","description":"Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.21635831614326,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10059)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(10059)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(10059)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10059)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10059)/publications"},"_namespace":null},{"id":10060,"version":2,"created":1554928118000,"modified":1554928121000,"deprecated":false,"name":"Endonuclease 8-like 2","accession":"Q969S2","gene":"NEIL2","description":"Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7492080788499473,"antibodyCount":107,"monoclonalCount":19,"pubmedCount":null,"jensenScore":49.005098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.69156476861462,"pubTatorScore":1.5850666174428223,"self":"https://pharos.nih.gov/idg/api/v1/targets(10060)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10060)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(10060)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10060)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(10060)/publications"},"_namespace":null},{"id":10061,"version":3,"created":1554928121000,"modified":1555039149000,"deprecated":false,"name":"Branched-chain-amino-acid aminotransferase, mitochondrial","accession":"O15382","gene":"BCAT2","description":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.826688707751209,"antibodyCount":170,"monoclonalCount":2,"pubmedCount":null,"jensenScore":64.716944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.89935292116609,"pubTatorScore":1.5340034129416429,"self":"https://pharos.nih.gov/idg/api/v1/targets(10061)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(10061)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10061)/links"},"_synonyms":{"count":219,"href":"https://pharos.nih.gov/idg/api/v1/targets(10061)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10061)/publications"},"_namespace":null},{"id":10062,"version":2,"created":1554928142000,"modified":1554928147000,"deprecated":false,"name":"Nuclear valosin-containing protein-like","accession":"O15381","gene":"NVL","description":"Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). May play a role in 60S ribosomal subunit biogenesis (PubMed:15469983, PubMed:16782053).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6791249602877034,"antibodyCount":153,"monoclonalCount":28,"pubmedCount":null,"jensenScore":49.592522,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.662396755391114,"pubTatorScore":0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(10062)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(10062)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(10062)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10062)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10062)/publications"},"_namespace":null},{"id":10063,"version":2,"created":1554928148000,"modified":1554928150000,"deprecated":false,"name":"Protein FAM217A","accession":"Q8IXS0","gene":"FAM217A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.263167191938694,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10063)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10063)/properties"},"_links":{"count":618,"href":"https://pharos.nih.gov/idg/api/v1/targets(10063)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10063)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10063)/publications"},"_namespace":null},{"id":10064,"version":3,"created":1554928150000,"modified":1555039150000,"deprecated":false,"name":"KICSTOR complex protein ITFG2","accession":"Q969R8","gene":"ITFG2","description":"As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.08715017475380135,"antibodyCount":148,"monoclonalCount":100,"pubmedCount":null,"jensenScore":1.188312,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.405586024655527,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10064)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(10064)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(10064)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10064)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10064)/publications"},"_namespace":null},{"id":10065,"version":3,"created":1554928154000,"modified":1555039151000,"deprecated":false,"name":"Uncharacterized protein C4orf19","accession":"Q8IY42","gene":"C4orf19","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10065)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(10065)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(10065)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10065)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10065)/publications"},"_namespace":null},{"id":10066,"version":3,"created":1554928157000,"modified":1555039152000,"deprecated":false,"name":"Coiled-coil domain-containing protein 65","accession":"Q8IXS2","gene":"CCDC65","description":"May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9934362417892684,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.389235,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":23.55635544284324,"pubTatorScore":0.5282737771670437,"self":"https://pharos.nih.gov/idg/api/v1/targets(10066)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(10066)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(10066)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10066)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10066)/publications"},"_namespace":null},{"id":10067,"version":3,"created":1554928160000,"modified":1555039153000,"deprecated":false,"name":"Protein AMN1 homolog","accession":"Q8IY45","gene":"AMN1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8076853361229357,"antibodyCount":115,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.831636,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.939878213778506,"pubTatorScore":0.6110147985282766,"self":"https://pharos.nih.gov/idg/api/v1/targets(10067)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10067)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(10067)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10067)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10067)/publications"},"_namespace":null},{"id":10068,"version":3,"created":1554928163000,"modified":1555039154000,"deprecated":false,"name":"Paralemmin-2","accession":"Q8IXS6","gene":"PALM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.103872656778358,"antibodyCount":44,"monoclonalCount":24,"pubmedCount":null,"jensenScore":4.719691,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":27.715252220348358,"pubTatorScore":0.6730446036547716,"self":"https://pharos.nih.gov/idg/api/v1/targets(10068)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(10068)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(10068)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10068)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10068)/publications"},"_namespace":null},{"id":10069,"version":2,"created":1554928167000,"modified":1554928170000,"deprecated":false,"name":"Kelch repeat and BTB domain-containing protein 2","accession":"Q8IY47","gene":"KBTBD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.015905040556911196,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.66624,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.79123255848019,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(10069)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(10069)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(10069)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10069)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10069)/publications"},"_namespace":null},{"id":10070,"version":2,"created":1554928171000,"modified":1554928174000,"deprecated":false,"name":"Protein FAM126B","accession":"Q8IXS8","gene":"FAM126B","description":"Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.299456441429452,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10070)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(10070)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(10070)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10070)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10070)/publications"},"_namespace":null},{"id":10071,"version":2,"created":1554928175000,"modified":1554928177000,"deprecated":false,"name":"Monocyte to macrophage differentiation factor 2","accession":"Q8IY49","gene":"MMD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0526664813107616,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":9.481423,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.083666904986607,"pubTatorScore":0.5673624906151439,"self":"https://pharos.nih.gov/idg/api/v1/targets(10071)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10071)/properties"},"_links":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(10071)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10071)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10071)/publications"},"_namespace":null},{"id":10072,"version":2,"created":1554928178000,"modified":1554928180000,"deprecated":false,"name":"FERM and PDZ domain-containing protein 4","accession":"Q14CM0","gene":"FRMPD4","description":"Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.28681063575374144,"antibodyCount":31,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.699358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.618919228213855,"pubTatorScore":0.30308368809318803,"self":"https://pharos.nih.gov/idg/api/v1/targets(10072)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10072)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(10072)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10072)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10072)/publications"},"_namespace":null},{"id":10073,"version":2,"created":1554928181000,"modified":1554928184000,"deprecated":false,"name":"Patatin-like phospholipase domain-containing protein 7","accession":"Q6ZV29","gene":"PNPLA7","description":"Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7132104369362119,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.235922,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.934765888730052,"pubTatorScore":0.33579216873772366,"self":"https://pharos.nih.gov/idg/api/v1/targets(10073)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(10073)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(10073)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10073)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10073)/publications"},"_namespace":null},{"id":10074,"version":2,"created":1554928185000,"modified":1554928185000,"deprecated":false,"name":"Uncharacterized protein C9orf57","accession":"Q5W0N0","gene":"C9orf57","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":49,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10074)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10074)/properties"},"_links":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(10074)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10074)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10074)/publications"},"_namespace":null},{"id":10075,"version":4,"created":1554928185000,"modified":1555039156000,"deprecated":false,"name":"Histone deacetylase 3","accession":"O15379","gene":"HDAC3","description":"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).","idgFamily":"Epigenetic","idgTDL":"Tclin","novelty":-2.2845666241309295,"antibodyCount":673,"monoclonalCount":200,"pubmedCount":null,"jensenScore":142.907112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":47.91798993762773,"pubTatorScore":2.440976209992174,"self":"https://pharos.nih.gov/idg/api/v1/targets(10075)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":706,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/properties"},"_links":{"count":1878,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/synonyms"},"_publications":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10075)/publications"},"_namespace":null},{"id":10076,"version":3,"created":1554928221000,"modified":1555039159000,"deprecated":false,"name":"Lethal(3)malignant brain tumor-like protein 2","accession":"Q969R5","gene":"L3MBTL2","description":"Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.7620739092681027,"antibodyCount":149,"monoclonalCount":30,"pubmedCount":null,"jensenScore":6.623742,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":32.29228261272158,"pubTatorScore":0.8277691310110438,"self":"https://pharos.nih.gov/idg/api/v1/targets(10076)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(10076)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(10076)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10076)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10076)/publications"},"_namespace":null},{"id":10077,"version":2,"created":1554928224000,"modified":1554928227000,"deprecated":false,"name":"Oxysterol-binding protein 2","accession":"Q969R2","gene":"OSBP2","description":"Binds 7-ketocholesterol.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.373597008385235,"antibodyCount":91,"monoclonalCount":4,"pubmedCount":null,"jensenScore":222.195083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.11056521469436,"pubTatorScore":1.6529130755115007,"self":"https://pharos.nih.gov/idg/api/v1/targets(10077)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(10077)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(10077)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10077)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10077)/publications"},"_namespace":null},{"id":10078,"version":2,"created":1554928228000,"modified":1554928233000,"deprecated":false,"name":"Transmembrane protease serine 2","accession":"O15393","gene":"TMPRSS2","description":"Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.6668611740175683,"antibodyCount":221,"monoclonalCount":20,"pubmedCount":null,"jensenScore":438.217765,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.67275049727736,"pubTatorScore":2.5890593716663677,"self":"https://pharos.nih.gov/idg/api/v1/targets(10078)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(10078)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(10078)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10078)/synonyms"},"_publications":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(10078)/publications"},"_namespace":null},{"id":10079,"version":2,"created":1554928234000,"modified":1554928237000,"deprecated":false,"name":"Neural cell adhesion molecule 2","accession":"O15394","gene":"NCAM2","description":"May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8988470168899299,"antibodyCount":218,"monoclonalCount":10,"pubmedCount":null,"jensenScore":8.632718,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.21519607677089,"pubTatorScore":1.1053349328803201,"self":"https://pharos.nih.gov/idg/api/v1/targets(10079)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(10079)/properties"},"_links":{"count":924,"href":"https://pharos.nih.gov/idg/api/v1/targets(10079)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10079)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10079)/publications"},"_namespace":null},{"id":10080,"version":2,"created":1554928238000,"modified":1554928240000,"deprecated":false,"name":"Transcription factor YY2","accession":"O15391","gene":"YY2","description":"Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.04900256877747,"antibodyCount":61,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.485895,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.874450892278357,"pubTatorScore":0.9502024991669681,"self":"https://pharos.nih.gov/idg/api/v1/targets(10080)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(10080)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(10080)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10080)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10080)/publications"},"_namespace":null},{"id":10081,"version":3,"created":1554928241000,"modified":1555039161000,"deprecated":false,"name":"Baculoviral IAP repeat-containing protein 5","accession":"O15392","gene":"BIRC5","description":"Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.195316846946816,"antibodyCount":1167,"monoclonalCount":410,"pubmedCount":null,"jensenScore":132.541228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":51.50072590927084,"pubTatorScore":2.903967779097315,"self":"https://pharos.nih.gov/idg/api/v1/targets(10081)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1469,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/properties"},"_links":{"count":2066,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/links"},"_synonyms":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/synonyms"},"_publications":{"count":1088,"href":"https://pharos.nih.gov/idg/api/v1/targets(10081)/publications"},"_namespace":null},{"id":10082,"version":2,"created":1554928260000,"modified":1554928264000,"deprecated":false,"name":"Importin-8","accession":"O15397","gene":"IPO8","description":"Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8008412903679734,"antibodyCount":94,"monoclonalCount":4,"pubmedCount":null,"jensenScore":60.818982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.436437623458055,"pubTatorScore":1.4096082272952857,"self":"https://pharos.nih.gov/idg/api/v1/targets(10082)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(10082)/properties"},"_links":{"count":969,"href":"https://pharos.nih.gov/idg/api/v1/targets(10082)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10082)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10082)/publications"},"_namespace":null},{"id":10083,"version":2,"created":1554928265000,"modified":1554928269000,"deprecated":false,"name":"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma","accession":"Q969Q6","gene":"PPP2R3C","description":"May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.0825267355153187,"antibodyCount":118,"monoclonalCount":3,"pubmedCount":null,"jensenScore":12.153806,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.43381334236233,"pubTatorScore":1.0935606371653093,"self":"https://pharos.nih.gov/idg/api/v1/targets(10083)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(10083)/properties"},"_links":{"count":975,"href":"https://pharos.nih.gov/idg/api/v1/targets(10083)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10083)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10083)/publications"},"_namespace":null},{"id":10084,"version":3,"created":1554928269000,"modified":1555039168000,"deprecated":false,"name":"Intraflagellar transport protein 20 homolog","accession":"Q8IY31","gene":"IFT20","description":"Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.183756511965194,"antibodyCount":90,"monoclonalCount":10,"pubmedCount":null,"jensenScore":15.248231,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":59,"knowledgeAvailability":39.00509176385444,"pubTatorScore":0.5975123270050733,"self":"https://pharos.nih.gov/idg/api/v1/targets(10084)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(10084)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(10084)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10084)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10084)/publications"},"_namespace":null},{"id":10085,"version":2,"created":1554928273000,"modified":1554928277000,"deprecated":false,"name":"MICAL-like protein 2","accession":"Q8IY33","gene":"MICALL2","description":"Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9121714297366822,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":11.227455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.757117747106,"pubTatorScore":0.6954399086616381,"self":"https://pharos.nih.gov/idg/api/v1/targets(10085)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(10085)/properties"},"_links":{"count":945,"href":"https://pharos.nih.gov/idg/api/v1/targets(10085)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10085)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10085)/publications"},"_namespace":null},{"id":10086,"version":2,"created":1554928278000,"modified":1554928281000,"deprecated":false,"name":"Solute carrier family 15 member 3","accession":"Q8IY34","gene":"SLC15A3","description":"Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.424025593530831,"antibodyCount":74,"monoclonalCount":6,"pubmedCount":null,"jensenScore":23.929946,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.070952199938056,"pubTatorScore":0.9400735477056431,"self":"https://pharos.nih.gov/idg/api/v1/targets(10086)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(10086)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(10086)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10086)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10086)/publications"},"_namespace":null},{"id":10087,"version":2,"created":1554928282000,"modified":1554928284000,"deprecated":false,"name":"Protein FAM178B","accession":"Q8IXR5","gene":"FAM178B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.498964243361506,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10087)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(10087)/properties"},"_links":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(10087)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10087)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10087)/publications"},"_namespace":null},{"id":10088,"version":2,"created":1554928284000,"modified":1554928287000,"deprecated":false,"name":"Probable ATP-dependent RNA helicase DHX37","accession":"Q8IY37","gene":"DHX37","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.07525095271530231,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.198052,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.604065515277263,"pubTatorScore":-0.5890946054160394,"self":"https://pharos.nih.gov/idg/api/v1/targets(10088)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(10088)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(10088)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10088)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10088)/publications"},"_namespace":null},{"id":10089,"version":2,"created":1554928287000,"modified":1554928289000,"deprecated":false,"name":"Uncharacterized protein C12orf56","accession":"Q8IXR9","gene":"C12orf56","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10089)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(10089)/properties"},"_links":{"count":602,"href":"https://pharos.nih.gov/idg/api/v1/targets(10089)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10089)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10089)/publications"},"_namespace":null},{"id":10090,"version":2,"created":1554928290000,"modified":1554928293000,"deprecated":false,"name":"Calcium-activated chloride channel regulator 4","accession":"Q14CN2","gene":"CLCA4","description":"May be involved in mediating calcium-activated chloride conductance.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.9593110469462773,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":77.757868,"patentCount":12925,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.312400496988985,"pubTatorScore":0.9972358407537958,"self":"https://pharos.nih.gov/idg/api/v1/targets(10090)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(10090)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(10090)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10090)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10090)/publications"},"_namespace":null},{"id":10091,"version":2,"created":1554928293000,"modified":1554928296000,"deprecated":false,"name":"Keratin, type II cytoskeletal 72","accession":"Q14CN4","gene":"KRT72","description":"Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7915873735216732,"antibodyCount":88,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.560699,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.11492832578346,"pubTatorScore":1.0323464155390603,"self":"https://pharos.nih.gov/idg/api/v1/targets(10091)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(10091)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(10091)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10091)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10091)/publications"},"_namespace":null},{"id":10092,"version":2,"created":1554928296000,"modified":1554928298000,"deprecated":false,"name":"Ras-related protein Rab-24","accession":"Q969Q5","gene":"RAB24","description":"May be involved in autophagy-related processes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2097499610413602,"antibodyCount":174,"monoclonalCount":33,"pubmedCount":null,"jensenScore":17.132288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.919199921519446,"pubTatorScore":1.001256245586277,"self":"https://pharos.nih.gov/idg/api/v1/targets(10092)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(10092)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(10092)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10092)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10092)/publications"},"_namespace":null},{"id":10093,"version":3,"created":1554928300000,"modified":1555039169000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 11","accession":"Q969Q4","gene":"ARL11","description":"May play a role in apoptosis. May act as a tumor suppressor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3177649139109573,"antibodyCount":121,"monoclonalCount":26,"pubmedCount":null,"jensenScore":23.136508,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":18.97965216132168,"pubTatorScore":1.5820001923453857,"self":"https://pharos.nih.gov/idg/api/v1/targets(10093)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10093)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(10093)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10093)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10093)/publications"},"_namespace":null},{"id":10094,"version":3,"created":1554928302000,"modified":1555039171000,"deprecated":false,"name":"Sialic acid-binding Ig-like lectin 5","accession":"O15389","gene":"SIGLEC5","description":"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4531032594624964,"antibodyCount":360,"monoclonalCount":135,"pubmedCount":null,"jensenScore":19.578028,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":20.223588195897282,"pubTatorScore":1.5025448415351454,"self":"https://pharos.nih.gov/idg/api/v1/targets(10094)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10094)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(10094)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10094)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10094)/publications"},"_namespace":null},{"id":10095,"version":2,"created":1554928305000,"modified":1554928308000,"deprecated":false,"name":"E3 ubiquitin-protein ligase TRIM63","accession":"Q969Q1","gene":"TRIM63","description":"E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.295297953372518,"antibodyCount":264,"monoclonalCount":48,"pubmedCount":null,"jensenScore":189.718043,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.02157165400022,"pubTatorScore":2.407862282173126,"self":"https://pharos.nih.gov/idg/api/v1/targets(10095)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(10095)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(10095)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10095)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(10095)/publications"},"_namespace":null},{"id":10096,"version":3,"created":1554928309000,"modified":1555039172000,"deprecated":false,"name":"60S ribosomal protein L36a-like","accession":"Q969Q0","gene":"RPL36AL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8580889592840555,"antibodyCount":94,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.094311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":29.555525431946453,"pubTatorScore":0.5863311529178268,"self":"https://pharos.nih.gov/idg/api/v1/targets(10096)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(10096)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(10096)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10096)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10096)/publications"},"_namespace":null},{"id":10097,"version":2,"created":1554928312000,"modified":1554928315000,"deprecated":false,"name":"TOG array regulator of axonemal microtubules protein 2","accession":"Q6ZUX3","gene":"TOGARAM2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5102896182277844,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.124061,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.9128506139081484,"self":"https://pharos.nih.gov/idg/api/v1/targets(10097)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(10097)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(10097)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10097)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10097)/publications"},"_namespace":null},{"id":10098,"version":3,"created":1554928315000,"modified":1555039174000,"deprecated":false,"name":"LHFPL tetraspan subfamily member 2 protein","accession":"Q6ZUX7","gene":"LHFPL2","description":"Plays a role in female and male fertility. Involved in distal reproductive tract development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.30565839689905394,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.988096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":35.49943180001338,"pubTatorScore":-0.28678927635947304,"self":"https://pharos.nih.gov/idg/api/v1/targets(10098)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10098)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10098)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10098)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10098)/publications"},"_namespace":null},{"id":10099,"version":3,"created":1554928318000,"modified":1555039175000,"deprecated":false,"name":"Endoplasmic reticulum export factor CTAGE5","accession":"O15320","gene":"CTAGE5","description":"Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1669419881796907,"antibodyCount":143,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.363724,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":0.0,"pubTatorScore":1.2155368419586234,"self":"https://pharos.nih.gov/idg/api/v1/targets(10099)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(10099)/properties"},"_links":{"count":1094,"href":"https://pharos.nih.gov/idg/api/v1/targets(10099)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10099)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(10099)/publications"},"_namespace":null},{"id":10100,"version":2,"created":1554928323000,"modified":1554928325000,"deprecated":false,"name":"Peptidyl-prolyl cis-trans isomerase-like 6","accession":"Q8IXY8","gene":"PPIL6","description":"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":119,"monoclonalCount":43,"pubmedCount":null,"jensenScore":0.2,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.202366459848445,"pubTatorScore":0.5939713125729363,"self":"https://pharos.nih.gov/idg/api/v1/targets(10100)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10100)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(10100)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10100)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10100)/publications"},"_namespace":null},{"id":10101,"version":2,"created":1554928325000,"modified":1554928329000,"deprecated":false,"name":"Transmembrane 9 superfamily member 1","accession":"O15321","gene":"TM9SF1","description":"Plays an essential role in autophagy.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.30160105995947306,"antibodyCount":172,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.840057,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.85483342497361,"pubTatorScore":0.5964225731364219,"self":"https://pharos.nih.gov/idg/api/v1/targets(10101)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(10101)/properties"},"_links":{"count":1098,"href":"https://pharos.nih.gov/idg/api/v1/targets(10101)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10101)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10101)/publications"},"_namespace":null},{"id":10102,"version":3,"created":1554928329000,"modified":1555039177000,"deprecated":false,"name":"Coiled-coil domain-containing protein 78","accession":"A2IDD5","gene":"CCDC78","description":"Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3187587626244128,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.924242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":21.48292226727774,"pubTatorScore":0.6532125137753437,"self":"https://pharos.nih.gov/idg/api/v1/targets(10102)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(10102)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(10102)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10102)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10102)/publications"},"_namespace":null},{"id":10103,"version":2,"created":1554928332000,"modified":1554928335000,"deprecated":false,"name":"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6","accession":"Q969X2","gene":"ST6GALNAC6","description":"Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.47821136757512644,"antibodyCount":63,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.239288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.823623583368967,"pubTatorScore":0.4679778752797927,"self":"https://pharos.nih.gov/idg/api/v1/targets(10103)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(10103)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(10103)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10103)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10103)/publications"},"_namespace":null},{"id":10104,"version":2,"created":1554928336000,"modified":1554928340000,"deprecated":false,"name":"Protein lifeguard 3","accession":"Q969X1","gene":"TMBIM1","description":"Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.800187743094208,"antibodyCount":133,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.67376,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.09373756770648,"pubTatorScore":0.6715050573872213,"self":"https://pharos.nih.gov/idg/api/v1/targets(10104)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(10104)/properties"},"_links":{"count":1087,"href":"https://pharos.nih.gov/idg/api/v1/targets(10104)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10104)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10104)/publications"},"_namespace":null},{"id":10105,"version":2,"created":1554928340000,"modified":1554928341000,"deprecated":false,"name":"Immunoglobulin lambda variable 3-27","accession":"P01718","gene":"IGLV3-27","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.9594947495607316,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10105)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10105)/properties"},"_links":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(10105)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10105)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10105)/publications"},"_namespace":null},{"id":10106,"version":2,"created":1554928341000,"modified":1554928341000,"deprecated":false,"name":"Putative uncharacterized protein MGC163334","accession":"Q5W150","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10106)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10106)/properties"},"_links":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10106)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10106)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10106)/publications"},"_namespace":null},{"id":10107,"version":2,"created":1554928341000,"modified":1554928343000,"deprecated":false,"name":"Immunoglobulin lambda variable 3-25","accession":"P01717","gene":"IGLV3-25","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.186041960133584,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10107)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(10107)/properties"},"_links":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(10107)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10107)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10107)/publications"},"_namespace":null},{"id":10108,"version":2,"created":1554928343000,"modified":1554928347000,"deprecated":false,"name":"Phosphorylase b kinase regulatory subunit beta","accession":"Q93100","gene":"PHKB","description":"Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1326145467429418,"antibodyCount":113,"monoclonalCount":10,"pubmedCount":null,"jensenScore":11.55836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.79129301726143,"pubTatorScore":1.1577256633623851,"self":"https://pharos.nih.gov/idg/api/v1/targets(10108)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(10108)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(10108)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10108)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10108)/publications"},"_namespace":null},{"id":10109,"version":2,"created":1554928348000,"modified":1554928349000,"deprecated":false,"name":"Immunoglobulin lambda variable 3-1","accession":"P01715","gene":"IGLV3-1","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.7918426479061202,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10109)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(10109)/properties"},"_links":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(10109)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10109)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10109)/publications"},"_namespace":null},{"id":10110,"version":2,"created":1554928349000,"modified":1554928352000,"deprecated":false,"name":"RILP-like protein 2","accession":"Q969X0","gene":"RILPL2","description":"Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.862743900833682,"antibodyCount":95,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.138666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.13710175726345,"pubTatorScore":0.7488337923639006,"self":"https://pharos.nih.gov/idg/api/v1/targets(10110)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":265,"href":"https://pharos.nih.gov/idg/api/v1/targets(10110)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(10110)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10110)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10110)/publications"},"_namespace":null},{"id":10111,"version":2,"created":1554928353000,"modified":1554928355000,"deprecated":false,"name":"Immunoglobulin lambda variable 3-19","accession":"P01714","gene":"IGLV3-19","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.780859633802411,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10111)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10111)/properties"},"_links":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(10111)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10111)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10111)/publications"},"_namespace":null},{"id":10112,"version":2,"created":1554928355000,"modified":1554928358000,"deprecated":false,"name":"Ventricular zone-expressed PH domain-containing protein homolog 1","accession":"Q14D04","gene":"VEPH1","description":"Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.192461251355728,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.202462,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.910099201642076,"pubTatorScore":0.7514990446174062,"self":"https://pharos.nih.gov/idg/api/v1/targets(10112)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10112)/properties"},"_links":{"count":819,"href":"https://pharos.nih.gov/idg/api/v1/targets(10112)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10112)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10112)/publications"},"_namespace":null},{"id":10113,"version":2,"created":1554928359000,"modified":1554928361000,"deprecated":false,"name":"SH2 domain-containing protein 5","accession":"Q6ZV89","gene":"SH2D5","description":"May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.760386565627948,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.963608,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.57719092691784,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10113)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(10113)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(10113)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10113)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10113)/publications"},"_namespace":null},{"id":10114,"version":2,"created":1554928362000,"modified":1554928365000,"deprecated":false,"name":"Sodium/potassium/calcium exchanger 4","accession":"Q8NFF2","gene":"SLC24A4","description":"Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.3205362165190961,"antibodyCount":63,"monoclonalCount":2,"pubmedCount":null,"jensenScore":20.7597,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.133712643811066,"pubTatorScore":1.1101597816927309,"self":"https://pharos.nih.gov/idg/api/v1/targets(10114)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(10114)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(10114)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10114)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10114)/publications"},"_namespace":null},{"id":10115,"version":2,"created":1554928366000,"modified":1554928369000,"deprecated":false,"name":"FAD synthase","accession":"Q8NFF5","gene":"FLAD1","description":"Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5733044872208366,"antibodyCount":112,"monoclonalCount":2,"pubmedCount":null,"jensenScore":36.932407,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.41354015501394,"pubTatorScore":1.4412030282538748,"self":"https://pharos.nih.gov/idg/api/v1/targets(10115)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(10115)/properties"},"_links":{"count":1098,"href":"https://pharos.nih.gov/idg/api/v1/targets(10115)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10115)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10115)/publications"},"_namespace":null},{"id":10116,"version":3,"created":1554928370000,"modified":1555039178000,"deprecated":false,"name":"U3 small nucleolar RNA-associated protein 4 homolog","accession":"Q969X6","gene":"UTP4","description":"Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6709669998736605,"antibodyCount":87,"monoclonalCount":11,"pubmedCount":null,"jensenScore":46.349379,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":0.0,"pubTatorScore":1.1749638160546212,"self":"https://pharos.nih.gov/idg/api/v1/targets(10116)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10116)/publications"},"_namespace":null},{"id":10117,"version":3,"created":1554928374000,"modified":1555039179000,"deprecated":false,"name":"Endoplasmic reticulum-Golgi intermediate compartment protein 1","accession":"Q969X5","gene":"ERGIC1","description":"Possible role in transport between endoplasmic reticulum and Golgi.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0997956940073033,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.057539,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":40.13883828235986,"pubTatorScore":0.04792368195730733,"self":"https://pharos.nih.gov/idg/api/v1/targets(10117)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10117)/publications"},"_namespace":null},{"id":10118,"version":3,"created":1554928379000,"modified":1555039180000,"deprecated":false,"name":"DNA-directed RNA polymerase III subunit RPC7","accession":"O15318","gene":"POLR3G","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1769177256129648,"antibodyCount":85,"monoclonalCount":3,"pubmedCount":null,"jensenScore":14.159892,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.92806896139975,"pubTatorScore":0.7323327934666588,"self":"https://pharos.nih.gov/idg/api/v1/targets(10118)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/properties"},"_links":{"count":850,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10118)/publications"},"_namespace":null},{"id":10119,"version":3,"created":1554928383000,"modified":1555039181000,"deprecated":false,"name":"DNA repair protein RAD51 homolog 2","accession":"O15315","gene":"RAD51B","description":"Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9456420822101401,"antibodyCount":171,"monoclonalCount":51,"pubmedCount":null,"jensenScore":84.795957,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.89443439861342,"pubTatorScore":1.8467557755408657,"self":"https://pharos.nih.gov/idg/api/v1/targets(10119)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":477,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/properties"},"_links":{"count":1085,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10119)/publications"},"_namespace":null},{"id":10120,"version":2,"created":1554928388000,"modified":1554928391000,"deprecated":false,"name":"Structure-specific endonuclease subunit SLX4","accession":"Q8IY92","gene":"SLX4","description":"Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.687942874268222,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":61.732779,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.6984828820373,"pubTatorScore":1.625631622425185,"self":"https://pharos.nih.gov/idg/api/v1/targets(10120)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10120)/publications"},"_namespace":null},{"id":10121,"version":3,"created":1554928392000,"modified":1555039183000,"deprecated":false,"name":"Transmembrane protein 183A","accession":"Q8IXX5","gene":"TMEM183A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.049797469484342556,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.467533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.489395428757657,"pubTatorScore":0.3473300153169504,"self":"https://pharos.nih.gov/idg/api/v1/targets(10121)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10121)/publications"},"_namespace":null},{"id":10122,"version":2,"created":1554928395000,"modified":1554928398000,"deprecated":false,"name":"Transmembrane protein 192","accession":"Q8IY95","gene":"TMEM192","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5513919097592981,"antibodyCount":55,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.044257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.320772933624156,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(10122)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10122)/publications"},"_namespace":null},{"id":10123,"version":3,"created":1554928399000,"modified":1555039184000,"deprecated":false,"name":"Postacrosomal sheath WW domain-binding protein","accession":"Q6ICG8","gene":"WBP2NL","description":"May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9615849147809674,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":89.432168,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":21.07298902292309,"pubTatorScore":1.6720386235212576,"self":"https://pharos.nih.gov/idg/api/v1/targets(10123)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/properties"},"_links":{"count":733,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10123)/publications"},"_namespace":null},{"id":10124,"version":2,"created":1554928401000,"modified":1554928407000,"deprecated":false,"name":"Delta-aminolevulinic acid dehydratase","accession":"P13716","gene":"ALAD","description":"Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.0202422675251954,"antibodyCount":166,"monoclonalCount":7,"pubmedCount":null,"jensenScore":1068.562629,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.76361702420024,"pubTatorScore":2.894803662206195,"self":"https://pharos.nih.gov/idg/api/v1/targets(10124)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/properties"},"_links":{"count":1128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/synonyms"},"_publications":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10124)/publications"},"_namespace":null},{"id":10125,"version":3,"created":1554928408000,"modified":1555039185000,"deprecated":false,"name":"Palmitoyltransferase ZDHHC16","accession":"Q969W1","gene":"ZDHHC16","description":"Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4890204838099633,"antibodyCount":91,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.19994158977682,"pubTatorScore":1.2844307112837665,"self":"https://pharos.nih.gov/idg/api/v1/targets(10125)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10125)/publications"},"_namespace":null},{"id":10126,"version":2,"created":1554928412000,"modified":1554928412000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-8","accession":"P01709","gene":"IGLV2-8","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.138721289330153,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(10126)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10126)/publications"},"_namespace":null},{"id":10127,"version":3,"created":1554928412000,"modified":1555039186000,"deprecated":false,"name":"Serine palmitoyltransferase small subunit A","accession":"Q969W0","gene":"SPTSSA","description":"Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.35856932111570794,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.200534,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.045156427748775,"pubTatorScore":0.22617003740008312,"self":"https://pharos.nih.gov/idg/api/v1/targets(10127)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10127)/publications"},"_namespace":null},{"id":10128,"version":2,"created":1554928415000,"modified":1554928417000,"deprecated":false,"name":"Protein FAM104A","accession":"Q969W3","gene":"FAM104A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.581691998746727,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10128)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10128)/publications"},"_namespace":null},{"id":10129,"version":2,"created":1554928418000,"modified":1554928420000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-11","accession":"P01706","gene":"IGLV2-11","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.4303302292068714,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10129)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/properties"},"_links":{"count":448,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10129)/publications"},"_namespace":null},{"id":10130,"version":2,"created":1554928421000,"modified":1554928422000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-23","accession":"P01705","gene":"IGLV2-23","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.5239746753089545,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10130)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/properties"},"_links":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10130)/publications"},"_namespace":null},{"id":10131,"version":2,"created":1554928422000,"modified":1554928423000,"deprecated":false,"name":"Immunoglobulin lambda variable 2-14","accession":"P01704","gene":"IGLV2-14","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.991284812390269,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10131)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/properties"},"_links":{"count":561,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10131)/publications"},"_namespace":null},{"id":10132,"version":2,"created":1554928424000,"modified":1554928425000,"deprecated":false,"name":"Immunoglobulin lambda variable 1-40","accession":"P01703","gene":"IGLV1-40","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.605291313050428,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10132)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/properties"},"_links":{"count":504,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10132)/publications"},"_namespace":null},{"id":10133,"version":3,"created":1554928425000,"modified":1555039187000,"deprecated":false,"name":"B box and SPRY domain-containing protein","accession":"Q5W0U4","gene":"BSPRY","description":"May regulate epithelial calcium transport by inhibiting TRPV5 activity.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3127894657031628,"antibodyCount":41,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.241612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":28.37661650212082,"pubTatorScore":0.4756711883244297,"self":"https://pharos.nih.gov/idg/api/v1/targets(10133)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10133)/publications"},"_namespace":null},{"id":10134,"version":2,"created":1554928429000,"modified":1554928432000,"deprecated":false,"name":"Protein TMEPAI","accession":"Q969W9","gene":"PMEPA1","description":"Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3552705011391046,"antibodyCount":90,"monoclonalCount":22,"pubmedCount":null,"jensenScore":24.764944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.244645794818304,"pubTatorScore":1.4028348743444177,"self":"https://pharos.nih.gov/idg/api/v1/targets(10134)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10134)/publications"},"_namespace":null},{"id":10135,"version":2,"created":1554928433000,"modified":1554928434000,"deprecated":false,"name":"Immunoglobulin lambda variable 1-51","accession":"P01701","gene":"IGLV1-51","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.97288281161112,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10135)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10135)/properties"},"_links":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(10135)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10135)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10135)/publications"},"_namespace":null},{"id":10136,"version":2,"created":1554928435000,"modified":1554928436000,"deprecated":false,"name":"Immunoglobulin lambda variable 1-47","accession":"P01700","gene":"IGLV1-47","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.832842199924929,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10136)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10136)/properties"},"_links":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(10136)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10136)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10136)/publications"},"_namespace":null},{"id":10137,"version":2,"created":1554928437000,"modified":1554928439000,"deprecated":false,"name":"Zinc finger protein 566","accession":"Q969W8","gene":"ZNF566","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":83,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.870424416866346,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10137)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(10137)/properties"},"_links":{"count":841,"href":"https://pharos.nih.gov/idg/api/v1/targets(10137)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10137)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10137)/publications"},"_namespace":null},{"id":10138,"version":3,"created":1554928440000,"modified":1555039189000,"deprecated":false,"name":"Uncharacterized protein KIAA0930","accession":"Q6ICG6","gene":"KIAA0930","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7201593044916931,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.291209,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":29.83866815094523,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10138)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10138)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(10138)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10138)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10138)/publications"},"_namespace":null},{"id":10139,"version":2,"created":1554928443000,"modified":1554928447000,"deprecated":false,"name":"Type II inositol 3,4-bisphosphate 4-phosphatase","accession":"O15327","gene":"INPP4B","description":"Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5517563496203153,"antibodyCount":79,"monoclonalCount":24,"pubmedCount":null,"jensenScore":41.553319,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.870687531815854,"pubTatorScore":1.5219704637796858,"self":"https://pharos.nih.gov/idg/api/v1/targets(10139)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(10139)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(10139)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10139)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(10139)/publications"},"_namespace":null},{"id":10140,"version":2,"created":1554928448000,"modified":1554928451000,"deprecated":false,"name":"pre-rRNA processing protein FTSJ3","accession":"Q8IY81","gene":"FTSJ3","description":"Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6292395791712961,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":42.283145,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.013519499205636,"pubTatorScore":1.3349561161368517,"self":"https://pharos.nih.gov/idg/api/v1/targets(10140)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(10140)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(10140)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10140)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10140)/publications"},"_namespace":null},{"id":10141,"version":2,"created":1554928452000,"modified":1554928454000,"deprecated":false,"name":"Dynein regulatory complex subunit 7","accession":"Q8IY82","gene":"DRC7","description":"Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.22847932792314973,"antibodyCount":52,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.933824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.90114854429002,"pubTatorScore":0.10266245618515422,"self":"https://pharos.nih.gov/idg/api/v1/targets(10141)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(10141)/properties"},"_links":{"count":723,"href":"https://pharos.nih.gov/idg/api/v1/targets(10141)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10141)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10141)/publications"},"_namespace":null},{"id":10142,"version":2,"created":1554928455000,"modified":1554928457000,"deprecated":false,"name":"LanC-like protein 3","accession":"Q6ZV70","gene":"LANCL3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.06634401996718672,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.419802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.743074599173006,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10142)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(10142)/properties"},"_links":{"count":826,"href":"https://pharos.nih.gov/idg/api/v1/targets(10142)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10142)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10142)/publications"},"_namespace":null},{"id":10143,"version":2,"created":1554928458000,"modified":1554928458000,"deprecated":false,"name":"Putative cytosolic acyl coenzyme A thioester hydrolase-like","accession":"Q6ZUV0","gene":"ACOT7L","description":"Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10143)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10143)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10143)/links"},"_synonyms":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10143)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10143)/publications"},"_namespace":null},{"id":10144,"version":2,"created":1554928458000,"modified":1554928462000,"deprecated":false,"name":"AT-rich interactive domain-containing protein 1B","accession":"Q8NFD5","gene":"ARID1B","description":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.8830427696894472,"antibodyCount":120,"monoclonalCount":31,"pubmedCount":null,"jensenScore":66.852756,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.84750289918134,"pubTatorScore":1.6965770888129976,"self":"https://pharos.nih.gov/idg/api/v1/targets(10144)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":470,"href":"https://pharos.nih.gov/idg/api/v1/targets(10144)/properties"},"_links":{"count":1080,"href":"https://pharos.nih.gov/idg/api/v1/targets(10144)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10144)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10144)/publications"},"_namespace":null},{"id":10145,"version":2,"created":1554928463000,"modified":1554928466000,"deprecated":false,"name":"Serine/threonine-protein kinase NIM1","accession":"Q8IY84","gene":"NIM1K","description":null,"idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.323865664471142,"antibodyCount":101,"monoclonalCount":3,"pubmedCount":null,"jensenScore":20.874523,"patentCount":8450,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.04399209048805,"pubTatorScore":0.7659166946993106,"self":"https://pharos.nih.gov/idg/api/v1/targets(10145)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10145)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(10145)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10145)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10145)/publications"},"_namespace":null},{"id":10146,"version":2,"created":1554928467000,"modified":1554928469000,"deprecated":false,"name":"EF-hand calcium-binding domain-containing protein 13","accession":"Q8IY85","gene":"EFCAB13","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":75,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.77672113214328,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(10146)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(10146)/properties"},"_links":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(10146)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10146)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10146)/publications"},"_namespace":null},{"id":10147,"version":3,"created":1554928470000,"modified":1555039190000,"deprecated":false,"name":"V-type proton ATPase subunit e 1","accession":"O15342","gene":"ATP6V0E1","description":"Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.8583366438706318,"antibodyCount":11,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.671428,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.045046189925145,"pubTatorScore":0.7377226198094055,"self":"https://pharos.nih.gov/idg/api/v1/targets(10147)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(10147)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(10147)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10147)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10147)/publications"},"_namespace":null},{"id":10148,"version":3,"created":1554928473000,"modified":1555039191000,"deprecated":false,"name":"Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2","accession":"Q8IXW5","gene":"RPAP2","description":"Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1212783945834701,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.15291,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.383958875145996,"pubTatorScore":1.0040141200231942,"self":"https://pharos.nih.gov/idg/api/v1/targets(10148)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(10148)/properties"},"_links":{"count":984,"href":"https://pharos.nih.gov/idg/api/v1/targets(10148)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10148)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10148)/publications"},"_namespace":null},{"id":10149,"version":3,"created":1554928477000,"modified":1555039192000,"deprecated":false,"name":"FYVE, RhoGEF and PH domain-containing protein 6","accession":"Q6ZV73","gene":"FGD6","description":"May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.530565577048732,"antibodyCount":79,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.533273,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.95617505637361,"pubTatorScore":0.42661453634865787,"self":"https://pharos.nih.gov/idg/api/v1/targets(10149)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(10149)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(10149)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10149)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10149)/publications"},"_namespace":null},{"id":10150,"version":2,"created":1554928481000,"modified":1554928484000,"deprecated":false,"name":"SUMO-specific isopeptidase USPL1","accession":"Q5W0Q7","gene":"USPL1","description":"SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.37413709530229633,"antibodyCount":15,"monoclonalCount":5,"pubmedCount":null,"jensenScore":2.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.994150346977776,"pubTatorScore":0.6842467175639678,"self":"https://pharos.nih.gov/idg/api/v1/targets(10150)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10150)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(10150)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10150)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10150)/publications"},"_namespace":null},{"id":10151,"version":3,"created":1554928484000,"modified":1555039194000,"deprecated":false,"name":"Enhancer of rudimentary homolog","accession":"P84090","gene":"ERH","description":"May have a role in the cell cycle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2569184694128204,"antibodyCount":184,"monoclonalCount":51,"pubmedCount":null,"jensenScore":182.213282,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":37.2890422425611,"pubTatorScore":1.183744232766619,"self":"https://pharos.nih.gov/idg/api/v1/targets(10151)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10151)/properties"},"_links":{"count":1071,"href":"https://pharos.nih.gov/idg/api/v1/targets(10151)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10151)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10151)/publications"},"_namespace":null},{"id":10152,"version":3,"created":1554928488000,"modified":1555039195000,"deprecated":false,"name":"ADP-ribosylation factor 5","accession":"P84085","gene":"ARF5","description":"GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4071627511290512,"antibodyCount":185,"monoclonalCount":31,"pubmedCount":null,"jensenScore":23.070284,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":36.88066536060353,"pubTatorScore":1.5723044545177172,"self":"https://pharos.nih.gov/idg/api/v1/targets(10152)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(10152)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(10152)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10152)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10152)/publications"},"_namespace":null},{"id":10153,"version":3,"created":1554928491000,"modified":1555039196000,"deprecated":false,"name":"Melanin-concentrating hormone receptor 2","accession":"Q969V1","gene":"MCHR2","description":"Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.9538881828642083,"antibodyCount":127,"monoclonalCount":0,"pubmedCount":null,"jensenScore":81.844293,"patentCount":14023,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":17.971240289856198,"pubTatorScore":1.7466094870341637,"self":"https://pharos.nih.gov/idg/api/v1/targets(10153)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(10153)/properties"},"_links":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(10153)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10153)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10153)/publications"},"_namespace":null},{"id":10154,"version":2,"created":1554928495000,"modified":1554928498000,"deprecated":false,"name":"F-box only protein 31","accession":"Q5XUX0","gene":"FBXO31","description":"Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3862016097437383,"antibodyCount":157,"monoclonalCount":32,"pubmedCount":null,"jensenScore":2.027522,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.13112765418956,"pubTatorScore":1.0596625711193937,"self":"https://pharos.nih.gov/idg/api/v1/targets(10154)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(10154)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(10154)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10154)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10154)/publications"},"_namespace":null},{"id":10155,"version":3,"created":1554928498000,"modified":1555039197000,"deprecated":false,"name":"T-cell receptor alpha chain V region PY14","accession":"P01737","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10155)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10155)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10155)/links"},"_synonyms":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10155)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10155)/publications"},"_namespace":null},{"id":10156,"version":2,"created":1554928499000,"modified":1554928501000,"deprecated":false,"name":"F-box/WD repeat-containing protein 9","accession":"Q5XUX1","gene":"FBXW9","description":"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":75,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.255521092292184,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10156)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10156)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(10156)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10156)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10156)/publications"},"_namespace":null},{"id":10157,"version":3,"created":1554928501000,"modified":1555039197000,"deprecated":false,"name":"Chondroadherin","accession":"O15335","gene":"CHAD","description":"Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9953614061305431,"antibodyCount":73,"monoclonalCount":8,"pubmedCount":null,"jensenScore":100.344923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":23.727425100895786,"pubTatorScore":1.7007998309308359,"self":"https://pharos.nih.gov/idg/api/v1/targets(10157)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(10157)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(10157)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10157)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10157)/publications"},"_namespace":null},{"id":10158,"version":2,"created":1554928505000,"modified":1554928509000,"deprecated":false,"name":"Cytochrome c oxidase subunit 2","accession":"P00403","gene":"MT-CO2","description":"Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.9601775583916625,"antibodyCount":127,"monoclonalCount":28,"pubmedCount":null,"jensenScore":880.379875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.8612452450994343,"self":"https://pharos.nih.gov/idg/api/v1/targets(10158)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(10158)/properties"},"_links":{"count":1185,"href":"https://pharos.nih.gov/idg/api/v1/targets(10158)/links"},"_synonyms":{"count":614,"href":"https://pharos.nih.gov/idg/api/v1/targets(10158)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10158)/publications"},"_namespace":null},{"id":10159,"version":2,"created":1554928511000,"modified":1554928511000,"deprecated":false,"name":"T-cell receptor beta chain V region YT35","accession":"P01733","gene":"TRBV12-3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.8320194874720199,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10159)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(10159)/properties"},"_links":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10159)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(10159)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10159)/publications"},"_namespace":null},{"id":10160,"version":2,"created":1554928511000,"modified":1554928514000,"deprecated":false,"name":"T-cell surface glycoprotein CD8 alpha chain","accession":"P01732","gene":"CD8A","description":"Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3717153131350277,"antibodyCount":3514,"monoclonalCount":2995,"pubmedCount":null,"jensenScore":222.627563,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.769419511127005,"pubTatorScore":4.1740884018319235,"self":"https://pharos.nih.gov/idg/api/v1/targets(10160)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(10160)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(10160)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10160)/synonyms"},"_publications":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(10160)/publications"},"_namespace":null},{"id":10161,"version":2,"created":1554928515000,"modified":1554928517000,"deprecated":false,"name":"Protein FAM47E","accession":"Q6ZV65","gene":"FAM47E-STBD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.17609125905568124,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.666667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.438501880019384,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10161)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(10161)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(10161)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10161)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10161)/publications"},"_namespace":null},{"id":10162,"version":2,"created":1554928518000,"modified":1554928520000,"deprecated":false,"name":"Tektin-1","accession":"Q969V4","gene":"TEKT1","description":"Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9129457112947499,"antibodyCount":109,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.424329,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.99217754429265,"pubTatorScore":0.5503739090642426,"self":"https://pharos.nih.gov/idg/api/v1/targets(10162)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/properties"},"_links":{"count":727,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10162)/publications"},"_namespace":null},{"id":10163,"version":2,"created":1554928521000,"modified":1554928522000,"deprecated":false,"name":"Putative dispanin subfamily A member 2d","accession":"C9JQL5","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.932557529051246,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":151.247483,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10163)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/properties"},"_links":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/links"},"_synonyms":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10163)/publications"},"_namespace":null},{"id":10164,"version":3,"created":1554928522000,"modified":1555039198000,"deprecated":false,"name":"T-cell surface glycoprotein CD4","accession":"P01730","gene":"CD4","description":"(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.6276183071612,"antibodyCount":4422,"monoclonalCount":3807,"pubmedCount":null,"jensenScore":407.909257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":46.00758150519637,"pubTatorScore":4.540309834110986,"self":"https://pharos.nih.gov/idg/api/v1/targets(10164)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/properties"},"_links":{"count":1222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/links"},"_synonyms":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/synonyms"},"_publications":{"count":414,"href":"https://pharos.nih.gov/idg/api/v1/targets(10164)/publications"},"_namespace":null},{"id":10165,"version":3,"created":1554928531000,"modified":1555039201000,"deprecated":false,"name":"Nicalin","accession":"Q969V3","gene":"NCLN","description":"May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0283854779743529,"antibodyCount":94,"monoclonalCount":6,"pubmedCount":null,"jensenScore":11.276094,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.238104696915755,"pubTatorScore":0.7061485604848146,"self":"https://pharos.nih.gov/idg/api/v1/targets(10165)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10165)/publications"},"_namespace":null},{"id":10166,"version":2,"created":1554928535000,"modified":1554928535000,"deprecated":false,"name":"Uncharacterized protein FLJ76381","accession":"Q8NFD4","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10166)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/properties"},"_links":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10166)/publications"},"_namespace":null},{"id":10167,"version":3,"created":1554928535000,"modified":1555039202000,"deprecated":false,"name":"MKL/myocardin-like protein 1","accession":"Q969V6","gene":"MKL1","description":"Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5170435654789096,"antibodyCount":199,"monoclonalCount":38,"pubmedCount":null,"jensenScore":351.752405,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.29775247089428,"pubTatorScore":1.946722175712949,"self":"https://pharos.nih.gov/idg/api/v1/targets(10167)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":488,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/synonyms"},"_publications":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10167)/publications"},"_namespace":null},{"id":10168,"version":2,"created":1554928539000,"modified":1554928542000,"deprecated":false,"name":"Ankyrin repeat and protein kinase domain-containing protein 1","accession":"Q8NFD2","gene":"ANKK1","description":null,"idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.0801131989233697,"antibodyCount":75,"monoclonalCount":0,"pubmedCount":null,"jensenScore":103.732022,"patentCount":1555,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.643103278567576,"pubTatorScore":2.051606931123645,"self":"https://pharos.nih.gov/idg/api/v1/targets(10168)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/synonyms"},"_publications":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10168)/publications"},"_namespace":null},{"id":10169,"version":2,"created":1554928543000,"modified":1554928546000,"deprecated":false,"name":"Mitochondrial ubiquitin ligase activator of NFKB 1","accession":"Q969V5","gene":"MUL1","description":"Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitchondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitchondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.417104090427629,"antibodyCount":150,"monoclonalCount":7,"pubmedCount":null,"jensenScore":245.784311,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.37532103407905,"pubTatorScore":1.665257034743187,"self":"https://pharos.nih.gov/idg/api/v1/targets(10169)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10169)/publications"},"_namespace":null},{"id":10170,"version":2,"created":1554928547000,"modified":1554928549000,"deprecated":false,"name":"Lamin tail domain-containing protein 2","accession":"Q8IXW0","gene":"LMNTD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.907430140987692,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10170)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10170)/publications"},"_namespace":null},{"id":10171,"version":2,"created":1554928549000,"modified":1554928553000,"deprecated":false,"name":"Biorientation of chromosomes in cell division protein 1-like 1","accession":"Q8NFC6","gene":"BOD1L1","description":"Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2218487496163564,"antibodyCount":22,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.861111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.969643287574286,"pubTatorScore":0.16136800223497488,"self":"https://pharos.nih.gov/idg/api/v1/targets(10171)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/properties"},"_links":{"count":1059,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10171)/publications"},"_namespace":null},{"id":10172,"version":2,"created":1554928554000,"modified":1554928558000,"deprecated":false,"name":"Tumor protein p73","accession":"O15350","gene":"TP73","description":"Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.9283234110304306,"antibodyCount":708,"monoclonalCount":273,"pubmedCount":null,"jensenScore":82.594326,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.94600053007851,"pubTatorScore":2.90574915693978,"self":"https://pharos.nih.gov/idg/api/v1/targets(10172)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":909,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/properties"},"_links":{"count":1357,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/links"},"_synonyms":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/synonyms"},"_publications":{"count":545,"href":"https://pharos.nih.gov/idg/api/v1/targets(10172)/publications"},"_namespace":null},{"id":10173,"version":2,"created":1554928561000,"modified":1554928562000,"deprecated":false,"name":"Uncharacterized protein C2orf91","accession":"Q6ZV80","gene":"C2orf91","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10173)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/properties"},"_links":{"count":582,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/links"},"_synonyms":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10173)/publications"},"_namespace":null},{"id":10174,"version":2,"created":1554928562000,"modified":1554928565000,"deprecated":false,"name":"Forkhead box protein N1","accession":"O15353","gene":"FOXN1","description":"Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.302057012615302,"antibodyCount":204,"monoclonalCount":5,"pubmedCount":null,"jensenScore":196.381041,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.606973480773778,"pubTatorScore":1.7445695289032133,"self":"https://pharos.nih.gov/idg/api/v1/targets(10174)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/properties"},"_links":{"count":698,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10174)/publications"},"_namespace":null},{"id":10175,"version":3,"created":1554928566000,"modified":1555039204000,"deprecated":false,"name":"Prosaposin receptor GPR37","accession":"O15354","gene":"GPR37","description":"Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.527391704000663,"antibodyCount":191,"monoclonalCount":23,"pubmedCount":null,"jensenScore":42.52928,"patentCount":3177,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":34.53953985878102,"pubTatorScore":1.5193435049676647,"self":"https://pharos.nih.gov/idg/api/v1/targets(10175)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10175)/publications"},"_namespace":null},{"id":10176,"version":2,"created":1554928570000,"modified":1554928572000,"deprecated":false,"name":"Kelch domain-containing protein 8B","accession":"Q8IXV7","gene":"KLHDC8B","description":"Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5740312622990379,"antibodyCount":113,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.630953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.326397494456742,"pubTatorScore":0.876987165211168,"self":"https://pharos.nih.gov/idg/api/v1/targets(10176)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/properties"},"_links":{"count":906,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10176)/publications"},"_namespace":null},{"id":10177,"version":2,"created":1554928573000,"modified":1554928576000,"deprecated":false,"name":"Neuron-specific calcium-binding protein hippocalcin","accession":"P84074","gene":"HPCA","description":"Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.771961190467475,"antibodyCount":80,"monoclonalCount":7,"pubmedCount":null,"jensenScore":62.87417,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.066923721551397,"pubTatorScore":1.3318178239416372,"self":"https://pharos.nih.gov/idg/api/v1/targets(10177)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(10177)/properties"},"_links":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(10177)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10177)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10177)/publications"},"_namespace":null},{"id":10178,"version":2,"created":1554928577000,"modified":1554928579000,"deprecated":false,"name":"Receptor-transporting protein 5","accession":"Q14D33","gene":"RTP5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.722935512304809,"pubTatorScore":-1.2041199826559248,"self":"https://pharos.nih.gov/idg/api/v1/targets(10178)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(10178)/properties"},"_links":{"count":686,"href":"https://pharos.nih.gov/idg/api/v1/targets(10178)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10178)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10178)/publications"},"_namespace":null},{"id":10179,"version":3,"created":1554928580000,"modified":1555039205000,"deprecated":false,"name":"ADP-ribosylation factor 1","accession":"P84077","gene":"ARF1","description":"GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.5342885773941646,"antibodyCount":288,"monoclonalCount":127,"pubmedCount":null,"jensenScore":374.359593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":50.710581460477115,"pubTatorScore":2.4884332183097913,"self":"https://pharos.nih.gov/idg/api/v1/targets(10179)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":527,"href":"https://pharos.nih.gov/idg/api/v1/targets(10179)/properties"},"_links":{"count":1276,"href":"https://pharos.nih.gov/idg/api/v1/targets(10179)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10179)/synonyms"},"_publications":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(10179)/publications"},"_namespace":null},{"id":10180,"version":3,"created":1554928586000,"modified":1555039207000,"deprecated":false,"name":"Proteasome assembly chaperone 2","accession":"Q969U7","gene":"PSMG2","description":"Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.054357682589669,"antibodyCount":149,"monoclonalCount":26,"pubmedCount":null,"jensenScore":11.166666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":33.418372730571775,"pubTatorScore":1.5215738992359804,"self":"https://pharos.nih.gov/idg/api/v1/targets(10180)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10180)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(10180)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10180)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10180)/publications"},"_namespace":null},{"id":10181,"version":2,"created":1554928590000,"modified":1554928592000,"deprecated":false,"name":"F-box/WD repeat-containing protein 5","accession":"Q969U6","gene":"FBXW5","description":"Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.48379100500581657,"antibodyCount":107,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.500484,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.692476528637034,"pubTatorScore":0.5976428700301942,"self":"https://pharos.nih.gov/idg/api/v1/targets(10181)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10181)/publications"},"_namespace":null},{"id":10182,"version":3,"created":1554928593000,"modified":1555039209000,"deprecated":false,"name":"High mobility group protein B3","accession":"O15347","gene":"HMGB3","description":"Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.487990778675097,"antibodyCount":199,"monoclonalCount":20,"pubmedCount":null,"jensenScore":33.115366,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.55945410494074,"pubTatorScore":1.2963920911086544,"self":"https://pharos.nih.gov/idg/api/v1/targets(10182)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":305,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10182)/publications"},"_namespace":null},{"id":10183,"version":3,"created":1554928597000,"modified":1555039210000,"deprecated":false,"name":"Uncharacterized protein C9orf139","accession":"Q6ZV77","gene":"C9orf139","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10183)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/properties"},"_links":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10183)/publications"},"_namespace":null},{"id":10184,"version":2,"created":1554928598000,"modified":1554928602000,"deprecated":false,"name":"E3 ubiquitin-protein ligase Midline-1","accession":"O15344","gene":"MID1","description":"Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.640985331851828,"antibodyCount":171,"monoclonalCount":9,"pubmedCount":null,"jensenScore":44.833377,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.0803356727565,"pubTatorScore":1.9834206002126769,"self":"https://pharos.nih.gov/idg/api/v1/targets(10184)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":396,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/properties"},"_links":{"count":1118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10184)/publications"},"_namespace":null},{"id":10185,"version":2,"created":1554928603000,"modified":1554928604000,"deprecated":false,"name":"Immunoglobulin lambda variable 6-57","accession":"P01721","gene":"IGLV6-57","description":"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.36156289753645,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10185)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10185)/properties"},"_links":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(10185)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10185)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10185)/publications"},"_namespace":null},{"id":10186,"version":2,"created":1554928605000,"modified":1554928607000,"deprecated":false,"name":"Pleckstrin homology domain-containing family A member 4","accession":"Q9H4M7","gene":"PLEKHA4","description":"Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.6020599913279624,"antibodyCount":96,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.85577080751769,"pubTatorScore":-0.4648869792587226,"self":"https://pharos.nih.gov/idg/api/v1/targets(10186)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(10186)/properties"},"_links":{"count":910,"href":"https://pharos.nih.gov/idg/api/v1/targets(10186)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10186)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10186)/publications"},"_namespace":null},{"id":10187,"version":3,"created":1554928608000,"modified":1555039210000,"deprecated":false,"name":"F-box only protein 44","accession":"Q9H4M3","gene":"FBXO44","description":"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.40150994951987184,"antibodyCount":181,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.069736,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.26189126073109,"pubTatorScore":0.3579999862874149,"self":"https://pharos.nih.gov/idg/api/v1/targets(10187)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":355,"href":"https://pharos.nih.gov/idg/api/v1/targets(10187)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(10187)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10187)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10187)/publications"},"_namespace":null},{"id":10188,"version":2,"created":1554928611000,"modified":1554928613000,"deprecated":false,"name":"Autophagy-related protein 9B","accession":"Q674R7","gene":"ATG9B","description":"Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":142,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.371069046397757,"pubTatorScore":0.8485312432097827,"self":"https://pharos.nih.gov/idg/api/v1/targets(10188)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(10188)/properties"},"_links":{"count":685,"href":"https://pharos.nih.gov/idg/api/v1/targets(10188)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10188)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10188)/publications"},"_namespace":null},{"id":10189,"version":2,"created":1554928614000,"modified":1554928616000,"deprecated":false,"name":"Serine/threonine-protein kinase/endoribonuclease IRE2","accession":"Q76MJ5","gene":"ERN2","description":"Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.297926265809231,"antibodyCount":175,"monoclonalCount":3,"pubmedCount":null,"jensenScore":19.914637,"patentCount":1890,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.30536003794278,"pubTatorScore":0.8791322508570037,"self":"https://pharos.nih.gov/idg/api/v1/targets(10189)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(10189)/properties"},"_links":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(10189)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10189)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10189)/publications"},"_namespace":null},{"id":10190,"version":2,"created":1554928617000,"modified":1554928618000,"deprecated":false,"name":"Meiosis expressed gene 1 protein homolog","accession":"Q5JSS6","gene":"MEIG1","description":"Essential for spermiogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.19188552747975451,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.742857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.487629779376395,"pubTatorScore":0.38171653659895594,"self":"https://pharos.nih.gov/idg/api/v1/targets(10190)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(10190)/properties"},"_links":{"count":668,"href":"https://pharos.nih.gov/idg/api/v1/targets(10190)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10190)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10190)/publications"},"_namespace":null},{"id":10191,"version":3,"created":1554928619000,"modified":1555039211000,"deprecated":false,"name":"Suppressor of cytokine signaling 6","accession":"O14544","gene":"SOCS6","description":"SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9228371155595425,"antibodyCount":154,"monoclonalCount":11,"pubmedCount":null,"jensenScore":79.5116,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":38.804247466448444,"pubTatorScore":2.3884104285405994,"self":"https://pharos.nih.gov/idg/api/v1/targets(10191)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(10191)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(10191)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10191)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10191)/publications"},"_namespace":null},{"id":10192,"version":3,"created":1554928623000,"modified":1555039212000,"deprecated":false,"name":"Suppressor of cytokine signaling 3","accession":"O14543","gene":"SOCS3","description":"SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0565697921380584,"antibodyCount":518,"monoclonalCount":210,"pubmedCount":null,"jensenScore":1157.161448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":48.941241738162994,"pubTatorScore":2.819613460523095,"self":"https://pharos.nih.gov/idg/api/v1/targets(10192)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":795,"href":"https://pharos.nih.gov/idg/api/v1/targets(10192)/properties"},"_links":{"count":1346,"href":"https://pharos.nih.gov/idg/api/v1/targets(10192)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10192)/synonyms"},"_publications":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(10192)/publications"},"_namespace":null},{"id":10193,"version":2,"created":1554928631000,"modified":1554928633000,"deprecated":false,"name":"Mpv17-like protein 2","accession":"Q567V2","gene":"MPV17L2","description":"Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.23888208807995504,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.74359,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.334383088325072,"pubTatorScore":0.19629476358790166,"self":"https://pharos.nih.gov/idg/api/v1/targets(10193)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(10193)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(10193)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10193)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10193)/publications"},"_namespace":null},{"id":10194,"version":3,"created":1554928633000,"modified":1555039215000,"deprecated":false,"name":"TRAF-type zinc finger domain-containing protein 1","accession":"O14545","gene":"TRAFD1","description":"Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4580379968449846,"antibodyCount":143,"monoclonalCount":45,"pubmedCount":null,"jensenScore":3.974392,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":37.36340320411664,"pubTatorScore":0.3671314464760054,"self":"https://pharos.nih.gov/idg/api/v1/targets(10194)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(10194)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(10194)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10194)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10194)/publications"},"_namespace":null},{"id":10195,"version":2,"created":1554928637000,"modified":1554928639000,"deprecated":false,"name":"Cytochrome c oxidase subunit 7A-related protein, mitochondrial","accession":"O14548","gene":"COX7A2L","description":"Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9213373577421111,"antibodyCount":110,"monoclonalCount":4,"pubmedCount":null,"jensenScore":8.98653,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.052544701774025,"pubTatorScore":0.9562120979352662,"self":"https://pharos.nih.gov/idg/api/v1/targets(10195)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10195)/properties"},"_links":{"count":963,"href":"https://pharos.nih.gov/idg/api/v1/targets(10195)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10195)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10195)/publications"},"_namespace":null},{"id":10196,"version":2,"created":1554928640000,"modified":1554928644000,"deprecated":false,"name":"Oxysterol-binding protein-related protein 3","accession":"Q9H4L5","gene":"OSBPL3","description":"Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7951978695684083,"antibodyCount":74,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.142689,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.40400742851292,"pubTatorScore":1.015569976830878,"self":"https://pharos.nih.gov/idg/api/v1/targets(10196)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(10196)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(10196)/links"},"_synonyms":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(10196)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10196)/publications"},"_namespace":null},{"id":10197,"version":2,"created":1554928644000,"modified":1554928647000,"deprecated":false,"name":"Kinesin-like protein KIF19","accession":"Q2TAC6","gene":"KIF19","description":"Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5502283543579776,"antibodyCount":55,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.266667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.447290958317772,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(10197)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(10197)/properties"},"_links":{"count":785,"href":"https://pharos.nih.gov/idg/api/v1/targets(10197)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10197)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10197)/publications"},"_namespace":null},{"id":10198,"version":2,"created":1554928648000,"modified":1554928651000,"deprecated":false,"name":"Sentrin-specific protease 3","accession":"Q9H4L4","gene":"SENP3","description":"Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8988381058859678,"antibodyCount":191,"monoclonalCount":8,"pubmedCount":null,"jensenScore":78.898937,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.266404624901284,"pubTatorScore":1.4303750216737672,"self":"https://pharos.nih.gov/idg/api/v1/targets(10198)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(10198)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(10198)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10198)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10198)/publications"},"_namespace":null},{"id":10199,"version":2,"created":1554928651000,"modified":1554928655000,"deprecated":false,"name":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1","accession":"Q9H4L7","gene":"SMARCAD1","description":"DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1684360664659894,"antibodyCount":95,"monoclonalCount":2,"pubmedCount":null,"jensenScore":16.422731,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.50779631228978,"pubTatorScore":1.5169318220764823,"self":"https://pharos.nih.gov/idg/api/v1/targets(10199)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(10199)/properties"},"_links":{"count":1122,"href":"https://pharos.nih.gov/idg/api/v1/targets(10199)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10199)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10199)/publications"},"_namespace":null},{"id":10200,"version":3,"created":1554928656000,"modified":1555039218000,"deprecated":false,"name":"Prolyl 4-hydroxylase subunit alpha-3","accession":"Q7Z4N8","gene":"P4HA3","description":"Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.484634392730374,"antibodyCount":89,"monoclonalCount":6,"pubmedCount":null,"jensenScore":2.864358,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":53,"knowledgeAvailability":28.987047452609367,"pubTatorScore":-0.29759703868270415,"self":"https://pharos.nih.gov/idg/api/v1/targets(10200)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(10200)/properties"},"_links":{"count":775,"href":"https://pharos.nih.gov/idg/api/v1/targets(10200)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10200)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10200)/publications"},"_namespace":null},{"id":10201,"version":2,"created":1554928659000,"modified":1554928662000,"deprecated":false,"name":"Ubiquitin domain-containing protein UBFD1","accession":"O14562","gene":"UBFD1","description":"May play a role as NF-kappa-B regulator.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.1139433523068367,"antibodyCount":122,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.055556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.713256864633248,"pubTatorScore":-1.1139437866015358,"self":"https://pharos.nih.gov/idg/api/v1/targets(10201)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(10201)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(10201)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10201)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10201)/publications"},"_namespace":null},{"id":10202,"version":3,"created":1554928662000,"modified":1555039219000,"deprecated":false,"name":"Acyl carrier protein, mitochondrial","accession":"O14561","gene":"NDUFAB1","description":"Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-2.678221427501805,"antibodyCount":67,"monoclonalCount":12,"pubmedCount":null,"jensenScore":475.149069,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":43.032330809244534,"pubTatorScore":1.0553145970417959,"self":"https://pharos.nih.gov/idg/api/v1/targets(10202)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(10202)/properties"},"_links":{"count":1093,"href":"https://pharos.nih.gov/idg/api/v1/targets(10202)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10202)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10202)/publications"},"_namespace":null},{"id":10203,"version":2,"created":1554928669000,"modified":1554928671000,"deprecated":false,"name":"EF-hand domain-containing family member C2","accession":"Q5JST6","gene":"EFHC2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8689871079888755,"antibodyCount":87,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.870437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.58517085350382,"pubTatorScore":0.9522510047703475,"self":"https://pharos.nih.gov/idg/api/v1/targets(10203)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":206,"href":"https://pharos.nih.gov/idg/api/v1/targets(10203)/properties"},"_links":{"count":778,"href":"https://pharos.nih.gov/idg/api/v1/targets(10203)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10203)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10203)/publications"},"_namespace":null},{"id":10204,"version":2,"created":1554928672000,"modified":1554928675000,"deprecated":false,"name":"Transient receptor potential cation channel subfamily M member 1","accession":"Q7Z4N2","gene":"TRPM1","description":"Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-1.9492553267534838,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":88.584713,"patentCount":4688,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.17385580095622,"pubTatorScore":1.7448301195854334,"self":"https://pharos.nih.gov/idg/api/v1/targets(10204)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(10204)/properties"},"_links":{"count":691,"href":"https://pharos.nih.gov/idg/api/v1/targets(10204)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10204)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10204)/publications"},"_namespace":null},{"id":10205,"version":2,"created":1554928675000,"modified":1554928678000,"deprecated":false,"name":"GTPase-activating Rap/Ran-GAP domain-like protein 3","accession":"Q5VVW2","gene":"GARNL3","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.764182774837387,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10205)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(10205)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(10205)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10205)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10205)/publications"},"_namespace":null},{"id":10206,"version":2,"created":1554928679000,"modified":1554928682000,"deprecated":false,"name":"Coiled-coil domain-containing protein 93","accession":"Q567U6","gene":"CCDC93","description":"Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2588956164904856,"antibodyCount":156,"monoclonalCount":110,"pubmedCount":null,"jensenScore":1.050271,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.642725000538697,"pubTatorScore":-0.4423592820895424,"self":"https://pharos.nih.gov/idg/api/v1/targets(10206)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(10206)/properties"},"_links":{"count":1007,"href":"https://pharos.nih.gov/idg/api/v1/targets(10206)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10206)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10206)/publications"},"_namespace":null},{"id":10207,"version":3,"created":1554928683000,"modified":1555039220000,"deprecated":false,"name":"Ras-related protein Rab-40A-like","accession":"P0C0E4","gene":"RAB40AL","description":"May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.880904195559967,"antibodyCount":48,"monoclonalCount":0,"pubmedCount":null,"jensenScore":60.337023,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":16.695472539908632,"pubTatorScore":1.0184230273258903,"self":"https://pharos.nih.gov/idg/api/v1/targets(10207)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(10207)/properties"},"_links":{"count":625,"href":"https://pharos.nih.gov/idg/api/v1/targets(10207)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10207)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10207)/publications"},"_namespace":null},{"id":10208,"version":3,"created":1554928686000,"modified":1555039221000,"deprecated":false,"name":"Mitochondrial ribosome-associated GTPase 2","accession":"Q9H4K7","gene":"MTG2","description":"Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5835765776718839,"antibodyCount":104,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.07619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":30.788014108106964,"pubTatorScore":0.6989700043360189,"self":"https://pharos.nih.gov/idg/api/v1/targets(10208)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(10208)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(10208)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10208)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10208)/publications"},"_namespace":null},{"id":10209,"version":2,"created":1554928689000,"modified":1554928691000,"deprecated":false,"name":"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","accession":"O14556","gene":"GAPDHS","description":"May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.794639707924073,"antibodyCount":151,"monoclonalCount":53,"pubmedCount":null,"jensenScore":53.953452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.41252793374291,"pubTatorScore":1.445665965208057,"self":"https://pharos.nih.gov/idg/api/v1/targets(10209)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(10209)/properties"},"_links":{"count":581,"href":"https://pharos.nih.gov/idg/api/v1/targets(10209)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10209)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10209)/publications"},"_namespace":null},{"id":10210,"version":2,"created":1554928692000,"modified":1554928695000,"deprecated":false,"name":"Rho GTPase-activating protein 33","accession":"O14559","gene":"ARHGAP33","description":"May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7919833363770153,"antibodyCount":114,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.420921,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.33958119839304,"pubTatorScore":0.4573772470232607,"self":"https://pharos.nih.gov/idg/api/v1/targets(10210)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(10210)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(10210)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10210)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10210)/publications"},"_namespace":null},{"id":10211,"version":3,"created":1554928696000,"modified":1555039223000,"deprecated":false,"name":"Heat shock protein beta-6","accession":"O14558","gene":"HSPB6","description":"Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3447799024443614,"antibodyCount":231,"monoclonalCount":53,"pubmedCount":null,"jensenScore":237.766048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":32.333541908745396,"pubTatorScore":1.988729774016988,"self":"https://pharos.nih.gov/idg/api/v1/targets(10211)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(10211)/properties"},"_links":{"count":982,"href":"https://pharos.nih.gov/idg/api/v1/targets(10211)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10211)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(10211)/publications"},"_namespace":null},{"id":10212,"version":3,"created":1554928702000,"modified":1555039224000,"deprecated":false,"name":"Mitotic-spindle organizing protein 2B","accession":"Q6NZ67","gene":"MZT2B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":26.140288665227153,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10212)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(10212)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(10212)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10212)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10212)/publications"},"_namespace":null},{"id":10213,"version":2,"created":1554928705000,"modified":1554928707000,"deprecated":false,"name":"Pentraxin-4","accession":"Q96A99","gene":"PTX4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0437364098878588,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.35119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.076443610902606,"pubTatorScore":1.0071785561487958,"self":"https://pharos.nih.gov/idg/api/v1/targets(10213)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10213)/properties"},"_links":{"count":647,"href":"https://pharos.nih.gov/idg/api/v1/targets(10213)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10213)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10213)/publications"},"_namespace":null},{"id":10214,"version":3,"created":1554928707000,"modified":1555039225000,"deprecated":false,"name":"Tuberoinfundibular peptide of 39 residues","accession":"Q96A98","gene":"PTH2","description":"Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.54592536192793,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":44.061331,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":15.658395319763926,"pubTatorScore":1.5372846975025567,"self":"https://pharos.nih.gov/idg/api/v1/targets(10214)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10214)/properties"},"_links":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(10214)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(10214)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10214)/publications"},"_namespace":null},{"id":10215,"version":3,"created":1554928709000,"modified":1555039225000,"deprecated":false,"name":"RIB43A-like with coiled-coils protein 2","accession":"Q9H4K1","gene":"RIBC2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.6129855377836593,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.36355,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.29992124248169,"pubTatorScore":0.9712537158591945,"self":"https://pharos.nih.gov/idg/api/v1/targets(10215)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(10215)/properties"},"_links":{"count":718,"href":"https://pharos.nih.gov/idg/api/v1/targets(10215)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10215)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10215)/publications"},"_namespace":null},{"id":10216,"version":2,"created":1554928711000,"modified":1554928713000,"deprecated":false,"name":"Meiotic recombination protein REC114","accession":"Q7Z4M0","gene":"REC114","description":"Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.13867854719540104,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.203688,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.608030625282305,"pubTatorScore":0.308208509095282,"self":"https://pharos.nih.gov/idg/api/v1/targets(10216)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10216)/properties"},"_links":{"count":531,"href":"https://pharos.nih.gov/idg/api/v1/targets(10216)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10216)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10216)/publications"},"_namespace":null},{"id":10217,"version":2,"created":1554928713000,"modified":1554928713000,"deprecated":false,"name":"Putative uncharacterized protein C1orf140","accession":"Q5VVS0","gene":"C1orf140","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10217)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10217)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10217)/links"},"_synonyms":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10217)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10217)/publications"},"_namespace":null},{"id":10218,"version":2,"created":1554928713000,"modified":1554928714000,"deprecated":false,"name":"Putative KHDC1-like protein","accession":"Q5JSQ8","gene":"KHDC1L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.93159421245691,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10218)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10218)/properties"},"_links":{"count":547,"href":"https://pharos.nih.gov/idg/api/v1/targets(10218)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10218)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10218)/publications"},"_namespace":null},{"id":10219,"version":3,"created":1554928715000,"modified":1555039227000,"deprecated":false,"name":"Ras-related protein Rab-41","accession":"Q5JT25","gene":"RAB41","description":"Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":119,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":12.797331100633661,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(10219)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(10219)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(10219)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10219)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10219)/publications"},"_namespace":null},{"id":10220,"version":3,"created":1554928717000,"modified":1555039228000,"deprecated":false,"name":"STEAP family member 1B","accession":"Q6NZ63","gene":"STEAP1B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.214286,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":14.154428680844033,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10220)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(10220)/properties"},"_links":{"count":731,"href":"https://pharos.nih.gov/idg/api/v1/targets(10220)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(10220)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10220)/publications"},"_namespace":null},{"id":10221,"version":2,"created":1554928720000,"modified":1554928722000,"deprecated":false,"name":"Cytochrome b561 domain-containing protein 2","accession":"O14569","gene":"CYB561D2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7776339143551424,"antibodyCount":106,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.884713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.99991959707877,"pubTatorScore":0.5975122172885495,"self":"https://pharos.nih.gov/idg/api/v1/targets(10221)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(10221)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(10221)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10221)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10221)/publications"},"_namespace":null},{"id":10222,"version":3,"created":1554928723000,"modified":1555039228000,"deprecated":false,"name":"Tetratricopeptide repeat protein 21B","accession":"Q7Z4L5","gene":"TTC21B","description":"Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negatively modulates the SHH signal transduction (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.223930454605748,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.412872,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.33346392185818,"pubTatorScore":0.9092553420469868,"self":"https://pharos.nih.gov/idg/api/v1/targets(10222)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(10222)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(10222)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10222)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10222)/publications"},"_namespace":null},{"id":10223,"version":2,"created":1554928727000,"modified":1554928729000,"deprecated":false,"name":"Protein phosphatase 1 regulatory subunit 42","accession":"Q7Z4L9","gene":"PPP1R42","description":"Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.42596873227228116,"antibodyCount":79,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.485714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.96974864589278,"pubTatorScore":0.5411035058941378,"self":"https://pharos.nih.gov/idg/api/v1/targets(10223)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(10223)/properties"},"_links":{"count":639,"href":"https://pharos.nih.gov/idg/api/v1/targets(10223)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10223)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10223)/publications"},"_namespace":null},{"id":10224,"version":2,"created":1554928729000,"modified":1554928730000,"deprecated":false,"name":"Olfactory receptor 7A17","accession":"O14581","gene":"OR7A17","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":1.2304489213782739,"antibodyCount":19,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.04,"patentCount":471,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.236359785350515,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10224)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(10224)/properties"},"_links":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10224)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10224)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10224)/publications"},"_namespace":null},{"id":10225,"version":2,"created":1554928730000,"modified":1554928732000,"deprecated":false,"name":"Cytochrome c oxidase subunit 8C, mitochondrial","accession":"Q7Z4L0","gene":"COX8C","description":"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.21559980189040656,"antibodyCount":12,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.252937852332558,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10225)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(10225)/properties"},"_links":{"count":740,"href":"https://pharos.nih.gov/idg/api/v1/targets(10225)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10225)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10225)/publications"},"_namespace":null},{"id":10226,"version":2,"created":1554928733000,"modified":1554928736000,"deprecated":false,"name":"TATA element modulatory factor","accession":"P82094","gene":"TMF1","description":"Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3170926432354024,"antibodyCount":60,"monoclonalCount":1,"pubmedCount":null,"jensenScore":210.197682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.50975760096777,"pubTatorScore":1.4604145603513798,"self":"https://pharos.nih.gov/idg/api/v1/targets(10226)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(10226)/properties"},"_links":{"count":1052,"href":"https://pharos.nih.gov/idg/api/v1/targets(10226)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10226)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10226)/publications"},"_namespace":null},{"id":10227,"version":3,"created":1554928737000,"modified":1555039229000,"deprecated":false,"name":"Essential MCU regulator, mitochondrial","accession":"Q9H4I9","gene":"SMDT1","description":"Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6073506986680872,"antibodyCount":11,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.416982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":23.849520457832053,"pubTatorScore":1.7713424652822414,"self":"https://pharos.nih.gov/idg/api/v1/targets(10227)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10227)/properties"},"_links":{"count":974,"href":"https://pharos.nih.gov/idg/api/v1/targets(10227)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10227)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10227)/publications"},"_namespace":null},{"id":10228,"version":3,"created":1554928740000,"modified":1555039231000,"deprecated":false,"name":"EMI domain-containing protein 1","accession":"Q96A84","gene":"EMID1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2290273375006884,"antibodyCount":77,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.5519,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":28.619212992762705,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(10228)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10228)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(10228)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10228)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10228)/publications"},"_namespace":null},{"id":10229,"version":3,"created":1554928743000,"modified":1555039232000,"deprecated":false,"name":"Cytoplasmic dynein 1 intermediate chain 1","accession":"O14576","gene":"DYNC1I1","description":"Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.748925998819267,"antibodyCount":92,"monoclonalCount":10,"pubmedCount":null,"jensenScore":5.970481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":36.178856858061025,"pubTatorScore":0.7789546753909928,"self":"https://pharos.nih.gov/idg/api/v1/targets(10229)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/properties"},"_links":{"count":1132,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10229)/publications"},"_namespace":null},{"id":10230,"version":2,"created":1554928749000,"modified":1554928751000,"deprecated":false,"name":"Collagen alpha-1(XXVI) chain","accession":"Q96A83","gene":"COL26A1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":119,"monoclonalCount":14,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.399380213072398,"pubTatorScore":0.8864907251724818,"self":"https://pharos.nih.gov/idg/api/v1/targets(10230)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/properties"},"_links":{"count":674,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10230)/publications"},"_namespace":null},{"id":10231,"version":3,"created":1554928752000,"modified":1555039233000,"deprecated":false,"name":"Coatomer subunit epsilon","accession":"O14579","gene":"COPE","description":"The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6309404424872787,"antibodyCount":112,"monoclonalCount":3,"pubmedCount":null,"jensenScore":43.012223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.95822693804714,"pubTatorScore":3.112486381054891,"self":"https://pharos.nih.gov/idg/api/v1/targets(10231)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/properties"},"_links":{"count":1221,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10231)/publications"},"_namespace":null},{"id":10232,"version":2,"created":1554928757000,"modified":1554928761000,"deprecated":false,"name":"Citron Rho-interacting kinase","accession":"O14578","gene":"CIT","description":"Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-0.6961028746748188,"antibodyCount":117,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.693085,"patentCount":163984,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.6360677860659,"pubTatorScore":1.3603665518863925,"self":"https://pharos.nih.gov/idg/api/v1/targets(10232)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10232)/publications"},"_namespace":null},{"id":10233,"version":3,"created":1554928762000,"modified":1555039235000,"deprecated":false,"name":"Serine hydrolase-like protein 2","accession":"Q9H4I8","gene":"SERHL2","description":"Probable serine hydrolase. May be related to cell muscle hypertrophy.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.28969258586728874,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.96908,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":23.922883981999068,"pubTatorScore":-1.1760890875887005,"self":"https://pharos.nih.gov/idg/api/v1/targets(10233)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10233)/publications"},"_namespace":null},{"id":10234,"version":2,"created":1554928765000,"modified":1554928768000,"deprecated":false,"name":"Phosphatidate phosphatase LPIN2","accession":"Q92539","gene":"LPIN2","description":"Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.506390843603847,"antibodyCount":152,"monoclonalCount":10,"pubmedCount":null,"jensenScore":30.922481,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.53282603741445,"pubTatorScore":1.3106687830381085,"self":"https://pharos.nih.gov/idg/api/v1/targets(10234)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10234)/publications"},"_namespace":null},{"id":10235,"version":2,"created":1554928769000,"modified":1554928773000,"deprecated":false,"name":"Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1","accession":"Q92538","gene":"GBF1","description":"Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:12047556, PubMed:12808027, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.607582667656062,"antibodyCount":61,"monoclonalCount":5,"pubmedCount":null,"jensenScore":4.310628,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.06302813767754,"pubTatorScore":1.7940618176885683,"self":"https://pharos.nih.gov/idg/api/v1/targets(10235)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/properties"},"_links":{"count":1112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10235)/publications"},"_namespace":null},{"id":10236,"version":2,"created":1554928774000,"modified":1554928774000,"deprecated":false,"name":"Putative uncharacterized protein LOC645739","accession":"Q9H521","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10236)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10236)/publications"},"_namespace":null},{"id":10237,"version":2,"created":1554928774000,"modified":1554928777000,"deprecated":false,"name":"PR domain zinc finger protein 12","accession":"Q9H4Q4","gene":"PRDM12","description":"Involved in the positive regulation of histone H3-K9 dimethylation.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-0.9602895115363744,"antibodyCount":105,"monoclonalCount":6,"pubmedCount":null,"jensenScore":10.485485,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.77109184204066,"pubTatorScore":0.8702087801161407,"self":"https://pharos.nih.gov/idg/api/v1/targets(10237)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/properties"},"_links":{"count":621,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10237)/publications"},"_namespace":null},{"id":10238,"version":2,"created":1554928777000,"modified":1554928782000,"deprecated":false,"name":"Kinesin-like protein KIF21A","accession":"Q7Z4S6","gene":"KIF21A","description":"Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6829576209992174,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":54.139252,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.208549005146885,"pubTatorScore":1.8041475386355044,"self":"https://pharos.nih.gov/idg/api/v1/targets(10238)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(10238)/properties"},"_links":{"count":1200,"href":"https://pharos.nih.gov/idg/api/v1/targets(10238)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10238)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10238)/publications"},"_namespace":null},{"id":10239,"version":2,"created":1554928783000,"modified":1554928785000,"deprecated":false,"name":"PR domain zinc finger protein 13","accession":"Q9H4Q3","gene":"PRDM13","description":"May be involved in transcriptional regulation.","idgFamily":"TF/Epigenetic","idgTDL":"Tbio","novelty":-0.9420080693083567,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.568007,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.315223732043552,"pubTatorScore":0.5808707139727479,"self":"https://pharos.nih.gov/idg/api/v1/targets(10239)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10239)/properties"},"_links":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(10239)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10239)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10239)/publications"},"_namespace":null},{"id":10240,"version":3,"created":1554928785000,"modified":1555039236000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RING1","accession":"Q06587","gene":"RING1","description":"Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.283679403226036,"antibodyCount":475,"monoclonalCount":250,"pubmedCount":null,"jensenScore":171.773673,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":42.869143888653724,"pubTatorScore":1.8312155246183135,"self":"https://pharos.nih.gov/idg/api/v1/targets(10240)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10240)/publications"},"_namespace":null},{"id":10241,"version":2,"created":1554928789000,"modified":1554928790000,"deprecated":false,"name":"HERV-H LTR-associating protein 1","accession":"C9JL84","gene":"HHLA1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.23408320494763177,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.777778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.721000441952036,"pubTatorScore":0.31875869313729016,"self":"https://pharos.nih.gov/idg/api/v1/targets(10241)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/properties"},"_links":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/links"},"_synonyms":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10241)/publications"},"_namespace":null},{"id":10242,"version":2,"created":1554928790000,"modified":1554928792000,"deprecated":false,"name":"Krueppel-like factor 17","accession":"Q5JT82","gene":"KLF17","description":"Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1866918153506418,"antibodyCount":137,"monoclonalCount":0,"pubmedCount":null,"jensenScore":18.788738,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.086219144609057,"pubTatorScore":1.2266714999034065,"self":"https://pharos.nih.gov/idg/api/v1/targets(10242)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10242)/properties"},"_links":{"count":612,"href":"https://pharos.nih.gov/idg/api/v1/targets(10242)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10242)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10242)/publications"},"_namespace":null},{"id":10243,"version":2,"created":1554928793000,"modified":1554928794000,"deprecated":false,"name":"SH2 domain-containing protein 6","accession":"Q7Z4S9","gene":"SH2D6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.021869123008994,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10243)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10243)/properties"},"_links":{"count":685,"href":"https://pharos.nih.gov/idg/api/v1/targets(10243)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10243)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10243)/publications"},"_namespace":null},{"id":10244,"version":3,"created":1554928795000,"modified":1555039238000,"deprecated":false,"name":"Suppressor of cytokine signaling 2","accession":"O14508","gene":"SOCS2","description":"SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.908413930690372,"antibodyCount":196,"monoclonalCount":16,"pubmedCount":null,"jensenScore":804.720056,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.06647987926179,"pubTatorScore":2.5651563425513078,"self":"https://pharos.nih.gov/idg/api/v1/targets(10244)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":494,"href":"https://pharos.nih.gov/idg/api/v1/targets(10244)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(10244)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(10244)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10244)/publications"},"_namespace":null},{"id":10245,"version":2,"created":1554928800000,"modified":1554928803000,"deprecated":false,"name":"MAM domain-containing glycosylphosphatidylinositol anchor protein 2","accession":"Q7Z553","gene":"MDGA2","description":"May be involved in cell-cell interactions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0230564019126795,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.881136,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.746663300112925,"pubTatorScore":1.13858990082473,"self":"https://pharos.nih.gov/idg/api/v1/targets(10245)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10245)/properties"},"_links":{"count":551,"href":"https://pharos.nih.gov/idg/api/v1/targets(10245)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10245)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10245)/publications"},"_namespace":null},{"id":10246,"version":2,"created":1554928804000,"modified":1554928810000,"deprecated":false,"name":"GRB10-interacting GYF protein 2","accession":"Q6Y7W6","gene":"GIGYF2","description":"Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-1.5296531729693112,"antibodyCount":43,"monoclonalCount":1,"pubmedCount":null,"jensenScore":37.144515,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.55748361425117,"pubTatorScore":1.7303361440230653,"self":"https://pharos.nih.gov/idg/api/v1/targets(10246)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(10246)/properties"},"_links":{"count":1211,"href":"https://pharos.nih.gov/idg/api/v1/targets(10246)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10246)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10246)/publications"},"_namespace":null},{"id":10247,"version":3,"created":1554928811000,"modified":1555039239000,"deprecated":false,"name":"Proteasome inhibitor PI31 subunit","accession":"Q92530","gene":"PSMF1","description":"Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.304360570177294,"antibodyCount":165,"monoclonalCount":30,"pubmedCount":null,"jensenScore":21.460075,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":40.49714674058417,"pubTatorScore":1.0749817920117635,"self":"https://pharos.nih.gov/idg/api/v1/targets(10247)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(10247)/properties"},"_links":{"count":1119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10247)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(10247)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10247)/publications"},"_namespace":null},{"id":10248,"version":3,"created":1554928816000,"modified":1555039241000,"deprecated":false,"name":"Sushi domain-containing protein 6","accession":"Q92537","gene":"SUSD6","description":"May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7373914536699814,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.940792,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.499495823392024,"pubTatorScore":0.273276816864615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10248)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(10248)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(10248)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10248)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10248)/publications"},"_namespace":null},{"id":10249,"version":2,"created":1554928820000,"modified":1554928823000,"deprecated":false,"name":"Y+L amino acid transporter 2","accession":"Q92536","gene":"SLC7A6","description":"Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.4842813648524753,"antibodyCount":64,"monoclonalCount":0,"pubmedCount":null,"jensenScore":28.592726,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.93508830936362,"pubTatorScore":1.02580849549754,"self":"https://pharos.nih.gov/idg/api/v1/targets(10249)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(10249)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(10249)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10249)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10249)/publications"},"_namespace":null},{"id":10250,"version":2,"created":1554928824000,"modified":1554928827000,"deprecated":false,"name":"Phosphatidylinositol N-acetylglucosaminyltransferase subunit C","accession":"Q92535","gene":"PIGC","description":"Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6274072103449222,"antibodyCount":50,"monoclonalCount":10,"pubmedCount":null,"jensenScore":41.262355,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.07419813470642,"pubTatorScore":1.1751608729958776,"self":"https://pharos.nih.gov/idg/api/v1/targets(10250)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(10250)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(10250)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10250)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10250)/publications"},"_namespace":null},{"id":10251,"version":2,"created":1554928828000,"modified":1554928833000,"deprecated":false,"name":"Class E basic helix-loop-helix protein 40","accession":"O14503","gene":"BHLHE40","description":"Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.778410775434986,"antibodyCount":224,"monoclonalCount":34,"pubmedCount":null,"jensenScore":66.557253,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.61477928120217,"pubTatorScore":1.6214660299104224,"self":"https://pharos.nih.gov/idg/api/v1/targets(10251)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(10251)/properties"},"_links":{"count":999,"href":"https://pharos.nih.gov/idg/api/v1/targets(10251)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10251)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10251)/publications"},"_namespace":null},{"id":10252,"version":2,"created":1554928834000,"modified":1554928838000,"deprecated":false,"name":"SHC-transforming protein 3","accession":"Q92529","gene":"SHC3","description":"Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.976648754753177,"antibodyCount":137,"monoclonalCount":10,"pubmedCount":null,"jensenScore":99.414516,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.36137540161893,"pubTatorScore":1.5314268113521563,"self":"https://pharos.nih.gov/idg/api/v1/targets(10252)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(10252)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(10252)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10252)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10252)/publications"},"_namespace":null},{"id":10253,"version":2,"created":1554928839000,"modified":1554928842000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 7","accession":"Q92527","gene":"ANKRD7","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.1995723530956438,"antibodyCount":61,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.844156,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.22873778710877,"pubTatorScore":0.43555612041870156,"self":"https://pharos.nih.gov/idg/api/v1/targets(10253)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10253)/properties"},"_links":{"count":756,"href":"https://pharos.nih.gov/idg/api/v1/targets(10253)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10253)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10253)/publications"},"_namespace":null},{"id":10254,"version":3,"created":1554928843000,"modified":1555039242000,"deprecated":false,"name":"E3 ubiquitin-protein ligase NRDP1","accession":"Q9H4P4","gene":"RNF41","description":"Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5898830586117632,"antibodyCount":148,"monoclonalCount":11,"pubmedCount":null,"jensenScore":44.950969,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":38.791037845587894,"pubTatorScore":1.553015622196028,"self":"https://pharos.nih.gov/idg/api/v1/targets(10254)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(10254)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(10254)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10254)/synonyms"},"_publications":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(10254)/publications"},"_namespace":null},{"id":10255,"version":2,"created":1554928847000,"modified":1554928850000,"deprecated":false,"name":"Kelch-like protein 31","accession":"Q9H511","gene":"KLHL31","description":"Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.40782850748475213,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.235712,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.375968068725406,"pubTatorScore":0.37891674543057763,"self":"https://pharos.nih.gov/idg/api/v1/targets(10255)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(10255)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(10255)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10255)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10255)/publications"},"_namespace":null},{"id":10256,"version":2,"created":1554928850000,"modified":1554928853000,"deprecated":false,"name":"UPF0669 protein C6orf120","accession":"Q7Z4R8","gene":"C6orf120","description":"May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2755336070552925,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.100399,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.13845743735703214,"self":"https://pharos.nih.gov/idg/api/v1/targets(10256)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10256)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(10256)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10256)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10256)/publications"},"_namespace":null},{"id":10257,"version":3,"created":1554928854000,"modified":1555039244000,"deprecated":false,"name":"Cyclin-dependent kinase 2-associated protein 1","accession":"O14519","gene":"CDK2AP1","description":"specific inhibitor of the cell-cycle kinase CDK2.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.047180444657301,"antibodyCount":118,"monoclonalCount":11,"pubmedCount":null,"jensenScore":111.122947,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":34.016864857020856,"pubTatorScore":1.6679848479249098,"self":"https://pharos.nih.gov/idg/api/v1/targets(10257)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(10257)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(10257)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10257)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10257)/publications"},"_namespace":null},{"id":10258,"version":2,"created":1554928857000,"modified":1554928860000,"deprecated":false,"name":"Histone H1x","accession":"Q92522","gene":"H1FX","description":"Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.723123171903789,"antibodyCount":68,"monoclonalCount":3,"pubmedCount":null,"jensenScore":52.822878,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.39788882104815,"pubTatorScore":1.0910804576096438,"self":"https://pharos.nih.gov/idg/api/v1/targets(10258)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(10258)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(10258)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10258)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10258)/publications"},"_namespace":null},{"id":10259,"version":2,"created":1554928861000,"modified":1554928864000,"deprecated":false,"name":"GPI mannosyltransferase 3","accession":"Q92521","gene":"PIGB","description":"Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3039157203822074,"antibodyCount":79,"monoclonalCount":8,"pubmedCount":null,"jensenScore":19.138054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.17368941354511,"pubTatorScore":0.620780249111653,"self":"https://pharos.nih.gov/idg/api/v1/targets(10259)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10259)/properties"},"_links":{"count":865,"href":"https://pharos.nih.gov/idg/api/v1/targets(10259)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10259)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10259)/publications"},"_namespace":null},{"id":10260,"version":2,"created":1554928865000,"modified":1554928868000,"deprecated":false,"name":"Pro-neuregulin-2, membrane-bound isoform","accession":"O14511","gene":"NRG2","description":"Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4697978677048729,"antibodyCount":141,"monoclonalCount":35,"pubmedCount":null,"jensenScore":31.995499,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.76589196577455,"pubTatorScore":1.3877059808516379,"self":"https://pharos.nih.gov/idg/api/v1/targets(10260)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(10260)/properties"},"_links":{"count":841,"href":"https://pharos.nih.gov/idg/api/v1/targets(10260)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10260)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10260)/publications"},"_namespace":null},{"id":10261,"version":2,"created":1554928869000,"modified":1554928874000,"deprecated":false,"name":"Protein FAM3C","accession":"Q92520","gene":"FAM3C","description":"May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7650114742163374,"antibodyCount":157,"monoclonalCount":37,"pubmedCount":null,"jensenScore":60.816298,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.46229726197099,"pubTatorScore":1.1219827388719121,"self":"https://pharos.nih.gov/idg/api/v1/targets(10261)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(10261)/properties"},"_links":{"count":1119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10261)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10261)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10261)/publications"},"_namespace":null},{"id":10262,"version":2,"created":1554928875000,"modified":1554928878000,"deprecated":false,"name":"Sclerostin domain-containing protein 1","accession":"Q6X4U4","gene":"SOSTDC1","description":"May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.293545946042547,"antibodyCount":109,"monoclonalCount":2,"pubmedCount":null,"jensenScore":177.836555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.41194481277619,"pubTatorScore":1.2317932536609997,"self":"https://pharos.nih.gov/idg/api/v1/targets(10262)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10262)/properties"},"_links":{"count":749,"href":"https://pharos.nih.gov/idg/api/v1/targets(10262)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10262)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10262)/publications"},"_namespace":null},{"id":10263,"version":2,"created":1554928878000,"modified":1554928882000,"deprecated":false,"name":"U7 snRNA-associated Sm-like protein LSm11","accession":"P83369","gene":"LSM11","description":"Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8817649445470552,"antibodyCount":49,"monoclonalCount":16,"pubmedCount":null,"jensenScore":8.088419,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.82913104292389,"pubTatorScore":0.7667432016882166,"self":"https://pharos.nih.gov/idg/api/v1/targets(10263)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10263)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(10263)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10263)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10263)/publications"},"_namespace":null},{"id":10264,"version":2,"created":1554928883000,"modified":1554928886000,"deprecated":false,"name":"T-complex protein 1 subunit zeta-2","accession":"Q92526","gene":"CCT6B","description":"Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.44629548323395746,"antibodyCount":85,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.854663,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.882653857812546,"pubTatorScore":0.15248220442000499,"self":"https://pharos.nih.gov/idg/api/v1/targets(10264)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(10264)/properties"},"_links":{"count":957,"href":"https://pharos.nih.gov/idg/api/v1/targets(10264)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10264)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10264)/publications"},"_namespace":null},{"id":10265,"version":2,"created":1554928886000,"modified":1554928889000,"deprecated":false,"name":"Nck-associated protein 5","accession":"O14513","gene":"NCKAP5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6223415740069376,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.953373,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.618933635125806,"pubTatorScore":1.5358456908161169,"self":"https://pharos.nih.gov/idg/api/v1/targets(10265)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10265)/properties"},"_links":{"count":834,"href":"https://pharos.nih.gov/idg/api/v1/targets(10265)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10265)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10265)/publications"},"_namespace":null},{"id":10266,"version":2,"created":1554928890000,"modified":1554928891000,"deprecated":false,"name":"Suppressor of cytokine signaling 7","accession":"O14512","gene":"SOCS7","description":"Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6433554748877552,"antibodyCount":122,"monoclonalCount":3,"pubmedCount":null,"jensenScore":42.530906,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.79985689960315,"pubTatorScore":1.4538115193759344,"self":"https://pharos.nih.gov/idg/api/v1/targets(10266)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10266)/properties"},"_links":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(10266)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10266)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10266)/publications"},"_namespace":null},{"id":10267,"version":2,"created":1554928892000,"modified":1554928894000,"deprecated":false,"name":"Adhesion G protein-coupled receptor B1","accession":"O14514","gene":"ADGRB1","description":"Vasculostatin-40: Inhibits angiogenesis.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.5524766945267965,"antibodyCount":267,"monoclonalCount":4,"pubmedCount":null,"jensenScore":42.825591,"patentCount":3890,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.114018773023197,"pubTatorScore":1.5193939810863093,"self":"https://pharos.nih.gov/idg/api/v1/targets(10267)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(10267)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(10267)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10267)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10267)/publications"},"_namespace":null},{"id":10268,"version":2,"created":1554928895000,"modified":1554928901000,"deprecated":false,"name":"Carnitine O-palmitoyltransferase 1, muscle isoform","accession":"Q92523","gene":"CPT1B","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.3365704756876053,"antibodyCount":299,"monoclonalCount":5,"pubmedCount":null,"jensenScore":211.909871,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.98666453582873,"pubTatorScore":2.2646296383216447,"self":"https://pharos.nih.gov/idg/api/v1/targets(10268)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(10268)/properties"},"_links":{"count":1290,"href":"https://pharos.nih.gov/idg/api/v1/targets(10268)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10268)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10268)/publications"},"_namespace":null},{"id":10269,"version":3,"created":1554928902000,"modified":1555039246000,"deprecated":false,"name":"Tribbles homolog 2","accession":"Q92519","gene":"TRIB2","description":"Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.4913326752464922,"antibodyCount":157,"monoclonalCount":31,"pubmedCount":null,"jensenScore":35.25972,"patentCount":4903,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":39.29135329099066,"pubTatorScore":1.573859264637505,"self":"https://pharos.nih.gov/idg/api/v1/targets(10269)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":390,"href":"https://pharos.nih.gov/idg/api/v1/targets(10269)/properties"},"_links":{"count":982,"href":"https://pharos.nih.gov/idg/api/v1/targets(10269)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10269)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10269)/publications"},"_namespace":null},{"id":10270,"version":2,"created":1554928907000,"modified":1554928912000,"deprecated":false,"name":"Son of sevenless homolog 2","accession":"Q07890","gene":"SOS2","description":"Promotes the exchange of Ras-bound GDP by GTP.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6211778243917745,"antibodyCount":134,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.948431,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.32621003165666,"pubTatorScore":1.3365525668800045,"self":"https://pharos.nih.gov/idg/api/v1/targets(10270)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(10270)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(10270)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10270)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10270)/publications"},"_namespace":null},{"id":10271,"version":2,"created":1554928913000,"modified":1554928914000,"deprecated":false,"name":"Barrier-to-autointegration factor-like protein","accession":"Q9H503","gene":"BANF2","description":"May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.135565461189266,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":133.44933,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.14436550593509,"pubTatorScore":2.1013746923634686,"self":"https://pharos.nih.gov/idg/api/v1/targets(10271)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10271)/properties"},"_links":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10271)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10271)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10271)/publications"},"_namespace":null},{"id":10272,"version":3,"created":1554928914000,"modified":1555039248000,"deprecated":false,"name":"HEAT repeat-containing protein 3","accession":"Q7Z4Q2","gene":"HEATR3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9457147048311025,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.86971,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":37,"knowledgeAvailability":30.02944471899822,"pubTatorScore":0.4272007052853922,"self":"https://pharos.nih.gov/idg/api/v1/targets(10272)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(10272)/properties"},"_links":{"count":846,"href":"https://pharos.nih.gov/idg/api/v1/targets(10272)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10272)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10272)/publications"},"_namespace":null},{"id":10273,"version":2,"created":1554928918000,"modified":1554928923000,"deprecated":false,"name":"ESF1 homolog","accession":"Q9H501","gene":"ESF1","description":"May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.1808901151559577,"antibodyCount":44,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.011904,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.30132692238454,"pubTatorScore":0.7403626894942439,"self":"https://pharos.nih.gov/idg/api/v1/targets(10273)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(10273)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(10273)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10273)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10273)/publications"},"_namespace":null},{"id":10274,"version":2,"created":1554928924000,"modified":1554928928000,"deprecated":false,"name":"Homeobox protein cut-like 2","accession":"O14529","gene":"CUX2","description":"May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7077246517142457,"antibodyCount":55,"monoclonalCount":5,"pubmedCount":null,"jensenScore":52.959474,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.84238401281159,"pubTatorScore":1.7391605821170857,"self":"https://pharos.nih.gov/idg/api/v1/targets(10274)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10274)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(10274)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10274)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10274)/publications"},"_namespace":null},{"id":10275,"version":3,"created":1554928930000,"modified":1555039250000,"deprecated":false,"name":"Son of sevenless homolog 1","accession":"Q07889","gene":"SOS1","description":"Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.69482066243596,"antibodyCount":147,"monoclonalCount":68,"pubmedCount":null,"jensenScore":466.169396,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":60.116457807668056,"pubTatorScore":2.4426380820927616,"self":"https://pharos.nih.gov/idg/api/v1/targets(10275)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":765,"href":"https://pharos.nih.gov/idg/api/v1/targets(10275)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10275)/links"},"_synonyms":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(10275)/synonyms"},"_publications":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(10275)/publications"},"_namespace":null},{"id":10276,"version":2,"created":1554928937000,"modified":1554928940000,"deprecated":false,"name":"Aquaporin-7","accession":"O14520","gene":"AQP7","description":"Forms a channel for water and glycerol.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0396072407490777,"antibodyCount":101,"monoclonalCount":2,"pubmedCount":null,"jensenScore":165.706518,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.397180563572306,"pubTatorScore":1.7856880584945682,"self":"https://pharos.nih.gov/idg/api/v1/targets(10276)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(10276)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(10276)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10276)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10276)/publications"},"_namespace":null},{"id":10277,"version":2,"created":1554928941000,"modified":1554928945000,"deprecated":false,"name":"Receptor-type tyrosine-protein phosphatase T","accession":"O14522","gene":"PTPRT","description":"May be involved in both signal transduction and cellular adhesion in the CNS.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.354504142639819,"antibodyCount":83,"monoclonalCount":11,"pubmedCount":null,"jensenScore":23.118987,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.1940487030793,"pubTatorScore":1.5031843443045945,"self":"https://pharos.nih.gov/idg/api/v1/targets(10277)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(10277)/properties"},"_links":{"count":839,"href":"https://pharos.nih.gov/idg/api/v1/targets(10277)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10277)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(10277)/publications"},"_namespace":null},{"id":10278,"version":3,"created":1554928945000,"modified":1555039252000,"deprecated":false,"name":"PWWP domain-containing protein MUM1","accession":"Q2TAK8","gene":"MUM1","description":"Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.","idgFamily":"Epigenetic","idgTDL":"Tdark","novelty":-0.619788758288394,"antibodyCount":146,"monoclonalCount":40,"pubmedCount":null,"jensenScore":4.695707,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":32.69905104400407,"pubTatorScore":2.095309084565401,"self":"https://pharos.nih.gov/idg/api/v1/targets(10278)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(10278)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(10278)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10278)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10278)/publications"},"_namespace":null},{"id":10279,"version":3,"created":1554928950000,"modified":1555039253000,"deprecated":false,"name":"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial","accession":"O14521","gene":"SDHD","description":"Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.6453538299316284,"antibodyCount":112,"monoclonalCount":8,"pubmedCount":null,"jensenScore":348.176612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":44.3671338933229,"pubTatorScore":2.3973127491060726,"self":"https://pharos.nih.gov/idg/api/v1/targets(10279)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(10279)/properties"},"_links":{"count":1434,"href":"https://pharos.nih.gov/idg/api/v1/targets(10279)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10279)/synonyms"},"_publications":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10279)/publications"},"_namespace":null},{"id":10280,"version":3,"created":1554928960000,"modified":1555039259000,"deprecated":false,"name":"Nuclear envelope integral membrane protein 1","accession":"O14524","gene":"NEMP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.09691001300805639,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.957143,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10280)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(10280)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(10280)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10280)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10280)/publications"},"_namespace":null},{"id":10281,"version":2,"created":1554928964000,"modified":1554928967000,"deprecated":false,"name":"Phospholipid transfer protein C2CD2L","accession":"O14523","gene":"C2CD2L","description":"Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.13376633948569214,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.696511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.4802486714896,"pubTatorScore":0.2041199826559248,"self":"https://pharos.nih.gov/idg/api/v1/targets(10281)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(10281)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(10281)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10281)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10281)/publications"},"_namespace":null},{"id":10282,"version":3,"created":1554928968000,"modified":1555039260000,"deprecated":false,"name":"F-BAR domain only protein 1","accession":"O14526","gene":"FCHO1","description":"Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8672861402044316,"antibodyCount":69,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.188828,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":31.528624437353947,"pubTatorScore":0.4374486708028546,"self":"https://pharos.nih.gov/idg/api/v1/targets(10282)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10282)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(10282)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10282)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10282)/publications"},"_namespace":null},{"id":10283,"version":2,"created":1554928972000,"modified":1554928975000,"deprecated":false,"name":"Astrotactin-1","accession":"O14525","gene":"ASTN1","description":"Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.375172232697446,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":23.936038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.99291393174005,"pubTatorScore":0.8850354901460479,"self":"https://pharos.nih.gov/idg/api/v1/targets(10283)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(10283)/properties"},"_links":{"count":783,"href":"https://pharos.nih.gov/idg/api/v1/targets(10283)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10283)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10283)/publications"},"_namespace":null},{"id":10284,"version":3,"created":1554928976000,"modified":1555039261000,"deprecated":false,"name":"Piezo-type mechanosensitive ion channel component 1","accession":"Q92508","gene":"PIEZO1","description":"Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.134436497047256,"antibodyCount":83,"monoclonalCount":0,"pubmedCount":null,"jensenScore":126.785914,"patentCount":1551,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.081707692081814,"pubTatorScore":1.6959059919958244,"self":"https://pharos.nih.gov/idg/api/v1/targets(10284)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(10284)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(10284)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10284)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10284)/publications"},"_namespace":null},{"id":10285,"version":3,"created":1554928981000,"modified":1555039263000,"deprecated":false,"name":"Estradiol 17-beta-dehydrogenase 8","accession":"Q92506","gene":"HSD17B8","description":"NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.575325437315688,"antibodyCount":140,"monoclonalCount":42,"pubmedCount":null,"jensenScore":39.848757,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":32.312073848234455,"pubTatorScore":1.2619973591742464,"self":"https://pharos.nih.gov/idg/api/v1/targets(10285)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(10285)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(10285)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10285)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10285)/publications"},"_namespace":null},{"id":10286,"version":2,"created":1554928986000,"modified":1554928988000,"deprecated":false,"name":"Uncharacterized protein C12orf54","accession":"Q6X4T0","gene":"C12orf54","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":34,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10286)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10286)/properties"},"_links":{"count":664,"href":"https://pharos.nih.gov/idg/api/v1/targets(10286)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10286)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10286)/publications"},"_namespace":null},{"id":10287,"version":2,"created":1554928988000,"modified":1554928988000,"deprecated":false,"name":"Putative uncharacterized protein C1orf137","accession":"Q5JT78","gene":"C1orf137","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10287)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10287)/properties"},"_links":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10287)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10287)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10287)/publications"},"_namespace":null},{"id":10288,"version":2,"created":1554928988000,"modified":1554928994000,"deprecated":false,"name":"Metalloreductase STEAP4","accession":"Q687X5","gene":"STEAP4","description":"Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.590299632998911,"antibodyCount":200,"monoclonalCount":20,"pubmedCount":null,"jensenScore":51.168722,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.079018396605647,"pubTatorScore":1.6642426547210154,"self":"https://pharos.nih.gov/idg/api/v1/targets(10288)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10288)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(10288)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10288)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10288)/publications"},"_namespace":null},{"id":10289,"version":2,"created":1554928995000,"modified":1554928998000,"deprecated":false,"name":"Growth/differentiation factor 7","accession":"Q7Z4P5","gene":"GDF7","description":"May play an active role in the motor area of the primate neocortex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5672471089900255,"antibodyCount":180,"monoclonalCount":104,"pubmedCount":null,"jensenScore":39.960516,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.239921135392915,"pubTatorScore":1.2757863764063921,"self":"https://pharos.nih.gov/idg/api/v1/targets(10289)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":264,"href":"https://pharos.nih.gov/idg/api/v1/targets(10289)/properties"},"_links":{"count":724,"href":"https://pharos.nih.gov/idg/api/v1/targets(10289)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10289)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10289)/publications"},"_namespace":null},{"id":10290,"version":3,"created":1554928999000,"modified":1555039264000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 U","accession":"Q5VVX9","gene":"UBE2U","description":"Catalyzes the covalent attachment of ubiquitin to other proteins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":110,"monoclonalCount":8,"pubmedCount":null,"jensenScore":0.375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":17.230012079273976,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10290)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10290)/properties"},"_links":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(10290)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10290)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10290)/publications"},"_namespace":null},{"id":10291,"version":2,"created":1554929001000,"modified":1554929004000,"deprecated":false,"name":"Early growth response protein 4","accession":"Q05215","gene":"EGR4","description":"Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4523872317508302,"antibodyCount":78,"monoclonalCount":0,"pubmedCount":null,"jensenScore":27.640904,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.22410041906988,"pubTatorScore":1.2833090549815078,"self":"https://pharos.nih.gov/idg/api/v1/targets(10291)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10291)/properties"},"_links":{"count":719,"href":"https://pharos.nih.gov/idg/api/v1/targets(10291)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10291)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10291)/publications"},"_namespace":null},{"id":10292,"version":2,"created":1554929005000,"modified":1554929010000,"deprecated":false,"name":"GA-binding protein alpha chain","accession":"Q06546","gene":"GABPA","description":"Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5028253351250467,"antibodyCount":289,"monoclonalCount":133,"pubmedCount":null,"jensenScore":31.693977,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.14459686494431,"pubTatorScore":1.7874825216656027,"self":"https://pharos.nih.gov/idg/api/v1/targets(10292)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(10292)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(10292)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10292)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10292)/publications"},"_namespace":null},{"id":10293,"version":2,"created":1554929011000,"modified":1554929013000,"deprecated":false,"name":"Alpha N-terminal protein methyltransferase 1B","accession":"Q5VVY1","gene":"METTL11B","description":"Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.12493873660829995,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.924242,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.286270663529955,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10293)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10293)/properties"},"_links":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10293)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(10293)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10293)/publications"},"_namespace":null},{"id":10294,"version":3,"created":1554929013000,"modified":1555039264000,"deprecated":false,"name":"GA-binding protein subunit beta-1","accession":"Q06547","gene":"GABPB1","description":"Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.641237924621151,"antibodyCount":211,"monoclonalCount":17,"pubmedCount":null,"jensenScore":36.696433,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.24270063425319,"pubTatorScore":1.5785527664506702,"self":"https://pharos.nih.gov/idg/api/v1/targets(10294)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(10294)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(10294)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10294)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10294)/publications"},"_namespace":null},{"id":10295,"version":3,"created":1554929019000,"modified":1555039266000,"deprecated":false,"name":"Dihydropyrimidinase-related protein 4","accession":"O14531","gene":"DPYSL4","description":"Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2496932170327604,"antibodyCount":150,"monoclonalCount":28,"pubmedCount":null,"jensenScore":17.359439,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":29.495753852763123,"pubTatorScore":1.0124537378575038,"self":"https://pharos.nih.gov/idg/api/v1/targets(10295)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(10295)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(10295)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10295)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10295)/publications"},"_namespace":null},{"id":10296,"version":3,"created":1554929023000,"modified":1555039267000,"deprecated":false,"name":"Thioredoxin domain-containing protein 9","accession":"O14530","gene":"TXNDC9","description":"Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.321960792747801,"antibodyCount":91,"monoclonalCount":8,"pubmedCount":null,"jensenScore":166.639495,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":33.57376589480933,"pubTatorScore":0.9366573274597908,"self":"https://pharos.nih.gov/idg/api/v1/targets(10296)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(10296)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(10296)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10296)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10296)/publications"},"_namespace":null},{"id":10297,"version":2,"created":1554929027000,"modified":1554929031000,"deprecated":false,"name":"Zinc transporter SLC39A7","accession":"Q92504","gene":"SLC39A7","description":"Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.4809940069569145,"antibodyCount":181,"monoclonalCount":1,"pubmedCount":null,"jensenScore":31.236964,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.5338609732304,"pubTatorScore":1.257023327893493,"self":"https://pharos.nih.gov/idg/api/v1/targets(10297)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":410,"href":"https://pharos.nih.gov/idg/api/v1/targets(10297)/properties"},"_links":{"count":1046,"href":"https://pharos.nih.gov/idg/api/v1/targets(10297)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10297)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10297)/publications"},"_namespace":null},{"id":10298,"version":2,"created":1554929032000,"modified":1554929037000,"deprecated":false,"name":"SEC14-like protein 1","accession":"Q92503","gene":"SEC14L1","description":"May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6321072836408154,"antibodyCount":26,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.217285,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.113637406170696,"pubTatorScore":0.7901342961663053,"self":"https://pharos.nih.gov/idg/api/v1/targets(10298)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(10298)/properties"},"_links":{"count":1111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10298)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10298)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10298)/publications"},"_namespace":null},{"id":10299,"version":3,"created":1554929038000,"modified":1555039268000,"deprecated":false,"name":"EH domain-containing protein 1","accession":"Q9H4M9","gene":"EHD1","description":"ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.696644082493936,"antibodyCount":113,"monoclonalCount":9,"pubmedCount":null,"jensenScore":478.029189,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.87917307614622,"pubTatorScore":1.9537058387772173,"self":"https://pharos.nih.gov/idg/api/v1/targets(10299)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":421,"href":"https://pharos.nih.gov/idg/api/v1/targets(10299)/properties"},"_links":{"count":1079,"href":"https://pharos.nih.gov/idg/api/v1/targets(10299)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10299)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10299)/publications"},"_namespace":null},{"id":10300,"version":2,"created":1554929043000,"modified":1554929046000,"deprecated":false,"name":"StAR-related lipid transfer protein 8","accession":"Q92502","gene":"STARD8","description":"Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0855410112014705,"antibodyCount":88,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.417027,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.680174900692442,"pubTatorScore":0.6859935563816688,"self":"https://pharos.nih.gov/idg/api/v1/targets(10300)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(10300)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(10300)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10300)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10300)/publications"},"_namespace":null},{"id":10301,"version":2,"created":1554929047000,"modified":1554929050000,"deprecated":false,"name":"39S ribosomal protein L24, mitochondrial","accession":"Q96A35","gene":"MRPL24","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":142,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.04611640527122,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10301)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(10301)/properties"},"_links":{"count":1070,"href":"https://pharos.nih.gov/idg/api/v1/targets(10301)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(10301)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10301)/publications"},"_namespace":null},{"id":10302,"version":3,"created":1554929051000,"modified":1555039271000,"deprecated":false,"name":"RING finger protein 166","accession":"Q96A37","gene":"RNF166","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.17136548530376383,"antibodyCount":73,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.922215,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":28.076413988134593,"pubTatorScore":-0.26687579242035087,"self":"https://pharos.nih.gov/idg/api/v1/targets(10302)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10302)/properties"},"_links":{"count":804,"href":"https://pharos.nih.gov/idg/api/v1/targets(10302)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10302)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10302)/publications"},"_namespace":null},{"id":10303,"version":3,"created":1554929053000,"modified":1555039272000,"deprecated":false,"name":"COMM domain-containing protein 6","accession":"Q7Z4G1","gene":"COMMD6","description":"May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8762738980769821,"antibodyCount":12,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.144143,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":27.11470874480454,"pubTatorScore":-0.0455490792240818,"self":"https://pharos.nih.gov/idg/api/v1/targets(10303)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10303)/properties"},"_links":{"count":869,"href":"https://pharos.nih.gov/idg/api/v1/targets(10303)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10303)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10303)/publications"},"_namespace":null},{"id":10304,"version":3,"created":1554929056000,"modified":1555039273000,"deprecated":false,"name":"tRNA (guanine(10)-N2)-methyltransferase homolog","accession":"Q7Z4G4","gene":"TRMT11","description":"Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6329069905763243,"antibodyCount":91,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.817511,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":29.06888606203624,"pubTatorScore":0.40369228041711436,"self":"https://pharos.nih.gov/idg/api/v1/targets(10304)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":232,"href":"https://pharos.nih.gov/idg/api/v1/targets(10304)/properties"},"_links":{"count":831,"href":"https://pharos.nih.gov/idg/api/v1/targets(10304)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10304)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10304)/publications"},"_namespace":null},{"id":10305,"version":2,"created":1554929059000,"modified":1554929061000,"deprecated":false,"name":"Killin","accession":"B2CW77","gene":"KLLN","description":"DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.100503862714803,"antibodyCount":106,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.083567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.876473620743877,"pubTatorScore":0.7468935307251721,"self":"https://pharos.nih.gov/idg/api/v1/targets(10305)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10305)/properties"},"_links":{"count":744,"href":"https://pharos.nih.gov/idg/api/v1/targets(10305)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10305)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10305)/publications"},"_namespace":null},{"id":10306,"version":2,"created":1554929062000,"modified":1554929065000,"deprecated":false,"name":"Coiled-coil domain-containing protein 47","accession":"Q96A33","gene":"CCDC47","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.12493873660829995,"antibodyCount":127,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.14765054453356,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10306)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(10306)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(10306)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10306)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10306)/publications"},"_namespace":null},{"id":10307,"version":2,"created":1554929066000,"modified":1554929069000,"deprecated":false,"name":"Coiled-coil domain-containing protein 30","accession":"Q5VVM6","gene":"CCDC30","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.17609125688420882,"antibodyCount":38,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.222222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.919553652035063,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10307)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(10307)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(10307)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10307)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10307)/publications"},"_namespace":null},{"id":10308,"version":2,"created":1554929070000,"modified":1554929072000,"deprecated":false,"name":"Myosin regulatory light chain 2, skeletal muscle isoform","accession":"Q96A32","gene":"MYLPF","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3471484866805867,"antibodyCount":119,"monoclonalCount":15,"pubmedCount":null,"jensenScore":20.160607,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.337304027490568,"pubTatorScore":0.5831483112342565,"self":"https://pharos.nih.gov/idg/api/v1/targets(10308)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(10308)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(10308)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10308)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10308)/publications"},"_namespace":null},{"id":10309,"version":3,"created":1554929073000,"modified":1555039274000,"deprecated":false,"name":"Splicing regulator RBM11","accession":"P57052","gene":"RBM11","description":"Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3010299956639812,"antibodyCount":91,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.136878,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":24.703249142667257,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10309)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(10309)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(10309)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10309)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10309)/publications"},"_namespace":null},{"id":10310,"version":2,"created":1554929076000,"modified":1554929079000,"deprecated":false,"name":"Histone H2B type F-S","accession":"P57053","gene":"H2BFS","description":"Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5021905111552238,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.037713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.456640761739806,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10310)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(10310)/properties"},"_links":{"count":674,"href":"https://pharos.nih.gov/idg/api/v1/targets(10310)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10310)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10310)/publications"},"_namespace":null},{"id":10311,"version":3,"created":1554929079000,"modified":1555039275000,"deprecated":false,"name":"Phosphatidylinositol N-acetylglucosaminyltransferase subunit P","accession":"P57054","gene":"PIGP","description":"Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8093700019608498,"antibodyCount":90,"monoclonalCount":8,"pubmedCount":null,"jensenScore":60.418863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.97360755112539,"pubTatorScore":1.1018452257762863,"self":"https://pharos.nih.gov/idg/api/v1/targets(10311)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(10311)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(10311)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10311)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10311)/publications"},"_namespace":null},{"id":10312,"version":2,"created":1554929083000,"modified":1554929086000,"deprecated":false,"name":"Protein ripply3","accession":"P57055","gene":"RIPPLY3","description":"Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.630088714928206,"antibodyCount":10,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.968316,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.473694459802978,"pubTatorScore":0.48902043106861287,"self":"https://pharos.nih.gov/idg/api/v1/targets(10312)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10312)/properties"},"_links":{"count":501,"href":"https://pharos.nih.gov/idg/api/v1/targets(10312)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10312)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10312)/publications"},"_namespace":null},{"id":10313,"version":3,"created":1554929087000,"modified":1555039276000,"deprecated":false,"name":"Nuclear RNA export factor 3","accession":"Q9H4D5","gene":"NXF3","description":"May function as a tissue-specific nuclear mRNA export factor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.001648667168054,"antibodyCount":126,"monoclonalCount":13,"pubmedCount":null,"jensenScore":9.815371,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":25.39382965211253,"pubTatorScore":0.8698600529620083,"self":"https://pharos.nih.gov/idg/api/v1/targets(10313)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(10313)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(10313)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10313)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10313)/publications"},"_namespace":null},{"id":10314,"version":2,"created":1554929091000,"modified":1554929096000,"deprecated":false,"name":"Calsyntenin-2","accession":"Q9H4D0","gene":"CLSTN2","description":"May modulate calcium-mediated postsynaptic signals.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8541580724808033,"antibodyCount":98,"monoclonalCount":2,"pubmedCount":null,"jensenScore":62.145559,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.69156584589159,"pubTatorScore":0.8850973964947444,"self":"https://pharos.nih.gov/idg/api/v1/targets(10314)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(10314)/properties"},"_links":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(10314)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10314)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10314)/publications"},"_namespace":null},{"id":10315,"version":3,"created":1554929097000,"modified":1555039277000,"deprecated":false,"name":"Copine-4","accession":"Q96A23","gene":"CPNE4","description":"Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3203351504645547,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.904545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":27.15154537642321,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(10315)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10315)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(10315)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10315)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10315)/publications"},"_namespace":null},{"id":10316,"version":2,"created":1554929102000,"modified":1554929105000,"deprecated":false,"name":"Low-density lipoprotein receptor-related protein 10","accession":"Q7Z4F1","gene":"LRP10","description":"Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5952862096691357,"antibodyCount":84,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.830303,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.71294356472896,"pubTatorScore":0.5599298346444258,"self":"https://pharos.nih.gov/idg/api/v1/targets(10316)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(10316)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(10316)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10316)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10316)/publications"},"_namespace":null},{"id":10317,"version":2,"created":1554929106000,"modified":1554929111000,"deprecated":false,"name":"Protein FAM162A","accession":"Q96A26","gene":"FAM162A","description":"Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1586268250795968,"antibodyCount":62,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.391984,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.67039386489534,"pubTatorScore":0.7720771271387445,"self":"https://pharos.nih.gov/idg/api/v1/targets(10317)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":319,"href":"https://pharos.nih.gov/idg/api/v1/targets(10317)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(10317)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10317)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10317)/publications"},"_namespace":null},{"id":10318,"version":3,"created":1554929112000,"modified":1555039281000,"deprecated":false,"name":"Transmembrane protein 106A","accession":"Q96A25","gene":"TMEM106A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.06455397804588937,"antibodyCount":34,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.257142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":44,"knowledgeAvailability":23.413493371031702,"pubTatorScore":-0.405765504109289,"self":"https://pharos.nih.gov/idg/api/v1/targets(10318)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(10318)/properties"},"_links":{"count":770,"href":"https://pharos.nih.gov/idg/api/v1/targets(10318)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10318)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10318)/publications"},"_namespace":null},{"id":10319,"version":2,"created":1554929116000,"modified":1554929118000,"deprecated":false,"name":"Uncharacterized protein C11orf52","accession":"Q96A22","gene":"C11orf52","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0,"antibodyCount":18,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.090909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-1.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10319)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10319)/properties"},"_links":{"count":763,"href":"https://pharos.nih.gov/idg/api/v1/targets(10319)/links"},"_synonyms":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10319)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10319)/publications"},"_namespace":null},{"id":10320,"version":2,"created":1554929118000,"modified":1554929123000,"deprecated":false,"name":"Glucose-6-phosphate exchanger SLC37A1","accession":"P57057","gene":"SLC37A1","description":"Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.6526760160505443,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.881288,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.105965257802097,"pubTatorScore":0.3424226808222063,"self":"https://pharos.nih.gov/idg/api/v1/targets(10320)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":318,"href":"https://pharos.nih.gov/idg/api/v1/targets(10320)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10320)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10320)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10320)/publications"},"_namespace":null},{"id":10321,"version":2,"created":1554929124000,"modified":1554929127000,"deprecated":false,"name":"Hormonally up-regulated neu tumor-associated kinase","accession":"P57058","gene":"HUNK","description":null,"idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.300240818320817,"antibodyCount":273,"monoclonalCount":61,"pubmedCount":null,"jensenScore":24.415769,"patentCount":9281,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.89551514425209,"pubTatorScore":1.169772300901034,"self":"https://pharos.nih.gov/idg/api/v1/targets(10321)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(10321)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(10321)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10321)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10321)/publications"},"_namespace":null},{"id":10322,"version":3,"created":1554929128000,"modified":1555039282000,"deprecated":false,"name":"Serine/threonine-protein kinase SIK1","accession":"P57059","gene":"SIK1","description":"Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.8933672110798843,"antibodyCount":246,"monoclonalCount":18,"pubmedCount":null,"jensenScore":752.357327,"patentCount":13099,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":36.41456146484385,"pubTatorScore":1.7728497722800574,"self":"https://pharos.nih.gov/idg/api/v1/targets(10322)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(10322)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(10322)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10322)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10322)/publications"},"_namespace":null},{"id":10323,"version":2,"created":1554929138000,"modified":1554929140000,"deprecated":false,"name":"SLAM family member 9","accession":"Q96A28","gene":"SLAMF9","description":"May play a role in the immune response.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.23775634598541995,"antibodyCount":120,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.811507,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.446078985207617,"pubTatorScore":0.4980832824898986,"self":"https://pharos.nih.gov/idg/api/v1/targets(10323)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10323)/properties"},"_links":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(10323)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10323)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10323)/publications"},"_namespace":null},{"id":10324,"version":2,"created":1554929141000,"modified":1554929141000,"deprecated":false,"name":"Putative uncharacterized protein PYCARD-AS1","accession":"I3L0S3","gene":"PYCARD-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.54062387353786,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10324)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10324)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10324)/links"},"_synonyms":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10324)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10324)/publications"},"_namespace":null},{"id":10325,"version":3,"created":1554929141000,"modified":1555039283000,"deprecated":false,"name":"GDP-fucose transporter 1","accession":"Q96A29","gene":"SLC35C1","description":"Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.0601130007863615,"antibodyCount":43,"monoclonalCount":1,"pubmedCount":null,"jensenScore":11.754437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.48324072542267,"pubTatorScore":1.0104211095964375,"self":"https://pharos.nih.gov/idg/api/v1/targets(10325)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(10325)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(10325)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10325)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10325)/publications"},"_namespace":null},{"id":10326,"version":3,"created":1554929145000,"modified":1555039284000,"deprecated":false,"name":"RWD domain-containing protein 2B","accession":"P57060","gene":"RWDD2B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":25.415246206567282,"pubTatorScore":0.17609125905568124,"self":"https://pharos.nih.gov/idg/api/v1/targets(10326)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(10326)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(10326)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10326)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10326)/publications"},"_namespace":null},{"id":10327,"version":3,"created":1554929150000,"modified":1555039286000,"deprecated":false,"name":"Long-chain fatty acid transport protein 3","accession":"Q5K4L6","gene":"SLC27A3","description":"Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-0.7550419298047257,"antibodyCount":101,"monoclonalCount":8,"pubmedCount":null,"jensenScore":5.628975,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":34.00450783028425,"pubTatorScore":0.8800501061728911,"self":"https://pharos.nih.gov/idg/api/v1/targets(10327)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10327)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(10327)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10327)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10327)/publications"},"_namespace":null},{"id":10328,"version":2,"created":1554929154000,"modified":1554929158000,"deprecated":false,"name":"Dedicator of cytokinesis protein 11","accession":"Q5JSL3","gene":"DOCK11","description":"Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.843208631996071,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":58.611344,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.075502174726637,"pubTatorScore":0.7032913781186614,"self":"https://pharos.nih.gov/idg/api/v1/targets(10328)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10328)/properties"},"_links":{"count":967,"href":"https://pharos.nih.gov/idg/api/v1/targets(10328)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10328)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10328)/publications"},"_namespace":null},{"id":10329,"version":2,"created":1554929159000,"modified":1554929164000,"deprecated":false,"name":"MHC class II transactivator","accession":"P33076","gene":"CIITA","description":"Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6395675361808215,"antibodyCount":146,"monoclonalCount":5,"pubmedCount":null,"jensenScore":506.827932,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.323927173367984,"pubTatorScore":2.59480235306097,"self":"https://pharos.nih.gov/idg/api/v1/targets(10329)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":530,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/properties"},"_links":{"count":1154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/synonyms"},"_publications":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(10329)/publications"},"_namespace":null},{"id":10330,"version":3,"created":1554929166000,"modified":1555039287000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 12","accession":"P58397","gene":"ADAMTS12","description":"Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.264684042698192,"antibodyCount":62,"monoclonalCount":2,"pubmedCount":null,"jensenScore":21.361984,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":30.79556935307699,"pubTatorScore":1.3550653685654812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10330)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10330)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(10330)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10330)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10330)/publications"},"_namespace":null},{"id":10331,"version":2,"created":1554929171000,"modified":1554929176000,"deprecated":false,"name":"Large proline-rich protein BAG6","accession":"P46379","gene":"BAG6","description":"Mediates ricin-induced apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.756069463195725,"antibodyCount":226,"monoclonalCount":8,"pubmedCount":null,"jensenScore":556.855356,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.20734003984629,"pubTatorScore":2.1222118958561107,"self":"https://pharos.nih.gov/idg/api/v1/targets(10331)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":560,"href":"https://pharos.nih.gov/idg/api/v1/targets(10331)/properties"},"_links":{"count":1316,"href":"https://pharos.nih.gov/idg/api/v1/targets(10331)/links"},"_synonyms":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(10331)/synonyms"},"_publications":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10331)/publications"},"_namespace":null},{"id":10332,"version":2,"created":1554929177000,"modified":1554929179000,"deprecated":false,"name":"FRAS1-related extracellular matrix protein 3","accession":"P0C091","gene":"FREM3","description":"Extracellular matrix protein which may play a role in cell adhesion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.701376068914491,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.977019,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.480726772320434,"pubTatorScore":0.37106786227173627,"self":"https://pharos.nih.gov/idg/api/v1/targets(10332)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10332)/properties"},"_links":{"count":588,"href":"https://pharos.nih.gov/idg/api/v1/targets(10332)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10332)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10332)/publications"},"_namespace":null},{"id":10333,"version":2,"created":1554929180000,"modified":1554929182000,"deprecated":false,"name":"Galactose-3-O-sulfotransferase 3","accession":"Q96A11","gene":"GAL3ST3","description":"Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7235302912795497,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.601593,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.048972032444947,"pubTatorScore":0.41774829137730035,"self":"https://pharos.nih.gov/idg/api/v1/targets(10333)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(10333)/properties"},"_links":{"count":705,"href":"https://pharos.nih.gov/idg/api/v1/targets(10333)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10333)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10333)/publications"},"_namespace":null},{"id":10334,"version":2,"created":1554929183000,"modified":1554929186000,"deprecated":false,"name":"Coiled-coil domain-containing protein 102A","accession":"Q96A19","gene":"CCDC102A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":86,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.93720538912425,"pubTatorScore":-0.2041199826559248,"self":"https://pharos.nih.gov/idg/api/v1/targets(10334)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":332,"href":"https://pharos.nih.gov/idg/api/v1/targets(10334)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(10334)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10334)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10334)/publications"},"_namespace":null},{"id":10335,"version":2,"created":1554929186000,"modified":1554929191000,"deprecated":false,"name":"PR domain zinc finger protein 15","accession":"P57071","gene":"PRDM15","description":"May be involved in transcriptional regulation.","idgFamily":"TF/Epigenetic","idgTDL":"Tdark","novelty":-0.3884364652952065,"antibodyCount":83,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.872849,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.71808407738544,"pubTatorScore":0.6103325090997167,"self":"https://pharos.nih.gov/idg/api/v1/targets(10335)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(10335)/properties"},"_links":{"count":895,"href":"https://pharos.nih.gov/idg/api/v1/targets(10335)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10335)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10335)/publications"},"_namespace":null},{"id":10336,"version":2,"created":1554929192000,"modified":1554929195000,"deprecated":false,"name":"Transcription factor SOX-8","accession":"P57073","gene":"SOX8","description":"May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3644862959415627,"antibodyCount":254,"monoclonalCount":45,"pubmedCount":null,"jensenScore":24.281581,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.26873700901747,"pubTatorScore":1.2474910299963258,"self":"https://pharos.nih.gov/idg/api/v1/targets(10336)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(10336)/properties"},"_links":{"count":813,"href":"https://pharos.nih.gov/idg/api/v1/targets(10336)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10336)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10336)/publications"},"_namespace":null},{"id":10337,"version":3,"created":1554929196000,"modified":1555039288000,"deprecated":false,"name":"Tubulin beta-1 chain","accession":"Q9H4B7","gene":"TUBB1","description":"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tclin","novelty":-1.3495319050393952,"antibodyCount":327,"monoclonalCount":165,"pubmedCount":null,"jensenScore":17.865314,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.496755359895428,"pubTatorScore":1.145460850407843,"self":"https://pharos.nih.gov/idg/api/v1/targets(10337)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":404,"href":"https://pharos.nih.gov/idg/api/v1/targets(10337)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(10337)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10337)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10337)/publications"},"_namespace":null},{"id":10338,"version":2,"created":1554929212000,"modified":1554929215000,"deprecated":false,"name":"Ubiquitin-associated and SH3 domain-containing protein A","accession":"P57075","gene":"UBASH3A","description":"Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3591579601541404,"antibodyCount":217,"monoclonalCount":27,"pubmedCount":null,"jensenScore":222.442891,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.49869351417961,"pubTatorScore":1.795427566533399,"self":"https://pharos.nih.gov/idg/api/v1/targets(10338)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10338)/publications"},"_namespace":null},{"id":10339,"version":3,"created":1554929216000,"modified":1555039290000,"deprecated":false,"name":"UPF0769 protein C21orf59","accession":"P57076","gene":"C21orf59","description":"Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.580639957066135,"antibodyCount":106,"monoclonalCount":44,"pubmedCount":null,"jensenScore":36.517155,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":0.0,"pubTatorScore":0.13830269816628146,"self":"https://pharos.nih.gov/idg/api/v1/targets(10339)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":304,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10339)/publications"},"_namespace":null},{"id":10340,"version":3,"created":1554929220000,"modified":1555039291000,"deprecated":false,"name":"Protein salvador homolog 1","accession":"Q9H4B6","gene":"SAV1","description":"Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8473264665930105,"antibodyCount":151,"monoclonalCount":41,"pubmedCount":null,"jensenScore":68.876297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.874947695132015,"pubTatorScore":1.5876085177936314,"self":"https://pharos.nih.gov/idg/api/v1/targets(10340)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10340)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(10340)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10340)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10340)/publications"},"_namespace":null},{"id":10341,"version":2,"created":1554929225000,"modified":1554929228000,"deprecated":false,"name":"MAP3K7 C-terminal-like protein","accession":"P57077","gene":"MAP3K7CL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5118833577216657,"antibodyCount":110,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.2,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.179993688693166,"pubTatorScore":0.692339388020864,"self":"https://pharos.nih.gov/idg/api/v1/targets(10341)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(10341)/properties"},"_links":{"count":805,"href":"https://pharos.nih.gov/idg/api/v1/targets(10341)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10341)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10341)/publications"},"_namespace":null},{"id":10342,"version":3,"created":1554929228000,"modified":1555039293000,"deprecated":false,"name":"5-hydroxytryptamine receptor 3E","accession":"A5X5Y0","gene":"HTR3E","description":"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.","idgFamily":"Ion Channel","idgTDL":"Tchem","novelty":-0.8315885294439107,"antibodyCount":83,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.495483,"patentCount":368,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":13.071005309667195,"pubTatorScore":1.0467884189344359,"self":"https://pharos.nih.gov/idg/api/v1/targets(10342)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10342)/properties"},"_links":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10342)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10342)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10342)/publications"},"_namespace":null},{"id":10343,"version":3,"created":1554929236000,"modified":1555039293000,"deprecated":false,"name":"Dipeptidase 3","accession":"Q9H4B8","gene":"DPEP3","description":"Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7386044120576325,"antibodyCount":89,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.035688,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":22.201879671940954,"pubTatorScore":-0.4357281747484515,"self":"https://pharos.nih.gov/idg/api/v1/targets(10343)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10343)/properties"},"_links":{"count":726,"href":"https://pharos.nih.gov/idg/api/v1/targets(10343)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10343)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10343)/publications"},"_namespace":null},{"id":10344,"version":2,"created":1554929239000,"modified":1554929244000,"deprecated":false,"name":"Receptor-interacting serine/threonine-protein kinase 4","accession":"P57078","gene":"RIPK4","description":"Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.9752242154257778,"antibodyCount":230,"monoclonalCount":72,"pubmedCount":null,"jensenScore":99.622689,"patentCount":14331,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.50350531899864,"pubTatorScore":1.4570454910941695,"self":"https://pharos.nih.gov/idg/api/v1/targets(10344)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":285,"href":"https://pharos.nih.gov/idg/api/v1/targets(10344)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(10344)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10344)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10344)/publications"},"_namespace":null},{"id":10345,"version":2,"created":1554929245000,"modified":1554929251000,"deprecated":false,"name":"Serine/threonine-protein kinase PLK3","accession":"Q9H4B4","gene":"PLK3","description":"Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.929212467769635,"antibodyCount":185,"monoclonalCount":3,"pubmedCount":null,"jensenScore":93.974942,"patentCount":21767,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.66548785983408,"pubTatorScore":2.061117268187657,"self":"https://pharos.nih.gov/idg/api/v1/targets(10345)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":439,"href":"https://pharos.nih.gov/idg/api/v1/targets(10345)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(10345)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10345)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10345)/publications"},"_namespace":null},{"id":10346,"version":2,"created":1554929252000,"modified":1554929256000,"deprecated":false,"name":"Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial","accession":"Q9H4B0","gene":"OSGEPL1","description":"Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.5300025644835094,"antibodyCount":43,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.563062,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.26576956364343,"pubTatorScore":-0.1790619817911351,"self":"https://pharos.nih.gov/idg/api/v1/targets(10346)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(10346)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(10346)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10346)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10346)/publications"},"_namespace":null},{"id":10347,"version":2,"created":1554929257000,"modified":1554929260000,"deprecated":false,"name":"TSSK6-activating co-chaperone protein","accession":"Q96A04","gene":"TSACC","description":"Co-chaperone that facilitates HSP-mediated activation of TSSK6.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":0.8450980400142568,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.043478,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.80832728590371,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(10347)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(10347)/properties"},"_links":{"count":756,"href":"https://pharos.nih.gov/idg/api/v1/targets(10347)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10347)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10347)/publications"},"_namespace":null},{"id":10348,"version":3,"created":1554929261000,"modified":1555039294000,"deprecated":false,"name":"Protein phosphatase 1 regulatory subunit 14A","accession":"Q96A00","gene":"PPP1R14A","description":"Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.5368448934286176,"antibodyCount":232,"monoclonalCount":57,"pubmedCount":null,"jensenScore":324.93065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.153490282108198,"pubTatorScore":1.7252760444058757,"self":"https://pharos.nih.gov/idg/api/v1/targets(10348)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(10348)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(10348)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10348)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10348)/publications"},"_namespace":null},{"id":10349,"version":2,"created":1554929266000,"modified":1554929270000,"deprecated":false,"name":"Putative nucleotidyltransferase FAM46B","accession":"Q96A09","gene":"FAM46B","description":"Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.34678748579036184,"antibodyCount":13,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.416667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.90880610160546,"pubTatorScore":-0.3467874862246563,"self":"https://pharos.nih.gov/idg/api/v1/targets(10349)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(10349)/properties"},"_links":{"count":762,"href":"https://pharos.nih.gov/idg/api/v1/targets(10349)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10349)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10349)/publications"},"_namespace":null},{"id":10350,"version":2,"created":1554929271000,"modified":1554929273000,"deprecated":false,"name":"V-type proton ATPase subunit E 2","accession":"Q96A05","gene":"ATP6V1E2","description":"Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7831187481092834,"antibodyCount":60,"monoclonalCount":3,"pubmedCount":null,"jensenScore":6.531494,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.28603045624921,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(10350)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(10350)/properties"},"_links":{"count":761,"href":"https://pharos.nih.gov/idg/api/v1/targets(10350)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10350)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10350)/publications"},"_namespace":null},{"id":10351,"version":3,"created":1554929274000,"modified":1555039298000,"deprecated":false,"name":"Histone H2B type 1-A","accession":"Q96A08","gene":"HIST1H2BA","description":"Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.624363816030507,"antibodyCount":119,"monoclonalCount":17,"pubmedCount":null,"jensenScore":45.489695,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":69,"knowledgeAvailability":19.667962967913528,"pubTatorScore":0.9777236052888477,"self":"https://pharos.nih.gov/idg/api/v1/targets(10351)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/properties"},"_links":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10351)/publications"},"_namespace":null},{"id":10352,"version":2,"created":1554929276000,"modified":1554929279000,"deprecated":false,"name":"T-box transcription factor TBX4","accession":"P57082","gene":"TBX4","description":"Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.6741136205525096,"antibodyCount":112,"monoclonalCount":1,"pubmedCount":null,"jensenScore":49.059494,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.24935653733662,"pubTatorScore":1.4326056293697718,"self":"https://pharos.nih.gov/idg/api/v1/targets(10352)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(10352)/properties"},"_links":{"count":716,"href":"https://pharos.nih.gov/idg/api/v1/targets(10352)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10352)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10352)/publications"},"_namespace":null},{"id":10353,"version":2,"created":1554929280000,"modified":1554929283000,"deprecated":false,"name":"Integrator complex subunit 6-like","accession":"Q5JSJ4","gene":"INTS6L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3864601912212653,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.316229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.6320238351265371,"self":"https://pharos.nih.gov/idg/api/v1/targets(10353)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10353)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(10353)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10353)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10353)/publications"},"_namespace":null},{"id":10354,"version":3,"created":1554929284000,"modified":1555039299000,"deprecated":false,"name":"Dipeptidase 2","accession":"Q9H4A9","gene":"DPEP2","description":"Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.89574354937478,"antibodyCount":34,"monoclonalCount":1,"pubmedCount":null,"jensenScore":6.833978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":27.781853888492176,"pubTatorScore":-0.09091970881126782,"self":"https://pharos.nih.gov/idg/api/v1/targets(10354)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(10354)/properties"},"_links":{"count":876,"href":"https://pharos.nih.gov/idg/api/v1/targets(10354)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10354)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10354)/publications"},"_namespace":null},{"id":10355,"version":2,"created":1554929288000,"modified":1554929290000,"deprecated":false,"name":"SCAN domain-containing protein 1","accession":"P57086","gene":"SCAND1","description":"May regulate transcriptional activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.272228481557324,"antibodyCount":154,"monoclonalCount":17,"pubmedCount":null,"jensenScore":18.572025,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.825235288207644,"pubTatorScore":1.0514448489929666,"self":"https://pharos.nih.gov/idg/api/v1/targets(10355)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10355)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(10355)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10355)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10355)/publications"},"_namespace":null},{"id":10356,"version":3,"created":1554929291000,"modified":1555039300000,"deprecated":false,"name":"Golgi phosphoprotein 3","accession":"Q9H4A6","gene":"GOLPH3","description":"Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.649616285841611,"antibodyCount":168,"monoclonalCount":18,"pubmedCount":null,"jensenScore":4208.30866,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":38.59653894690845,"pubTatorScore":2.8001163814873022,"self":"https://pharos.nih.gov/idg/api/v1/targets(10356)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":409,"href":"https://pharos.nih.gov/idg/api/v1/targets(10356)/properties"},"_links":{"count":1247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10356)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10356)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10356)/publications"},"_namespace":null},{"id":10357,"version":2,"created":1554929297000,"modified":1554929301000,"deprecated":false,"name":"Golgi phosphoprotein 3-like","accession":"Q9H4A5","gene":"GOLPH3L","description":"Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6205776645861332,"antibodyCount":103,"monoclonalCount":1,"pubmedCount":null,"jensenScore":3.497083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.382774998449754,"pubTatorScore":0.23888200539695909,"self":"https://pharos.nih.gov/idg/api/v1/targets(10357)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(10357)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(10357)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10357)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10357)/publications"},"_namespace":null},{"id":10358,"version":2,"created":1554929302000,"modified":1554929306000,"deprecated":false,"name":"Junctional adhesion molecule B","accession":"P57087","gene":"JAM2","description":"May play a role in the processes of lymphocyte homing to secondary lymphoid organs.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7293397935087755,"antibodyCount":302,"monoclonalCount":68,"pubmedCount":null,"jensenScore":50.599588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.869608188481706,"pubTatorScore":1.5775916186495809,"self":"https://pharos.nih.gov/idg/api/v1/targets(10358)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(10358)/properties"},"_links":{"count":944,"href":"https://pharos.nih.gov/idg/api/v1/targets(10358)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10358)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10358)/publications"},"_namespace":null},{"id":10359,"version":2,"created":1554929307000,"modified":1554929311000,"deprecated":false,"name":"Transmembrane protein 33","accession":"P57088","gene":"TMEM33","description":"Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5635811947741571,"antibodyCount":53,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.94506,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.990547134055042,"pubTatorScore":-0.03778840296416235,"self":"https://pharos.nih.gov/idg/api/v1/targets(10359)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(10359)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(10359)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10359)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10359)/publications"},"_namespace":null},{"id":10360,"version":2,"created":1554929312000,"modified":1554929318000,"deprecated":false,"name":"Aminopeptidase B","accession":"Q9H4A4","gene":"RNPEP","description":"Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.884020245433634,"antibodyCount":140,"monoclonalCount":32,"pubmedCount":null,"jensenScore":763.432747,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.68235479272793,"pubTatorScore":2.047858470681579,"self":"https://pharos.nih.gov/idg/api/v1/targets(10360)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(10360)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(10360)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10360)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10360)/publications"},"_namespace":null},{"id":10361,"version":2,"created":1554929319000,"modified":1554929326000,"deprecated":false,"name":"Serine/threonine-protein kinase WNK1","accession":"Q9H4A3","gene":"WNK1","description":"Isoform 3: Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.795570692709539,"antibodyCount":414,"monoclonalCount":28,"pubmedCount":null,"jensenScore":617.620956,"patentCount":82433,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":56.05565387664366,"pubTatorScore":2.5228551007765208,"self":"https://pharos.nih.gov/idg/api/v1/targets(10361)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":538,"href":"https://pharos.nih.gov/idg/api/v1/targets(10361)/properties"},"_links":{"count":1248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10361)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(10361)/synonyms"},"_publications":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(10361)/publications"},"_namespace":null},{"id":10362,"version":3,"created":1554929327000,"modified":1555039302000,"deprecated":false,"name":"tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4","accession":"P57081","gene":"WDR4","description":"Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9835797407638067,"antibodyCount":147,"monoclonalCount":31,"pubmedCount":null,"jensenScore":8.705436,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":35.21479465228328,"pubTatorScore":0.4286745716985777,"self":"https://pharos.nih.gov/idg/api/v1/targets(10362)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10362)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(10362)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10362)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10362)/publications"},"_namespace":null},{"id":10363,"version":2,"created":1554929332000,"modified":1554929336000,"deprecated":false,"name":"Zinc fingers and homeoboxes protein 3","accession":"Q9H4I2","gene":"ZHX3","description":"Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.45628747809937575,"antibodyCount":120,"monoclonalCount":10,"pubmedCount":null,"jensenScore":3.607625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.816973868280435,"pubTatorScore":0.4916949919932572,"self":"https://pharos.nih.gov/idg/api/v1/targets(10363)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(10363)/properties"},"_links":{"count":917,"href":"https://pharos.nih.gov/idg/api/v1/targets(10363)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10363)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10363)/publications"},"_namespace":null},{"id":10364,"version":2,"created":1554929337000,"modified":1554929342000,"deprecated":false,"name":"Ubiquitin thioesterase OTU1","accession":"Q5VVQ6","gene":"YOD1","description":"Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.6357318102189673,"antibodyCount":111,"monoclonalCount":0,"pubmedCount":null,"jensenScore":39.775816,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.40012878510232,"pubTatorScore":0.8487754190202758,"self":"https://pharos.nih.gov/idg/api/v1/targets(10364)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(10364)/properties"},"_links":{"count":868,"href":"https://pharos.nih.gov/idg/api/v1/targets(10364)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10364)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10364)/publications"},"_namespace":null},{"id":10365,"version":3,"created":1554929343000,"modified":1555039303000,"deprecated":false,"name":"TraB domain-containing protein","accession":"Q9H4I3","gene":"TRABD","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.051152521904513165,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.230769,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":27.50628830926253,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(10365)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10365)/properties"},"_links":{"count":929,"href":"https://pharos.nih.gov/idg/api/v1/targets(10365)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10365)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10365)/publications"},"_namespace":null},{"id":10366,"version":2,"created":1554929346000,"modified":1554929349000,"deprecated":false,"name":"Tripartite motif-containing protein 46","accession":"Q7Z4K8","gene":"TRIM46","description":"Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.513665317377241,"antibodyCount":78,"monoclonalCount":9,"pubmedCount":null,"jensenScore":30.50843,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.93190006165758,"pubTatorScore":0.5160663206190912,"self":"https://pharos.nih.gov/idg/api/v1/targets(10366)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10366)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(10366)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10366)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10366)/publications"},"_namespace":null},{"id":10367,"version":2,"created":1554929349000,"modified":1554929351000,"deprecated":false,"name":"Double-strand-break repair protein rad21-like protein 1","accession":"Q9H4I0","gene":"RAD21L1","description":"Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9860248977860536,"antibodyCount":6,"monoclonalCount":0,"pubmedCount":null,"jensenScore":12.072283,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.157015165560235,"pubTatorScore":0.6525643525055255,"self":"https://pharos.nih.gov/idg/api/v1/targets(10367)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(10367)/properties"},"_links":{"count":541,"href":"https://pharos.nih.gov/idg/api/v1/targets(10367)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10367)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10367)/publications"},"_namespace":null},{"id":10368,"version":3,"created":1554929352000,"modified":1555039304000,"deprecated":false,"name":"Neutrophil defensin 1","accession":"P59665","gene":"DEFA1B","description":"Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6039585275824735,"antibodyCount":259,"monoclonalCount":60,"pubmedCount":null,"jensenScore":37.377436,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":8.306769216473027,"pubTatorScore":0.5118833609788743,"self":"https://pharos.nih.gov/idg/api/v1/targets(10368)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(10368)/properties"},"_links":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(10368)/links"},"_synonyms":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10368)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10368)/publications"},"_namespace":null},{"id":10369,"version":3,"created":1554929353000,"modified":1555039305000,"deprecated":false,"name":"Anthrax toxin receptor 2","accession":"P58335","gene":"ANTXR2","description":"Necessary for cellular interactions with laminin and the extracellular matrix.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5279284332490284,"antibodyCount":126,"monoclonalCount":3,"pubmedCount":null,"jensenScore":346.446689,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":38.70269113592198,"pubTatorScore":1.8260207847756318,"self":"https://pharos.nih.gov/idg/api/v1/targets(10369)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(10369)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(10369)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10369)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10369)/publications"},"_namespace":null},{"id":10370,"version":3,"created":1554929359000,"modified":1555039307000,"deprecated":false,"name":"Neutrophil defensin 3","accession":"P59666","gene":"DEFA3","description":"Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9644810104621988,"antibodyCount":85,"monoclonalCount":4,"pubmedCount":null,"jensenScore":93.119699,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":16.622386401932307,"pubTatorScore":1.9204641189332374,"self":"https://pharos.nih.gov/idg/api/v1/targets(10370)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(10370)/properties"},"_links":{"count":768,"href":"https://pharos.nih.gov/idg/api/v1/targets(10370)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10370)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10370)/publications"},"_namespace":null},{"id":10371,"version":2,"created":1554929363000,"modified":1554929365000,"deprecated":false,"name":"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6","accession":"Q5VW22","gene":"AGAP6","description":"Putative GTPase-activating protein.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.23408320494763177,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.425326318464965,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10371)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":197,"href":"https://pharos.nih.gov/idg/api/v1/targets(10371)/properties"},"_links":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(10371)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10371)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10371)/publications"},"_namespace":null},{"id":10372,"version":3,"created":1554929366000,"modified":1555039309000,"deprecated":false,"name":"Myeloid leukemia factor 1","accession":"P58340","gene":"MLF1","description":"Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.550500619419095,"antibodyCount":346,"monoclonalCount":127,"pubmedCount":null,"jensenScore":36.276097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":31,"knowledgeAvailability":37.115561040425256,"pubTatorScore":1.4187036891944782,"self":"https://pharos.nih.gov/idg/api/v1/targets(10372)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(10372)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(10372)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10372)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10372)/publications"},"_namespace":null},{"id":10373,"version":2,"created":1554929371000,"modified":1554929375000,"deprecated":false,"name":"14-3-3 protein gamma","accession":"P61981","gene":"YWHAG","description":"Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8744270053776277,"antibodyCount":387,"monoclonalCount":151,"pubmedCount":null,"jensenScore":78.897526,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.16597919601527,"pubTatorScore":1.5950987266593395,"self":"https://pharos.nih.gov/idg/api/v1/targets(10373)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":630,"href":"https://pharos.nih.gov/idg/api/v1/targets(10373)/properties"},"_links":{"count":1102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10373)/links"},"_synonyms":{"count":144,"href":"https://pharos.nih.gov/idg/api/v1/targets(10373)/synonyms"},"_publications":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(10373)/publications"},"_namespace":null},{"id":10374,"version":3,"created":1554929377000,"modified":1555039314000,"deprecated":false,"name":"Hereditary hemochromatosis protein","accession":"Q30201","gene":"HFE","description":"Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.328151702072669,"antibodyCount":248,"monoclonalCount":52,"pubmedCount":null,"jensenScore":2229.454202,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":91,"knowledgeAvailability":50.53332254055874,"pubTatorScore":3.325893595525991,"self":"https://pharos.nih.gov/idg/api/v1/targets(10374)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1329,"href":"https://pharos.nih.gov/idg/api/v1/targets(10374)/properties"},"_links":{"count":1604,"href":"https://pharos.nih.gov/idg/api/v1/targets(10374)/links"},"_synonyms":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(10374)/synonyms"},"_publications":{"count":904,"href":"https://pharos.nih.gov/idg/api/v1/targets(10374)/publications"},"_namespace":null},{"id":10375,"version":2,"created":1554929393000,"modified":1554929398000,"deprecated":false,"name":"Protein FAM83D","accession":"Q9H4H8","gene":"FAM83D","description":"Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6489560525188776,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":45.108684,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.46257051156054,"pubTatorScore":1.5185139398778875,"self":"https://pharos.nih.gov/idg/api/v1/targets(10375)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(10375)/properties"},"_links":{"count":833,"href":"https://pharos.nih.gov/idg/api/v1/targets(10375)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10375)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10375)/publications"},"_namespace":null},{"id":10376,"version":3,"created":1554929399000,"modified":1555039319000,"deprecated":false,"name":"Antizyme inhibitor 2","accession":"Q96A70","gene":"AZIN2","description":"Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.052437381386471,"antibodyCount":50,"monoclonalCount":4,"pubmedCount":null,"jensenScore":97.570489,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":11.793968605090752,"pubTatorScore":1.987719449339499,"self":"https://pharos.nih.gov/idg/api/v1/targets(10376)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(10376)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(10376)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(10376)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10376)/publications"},"_namespace":null},{"id":10377,"version":3,"created":1554929404000,"modified":1555039320000,"deprecated":false,"name":"Putative monooxygenase p33MONOX","accession":"Q96A73","gene":"KIAA1191","description":"Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":59,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.4,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.362845551025405,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10377)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(10377)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(10377)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10377)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10377)/publications"},"_namespace":null},{"id":10378,"version":3,"created":1554929407000,"modified":1555039321000,"deprecated":false,"name":"Protein mago nashi homolog 2","accession":"Q96A72","gene":"MAGOHB","description":"Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3600837121737972,"antibodyCount":40,"monoclonalCount":2,"pubmedCount":null,"jensenScore":20.868915,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.9588055031953,"pubTatorScore":1.0858509453308682,"self":"https://pharos.nih.gov/idg/api/v1/targets(10378)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(10378)/properties"},"_links":{"count":952,"href":"https://pharos.nih.gov/idg/api/v1/targets(10378)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10378)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10378)/publications"},"_namespace":null},{"id":10379,"version":2,"created":1554929411000,"modified":1554929413000,"deprecated":false,"name":"Isoamyl acetate-hydrolyzing esterase 1 homolog","accession":"Q2TAA2","gene":"IAH1","description":"Probable lipase.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7958800173440752,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.083334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.099564003372105,"pubTatorScore":0.47712125471966244,"self":"https://pharos.nih.gov/idg/api/v1/targets(10379)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10379)/properties"},"_links":{"count":853,"href":"https://pharos.nih.gov/idg/api/v1/targets(10379)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10379)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10379)/publications"},"_namespace":null},{"id":10380,"version":3,"created":1554929414000,"modified":1555039322000,"deprecated":false,"name":"Protein GPR107","accession":"Q5VW38","gene":"GPR107","description":"Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.4573771956553163,"antibodyCount":113,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.034219,"patentCount":956,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":32.54842956937121,"pubTatorScore":0.4244855296869718,"self":"https://pharos.nih.gov/idg/api/v1/targets(10380)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(10380)/properties"},"_links":{"count":1087,"href":"https://pharos.nih.gov/idg/api/v1/targets(10380)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10380)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10380)/publications"},"_namespace":null},{"id":10381,"version":2,"created":1554929418000,"modified":1554929420000,"deprecated":false,"name":"Glycosyltransferase 6 domain-containing protein 1","accession":"Q7Z4J2","gene":"GLT6D1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6690067896444654,"antibodyCount":41,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.539682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.514573671985758,"pubTatorScore":0.7269987007928563,"self":"https://pharos.nih.gov/idg/api/v1/targets(10381)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10381)/properties"},"_links":{"count":249,"href":"https://pharos.nih.gov/idg/api/v1/targets(10381)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10381)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10381)/publications"},"_namespace":null},{"id":10382,"version":2,"created":1554929420000,"modified":1554929424000,"deprecated":false,"name":"Focadhesin","accession":"Q5VW36","gene":"FOCAD","description":"Potential tumor suppressor in gliomas.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6174247343426207,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.124905,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.451051099533665,"pubTatorScore":0.7606856946750145,"self":"https://pharos.nih.gov/idg/api/v1/targets(10382)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(10382)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(10382)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10382)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10382)/publications"},"_namespace":null},{"id":10383,"version":2,"created":1554929425000,"modified":1554929430000,"deprecated":false,"name":"Exocyst complex component 4","accession":"Q96A65","gene":"EXOC4","description":"Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.614918055719544,"antibodyCount":121,"monoclonalCount":45,"pubmedCount":null,"jensenScore":39.093677,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.140140473522685,"pubTatorScore":1.372195728442961,"self":"https://pharos.nih.gov/idg/api/v1/targets(10383)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(10383)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10383)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10383)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10383)/publications"},"_namespace":null},{"id":10384,"version":2,"created":1554929432000,"modified":1554929435000,"deprecated":false,"name":"FYVE, RhoGEF and PH domain-containing protein 3","accession":"Q5JSP0","gene":"FGD3","description":"Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9293986554924025,"antibodyCount":116,"monoclonalCount":22,"pubmedCount":null,"jensenScore":8.841841,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.30368633907237,"pubTatorScore":0.4095708348796345,"self":"https://pharos.nih.gov/idg/api/v1/targets(10384)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(10384)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(10384)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10384)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10384)/publications"},"_namespace":null},{"id":10385,"version":3,"created":1554929436000,"modified":1555039324000,"deprecated":false,"name":"BRO1 domain-containing protein BROX","accession":"Q5VW32","gene":"BROX","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9239098169700518,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.365476,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":24.34303407966908,"pubTatorScore":1.2654355450382686,"self":"https://pharos.nih.gov/idg/api/v1/targets(10385)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(10385)/properties"},"_links":{"count":954,"href":"https://pharos.nih.gov/idg/api/v1/targets(10385)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10385)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10385)/publications"},"_namespace":null},{"id":10386,"version":3,"created":1554929440000,"modified":1555039326000,"deprecated":false,"name":"Myosin light polypeptide 6","accession":"P60660","gene":"MYL6","description":"Regulatory light chain of myosin. Does not bind calcium.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8679908386775068,"antibodyCount":257,"monoclonalCount":46,"pubmedCount":null,"jensenScore":68.90099,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":37.19874774226461,"pubTatorScore":1.3343826296062837,"self":"https://pharos.nih.gov/idg/api/v1/targets(10386)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(10386)/properties"},"_links":{"count":1090,"href":"https://pharos.nih.gov/idg/api/v1/targets(10386)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10386)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10386)/publications"},"_namespace":null},{"id":10387,"version":2,"created":1554929445000,"modified":1554929445000,"deprecated":false,"name":"Putative DPH3 homolog B","accession":"Q9H4G8","gene":"DPH3P1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.6759948821557415,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10387)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10387)/properties"},"_links":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10387)/links"},"_synonyms":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10387)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10387)/publications"},"_namespace":null},{"id":10388,"version":2,"created":1554929445000,"modified":1554929448000,"deprecated":false,"name":"Tripartite motif-containing protein 52","accession":"Q96A61","gene":"TRIM52","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.28254659033188007,"antibodyCount":32,"monoclonalCount":9,"pubmedCount":null,"jensenScore":2.480952,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.968745947436105,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(10388)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10388)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(10388)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10388)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10388)/publications"},"_namespace":null},{"id":10389,"version":2,"created":1554929449000,"modified":1554929454000,"deprecated":false,"name":"Golgi-associated plant pathogenesis-related protein 1","accession":"Q9H4G4","gene":"GLIPR2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8589094127686346,"antibodyCount":109,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.034085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.557592031984697,"pubTatorScore":1.0227293859323983,"self":"https://pharos.nih.gov/idg/api/v1/targets(10389)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(10389)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(10389)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10389)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10389)/publications"},"_namespace":null},{"id":10390,"version":2,"created":1554929455000,"modified":1554929458000,"deprecated":false,"name":"Transmembrane protein 230","accession":"Q96A57","gene":"TMEM230","description":"Involved in trafficking and recycling of synaptic vesicles.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2751018145827715,"antibodyCount":110,"monoclonalCount":49,"pubmedCount":null,"jensenScore":18.590109,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.131193547434613,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10390)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(10390)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(10390)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(10390)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10390)/publications"},"_namespace":null},{"id":10391,"version":3,"created":1554929459000,"modified":1555039329000,"deprecated":false,"name":"Band 4.1-like protein 1","accession":"Q9H4G0","gene":"EPB41L1","description":"May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.779443198465328,"antibodyCount":87,"monoclonalCount":11,"pubmedCount":null,"jensenScore":58.068312,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":42,"knowledgeAvailability":44.28800388620082,"pubTatorScore":1.2122424872324609,"self":"https://pharos.nih.gov/idg/api/v1/targets(10391)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":393,"href":"https://pharos.nih.gov/idg/api/v1/targets(10391)/properties"},"_links":{"count":1077,"href":"https://pharos.nih.gov/idg/api/v1/targets(10391)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10391)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(10391)/publications"},"_namespace":null},{"id":10392,"version":3,"created":1554929464000,"modified":1555039330000,"deprecated":false,"name":"Tumor protein p53-inducible nuclear protein 1","accession":"Q96A56","gene":"TP53INP1","description":"Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.408743900194735,"antibodyCount":270,"monoclonalCount":0,"pubmedCount":null,"jensenScore":223.811493,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":39.740848405041525,"pubTatorScore":1.956754466965519,"self":"https://pharos.nih.gov/idg/api/v1/targets(10392)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(10392)/properties"},"_links":{"count":937,"href":"https://pharos.nih.gov/idg/api/v1/targets(10392)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10392)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(10392)/publications"},"_namespace":null},{"id":10393,"version":2,"created":1554929470000,"modified":1554929473000,"deprecated":false,"name":"MARVEL domain-containing protein 3","accession":"Q96A59","gene":"MARVELD3","description":"As a component of tight junctions, plays a role in paracellular ion conductivity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7642717730889094,"antibodyCount":40,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.407863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.287992439577465,"pubTatorScore":0.9789698406970981,"self":"https://pharos.nih.gov/idg/api/v1/targets(10393)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(10393)/properties"},"_links":{"count":864,"href":"https://pharos.nih.gov/idg/api/v1/targets(10393)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10393)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10393)/publications"},"_namespace":null},{"id":10394,"version":3,"created":1554929473000,"modified":1555039332000,"deprecated":false,"name":"Cystatin-9-like","accession":"Q9H4G1","gene":"CST9L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.66477624012016,"antibodyCount":53,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.878989,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":42,"knowledgeAvailability":11.879903853410138,"pubTatorScore":0.6097468657094596,"self":"https://pharos.nih.gov/idg/api/v1/targets(10394)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10394)/properties"},"_links":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10394)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10394)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10394)/publications"},"_namespace":null},{"id":10395,"version":3,"created":1554929474000,"modified":1555039332000,"deprecated":false,"name":"Ras-related and estrogen-regulated growth inhibitor","accession":"Q96A58","gene":"RERG","description":"Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2289932893032953,"antibodyCount":100,"monoclonalCount":7,"pubmedCount":null,"jensenScore":18.224647,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.64003635019718,"pubTatorScore":0.9827186424895941,"self":"https://pharos.nih.gov/idg/api/v1/targets(10395)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(10395)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(10395)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10395)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10395)/publications"},"_namespace":null},{"id":10396,"version":3,"created":1554929478000,"modified":1555039334000,"deprecated":false,"name":"LIM and senescent cell antigen-like-containing domain protein 2","accession":"Q7Z4I7","gene":"LIMS2","description":"Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4327021140264694,"antibodyCount":125,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.849207,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.6749319906194,"pubTatorScore":0.8873358741069428,"self":"https://pharos.nih.gov/idg/api/v1/targets(10396)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":309,"href":"https://pharos.nih.gov/idg/api/v1/targets(10396)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(10396)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10396)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10396)/publications"},"_namespace":null},{"id":10397,"version":3,"created":1554929483000,"modified":1555039335000,"deprecated":false,"name":"Adiponectin receptor protein 1","accession":"Q96A54","gene":"ADIPOR1","description":"Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.373717131681685,"antibodyCount":302,"monoclonalCount":27,"pubmedCount":null,"jensenScore":202.913091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":34.462688360144035,"pubTatorScore":2.282997754430762,"self":"https://pharos.nih.gov/idg/api/v1/targets(10397)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(10397)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(10397)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10397)/synonyms"},"_publications":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10397)/publications"},"_namespace":null},{"id":10398,"version":3,"created":1554929489000,"modified":1555039337000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 12-like protein 2","accession":"Q5VW00","gene":"DCAF12L2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2466723327623292,"antibodyCount":70,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.385965,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":14.82003251392778,"pubTatorScore":-0.24667207787412132,"self":"https://pharos.nih.gov/idg/api/v1/targets(10398)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(10398)/properties"},"_links":{"count":689,"href":"https://pharos.nih.gov/idg/api/v1/targets(10398)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10398)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10398)/publications"},"_namespace":null},{"id":10399,"version":3,"created":1554929492000,"modified":1555039338000,"deprecated":false,"name":"Profilin-3","accession":"P60673","gene":"PFN3","description":"Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.8906580679929454,"antibodyCount":8,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.075234,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":15.873787294030192,"pubTatorScore":0.6766936096248666,"self":"https://pharos.nih.gov/idg/api/v1/targets(10399)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10399)/properties"},"_links":{"count":271,"href":"https://pharos.nih.gov/idg/api/v1/targets(10399)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10399)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10399)/publications"},"_namespace":null},{"id":10400,"version":3,"created":1554929493000,"modified":1555039338000,"deprecated":false,"name":"SPARC-related modular calcium-binding protein 1","accession":"Q9H4F8","gene":"SMOC1","description":"Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1448598816538125,"antibodyCount":97,"monoclonalCount":23,"pubmedCount":null,"jensenScore":16.301302,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":36.17855265997036,"pubTatorScore":2.0088856308057785,"self":"https://pharos.nih.gov/idg/api/v1/targets(10400)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(10400)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(10400)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10400)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10400)/publications"},"_namespace":null},{"id":10401,"version":2,"created":1554929499000,"modified":1554929502000,"deprecated":false,"name":"Coiled-coil domain-containing protein 57","accession":"Q2TAC2","gene":"CCDC57","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.11089565772454141,"antibodyCount":34,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.181818,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.200475832355338,"pubTatorScore":-0.17118419782496672,"self":"https://pharos.nih.gov/idg/api/v1/targets(10401)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(10401)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10401)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10401)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10401)/publications"},"_namespace":null},{"id":10402,"version":2,"created":1554929503000,"modified":1554929503000,"deprecated":false,"name":"Uncharacterized protein C11orf98","accession":"E9PRG8","gene":"C11orf98","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10402)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10402)/properties"},"_links":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10402)/links"},"_synonyms":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10402)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10402)/publications"},"_namespace":null},{"id":10403,"version":2,"created":1554929503000,"modified":1554929506000,"deprecated":false,"name":"Mitoferrin-2","accession":"Q96A46","gene":"SLC25A28","description":"Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.0619263060727133,"antibodyCount":111,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.775673,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.184656498448334,"pubTatorScore":0.9713273485557419,"self":"https://pharos.nih.gov/idg/api/v1/targets(10403)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(10403)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(10403)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10403)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10403)/publications"},"_namespace":null},{"id":10404,"version":3,"created":1554929507000,"modified":1555039339000,"deprecated":false,"name":"Fanconi anemia core complex-associated protein 20","accession":"Q6NZ36","gene":"FAAP20","description":"Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6764032624957377,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.255542,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":0.713210471469627,"self":"https://pharos.nih.gov/idg/api/v1/targets(10404)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":246,"href":"https://pharos.nih.gov/idg/api/v1/targets(10404)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(10404)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10404)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10404)/publications"},"_namespace":null},{"id":10405,"version":2,"created":1554929512000,"modified":1554929515000,"deprecated":false,"name":"Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase","accession":"Q9H4F1","gene":"ST6GALNAC4","description":"Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7923638825128088,"antibodyCount":74,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.021146,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.001779359227044,"pubTatorScore":0.8239087626590423,"self":"https://pharos.nih.gov/idg/api/v1/targets(10405)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(10405)/properties"},"_links":{"count":837,"href":"https://pharos.nih.gov/idg/api/v1/targets(10405)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10405)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10405)/publications"},"_namespace":null},{"id":10406,"version":2,"created":1554929516000,"modified":1554929520000,"deprecated":false,"name":"HD domain-containing protein 2","accession":"Q7Z4H3","gene":"HDDC2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.929418921371348,"antibodyCount":39,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.358333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.82726704348052,"pubTatorScore":0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10406)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(10406)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(10406)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10406)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10406)/publications"},"_namespace":null},{"id":10407,"version":2,"created":1554929520000,"modified":1554929524000,"deprecated":false,"name":"GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase","accession":"Q2TAA5","gene":"ALG11","description":"Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.3187587626244128,"antibodyCount":162,"monoclonalCount":0,"pubmedCount":null,"jensenScore":20.297928,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.828514844997184,"pubTatorScore":0.9905924300371101,"self":"https://pharos.nih.gov/idg/api/v1/targets(10407)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(10407)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(10407)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10407)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10407)/publications"},"_namespace":null},{"id":10408,"version":2,"created":1554929524000,"modified":1554929527000,"deprecated":false,"name":"Insulin gene enhancer protein ISL-2","accession":"Q96A47","gene":"ISL2","description":"Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4666660146730384,"antibodyCount":188,"monoclonalCount":30,"pubmedCount":null,"jensenScore":28.194639,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.069341718722967,"pubTatorScore":1.1354355655405903,"self":"https://pharos.nih.gov/idg/api/v1/targets(10408)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10408)/properties"},"_links":{"count":623,"href":"https://pharos.nih.gov/idg/api/v1/targets(10408)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10408)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10408)/publications"},"_namespace":null},{"id":10409,"version":3,"created":1554929527000,"modified":1555039340000,"deprecated":false,"name":"Translin-associated factor X-interacting protein 1","accession":"Q2TAA8","gene":"TSNAXIP1","description":"Possible role in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":24,"monoclonalCount":8,"pubmedCount":null,"jensenScore":0.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":24.347772812688884,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10409)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(10409)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(10409)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10409)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10409)/publications"},"_namespace":null},{"id":10410,"version":2,"created":1554929530000,"modified":1554929533000,"deprecated":false,"name":"ADM2","accession":"Q7Z4H4","gene":"ADM2","description":"IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.498000556478421,"antibodyCount":139,"monoclonalCount":2,"pubmedCount":null,"jensenScore":325.535671,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.115776497294878,"pubTatorScore":2.2111398089757266,"self":"https://pharos.nih.gov/idg/api/v1/targets(10410)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(10410)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(10410)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10410)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(10410)/publications"},"_namespace":null},{"id":10411,"version":2,"created":1554929533000,"modified":1554929537000,"deprecated":false,"name":"HAUS augmin-like complex subunit 6","accession":"Q7Z4H7","gene":"HAUS6","description":"Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7397041731788595,"antibodyCount":70,"monoclonalCount":4,"pubmedCount":null,"jensenScore":5.753205,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.96845037472417,"pubTatorScore":0.852784807726932,"self":"https://pharos.nih.gov/idg/api/v1/targets(10411)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(10411)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(10411)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10411)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10411)/publications"},"_namespace":null},{"id":10412,"version":2,"created":1554929538000,"modified":1554929542000,"deprecated":false,"name":"SPRY domain-containing SOCS box protein 4","accession":"Q96A44","gene":"SPSB4","description":"Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.763428001380238,"antibodyCount":5,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.14429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.03319870625451,"pubTatorScore":0.13566270792554355,"self":"https://pharos.nih.gov/idg/api/v1/targets(10412)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(10412)/properties"},"_links":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(10412)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10412)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10412)/publications"},"_namespace":null},{"id":10413,"version":3,"created":1554929542000,"modified":1555039341000,"deprecated":false,"name":"Synapse-associated protein 1","accession":"Q96A49","gene":"SYAP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4486327210443629,"antibodyCount":100,"monoclonalCount":4,"pubmedCount":null,"jensenScore":3.120232,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.56807568688226,"pubTatorScore":0.33099319008845796,"self":"https://pharos.nih.gov/idg/api/v1/targets(10413)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(10413)/properties"},"_links":{"count":1057,"href":"https://pharos.nih.gov/idg/api/v1/targets(10413)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10413)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10413)/publications"},"_namespace":null},{"id":10414,"version":2,"created":1554929546000,"modified":1554929547000,"deprecated":false,"name":"Spermatogenesis-associated protein 31A6","accession":"Q5VVP1","gene":"SPATA31A6","description":"May play a role in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.311386178965,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10414)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10414)/properties"},"_links":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10414)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10414)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10414)/publications"},"_namespace":null},{"id":10415,"version":2,"created":1554929547000,"modified":1554929550000,"deprecated":false,"name":"Unconventional myosin-Ig","accession":"B0I1T2","gene":"MYO1G","description":"Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9846503055833515,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":98.263524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.571810548967058,"pubTatorScore":1.6028348193847757,"self":"https://pharos.nih.gov/idg/api/v1/targets(10415)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":284,"href":"https://pharos.nih.gov/idg/api/v1/targets(10415)/properties"},"_links":{"count":904,"href":"https://pharos.nih.gov/idg/api/v1/targets(10415)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10415)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10415)/publications"},"_namespace":null},{"id":10416,"version":2,"created":1554929551000,"modified":1554929555000,"deprecated":false,"name":"Protein FAM220A","accession":"Q7Z4H9","gene":"FAM220A","description":"May negatively regulate STAT3.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5509074688805811,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.245098,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.410031001994277,"pubTatorScore":-0.1760916933503803,"self":"https://pharos.nih.gov/idg/api/v1/targets(10416)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10416)/properties"},"_links":{"count":789,"href":"https://pharos.nih.gov/idg/api/v1/targets(10416)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10416)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10416)/publications"},"_namespace":null},{"id":10417,"version":3,"created":1554929555000,"modified":1555039342000,"deprecated":false,"name":"KDEL motif-containing protein 2","accession":"Q7Z4H8","gene":"KDELC2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.33881855619146894,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.491228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":27.100651791824152,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(10417)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(10417)/properties"},"_links":{"count":920,"href":"https://pharos.nih.gov/idg/api/v1/targets(10417)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10417)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10417)/publications"},"_namespace":null},{"id":10418,"version":3,"created":1554929560000,"modified":1555039344000,"deprecated":false,"name":"Rho-related GTP-binding protein RhoJ","accession":"Q9H4E5","gene":"RHOJ","description":"GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.682423431061847,"antibodyCount":232,"monoclonalCount":148,"pubmedCount":null,"jensenScore":485.117038,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":33.32195823479857,"pubTatorScore":1.7450183140051685,"self":"https://pharos.nih.gov/idg/api/v1/targets(10418)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10418)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(10418)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10418)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10418)/publications"},"_namespace":null},{"id":10419,"version":3,"created":1554929565000,"modified":1555039345000,"deprecated":false,"name":"Differentially expressed in FDCP 6 homolog","accession":"Q9H4E7","gene":"DEF6","description":"Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.13582129324016,"antibodyCount":280,"monoclonalCount":125,"pubmedCount":null,"jensenScore":137.700845,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":19,"knowledgeAvailability":33.334030578083016,"pubTatorScore":1.8546429782498348,"self":"https://pharos.nih.gov/idg/api/v1/targets(10419)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(10419)/properties"},"_links":{"count":940,"href":"https://pharos.nih.gov/idg/api/v1/targets(10419)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10419)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10419)/publications"},"_namespace":null},{"id":10420,"version":2,"created":1554929570000,"modified":1554929575000,"deprecated":false,"name":"Protein DEK","accession":"P35659","gene":"DEK","description":"Involved in chromatin organization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.249116098949535,"antibodyCount":183,"monoclonalCount":10,"pubmedCount":null,"jensenScore":193.233134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.35586953778777,"pubTatorScore":2.262116691917929,"self":"https://pharos.nih.gov/idg/api/v1/targets(10420)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":505,"href":"https://pharos.nih.gov/idg/api/v1/targets(10420)/properties"},"_links":{"count":1207,"href":"https://pharos.nih.gov/idg/api/v1/targets(10420)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10420)/synonyms"},"_publications":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10420)/publications"},"_namespace":null},{"id":10421,"version":3,"created":1554929577000,"modified":1555039346000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 73","accession":"Q5JTD7","gene":"LRRC73","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":58,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":15.857118197266978,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10421)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10421)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(10421)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10421)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10421)/publications"},"_namespace":null},{"id":10422,"version":3,"created":1554929580000,"modified":1555039348000,"deprecated":false,"name":"Pulmonary surfactant-associated protein C","accession":"P11686","gene":"SFTPC","description":"Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.756785787571848,"antibodyCount":288,"monoclonalCount":35,"pubmedCount":null,"jensenScore":510.442976,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":26.871420559781544,"pubTatorScore":2.6457198320381154,"self":"https://pharos.nih.gov/idg/api/v1/targets(10422)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10422)/properties"},"_links":{"count":928,"href":"https://pharos.nih.gov/idg/api/v1/targets(10422)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10422)/synonyms"},"_publications":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10422)/publications"},"_namespace":null},{"id":10423,"version":3,"created":1554929587000,"modified":1555039350000,"deprecated":false,"name":"Caveolae-associated protein 1","accession":"Q6NZI2","gene":"CAVIN1","description":"Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9737299249422848,"antibodyCount":169,"monoclonalCount":14,"pubmedCount":null,"jensenScore":101.799532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":0.0,"pubTatorScore":1.787130505018225,"self":"https://pharos.nih.gov/idg/api/v1/targets(10423)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(10423)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(10423)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10423)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10423)/publications"},"_namespace":null},{"id":10424,"version":2,"created":1554929592000,"modified":1554929596000,"deprecated":false,"name":"Nuclear pore complex protein Nup214","accession":"P35658","gene":"NUP214","description":"May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.250619302340115,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":166.638991,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.47701417551163,"pubTatorScore":1.837374388151427,"self":"https://pharos.nih.gov/idg/api/v1/targets(10424)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(10424)/properties"},"_links":{"count":1070,"href":"https://pharos.nih.gov/idg/api/v1/targets(10424)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10424)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10424)/publications"},"_namespace":null},{"id":10425,"version":3,"created":1554929598000,"modified":1555039351000,"deprecated":false,"name":"Uteroglobin","accession":"P11684","gene":"SCGB1A1","description":"Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.908836201057778,"antibodyCount":252,"monoclonalCount":87,"pubmedCount":null,"jensenScore":814.225783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.374104546634747,"pubTatorScore":2.6747791541775223,"self":"https://pharos.nih.gov/idg/api/v1/targets(10425)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(10425)/properties"},"_links":{"count":714,"href":"https://pharos.nih.gov/idg/api/v1/targets(10425)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10425)/synonyms"},"_publications":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(10425)/publications"},"_namespace":null},{"id":10426,"version":3,"created":1554929602000,"modified":1555039353000,"deprecated":false,"name":"Protein FAM19A1","accession":"Q7Z5A9","gene":"FAM19A1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.06214790530119616,"antibodyCount":37,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.885714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":18.18355918218585,"pubTatorScore":-0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10426)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(10426)/properties"},"_links":{"count":699,"href":"https://pharos.nih.gov/idg/api/v1/targets(10426)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10426)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10426)/publications"},"_namespace":null},{"id":10427,"version":3,"created":1554929606000,"modified":1555039357000,"deprecated":false,"name":"Protein FAM19A3","accession":"Q7Z5A8","gene":"FAM19A3","description":"Plays a role in the regulation of microglia polarization.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.020203388156355927,"antibodyCount":54,"monoclonalCount":17,"pubmedCount":null,"jensenScore":1.033333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":74,"knowledgeAvailability":15.851577501997504,"pubTatorScore":-0.2218487496163564,"self":"https://pharos.nih.gov/idg/api/v1/targets(10427)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(10427)/properties"},"_links":{"count":594,"href":"https://pharos.nih.gov/idg/api/v1/targets(10427)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10427)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10427)/publications"},"_namespace":null},{"id":10428,"version":3,"created":1554929608000,"modified":1555039357000,"deprecated":false,"name":"Transcription factor Sp1","accession":"P08047","gene":"SP1","description":"Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.0154096847728487,"antibodyCount":780,"monoclonalCount":177,"pubmedCount":null,"jensenScore":976.662959,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":56.6920889154442,"pubTatorScore":3.4580251091889807,"self":"https://pharos.nih.gov/idg/api/v1/targets(10428)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1390,"href":"https://pharos.nih.gov/idg/api/v1/targets(10428)/properties"},"_links":{"count":1807,"href":"https://pharos.nih.gov/idg/api/v1/targets(10428)/links"},"_synonyms":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(10428)/synonyms"},"_publications":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(10428)/publications"},"_namespace":null},{"id":10429,"version":2,"created":1554929627000,"modified":1554929631000,"deprecated":false,"name":"Transcription initiation factor TFIID subunit 3","accession":"Q5VWG9","gene":"TAF3","description":"Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.9763063073299847,"antibodyCount":103,"monoclonalCount":1,"pubmedCount":null,"jensenScore":8.71464,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.97255313049603,"pubTatorScore":1.140739898161708,"self":"https://pharos.nih.gov/idg/api/v1/targets(10429)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(10429)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(10429)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10429)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10429)/publications"},"_namespace":null},{"id":10430,"version":2,"created":1554929632000,"modified":1554929634000,"deprecated":false,"name":"Serine protease 42","accession":"Q7Z5A4","gene":"PRSS42","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.0,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.788889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.909580330161308,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10430)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(10430)/properties"},"_links":{"count":696,"href":"https://pharos.nih.gov/idg/api/v1/targets(10430)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10430)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10430)/publications"},"_namespace":null},{"id":10431,"version":3,"created":1554929635000,"modified":1555039363000,"deprecated":false,"name":"Mediator of RNA polymerase II transcription subunit 19","accession":"A0JLT2","gene":"MED19","description":"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8770809703133688,"antibodyCount":100,"monoclonalCount":14,"pubmedCount":null,"jensenScore":71.360967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":30,"knowledgeAvailability":30.83848307923623,"pubTatorScore":1.467402525405759,"self":"https://pharos.nih.gov/idg/api/v1/targets(10431)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":254,"href":"https://pharos.nih.gov/idg/api/v1/targets(10431)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(10431)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10431)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(10431)/publications"},"_namespace":null},{"id":10432,"version":3,"created":1554929639000,"modified":1555039364000,"deprecated":false,"name":"Protein FAM19A5","accession":"Q7Z5A7","gene":"FAM19A5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2174135640274582,"antibodyCount":9,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.94802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":26.228596536044403,"pubTatorScore":0.0910803519704297,"self":"https://pharos.nih.gov/idg/api/v1/targets(10432)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(10432)/properties"},"_links":{"count":825,"href":"https://pharos.nih.gov/idg/api/v1/targets(10432)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10432)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10432)/publications"},"_namespace":null},{"id":10433,"version":3,"created":1554929644000,"modified":1555039365000,"deprecated":false,"name":"Zinc finger Y-chromosomal protein","accession":"P08048","gene":"ZFY","description":"Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2316868163092036,"antibodyCount":88,"monoclonalCount":1,"pubmedCount":null,"jensenScore":159.031566,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":19.766897644652065,"pubTatorScore":2.0519254381935754,"self":"https://pharos.nih.gov/idg/api/v1/targets(10433)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(10433)/properties"},"_links":{"count":764,"href":"https://pharos.nih.gov/idg/api/v1/targets(10433)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10433)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10433)/publications"},"_namespace":null},{"id":10434,"version":3,"created":1554929648000,"modified":1555039367000,"deprecated":false,"name":"CD97 antigen","accession":"P48960","gene":"ADGRE5","description":"Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.8684849500172263,"antibodyCount":601,"monoclonalCount":307,"pubmedCount":null,"jensenScore":85.95079,"patentCount":15315,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":38,"knowledgeAvailability":39.63865442689684,"pubTatorScore":1.8263580518108762,"self":"https://pharos.nih.gov/idg/api/v1/targets(10434)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(10434)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(10434)/links"},"_synonyms":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10434)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10434)/publications"},"_namespace":null},{"id":10435,"version":3,"created":1554929654000,"modified":1555039369000,"deprecated":false,"name":"Visual system homeobox 2","accession":"P58304","gene":"VSX2","description":"Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.1457996595083433,"antibodyCount":160,"monoclonalCount":5,"pubmedCount":null,"jensenScore":129.919947,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":22.485927190605207,"pubTatorScore":1.7415896054685027,"self":"https://pharos.nih.gov/idg/api/v1/targets(10435)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(10435)/properties"},"_links":{"count":545,"href":"https://pharos.nih.gov/idg/api/v1/targets(10435)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10435)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10435)/publications"},"_namespace":null},{"id":10436,"version":3,"created":1554929657000,"modified":1555039371000,"deprecated":false,"name":"DNA dC->dU-editing enzyme APOBEC-3D","accession":"Q96AK3","gene":"APOBEC3D","description":"DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5701258440392967,"antibodyCount":110,"monoclonalCount":2,"pubmedCount":null,"jensenScore":28.928006,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":16.625612479295803,"pubTatorScore":1.8505346212485605,"self":"https://pharos.nih.gov/idg/api/v1/targets(10436)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(10436)/properties"},"_links":{"count":845,"href":"https://pharos.nih.gov/idg/api/v1/targets(10436)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(10436)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10436)/publications"},"_namespace":null},{"id":10437,"version":3,"created":1554929661000,"modified":1555039372000,"deprecated":false,"name":"Complement factor H-related protein 2","accession":"P36980","gene":"CFHR2","description":"Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0174308797965692,"antibodyCount":82,"monoclonalCount":7,"pubmedCount":null,"jensenScore":9.094956,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":16.67801319433345,"pubTatorScore":0.8849885169186958,"self":"https://pharos.nih.gov/idg/api/v1/targets(10437)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(10437)/properties"},"_links":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10437)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10437)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10437)/publications"},"_namespace":null},{"id":10438,"version":2,"created":1554929662000,"modified":1554929669000,"deprecated":false,"name":"Galectin-1","accession":"P09382","gene":"LGALS1","description":"Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.871245427309311,"antibodyCount":570,"monoclonalCount":162,"pubmedCount":null,"jensenScore":744.640874,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.45104472963181,"pubTatorScore":3.1867203924419343,"self":"https://pharos.nih.gov/idg/api/v1/targets(10438)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":726,"href":"https://pharos.nih.gov/idg/api/v1/targets(10438)/properties"},"_links":{"count":1386,"href":"https://pharos.nih.gov/idg/api/v1/targets(10438)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10438)/synonyms"},"_publications":{"count":356,"href":"https://pharos.nih.gov/idg/api/v1/targets(10438)/publications"},"_namespace":null},{"id":10439,"version":2,"created":1554929671000,"modified":1554929671000,"deprecated":false,"name":"Late cornified envelope protein 6A","accession":"A0A183","gene":"LCE6A","description":"Precursors of the cornified envelope of the stratum corneum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.146128035678238,"antibodyCount":9,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.546383891847864,"pubTatorScore":-1.3222197290286184,"self":"https://pharos.nih.gov/idg/api/v1/targets(10439)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10439)/properties"},"_links":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10439)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(10439)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10439)/publications"},"_namespace":null},{"id":10440,"version":3,"created":1554929671000,"modified":1555039372000,"deprecated":false,"name":"Vesicle transport through interaction with t-SNAREs homolog 1A","accession":"Q96AJ9","gene":"VTI1A","description":"V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1779582375912432,"antibodyCount":182,"monoclonalCount":31,"pubmedCount":null,"jensenScore":14.768111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.21496180122216,"pubTatorScore":1.0313233341901524,"self":"https://pharos.nih.gov/idg/api/v1/targets(10440)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":426,"href":"https://pharos.nih.gov/idg/api/v1/targets(10440)/properties"},"_links":{"count":1162,"href":"https://pharos.nih.gov/idg/api/v1/targets(10440)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10440)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(10440)/publications"},"_namespace":null},{"id":10441,"version":3,"created":1554929677000,"modified":1555039374000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11","accession":"P61952","gene":"GNG11","description":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7428485609160079,"antibodyCount":64,"monoclonalCount":8,"pubmedCount":null,"jensenScore":5.2793,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.118651955149527,"pubTatorScore":0.7237909099034882,"self":"https://pharos.nih.gov/idg/api/v1/targets(10441)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10441)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(10441)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10441)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10441)/publications"},"_namespace":null},{"id":10442,"version":2,"created":1554929682000,"modified":1554929686000,"deprecated":false,"name":"Inositol-trisphosphate 3-kinase A","accession":"P23677","gene":"ITPKA","description":null,"idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.4282434333516025,"antibodyCount":156,"monoclonalCount":0,"pubmedCount":null,"jensenScore":28.042018,"patentCount":625,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.20833561932984,"pubTatorScore":1.4616664045240864,"self":"https://pharos.nih.gov/idg/api/v1/targets(10442)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10442)/properties"},"_links":{"count":809,"href":"https://pharos.nih.gov/idg/api/v1/targets(10442)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10442)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10442)/publications"},"_namespace":null},{"id":10443,"version":3,"created":1554929686000,"modified":1555039375000,"deprecated":false,"name":"Small ubiquitin-related modifier 2","accession":"P61956","gene":"SUMO2","description":"Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.190331893602852,"antibodyCount":613,"monoclonalCount":193,"pubmedCount":null,"jensenScore":136.716219,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.97823870879296,"pubTatorScore":2.102158922364848,"self":"https://pharos.nih.gov/idg/api/v1/targets(10443)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(10443)/properties"},"_links":{"count":1202,"href":"https://pharos.nih.gov/idg/api/v1/targets(10443)/links"},"_synonyms":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10443)/synonyms"},"_publications":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(10443)/publications"},"_namespace":null},{"id":10444,"version":2,"created":1554929693000,"modified":1554929698000,"deprecated":false,"name":"Phospholipid hydroperoxide glutathione peroxidase, mitochondrial","accession":"P36969","gene":"GPX4","description":"Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.888905589490664,"antibodyCount":227,"monoclonalCount":46,"pubmedCount":null,"jensenScore":707.63467,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.390547835249535,"pubTatorScore":2.2991378561939166,"self":"https://pharos.nih.gov/idg/api/v1/targets(10444)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(10444)/properties"},"_links":{"count":1202,"href":"https://pharos.nih.gov/idg/api/v1/targets(10444)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10444)/synonyms"},"_publications":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10444)/publications"},"_namespace":null},{"id":10445,"version":2,"created":1554929699000,"modified":1554929707000,"deprecated":false,"name":"DNA damage-inducible transcript 3 protein","accession":"P35638","gene":"DDIT3","description":"Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-2.944338857632132,"antibodyCount":704,"monoclonalCount":153,"pubmedCount":null,"jensenScore":736.044032,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":49.069474332348584,"pubTatorScore":3.502858418427503,"self":"https://pharos.nih.gov/idg/api/v1/targets(10445)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":653,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/properties"},"_links":{"count":1262,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/synonyms"},"_publications":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(10445)/publications"},"_namespace":null},{"id":10446,"version":2,"created":1554929709000,"modified":1554929714000,"deprecated":false,"name":"LIM domain transcription factor LMO4","accession":"P61968","gene":"LMO4","description":"Probable transcriptional factor.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0835324700895483,"antibodyCount":216,"monoclonalCount":40,"pubmedCount":null,"jensenScore":14.532656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.04977429300067,"pubTatorScore":1.6982493290938172,"self":"https://pharos.nih.gov/idg/api/v1/targets(10446)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/properties"},"_links":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10446)/publications"},"_namespace":null},{"id":10447,"version":3,"created":1554929715000,"modified":1555039377000,"deprecated":false,"name":"RNA-binding protein FUS","accession":"P35637","gene":"FUS","description":"Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.179082971516985,"antibodyCount":267,"monoclonalCount":26,"pubmedCount":null,"jensenScore":1493.961898,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":51.85035011538609,"pubTatorScore":2.7972457840023743,"self":"https://pharos.nih.gov/idg/api/v1/targets(10447)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":738,"href":"https://pharos.nih.gov/idg/api/v1/targets(10447)/properties"},"_links":{"count":1472,"href":"https://pharos.nih.gov/idg/api/v1/targets(10447)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10447)/synonyms"},"_publications":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(10447)/publications"},"_namespace":null},{"id":10448,"version":3,"created":1554929725000,"modified":1555039380000,"deprecated":false,"name":"Placenta-specific protein 9","accession":"Q5JTB6","gene":"PLAC9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.23398265988810846,"antibodyCount":53,"monoclonalCount":6,"pubmedCount":null,"jensenScore":1.821821,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":19.570439350588543,"pubTatorScore":0.35485512928775537,"self":"https://pharos.nih.gov/idg/api/v1/targets(10448)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(10448)/properties"},"_links":{"count":802,"href":"https://pharos.nih.gov/idg/api/v1/targets(10448)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10448)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10448)/publications"},"_namespace":null},{"id":10449,"version":2,"created":1554929728000,"modified":1554929729000,"deprecated":false,"name":"FXYD domain-containing ion transport regulator 4","accession":"P59646","gene":"FXYD4","description":null,"idgFamily":"Ion Channel","idgTDL":"Tdark","novelty":-0.8169208035968791,"antibodyCount":14,"monoclonalCount":1,"pubmedCount":null,"jensenScore":5.293986,"patentCount":1598,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.493194711389243,"pubTatorScore":1.3219730006182528,"self":"https://pharos.nih.gov/idg/api/v1/targets(10449)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(10449)/properties"},"_links":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(10449)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10449)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10449)/publications"},"_namespace":null},{"id":10450,"version":2,"created":1554929730000,"modified":1554929733000,"deprecated":false,"name":"Zinc finger protein 121","accession":"P58317","gene":"ZNF121","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.2900346137511377,"antibodyCount":32,"monoclonalCount":10,"pubmedCount":null,"jensenScore":1.618182,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.82587790157286,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10450)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(10450)/properties"},"_links":{"count":786,"href":"https://pharos.nih.gov/idg/api/v1/targets(10450)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10450)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10450)/publications"},"_namespace":null},{"id":10451,"version":3,"created":1554929734000,"modified":1555039381000,"deprecated":false,"name":"Clusterin-associated protein 1","accession":"Q96AJ1","gene":"CLUAP1","description":"Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3578743418338133,"antibodyCount":96,"monoclonalCount":6,"pubmedCount":null,"jensenScore":19.574566,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.025564506225294,"pubTatorScore":1.0479235263891533,"self":"https://pharos.nih.gov/idg/api/v1/targets(10451)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(10451)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(10451)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10451)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10451)/publications"},"_namespace":null},{"id":10452,"version":3,"created":1554929739000,"modified":1555039383000,"deprecated":false,"name":"DDB1- and CUL4-associated factor 7","accession":"P61962","gene":"DCAF7","description":"Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7387742560485782,"antibodyCount":134,"monoclonalCount":4,"pubmedCount":null,"jensenScore":56.552477,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":29,"knowledgeAvailability":36.75065336237425,"pubTatorScore":2.4002439199775147,"self":"https://pharos.nih.gov/idg/api/v1/targets(10452)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(10452)/properties"},"_links":{"count":1072,"href":"https://pharos.nih.gov/idg/api/v1/targets(10452)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10452)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10452)/publications"},"_namespace":null},{"id":10453,"version":3,"created":1554929744000,"modified":1555039384000,"deprecated":false,"name":"UDP-glucuronosyltransferase 1-4","accession":"P22310","gene":"UGT1A4","description":"UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8074919247433998,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":62.885492,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":22.987256015041044,"pubTatorScore":2.2067053628250575,"self":"https://pharos.nih.gov/idg/api/v1/targets(10453)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10453)/properties"},"_links":{"count":262,"href":"https://pharos.nih.gov/idg/api/v1/targets(10453)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10453)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10453)/publications"},"_namespace":null},{"id":10454,"version":3,"created":1554929746000,"modified":1555039385000,"deprecated":false,"name":"Ubiquitin-fold modifier 1","accession":"P61960","gene":"UFM1","description":"Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.459189563305862,"antibodyCount":43,"monoclonalCount":6,"pubmedCount":null,"jensenScore":31.230319,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.2363009559943,"pubTatorScore":1.0928096694358376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10454)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(10454)/properties"},"_links":{"count":1056,"href":"https://pharos.nih.gov/idg/api/v1/targets(10454)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10454)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10454)/publications"},"_namespace":null},{"id":10455,"version":3,"created":1554929751000,"modified":1555039386000,"deprecated":false,"name":"AP-1 complex subunit sigma-1A","accession":"P61966","gene":"AP1S1","description":"Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.577088743632492,"antibodyCount":93,"monoclonalCount":2,"pubmedCount":null,"jensenScore":35.564875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":37.47309286360057,"pubTatorScore":1.1579313917245597,"self":"https://pharos.nih.gov/idg/api/v1/targets(10455)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(10455)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10455)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10455)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10455)/publications"},"_namespace":null},{"id":10456,"version":2,"created":1554929757000,"modified":1554929762000,"deprecated":false,"name":"Ubiquitin-like modifier-activating enzyme 1","accession":"P22314","gene":"UBA1","description":"Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2026846686262087,"antibodyCount":255,"monoclonalCount":35,"pubmedCount":null,"jensenScore":154.154979,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":50.01298100485643,"pubTatorScore":2.087001521285023,"self":"https://pharos.nih.gov/idg/api/v1/targets(10456)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":478,"href":"https://pharos.nih.gov/idg/api/v1/targets(10456)/properties"},"_links":{"count":1227,"href":"https://pharos.nih.gov/idg/api/v1/targets(10456)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10456)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10456)/publications"},"_namespace":null},{"id":10457,"version":3,"created":1554929763000,"modified":1555039389000,"deprecated":false,"name":"WD repeat-containing protein 5","accession":"P61964","gene":"WDR5","description":"Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.1007667937120416,"antibodyCount":299,"monoclonalCount":70,"pubmedCount":null,"jensenScore":115.427531,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":38,"knowledgeAvailability":39.760436414504134,"pubTatorScore":1.8283048026552953,"self":"https://pharos.nih.gov/idg/api/v1/targets(10457)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(10457)/properties"},"_links":{"count":1099,"href":"https://pharos.nih.gov/idg/api/v1/targets(10457)/links"},"_synonyms":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(10457)/synonyms"},"_publications":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10457)/publications"},"_namespace":null},{"id":10458,"version":2,"created":1554929783000,"modified":1554929787000,"deprecated":false,"name":"GMP reductase 1","accession":"P36959","gene":"GMPR","description":"Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2167083639999465,"antibodyCount":99,"monoclonalCount":8,"pubmedCount":null,"jensenScore":14.431459,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.57225718981989,"pubTatorScore":1.2537194449621216,"self":"https://pharos.nih.gov/idg/api/v1/targets(10458)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(10458)/properties"},"_links":{"count":918,"href":"https://pharos.nih.gov/idg/api/v1/targets(10458)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10458)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10458)/publications"},"_namespace":null},{"id":10459,"version":3,"created":1554929788000,"modified":1555039391000,"deprecated":false,"name":"Beta-adrenergic receptor kinase 2","accession":"P35626","gene":"GRK3","description":"Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.6215677566201625,"antibodyCount":309,"monoclonalCount":9,"pubmedCount":null,"jensenScore":40.827186,"patentCount":4304,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.7626547406340694,"self":"https://pharos.nih.gov/idg/api/v1/targets(10459)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(10459)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(10459)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10459)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(10459)/publications"},"_namespace":null},{"id":10460,"version":2,"created":1554929794000,"modified":1554929799000,"deprecated":false,"name":"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial","accession":"P36957","gene":"DLST","description":"The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.767752486025452,"antibodyCount":129,"monoclonalCount":24,"pubmedCount":null,"jensenScore":55.434732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.49378783402209,"pubTatorScore":1.711061119921464,"self":"https://pharos.nih.gov/idg/api/v1/targets(10460)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":457,"href":"https://pharos.nih.gov/idg/api/v1/targets(10460)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(10460)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10460)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(10460)/publications"},"_namespace":null},{"id":10461,"version":2,"created":1554929800000,"modified":1554929804000,"deprecated":false,"name":"APC membrane recruitment protein 1","accession":"Q5JTC6","gene":"AMER1","description":"Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7417818915757275,"antibodyCount":84,"monoclonalCount":8,"pubmedCount":null,"jensenScore":542.370174,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.721343901777345,"pubTatorScore":1.8339915257412163,"self":"https://pharos.nih.gov/idg/api/v1/targets(10461)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":433,"href":"https://pharos.nih.gov/idg/api/v1/targets(10461)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(10461)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10461)/synonyms"},"_publications":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(10461)/publications"},"_namespace":null},{"id":10462,"version":2,"created":1554929805000,"modified":1554929809000,"deprecated":false,"name":"Peroxisomal coenzyme A diphosphatase NUDT7","accession":"P0C024","gene":"NUDT7","description":"Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.7256747948041781,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.459524,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.87108046976795,"pubTatorScore":-0.22847939532991027,"self":"https://pharos.nih.gov/idg/api/v1/targets(10462)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10462)/properties"},"_links":{"count":905,"href":"https://pharos.nih.gov/idg/api/v1/targets(10462)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10462)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10462)/publications"},"_namespace":null},{"id":10463,"version":3,"created":1554929810000,"modified":1555039392000,"deprecated":false,"name":"Serpin B5","accession":"P36952","gene":"SERPINB5","description":"Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0457574905606752,"antibodyCount":385,"monoclonalCount":54,"pubmedCount":null,"jensenScore":1104.759943,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":32.89670055515265,"pubTatorScore":2.6513276108918453,"self":"https://pharos.nih.gov/idg/api/v1/targets(10463)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":518,"href":"https://pharos.nih.gov/idg/api/v1/targets(10463)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(10463)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10463)/synonyms"},"_publications":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10463)/publications"},"_namespace":null},{"id":10464,"version":2,"created":1554929818000,"modified":1554929822000,"deprecated":false,"name":"Eosinophil peroxidase","accession":"P11678","gene":"EPX","description":"Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.739132340475124,"antibodyCount":186,"monoclonalCount":87,"pubmedCount":null,"jensenScore":553.499734,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.793338939995184,"pubTatorScore":2.538081854366109,"self":"https://pharos.nih.gov/idg/api/v1/targets(10464)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":294,"href":"https://pharos.nih.gov/idg/api/v1/targets(10464)/properties"},"_links":{"count":874,"href":"https://pharos.nih.gov/idg/api/v1/targets(10464)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10464)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10464)/publications"},"_namespace":null},{"id":10465,"version":3,"created":1554929823000,"modified":1555039395000,"deprecated":false,"name":"C-type lectin domain family 3 member A","accession":"O75596","gene":"CLEC3A","description":"Promotes cell adhesion to laminin-332 and fibronectin.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.27390350536289143,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.347272,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":39,"knowledgeAvailability":15.224326200535009,"pubTatorScore":0.37003986352765256,"self":"https://pharos.nih.gov/idg/api/v1/targets(10465)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10465)/properties"},"_links":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(10465)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10465)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10465)/publications"},"_namespace":null},{"id":10466,"version":3,"created":1554929826000,"modified":1555039396000,"deprecated":false,"name":"Forkhead box protein H1","accession":"O75593","gene":"FOXH1","description":"Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.2021945996841796,"antibodyCount":185,"monoclonalCount":2,"pubmedCount":null,"jensenScore":153.752745,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":32.29278207581129,"pubTatorScore":1.8919977108061745,"self":"https://pharos.nih.gov/idg/api/v1/targets(10466)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(10466)/properties"},"_links":{"count":807,"href":"https://pharos.nih.gov/idg/api/v1/targets(10466)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10466)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10466)/publications"},"_namespace":null},{"id":10467,"version":2,"created":1554929830000,"modified":1554929838000,"deprecated":false,"name":"Metalloproteinase inhibitor 3","accession":"P35625","gene":"TIMP3","description":"Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7615749959237736,"antibodyCount":503,"monoclonalCount":86,"pubmedCount":null,"jensenScore":592.300195,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.965488397495484,"pubTatorScore":2.6654989044177144,"self":"https://pharos.nih.gov/idg/api/v1/targets(10467)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":558,"href":"https://pharos.nih.gov/idg/api/v1/targets(10467)/properties"},"_links":{"count":1248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10467)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(10467)/synonyms"},"_publications":{"count":256,"href":"https://pharos.nih.gov/idg/api/v1/targets(10467)/publications"},"_namespace":null},{"id":10468,"version":3,"created":1554929840000,"modified":1555039397000,"deprecated":false,"name":"Sterol regulatory element-binding protein 1","accession":"P36956","gene":"SREBF1","description":"Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.120749247840023,"antibodyCount":429,"monoclonalCount":100,"pubmedCount":null,"jensenScore":1267.35487,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":53.7776771987082,"pubTatorScore":2.6852840502129625,"self":"https://pharos.nih.gov/idg/api/v1/targets(10468)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":655,"href":"https://pharos.nih.gov/idg/api/v1/targets(10468)/properties"},"_links":{"count":1326,"href":"https://pharos.nih.gov/idg/api/v1/targets(10468)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(10468)/synonyms"},"_publications":{"count":308,"href":"https://pharos.nih.gov/idg/api/v1/targets(10468)/publications"},"_namespace":null},{"id":10469,"version":3,"created":1554929848000,"modified":1555039399000,"deprecated":false,"name":"Pigment epithelium-derived factor","accession":"P36955","gene":"SERPINF1","description":"Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1225589652492634,"antibodyCount":423,"monoclonalCount":140,"pubmedCount":null,"jensenScore":137.941505,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.00965272282855,"pubTatorScore":2.3878332246089147,"self":"https://pharos.nih.gov/idg/api/v1/targets(10469)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":647,"href":"https://pharos.nih.gov/idg/api/v1/targets(10469)/properties"},"_links":{"count":1295,"href":"https://pharos.nih.gov/idg/api/v1/targets(10469)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10469)/synonyms"},"_publications":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(10469)/publications"},"_namespace":null},{"id":10470,"version":3,"created":1554929857000,"modified":1555039401000,"deprecated":false,"name":"Peptidoglycan recognition protein 1","accession":"O75594","gene":"PGLYRP1","description":"Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3621381775200727,"antibodyCount":249,"monoclonalCount":53,"pubmedCount":null,"jensenScore":250.27434,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":24.05108584648359,"pubTatorScore":1.843645716028845,"self":"https://pharos.nih.gov/idg/api/v1/targets(10470)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":279,"href":"https://pharos.nih.gov/idg/api/v1/targets(10470)/properties"},"_links":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(10470)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10470)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10470)/publications"},"_namespace":null},{"id":10471,"version":2,"created":1554929861000,"modified":1554929864000,"deprecated":false,"name":"DNA-directed RNA polymerase II subunit RPB9","accession":"P36954","gene":"POLR2I","description":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2956027950070739,"antibodyCount":135,"monoclonalCount":15,"pubmedCount":null,"jensenScore":20.751223,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.09089466860047,"pubTatorScore":0.8883667114516471,"self":"https://pharos.nih.gov/idg/api/v1/targets(10471)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(10471)/properties"},"_links":{"count":927,"href":"https://pharos.nih.gov/idg/api/v1/targets(10471)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(10471)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10471)/publications"},"_namespace":null},{"id":10472,"version":2,"created":1554929865000,"modified":1554929870000,"deprecated":false,"name":"E3 ubiquitin-protein ligase MYCBP2","accession":"O75592","gene":"MYCBP2","description":"E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.779238346024858,"antibodyCount":32,"monoclonalCount":0,"pubmedCount":null,"jensenScore":593.856881,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.72266119203191,"pubTatorScore":1.0821867442068125,"self":"https://pharos.nih.gov/idg/api/v1/targets(10472)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":327,"href":"https://pharos.nih.gov/idg/api/v1/targets(10472)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(10472)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10472)/synonyms"},"_publications":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(10472)/publications"},"_namespace":null},{"id":10473,"version":2,"created":1554929871000,"modified":1554929874000,"deprecated":false,"name":"Phosphorylated CTD-interacting factor 1","accession":"Q9H4Z3","gene":"PCIF1","description":"May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7558748469866019,"antibodyCount":51,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.672349,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.41826052062297,"pubTatorScore":0.760386516922171,"self":"https://pharos.nih.gov/idg/api/v1/targets(10473)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(10473)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(10473)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10473)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10473)/publications"},"_namespace":null},{"id":10474,"version":2,"created":1554929875000,"modified":1554929879000,"deprecated":false,"name":"Zinc finger protein 335","accession":"Q9H4Z2","gene":"ZNF335","description":"Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.1733624700624008,"antibodyCount":83,"monoclonalCount":0,"pubmedCount":null,"jensenScore":14.818732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.087589166182276,"pubTatorScore":1.2780008881370877,"self":"https://pharos.nih.gov/idg/api/v1/targets(10474)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":291,"href":"https://pharos.nih.gov/idg/api/v1/targets(10474)/properties"},"_links":{"count":836,"href":"https://pharos.nih.gov/idg/api/v1/targets(10474)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10474)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10474)/publications"},"_namespace":null},{"id":10475,"version":2,"created":1554929880000,"modified":1554929884000,"deprecated":false,"name":"Nuclear transport factor 2","accession":"P61970","gene":"NUTF2","description":"Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.624032943086846,"antibodyCount":97,"monoclonalCount":24,"pubmedCount":null,"jensenScore":421.556479,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.511730526198306,"pubTatorScore":2.4273191755053745,"self":"https://pharos.nih.gov/idg/api/v1/targets(10475)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(10475)/properties"},"_links":{"count":1100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10475)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10475)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10475)/publications"},"_namespace":null},{"id":10476,"version":3,"created":1554929886000,"modified":1555039402000,"deprecated":false,"name":"Ras-related protein Rab-7b","accession":"Q96AH8","gene":"RAB7B","description":"Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":null,"antibodyCount":110,"monoclonalCount":29,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":12.256376254694883,"pubTatorScore":0.691670795038212,"self":"https://pharos.nih.gov/idg/api/v1/targets(10476)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":181,"href":"https://pharos.nih.gov/idg/api/v1/targets(10476)/properties"},"_links":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10476)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10476)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10476)/publications"},"_namespace":null},{"id":10477,"version":2,"created":1554929887000,"modified":1554929889000,"deprecated":false,"name":"Nucleoside diphosphate-linked moiety X motif 17","accession":"P0C025","gene":"NUDT17","description":"Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.024343649067729147,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.529166,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.91467930689138,"pubTatorScore":-0.49291494284397114,"self":"https://pharos.nih.gov/idg/api/v1/targets(10477)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(10477)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(10477)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10477)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10477)/publications"},"_namespace":null},{"id":10478,"version":2,"created":1554929890000,"modified":1554929895000,"deprecated":false,"name":"Gap junction beta-1 protein","accession":"P08034","gene":"GJB1","description":"One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.931146506328502,"antibodyCount":295,"monoclonalCount":134,"pubmedCount":null,"jensenScore":861.609743,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.7289745226083,"pubTatorScore":2.7456101441989973,"self":"https://pharos.nih.gov/idg/api/v1/targets(10478)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(10478)/properties"},"_links":{"count":1041,"href":"https://pharos.nih.gov/idg/api/v1/targets(10478)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10478)/synonyms"},"_publications":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(10478)/publications"},"_namespace":null},{"id":10479,"version":2,"created":1554929896000,"modified":1554929900000,"deprecated":false,"name":"Tight junction-associated protein 1","accession":"Q5JTD0","gene":"TJAP1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9117852136343014,"antibodyCount":120,"monoclonalCount":8,"pubmedCount":null,"jensenScore":75.908581,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.01147644239602,"pubTatorScore":1.267953529051343,"self":"https://pharos.nih.gov/idg/api/v1/targets(10479)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":372,"href":"https://pharos.nih.gov/idg/api/v1/targets(10479)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10479)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(10479)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10479)/publications"},"_namespace":null},{"id":10480,"version":3,"created":1554929901000,"modified":1555039403000,"deprecated":false,"name":"Heterogeneous nuclear ribonucleoprotein K","accession":"P61978","gene":"HNRNPK","description":"One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4772311451253066,"antibodyCount":427,"monoclonalCount":118,"pubmedCount":null,"jensenScore":291.679864,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":52.53266418699468,"pubTatorScore":2.328360290157982,"self":"https://pharos.nih.gov/idg/api/v1/targets(10480)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":671,"href":"https://pharos.nih.gov/idg/api/v1/targets(10480)/properties"},"_links":{"count":1450,"href":"https://pharos.nih.gov/idg/api/v1/targets(10480)/links"},"_synonyms":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(10480)/synonyms"},"_publications":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10480)/publications"},"_namespace":null},{"id":10481,"version":2,"created":1554929912000,"modified":1554929913000,"deprecated":false,"name":"Neuroblastoma breakpoint family member 6","accession":"Q5VWK0","gene":"NBPF6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.314195192276776,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10481)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(10481)/properties"},"_links":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(10481)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(10481)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10481)/publications"},"_namespace":null},{"id":10482,"version":2,"created":1554929913000,"modified":1554929916000,"deprecated":false,"name":"Zinc finger with UFM1-specific peptidase domain protein","accession":"Q96AP4","gene":"ZUFSP","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6605736232768569,"antibodyCount":92,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.076923,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.801892632931043,"pubTatorScore":-1.1139437866015358,"self":"https://pharos.nih.gov/idg/api/v1/targets(10482)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(10482)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(10482)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10482)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10482)/publications"},"_namespace":null},{"id":10483,"version":3,"created":1554929917000,"modified":1555039405000,"deprecated":false,"name":"Interleukin-23 receptor","accession":"Q5VWK5","gene":"IL23R","description":"Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.107232762020356,"antibodyCount":383,"monoclonalCount":170,"pubmedCount":null,"jensenScore":113.898438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.18596255515151,"pubTatorScore":2.5540013957904057,"self":"https://pharos.nih.gov/idg/api/v1/targets(10483)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":582,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/properties"},"_links":{"count":710,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/synonyms"},"_publications":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(10483)/publications"},"_namespace":null},{"id":10484,"version":3,"created":1554929923000,"modified":1555039408000,"deprecated":false,"name":"Adrenocortical dysplasia protein homolog","accession":"Q96AP0","gene":"ACD","description":"Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4299862409893676,"antibodyCount":205,"monoclonalCount":58,"pubmedCount":null,"jensenScore":246.514018,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":33.99465705417439,"pubTatorScore":1.892280145990796,"self":"https://pharos.nih.gov/idg/api/v1/targets(10484)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(10484)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(10484)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10484)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10484)/publications"},"_namespace":null},{"id":10485,"version":2,"created":1554929928000,"modified":1554929931000,"deprecated":false,"name":"Mediator of RNA polymerase II transcription subunit 6","accession":"O75586","gene":"MED6","description":"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9821994309886082,"antibodyCount":215,"monoclonalCount":18,"pubmedCount":null,"jensenScore":8.881536,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.75025504179183,"pubTatorScore":0.9660012803224615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10485)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(10485)/properties"},"_links":{"count":1000,"href":"https://pharos.nih.gov/idg/api/v1/targets(10485)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10485)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10485)/publications"},"_namespace":null},{"id":10486,"version":3,"created":1554929931000,"modified":1555039409000,"deprecated":false,"name":"WD40 repeat-containing protein SMU1","accession":"Q2TAY7","gene":"SMU1","description":"(Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9697707803451858,"antibodyCount":67,"monoclonalCount":9,"pubmedCount":null,"jensenScore":90.624848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.96121885504348,"pubTatorScore":1.3560258380612067,"self":"https://pharos.nih.gov/idg/api/v1/targets(10486)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/properties"},"_links":{"count":1002,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10486)/publications"},"_namespace":null},{"id":10487,"version":3,"created":1554929936000,"modified":1555039410000,"deprecated":false,"name":"Ribosomal protein S6 kinase alpha-5","accession":"O75582","gene":"RPS6KA5","description":"Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.9700366029047989,"antibodyCount":671,"monoclonalCount":45,"pubmedCount":null,"jensenScore":92.612963,"patentCount":10862,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":54.3640914549702,"pubTatorScore":1.8829806149653723,"self":"https://pharos.nih.gov/idg/api/v1/targets(10487)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":533,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10487)/publications"},"_namespace":null},{"id":10488,"version":3,"created":1554929954000,"modified":1555039412000,"deprecated":false,"name":"Dapper homolog 3","accession":"Q96B18","gene":"DACT3","description":"May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7558203898740499,"antibodyCount":151,"monoclonalCount":44,"pubmedCount":null,"jensenScore":56.785347,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":24.421974600907674,"pubTatorScore":2.0238058755664974,"self":"https://pharos.nih.gov/idg/api/v1/targets(10488)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(10488)/properties"},"_links":{"count":825,"href":"https://pharos.nih.gov/idg/api/v1/targets(10488)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10488)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10488)/publications"},"_namespace":null},{"id":10489,"version":3,"created":1554929957000,"modified":1555039413000,"deprecated":false,"name":"Low-density lipoprotein receptor-related protein 6","accession":"O75581","gene":"LRP6","description":"Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.447784561979198,"antibodyCount":424,"monoclonalCount":47,"pubmedCount":null,"jensenScore":273.247753,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":52.59581302919862,"pubTatorScore":2.243883843179545,"self":"https://pharos.nih.gov/idg/api/v1/targets(10489)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(10489)/properties"},"_links":{"count":1213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10489)/links"},"_synonyms":{"count":156,"href":"https://pharos.nih.gov/idg/api/v1/targets(10489)/synonyms"},"_publications":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(10489)/publications"},"_namespace":null},{"id":10490,"version":3,"created":1554929965000,"modified":1555039415000,"deprecated":false,"name":"Serine/threonine-protein kinase A-Raf","accession":"P10398","gene":"ARAF","description":"Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.4661517117086587,"antibodyCount":465,"monoclonalCount":115,"pubmedCount":null,"jensenScore":277.623098,"patentCount":15436,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.68170568995153,"pubTatorScore":2.0164157888608147,"self":"https://pharos.nih.gov/idg/api/v1/targets(10490)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(10490)/properties"},"_links":{"count":1078,"href":"https://pharos.nih.gov/idg/api/v1/targets(10490)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(10490)/synonyms"},"_publications":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10490)/publications"},"_namespace":null},{"id":10491,"version":3,"created":1554929973000,"modified":1555039416000,"deprecated":false,"name":"Endothelial cell-selective adhesion molecule","accession":"Q96AP7","gene":"ESAM","description":"Can mediate aggregation most likely through a homophilic molecular interaction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.680821043658069,"antibodyCount":299,"monoclonalCount":77,"pubmedCount":null,"jensenScore":373.853849,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":32.787131079296316,"pubTatorScore":1.4634048871812306,"self":"https://pharos.nih.gov/idg/api/v1/targets(10491)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(10491)/properties"},"_links":{"count":960,"href":"https://pharos.nih.gov/idg/api/v1/targets(10491)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10491)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10491)/publications"},"_namespace":null},{"id":10492,"version":3,"created":1554929977000,"modified":1555039418000,"deprecated":false,"name":"RAD51-associated protein 1","accession":"Q96B01","gene":"RAD51AP1","description":"May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0283679068232432,"antibodyCount":136,"monoclonalCount":4,"pubmedCount":null,"jensenScore":11.638615,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":32.800724055784045,"pubTatorScore":1.0630456233255081,"self":"https://pharos.nih.gov/idg/api/v1/targets(10492)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(10492)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(10492)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10492)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10492)/publications"},"_namespace":null},{"id":10493,"version":3,"created":1554929982000,"modified":1555039419000,"deprecated":false,"name":"Epididymal secretory protein E1","accession":"P61916","gene":"NPC2","description":"Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2716819371246326,"antibodyCount":172,"monoclonalCount":10,"pubmedCount":null,"jensenScore":173.499802,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":43.66665633071828,"pubTatorScore":2.2148117964618623,"self":"https://pharos.nih.gov/idg/api/v1/targets(10493)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(10493)/properties"},"_links":{"count":1188,"href":"https://pharos.nih.gov/idg/api/v1/targets(10493)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10493)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10493)/publications"},"_namespace":null},{"id":10494,"version":3,"created":1554929989000,"modified":1555039421000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 W","accession":"Q96B02","gene":"UBE2W","description":"Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386). Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:23560854, PubMed:23696636, PubMed:25436519). Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:19111657, PubMed:21229326). In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (PubMed:25436519).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0570560216774818,"antibodyCount":108,"monoclonalCount":12,"pubmedCount":null,"jensenScore":7.309259,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":35.94999360309892,"pubTatorScore":1.0022174826359749,"self":"https://pharos.nih.gov/idg/api/v1/targets(10494)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(10494)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(10494)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10494)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10494)/publications"},"_namespace":null},{"id":10495,"version":2,"created":1554929993000,"modified":1554929997000,"deprecated":false,"name":"Putative hexokinase HKDC1","accession":"Q2TB90","gene":"HKDC1","description":null,"idgFamily":"Kinase","idgTDL":"Tbio","novelty":-0.7661803241765883,"antibodyCount":104,"monoclonalCount":11,"pubmedCount":null,"jensenScore":4.807972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.0261748292304,"pubTatorScore":0.6658935142902243,"self":"https://pharos.nih.gov/idg/api/v1/targets(10495)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(10495)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(10495)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10495)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10495)/publications"},"_namespace":null},{"id":10496,"version":2,"created":1554929998000,"modified":1554930000000,"deprecated":false,"name":"Integrin alpha-10","accession":"O75578","gene":"ITGA10","description":"Integrin alpha-10/beta-1 is a receptor for collagen.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8680149380114757,"antibodyCount":15,"monoclonalCount":3,"pubmedCount":null,"jensenScore":7.536378,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.20584697175776,"pubTatorScore":1.0526571657421544,"self":"https://pharos.nih.gov/idg/api/v1/targets(10496)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(10496)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(10496)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10496)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10496)/publications"},"_namespace":null},{"id":10497,"version":2,"created":1554930001000,"modified":1554930005000,"deprecated":false,"name":"Nucleoside diphosphate kinase B","accession":"P22392","gene":"NME1-NME2","description":"Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-2.8500269170366197,"antibodyCount":85,"monoclonalCount":18,"pubmedCount":null,"jensenScore":1033.027092,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.16924389292252,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(10497)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":440,"href":"https://pharos.nih.gov/idg/api/v1/targets(10497)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(10497)/links"},"_synonyms":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(10497)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10497)/publications"},"_namespace":null},{"id":10498,"version":3,"created":1554930006000,"modified":1555039422000,"deprecated":false,"name":"DNA-directed RNA polymerase III subunit RPC9","accession":"O75575","gene":"CRCP","description":"Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.9521043212082039,"antibodyCount":37,"monoclonalCount":1,"pubmedCount":null,"jensenScore":80.554243,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.8986128434063,"pubTatorScore":2.253141762646495,"self":"https://pharos.nih.gov/idg/api/v1/targets(10498)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10498)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(10498)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10498)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10498)/publications"},"_namespace":null},{"id":10499,"version":2,"created":1554930011000,"modified":1554930013000,"deprecated":false,"name":"DNA repair protein SWI5 homolog","accession":"Q1ZZU3","gene":"SWI5","description":"Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.3226621925153836,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":21.101153,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.574257604972807,"pubTatorScore":0.9786658699741261,"self":"https://pharos.nih.gov/idg/api/v1/targets(10499)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(10499)/properties"},"_links":{"count":921,"href":"https://pharos.nih.gov/idg/api/v1/targets(10499)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10499)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10499)/publications"},"_namespace":null},{"id":10500,"version":3,"created":1554930014000,"modified":1555039424000,"deprecated":false,"name":"Peptide chain release factor 1, mitochondrial","accession":"O75570","gene":"MTRF1","description":"Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.8670604162229517,"antibodyCount":99,"monoclonalCount":9,"pubmedCount":null,"jensenScore":6.974549,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":20,"knowledgeAvailability":29.99168937488609,"pubTatorScore":2.0150901786196767,"self":"https://pharos.nih.gov/idg/api/v1/targets(10500)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(10500)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(10500)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10500)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10500)/publications"},"_namespace":null},{"id":10501,"version":2,"created":1554930018000,"modified":1554930021000,"deprecated":false,"name":"Cytochrome c oxidase assembly factor 6 homolog","accession":"Q5JTJ3","gene":"COA6","description":"Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.7958800173440752,"antibodyCount":59,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.218254,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.552565313885296,"pubTatorScore":0.7494785989393855,"self":"https://pharos.nih.gov/idg/api/v1/targets(10501)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10501)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(10501)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10501)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10501)/publications"},"_namespace":null},{"id":10502,"version":2,"created":1554930022000,"modified":1554930041000,"deprecated":false,"name":"Melanocortin receptor 5","accession":"P33032","gene":"MC5R","description":"Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-1.8944656316616288,"antibodyCount":265,"monoclonalCount":21,"pubmedCount":null,"jensenScore":75.222052,"patentCount":15856,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.21980650206885,"pubTatorScore":2.0521883813463067,"self":"https://pharos.nih.gov/idg/api/v1/targets(10502)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(10502)/properties"},"_links":{"count":482,"href":"https://pharos.nih.gov/idg/api/v1/targets(10502)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10502)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10502)/publications"},"_namespace":null},{"id":10503,"version":2,"created":1554930042000,"modified":1554930042000,"deprecated":false,"name":"Putative ankyrin repeat domain-containing protein 30B-like","accession":"A7E2S9","gene":"ANKRD30BL","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.306138196585474,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10503)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10503)/properties"},"_links":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(10503)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(10503)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10503)/publications"},"_namespace":null},{"id":10504,"version":2,"created":1554930043000,"modified":1554930047000,"deprecated":false,"name":"Short transient receptor potential channel 1","accession":"P48995","gene":"TRPC1","description":"Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.5258857633896317,"antibodyCount":162,"monoclonalCount":14,"pubmedCount":null,"jensenScore":340.728868,"patentCount":78385,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.688129522591446,"pubTatorScore":2.363215165596943,"self":"https://pharos.nih.gov/idg/api/v1/targets(10504)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":566,"href":"https://pharos.nih.gov/idg/api/v1/targets(10504)/properties"},"_links":{"count":1166,"href":"https://pharos.nih.gov/idg/api/v1/targets(10504)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10504)/synonyms"},"_publications":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(10504)/publications"},"_namespace":null},{"id":10505,"version":2,"created":1554930049000,"modified":1554930050000,"deprecated":false,"name":"NANOG neighbor homeobox","accession":"Q7Z5D8","gene":"NANOGNB","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.888241789311277,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10505)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10505)/properties"},"_links":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10505)/links"},"_synonyms":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(10505)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10505)/publications"},"_namespace":null},{"id":10506,"version":3,"created":1554930050000,"modified":1555039426000,"deprecated":false,"name":"60S ribosomal protein L37","accession":"P61927","gene":"RPL37","description":"Binds to the 23S rRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4328051273219098,"antibodyCount":108,"monoclonalCount":2,"pubmedCount":null,"jensenScore":25.196389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":69,"knowledgeAvailability":36.720745582632084,"pubTatorScore":1.217594135748422,"self":"https://pharos.nih.gov/idg/api/v1/targets(10506)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(10506)/properties"},"_links":{"count":947,"href":"https://pharos.nih.gov/idg/api/v1/targets(10506)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10506)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10506)/publications"},"_namespace":null},{"id":10507,"version":2,"created":1554930054000,"modified":1554930058000,"deprecated":false,"name":"cAMP-dependent protein kinase inhibitor alpha","accession":"P61925","gene":"PKIA","description":"Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.2705780318091942,"antibodyCount":34,"monoclonalCount":5,"pubmedCount":null,"jensenScore":17.066873,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.37103422493116,"pubTatorScore":1.0499252302237667,"self":"https://pharos.nih.gov/idg/api/v1/targets(10507)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(10507)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(10507)/links"},"_synonyms":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10507)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10507)/publications"},"_namespace":null},{"id":10508,"version":3,"created":1554930058000,"modified":1555039428000,"deprecated":false,"name":"C-C motif chemokine 1","accession":"P22362","gene":"CCL1","description":"Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.476158622909753,"antibodyCount":223,"monoclonalCount":55,"pubmedCount":null,"jensenScore":279.09751,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":23.263897829173757,"pubTatorScore":1.9329470246933482,"self":"https://pharos.nih.gov/idg/api/v1/targets(10508)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":204,"href":"https://pharos.nih.gov/idg/api/v1/targets(10508)/properties"},"_links":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(10508)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10508)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10508)/publications"},"_namespace":null},{"id":10509,"version":2,"created":1554930061000,"modified":1554930066000,"deprecated":false,"name":"Interferon-inducible double-stranded RNA-dependent protein kinase activator A","accession":"O75569","gene":"PRKRA","description":"Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.5172747304213707,"antibodyCount":299,"monoclonalCount":46,"pubmedCount":null,"jensenScore":34.266246,"patentCount":12843,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.062221632048654,"pubTatorScore":1.723361775464014,"self":"https://pharos.nih.gov/idg/api/v1/targets(10509)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(10509)/properties"},"_links":{"count":1183,"href":"https://pharos.nih.gov/idg/api/v1/targets(10509)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10509)/synonyms"},"_publications":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10509)/publications"},"_namespace":null},{"id":10510,"version":2,"created":1554930067000,"modified":1554930070000,"deprecated":false,"name":"Transcription elongation regulator 1-like protein","accession":"Q5VWI1","gene":"TCERG1L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.48790625092762047,"antibodyCount":62,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.916063,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.46751333773773,"pubTatorScore":0.5358665555155238,"self":"https://pharos.nih.gov/idg/api/v1/targets(10510)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(10510)/properties"},"_links":{"count":693,"href":"https://pharos.nih.gov/idg/api/v1/targets(10510)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10510)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10510)/publications"},"_namespace":null},{"id":10511,"version":2,"created":1554930070000,"modified":1554930071000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 24","accession":"Q0WX57","gene":"USP17L30","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.31907253608798325,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.071592,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.3550947011680767,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10511)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10511)/properties"},"_links":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(10511)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(10511)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10511)/publications"},"_namespace":null},{"id":10512,"version":2,"created":1554930071000,"modified":1554930072000,"deprecated":false,"name":"Jerky protein homolog","accession":"O75564","gene":"JRK","description":"May bind DNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.59041853937524,"pubTatorScore":0.8980849480743152,"self":"https://pharos.nih.gov/idg/api/v1/targets(10512)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10512)/properties"},"_links":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10512)/links"},"_synonyms":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(10512)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10512)/publications"},"_namespace":null},{"id":10513,"version":2,"created":1554930072000,"modified":1554930078000,"deprecated":false,"name":"Src kinase-associated phosphoprotein 2","accession":"O75563","gene":"SKAP2","description":"May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7644715530924513,"antibodyCount":170,"monoclonalCount":0,"pubmedCount":null,"jensenScore":571.713852,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.44539280541622,"pubTatorScore":1.7983587484315815,"self":"https://pharos.nih.gov/idg/api/v1/targets(10513)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(10513)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(10513)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10513)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10513)/publications"},"_namespace":null},{"id":10514,"version":2,"created":1554930079000,"modified":1554930081000,"deprecated":false,"name":"Transmembrane protein 143","accession":"Q96AN5","gene":"TMEM143","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.305221153793607,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10514)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(10514)/properties"},"_links":{"count":842,"href":"https://pharos.nih.gov/idg/api/v1/targets(10514)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10514)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10514)/publications"},"_namespace":null},{"id":10515,"version":2,"created":1554930082000,"modified":1554930087000,"deprecated":false,"name":"Hepatocyte nuclear factor 1-beta","accession":"P35680","gene":"HNF1B","description":"Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.63510020836127,"antibodyCount":403,"monoclonalCount":163,"pubmedCount":null,"jensenScore":401.501532,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.939772090958144,"pubTatorScore":2.586530522019349,"self":"https://pharos.nih.gov/idg/api/v1/targets(10515)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":483,"href":"https://pharos.nih.gov/idg/api/v1/targets(10515)/properties"},"_links":{"count":521,"href":"https://pharos.nih.gov/idg/api/v1/targets(10515)/links"},"_synonyms":{"count":140,"href":"https://pharos.nih.gov/idg/api/v1/targets(10515)/synonyms"},"_publications":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(10515)/publications"},"_namespace":null},{"id":10516,"version":2,"created":1554930088000,"modified":1554930088000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase 17-like protein 13","accession":"C9JLJ4","gene":"USP17L13","description":"Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":3.8463358664104392,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10516)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10516)/properties"},"_links":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10516)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10516)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10516)/publications"},"_namespace":null},{"id":10517,"version":3,"created":1554930088000,"modified":1554930374000,"deprecated":false,"name":"Insulin-like growth factor 1 receptor","accession":"P08069","gene":"IGF1R","description":"When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.3716826066969547,"antibodyCount":1686,"monoclonalCount":542,"pubmedCount":null,"jensenScore":2419.512187,"patentCount":286378,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":66.19356772462868,"pubTatorScore":3.32477653237863,"self":"https://pharos.nih.gov/idg/api/v1/targets(10517)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1400,"href":"https://pharos.nih.gov/idg/api/v1/targets(10517)/properties"},"_links":{"count":2618,"href":"https://pharos.nih.gov/idg/api/v1/targets(10517)/links"},"_synonyms":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10517)/synonyms"},"_publications":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(10517)/publications"},"_namespace":null},{"id":10518,"version":2,"created":1554930381000,"modified":1554930389000,"deprecated":false,"name":"Glutathione peroxidase 3","accession":"P22352","gene":"GPX3","description":"Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.6827078043696106,"antibodyCount":196,"monoclonalCount":19,"pubmedCount":null,"jensenScore":472.299682,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.973514887864454,"pubTatorScore":2.482375980035449,"self":"https://pharos.nih.gov/idg/api/v1/targets(10518)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(10518)/properties"},"_links":{"count":1038,"href":"https://pharos.nih.gov/idg/api/v1/targets(10518)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10518)/synonyms"},"_publications":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10518)/publications"},"_namespace":null},{"id":10519,"version":3,"created":1554930390000,"modified":1555039428000,"deprecated":false,"name":"Coatomer subunit zeta-1","accession":"P61923","gene":"COPZ1","description":"The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6192997286071356,"antibodyCount":151,"monoclonalCount":1,"pubmedCount":null,"jensenScore":43.165899,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":39.783863478363834,"pubTatorScore":1.1438323161152084,"self":"https://pharos.nih.gov/idg/api/v1/targets(10519)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":302,"href":"https://pharos.nih.gov/idg/api/v1/targets(10519)/properties"},"_links":{"count":1068,"href":"https://pharos.nih.gov/idg/api/v1/targets(10519)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10519)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10519)/publications"},"_namespace":null},{"id":10520,"version":2,"created":1554930395000,"modified":1554930397000,"deprecated":false,"name":"Cortexin-1","accession":"P60606","gene":"CTXN1","description":"May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.1673173403940045,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.396825,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.985503329571625,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10520)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(10520)/properties"},"_links":{"count":759,"href":"https://pharos.nih.gov/idg/api/v1/targets(10520)/links"},"_synonyms":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(10520)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10520)/publications"},"_namespace":null},{"id":10521,"version":2,"created":1554930398000,"modified":1554930402000,"deprecated":false,"name":"Mas-related G-protein coupled receptor member F","accession":"Q96AM1","gene":"MRGPRF","description":"Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.4877037344562328,"antibodyCount":184,"monoclonalCount":21,"pubmedCount":null,"jensenScore":2.280892,"patentCount":4251,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.78404348040285,"pubTatorScore":2.4394496391149034,"self":"https://pharos.nih.gov/idg/api/v1/targets(10521)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(10521)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(10521)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10521)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10521)/publications"},"_namespace":null},{"id":10522,"version":2,"created":1554930403000,"modified":1554930407000,"deprecated":false,"name":"Ubiquitin-conjugating enzyme E2 G2","accession":"P60604","gene":"UBE2G2","description":"Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.206067131444112,"antibodyCount":270,"monoclonalCount":151,"pubmedCount":null,"jensenScore":15.435972,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.96478538902812,"pubTatorScore":1.5666670124441113,"self":"https://pharos.nih.gov/idg/api/v1/targets(10522)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(10522)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(10522)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10522)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10522)/publications"},"_namespace":null},{"id":10523,"version":2,"created":1554930408000,"modified":1554930411000,"deprecated":false,"name":"Autophagy-related protein 2 homolog A","accession":"Q2TAZ0","gene":"ATG2A","description":"Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6923012388124706,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.621688,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.35253229076101,"pubTatorScore":0.37740169792321443,"self":"https://pharos.nih.gov/idg/api/v1/targets(10523)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":261,"href":"https://pharos.nih.gov/idg/api/v1/targets(10523)/properties"},"_links":{"count":938,"href":"https://pharos.nih.gov/idg/api/v1/targets(10523)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10523)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10523)/publications"},"_namespace":null},{"id":10524,"version":3,"created":1554930412000,"modified":1555039431000,"deprecated":false,"name":"Syntaxin-11","accession":"O75558","gene":"STX11","description":"SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6148370044087643,"antibodyCount":136,"monoclonalCount":10,"pubmedCount":null,"jensenScore":44.963804,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":43,"knowledgeAvailability":38.91192317664894,"pubTatorScore":1.6521728142371026,"self":"https://pharos.nih.gov/idg/api/v1/targets(10524)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":395,"href":"https://pharos.nih.gov/idg/api/v1/targets(10524)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(10524)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10524)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10524)/publications"},"_namespace":null},{"id":10525,"version":3,"created":1554930417000,"modified":1555039434000,"deprecated":false,"name":"Mammaglobin-B","accession":"O75556","gene":"SCGB2A1","description":"May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3075690750144213,"antibodyCount":143,"monoclonalCount":6,"pubmedCount":null,"jensenScore":210.564706,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":57,"knowledgeAvailability":14.357408884937675,"pubTatorScore":2.312657669751822,"self":"https://pharos.nih.gov/idg/api/v1/targets(10525)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":188,"href":"https://pharos.nih.gov/idg/api/v1/targets(10525)/properties"},"_links":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(10525)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10525)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10525)/publications"},"_namespace":null},{"id":10526,"version":2,"created":1554930419000,"modified":1554930419000,"deprecated":false,"name":"Endogenous retrovirus group FC1 member 1 Env polyprotein","accession":"P60608","gene":"ERVFC1-1","description":"Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.2726201093561018,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10526)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10526)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10526)/links"},"_synonyms":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10526)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10526)/publications"},"_namespace":null},{"id":10527,"version":3,"created":1554930419000,"modified":1555039435000,"deprecated":false,"name":"Disabled homolog 1","accession":"O75553","gene":"DAB1","description":"Adapter molecule functioning in neural development. May regulate SIAH1 activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.36015144416351713,"antibodyCount":395,"monoclonalCount":13,"pubmedCount":null,"jensenScore":2.977124,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":40.7573262823142,"pubTatorScore":1.869466638842081,"self":"https://pharos.nih.gov/idg/api/v1/targets(10527)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(10527)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(10527)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10527)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10527)/publications"},"_namespace":null},{"id":10528,"version":3,"created":1554930425000,"modified":1555039436000,"deprecated":false,"name":"WW domain-binding protein 4","accession":"O75554","gene":"WBP4","description":"Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8363023520184139,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.781469,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":38.08234174087193,"pubTatorScore":0.765234490390472,"self":"https://pharos.nih.gov/idg/api/v1/targets(10528)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(10528)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(10528)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10528)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10528)/publications"},"_namespace":null},{"id":10529,"version":2,"created":1554930430000,"modified":1554930432000,"deprecated":false,"name":"Cylicin-1","accession":"P35663","gene":"CYLC1","description":"Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-2.2009056205075748,"antibodyCount":29,"monoclonalCount":15,"pubmedCount":null,"jensenScore":155.262297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.974081328269754,"pubTatorScore":0.3832166320459405,"self":"https://pharos.nih.gov/idg/api/v1/targets(10529)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10529)/properties"},"_links":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(10529)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10529)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10529)/publications"},"_namespace":null},{"id":10530,"version":3,"created":1554930432000,"modified":1555039439000,"deprecated":false,"name":"C-type lectin domain family 12 member A","accession":"Q5QGZ9","gene":"CLEC12A","description":"Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3865569399160398,"antibodyCount":233,"monoclonalCount":45,"pubmedCount":null,"jensenScore":26.752783,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":23,"knowledgeAvailability":20.276743225276313,"pubTatorScore":1.538864234424769,"self":"https://pharos.nih.gov/idg/api/v1/targets(10530)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":236,"href":"https://pharos.nih.gov/idg/api/v1/targets(10530)/properties"},"_links":{"count":782,"href":"https://pharos.nih.gov/idg/api/v1/targets(10530)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10530)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10530)/publications"},"_namespace":null},{"id":10531,"version":3,"created":1554930437000,"modified":1555039440000,"deprecated":false,"name":"UPF0602 protein C4orf47","accession":"A7E2U8","gene":"C4orf47","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.9030899869919435,"antibodyCount":17,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.111111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":0.0,"pubTatorScore":-0.6478174818886375,"self":"https://pharos.nih.gov/idg/api/v1/targets(10531)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(10531)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(10531)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10531)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10531)/publications"},"_namespace":null},{"id":10532,"version":2,"created":1554930440000,"modified":1554930450000,"deprecated":false,"name":"Copper-transporting ATPase 2","accession":"P35670","gene":"ATP7B","description":"Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.9094950585759567,"antibodyCount":355,"monoclonalCount":130,"pubmedCount":null,"jensenScore":814.521561,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.40523517553027,"pubTatorScore":2.877328030611037,"self":"https://pharos.nih.gov/idg/api/v1/targets(10532)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":669,"href":"https://pharos.nih.gov/idg/api/v1/targets(10532)/properties"},"_links":{"count":1309,"href":"https://pharos.nih.gov/idg/api/v1/targets(10532)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(10532)/synonyms"},"_publications":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(10532)/publications"},"_namespace":null},{"id":10533,"version":2,"created":1554930452000,"modified":1554930458000,"deprecated":false,"name":"RRP12-like protein","accession":"Q5JTH9","gene":"RRP12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7931415396170052,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":6.031083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.018170482513554,"pubTatorScore":0.42886712918966213,"self":"https://pharos.nih.gov/idg/api/v1/targets(10533)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(10533)/properties"},"_links":{"count":948,"href":"https://pharos.nih.gov/idg/api/v1/targets(10533)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10533)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10533)/publications"},"_namespace":null},{"id":10534,"version":3,"created":1554930459000,"modified":1555039441000,"deprecated":false,"name":"Protein RIC-3","accession":"Q7Z5B4","gene":"RIC3","description":"Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.429874627132471,"antibodyCount":67,"monoclonalCount":2,"pubmedCount":null,"jensenScore":30.681411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":25.78694527316381,"pubTatorScore":1.4934580370531503,"self":"https://pharos.nih.gov/idg/api/v1/targets(10534)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(10534)/properties"},"_links":{"count":943,"href":"https://pharos.nih.gov/idg/api/v1/targets(10534)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10534)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10534)/publications"},"_namespace":null},{"id":10535,"version":3,"created":1554930466000,"modified":1555039442000,"deprecated":false,"name":"Reactive oxygen species modulator 1","accession":"P60602","gene":"ROMO1","description":"Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5915680375431749,"antibodyCount":80,"monoclonalCount":57,"pubmedCount":null,"jensenScore":39.54793,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.72292929897766,"pubTatorScore":1.5280377785584842,"self":"https://pharos.nih.gov/idg/api/v1/targets(10535)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":282,"href":"https://pharos.nih.gov/idg/api/v1/targets(10535)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(10535)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10535)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10535)/publications"},"_namespace":null},{"id":10536,"version":2,"created":1554930471000,"modified":1554930474000,"deprecated":false,"name":"Sorting nexin-30","accession":"Q5VWJ9","gene":"SNX30","description":"May be involved in several stages of intracellular trafficking.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":80,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.459569657933184,"pubTatorScore":-0.062148240821651324,"self":"https://pharos.nih.gov/idg/api/v1/targets(10536)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(10536)/properties"},"_links":{"count":897,"href":"https://pharos.nih.gov/idg/api/v1/targets(10536)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10536)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10536)/publications"},"_namespace":null},{"id":10537,"version":2,"created":1554930475000,"modified":1554930477000,"deprecated":false,"name":"Actin-like protein 8","accession":"Q9H568","gene":"ACTL8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.553276045702805,"antibodyCount":115,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.129167,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.65971922812161,"pubTatorScore":0.24303804868629444,"self":"https://pharos.nih.gov/idg/api/v1/targets(10537)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(10537)/properties"},"_links":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(10537)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10537)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10537)/publications"},"_namespace":null},{"id":10538,"version":2,"created":1554930477000,"modified":1554930480000,"deprecated":false,"name":"Zinc finger protein 821","accession":"O75541","gene":"ZNF821","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.07918124778480276,"antibodyCount":63,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.734368026928927,"pubTatorScore":0.33099319008845796,"self":"https://pharos.nih.gov/idg/api/v1/targets(10538)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(10538)/properties"},"_links":{"count":828,"href":"https://pharos.nih.gov/idg/api/v1/targets(10538)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10538)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10538)/publications"},"_namespace":null},{"id":10539,"version":2,"created":1554930482000,"modified":1554930489000,"deprecated":false,"name":"BRCA2-interacting transcriptional repressor EMSY","accession":"Q7Z589","gene":"EMSY","description":"Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4649754034149878,"antibodyCount":115,"monoclonalCount":21,"pubmedCount":null,"jensenScore":32.040486,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.5100838905796932,"self":"https://pharos.nih.gov/idg/api/v1/targets(10539)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(10539)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(10539)/links"},"_synonyms":{"count":132,"href":"https://pharos.nih.gov/idg/api/v1/targets(10539)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10539)/publications"},"_namespace":null},{"id":10540,"version":4,"created":1554930490000,"modified":1555039444000,"deprecated":false,"name":"Proto-oncogene tyrosine-protein kinase Src","accession":"P12931","gene":"SRC","description":"Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity).","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-4.002919564528269,"antibodyCount":1455,"monoclonalCount":287,"pubmedCount":null,"jensenScore":9201.686477,"patentCount":365075,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":64.84868539215226,"pubTatorScore":3.5182258301033285,"self":"https://pharos.nih.gov/idg/api/v1/targets(10540)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1894,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/properties"},"_links":{"count":2603,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/links"},"_synonyms":{"count":445,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/synonyms"},"_publications":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(10540)/publications"},"_namespace":null},{"id":10541,"version":2,"created":1554930738000,"modified":1554930744000,"deprecated":false,"name":"AT-hook-containing transcription factor","accession":"Q7Z591","gene":"AKNA","description":"Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.119600785133339,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":13.866161,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.868174184958292,"pubTatorScore":0.9607544271171863,"self":"https://pharos.nih.gov/idg/api/v1/targets(10541)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/properties"},"_links":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10541)/publications"},"_namespace":null},{"id":10542,"version":3,"created":1554930746000,"modified":1555039451000,"deprecated":false,"name":"Glutamate decarboxylase 2","accession":"Q05329","gene":"GAD2","description":"Catalyzes the production of GABA.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.030467607966655,"antibodyCount":459,"monoclonalCount":94,"pubmedCount":null,"jensenScore":1065.419617,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":41.91403402548996,"pubTatorScore":2.8304306972549114,"self":"https://pharos.nih.gov/idg/api/v1/targets(10542)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/properties"},"_links":{"count":896,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/synonyms"},"_publications":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10542)/publications"},"_namespace":null},{"id":10543,"version":2,"created":1554930751000,"modified":1554930752000,"deprecated":false,"name":"Putative ankyrin repeat domain-containing protein 19","accession":"Q9H560","gene":"ANKRD19P","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.541598755655972,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10543)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/properties"},"_links":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10543)/publications"},"_namespace":null},{"id":10544,"version":2,"created":1554930752000,"modified":1554930755000,"deprecated":false,"name":"Kinesin-like protein KIFC2","accession":"Q96AC6","gene":"KIFC2","description":"May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6859548818274589,"antibodyCount":58,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.335713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.758096870567474,"pubTatorScore":-0.062148240821651324,"self":"https://pharos.nih.gov/idg/api/v1/targets(10544)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10544)/publications"},"_namespace":null},{"id":10545,"version":2,"created":1554930756000,"modified":1554930760000,"deprecated":false,"name":"Zinc finger SWIM domain-containing protein 8","accession":"A7E2V4","gene":"ZSWIM8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.35627651704726,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10545)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/properties"},"_links":{"count":1005,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10545)/publications"},"_namespace":null},{"id":10546,"version":3,"created":1554930761000,"modified":1555039452000,"deprecated":false,"name":"Fermitin family homolog 2","accession":"Q96AC1","gene":"FERMT2","description":"Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8894318366281535,"antibodyCount":180,"monoclonalCount":75,"pubmedCount":null,"jensenScore":85.695755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.23071466957254,"pubTatorScore":1.8038958250426835,"self":"https://pharos.nih.gov/idg/api/v1/targets(10546)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/properties"},"_links":{"count":1178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10546)/publications"},"_namespace":null},{"id":10547,"version":3,"created":1554930769000,"modified":1555039454000,"deprecated":false,"name":"AP-3 complex subunit sigma-1","accession":"Q92572","gene":"AP3S1","description":"Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.635148516810052,"antibodyCount":117,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.428953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":39.07409712281573,"pubTatorScore":0.729704648286999,"self":"https://pharos.nih.gov/idg/api/v1/targets(10547)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/links"},"_synonyms":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10547)/publications"},"_namespace":null},{"id":10548,"version":2,"created":1554930775000,"modified":1554930781000,"deprecated":false,"name":"Nuclear receptor subfamily 4 group A member 3","accession":"Q92570","gene":"NR4A3","description":"Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity).","idgFamily":"Nuclear Receptor","idgTDL":"Tbio","novelty":-2.0275199128283115,"antibodyCount":289,"monoclonalCount":88,"pubmedCount":null,"jensenScore":112.675982,"patentCount":152037,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.7545292369438,"pubTatorScore":2.313174867192345,"self":"https://pharos.nih.gov/idg/api/v1/targets(10548)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/synonyms"},"_publications":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10548)/publications"},"_namespace":null},{"id":10549,"version":2,"created":1554930782000,"modified":1554930787000,"deprecated":false,"name":"PHD finger protein 3","accession":"Q92576","gene":"PHF3","description":null,"idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.0238075328990646,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.248085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.717555937214485,"pubTatorScore":0.9704243820440289,"self":"https://pharos.nih.gov/idg/api/v1/targets(10549)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/properties"},"_links":{"count":1008,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10549)/publications"},"_namespace":null},{"id":10550,"version":3,"created":1554930788000,"modified":1555039455000,"deprecated":false,"name":"UBX domain-containing protein 4","accession":"Q92575","gene":"UBXN4","description":"Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.402261386797625,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.404196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.60395057822903,"pubTatorScore":0.4191291422964272,"self":"https://pharos.nih.gov/idg/api/v1/targets(10550)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/properties"},"_links":{"count":1106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10550)/publications"},"_namespace":null},{"id":10551,"version":2,"created":1554930796000,"modified":1554930799000,"deprecated":false,"name":"Tumor suppressor candidate gene 1 protein","accession":"Q2TAM9","gene":"TUSC1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7359535691415405,"antibodyCount":92,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.2939,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.556242369825544,"pubTatorScore":0.8672710386167818,"self":"https://pharos.nih.gov/idg/api/v1/targets(10551)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":258,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10551)/publications"},"_namespace":null},{"id":10552,"version":3,"created":1554930800000,"modified":1555039456000,"deprecated":false,"name":"Hamartin","accession":"Q92574","gene":"TSC1","description":"In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2545051770132143,"antibodyCount":1622,"monoclonalCount":171,"pubmedCount":null,"jensenScore":173.923533,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":54.80535582373198,"pubTatorScore":2.842958924246618,"self":"https://pharos.nih.gov/idg/api/v1/targets(10552)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":708,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/properties"},"_links":{"count":1413,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/synonyms"},"_publications":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(10552)/publications"},"_namespace":null},{"id":10553,"version":2,"created":1554930812000,"modified":1554930819000,"deprecated":false,"name":"Splicing factor 3B subunit 1","accession":"O75533","gene":"SF3B1","description":"Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6272808960568457,"antibodyCount":189,"monoclonalCount":15,"pubmedCount":null,"jensenScore":40.430011,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.298557121404656,"pubTatorScore":2.1968298906855708,"self":"https://pharos.nih.gov/idg/api/v1/targets(10553)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":553,"href":"https://pharos.nih.gov/idg/api/v1/targets(10553)/properties"},"_links":{"count":1356,"href":"https://pharos.nih.gov/idg/api/v1/targets(10553)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10553)/synonyms"},"_publications":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10553)/publications"},"_namespace":null},{"id":10554,"version":2,"created":1554930820000,"modified":1554930828000,"deprecated":false,"name":"Cold shock domain-containing protein E1","accession":"O75534","gene":"CSDE1","description":"RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.38700794369305,"antibodyCount":135,"monoclonalCount":3,"pubmedCount":null,"jensenScore":28.034995,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.31896962457447,"pubTatorScore":1.423124434777987,"self":"https://pharos.nih.gov/idg/api/v1/targets(10554)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(10554)/properties"},"_links":{"count":1263,"href":"https://pharos.nih.gov/idg/api/v1/targets(10554)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10554)/synonyms"},"_publications":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(10554)/publications"},"_namespace":null},{"id":10555,"version":2,"created":1554930829000,"modified":1554930834000,"deprecated":false,"name":"Barrier-to-autointegration factor","accession":"O75531","gene":"BANF1","description":"(Microbial infection) In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.890077393325429,"antibodyCount":207,"monoclonalCount":36,"pubmedCount":null,"jensenScore":741.359475,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.944063692072206,"pubTatorScore":2.432772371413912,"self":"https://pharos.nih.gov/idg/api/v1/targets(10555)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":472,"href":"https://pharos.nih.gov/idg/api/v1/targets(10555)/properties"},"_links":{"count":1262,"href":"https://pharos.nih.gov/idg/api/v1/targets(10555)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(10555)/synonyms"},"_publications":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10555)/publications"},"_namespace":null},{"id":10556,"version":3,"created":1554930836000,"modified":1555039459000,"deprecated":false,"name":"Polycomb protein EED","accession":"O75530","gene":"EED","description":"Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.234502067837765,"antibodyCount":278,"monoclonalCount":69,"pubmedCount":null,"jensenScore":157.413836,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":47.81200470404462,"pubTatorScore":1.8714332383712875,"self":"https://pharos.nih.gov/idg/api/v1/targets(10556)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(10556)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(10556)/links"},"_synonyms":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10556)/synonyms"},"_publications":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10556)/publications"},"_namespace":null},{"id":10557,"version":2,"created":1554930841000,"modified":1554930846000,"deprecated":false,"name":"Alpha-1,3/1,6-mannosyltransferase ALG2","accession":"Q9H553","gene":"ALG2","description":"Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.270161037926574,"antibodyCount":151,"monoclonalCount":28,"pubmedCount":null,"jensenScore":16.098592,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.68215101699239,"pubTatorScore":1.8050488616181364,"self":"https://pharos.nih.gov/idg/api/v1/targets(10557)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(10557)/properties"},"_links":{"count":1009,"href":"https://pharos.nih.gov/idg/api/v1/targets(10557)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10557)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10557)/publications"},"_namespace":null},{"id":10558,"version":2,"created":1554930847000,"modified":1554930851000,"deprecated":false,"name":"Zinc finger and SCAN domain-containing protein 16","accession":"Q9H4T2","gene":"ZSCAN16","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.6213651552092387,"antibodyCount":147,"monoclonalCount":7,"pubmedCount":null,"jensenScore":4.157576,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.7721182172875,"pubTatorScore":0.340624339396125,"self":"https://pharos.nih.gov/idg/api/v1/targets(10558)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(10558)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(10558)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10558)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10558)/publications"},"_namespace":null},{"id":10559,"version":3,"created":1554930851000,"modified":1555039460000,"deprecated":false,"name":"Isochorismatase domain-containing protein 2","accession":"Q96AB3","gene":"ISOC2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.15970084431516016,"antibodyCount":70,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":26.97418628916057,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(10559)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10559)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(10559)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10559)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10559)/publications"},"_namespace":null},{"id":10560,"version":2,"created":1554930855000,"modified":1554930861000,"deprecated":false,"name":"DNA-directed RNA polymerase II subunit RPB1","accession":"P24928","gene":"POLR2A","description":"(Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4002795460006996,"antibodyCount":437,"monoclonalCount":221,"pubmedCount":null,"jensenScore":236.439567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":54.783860355839,"pubTatorScore":2.116310044008418,"self":"https://pharos.nih.gov/idg/api/v1/targets(10560)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":800,"href":"https://pharos.nih.gov/idg/api/v1/targets(10560)/properties"},"_links":{"count":1220,"href":"https://pharos.nih.gov/idg/api/v1/targets(10560)/links"},"_synonyms":{"count":216,"href":"https://pharos.nih.gov/idg/api/v1/targets(10560)/synonyms"},"_publications":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(10560)/publications"},"_namespace":null},{"id":10561,"version":3,"created":1554930863000,"modified":1555039463000,"deprecated":false,"name":"Lysozyme-like protein 2","accession":"Q7Z4W2","gene":"LYZL2","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.1945746643877823,"antibodyCount":25,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.531506,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":54,"knowledgeAvailability":10.138391225971102,"pubTatorScore":0.5185139398778874,"self":"https://pharos.nih.gov/idg/api/v1/targets(10561)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10561)/properties"},"_links":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10561)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10561)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10561)/publications"},"_namespace":null},{"id":10562,"version":3,"created":1554930864000,"modified":1555039464000,"deprecated":false,"name":"Protein N-terminal asparagine amidohydrolase","accession":"Q96AB6","gene":"NTAN1","description":"Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.2284154585160483,"antibodyCount":67,"monoclonalCount":10,"pubmedCount":null,"jensenScore":166.367706,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.80373394587825,"pubTatorScore":1.8170268941116179,"self":"https://pharos.nih.gov/idg/api/v1/targets(10562)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":244,"href":"https://pharos.nih.gov/idg/api/v1/targets(10562)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(10562)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10562)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10562)/publications"},"_namespace":null},{"id":10563,"version":2,"created":1554930868000,"modified":1554930872000,"deprecated":false,"name":"L-xylulose reductase","accession":"Q7Z4W1","gene":"DCXR","description":"Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.1374452706631857,"antibodyCount":238,"monoclonalCount":65,"pubmedCount":null,"jensenScore":1296.363854,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.36199727615114,"pubTatorScore":1.6334544165310507,"self":"https://pharos.nih.gov/idg/api/v1/targets(10563)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(10563)/properties"},"_links":{"count":1110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10563)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10563)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(10563)/publications"},"_namespace":null},{"id":10564,"version":2,"created":1554930873000,"modified":1554930876000,"deprecated":false,"name":"Galectin-10","accession":"Q05315","gene":"CLC","description":"Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.193514091904713,"antibodyCount":193,"monoclonalCount":34,"pubmedCount":null,"jensenScore":144.175864,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.995535112805545,"pubTatorScore":1.281412152372219,"self":"https://pharos.nih.gov/idg/api/v1/targets(10564)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(10564)/properties"},"_links":{"count":592,"href":"https://pharos.nih.gov/idg/api/v1/targets(10564)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10564)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10564)/publications"},"_namespace":null},{"id":10565,"version":3,"created":1554930877000,"modified":1555039465000,"deprecated":false,"name":"Polyphosphoinositide phosphatase","accession":"Q92562","gene":"FIG4","description":"The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4008289686069464,"antibodyCount":177,"monoclonalCount":93,"pubmedCount":null,"jensenScore":231.833154,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":45.76401495403779,"pubTatorScore":1.5394101134768858,"self":"https://pharos.nih.gov/idg/api/v1/targets(10565)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(10565)/properties"},"_links":{"count":1233,"href":"https://pharos.nih.gov/idg/api/v1/targets(10565)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10565)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10565)/publications"},"_namespace":null},{"id":10566,"version":2,"created":1554930885000,"modified":1554930885000,"deprecated":false,"name":"Keratin-associated protein 19-3","accession":"Q7Z4W3","gene":"KRTAP19-3","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.07918124604762482,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.666666,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.130395299732975,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10566)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10566)/properties"},"_links":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10566)/links"},"_synonyms":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(10566)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10566)/publications"},"_namespace":null},{"id":10567,"version":3,"created":1554930885000,"modified":1555039466000,"deprecated":false,"name":"Phytanoyl-CoA hydroxylase-interacting protein","accession":"Q92561","gene":"PHYHIP","description":"Its interaction with PHYH suggests a role in the development of the central system.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4687691742747739,"antibodyCount":91,"monoclonalCount":3,"pubmedCount":null,"jensenScore":3.26164,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":20.740953784376384,"pubTatorScore":0.37740169792321443,"self":"https://pharos.nih.gov/idg/api/v1/targets(10567)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":257,"href":"https://pharos.nih.gov/idg/api/v1/targets(10567)/properties"},"_links":{"count":911,"href":"https://pharos.nih.gov/idg/api/v1/targets(10567)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10567)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10567)/publications"},"_namespace":null},{"id":10568,"version":3,"created":1554930889000,"modified":1555039468000,"deprecated":false,"name":"Ubiquitin carboxyl-terminal hydrolase BAP1","accession":"Q92560","gene":"BAP1","description":"Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1381938667491216,"antibodyCount":304,"monoclonalCount":93,"pubmedCount":null,"jensenScore":132.306201,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":39.55902215102554,"pubTatorScore":2.3542858391094867,"self":"https://pharos.nih.gov/idg/api/v1/targets(10568)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":584,"href":"https://pharos.nih.gov/idg/api/v1/targets(10568)/properties"},"_links":{"count":1246,"href":"https://pharos.nih.gov/idg/api/v1/targets(10568)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10568)/synonyms"},"_publications":{"count":185,"href":"https://pharos.nih.gov/idg/api/v1/targets(10568)/publications"},"_namespace":null},{"id":10569,"version":3,"created":1554930897000,"modified":1555039470000,"deprecated":false,"name":"Smoothelin-like protein 2","accession":"Q2TAL5","gene":"SMTNL2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0036342840760347464,"antibodyCount":62,"monoclonalCount":4,"pubmedCount":null,"jensenScore":1.172619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":21.284040426520658,"pubTatorScore":-0.06214773971253742,"self":"https://pharos.nih.gov/idg/api/v1/targets(10569)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(10569)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(10569)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10569)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10569)/publications"},"_namespace":null},{"id":10570,"version":3,"created":1554930900000,"modified":1555039473000,"deprecated":false,"name":"Brorin","accession":"Q2TAL6","gene":"VWC2","description":"BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4128470521240152,"antibodyCount":41,"monoclonalCount":9,"pubmedCount":null,"jensenScore":2.621889,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":18.504306679097088,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(10570)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":221,"href":"https://pharos.nih.gov/idg/api/v1/targets(10570)/properties"},"_links":{"count":739,"href":"https://pharos.nih.gov/idg/api/v1/targets(10570)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10570)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10570)/publications"},"_namespace":null},{"id":10571,"version":3,"created":1554930903000,"modified":1555039474000,"deprecated":false,"name":"Rap guanine nucleotide exchange factor 5","accession":"Q92565","gene":"RAPGEF5","description":"Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6267723281655413,"antibodyCount":179,"monoclonalCount":4,"pubmedCount":null,"jensenScore":41.016331,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":37.41530215835445,"pubTatorScore":2.283974801248381,"self":"https://pharos.nih.gov/idg/api/v1/targets(10571)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(10571)/properties"},"_links":{"count":893,"href":"https://pharos.nih.gov/idg/api/v1/targets(10571)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10571)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10571)/publications"},"_namespace":null},{"id":10572,"version":2,"created":1554930909000,"modified":1554930913000,"deprecated":false,"name":"Glutamine-rich protein 1","accession":"Q2TAL8","gene":"QRICH1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.045757490560675115,"antibodyCount":18,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.157895,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.764428156028558,"pubTatorScore":-0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(10572)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(10572)/properties"},"_links":{"count":1091,"href":"https://pharos.nih.gov/idg/api/v1/targets(10572)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10572)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10572)/publications"},"_namespace":null},{"id":10573,"version":3,"created":1554930914000,"modified":1555039475000,"deprecated":false,"name":"DCN1-like protein 4","accession":"Q92564","gene":"DCUN1D4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":80,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":29.17613927967898,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10573)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10573)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(10573)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10573)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10573)/publications"},"_namespace":null},{"id":10574,"version":2,"created":1554930918000,"modified":1554930922000,"deprecated":false,"name":"Testican-2","accession":"Q92563","gene":"SPOCK2","description":"May participate in diverse steps of neurogenesis. Binds calcium.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8741913963990205,"antibodyCount":57,"monoclonalCount":5,"pubmedCount":null,"jensenScore":6.752348,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.39732190367604,"pubTatorScore":0.9724302972560789,"self":"https://pharos.nih.gov/idg/api/v1/targets(10574)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":374,"href":"https://pharos.nih.gov/idg/api/v1/targets(10574)/properties"},"_links":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(10574)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10574)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10574)/publications"},"_namespace":null},{"id":10575,"version":3,"created":1554930923000,"modified":1555039477000,"deprecated":false,"name":"Phosphatidylinositol 3-kinase regulatory subunit gamma","accession":"Q92569","gene":"PIK3R3","description":"Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.572139805770795,"antibodyCount":155,"monoclonalCount":14,"pubmedCount":null,"jensenScore":38.195079,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":45.60770602183699,"pubTatorScore":1.6153564082615461,"self":"https://pharos.nih.gov/idg/api/v1/targets(10575)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":547,"href":"https://pharos.nih.gov/idg/api/v1/targets(10575)/properties"},"_links":{"count":1063,"href":"https://pharos.nih.gov/idg/api/v1/targets(10575)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10575)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(10575)/publications"},"_namespace":null},{"id":10576,"version":2,"created":1554930929000,"modified":1554930932000,"deprecated":false,"name":"Protein FAM168A","accession":"Q92567","gene":"FAM168A","description":"In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9066941187885399,"antibodyCount":35,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.627045,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.444671443846016,"pubTatorScore":1.0239380211982303,"self":"https://pharos.nih.gov/idg/api/v1/targets(10576)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10576)/properties"},"_links":{"count":859,"href":"https://pharos.nih.gov/idg/api/v1/targets(10576)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10576)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10576)/publications"},"_namespace":null},{"id":10577,"version":3,"created":1554930933000,"modified":1555039479000,"deprecated":false,"name":"Transcriptional adapter 3","accession":"O75528","gene":"TADA3","description":"Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5369360954869444,"antibodyCount":193,"monoclonalCount":20,"pubmedCount":null,"jensenScore":342.592306,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":22,"knowledgeAvailability":38.27653553179508,"pubTatorScore":1.513467234313975,"self":"https://pharos.nih.gov/idg/api/v1/targets(10577)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(10577)/properties"},"_links":{"count":1142,"href":"https://pharos.nih.gov/idg/api/v1/targets(10577)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10577)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(10577)/publications"},"_namespace":null},{"id":10578,"version":3,"created":1554930938000,"modified":1555039481000,"deprecated":false,"name":"TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L","accession":"O75529","gene":"TAF5L","description":"Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.10427111367520317,"antibodyCount":161,"monoclonalCount":22,"pubmedCount":null,"jensenScore":1.424337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.04706274378983,"pubTatorScore":0.43977103101115445,"self":"https://pharos.nih.gov/idg/api/v1/targets(10578)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(10578)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(10578)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10578)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10578)/publications"},"_namespace":null},{"id":10579,"version":3,"created":1554930942000,"modified":1555039482000,"deprecated":false,"name":"NMDA receptor synaptonuclear signaling and neuronal migration factor","accession":"Q6X4W1","gene":"NSMF","description":"Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7429868370842782,"antibodyCount":122,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.016612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.811981211792336,"pubTatorScore":1.6535174358481302,"self":"https://pharos.nih.gov/idg/api/v1/targets(10579)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(10579)/properties"},"_links":{"count":1130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10579)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10579)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10579)/publications"},"_namespace":null},{"id":10580,"version":2,"created":1554930948000,"modified":1554930950000,"deprecated":false,"name":"RNA-binding motif protein, X-linked-like-2","accession":"O75526","gene":"RBMXL2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5921238577737278,"antibodyCount":56,"monoclonalCount":27,"pubmedCount":null,"jensenScore":4.075907,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.82592954125613,"pubTatorScore":0.7811567126012166,"self":"https://pharos.nih.gov/idg/api/v1/targets(10580)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(10580)/properties"},"_links":{"count":656,"href":"https://pharos.nih.gov/idg/api/v1/targets(10580)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10580)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10580)/publications"},"_namespace":null},{"id":10581,"version":2,"created":1554930951000,"modified":1554930955000,"deprecated":false,"name":"KH domain-containing, RNA-binding, signal transduction-associated protein 3","accession":"O75525","gene":"KHDRBS3","description":"(Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3014818969545843,"antibodyCount":137,"monoclonalCount":2,"pubmedCount":null,"jensenScore":199.954801,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.96924954371432,"pubTatorScore":2.7398660678640727,"self":"https://pharos.nih.gov/idg/api/v1/targets(10581)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":391,"href":"https://pharos.nih.gov/idg/api/v1/targets(10581)/properties"},"_links":{"count":1035,"href":"https://pharos.nih.gov/idg/api/v1/targets(10581)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10581)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10581)/publications"},"_namespace":null},{"id":10582,"version":3,"created":1554930956000,"modified":1555039483000,"deprecated":false,"name":"Lymphotoxin-beta","accession":"Q06643","gene":"LTB","description":"Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1538491423892285,"antibodyCount":136,"monoclonalCount":28,"pubmedCount":null,"jensenScore":132.024113,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":35.37289908613113,"pubTatorScore":2.0625789347557704,"self":"https://pharos.nih.gov/idg/api/v1/targets(10582)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":278,"href":"https://pharos.nih.gov/idg/api/v1/targets(10582)/properties"},"_links":{"count":745,"href":"https://pharos.nih.gov/idg/api/v1/targets(10582)/links"},"_synonyms":{"count":133,"href":"https://pharos.nih.gov/idg/api/v1/targets(10582)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10582)/publications"},"_namespace":null},{"id":10583,"version":3,"created":1554930960000,"modified":1555039485000,"deprecated":false,"name":"Myosin-7B","accession":"A7E2Y1","gene":"MYH7B","description":"Involved in muscle contraction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.186549052395936,"antibodyCount":17,"monoclonalCount":1,"pubmedCount":null,"jensenScore":12.101583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":33.18989280798812,"pubTatorScore":0.749289659054747,"self":"https://pharos.nih.gov/idg/api/v1/targets(10583)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10583)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(10583)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10583)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10583)/publications"},"_namespace":null},{"id":10584,"version":2,"created":1554930964000,"modified":1554930968000,"deprecated":false,"name":"Enoyl-CoA delta isomerase 2, mitochondrial","accession":"O75521","gene":"ECI2","description":"Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.427829757189861,"antibodyCount":174,"monoclonalCount":21,"pubmedCount":null,"jensenScore":24.047873,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.04726540610274,"pubTatorScore":1.2730012720637376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10584)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(10584)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10584)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10584)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10584)/publications"},"_namespace":null},{"id":10585,"version":2,"created":1554930969000,"modified":1554930971000,"deprecated":false,"name":"Uncharacterized protein C6orf201","accession":"Q7Z4U5","gene":"C6orf201","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10585)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10585)/properties"},"_links":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(10585)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10585)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10585)/publications"},"_namespace":null},{"id":10586,"version":3,"created":1554930972000,"modified":1555039486000,"deprecated":false,"name":"Kazrin","accession":"Q674X7","gene":"KAZN","description":"Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2470885868723436,"antibodyCount":89,"monoclonalCount":3,"pubmedCount":null,"jensenScore":18.586265,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":39.55637972703037,"pubTatorScore":0.7020006824595065,"self":"https://pharos.nih.gov/idg/api/v1/targets(10586)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(10586)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(10586)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10586)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10586)/publications"},"_namespace":null},{"id":10587,"version":2,"created":1554930977000,"modified":1554930998000,"deprecated":false,"name":"1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial","accession":"Q07973","gene":"CYP24A1","description":"Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.9146023779830306,"antibodyCount":228,"monoclonalCount":27,"pubmedCount":null,"jensenScore":825.906772,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.57737992385759,"pubTatorScore":2.619805388321727,"self":"https://pharos.nih.gov/idg/api/v1/targets(10587)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":412,"href":"https://pharos.nih.gov/idg/api/v1/targets(10587)/properties"},"_links":{"count":925,"href":"https://pharos.nih.gov/idg/api/v1/targets(10587)/links"},"_synonyms":{"count":123,"href":"https://pharos.nih.gov/idg/api/v1/targets(10587)/synonyms"},"_publications":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(10587)/publications"},"_namespace":null},{"id":10588,"version":2,"created":1554930999000,"modified":1554931004000,"deprecated":false,"name":"BRCA1-associated protein","accession":"Q7Z569","gene":"BRAP","description":"Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2752702431320095,"antibodyCount":113,"monoclonalCount":11,"pubmedCount":null,"jensenScore":19.865956,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.75482682558988,"pubTatorScore":1.6015167727790593,"self":"https://pharos.nih.gov/idg/api/v1/targets(10588)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(10588)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(10588)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10588)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10588)/publications"},"_namespace":null},{"id":10589,"version":2,"created":1554931005000,"modified":1554931007000,"deprecated":false,"name":"GS homeobox 1","accession":"Q9H4S2","gene":"GSX1","description":"Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-1.6675591161219578,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":46.656713,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.949056614953413,"pubTatorScore":1.281309658893963,"self":"https://pharos.nih.gov/idg/api/v1/targets(10589)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10589)/properties"},"_links":{"count":341,"href":"https://pharos.nih.gov/idg/api/v1/targets(10589)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10589)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10589)/publications"},"_namespace":null},{"id":10590,"version":2,"created":1554931008000,"modified":1554931012000,"deprecated":false,"name":"Protein RFT1 homolog","accession":"Q96AA3","gene":"RFT1","description":"May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":78,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.925038218689096,"pubTatorScore":1.2695129675670813,"self":"https://pharos.nih.gov/idg/api/v1/targets(10590)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(10590)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(10590)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10590)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10590)/publications"},"_namespace":null},{"id":10591,"version":2,"created":1554931013000,"modified":1554931018000,"deprecated":false,"name":"Zinc finger protein 438","accession":"Q7Z4V0","gene":"ZNF438","description":"Isoform 1 acts as a transcriptional repressor.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.12493873660829995,"antibodyCount":6,"monoclonalCount":1,"pubmedCount":null,"jensenScore":1.363636,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.61445100634956,"pubTatorScore":0.3679767232525211,"self":"https://pharos.nih.gov/idg/api/v1/targets(10591)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(10591)/properties"},"_links":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(10591)/links"},"_synonyms":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(10591)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10591)/publications"},"_namespace":null},{"id":10592,"version":2,"created":1554931019000,"modified":1554931024000,"deprecated":false,"name":"Zinc finger protein 804A","accession":"Q7Z570","gene":"ZNF804A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0224121901088288,"antibodyCount":24,"monoclonalCount":2,"pubmedCount":null,"jensenScore":106.149757,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.241587349441993,"pubTatorScore":2.172202959752215,"self":"https://pharos.nih.gov/idg/api/v1/targets(10592)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":313,"href":"https://pharos.nih.gov/idg/api/v1/targets(10592)/properties"},"_links":{"count":887,"href":"https://pharos.nih.gov/idg/api/v1/targets(10592)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10592)/synonyms"},"_publications":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10592)/publications"},"_namespace":null},{"id":10593,"version":2,"created":1554931026000,"modified":1554931029000,"deprecated":false,"name":"Inositol hexakisphosphate kinase 1","accession":"Q92551","gene":"IP6K1","description":"Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.4998358678591872,"antibodyCount":148,"monoclonalCount":22,"pubmedCount":null,"jensenScore":35.113362,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.64008741069241,"pubTatorScore":1.461148218730696,"self":"https://pharos.nih.gov/idg/api/v1/targets(10593)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(10593)/properties"},"_links":{"count":996,"href":"https://pharos.nih.gov/idg/api/v1/targets(10593)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10593)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10593)/publications"},"_namespace":null},{"id":10594,"version":2,"created":1554931030000,"modified":1554931032000,"deprecated":false,"name":"Spermatogenesis-associated protein 21","accession":"Q7Z572","gene":"SPATA21","description":"Involved in the differentiation of haploid spermatids.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.40576534695952005,"antibodyCount":54,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.308824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.575425835513355,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(10594)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":182,"href":"https://pharos.nih.gov/idg/api/v1/targets(10594)/properties"},"_links":{"count":720,"href":"https://pharos.nih.gov/idg/api/v1/targets(10594)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10594)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10594)/publications"},"_namespace":null},{"id":10595,"version":3,"created":1554931033000,"modified":1555039489000,"deprecated":false,"name":"Hepatoma-derived growth factor-related protein 2","accession":"Q7Z4V5","gene":"HDGFL2","description":"Involved in cellular growth control, through the regulation of cyclin D1 expression.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-0.8129133675002178,"antibodyCount":96,"monoclonalCount":1,"pubmedCount":null,"jensenScore":5.499461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":52,"knowledgeAvailability":0.0,"pubTatorScore":2.0192548020624734,"self":"https://pharos.nih.gov/idg/api/v1/targets(10595)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(10595)/properties"},"_links":{"count":982,"href":"https://pharos.nih.gov/idg/api/v1/targets(10595)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10595)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10595)/publications"},"_namespace":null},{"id":10596,"version":3,"created":1554931036000,"modified":1555039491000,"deprecated":false,"name":"Argininosuccinate synthase","accession":"P00966","gene":"ASS1","description":"One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.308012829984247,"antibodyCount":322,"monoclonalCount":108,"pubmedCount":null,"jensenScore":186.051705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":48.083880753474226,"pubTatorScore":1.9874504446963923,"self":"https://pharos.nih.gov/idg/api/v1/targets(10596)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":465,"href":"https://pharos.nih.gov/idg/api/v1/targets(10596)/properties"},"_links":{"count":1145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10596)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10596)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10596)/publications"},"_namespace":null},{"id":10597,"version":3,"created":1554931044000,"modified":1555039492000,"deprecated":false,"name":"28S ribosomal protein S27, mitochondrial","accession":"Q92552","gene":"MRPS27","description":"RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3521825224543073,"antibodyCount":234,"monoclonalCount":127,"pubmedCount":null,"jensenScore":2.594445,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":33.71739575237482,"pubTatorScore":0.35561566659262284,"self":"https://pharos.nih.gov/idg/api/v1/targets(10597)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":360,"href":"https://pharos.nih.gov/idg/api/v1/targets(10597)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(10597)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10597)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10597)/publications"},"_namespace":null},{"id":10598,"version":2,"created":1554931049000,"modified":1554931055000,"deprecated":false,"name":"Pre-mRNA 3'-end-processing factor FIP1","accession":"Q6UN15","gene":"FIP1L1","description":"Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1912989494254935,"antibodyCount":110,"monoclonalCount":20,"pubmedCount":null,"jensenScore":159.746612,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.79065749292018,"pubTatorScore":2.206586732438359,"self":"https://pharos.nih.gov/idg/api/v1/targets(10598)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":430,"href":"https://pharos.nih.gov/idg/api/v1/targets(10598)/properties"},"_links":{"count":1180,"href":"https://pharos.nih.gov/idg/api/v1/targets(10598)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10598)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10598)/publications"},"_namespace":null},{"id":10599,"version":2,"created":1554931056000,"modified":1554931062000,"deprecated":false,"name":"Wiskott-Aldrich syndrome protein family member 1","accession":"Q92558","gene":"WASF1","description":"Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0752143323744066,"antibodyCount":216,"monoclonalCount":55,"pubmedCount":null,"jensenScore":1145.855488,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.00934798185031,"pubTatorScore":2.7795684321864935,"self":"https://pharos.nih.gov/idg/api/v1/targets(10599)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(10599)/properties"},"_links":{"count":1083,"href":"https://pharos.nih.gov/idg/api/v1/targets(10599)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10599)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10599)/publications"},"_namespace":null},{"id":10600,"version":2,"created":1554931063000,"modified":1554931069000,"deprecated":false,"name":"Janus kinase and microtubule-interacting protein 2","accession":"Q96AA8","gene":"JAKMIP2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.16914240220245688,"antibodyCount":165,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.611112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.081191202589505,"pubTatorScore":0.3222192947339193,"self":"https://pharos.nih.gov/idg/api/v1/targets(10600)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(10600)/properties"},"_links":{"count":892,"href":"https://pharos.nih.gov/idg/api/v1/targets(10600)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10600)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10600)/publications"},"_namespace":null},{"id":10601,"version":3,"created":1554931070000,"modified":1555039494000,"deprecated":false,"name":"Engulfment and cell motility protein 1","accession":"Q92556","gene":"ELMO1","description":"Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.622417302110219,"antibodyCount":178,"monoclonalCount":5,"pubmedCount":null,"jensenScore":45.367163,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":45.38415052157294,"pubTatorScore":1.5581696151178883,"self":"https://pharos.nih.gov/idg/api/v1/targets(10601)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(10601)/properties"},"_links":{"count":1127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10601)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(10601)/synonyms"},"_publications":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10601)/publications"},"_namespace":null},{"id":10602,"version":2,"created":1554931078000,"modified":1554931082000,"deprecated":false,"name":"Centrosomal protein of 68 kDa","accession":"Q76N32","gene":"CEP68","description":"Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.21748394139099217,"antibodyCount":107,"monoclonalCount":43,"pubmedCount":null,"jensenScore":1.516667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.091980077845506,"pubTatorScore":0.9315565673878172,"self":"https://pharos.nih.gov/idg/api/v1/targets(10602)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(10602)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(10602)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10602)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10602)/publications"},"_namespace":null},{"id":10603,"version":2,"created":1554931083000,"modified":1554931083000,"deprecated":false,"name":"Putative nuclear receptor corepressor 1-like protein NCOR1P1","accession":"Q9H4R4","gene":"NCOR1P1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.227376052516799,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10603)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10603)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10603)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10603)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10603)/publications"},"_namespace":null},{"id":10604,"version":2,"created":1554931083000,"modified":1554931086000,"deprecated":false,"name":"Cilia- and flagella-associated protein 91","accession":"Q7Z4T9","gene":"MAATS1","description":"Isoform 4: May play a role in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2512325300520977,"antibodyCount":75,"monoclonalCount":45,"pubmedCount":null,"jensenScore":1.933333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.04221046401744,"pubTatorScore":0.4573772470232607,"self":"https://pharos.nih.gov/idg/api/v1/targets(10604)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":191,"href":"https://pharos.nih.gov/idg/api/v1/targets(10604)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(10604)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10604)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10604)/publications"},"_namespace":null},{"id":10605,"version":2,"created":1554931087000,"modified":1554931090000,"deprecated":false,"name":"Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5","accession":"Q7Z4T8","gene":"GALNTL5","description":"Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4051185965563696,"antibodyCount":79,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.53482,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.824577952298313,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10605)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10605)/properties"},"_links":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(10605)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10605)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10605)/publications"},"_namespace":null},{"id":10606,"version":2,"created":1554931091000,"modified":1554931095000,"deprecated":false,"name":"Rho GTPase-activating protein 1","accession":"Q07960","gene":"ARHGAP1","description":"GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.117448710784305,"antibodyCount":149,"monoclonalCount":3,"pubmedCount":null,"jensenScore":99.341978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.78734204137135,"pubTatorScore":2.0075378324841835,"self":"https://pharos.nih.gov/idg/api/v1/targets(10606)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":451,"href":"https://pharos.nih.gov/idg/api/v1/targets(10606)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10606)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10606)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10606)/publications"},"_namespace":null},{"id":10607,"version":3,"created":1554931096000,"modified":1555039495000,"deprecated":false,"name":"Protein PRRC2B","accession":"Q5JSZ5","gene":"PRRC2B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4631105340726409,"antibodyCount":22,"monoclonalCount":2,"pubmedCount":null,"jensenScore":2.365642,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":34.26334219391198,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10607)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(10607)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10607)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10607)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10607)/publications"},"_namespace":null},{"id":10608,"version":2,"created":1554931100000,"modified":1554931108000,"deprecated":false,"name":"Protein SMG7","accession":"Q92540","gene":"SMG7","description":"Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1732851172675913,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.171224,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.03593512657382,"pubTatorScore":0.9038218077011729,"self":"https://pharos.nih.gov/idg/api/v1/targets(10608)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(10608)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(10608)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10608)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10608)/publications"},"_namespace":null},{"id":10609,"version":2,"created":1554931109000,"modified":1554931110000,"deprecated":false,"name":"Cytochrome P450 2F1","accession":"P24903","gene":"CYP2F1","description":"May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.533840575133491,"antibodyCount":68,"monoclonalCount":1,"pubmedCount":null,"jensenScore":31.260559,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.06053601960187,"pubTatorScore":1.4839437997954772,"self":"https://pharos.nih.gov/idg/api/v1/targets(10609)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(10609)/properties"},"_links":{"count":415,"href":"https://pharos.nih.gov/idg/api/v1/targets(10609)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10609)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10609)/publications"},"_namespace":null},{"id":10610,"version":3,"created":1554931111000,"modified":1555039498000,"deprecated":false,"name":"Prolow-density lipoprotein receptor-related protein 1","accession":"Q07954","gene":"LRP1","description":"(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5201167479183586,"antibodyCount":711,"monoclonalCount":382,"pubmedCount":null,"jensenScore":357.112463,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":46,"knowledgeAvailability":50.23201470191158,"pubTatorScore":2.9260025667383625,"self":"https://pharos.nih.gov/idg/api/v1/targets(10610)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":862,"href":"https://pharos.nih.gov/idg/api/v1/targets(10610)/properties"},"_links":{"count":1428,"href":"https://pharos.nih.gov/idg/api/v1/targets(10610)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(10610)/synonyms"},"_publications":{"count":379,"href":"https://pharos.nih.gov/idg/api/v1/targets(10610)/publications"},"_namespace":null},{"id":10611,"version":2,"created":1554931121000,"modified":1554931128000,"deprecated":false,"name":"Serine/arginine-rich splicing factor 1","accession":"Q07955","gene":"SRSF1","description":"Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9106389800565866,"antibodyCount":223,"monoclonalCount":45,"pubmedCount":null,"jensenScore":772.567087,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":52.001874621604294,"pubTatorScore":2.7678525078210447,"self":"https://pharos.nih.gov/idg/api/v1/targets(10611)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":634,"href":"https://pharos.nih.gov/idg/api/v1/targets(10611)/properties"},"_links":{"count":1300,"href":"https://pharos.nih.gov/idg/api/v1/targets(10611)/links"},"_synonyms":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10611)/synonyms"},"_publications":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10611)/publications"},"_namespace":null},{"id":10612,"version":2,"created":1554931130000,"modified":1554931134000,"deprecated":false,"name":"Transmembrane 9 superfamily member 4","accession":"Q92544","gene":"TM9SF4","description":"Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.831443151241423,"antibodyCount":76,"monoclonalCount":1,"pubmedCount":null,"jensenScore":8.577451,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.42359614033769,"pubTatorScore":0.7596678446896304,"self":"https://pharos.nih.gov/idg/api/v1/targets(10612)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":381,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/properties"},"_links":{"count":1063,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10612)/publications"},"_namespace":null},{"id":10613,"version":2,"created":1554931135000,"modified":1554931140000,"deprecated":false,"name":"Sorting nexin-19","accession":"Q92543","gene":"SNX19","description":"Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5426871444244832,"antibodyCount":70,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.058025,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.28204057415145,"pubTatorScore":0.5546236069384671,"self":"https://pharos.nih.gov/idg/api/v1/targets(10613)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10613)/properties"},"_links":{"count":899,"href":"https://pharos.nih.gov/idg/api/v1/targets(10613)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10613)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10613)/publications"},"_namespace":null},{"id":10614,"version":3,"created":1554931141000,"modified":1555039501000,"deprecated":false,"name":"Nicastrin","accession":"Q92542","gene":"NCSTN","description":"Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1521972997458567,"antibodyCount":357,"monoclonalCount":85,"pubmedCount":null,"jensenScore":133.237088,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":46.74426044835637,"pubTatorScore":2.0601357678578647,"self":"https://pharos.nih.gov/idg/api/v1/targets(10614)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":595,"href":"https://pharos.nih.gov/idg/api/v1/targets(10614)/properties"},"_links":{"count":1264,"href":"https://pharos.nih.gov/idg/api/v1/targets(10614)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10614)/synonyms"},"_publications":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10614)/publications"},"_namespace":null},{"id":10615,"version":2,"created":1554931149000,"modified":1554931153000,"deprecated":false,"name":"RNA polymerase-associated protein RTF1 homolog","accession":"Q92541","gene":"RTF1","description":"Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4468221215839163,"antibodyCount":157,"monoclonalCount":5,"pubmedCount":null,"jensenScore":29.055308,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.47697646302069,"pubTatorScore":0.7639694756656794,"self":"https://pharos.nih.gov/idg/api/v1/targets(10615)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":403,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10615)/publications"},"_namespace":null},{"id":10616,"version":2,"created":1554931155000,"modified":1554931160000,"deprecated":false,"name":"DNA topoisomerase 2-binding protein 1","accession":"Q92547","gene":"TOPBP1","description":"Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0431187396858546,"antibodyCount":230,"monoclonalCount":22,"pubmedCount":null,"jensenScore":118.004437,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.62821714033587,"pubTatorScore":1.9600067145962696,"self":"https://pharos.nih.gov/idg/api/v1/targets(10616)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":502,"href":"https://pharos.nih.gov/idg/api/v1/targets(10616)/properties"},"_links":{"count":1160,"href":"https://pharos.nih.gov/idg/api/v1/targets(10616)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10616)/synonyms"},"_publications":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10616)/publications"},"_namespace":null},{"id":10617,"version":3,"created":1554931161000,"modified":1555039503000,"deprecated":false,"name":"RAB6A-GEF complex partner protein 2","accession":"Q92546","gene":"RGP1","description":"The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":87,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.11887631222796,"pubTatorScore":0.32614058937444856,"self":"https://pharos.nih.gov/idg/api/v1/targets(10617)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(10617)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(10617)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10617)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10617)/publications"},"_namespace":null},{"id":10618,"version":2,"created":1554931165000,"modified":1554931168000,"deprecated":false,"name":"Transmembrane protein 131","accession":"Q92545","gene":"TMEM131","description":"May play a role in the immune response to viral infection.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8283452035362056,"antibodyCount":16,"monoclonalCount":0,"pubmedCount":null,"jensenScore":66.402656,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.737035543869293,"pubTatorScore":1.3377919132538958,"self":"https://pharos.nih.gov/idg/api/v1/targets(10618)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(10618)/properties"},"_links":{"count":942,"href":"https://pharos.nih.gov/idg/api/v1/targets(10618)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10618)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10618)/publications"},"_namespace":null},{"id":10619,"version":2,"created":1554931169000,"modified":1554931172000,"deprecated":false,"name":"Heat shock factor-binding protein 1","accession":"O75506","gene":"HSBP1","description":"Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9796242549238089,"antibodyCount":68,"monoclonalCount":10,"pubmedCount":null,"jensenScore":10.13514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.650895252169235,"pubTatorScore":1.0534442881406232,"self":"https://pharos.nih.gov/idg/api/v1/targets(10619)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(10619)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(10619)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10619)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10619)/publications"},"_namespace":null},{"id":10620,"version":2,"created":1554931172000,"modified":1554931180000,"deprecated":false,"name":"HLA class I histocompatibility antigen, B-58 alpha chain","accession":"P10319","gene":"HLA-B","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8875247029897861,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1613.472112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.7801564385417628,"self":"https://pharos.nih.gov/idg/api/v1/targets(10620)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1933,"href":"https://pharos.nih.gov/idg/api/v1/targets(10620)/properties"},"_links":{"count":1507,"href":"https://pharos.nih.gov/idg/api/v1/targets(10620)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10620)/synonyms"},"_publications":{"count":1769,"href":"https://pharos.nih.gov/idg/api/v1/targets(10620)/publications"},"_namespace":null},{"id":10621,"version":3,"created":1554931187000,"modified":1555039505000,"deprecated":false,"name":"DNA-binding protein RFXANK","accession":"O14593","gene":"RFXANK","description":"Isoform 2 is not involved in the positive regulation of MHC class II genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8553541941844554,"antibodyCount":190,"monoclonalCount":91,"pubmedCount":null,"jensenScore":702.595575,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":34.819319040349164,"pubTatorScore":1.428681045606139,"self":"https://pharos.nih.gov/idg/api/v1/targets(10621)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10621)/properties"},"_links":{"count":1015,"href":"https://pharos.nih.gov/idg/api/v1/targets(10621)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10621)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10621)/publications"},"_namespace":null},{"id":10622,"version":2,"created":1554931192000,"modified":1554931197000,"deprecated":false,"name":"Ceroid-lipofuscinosis neuronal protein 5","accession":"O75503","gene":"CLN5","description":"Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.828233774397215,"antibodyCount":112,"monoclonalCount":3,"pubmedCount":null,"jensenScore":68.109097,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.04565654605769,"pubTatorScore":1.819656278256928,"self":"https://pharos.nih.gov/idg/api/v1/targets(10622)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(10622)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(10622)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10622)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10622)/publications"},"_namespace":null},{"id":10623,"version":2,"created":1554931198000,"modified":1554931203000,"deprecated":false,"name":"HLA class I histocompatibility antigen, A-69 alpha chain","accession":"P10316","gene":"HLA-A","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.416669710281058,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4123.756732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.457240582152559,"self":"https://pharos.nih.gov/idg/api/v1/targets(10623)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1413,"href":"https://pharos.nih.gov/idg/api/v1/targets(10623)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(10623)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10623)/synonyms"},"_publications":{"count":1226,"href":"https://pharos.nih.gov/idg/api/v1/targets(10623)/publications"},"_namespace":null},{"id":10624,"version":3,"created":1554931208000,"modified":1555039506000,"deprecated":false,"name":"E3 ubiquitin-protein ligase HECW1","accession":"Q76N89","gene":"HECW1","description":"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.17643579772447707,"antibodyCount":30,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.328614,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":30.395076286953337,"pubTatorScore":0.6266824320398772,"self":"https://pharos.nih.gov/idg/api/v1/targets(10624)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":380,"href":"https://pharos.nih.gov/idg/api/v1/targets(10624)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(10624)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(10624)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10624)/publications"},"_namespace":null},{"id":10625,"version":3,"created":1554931213000,"modified":1555039507000,"deprecated":false,"name":"Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2","accession":"O14595","gene":"CTDSP2","description":"Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7516968442282397,"antibodyCount":199,"monoclonalCount":51,"pubmedCount":null,"jensenScore":52.072826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":38.58018257147339,"pubTatorScore":0.8303747404059146,"self":"https://pharos.nih.gov/idg/api/v1/targets(10625)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10625)/properties"},"_links":{"count":888,"href":"https://pharos.nih.gov/idg/api/v1/targets(10625)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10625)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10625)/publications"},"_namespace":null},{"id":10626,"version":3,"created":1554931217000,"modified":1555039508000,"deprecated":false,"name":"Neurocan core protein","accession":"O14594","gene":"NCAN","description":"May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.197682010001477,"antibodyCount":127,"monoclonalCount":27,"pubmedCount":null,"jensenScore":158.359304,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.4506018146402,"pubTatorScore":1.413932283263182,"self":"https://pharos.nih.gov/idg/api/v1/targets(10626)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":252,"href":"https://pharos.nih.gov/idg/api/v1/targets(10626)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(10626)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10626)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10626)/publications"},"_namespace":null},{"id":10627,"version":4,"created":1554931223000,"modified":1555039509000,"deprecated":false,"name":"Sterol O-acyltransferase 1","accession":"P35610","gene":"SOAT1","description":"Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.1439378615243565,"antibodyCount":129,"monoclonalCount":3,"pubmedCount":null,"jensenScore":138.254513,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":44.79395553747715,"pubTatorScore":2.357628681499419,"self":"https://pharos.nih.gov/idg/api/v1/targets(10627)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(10627)/properties"},"_links":{"count":1116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10627)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10627)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10627)/publications"},"_namespace":null},{"id":10628,"version":3,"created":1554931275000,"modified":1555039513000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 3","accession":"P36941","gene":"LTBR","description":"Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.350926185917084,"antibodyCount":618,"monoclonalCount":348,"pubmedCount":null,"jensenScore":249.858181,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":57,"knowledgeAvailability":35.58657543436393,"pubTatorScore":2.1689382278053677,"self":"https://pharos.nih.gov/idg/api/v1/targets(10628)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(10628)/properties"},"_links":{"count":981,"href":"https://pharos.nih.gov/idg/api/v1/targets(10628)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10628)/synonyms"},"_publications":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10628)/publications"},"_namespace":null},{"id":10629,"version":2,"created":1554931281000,"modified":1554931286000,"deprecated":false,"name":"HLA class I histocompatibility antigen, A-32 alpha chain","accession":"P10314","gene":"HLA-A","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.416669710281058,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4123.756732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.457240582152559,"self":"https://pharos.nih.gov/idg/api/v1/targets(10629)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1408,"href":"https://pharos.nih.gov/idg/api/v1/targets(10629)/properties"},"_links":{"count":946,"href":"https://pharos.nih.gov/idg/api/v1/targets(10629)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10629)/synonyms"},"_publications":{"count":1223,"href":"https://pharos.nih.gov/idg/api/v1/targets(10629)/publications"},"_namespace":null},{"id":10630,"version":3,"created":1554931291000,"modified":1555039514000,"deprecated":false,"name":"Glutathione S-transferase omega-2","accession":"Q9H4Y5","gene":"GSTO2","description":"Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7634272205194474,"antibodyCount":190,"monoclonalCount":40,"pubmedCount":null,"jensenScore":57.560788,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":33.39668433656691,"pubTatorScore":1.7139597895527934,"self":"https://pharos.nih.gov/idg/api/v1/targets(10630)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":406,"href":"https://pharos.nih.gov/idg/api/v1/targets(10630)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(10630)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10630)/synonyms"},"_publications":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10630)/publications"},"_namespace":null},{"id":10631,"version":3,"created":1554931296000,"modified":1555039518000,"deprecated":false,"name":"Basigin","accession":"P35613","gene":"BSG","description":"Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0814192763625434,"antibodyCount":1225,"monoclonalCount":809,"pubmedCount":null,"jensenScore":1335.412677,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":73,"knowledgeAvailability":44.54054467587798,"pubTatorScore":2.8205505635151753,"self":"https://pharos.nih.gov/idg/api/v1/targets(10631)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":878,"href":"https://pharos.nih.gov/idg/api/v1/targets(10631)/properties"},"_links":{"count":1668,"href":"https://pharos.nih.gov/idg/api/v1/targets(10631)/links"},"_synonyms":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(10631)/synonyms"},"_publications":{"count":464,"href":"https://pharos.nih.gov/idg/api/v1/targets(10631)/publications"},"_namespace":null},{"id":10632,"version":2,"created":1554931307000,"modified":1554931310000,"deprecated":false,"name":"SOSS complex subunit B2","accession":"Q96AH0","gene":"NABP1","description":"Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8911656213518142,"antibodyCount":59,"monoclonalCount":13,"pubmedCount":null,"jensenScore":7.835006,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.240346335964944,"pubTatorScore":0.5118833609788743,"self":"https://pharos.nih.gov/idg/api/v1/targets(10632)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(10632)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(10632)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10632)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10632)/publications"},"_namespace":null},{"id":10633,"version":3,"created":1554931311000,"modified":1555039522000,"deprecated":false,"name":"Beta-adducin","accession":"P35612","gene":"ADD2","description":"Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0180414810673954,"antibodyCount":147,"monoclonalCount":2,"pubmedCount":null,"jensenScore":106.54218,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":44.191412119067465,"pubTatorScore":1.5757924446128355,"self":"https://pharos.nih.gov/idg/api/v1/targets(10633)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(10633)/properties"},"_links":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10633)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(10633)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10633)/publications"},"_namespace":null},{"id":10634,"version":2,"created":1554931317000,"modified":1554931322000,"deprecated":false,"name":"Alpha-adducin","accession":"P35611","gene":"ADD1","description":"Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4600110855011454,"antibodyCount":570,"monoclonalCount":71,"pubmedCount":null,"jensenScore":291.865236,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":56.126874020890284,"pubTatorScore":2.3560424978144177,"self":"https://pharos.nih.gov/idg/api/v1/targets(10634)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":608,"href":"https://pharos.nih.gov/idg/api/v1/targets(10634)/properties"},"_links":{"count":1331,"href":"https://pharos.nih.gov/idg/api/v1/targets(10634)/links"},"_synonyms":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(10634)/synonyms"},"_publications":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10634)/publications"},"_namespace":null},{"id":10635,"version":2,"created":1554931325000,"modified":1554931328000,"deprecated":false,"name":"Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4","accession":"Q5VWC8","gene":"HACD4","description":"Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.6355675091039891,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.117757,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.737769256498993,"pubTatorScore":0.26203985791315476,"self":"https://pharos.nih.gov/idg/api/v1/targets(10635)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":234,"href":"https://pharos.nih.gov/idg/api/v1/targets(10635)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(10635)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10635)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10635)/publications"},"_namespace":null},{"id":10636,"version":3,"created":1554931329000,"modified":1555039524000,"deprecated":false,"name":"Transmembrane protein 220","accession":"Q6QAJ8","gene":"TMEM220","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.583333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":19.5143605245608,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10636)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":202,"href":"https://pharos.nih.gov/idg/api/v1/targets(10636)/properties"},"_links":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(10636)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10636)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10636)/publications"},"_namespace":null},{"id":10637,"version":2,"created":1554931332000,"modified":1554931337000,"deprecated":false,"name":"Leucine-rich repeat-containing protein 59","accession":"Q96AG4","gene":"LRRC59","description":"Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5185139442208323,"antibodyCount":77,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.613585,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.357063578630324,"pubTatorScore":1.2639927299212979,"self":"https://pharos.nih.gov/idg/api/v1/targets(10637)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(10637)/properties"},"_links":{"count":1125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10637)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10637)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10637)/publications"},"_namespace":null},{"id":10638,"version":2,"created":1554931338000,"modified":1554931342000,"deprecated":false,"name":"Neurite extension and migration factor","accession":"Q5QGS0","gene":"NEXMIF","description":"Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6962785697002967,"antibodyCount":11,"monoclonalCount":2,"pubmedCount":null,"jensenScore":46.080922,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":1.0586067657164226,"self":"https://pharos.nih.gov/idg/api/v1/targets(10638)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(10638)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(10638)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10638)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10638)/publications"},"_namespace":null},{"id":10639,"version":2,"created":1554931342000,"modified":1554931348000,"deprecated":false,"name":"Claudin-11","accession":"O75508","gene":"CLDN11","description":"Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5661070134638817,"antibodyCount":231,"monoclonalCount":21,"pubmedCount":null,"jensenScore":350.503727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.02518155771546,"pubTatorScore":1.9962578465576581,"self":"https://pharos.nih.gov/idg/api/v1/targets(10639)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(10639)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(10639)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10639)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10639)/publications"},"_namespace":null},{"id":10640,"version":2,"created":1554931349000,"modified":1554931355000,"deprecated":false,"name":"Tumor necrosis factor receptor superfamily member 21","accession":"O75509","gene":"TNFRSF21","description":"Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.23109489343987,"antibodyCount":413,"monoclonalCount":144,"pubmedCount":null,"jensenScore":178.70342,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.94145703855039,"pubTatorScore":1.991891162347092,"self":"https://pharos.nih.gov/idg/api/v1/targets(10640)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(10640)/properties"},"_links":{"count":1025,"href":"https://pharos.nih.gov/idg/api/v1/targets(10640)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10640)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10640)/publications"},"_namespace":null},{"id":10641,"version":3,"created":1554931356000,"modified":1555039525000,"deprecated":false,"name":"Coatomer subunit beta'","accession":"P35606","gene":"COPB2","description":"This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). Interacts with JAGN1.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4073240354346093,"antibodyCount":79,"monoclonalCount":3,"pubmedCount":null,"jensenScore":24.178266,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":39.71116851119883,"pubTatorScore":1.817066682513397,"self":"https://pharos.nih.gov/idg/api/v1/targets(10641)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":416,"href":"https://pharos.nih.gov/idg/api/v1/targets(10641)/properties"},"_links":{"count":1131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10641)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10641)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(10641)/publications"},"_namespace":null},{"id":10642,"version":3,"created":1554931364000,"modified":1555039526000,"deprecated":false,"name":"Alpha-actinin-2","accession":"P35609","gene":"ACTN2","description":"F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8980354896658407,"antibodyCount":245,"monoclonalCount":40,"pubmedCount":null,"jensenScore":72.873988,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.83227717493884,"pubTatorScore":1.3768830267893455,"self":"https://pharos.nih.gov/idg/api/v1/targets(10642)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":401,"href":"https://pharos.nih.gov/idg/api/v1/targets(10642)/properties"},"_links":{"count":1040,"href":"https://pharos.nih.gov/idg/api/v1/targets(10642)/links"},"_synonyms":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(10642)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10642)/publications"},"_namespace":null},{"id":10643,"version":3,"created":1554931370000,"modified":1555039527000,"deprecated":false,"name":"Vesicular inhibitory amino acid transporter","accession":"Q9H598","gene":"SLC32A1","description":"Involved in the uptake of GABA and glycine into the synaptic vesicles.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-2.584939801817533,"antibodyCount":151,"monoclonalCount":8,"pubmedCount":null,"jensenScore":352.566142,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.924142961785975,"pubTatorScore":1.6625411307685105,"self":"https://pharos.nih.gov/idg/api/v1/targets(10643)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":243,"href":"https://pharos.nih.gov/idg/api/v1/targets(10643)/properties"},"_links":{"count":659,"href":"https://pharos.nih.gov/idg/api/v1/targets(10643)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10643)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10643)/publications"},"_namespace":null},{"id":10644,"version":2,"created":1554931374000,"modified":1554931386000,"deprecated":false,"name":"Acrosin","accession":"P10323","gene":"ACR","description":"Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.0240400062957504,"antibodyCount":127,"monoclonalCount":20,"pubmedCount":null,"jensenScore":1039.521629,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.04288288693788,"pubTatorScore":3.0439322358785827,"self":"https://pharos.nih.gov/idg/api/v1/targets(10644)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10644)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(10644)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10644)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10644)/publications"},"_namespace":null},{"id":10645,"version":2,"created":1554931387000,"modified":1554931390000,"deprecated":false,"name":"Solute carrier family 25 member 46","accession":"Q96AG3","gene":"SLC25A46","description":"May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.4785232463599507,"antibodyCount":74,"monoclonalCount":1,"pubmedCount":null,"jensenScore":288.755134,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.46189687564996,"pubTatorScore":0.4555002261337457,"self":"https://pharos.nih.gov/idg/api/v1/targets(10645)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(10645)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(10645)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10645)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10645)/publications"},"_namespace":null},{"id":10646,"version":2,"created":1554931391000,"modified":1554931394000,"deprecated":false,"name":"Protein lyl-1","accession":"P12980","gene":"LYL1","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.5205247459853608,"antibodyCount":126,"monoclonalCount":13,"pubmedCount":null,"jensenScore":35.27029,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.34416561587525,"pubTatorScore":1.4447706948611618,"self":"https://pharos.nih.gov/idg/api/v1/targets(10646)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10646)/properties"},"_links":{"count":806,"href":"https://pharos.nih.gov/idg/api/v1/targets(10646)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10646)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10646)/publications"},"_namespace":null},{"id":10647,"version":3,"created":1554931395000,"modified":1555039528000,"deprecated":false,"name":"Zinc finger protein 800","accession":"Q2TB10","gene":"ZNF800","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":47,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.186437767530048,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10647)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":329,"href":"https://pharos.nih.gov/idg/api/v1/targets(10647)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(10647)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10647)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10647)/publications"},"_namespace":null},{"id":10648,"version":3,"created":1554931398000,"modified":1555039530000,"deprecated":false,"name":"Golgin subfamily A member 7B","accession":"Q2TAP0","gene":"GOLGA7B","description":"May be involved in protein transport from Golgi to cell surface.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":20.006856056438675,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10648)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(10648)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(10648)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10648)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10648)/publications"},"_namespace":null},{"id":10649,"version":3,"created":1554931404000,"modified":1555039531000,"deprecated":false,"name":"Dual specificity protein phosphatase 21","accession":"Q9H596","gene":"DUSP21","description":"Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.02348109633207232,"antibodyCount":30,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.055556,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":16.632801045462756,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10649)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10649)/properties"},"_links":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10649)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10649)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10649)/publications"},"_namespace":null},{"id":10650,"version":3,"created":1554931405000,"modified":1555039532000,"deprecated":false,"name":"HLA class I histocompatibility antigen, Cw-7 alpha chain","accession":"P10321","gene":"HLA-C","description":"Involved in the presentation of foreign antigens to the immune system.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9066077357830662,"antibodyCount":138,"monoclonalCount":24,"pubmedCount":null,"jensenScore":830.506278,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":0.0,"pubTatorScore":2.16651468793666,"self":"https://pharos.nih.gov/idg/api/v1/targets(10650)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1093,"href":"https://pharos.nih.gov/idg/api/v1/targets(10650)/properties"},"_links":{"count":1245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10650)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10650)/synonyms"},"_publications":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(10650)/publications"},"_namespace":null},{"id":10651,"version":3,"created":1554931413000,"modified":1555039536000,"deprecated":false,"name":"Regulator of cell cycle RGCC","accession":"Q9H4X1","gene":"RGCC","description":"Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.323820533536321,"antibodyCount":54,"monoclonalCount":9,"pubmedCount":null,"jensenScore":150.770421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.861552255858705,"pubTatorScore":1.4267306629073337,"self":"https://pharos.nih.gov/idg/api/v1/targets(10651)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":408,"href":"https://pharos.nih.gov/idg/api/v1/targets(10651)/properties"},"_links":{"count":1081,"href":"https://pharos.nih.gov/idg/api/v1/targets(10651)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10651)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10651)/publications"},"_namespace":null},{"id":10652,"version":3,"created":1554931419000,"modified":1555039537000,"deprecated":false,"name":"Non-specific lipid-transfer protein","accession":"P22307","gene":"SCP2","description":"Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.663282167799071,"antibodyCount":314,"monoclonalCount":32,"pubmedCount":null,"jensenScore":485.388753,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":46.29393192306605,"pubTatorScore":2.238157742626385,"self":"https://pharos.nih.gov/idg/api/v1/targets(10652)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(10652)/properties"},"_links":{"count":1368,"href":"https://pharos.nih.gov/idg/api/v1/targets(10652)/links"},"_synonyms":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(10652)/synonyms"},"_publications":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10652)/publications"},"_namespace":null},{"id":10653,"version":3,"created":1554931428000,"modified":1555039539000,"deprecated":false,"name":"Receptor-transporting protein 2","accession":"Q5QGT7","gene":"RTP2","description":"Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9311187105921871,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.804581,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":12.209510408203124,"pubTatorScore":0.5272001620624317,"self":"https://pharos.nih.gov/idg/api/v1/targets(10653)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10653)/properties"},"_links":{"count":217,"href":"https://pharos.nih.gov/idg/api/v1/targets(10653)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10653)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10653)/publications"},"_namespace":null},{"id":10654,"version":3,"created":1554931428000,"modified":1555039540000,"deprecated":false,"name":"Growth-regulated alpha protein","accession":"P09341","gene":"CXCL1","description":"Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.1422997154098353,"antibodyCount":517,"monoclonalCount":152,"pubmedCount":null,"jensenScore":1286.066319,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":35.20534811603678,"pubTatorScore":2.623208307609723,"self":"https://pharos.nih.gov/idg/api/v1/targets(10654)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(10654)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(10654)/links"},"_synonyms":{"count":111,"href":"https://pharos.nih.gov/idg/api/v1/targets(10654)/synonyms"},"_publications":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(10654)/publications"},"_namespace":null},{"id":10655,"version":3,"created":1554931436000,"modified":1555039541000,"deprecated":false,"name":"Protein asteroid homolog 1","accession":"Q2TB18","gene":"ASTE1","description":"Possible role in EGF receptor signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6910393748098194,"antibodyCount":106,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.042193,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":28.456231519947398,"pubTatorScore":0.2844307338445195,"self":"https://pharos.nih.gov/idg/api/v1/targets(10655)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(10655)/properties"},"_links":{"count":856,"href":"https://pharos.nih.gov/idg/api/v1/targets(10655)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10655)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10655)/publications"},"_namespace":null},{"id":10656,"version":2,"created":1554931441000,"modified":1554931450000,"deprecated":false,"name":"UDP-glucuronosyltransferase 1-1","accession":"P22309","gene":"UGT1A1","description":"UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.95436412892178,"antibodyCount":146,"monoclonalCount":6,"pubmedCount":null,"jensenScore":932.54042,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.01779655584181,"pubTatorScore":3.1198463994021033,"self":"https://pharos.nih.gov/idg/api/v1/targets(10656)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(10656)/properties"},"_links":{"count":816,"href":"https://pharos.nih.gov/idg/api/v1/targets(10656)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10656)/synonyms"},"_publications":{"count":617,"href":"https://pharos.nih.gov/idg/api/v1/targets(10656)/publications"},"_namespace":null},{"id":10657,"version":2,"created":1554931452000,"modified":1554931453000,"deprecated":false,"name":"Testis-specific basic protein Y 2","accession":"O14599","gene":"BPY2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9086697071282549,"antibodyCount":24,"monoclonalCount":0,"pubmedCount":null,"jensenScore":7.553461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.3849682029700965,"pubTatorScore":0.5228787018508873,"self":"https://pharos.nih.gov/idg/api/v1/targets(10657)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10657)/properties"},"_links":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10657)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10657)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10657)/publications"},"_namespace":null},{"id":10658,"version":3,"created":1554931453000,"modified":1555039542000,"deprecated":false,"name":"Plasma membrane calcium-transporting ATPase 4","accession":"P23634","gene":"ATP2B4","description":"Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.0588942307908566,"antibodyCount":121,"monoclonalCount":37,"pubmedCount":null,"jensenScore":122.844555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":49.4319401084971,"pubTatorScore":2.0116207714787597,"self":"https://pharos.nih.gov/idg/api/v1/targets(10658)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":562,"href":"https://pharos.nih.gov/idg/api/v1/targets(10658)/properties"},"_links":{"count":1264,"href":"https://pharos.nih.gov/idg/api/v1/targets(10658)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10658)/synonyms"},"_publications":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10658)/publications"},"_namespace":null},{"id":10659,"version":3,"created":1554931460000,"modified":1555039544000,"deprecated":false,"name":"Testis-specific basic protein Y 1","accession":"O14598","gene":"VCY","description":"May mediate a process in spermatogenesis or may play a role in sex ratio distortion.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7472665256376252,"antibodyCount":23,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.017147,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":4.888428940126569,"pubTatorScore":0.7852451037238457,"self":"https://pharos.nih.gov/idg/api/v1/targets(10659)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10659)/properties"},"_links":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10659)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10659)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10659)/publications"},"_namespace":null},{"id":10660,"version":2,"created":1554931460000,"modified":1554931466000,"deprecated":false,"name":"2'-5'-oligoadenylate synthase 1","accession":"P00973","gene":"OAS1","description":"Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.0131754372471087,"antibodyCount":238,"monoclonalCount":19,"pubmedCount":null,"jensenScore":92.302324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.54284576978173,"pubTatorScore":1.9508551112265584,"self":"https://pharos.nih.gov/idg/api/v1/targets(10660)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(10660)/properties"},"_links":{"count":1006,"href":"https://pharos.nih.gov/idg/api/v1/targets(10660)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(10660)/synonyms"},"_publications":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10660)/publications"},"_namespace":null},{"id":10661,"version":3,"created":1554931467000,"modified":1555039545000,"deprecated":false,"name":"Iduronate 2-sulfatase","accession":"P22304","gene":"IDS","description":"Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8500444435224968,"antibodyCount":138,"monoclonalCount":21,"pubmedCount":null,"jensenScore":64.147004,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":25,"knowledgeAvailability":45.187659219416915,"pubTatorScore":3.04478117669098,"self":"https://pharos.nih.gov/idg/api/v1/targets(10661)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(10661)/properties"},"_links":{"count":1003,"href":"https://pharos.nih.gov/idg/api/v1/targets(10661)/links"},"_synonyms":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10661)/synonyms"},"_publications":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10661)/publications"},"_namespace":null},{"id":10662,"version":3,"created":1554931474000,"modified":1554932232000,"deprecated":false,"name":"Acetylcholinesterase","accession":"P22303","gene":"ACHE","description":"Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-3.49768215023426,"antibodyCount":505,"monoclonalCount":152,"pubmedCount":null,"jensenScore":2470.471883,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.04280414757611,"pubTatorScore":3.668763049488256,"self":"https://pharos.nih.gov/idg/api/v1/targets(10662)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":528,"href":"https://pharos.nih.gov/idg/api/v1/targets(10662)/properties"},"_links":{"count":3029,"href":"https://pharos.nih.gov/idg/api/v1/targets(10662)/links"},"_synonyms":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(10662)/synonyms"},"_publications":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(10662)/publications"},"_namespace":null},{"id":10663,"version":3,"created":1554932238000,"modified":1555039547000,"deprecated":false,"name":"DNA repair protein RAD51 homolog 1","accession":"Q06609","gene":"RAD51","description":"Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.8264932297918954,"antibodyCount":594,"monoclonalCount":185,"pubmedCount":null,"jensenScore":6589.978188,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":53.27665714618279,"pubTatorScore":3.295560534039967,"self":"https://pharos.nih.gov/idg/api/v1/targets(10663)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":929,"href":"https://pharos.nih.gov/idg/api/v1/targets(10663)/properties"},"_links":{"count":1571,"href":"https://pharos.nih.gov/idg/api/v1/targets(10663)/links"},"_synonyms":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(10663)/synonyms"},"_publications":{"count":517,"href":"https://pharos.nih.gov/idg/api/v1/targets(10663)/publications"},"_namespace":null},{"id":10664,"version":3,"created":1554932250000,"modified":1555039550000,"deprecated":false,"name":"Interleukin-10","accession":"P22301","gene":"IL10","description":"Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-4.105241005628108,"antibodyCount":1157,"monoclonalCount":627,"pubmedCount":null,"jensenScore":12406.781471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":41.7291366436566,"pubTatorScore":3.9428603385097025,"self":"https://pharos.nih.gov/idg/api/v1/targets(10664)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":3117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10664)/properties"},"_links":{"count":3064,"href":"https://pharos.nih.gov/idg/api/v1/targets(10664)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10664)/synonyms"},"_publications":{"count":2700,"href":"https://pharos.nih.gov/idg/api/v1/targets(10664)/publications"},"_namespace":null},{"id":10665,"version":3,"created":1554932279000,"modified":1555039561000,"deprecated":false,"name":"X-ray repair cross-complementing protein 6","accession":"P12956","gene":"XRCC6","description":"Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8642378394579118,"antibodyCount":865,"monoclonalCount":248,"pubmedCount":null,"jensenScore":688.297551,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":53.56037849389104,"pubTatorScore":2.480685743680845,"self":"https://pharos.nih.gov/idg/api/v1/targets(10665)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(10665)/properties"},"_links":{"count":1409,"href":"https://pharos.nih.gov/idg/api/v1/targets(10665)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(10665)/synonyms"},"_publications":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(10665)/publications"},"_namespace":null},{"id":10666,"version":2,"created":1554932288000,"modified":1554932290000,"deprecated":false,"name":"POTE ankyrin domain family member F","accession":"A5A3E0","gene":"POTEF","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.019146153562354,"antibodyCount":131,"monoclonalCount":24,"pubmedCount":null,"jensenScore":92.711268,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.883561685955154,"pubTatorScore":2.9970572790403853,"self":"https://pharos.nih.gov/idg/api/v1/targets(10666)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(10666)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(10666)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10666)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10666)/publications"},"_namespace":null},{"id":10667,"version":2,"created":1554932291000,"modified":1554932300000,"deprecated":false,"name":"Xaa-Pro dipeptidase","accession":"P12955","gene":"PEPD","description":"Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.975378892950458,"antibodyCount":157,"monoclonalCount":44,"pubmedCount":null,"jensenScore":963.827694,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":48.05132369178615,"pubTatorScore":2.647949438938202,"self":"https://pharos.nih.gov/idg/api/v1/targets(10667)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":487,"href":"https://pharos.nih.gov/idg/api/v1/targets(10667)/properties"},"_links":{"count":1287,"href":"https://pharos.nih.gov/idg/api/v1/targets(10667)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10667)/synonyms"},"_publications":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10667)/publications"},"_namespace":null},{"id":10668,"version":3,"created":1554932301000,"modified":1555039564000,"deprecated":false,"name":"HEAT repeat-containing protein 1","accession":"Q9H583","gene":"HEATR1","description":"Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7621782315007067,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.777849,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":41.920200048177236,"pubTatorScore":0.25123244612501977,"self":"https://pharos.nih.gov/idg/api/v1/targets(10668)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10668)/properties"},"_links":{"count":1017,"href":"https://pharos.nih.gov/idg/api/v1/targets(10668)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10668)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10668)/publications"},"_namespace":null},{"id":10669,"version":2,"created":1554932306000,"modified":1554932309000,"deprecated":false,"name":"Transcription factor COE3","accession":"Q9H4W6","gene":"EBF3","description":"Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.129260260946389,"antibodyCount":131,"monoclonalCount":67,"pubmedCount":null,"jensenScore":135.147862,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.636781157331065,"pubTatorScore":1.577824906902093,"self":"https://pharos.nih.gov/idg/api/v1/targets(10669)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":229,"href":"https://pharos.nih.gov/idg/api/v1/targets(10669)/properties"},"_links":{"count":772,"href":"https://pharos.nih.gov/idg/api/v1/targets(10669)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10669)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10669)/publications"},"_namespace":null},{"id":10670,"version":2,"created":1554932310000,"modified":1554932312000,"deprecated":false,"name":"Phospholipid phosphatase-related protein type 5","accession":"Q32ZL2","gene":"PLPPR5","description":"Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.07918124778480276,"antibodyCount":87,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.142857,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.6483600109809317,"self":"https://pharos.nih.gov/idg/api/v1/targets(10670)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":154,"href":"https://pharos.nih.gov/idg/api/v1/targets(10670)/properties"},"_links":{"count":555,"href":"https://pharos.nih.gov/idg/api/v1/targets(10670)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10670)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10670)/publications"},"_namespace":null},{"id":10671,"version":2,"created":1554932313000,"modified":1554932318000,"deprecated":false,"name":"Tetratricopeptide repeat protein 17","accession":"Q96AE7","gene":"TTC17","description":"Plays a role in primary ciliogenesis by modulating actin polymerization.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":31,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.916667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.41887625848159,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10671)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(10671)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(10671)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10671)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10671)/publications"},"_namespace":null},{"id":10672,"version":2,"created":1554932318000,"modified":1554932322000,"deprecated":false,"name":"Zinc finger protein 644","accession":"Q9H582","gene":"ZNF644","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.3322375474814856,"antibodyCount":26,"monoclonalCount":2,"pubmedCount":null,"jensenScore":20.426333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.76247587295799,"pubTatorScore":1.2557900686239236,"self":"https://pharos.nih.gov/idg/api/v1/targets(10672)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(10672)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(10672)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10672)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10672)/publications"},"_namespace":null},{"id":10673,"version":2,"created":1554932323000,"modified":1554932327000,"deprecated":false,"name":"Far upstream element-binding protein 1","accession":"Q96AE4","gene":"FUBP1","description":"Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5852231312019447,"antibodyCount":209,"monoclonalCount":52,"pubmedCount":null,"jensenScore":39.73707,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.47729449746023,"pubTatorScore":1.6508155253338332,"self":"https://pharos.nih.gov/idg/api/v1/targets(10673)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":450,"href":"https://pharos.nih.gov/idg/api/v1/targets(10673)/properties"},"_links":{"count":1119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10673)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10673)/synonyms"},"_publications":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10673)/publications"},"_namespace":null},{"id":10674,"version":2,"created":1554932328000,"modified":1554932333000,"deprecated":false,"name":"Septin-8","accession":"Q92599","gene":"SEPT8","description":"Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7247031605826386,"antibodyCount":171,"monoclonalCount":12,"pubmedCount":null,"jensenScore":51.032686,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.5688292705015,"pubTatorScore":1.210566903760426,"self":"https://pharos.nih.gov/idg/api/v1/targets(10674)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":353,"href":"https://pharos.nih.gov/idg/api/v1/targets(10674)/properties"},"_links":{"count":1086,"href":"https://pharos.nih.gov/idg/api/v1/targets(10674)/links"},"_synonyms":{"count":110,"href":"https://pharos.nih.gov/idg/api/v1/targets(10674)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10674)/publications"},"_namespace":null},{"id":10675,"version":2,"created":1554932334000,"modified":1554932340000,"deprecated":false,"name":"Heat shock protein 105 kDa","accession":"Q92598","gene":"HSPH1","description":"Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6937133253194347,"antibodyCount":316,"monoclonalCount":62,"pubmedCount":null,"jensenScore":52.417021,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.28397068212881,"pubTatorScore":1.5880095380119608,"self":"https://pharos.nih.gov/idg/api/v1/targets(10675)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(10675)/properties"},"_links":{"count":1138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10675)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10675)/synonyms"},"_publications":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10675)/publications"},"_namespace":null},{"id":10676,"version":2,"created":1554932341000,"modified":1554932348000,"deprecated":false,"name":"Protein NDRG1","accession":"Q92597","gene":"NDRG1","description":"Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.312247260893694,"antibodyCount":402,"monoclonalCount":76,"pubmedCount":null,"jensenScore":245.753429,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":54.62482087995518,"pubTatorScore":2.431612656158976,"self":"https://pharos.nih.gov/idg/api/v1/targets(10676)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":620,"href":"https://pharos.nih.gov/idg/api/v1/targets(10676)/properties"},"_links":{"count":1407,"href":"https://pharos.nih.gov/idg/api/v1/targets(10676)/links"},"_synonyms":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10676)/synonyms"},"_publications":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(10676)/publications"},"_namespace":null},{"id":10677,"version":3,"created":1554932350000,"modified":1555039566000,"deprecated":false,"name":"Guanine nucleotide-binding protein-like 1","accession":"P36915","gene":"GNL1","description":"Possible regulatory or functional link with the histocompatibility cluster.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2935672049153686,"antibodyCount":185,"monoclonalCount":3,"pubmedCount":null,"jensenScore":19.218468,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":37.16885516926868,"pubTatorScore":1.0980665440064554,"self":"https://pharos.nih.gov/idg/api/v1/targets(10677)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(10677)/properties"},"_links":{"count":935,"href":"https://pharos.nih.gov/idg/api/v1/targets(10677)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10677)/synonyms"},"_publications":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10677)/publications"},"_namespace":null},{"id":10678,"version":3,"created":1554932355000,"modified":1555039567000,"deprecated":false,"name":"Centromere protein W","accession":"Q5EE01","gene":"CENPW","description":"Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1203882648412218,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.112059,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":24.410267651863666,"pubTatorScore":1.1240786882327676,"self":"https://pharos.nih.gov/idg/api/v1/targets(10678)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(10678)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(10678)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10678)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10678)/publications"},"_namespace":null},{"id":10679,"version":2,"created":1554932359000,"modified":1554932363000,"deprecated":false,"name":"Ras-related protein R-Ras","accession":"P10301","gene":"RRAS","description":"Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.158701234889558,"antibodyCount":150,"monoclonalCount":40,"pubmedCount":null,"jensenScore":149.819863,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.32935039344658,"pubTatorScore":1.5330001506799602,"self":"https://pharos.nih.gov/idg/api/v1/targets(10679)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(10679)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(10679)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10679)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10679)/publications"},"_namespace":null},{"id":10680,"version":2,"created":1554932364000,"modified":1554932367000,"deprecated":false,"name":"Protein MROH8","accession":"Q9H579","gene":"MROH8","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6989700043360189,"antibodyCount":64,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.090909,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.410971591540235,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(10680)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(10680)/properties"},"_links":{"count":760,"href":"https://pharos.nih.gov/idg/api/v1/targets(10680)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10680)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10680)/publications"},"_namespace":null},{"id":10681,"version":3,"created":1554932367000,"modified":1555039568000,"deprecated":false,"name":"Patatin-like phospholipase domain-containing protein 2","accession":"Q96AD5","gene":"PNPLA2","description":"Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.6828458762009726,"antibodyCount":398,"monoclonalCount":80,"pubmedCount":null,"jensenScore":486.416989,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":40.924342604640636,"pubTatorScore":2.744877823276021,"self":"https://pharos.nih.gov/idg/api/v1/targets(10681)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":392,"href":"https://pharos.nih.gov/idg/api/v1/targets(10681)/properties"},"_links":{"count":1020,"href":"https://pharos.nih.gov/idg/api/v1/targets(10681)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10681)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10681)/publications"},"_namespace":null},{"id":10682,"version":3,"created":1554932374000,"modified":1555039570000,"deprecated":false,"name":"Activated CDC42 kinase 1","accession":"Q07912","gene":"TNK2","description":"Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.9037885465962479,"antibodyCount":591,"monoclonalCount":21,"pubmedCount":null,"jensenScore":93.358533,"patentCount":12981,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":49.33006899898745,"pubTatorScore":1.9869614973997498,"self":"https://pharos.nih.gov/idg/api/v1/targets(10682)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":476,"href":"https://pharos.nih.gov/idg/api/v1/targets(10682)/properties"},"_links":{"count":1176,"href":"https://pharos.nih.gov/idg/api/v1/targets(10682)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(10682)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10682)/publications"},"_namespace":null},{"id":10683,"version":3,"created":1554932405000,"modified":1555039572000,"deprecated":false,"name":"C-C motif chemokine 17","accession":"Q92583","gene":"CCL17","description":"Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6572734193929812,"antibodyCount":344,"monoclonalCount":80,"pubmedCount":null,"jensenScore":488.964247,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":26.128342374960134,"pubTatorScore":2.437028795210972,"self":"https://pharos.nih.gov/idg/api/v1/targets(10683)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(10683)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(10683)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10683)/synonyms"},"_publications":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10683)/publications"},"_namespace":null},{"id":10684,"version":2,"created":1554932408000,"modified":1554932410000,"deprecated":false,"name":"ATP synthase subunit g 2, mitochondrial","accession":"Q7Z4Y8","gene":"ATP5MGL","description":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10684)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/properties"},"_links":{"count":565,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/links"},"_synonyms":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10684)/publications"},"_namespace":null},{"id":10685,"version":3,"created":1554932410000,"modified":1555039574000,"deprecated":false,"name":"Sodium/hydrogen exchanger 6","accession":"Q92581","gene":"SLC9A6","description":"Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.8914691394041852,"antibodyCount":96,"monoclonalCount":7,"pubmedCount":null,"jensenScore":78.023884,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":21,"knowledgeAvailability":39.289905934562725,"pubTatorScore":1.8208497758168436,"self":"https://pharos.nih.gov/idg/api/v1/targets(10685)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":413,"href":"https://pharos.nih.gov/idg/api/v1/targets(10685)/properties"},"_links":{"count":1198,"href":"https://pharos.nih.gov/idg/api/v1/targets(10685)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10685)/synonyms"},"_publications":{"count":36,"href":"https://pharos.nih.gov/idg/api/v1/targets(10685)/publications"},"_namespace":null},{"id":10686,"version":2,"created":1554932417000,"modified":1554932418000,"deprecated":false,"name":"Factor VIII intron 22 protein","accession":"P23610","gene":"F8A1","description":"Not known. Possible housekeeping role.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4762068555415746,"antibodyCount":49,"monoclonalCount":2,"pubmedCount":null,"jensenScore":17.163212,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.413526806110518,"pubTatorScore":1.3690947763063042,"self":"https://pharos.nih.gov/idg/api/v1/targets(10686)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":201,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/properties"},"_links":{"count":535,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10686)/publications"},"_namespace":null},{"id":10687,"version":4,"created":1554932419000,"modified":1555039578000,"deprecated":false,"name":"Cyclin-dependent kinase 2","accession":"P24941","gene":"CDK2","description":"Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-3.4426612552140847,"antibodyCount":1114,"monoclonalCount":310,"pubmedCount":null,"jensenScore":2522.81647,"patentCount":142021,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":66.10358282077244,"pubTatorScore":3.1994737051848943,"self":"https://pharos.nih.gov/idg/api/v1/targets(10687)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1049,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/properties"},"_links":{"count":1880,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/links"},"_synonyms":{"count":1404,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/synonyms"},"_publications":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(10687)/publications"},"_namespace":null},{"id":10688,"version":3,"created":1554932550000,"modified":1555039583000,"deprecated":false,"name":"Mastermind-like protein 1","accession":"Q92585","gene":"MAML1","description":"Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6596239101251231,"antibodyCount":189,"monoclonalCount":16,"pubmedCount":null,"jensenScore":41.274076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":40.190771922888864,"pubTatorScore":1.5454175814880102,"self":"https://pharos.nih.gov/idg/api/v1/targets(10688)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/properties"},"_links":{"count":1010,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10688)/publications"},"_namespace":null},{"id":10689,"version":3,"created":1554932554000,"modified":1555039584000,"deprecated":false,"name":"Serine protease inhibitor Kazal-type 1","accession":"P00995","gene":"SPINK1","description":"In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.8540674408241307,"antibodyCount":190,"monoclonalCount":46,"pubmedCount":null,"jensenScore":743.990046,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":31.837224221663654,"pubTatorScore":3.0974491598603118,"self":"https://pharos.nih.gov/idg/api/v1/targets(10689)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/synonyms"},"_publications":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(10689)/publications"},"_namespace":null},{"id":10690,"version":3,"created":1554932559000,"modified":1555039586000,"deprecated":false,"name":"CD48 antigen","accession":"P09326","gene":"CD48","description":"Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5770688987513197,"antibodyCount":679,"monoclonalCount":455,"pubmedCount":null,"jensenScore":369.226204,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":33.44564341186365,"pubTatorScore":2.18179230102412,"self":"https://pharos.nih.gov/idg/api/v1/targets(10690)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10690)/publications"},"_namespace":null},{"id":10691,"version":2,"created":1554932564000,"modified":1554932568000,"deprecated":false,"name":"Villin-1","accession":"P09327","gene":"VIL1","description":"Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2013728305666236,"antibodyCount":349,"monoclonalCount":188,"pubmedCount":null,"jensenScore":162.538054,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.510772497548277,"pubTatorScore":1.9239589740213998,"self":"https://pharos.nih.gov/idg/api/v1/targets(10691)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/properties"},"_links":{"count":855,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10691)/publications"},"_namespace":null},{"id":10692,"version":2,"created":1554932569000,"modified":1554932573000,"deprecated":false,"name":"BolA-like protein 2","accession":"Q9H3K6","gene":"BOLA2B","description":"Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3969738343799864,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.487281,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.62404083932053,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10692)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/properties"},"_links":{"count":1751,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10692)/publications"},"_namespace":null},{"id":10693,"version":3,"created":1554932574000,"modified":1554932606000,"deprecated":false,"name":"Disintegrin and metalloproteinase domain-containing protein 10","accession":"O14672","gene":"ADAM10","description":"Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.6465184732969074,"antibodyCount":384,"monoclonalCount":123,"pubmedCount":null,"jensenScore":422.39721,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":53.28484256263841,"pubTatorScore":2.5218180030042308,"self":"https://pharos.nih.gov/idg/api/v1/targets(10693)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":737,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/properties"},"_links":{"count":1552,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/synonyms"},"_publications":{"count":281,"href":"https://pharos.nih.gov/idg/api/v1/targets(10693)/publications"},"_namespace":null},{"id":10694,"version":3,"created":1554932608000,"modified":1555039588000,"deprecated":false,"name":"Growth hormone-inducible transmembrane protein","accession":"Q9H3K2","gene":"GHITM","description":"Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8220723783580162,"antibodyCount":166,"monoclonalCount":2,"pubmedCount":null,"jensenScore":66.536151,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":33.586785827158195,"pubTatorScore":1.3561017659995327,"self":"https://pharos.nih.gov/idg/api/v1/targets(10694)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/properties"},"_links":{"count":1058,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10694)/publications"},"_namespace":null},{"id":10695,"version":3,"created":1554932613000,"modified":1555039589000,"deprecated":false,"name":"ADP-ribosylation factor-like protein 13B","accession":"Q3SXY8","gene":"ARL13B","description":"Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5120468493328956,"antibodyCount":74,"monoclonalCount":8,"pubmedCount":null,"jensenScore":32.927493,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":32.04389531379206,"pubTatorScore":1.2550251522241294,"self":"https://pharos.nih.gov/idg/api/v1/targets(10695)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/properties"},"_links":{"count":968,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/synonyms"},"_publications":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10695)/publications"},"_namespace":null},{"id":10696,"version":2,"created":1554932617000,"modified":1554932622000,"deprecated":false,"name":"Dyslexia-associated protein KIAA0319","accession":"Q5VV43","gene":"KIAA0319","description":"Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6533214267722187,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":48.226046,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.61977136193259,"pubTatorScore":1.7868387831894277,"self":"https://pharos.nih.gov/idg/api/v1/targets(10696)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/properties"},"_links":{"count":959,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/synonyms"},"_publications":{"count":51,"href":"https://pharos.nih.gov/idg/api/v1/targets(10696)/publications"},"_namespace":null},{"id":10697,"version":3,"created":1554932623000,"modified":1555039590000,"deprecated":false,"name":"Threonylcarbamoyladenosine tRNA methylthiotransferase","accession":"Q5VV42","gene":"CDKAL1","description":"Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8202704487347459,"antibodyCount":160,"monoclonalCount":6,"pubmedCount":null,"jensenScore":71.26196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":40.73915089840046,"pubTatorScore":1.9387441643972352,"self":"https://pharos.nih.gov/idg/api/v1/targets(10697)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":473,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/links"},"_synonyms":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/synonyms"},"_publications":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(10697)/publications"},"_namespace":null},{"id":10698,"version":3,"created":1554932628000,"modified":1555039592000,"deprecated":false,"name":"Rho guanine nucleotide exchange factor 16","accession":"Q5VV41","gene":"ARHGEF16","description":"Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.373880429436489,"antibodyCount":97,"monoclonalCount":5,"pubmedCount":null,"jensenScore":232.283138,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":30.993553676309624,"pubTatorScore":0.7190165581133353,"self":"https://pharos.nih.gov/idg/api/v1/targets(10698)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10698)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(10698)/links"},"_synonyms":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10698)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10698)/publications"},"_namespace":null},{"id":10699,"version":2,"created":1554932632000,"modified":1554932634000,"deprecated":false,"name":"Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3","accession":"Q3SXY7","gene":"LRIT3","description":"Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519). Could be a regulator of the FGFRs (PubMed:22673519).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.436881713858682,"antibodyCount":64,"monoclonalCount":21,"pubmedCount":null,"jensenScore":4.174458,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.146936220044594,"pubTatorScore":0.44083401816263645,"self":"https://pharos.nih.gov/idg/api/v1/targets(10699)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(10699)/properties"},"_links":{"count":793,"href":"https://pharos.nih.gov/idg/api/v1/targets(10699)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10699)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10699)/publications"},"_namespace":null},{"id":10700,"version":3,"created":1554932635000,"modified":1555039593000,"deprecated":false,"name":"Syntaxin-16","accession":"O14662","gene":"STX16","description":"SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.421494078156852,"antibodyCount":116,"monoclonalCount":9,"pubmedCount":null,"jensenScore":22.388201,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":42.797406675399344,"pubTatorScore":1.6376989009992489,"self":"https://pharos.nih.gov/idg/api/v1/targets(10700)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(10700)/properties"},"_links":{"count":1146,"href":"https://pharos.nih.gov/idg/api/v1/targets(10700)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10700)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10700)/publications"},"_namespace":null},{"id":10701,"version":2,"created":1554932641000,"modified":1554932643000,"deprecated":false,"name":"Transmembrane gamma-carboxyglutamic acid protein 2","accession":"O14669","gene":"PRRG2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5642714347815074,"antibodyCount":48,"monoclonalCount":12,"pubmedCount":null,"jensenScore":3.225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.46507275733734,"pubTatorScore":0.6827466224278846,"self":"https://pharos.nih.gov/idg/api/v1/targets(10701)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":276,"href":"https://pharos.nih.gov/idg/api/v1/targets(10701)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(10701)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10701)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10701)/publications"},"_namespace":null},{"id":10702,"version":2,"created":1554932644000,"modified":1554932647000,"deprecated":false,"name":"Transmembrane gamma-carboxyglutamic acid protein 1","accession":"O14668","gene":"PRRG1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0032450684934235,"antibodyCount":96,"monoclonalCount":8,"pubmedCount":null,"jensenScore":9.206227,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.823153018149284,"pubTatorScore":0.48575775809497396,"self":"https://pharos.nih.gov/idg/api/v1/targets(10702)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":223,"href":"https://pharos.nih.gov/idg/api/v1/targets(10702)/properties"},"_links":{"count":812,"href":"https://pharos.nih.gov/idg/api/v1/targets(10702)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10702)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10702)/publications"},"_namespace":null},{"id":10703,"version":3,"created":1554932647000,"modified":1555039595000,"deprecated":false,"name":"Probable peptide chain release factor C12orf65, mitochondrial","accession":"Q9H3J6","gene":"C12orf65","description":"May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion. May help rescuing stalled mitoribosomes during translation (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9478490924340524,"antibodyCount":32,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.34008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":0.0,"pubTatorScore":1.1022205540680148,"self":"https://pharos.nih.gov/idg/api/v1/targets(10703)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(10703)/properties"},"_links":{"count":914,"href":"https://pharos.nih.gov/idg/api/v1/targets(10703)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10703)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10703)/publications"},"_namespace":null},{"id":10704,"version":2,"created":1554932652000,"modified":1554932656000,"deprecated":false,"name":"Etoposide-induced protein 2.4 homolog","accession":"O14681","gene":"EI24","description":"Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3193622176663986,"antibodyCount":128,"monoclonalCount":3,"pubmedCount":null,"jensenScore":23.379848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.933914920038816,"pubTatorScore":1.0823206779452403,"self":"https://pharos.nih.gov/idg/api/v1/targets(10704)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":382,"href":"https://pharos.nih.gov/idg/api/v1/targets(10704)/properties"},"_links":{"count":1066,"href":"https://pharos.nih.gov/idg/api/v1/targets(10704)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10704)/synonyms"},"_publications":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10704)/publications"},"_namespace":null},{"id":10705,"version":2,"created":1554932656000,"modified":1554932658000,"deprecated":false,"name":"Importin subunit alpha-8","accession":"A9QM74","gene":"KPNA7","description":"Functions in nuclear protein import.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7994226080276194,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.251112,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.145932907329058,"pubTatorScore":0.7247308210045759,"self":"https://pharos.nih.gov/idg/api/v1/targets(10705)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(10705)/properties"},"_links":{"count":486,"href":"https://pharos.nih.gov/idg/api/v1/targets(10705)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10705)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10705)/publications"},"_namespace":null},{"id":10706,"version":2,"created":1554932659000,"modified":1554932661000,"deprecated":false,"name":"Tumor protein p53-inducible protein 11","accession":"O14683","gene":"TP53I11","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.19339314119196738,"antibodyCount":118,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.452561,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.89387632647108,"pubTatorScore":0.9462643576144698,"self":"https://pharos.nih.gov/idg/api/v1/targets(10706)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(10706)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(10706)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10706)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10706)/publications"},"_namespace":null},{"id":10707,"version":3,"created":1554932662000,"modified":1555039596000,"deprecated":false,"name":"Ectoderm-neural cortex protein 1","accession":"O14682","gene":"ENC1","description":"Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0625488119110806,"antibodyCount":220,"monoclonalCount":54,"pubmedCount":null,"jensenScore":116.53338,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":36.9649142379147,"pubTatorScore":1.5532033458376568,"self":"https://pharos.nih.gov/idg/api/v1/targets(10707)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(10707)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(10707)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10707)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10707)/publications"},"_namespace":null},{"id":10708,"version":2,"created":1554932667000,"modified":1554932669000,"deprecated":false,"name":"Zinc finger protein 691","accession":"Q5VV52","gene":"ZNF691","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":104,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.395366548775137,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(10708)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":298,"href":"https://pharos.nih.gov/idg/api/v1/targets(10708)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(10708)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10708)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10708)/publications"},"_namespace":null},{"id":10709,"version":2,"created":1554932669000,"modified":1554932672000,"deprecated":false,"name":"Sodium-dependent phosphate transport protein 2A","accession":"Q06495","gene":"SLC34A1","description":"Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.983445901726238,"antibodyCount":65,"monoclonalCount":20,"pubmedCount":null,"jensenScore":87.106103,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.18226755230084,"pubTatorScore":1.8068441738810177,"self":"https://pharos.nih.gov/idg/api/v1/targets(10709)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(10709)/properties"},"_links":{"count":578,"href":"https://pharos.nih.gov/idg/api/v1/targets(10709)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10709)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10709)/publications"},"_namespace":null},{"id":10710,"version":2,"created":1554932673000,"modified":1554932676000,"deprecated":false,"name":"NHL repeat-containing protein 3","accession":"Q5JS37","gene":"NHLRC3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.5952205667976569,"antibodyCount":87,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.253968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.193221101351693,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10710)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(10710)/properties"},"_links":{"count":884,"href":"https://pharos.nih.gov/idg/api/v1/targets(10710)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10710)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10710)/publications"},"_namespace":null},{"id":10711,"version":2,"created":1554932677000,"modified":1554932681000,"deprecated":false,"name":"Cytoplasmic polyadenylation element-binding protein 4","accession":"Q17RY0","gene":"CPEB4","description":"Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.530407558281562,"antibodyCount":114,"monoclonalCount":1,"pubmedCount":null,"jensenScore":33.806775,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":38.758679331614445,"pubTatorScore":1.2589556805225264,"self":"https://pharos.nih.gov/idg/api/v1/targets(10711)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10711)/properties"},"_links":{"count":1028,"href":"https://pharos.nih.gov/idg/api/v1/targets(10711)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10711)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(10711)/publications"},"_namespace":null},{"id":10712,"version":2,"created":1554932682000,"modified":1554932687000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DRB1-8 beta chain","accession":"Q30134","gene":"HLA-DRB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(10712)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2671,"href":"https://pharos.nih.gov/idg/api/v1/targets(10712)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10712)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10712)/synonyms"},"_publications":{"count":2530,"href":"https://pharos.nih.gov/idg/api/v1/targets(10712)/publications"},"_namespace":null},{"id":10713,"version":3,"created":1554932695000,"modified":1555039597000,"deprecated":false,"name":"ATP-binding cassette sub-family D member 4","accession":"O14678","gene":"ABCD4","description":"May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.2908561893546187,"antibodyCount":169,"monoclonalCount":2,"pubmedCount":null,"jensenScore":18.593514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.71296870337088,"pubTatorScore":1.11851639841661,"self":"https://pharos.nih.gov/idg/api/v1/targets(10713)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":315,"href":"https://pharos.nih.gov/idg/api/v1/targets(10713)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(10713)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10713)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10713)/publications"},"_namespace":null},{"id":10714,"version":2,"created":1554932699000,"modified":1554932702000,"deprecated":false,"name":"Lymphocyte antigen 6K","accession":"Q17RY6","gene":"LY6K","description":"Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth (PubMed:18089789).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6069838609128422,"antibodyCount":61,"monoclonalCount":27,"pubmedCount":null,"jensenScore":41.873337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.198124748842247,"pubTatorScore":1.2032142405615192,"self":"https://pharos.nih.gov/idg/api/v1/targets(10714)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10714)/properties"},"_links":{"count":779,"href":"https://pharos.nih.gov/idg/api/v1/targets(10714)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10714)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10714)/publications"},"_namespace":null},{"id":10715,"version":2,"created":1554932702000,"modified":1554932705000,"deprecated":false,"name":"Protein FAM98B","accession":"Q52LJ0","gene":"FAM98B","description":"Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.12979124045225707,"antibodyCount":81,"monoclonalCount":4,"pubmedCount":null,"jensenScore":0.707213,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.695145201511817,"pubTatorScore":-0.12493873660829995,"self":"https://pharos.nih.gov/idg/api/v1/targets(10715)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(10715)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(10715)/links"},"_synonyms":{"count":71,"href":"https://pharos.nih.gov/idg/api/v1/targets(10715)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10715)/publications"},"_namespace":null},{"id":10716,"version":2,"created":1554932706000,"modified":1554932711000,"deprecated":false,"name":"Amyloid-like protein 2","accession":"Q06481","gene":"APLP2","description":"May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0476784188473687,"antibodyCount":279,"monoclonalCount":18,"pubmedCount":null,"jensenScore":101.328517,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.93668118808506,"pubTatorScore":1.9249844779434633,"self":"https://pharos.nih.gov/idg/api/v1/targets(10716)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":495,"href":"https://pharos.nih.gov/idg/api/v1/targets(10716)/properties"},"_links":{"count":1250,"href":"https://pharos.nih.gov/idg/api/v1/targets(10716)/links"},"_synonyms":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(10716)/synonyms"},"_publications":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10716)/publications"},"_namespace":null},{"id":10717,"version":2,"created":1554932712000,"modified":1554932715000,"deprecated":false,"name":"Mesoderm induction early response protein 3","accession":"Q7Z3K6","gene":"MIER3","description":"Transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.36172783471470943,"antibodyCount":90,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.968096,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.812720817839853,"pubTatorScore":-0.11539322987842283,"self":"https://pharos.nih.gov/idg/api/v1/targets(10717)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10717)/properties"},"_links":{"count":860,"href":"https://pharos.nih.gov/idg/api/v1/targets(10717)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10717)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10717)/publications"},"_namespace":null},{"id":10718,"version":2,"created":1554932715000,"modified":1554932716000,"deprecated":false,"name":"Uncharacterized protein C1orf232","accession":"A0A0U1RR37","gene":"C1orf232","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10718)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10718)/properties"},"_links":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10718)/links"},"_synonyms":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10718)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10718)/publications"},"_namespace":null},{"id":10719,"version":2,"created":1554932716000,"modified":1554932720000,"deprecated":false,"name":"Pogo transposable element with ZNF domain","accession":"Q7Z3K3","gene":"POGZ","description":"Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9704612433697722,"antibodyCount":102,"monoclonalCount":4,"pubmedCount":null,"jensenScore":8.509115,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.301358144910495,"pubTatorScore":0.6931404313310722,"self":"https://pharos.nih.gov/idg/api/v1/targets(10719)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":425,"href":"https://pharos.nih.gov/idg/api/v1/targets(10719)/properties"},"_links":{"count":1240,"href":"https://pharos.nih.gov/idg/api/v1/targets(10719)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(10719)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10719)/publications"},"_namespace":null},{"id":10720,"version":2,"created":1554932721000,"modified":1554932724000,"deprecated":false,"name":"Transcription elongation factor A protein-like 2","accession":"Q9H3H9","gene":"TCEAL2","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.128230643161771,"antibodyCount":80,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.264516,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.07433061265028,"pubTatorScore":-0.02848850836774482,"self":"https://pharos.nih.gov/idg/api/v1/targets(10720)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(10720)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(10720)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10720)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10720)/publications"},"_namespace":null},{"id":10721,"version":3,"created":1554932726000,"modified":1554932947000,"deprecated":false,"name":"Prostaglandin E synthase","accession":"O14684","gene":"PTGES","description":"Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-3.054029459739225,"antibodyCount":151,"monoclonalCount":11,"pubmedCount":null,"jensenScore":1164.18119,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.3594340068078,"pubTatorScore":2.300717162764337,"self":"https://pharos.nih.gov/idg/api/v1/targets(10721)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(10721)/properties"},"_links":{"count":1628,"href":"https://pharos.nih.gov/idg/api/v1/targets(10721)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10721)/synonyms"},"_publications":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10721)/publications"},"_namespace":null},{"id":10722,"version":2,"created":1554932950000,"modified":1554932950000,"deprecated":false,"name":"Protein PAPPAS","accession":"Q5QFB9","gene":"PAPPA-AS1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":1.629443623325641,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10722)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10722)/properties"},"_links":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10722)/links"},"_synonyms":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10722)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10722)/publications"},"_namespace":null},{"id":10723,"version":2,"created":1554932950000,"modified":1554932951000,"deprecated":false,"name":"Protein phosphatase inhibitor 2-like protein 3","accession":"Q6NXS1","gene":"PPP1R2B","description":"Inhibitor of protein-phosphatase 1.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.2052289524868685,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.245125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.07918141976545234,"self":"https://pharos.nih.gov/idg/api/v1/targets(10723)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(10723)/properties"},"_links":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(10723)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10723)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10723)/publications"},"_namespace":null},{"id":10724,"version":2,"created":1554932951000,"modified":1554932957000,"deprecated":false,"name":"Histone-lysine N-methyltransferase 2D","accession":"O14686","gene":"KMT2D","description":"Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.080863307984809,"antibodyCount":133,"monoclonalCount":9,"pubmedCount":null,"jensenScore":118.133705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.302502147155636,"pubTatorScore":1.9998410625696952,"self":"https://pharos.nih.gov/idg/api/v1/targets(10724)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":513,"href":"https://pharos.nih.gov/idg/api/v1/targets(10724)/properties"},"_links":{"count":1247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10724)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10724)/synonyms"},"_publications":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10724)/publications"},"_namespace":null},{"id":10725,"version":3,"created":1554932958000,"modified":1555039598000,"deprecated":false,"name":"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase","accession":"Q9H3H5","gene":"DPAGT1","description":"Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7669708743232375,"antibodyCount":136,"monoclonalCount":7,"pubmedCount":null,"jensenScore":571.214596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":38.08449752718761,"pubTatorScore":1.8063794864638392,"self":"https://pharos.nih.gov/idg/api/v1/targets(10725)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(10725)/properties"},"_links":{"count":1108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10725)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10725)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10725)/publications"},"_namespace":null},{"id":10726,"version":2,"created":1554932964000,"modified":1554932965000,"deprecated":false,"name":"RanBP2-like and GRIP domain-containing protein 4","accession":"Q7Z3J3","gene":"RGPD4","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.005139639693286,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.308824,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.623828337666936,"pubTatorScore":-0.2552721576678595,"self":"https://pharos.nih.gov/idg/api/v1/targets(10726)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(10726)/properties"},"_links":{"count":788,"href":"https://pharos.nih.gov/idg/api/v1/targets(10726)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10726)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10726)/publications"},"_namespace":null},{"id":10727,"version":2,"created":1554932966000,"modified":1554932969000,"deprecated":false,"name":"tRNA dimethylallyltransferase","accession":"Q9H3H1","gene":"TRIT1","description":"Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.361347039890841,"antibodyCount":69,"monoclonalCount":4,"pubmedCount":null,"jensenScore":237.302538,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.688482718394944,"pubTatorScore":2.3377752966823127,"self":"https://pharos.nih.gov/idg/api/v1/targets(10727)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(10727)/properties"},"_links":{"count":922,"href":"https://pharos.nih.gov/idg/api/v1/targets(10727)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10727)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10727)/publications"},"_namespace":null},{"id":10728,"version":2,"created":1554932970000,"modified":1554932973000,"deprecated":false,"name":"UPF0696 protein C11orf68","accession":"Q9H3H3","gene":"C11orf68","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2900346137511377,"antibodyCount":18,"monoclonalCount":1,"pubmedCount":null,"jensenScore":2.033334,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.22184883647524403,"self":"https://pharos.nih.gov/idg/api/v1/targets(10728)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10728)/properties"},"_links":{"count":965,"href":"https://pharos.nih.gov/idg/api/v1/targets(10728)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10728)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10728)/publications"},"_namespace":null},{"id":10729,"version":2,"created":1554932973000,"modified":1554932974000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 20A3","accession":"Q5VUR7","gene":"ANKRD20A3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":111,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.112997613844854,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10729)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10729)/properties"},"_links":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10729)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10729)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10729)/publications"},"_namespace":null},{"id":10730,"version":2,"created":1554932974000,"modified":1554932977000,"deprecated":false,"name":"Transmembrane anterior posterior transformation protein 1 homolog","accession":"Q6NXT6","gene":"TAPT1","description":"(Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4421436742661945,"antibodyCount":68,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.021825,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.655582767793643,"pubTatorScore":0.40369228041711436,"self":"https://pharos.nih.gov/idg/api/v1/targets(10730)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(10730)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(10730)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10730)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10730)/publications"},"_namespace":null},{"id":10731,"version":2,"created":1554932977000,"modified":1554932982000,"deprecated":false,"name":"Ras-specific guanine nucleotide-releasing factor RalGPS1","accession":"Q5JS13","gene":"RALGPS1","description":"Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.3010299956639812,"antibodyCount":40,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.922421,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.951765997591252,"pubTatorScore":0.6240318660134806,"self":"https://pharos.nih.gov/idg/api/v1/targets(10731)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10731)/properties"},"_links":{"count":830,"href":"https://pharos.nih.gov/idg/api/v1/targets(10731)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(10731)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10731)/publications"},"_namespace":null},{"id":10732,"version":3,"created":1554932983000,"modified":1555039600000,"deprecated":false,"name":"Probable tubulin polyglutamylase TTLL9","accession":"Q3SXZ7","gene":"TTLL9","description":"Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.6690067896444654,"antibodyCount":26,"monoclonalCount":3,"pubmedCount":null,"jensenScore":4.922222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":23.580272291267697,"pubTatorScore":0.5835765478692101,"self":"https://pharos.nih.gov/idg/api/v1/targets(10732)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":174,"href":"https://pharos.nih.gov/idg/api/v1/targets(10732)/properties"},"_links":{"count":756,"href":"https://pharos.nih.gov/idg/api/v1/targets(10732)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10732)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10732)/publications"},"_namespace":null},{"id":10733,"version":2,"created":1554932986000,"modified":1554932990000,"deprecated":false,"name":"UPF0505 protein C16orf62","accession":"Q7Z3J2","gene":"VPS35L","description":"Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.007348063546608023,"antibodyCount":29,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.720065,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.11203461602850755,"self":"https://pharos.nih.gov/idg/api/v1/targets(10733)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(10733)/properties"},"_links":{"count":933,"href":"https://pharos.nih.gov/idg/api/v1/targets(10733)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10733)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10733)/publications"},"_namespace":null},{"id":10734,"version":2,"created":1554932991000,"modified":1554932991000,"deprecated":false,"name":"Zinc finger protein 718","accession":"Q3SXZ3","gene":"ZNF718","description":"May be involved in transcriptional regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.75300458821609,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10734)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10734)/properties"},"_links":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10734)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10734)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10734)/publications"},"_namespace":null},{"id":10735,"version":3,"created":1554932991000,"modified":1555039601000,"deprecated":false,"name":"Zinc transporter 6","accession":"Q6NXT4","gene":"SLC30A6","description":"Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-1.0382533308705628,"antibodyCount":99,"monoclonalCount":6,"pubmedCount":null,"jensenScore":9.801917,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":31.769205591388932,"pubTatorScore":0.8689754690910401,"self":"https://pharos.nih.gov/idg/api/v1/targets(10735)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":272,"href":"https://pharos.nih.gov/idg/api/v1/targets(10735)/properties"},"_links":{"count":992,"href":"https://pharos.nih.gov/idg/api/v1/targets(10735)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10735)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10735)/publications"},"_namespace":null},{"id":10736,"version":2,"created":1554932995000,"modified":1554932998000,"deprecated":false,"name":"Ankyrin repeat domain-containing protein 54","accession":"Q6NXT1","gene":"ANKRD54","description":"Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5399270477294345,"antibodyCount":95,"monoclonalCount":0,"pubmedCount":null,"jensenScore":34.661992,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.579585946639195,"pubTatorScore":1.3050185121505493,"self":"https://pharos.nih.gov/idg/api/v1/targets(10736)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":346,"href":"https://pharos.nih.gov/idg/api/v1/targets(10736)/properties"},"_links":{"count":903,"href":"https://pharos.nih.gov/idg/api/v1/targets(10736)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10736)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10736)/publications"},"_namespace":null},{"id":10737,"version":2,"created":1554932999000,"modified":1554933001000,"deprecated":false,"name":"Histone H3.3C","accession":"Q6NXT2","gene":"H3F3C","description":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0969100130080565,"antibodyCount":17,"monoclonalCount":6,"pubmedCount":null,"jensenScore":12.395811,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.32344609891914,"pubTatorScore":1.069421396420557,"self":"https://pharos.nih.gov/idg/api/v1/targets(10737)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(10737)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(10737)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10737)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10737)/publications"},"_namespace":null},{"id":10738,"version":3,"created":1554933002000,"modified":1555039602000,"deprecated":false,"name":"Probable serine carboxypeptidase CPVL","accession":"Q9H3G5","gene":"CPVL","description":"May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8940033373546612,"antibodyCount":135,"monoclonalCount":36,"pubmedCount":null,"jensenScore":74.359951,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":32.03245630827476,"pubTatorScore":1.1108866459915976,"self":"https://pharos.nih.gov/idg/api/v1/targets(10738)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(10738)/properties"},"_links":{"count":951,"href":"https://pharos.nih.gov/idg/api/v1/targets(10738)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10738)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10738)/publications"},"_namespace":null},{"id":10739,"version":3,"created":1554933006000,"modified":1555039603000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DR beta 5 chain","accession":"Q30154","gene":"HLA-DRB5","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.6361436807049317,"antibodyCount":97,"monoclonalCount":7,"pubmedCount":null,"jensenScore":462.90845,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":31.477610501129153,"pubTatorScore":2.4283265413217716,"self":"https://pharos.nih.gov/idg/api/v1/targets(10739)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":492,"href":"https://pharos.nih.gov/idg/api/v1/targets(10739)/properties"},"_links":{"count":994,"href":"https://pharos.nih.gov/idg/api/v1/targets(10739)/links"},"_synonyms":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(10739)/synonyms"},"_publications":{"count":178,"href":"https://pharos.nih.gov/idg/api/v1/targets(10739)/publications"},"_namespace":null},{"id":10740,"version":2,"created":1554933011000,"modified":1554933014000,"deprecated":false,"name":"Serine/threonine-protein kinase H1","accession":"P11801","gene":"PSKH1","description":"May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.","idgFamily":"Kinase","idgTDL":"Tdark","novelty":-0.4782165791763859,"antibodyCount":97,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.111146,"patentCount":959,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.21454027382427,"pubTatorScore":0.8061799739838872,"self":"https://pharos.nih.gov/idg/api/v1/targets(10740)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":363,"href":"https://pharos.nih.gov/idg/api/v1/targets(10740)/properties"},"_links":{"count":949,"href":"https://pharos.nih.gov/idg/api/v1/targets(10740)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10740)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10740)/publications"},"_namespace":null},{"id":10741,"version":4,"created":1554933015000,"modified":1555039608000,"deprecated":false,"name":"Cyclin-dependent kinase 4","accession":"P11802","gene":"CDK4","description":"Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-3.2487825024401817,"antibodyCount":803,"monoclonalCount":359,"pubmedCount":null,"jensenScore":1546.298384,"patentCount":105686,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":58.70565613611942,"pubTatorScore":3.029227487570653,"self":"https://pharos.nih.gov/idg/api/v1/targets(10741)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":883,"href":"https://pharos.nih.gov/idg/api/v1/targets(10741)/properties"},"_links":{"count":1924,"href":"https://pharos.nih.gov/idg/api/v1/targets(10741)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10741)/synonyms"},"_publications":{"count":367,"href":"https://pharos.nih.gov/idg/api/v1/targets(10741)/publications"},"_namespace":null},{"id":10742,"version":2,"created":1554933128000,"modified":1554933131000,"deprecated":false,"name":"SUZ domain-containing protein 1","accession":"Q7Z422","gene":"SZRD1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.6020599913279624,"antibodyCount":121,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.727273,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.841743828901432,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10742)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":228,"href":"https://pharos.nih.gov/idg/api/v1/targets(10742)/properties"},"_links":{"count":950,"href":"https://pharos.nih.gov/idg/api/v1/targets(10742)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10742)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10742)/publications"},"_namespace":null},{"id":10743,"version":3,"created":1554933132000,"modified":1555039612000,"deprecated":false,"name":"Lck-interacting transmembrane adapter 1","accession":"Q9H400","gene":"LIME1","description":"Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.15634719999133512,"antibodyCount":229,"monoclonalCount":113,"pubmedCount":null,"jensenScore":1.303448,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":26.64262792089264,"pubTatorScore":1.0937967325922526,"self":"https://pharos.nih.gov/idg/api/v1/targets(10743)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(10743)/properties"},"_links":{"count":901,"href":"https://pharos.nih.gov/idg/api/v1/targets(10743)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10743)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10743)/publications"},"_namespace":null},{"id":10744,"version":2,"created":1554933135000,"modified":1554933138000,"deprecated":false,"name":"Protein lifeguard 1","accession":"Q7Z429","gene":"GRINA","description":"Potential apoptotic regulator.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9190365606092107,"antibodyCount":147,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.296413,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.22159119881098,"pubTatorScore":0.7888751157754168,"self":"https://pharos.nih.gov/idg/api/v1/targets(10744)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(10744)/properties"},"_links":{"count":998,"href":"https://pharos.nih.gov/idg/api/v1/targets(10744)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10744)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10744)/publications"},"_namespace":null},{"id":10745,"version":2,"created":1554933139000,"modified":1554933140000,"deprecated":false,"name":"Homeobox protein CDX-4","accession":"O14627","gene":"CDX4","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.4934074410481173,"antibodyCount":209,"monoclonalCount":103,"pubmedCount":null,"jensenScore":29.362414,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.60627007594582,"pubTatorScore":1.254697673886226,"self":"https://pharos.nih.gov/idg/api/v1/targets(10745)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":125,"href":"https://pharos.nih.gov/idg/api/v1/targets(10745)/properties"},"_links":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(10745)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10745)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10745)/publications"},"_namespace":null},{"id":10746,"version":2,"created":1554933140000,"modified":1554933144000,"deprecated":false,"name":"Probable G-protein coupled receptor 171","accession":"O14626","gene":"GPR171","description":"Orphan receptor.","idgFamily":"GPCR","idgTDL":"Tdark","novelty":-0.528092702178993,"antibodyCount":245,"monoclonalCount":2,"pubmedCount":null,"jensenScore":3.874767,"patentCount":1931,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.685556582787978,"pubTatorScore":-0.09755650699908781,"self":"https://pharos.nih.gov/idg/api/v1/targets(10746)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(10746)/properties"},"_links":{"count":747,"href":"https://pharos.nih.gov/idg/api/v1/targets(10746)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10746)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10746)/publications"},"_namespace":null},{"id":10747,"version":2,"created":1554933145000,"modified":1554933148000,"deprecated":false,"name":"Zinc finger protein 195","accession":"O14628","gene":"ZNF195","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.6023979170123284,"antibodyCount":90,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.609616,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.508627197360273,"pubTatorScore":1.0530784434834197,"self":"https://pharos.nih.gov/idg/api/v1/targets(10747)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":263,"href":"https://pharos.nih.gov/idg/api/v1/targets(10747)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(10747)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10747)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10747)/publications"},"_namespace":null},{"id":10748,"version":2,"created":1554933149000,"modified":1554933154000,"deprecated":false,"name":"HLA class II histocompatibility antigen, DRB1-10 beta chain","accession":"Q30167","gene":"HLA-DRB1","description":"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":3.706359650038726,"self":"https://pharos.nih.gov/idg/api/v1/targets(10748)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2665,"href":"https://pharos.nih.gov/idg/api/v1/targets(10748)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10748)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10748)/synonyms"},"_publications":{"count":2530,"href":"https://pharos.nih.gov/idg/api/v1/targets(10748)/publications"},"_namespace":null},{"id":10749,"version":3,"created":1554933162000,"modified":1555039613000,"deprecated":false,"name":"C-X-C motif chemokine 11","accession":"O14625","gene":"CXCL11","description":"Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.7349910350754936,"antibodyCount":403,"monoclonalCount":100,"pubmedCount":null,"jensenScore":520.223029,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":29.610936828940694,"pubTatorScore":2.5244132533524697,"self":"https://pharos.nih.gov/idg/api/v1/targets(10749)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":342,"href":"https://pharos.nih.gov/idg/api/v1/targets(10749)/properties"},"_links":{"count":863,"href":"https://pharos.nih.gov/idg/api/v1/targets(10749)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10749)/synonyms"},"_publications":{"count":102,"href":"https://pharos.nih.gov/idg/api/v1/targets(10749)/publications"},"_namespace":null},{"id":10750,"version":3,"created":1554933167000,"modified":1554933316000,"deprecated":false,"name":"Histamine H4 receptor","accession":"Q9H3N8","gene":"HRH4","description":"The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).","idgFamily":"GPCR","idgTDL":"Tchem","novelty":-2.397384467205938,"antibodyCount":190,"monoclonalCount":7,"pubmedCount":null,"jensenScore":263.644435,"patentCount":21522,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.758549499816144,"pubTatorScore":2.166079751209233,"self":"https://pharos.nih.gov/idg/api/v1/targets(10750)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":317,"href":"https://pharos.nih.gov/idg/api/v1/targets(10750)/properties"},"_links":{"count":1361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10750)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10750)/synonyms"},"_publications":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10750)/publications"},"_namespace":null},{"id":10751,"version":2,"created":1554933319000,"modified":1554933323000,"deprecated":false,"name":"E3 ubiquitin-protein ligase RNF144B","accession":"Q7Z419","gene":"RNF144B","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.436351992497978,"antibodyCount":245,"monoclonalCount":133,"pubmedCount":null,"jensenScore":26.6375,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.431732198767556,"pubTatorScore":1.108661680704142,"self":"https://pharos.nih.gov/idg/api/v1/targets(10751)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(10751)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(10751)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10751)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10751)/publications"},"_namespace":null},{"id":10752,"version":2,"created":1554933324000,"modified":1554933329000,"deprecated":false,"name":"Peroxisome assembly protein 26","accession":"Q7Z412","gene":"PEX26","description":"Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0482937789198619,"antibodyCount":85,"monoclonalCount":2,"pubmedCount":null,"jensenScore":11.805037,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.60091776296102,"pubTatorScore":0.9633942348934181,"self":"https://pharos.nih.gov/idg/api/v1/targets(10752)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":366,"href":"https://pharos.nih.gov/idg/api/v1/targets(10752)/properties"},"_links":{"count":1080,"href":"https://pharos.nih.gov/idg/api/v1/targets(10752)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10752)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10752)/publications"},"_namespace":null},{"id":10753,"version":3,"created":1554933330000,"modified":1555039614000,"deprecated":false,"name":"Transmembrane protein 255A","accession":"Q5JRV8","gene":"TMEM255A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":59,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":20.224498584594457,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10753)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":183,"href":"https://pharos.nih.gov/idg/api/v1/targets(10753)/properties"},"_links":{"count":766,"href":"https://pharos.nih.gov/idg/api/v1/targets(10753)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10753)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10753)/publications"},"_namespace":null},{"id":10754,"version":3,"created":1554933333000,"modified":1555039616000,"deprecated":false,"name":"Thioredoxin-related transmembrane protein 1","accession":"Q9H3N1","gene":"TMX1","description":"May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7562738297875364,"antibodyCount":204,"monoclonalCount":83,"pubmedCount":null,"jensenScore":58.453526,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":40.58902254801161,"pubTatorScore":1.2528819021114759,"self":"https://pharos.nih.gov/idg/api/v1/targets(10754)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":362,"href":"https://pharos.nih.gov/idg/api/v1/targets(10754)/properties"},"_links":{"count":1039,"href":"https://pharos.nih.gov/idg/api/v1/targets(10754)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10754)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10754)/publications"},"_namespace":null},{"id":10755,"version":2,"created":1554933338000,"modified":1554933345000,"deprecated":false,"name":"Protein CBFA2T1","accession":"Q06455","gene":"RUNX1T1","description":"Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.8810544319084737,"antibodyCount":168,"monoclonalCount":19,"pubmedCount":null,"jensenScore":689.496709,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.93365717799217,"pubTatorScore":2.675533757691991,"self":"https://pharos.nih.gov/idg/api/v1/targets(10755)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":459,"href":"https://pharos.nih.gov/idg/api/v1/targets(10755)/properties"},"_links":{"count":1165,"href":"https://pharos.nih.gov/idg/api/v1/targets(10755)/links"},"_synonyms":{"count":245,"href":"https://pharos.nih.gov/idg/api/v1/targets(10755)/synonyms"},"_publications":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(10755)/publications"},"_namespace":null},{"id":10756,"version":2,"created":1554933346000,"modified":1554933359000,"deprecated":false,"name":"Potassium channel subfamily K member 18","accession":"Q7Z418","gene":"KCNK18","description":"Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.7886869268115573,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":66.53998,"patentCount":1916,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.665166898354668,"pubTatorScore":1.5264871966798983,"self":"https://pharos.nih.gov/idg/api/v1/targets(10756)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10756)/properties"},"_links":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10756)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10756)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10756)/publications"},"_namespace":null},{"id":10757,"version":3,"created":1554933360000,"modified":1555039617000,"deprecated":false,"name":"Nuclear fragile X mental retardation-interacting protein 2","accession":"Q7Z417","gene":"NUFIP2","description":"Binds RNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8013329078955468,"antibodyCount":70,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.618727,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":38.058376674277135,"pubTatorScore":1.7541354104127886,"self":"https://pharos.nih.gov/idg/api/v1/targets(10757)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(10757)/properties"},"_links":{"count":983,"href":"https://pharos.nih.gov/idg/api/v1/targets(10757)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10757)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10757)/publications"},"_namespace":null},{"id":10758,"version":2,"created":1554933365000,"modified":1554933368000,"deprecated":false,"name":"Ectonucleotide pyrophosphatase/phosphodiesterase family member 3","accession":"O14638","gene":"ENPP3","description":"Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.6306932101033396,"antibodyCount":315,"monoclonalCount":137,"pubmedCount":null,"jensenScore":396.730471,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.155300958408095,"pubTatorScore":2.479169814922008,"self":"https://pharos.nih.gov/idg/api/v1/targets(10758)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":301,"href":"https://pharos.nih.gov/idg/api/v1/targets(10758)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(10758)/links"},"_synonyms":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10758)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10758)/publications"},"_namespace":null},{"id":10759,"version":2,"created":1554933368000,"modified":1554933371000,"deprecated":false,"name":"Arylacetamide deacetylase-like 3","accession":"Q5VUY0","gene":"AADACL3","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.0,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.138662094670492,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10759)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10759)/properties"},"_links":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(10759)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10759)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10759)/publications"},"_namespace":null},{"id":10760,"version":3,"created":1554933371000,"modified":1555039619000,"deprecated":false,"name":"Actin-binding LIM protein 1","accession":"O14639","gene":"ABLIM1","description":"May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0594288830626597,"antibodyCount":127,"monoclonalCount":32,"pubmedCount":null,"jensenScore":10.87778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":51.140058201890625,"pubTatorScore":0.9419863129372626,"self":"https://pharos.nih.gov/idg/api/v1/targets(10760)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":434,"href":"https://pharos.nih.gov/idg/api/v1/targets(10760)/properties"},"_links":{"count":1168,"href":"https://pharos.nih.gov/idg/api/v1/targets(10760)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10760)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(10760)/publications"},"_namespace":null},{"id":10761,"version":2,"created":1554933377000,"modified":1554933380000,"deprecated":false,"name":"Solute carrier family 46 member 3","accession":"Q7Z3Q1","gene":"SLC46A3","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":-0.10833947435454379,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.325,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.618471391848445,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10761)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":226,"href":"https://pharos.nih.gov/idg/api/v1/targets(10761)/properties"},"_links":{"count":852,"href":"https://pharos.nih.gov/idg/api/v1/targets(10761)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10761)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10761)/publications"},"_namespace":null},{"id":10762,"version":2,"created":1554933381000,"modified":1554933383000,"deprecated":false,"name":"Arylacetamide deacetylase-like 4","accession":"Q5VUY2","gene":"AADACL4","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":73,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.835111206952908,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10762)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10762)/properties"},"_links":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(10762)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10762)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10762)/publications"},"_namespace":null},{"id":10763,"version":2,"created":1554933383000,"modified":1554933384000,"deprecated":false,"name":"Late cornified envelope protein 2B","accession":"O14633","gene":"LCE2B","description":"Precursors of the cornified envelope of the stratum corneum.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.2466723327623292,"antibodyCount":53,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.234834135054392,"pubTatorScore":0.6849269187967852,"self":"https://pharos.nih.gov/idg/api/v1/targets(10763)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10763)/properties"},"_links":{"count":387,"href":"https://pharos.nih.gov/idg/api/v1/targets(10763)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10763)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10763)/publications"},"_namespace":null},{"id":10764,"version":3,"created":1554933384000,"modified":1555039621000,"deprecated":false,"name":"Thioredoxin-interacting protein","accession":"Q9H3M7","gene":"TXNIP","description":"May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.4758259506771636,"antibodyCount":216,"monoclonalCount":26,"pubmedCount":null,"jensenScore":365.162513,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":42.73407705639358,"pubTatorScore":2.267973964625819,"self":"https://pharos.nih.gov/idg/api/v1/targets(10764)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(10764)/properties"},"_links":{"count":611,"href":"https://pharos.nih.gov/idg/api/v1/targets(10764)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10764)/synonyms"},"_publications":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(10764)/publications"},"_namespace":null},{"id":10765,"version":2,"created":1554933389000,"modified":1554933392000,"deprecated":false,"name":"CUB and sushi domain-containing protein 2","accession":"Q7Z408","gene":"CSMD2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5270977282589906,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.497763,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.55677520751308,"pubTatorScore":0.700349562220835,"self":"https://pharos.nih.gov/idg/api/v1/targets(10765)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(10765)/properties"},"_links":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(10765)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10765)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10765)/publications"},"_namespace":null},{"id":10766,"version":2,"created":1554933393000,"modified":1554933394000,"deprecated":false,"name":"Ataxin-3-like protein","accession":"Q9H3M9","gene":"ATXN3L","description":"Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.2850569684088117,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.652083,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.88722213700749,"pubTatorScore":-0.4771216890143615,"self":"https://pharos.nih.gov/idg/api/v1/targets(10766)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10766)/properties"},"_links":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10766)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10766)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10766)/publications"},"_namespace":null},{"id":10767,"version":2,"created":1554933394000,"modified":1554933397000,"deprecated":false,"name":"C-myc promoter-binding protein","accession":"Q7Z401","gene":"DENND4A","description":"Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.1995723530956438,"antibodyCount":27,"monoclonalCount":12,"pubmedCount":null,"jensenScore":1.326496,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.46483622154943,"pubTatorScore":0.9107132821096744,"self":"https://pharos.nih.gov/idg/api/v1/targets(10767)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":280,"href":"https://pharos.nih.gov/idg/api/v1/targets(10767)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(10767)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10767)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10767)/publications"},"_namespace":null},{"id":10768,"version":2,"created":1554933398000,"modified":1554933401000,"deprecated":false,"name":"Attractin-like protein 1","accession":"Q5VV63","gene":"ATRNL1","description":"May play a role in melanocortin signaling pathways that regulate energy homeostasis.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3832167554704519,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.520468,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.059498655321335,"pubTatorScore":0.41218039174864657,"self":"https://pharos.nih.gov/idg/api/v1/targets(10768)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":224,"href":"https://pharos.nih.gov/idg/api/v1/targets(10768)/properties"},"_links":{"count":854,"href":"https://pharos.nih.gov/idg/api/v1/targets(10768)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10768)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10768)/publications"},"_namespace":null},{"id":10769,"version":3,"created":1554933402000,"modified":1555039622000,"deprecated":false,"name":"Transmembrane channel-like protein 6","accession":"Q7Z403","gene":"TMC6","description":"Probable ion channel.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-2.1880987256475253,"antibodyCount":115,"monoclonalCount":2,"pubmedCount":null,"jensenScore":151.529914,"patentCount":5150,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":36.41485171620778,"pubTatorScore":1.7025352542786276,"self":"https://pharos.nih.gov/idg/api/v1/targets(10769)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":296,"href":"https://pharos.nih.gov/idg/api/v1/targets(10769)/properties"},"_links":{"count":1021,"href":"https://pharos.nih.gov/idg/api/v1/targets(10769)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10769)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10769)/publications"},"_namespace":null},{"id":10770,"version":2,"created":1554933406000,"modified":1554933407000,"deprecated":false,"name":"Olfactory receptor 10J3","accession":"Q5JRS4","gene":"OR10J3","description":"Odorant receptor.","idgFamily":"oGPCR","idgTDL":"Tdark","novelty":1.1760912590556813,"antibodyCount":110,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.227273,"patentCount":122,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.144250770885415,"pubTatorScore":-1.230445447036316,"self":"https://pharos.nih.gov/idg/api/v1/targets(10770)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10770)/properties"},"_links":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10770)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10770)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10770)/publications"},"_namespace":null},{"id":10771,"version":3,"created":1554933408000,"modified":1555039623000,"deprecated":false,"name":"Transmembrane channel-like protein 7","accession":"Q7Z402","gene":"TMC7","description":"Probable ion channel.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.16421118128726012,"antibodyCount":42,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.46978,"patentCount":420,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":31.03988266229765,"pubTatorScore":-0.49291494284397114,"self":"https://pharos.nih.gov/idg/api/v1/targets(10771)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(10771)/properties"},"_links":{"count":818,"href":"https://pharos.nih.gov/idg/api/v1/targets(10771)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10771)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10771)/publications"},"_namespace":null},{"id":10772,"version":2,"created":1554933411000,"modified":1554933418000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily F member 1","accession":"Q9H3M0","gene":"KCNF1","description":"Putative voltage-gated potassium channel.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-1.82440527851483,"antibodyCount":121,"monoclonalCount":25,"pubmedCount":null,"jensenScore":62.651948,"patentCount":3478,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.927289830573844,"pubTatorScore":1.3360796299352997,"self":"https://pharos.nih.gov/idg/api/v1/targets(10772)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10772)/properties"},"_links":{"count":758,"href":"https://pharos.nih.gov/idg/api/v1/targets(10772)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10772)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10772)/publications"},"_namespace":null},{"id":10773,"version":2,"created":1554933419000,"modified":1554933422000,"deprecated":false,"name":"Transmembrane channel-like protein 4","accession":"Q7Z404","gene":"TMC4","description":"Probable ion channel.","idgFamily":"Ion Channel","idgTDL":"Tdark","novelty":-0.4445652172895838,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.758676,"patentCount":393,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.675278050275477,"pubTatorScore":0.014240719304508173,"self":"https://pharos.nih.gov/idg/api/v1/targets(10773)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(10773)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(10773)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10773)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10773)/publications"},"_namespace":null},{"id":10774,"version":2,"created":1554933423000,"modified":1554933426000,"deprecated":false,"name":"CUB and sushi domain-containing protein 3","accession":"Q7Z407","gene":"CSMD3","description":"Involved in dendrite development.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9174044686249576,"antibodyCount":50,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.873078,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.834402344629336,"pubTatorScore":0.8491883224033573,"self":"https://pharos.nih.gov/idg/api/v1/targets(10774)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":172,"href":"https://pharos.nih.gov/idg/api/v1/targets(10774)/properties"},"_links":{"count":737,"href":"https://pharos.nih.gov/idg/api/v1/targets(10774)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10774)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10774)/publications"},"_namespace":null},{"id":10775,"version":2,"created":1554933427000,"modified":1554933430000,"deprecated":false,"name":"Peroxisome proliferator-activated receptor gamma coactivator-related protein 1","accession":"Q5VV67","gene":"PPRC1","description":"Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.480903443653055,"antibodyCount":100,"monoclonalCount":0,"pubmedCount":null,"jensenScore":295.1214,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.47708622021277,"pubTatorScore":1.4474646900590733,"self":"https://pharos.nih.gov/idg/api/v1/targets(10775)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":371,"href":"https://pharos.nih.gov/idg/api/v1/targets(10775)/properties"},"_links":{"count":1011,"href":"https://pharos.nih.gov/idg/api/v1/targets(10775)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10775)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10775)/publications"},"_namespace":null},{"id":10776,"version":2,"created":1554933431000,"modified":1554933435000,"deprecated":false,"name":"Myosin-14","accession":"Q7Z406","gene":"MYH14","description":"Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4142912858337013,"antibodyCount":155,"monoclonalCount":43,"pubmedCount":null,"jensenScore":24.395798,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.818224513031225,"pubTatorScore":3.9057456139960025,"self":"https://pharos.nih.gov/idg/api/v1/targets(10776)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":419,"href":"https://pharos.nih.gov/idg/api/v1/targets(10776)/properties"},"_links":{"count":1084,"href":"https://pharos.nih.gov/idg/api/v1/targets(10776)/links"},"_synonyms":{"count":157,"href":"https://pharos.nih.gov/idg/api/v1/targets(10776)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10776)/publications"},"_namespace":null},{"id":10777,"version":4,"created":1554933436000,"modified":1555039624000,"deprecated":false,"name":"Potassium channel subfamily K member 3","accession":"O14649","gene":"KCNK3","description":"pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.456798927713406,"antibodyCount":114,"monoclonalCount":34,"pubmedCount":null,"jensenScore":291.117643,"patentCount":9414,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":36.50674843087659,"pubTatorScore":3.6125986706202533,"self":"https://pharos.nih.gov/idg/api/v1/targets(10777)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":328,"href":"https://pharos.nih.gov/idg/api/v1/targets(10777)/properties"},"_links":{"count":976,"href":"https://pharos.nih.gov/idg/api/v1/targets(10777)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10777)/synonyms"},"_publications":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10777)/publications"},"_namespace":null},{"id":10778,"version":2,"created":1554933488000,"modified":1554933491000,"deprecated":false,"name":"Transmembrane protease serine 9","accession":"Q7Z410","gene":"TMPRSS9","description":"Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.5625760733511996,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.503875,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.414557321915336,"pubTatorScore":0.5965970956264602,"self":"https://pharos.nih.gov/idg/api/v1/targets(10778)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":200,"href":"https://pharos.nih.gov/idg/api/v1/targets(10778)/properties"},"_links":{"count":729,"href":"https://pharos.nih.gov/idg/api/v1/targets(10778)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10778)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10778)/publications"},"_namespace":null},{"id":10779,"version":3,"created":1554933491000,"modified":1555039626000,"deprecated":false,"name":"Segment polarity protein dishevelled homolog DVL-2","accession":"O14641","gene":"DVL2","description":"Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8706324042770144,"antibodyCount":288,"monoclonalCount":43,"pubmedCount":null,"jensenScore":68.410982,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":44.62062098045664,"pubTatorScore":1.704728499020104,"self":"https://pharos.nih.gov/idg/api/v1/targets(10779)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":557,"href":"https://pharos.nih.gov/idg/api/v1/targets(10779)/properties"},"_links":{"count":1103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10779)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(10779)/synonyms"},"_publications":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10779)/publications"},"_namespace":null},{"id":10780,"version":3,"created":1554933497000,"modified":1555039627000,"deprecated":false,"name":"Segment polarity protein dishevelled homolog DVL-1","accession":"O14640","gene":"DVL1","description":"Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-2.1156136429488024,"antibodyCount":169,"monoclonalCount":3,"pubmedCount":null,"jensenScore":188.354176,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":45.47069915321834,"pubTatorScore":1.729113125022493,"self":"https://pharos.nih.gov/idg/api/v1/targets(10780)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":542,"href":"https://pharos.nih.gov/idg/api/v1/targets(10780)/properties"},"_links":{"count":1153,"href":"https://pharos.nih.gov/idg/api/v1/targets(10780)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10780)/synonyms"},"_publications":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10780)/publications"},"_namespace":null},{"id":10781,"version":2,"created":1554933502000,"modified":1554933503000,"deprecated":false,"name":"Histone H2B type F-M","accession":"P0C1H6","gene":"H2BFM","description":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.0791812460476249,"antibodyCount":43,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0625,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.125390207006213,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10781)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":171,"href":"https://pharos.nih.gov/idg/api/v1/targets(10781)/properties"},"_links":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10781)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10781)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10781)/publications"},"_namespace":null},{"id":10782,"version":2,"created":1554933504000,"modified":1554933506000,"deprecated":false,"name":"Axonemal dynein light intermediate polypeptide 1","accession":"O14645","gene":"DNALI1","description":"May play a dynamic role in flagellar motility.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4236358988887579,"antibodyCount":150,"monoclonalCount":6,"pubmedCount":null,"jensenScore":2.217832,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.05128806138266,"pubTatorScore":0.5787433594007966,"self":"https://pharos.nih.gov/idg/api/v1/targets(10782)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(10782)/properties"},"_links":{"count":877,"href":"https://pharos.nih.gov/idg/api/v1/targets(10782)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10782)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10782)/publications"},"_namespace":null},{"id":10783,"version":2,"created":1554933507000,"modified":1554933513000,"deprecated":false,"name":"Chromodomain-helicase-DNA-binding protein 2","accession":"O14647","gene":"CHD2","description":"DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.044670413738889,"antibodyCount":121,"monoclonalCount":3,"pubmedCount":null,"jensenScore":11.068182,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.16140883812663,"pubTatorScore":1.7257638490687983,"self":"https://pharos.nih.gov/idg/api/v1/targets(10783)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":435,"href":"https://pharos.nih.gov/idg/api/v1/targets(10783)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10783)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10783)/synonyms"},"_publications":{"count":37,"href":"https://pharos.nih.gov/idg/api/v1/targets(10783)/publications"},"_namespace":null},{"id":10784,"version":2,"created":1554933514000,"modified":1554933520000,"deprecated":false,"name":"Chromodomain-helicase-DNA-binding protein 1","accession":"O14646","gene":"CHD1","description":"ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-2.1447165296856276,"antibodyCount":122,"monoclonalCount":28,"pubmedCount":null,"jensenScore":148.26088,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.996514963961395,"pubTatorScore":1.7867917486317495,"self":"https://pharos.nih.gov/idg/api/v1/targets(10784)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/properties"},"_links":{"count":1069,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10784)/publications"},"_namespace":null},{"id":10785,"version":2,"created":1554933521000,"modified":1554933521000,"deprecated":false,"name":"Transcription factor SPT20 homolog-like 1","accession":"Q3ZLR7","gene":"SUPT20HL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.052404884202492,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10785)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/properties"},"_links":{"count":23,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10785)/publications"},"_namespace":null},{"id":10786,"version":3,"created":1554933521000,"modified":1555039629000,"deprecated":false,"name":"Voltage-dependent calcium channel gamma-1 subunit","accession":"Q06432","gene":"CACNG1","description":"This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-0.7561035176166496,"antibodyCount":144,"monoclonalCount":2,"pubmedCount":null,"jensenScore":5.287589,"patentCount":308,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":21.877694445343234,"pubTatorScore":0.9270605996025667,"self":"https://pharos.nih.gov/idg/api/v1/targets(10786)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(10786)/properties"},"_links":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(10786)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10786)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10786)/publications"},"_namespace":null},{"id":10787,"version":2,"created":1554933524000,"modified":1554933526000,"deprecated":false,"name":"Proteasome assembly chaperone 4","accession":"Q5JS54","gene":"PSMG4","description":"Chaperone protein which promotes assembly of the 20S proteasome.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.997095013410008,"antibodyCount":3,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.466031,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.806841385167722,"pubTatorScore":0.9111576087399766,"self":"https://pharos.nih.gov/idg/api/v1/targets(10787)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(10787)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(10787)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10787)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10787)/publications"},"_namespace":null},{"id":10788,"version":3,"created":1554933527000,"modified":1555039630000,"deprecated":false,"name":"Methylmalonic aciduria and homocystinuria type D protein, mitochondrial","accession":"Q9H3L0","gene":"MMADHC","description":"Involved in cobalamin metabolism (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin (PubMed:18385497, PubMed:24722857). Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin (PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4837510772787903,"antibodyCount":132,"monoclonalCount":18,"pubmedCount":null,"jensenScore":32.405861,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.9175332289961,"pubTatorScore":1.2588766533002014,"self":"https://pharos.nih.gov/idg/api/v1/targets(10788)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":331,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10788)/publications"},"_namespace":null},{"id":10789,"version":2,"created":1554933531000,"modified":1554933533000,"deprecated":false,"name":"Insulin receptor substrate 4","accession":"O14654","gene":"IRS4","description":"Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.6042933070549534,"antibodyCount":121,"monoclonalCount":66,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.170970092576674,"pubTatorScore":1.633807608107414,"self":"https://pharos.nih.gov/idg/api/v1/targets(10789)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/properties"},"_links":{"count":556,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10789)/publications"},"_namespace":null},{"id":10790,"version":3,"created":1554933534000,"modified":1555039631000,"deprecated":false,"name":"Golgi SNAP receptor complex member 2","accession":"O14653","gene":"GOSR2","description":"Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3504598250157989,"antibodyCount":88,"monoclonalCount":17,"pubmedCount":null,"jensenScore":17.942571,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":42.860091008745336,"pubTatorScore":1.3301736273531446,"self":"https://pharos.nih.gov/idg/api/v1/targets(10790)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":330,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/properties"},"_links":{"count":1096,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10790)/publications"},"_namespace":null},{"id":10791,"version":3,"created":1554933538000,"modified":1555039633000,"deprecated":false,"name":"Torsin-1A","accession":"O14656","gene":"TOR1A","description":"Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.100518751680266,"antibodyCount":179,"monoclonalCount":24,"pubmedCount":null,"jensenScore":1230.694044,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":43.95599820973205,"pubTatorScore":2.8808225146549806,"self":"https://pharos.nih.gov/idg/api/v1/targets(10791)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":597,"href":"https://pharos.nih.gov/idg/api/v1/targets(10791)/properties"},"_links":{"count":1317,"href":"https://pharos.nih.gov/idg/api/v1/targets(10791)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10791)/synonyms"},"_publications":{"count":176,"href":"https://pharos.nih.gov/idg/api/v1/targets(10791)/publications"},"_namespace":null},{"id":10792,"version":3,"created":1554933546000,"modified":1555039635000,"deprecated":false,"name":"Torsin-1B","accession":"O14657","gene":"TOR1B","description":"May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.0303702549243328,"antibodyCount":130,"monoclonalCount":0,"pubmedCount":null,"jensenScore":113.469023,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":37.192599078068895,"pubTatorScore":1.7811178076532366,"self":"https://pharos.nih.gov/idg/api/v1/targets(10792)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(10792)/properties"},"_links":{"count":1018,"href":"https://pharos.nih.gov/idg/api/v1/targets(10792)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10792)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10792)/publications"},"_namespace":null},{"id":10793,"version":3,"created":1554933551000,"modified":1555039636000,"deprecated":false,"name":"TCDD-inducible poly [ADP-ribose] polymerase","accession":"Q7Z3E1","gene":"TIPARP","description":"Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.4733932485713686,"antibodyCount":57,"monoclonalCount":2,"pubmedCount":null,"jensenScore":285.194018,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":42.14680156623081,"pubTatorScore":1.6758910328838863,"self":"https://pharos.nih.gov/idg/api/v1/targets(10793)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(10793)/properties"},"_links":{"count":879,"href":"https://pharos.nih.gov/idg/api/v1/targets(10793)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10793)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10793)/publications"},"_namespace":null},{"id":10794,"version":2,"created":1554933555000,"modified":1554933558000,"deprecated":false,"name":"Coiled-coil domain-containing protein 186","accession":"Q7Z3E2","gene":"CCDC186","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.8512583487190752,"antibodyCount":15,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.013514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.009597045094573,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10794)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":347,"href":"https://pharos.nih.gov/idg/api/v1/targets(10794)/properties"},"_links":{"count":993,"href":"https://pharos.nih.gov/idg/api/v1/targets(10794)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10794)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10794)/publications"},"_namespace":null},{"id":10795,"version":2,"created":1554933559000,"modified":1554933563000,"deprecated":false,"name":"LisH domain-containing protein ARMC9","accession":"Q7Z3E5","gene":"ARMC9","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5930221691316013,"antibodyCount":82,"monoclonalCount":0,"pubmedCount":null,"jensenScore":40.731545,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.837554017095023,"pubTatorScore":0.9669235099542054,"self":"https://pharos.nih.gov/idg/api/v1/targets(10795)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":365,"href":"https://pharos.nih.gov/idg/api/v1/targets(10795)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(10795)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10795)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10795)/publications"},"_namespace":null},{"id":10796,"version":3,"created":1554933563000,"modified":1555039638000,"deprecated":false,"name":"Developmental pluripotency-associated protein 3","accession":"Q6W0C5","gene":"DPPA3","description":"Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7476667349453379,"antibodyCount":105,"monoclonalCount":5,"pubmedCount":null,"jensenScore":48.860008,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":15.393518983368585,"pubTatorScore":2.150695081839241,"self":"https://pharos.nih.gov/idg/api/v1/targets(10796)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":147,"href":"https://pharos.nih.gov/idg/api/v1/targets(10796)/properties"},"_links":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(10796)/links"},"_synonyms":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10796)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10796)/publications"},"_namespace":null},{"id":10797,"version":3,"created":1554933565000,"modified":1555039639000,"deprecated":false,"name":"Protein FAM3B","accession":"P58499","gene":"FAM3B","description":"Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9498357041455814,"antibodyCount":201,"monoclonalCount":9,"pubmedCount":null,"jensenScore":97.726149,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":25.104546858309646,"pubTatorScore":1.9634263014179445,"self":"https://pharos.nih.gov/idg/api/v1/targets(10797)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":310,"href":"https://pharos.nih.gov/idg/api/v1/targets(10797)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(10797)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10797)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10797)/publications"},"_namespace":null},{"id":10798,"version":2,"created":1554933568000,"modified":1554933571000,"deprecated":false,"name":"V-type proton ATPase subunit S1-like protein","accession":"Q52LC2","gene":"ATP6AP1L","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.439533194166568,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10798)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(10798)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(10798)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10798)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10798)/publications"},"_namespace":null},{"id":10799,"version":3,"created":1554933571000,"modified":1555039641000,"deprecated":false,"name":"Tigger transposable element-derived protein 6","accession":"Q17RP2","gene":"TIGD6","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":1.4471580313422192,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.033333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":23.765028537602287,"pubTatorScore":-1.505149978319906,"self":"https://pharos.nih.gov/idg/api/v1/targets(10799)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":214,"href":"https://pharos.nih.gov/idg/api/v1/targets(10799)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(10799)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10799)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10799)/publications"},"_namespace":null},{"id":10800,"version":2,"created":1554933574000,"modified":1554933575000,"deprecated":false,"name":"Solute carrier family 25 member 52","accession":"Q3SY17","gene":"SLC25A52","description":null,"idgFamily":"Transporter","idgTDL":"Tdark","novelty":0.4357285699957319,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.325,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.859361713251543,"pubTatorScore":-0.5093056708330032,"self":"https://pharos.nih.gov/idg/api/v1/targets(10800)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10800)/properties"},"_links":{"count":480,"href":"https://pharos.nih.gov/idg/api/v1/targets(10800)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10800)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10800)/publications"},"_namespace":null},{"id":10801,"version":2,"created":1554933575000,"modified":1554933578000,"deprecated":false,"name":"Uncharacterized protein KIAA1644","accession":"Q3SXP7","gene":"SHISAL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.38021124171160603,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.285714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.4648869792587226,"self":"https://pharos.nih.gov/idg/api/v1/targets(10801)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(10801)/properties"},"_links":{"count":770,"href":"https://pharos.nih.gov/idg/api/v1/targets(10801)/links"},"_synonyms":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10801)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10801)/publications"},"_namespace":null},{"id":10802,"version":2,"created":1554933579000,"modified":1554933579000,"deprecated":false,"name":"Putative C-mannosyltransferase DPY19L2P1","accession":"Q6NXN4","gene":"DPY19L2P1","description":"Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.699423715731319,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10802)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10802)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10802)/links"},"_synonyms":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10802)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10802)/publications"},"_namespace":null},{"id":10803,"version":2,"created":1554933579000,"modified":1554933581000,"deprecated":false,"name":"LysM and putative peptidoglycan-binding domain-containing protein 3","accession":"Q7Z3D4","gene":"LYSMD3","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4357285699957319,"antibodyCount":28,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.294455,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.31024120411511,"pubTatorScore":-0.4423592820895424,"self":"https://pharos.nih.gov/idg/api/v1/targets(10803)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":324,"href":"https://pharos.nih.gov/idg/api/v1/targets(10803)/properties"},"_links":{"count":908,"href":"https://pharos.nih.gov/idg/api/v1/targets(10803)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10803)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10803)/publications"},"_namespace":null},{"id":10804,"version":2,"created":1554933582000,"modified":1554933585000,"deprecated":false,"name":"D-glutamate cyclase, mitochondrial","accession":"Q7Z3D6","gene":"DGLUCY","description":"D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10804)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(10804)/properties"},"_links":{"count":1124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10804)/links"},"_synonyms":{"count":142,"href":"https://pharos.nih.gov/idg/api/v1/targets(10804)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10804)/publications"},"_namespace":null},{"id":10805,"version":2,"created":1554933586000,"modified":1554933587000,"deprecated":false,"name":"Keratin-associated protein 13-3","accession":"Q3SY46","gene":"KRTAP13-3","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.4357285699957319,"antibodyCount":62,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.366667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":4.766565223513345,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(10805)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10805)/properties"},"_links":{"count":52,"href":"https://pharos.nih.gov/idg/api/v1/targets(10805)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10805)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10805)/publications"},"_namespace":null},{"id":10806,"version":2,"created":1554933587000,"modified":1554933589000,"deprecated":false,"name":"NTPase KAP family P-loop domain-containing protein 1","accession":"Q17RQ9","gene":"NKPD1","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.0,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.683544769023737,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10806)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(10806)/properties"},"_links":{"count":725,"href":"https://pharos.nih.gov/idg/api/v1/targets(10806)/links"},"_synonyms":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10806)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10806)/publications"},"_namespace":null},{"id":10807,"version":2,"created":1554933589000,"modified":1554933594000,"deprecated":false,"name":"Kinesin-1 heavy chain","accession":"P33176","gene":"KIF5B","description":"Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.3248497319275225,"antibodyCount":326,"monoclonalCount":95,"pubmedCount":null,"jensenScore":196.080438,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.9792302681377,"pubTatorScore":2.031478018517789,"self":"https://pharos.nih.gov/idg/api/v1/targets(10807)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":509,"href":"https://pharos.nih.gov/idg/api/v1/targets(10807)/properties"},"_links":{"count":1202,"href":"https://pharos.nih.gov/idg/api/v1/targets(10807)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10807)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10807)/publications"},"_namespace":null},{"id":10808,"version":2,"created":1554933595000,"modified":1554933596000,"deprecated":false,"name":"Thymosin beta-4, Y-chromosomal","accession":"O14604","gene":"TMSB4Y","description":"Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.3197794311658855,"antibodyCount":21,"monoclonalCount":9,"pubmedCount":null,"jensenScore":2.361905,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.644405859860134,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10808)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":190,"href":"https://pharos.nih.gov/idg/api/v1/targets(10808)/properties"},"_links":{"count":563,"href":"https://pharos.nih.gov/idg/api/v1/targets(10808)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10808)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10808)/publications"},"_namespace":null},{"id":10809,"version":2,"created":1554933597000,"modified":1554933600000,"deprecated":false,"name":"Histone demethylase UTY","accession":"O14607","gene":"UTY","description":"Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.","idgFamily":"Epigenetic","idgTDL":"Tbio","novelty":-1.5887258470837882,"antibodyCount":110,"monoclonalCount":6,"pubmedCount":null,"jensenScore":35.043968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.956812058113428,"pubTatorScore":1.1802543373376069,"self":"https://pharos.nih.gov/idg/api/v1/targets(10809)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(10809)/properties"},"_links":{"count":871,"href":"https://pharos.nih.gov/idg/api/v1/targets(10809)/links"},"_synonyms":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(10809)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10809)/publications"},"_namespace":null},{"id":10810,"version":2,"created":1554933601000,"modified":1554933601000,"deprecated":false,"name":"Testis-specific XK-related protein, Y-linked","accession":"O14609","gene":"XKRY","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":2.635647644725128,"pubTatorScore":0.22027915590490169,"self":"https://pharos.nih.gov/idg/api/v1/targets(10810)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10810)/properties"},"_links":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10810)/links"},"_synonyms":{"count":33,"href":"https://pharos.nih.gov/idg/api/v1/targets(10810)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10810)/publications"},"_namespace":null},{"id":10811,"version":2,"created":1554933601000,"modified":1554933605000,"deprecated":false,"name":"Pancreatic lipase-related protein 3","accession":"Q17RR3","gene":"PNLIPRP3","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":88,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.5,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.782146557646112,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10811)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10811)/properties"},"_links":{"count":383,"href":"https://pharos.nih.gov/idg/api/v1/targets(10811)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10811)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10811)/publications"},"_namespace":null},{"id":10812,"version":3,"created":1554933606000,"modified":1555039642000,"deprecated":false,"name":"Autophagy-related protein 9A","accession":"Q7Z3C6","gene":"ATG9A","description":"Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.444438482451881,"antibodyCount":279,"monoclonalCount":33,"pubmedCount":null,"jensenScore":25.873184,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":11,"knowledgeAvailability":34.2750949312614,"pubTatorScore":0.929197634626936,"self":"https://pharos.nih.gov/idg/api/v1/targets(10812)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":325,"href":"https://pharos.nih.gov/idg/api/v1/targets(10812)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10812)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10812)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10812)/publications"},"_namespace":null},{"id":10813,"version":2,"created":1554933610000,"modified":1554933610000,"deprecated":false,"name":"PTPN13-like protein, Y-linked","accession":"O14603","gene":"PRY","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.7725856225309276,"antibodyCount":11,"monoclonalCount":1,"pubmedCount":null,"jensenScore":43.013789,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.981189442801747,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10813)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":50,"href":"https://pharos.nih.gov/idg/api/v1/targets(10813)/properties"},"_links":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(10813)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10813)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10813)/publications"},"_namespace":null},{"id":10814,"version":3,"created":1554933610000,"modified":1555039643000,"deprecated":false,"name":"Eukaryotic translation initiation factor 1A, Y-chromosomal","accession":"O14602","gene":"EIF1AY","description":"Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.930679292610697,"antibodyCount":155,"monoclonalCount":40,"pubmedCount":null,"jensenScore":7.880204,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":22.012614004610732,"pubTatorScore":1.129590714821327,"self":"https://pharos.nih.gov/idg/api/v1/targets(10814)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":233,"href":"https://pharos.nih.gov/idg/api/v1/targets(10814)/properties"},"_links":{"count":848,"href":"https://pharos.nih.gov/idg/api/v1/targets(10814)/links"},"_synonyms":{"count":80,"href":"https://pharos.nih.gov/idg/api/v1/targets(10814)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10814)/publications"},"_namespace":null},{"id":10815,"version":2,"created":1554933614000,"modified":1554933617000,"deprecated":false,"name":"Leucine-rich repeat and calponin homology domain-containing protein 2","accession":"Q5VUJ6","gene":"LRCH2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":41,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.19143092760766,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10815)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":292,"href":"https://pharos.nih.gov/idg/api/v1/targets(10815)/properties"},"_links":{"count":885,"href":"https://pharos.nih.gov/idg/api/v1/targets(10815)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10815)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10815)/publications"},"_namespace":null},{"id":10816,"version":2,"created":1554933617000,"modified":1554933619000,"deprecated":false,"name":"Small integral membrane protein 15","accession":"Q7Z3B0","gene":"SMIM15","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.370661174404184,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10816)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10816)/properties"},"_links":{"count":774,"href":"https://pharos.nih.gov/idg/api/v1/targets(10816)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(10816)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10816)/publications"},"_namespace":null},{"id":10817,"version":2,"created":1554933620000,"modified":1554933620000,"deprecated":false,"name":"Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7","accession":"Q5VUJ5","gene":"AGAP7P","description":"Putative GTPase-activating protein.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.4357285699957319,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.385714,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.640059969840942,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(10817)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10817)/properties"},"_links":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10817)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10817)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10817)/publications"},"_namespace":null},{"id":10818,"version":3,"created":1554933620000,"modified":1555039644000,"deprecated":false,"name":"Neuronal growth regulator 1","accession":"Q7Z3B1","gene":"NEGR1","description":"May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8962482607069837,"antibodyCount":150,"monoclonalCount":14,"pubmedCount":null,"jensenScore":78.197916,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":33.85720971653275,"pubTatorScore":1.5548346410062068,"self":"https://pharos.nih.gov/idg/api/v1/targets(10818)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(10818)/properties"},"_links":{"count":926,"href":"https://pharos.nih.gov/idg/api/v1/targets(10818)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10818)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10818)/publications"},"_namespace":null},{"id":10819,"version":3,"created":1554933625000,"modified":1555039646000,"deprecated":false,"name":"Raftlin-2","accession":"Q52LD8","gene":"RFTN2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.21387982091017985,"antibodyCount":79,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.211111,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":6,"knowledgeAvailability":22.604557572252432,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10819)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":303,"href":"https://pharos.nih.gov/idg/api/v1/targets(10819)/properties"},"_links":{"count":939,"href":"https://pharos.nih.gov/idg/api/v1/targets(10819)/links"},"_synonyms":{"count":74,"href":"https://pharos.nih.gov/idg/api/v1/targets(10819)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10819)/publications"},"_namespace":null},{"id":10820,"version":2,"created":1554933629000,"modified":1554933630000,"deprecated":false,"name":"Uncharacterized protein C3orf36","accession":"Q3SXR2","gene":"C3orf36","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":55,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10820)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10820)/properties"},"_links":{"count":535,"href":"https://pharos.nih.gov/idg/api/v1/targets(10820)/links"},"_synonyms":{"count":47,"href":"https://pharos.nih.gov/idg/api/v1/targets(10820)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10820)/publications"},"_namespace":null},{"id":10821,"version":2,"created":1554933631000,"modified":1554933634000,"deprecated":false,"name":"Copper chaperone for superoxide dismutase","accession":"O14618","gene":"CCS","description":"Delivers copper to copper zinc superoxide dismutase (SOD1).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7618266396202293,"antibodyCount":209,"monoclonalCount":59,"pubmedCount":null,"jensenScore":50.668828,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.81715584179983,"pubTatorScore":1.702861153356101,"self":"https://pharos.nih.gov/idg/api/v1/targets(10821)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":402,"href":"https://pharos.nih.gov/idg/api/v1/targets(10821)/properties"},"_links":{"count":1042,"href":"https://pharos.nih.gov/idg/api/v1/targets(10821)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10821)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(10821)/publications"},"_namespace":null},{"id":10822,"version":2,"created":1554933635000,"modified":1554933638000,"deprecated":false,"name":"AP-3 complex subunit delta-1","accession":"O14617","gene":"AP3D1","description":"Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8946390678638958,"antibodyCount":56,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.424181,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.77338954208992,"pubTatorScore":0.7134719780780916,"self":"https://pharos.nih.gov/idg/api/v1/targets(10822)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":348,"href":"https://pharos.nih.gov/idg/api/v1/targets(10822)/properties"},"_links":{"count":1019,"href":"https://pharos.nih.gov/idg/api/v1/targets(10822)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10822)/synonyms"},"_publications":{"count":42,"href":"https://pharos.nih.gov/idg/api/v1/targets(10822)/publications"},"_namespace":null},{"id":10823,"version":3,"created":1554933639000,"modified":1555039647000,"deprecated":false,"name":"Coiled-coil domain-containing protein 158","accession":"Q5M9N0","gene":"CCDC158","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2632414311554608,"antibodyCount":64,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.670279,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":19.71850424220719,"pubTatorScore":-0.7781503817955484,"self":"https://pharos.nih.gov/idg/api/v1/targets(10823)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(10823)/properties"},"_links":{"count":765,"href":"https://pharos.nih.gov/idg/api/v1/targets(10823)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10823)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10823)/publications"},"_namespace":null},{"id":10824,"version":3,"created":1554933642000,"modified":1555039648000,"deprecated":false,"name":"Nucleoporin p54","accession":"Q7Z3B4","gene":"NUP54","description":"Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.7914734323792418,"antibodyCount":76,"monoclonalCount":1,"pubmedCount":null,"jensenScore":5.889257,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":34.172471167966194,"pubTatorScore":0.5209661632496955,"self":"https://pharos.nih.gov/idg/api/v1/targets(10824)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":397,"href":"https://pharos.nih.gov/idg/api/v1/targets(10824)/properties"},"_links":{"count":985,"href":"https://pharos.nih.gov/idg/api/v1/targets(10824)/links"},"_synonyms":{"count":139,"href":"https://pharos.nih.gov/idg/api/v1/targets(10824)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10824)/publications"},"_namespace":null},{"id":10825,"version":2,"created":1554933646000,"modified":1554933649000,"deprecated":false,"name":"EF-hand calcium-binding domain-containing protein 2","accession":"Q5VUJ9","gene":"EFCAB2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.02511072275450355,"antibodyCount":19,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.477778,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.45711028949632,"pubTatorScore":-0.8450984743089558,"self":"https://pharos.nih.gov/idg/api/v1/targets(10825)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(10825)/properties"},"_links":{"count":891,"href":"https://pharos.nih.gov/idg/api/v1/targets(10825)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10825)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10825)/publications"},"_namespace":null},{"id":10826,"version":3,"created":1554933650000,"modified":1555039649000,"deprecated":false,"name":"KAT8 regulatory NSL complex subunit 1","accession":"Q7Z3B3","gene":"KANSL1","description":"As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2714929025622437,"antibodyCount":36,"monoclonalCount":2,"pubmedCount":null,"jensenScore":17.871637,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":38.38648992823795,"pubTatorScore":1.128914461518916,"self":"https://pharos.nih.gov/idg/api/v1/targets(10826)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":436,"href":"https://pharos.nih.gov/idg/api/v1/targets(10826)/properties"},"_links":{"count":1115,"href":"https://pharos.nih.gov/idg/api/v1/targets(10826)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10826)/synonyms"},"_publications":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10826)/publications"},"_namespace":null},{"id":10827,"version":2,"created":1554933655000,"modified":1554933657000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2","accession":"O14610","gene":"GNGT2","description":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1697140958156034,"antibodyCount":55,"monoclonalCount":11,"pubmedCount":null,"jensenScore":13.569773,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.490991429981456,"pubTatorScore":0.7621781242816895,"self":"https://pharos.nih.gov/idg/api/v1/targets(10827)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":336,"href":"https://pharos.nih.gov/idg/api/v1/targets(10827)/properties"},"_links":{"count":780,"href":"https://pharos.nih.gov/idg/api/v1/targets(10827)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10827)/synonyms"},"_publications":{"count":17,"href":"https://pharos.nih.gov/idg/api/v1/targets(10827)/publications"},"_namespace":null},{"id":10828,"version":2,"created":1554933657000,"modified":1554933661000,"deprecated":false,"name":"Flap endonuclease GEN homolog 1","accession":"Q17RS7","gene":"GEN1","description":"Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.073252777897035,"antibodyCount":76,"monoclonalCount":0,"pubmedCount":null,"jensenScore":115.013048,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.406769183380845,"pubTatorScore":1.7958965619115188,"self":"https://pharos.nih.gov/idg/api/v1/targets(10828)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":253,"href":"https://pharos.nih.gov/idg/api/v1/targets(10828)/properties"},"_links":{"count":867,"href":"https://pharos.nih.gov/idg/api/v1/targets(10828)/links"},"_synonyms":{"count":97,"href":"https://pharos.nih.gov/idg/api/v1/targets(10828)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10828)/publications"},"_namespace":null},{"id":10829,"version":2,"created":1554933662000,"modified":1554933665000,"deprecated":false,"name":"Cdc42 effector protein 2","accession":"O14613","gene":"CDC42EP2","description":"Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4644277546699545,"antibodyCount":160,"monoclonalCount":24,"pubmedCount":null,"jensenScore":3.015452,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.84531001105089,"pubTatorScore":0.21278295226573554,"self":"https://pharos.nih.gov/idg/api/v1/targets(10829)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":351,"href":"https://pharos.nih.gov/idg/api/v1/targets(10829)/properties"},"_links":{"count":913,"href":"https://pharos.nih.gov/idg/api/v1/targets(10829)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10829)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10829)/publications"},"_namespace":null},{"id":10830,"version":2,"created":1554933666000,"modified":1554933668000,"deprecated":false,"name":"Zinc finger protein 572","accession":"Q7Z3I7","gene":"ZNF572","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":87,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.490408523274166,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10830)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":286,"href":"https://pharos.nih.gov/idg/api/v1/targets(10830)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(10830)/links"},"_synonyms":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10830)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10830)/publications"},"_namespace":null},{"id":10831,"version":3,"created":1554933669000,"modified":1555039650000,"deprecated":false,"name":"Mitochondrial 10-formyltetrahydrofolate dehydrogenase","accession":"Q3SY69","gene":"ALDH1L2","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9912547470234059,"antibodyCount":69,"monoclonalCount":3,"pubmedCount":null,"jensenScore":8.55103,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.329570358620405,"pubTatorScore":0.6556871054856173,"self":"https://pharos.nih.gov/idg/api/v1/targets(10831)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":259,"href":"https://pharos.nih.gov/idg/api/v1/targets(10831)/properties"},"_links":{"count":902,"href":"https://pharos.nih.gov/idg/api/v1/targets(10831)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10831)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10831)/publications"},"_namespace":null},{"id":10832,"version":2,"created":1554933673000,"modified":1554933674000,"deprecated":false,"name":"Keratin-associated protein 13-2","accession":"Q52LG2","gene":"KRTAP13-2","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":9.76947789468986,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10832)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10832)/properties"},"_links":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10832)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10832)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10832)/publications"},"_namespace":null},{"id":10833,"version":3,"created":1554933674000,"modified":1555039652000,"deprecated":false,"name":"Doublecortin domain-containing protein 2B","accession":"A2VCK2","gene":"DCDC2B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":28,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":12.500507958649896,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10833)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":163,"href":"https://pharos.nih.gov/idg/api/v1/targets(10833)/properties"},"_links":{"count":684,"href":"https://pharos.nih.gov/idg/api/v1/targets(10833)/links"},"_synonyms":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10833)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10833)/publications"},"_namespace":null},{"id":10834,"version":2,"created":1554933676000,"modified":1554933677000,"deprecated":false,"name":"Uncharacterized protein CXorf66","accession":"Q5JRM2","gene":"CXorf66","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6368220990348227,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.166667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10834)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10834)/properties"},"_links":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10834)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10834)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10834)/publications"},"_namespace":null},{"id":10835,"version":2,"created":1554933677000,"modified":1554933680000,"deprecated":false,"name":"BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3","accession":"Q9H3F6","gene":"KCTD10","description":"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8123031154216793,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":8.678221,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.223313631212925,"pubTatorScore":0.7501559565208612,"self":"https://pharos.nih.gov/idg/api/v1/targets(10835)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(10835)/properties"},"_links":{"count":987,"href":"https://pharos.nih.gov/idg/api/v1/targets(10835)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10835)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10835)/publications"},"_namespace":null},{"id":10836,"version":2,"created":1554933681000,"modified":1554933684000,"deprecated":false,"name":"OTU domain-containing protein 1","accession":"Q5VV17","gene":"OTUD1","description":"Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.520701822696472,"antibodyCount":68,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.661962,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":26.547142905792683,"pubTatorScore":0.5228787018508873,"self":"https://pharos.nih.gov/idg/api/v1/targets(10836)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":211,"href":"https://pharos.nih.gov/idg/api/v1/targets(10836)/properties"},"_links":{"count":827,"href":"https://pharos.nih.gov/idg/api/v1/targets(10836)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(10836)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10836)/publications"},"_namespace":null},{"id":10837,"version":2,"created":1554933684000,"modified":1554933685000,"deprecated":false,"name":"Forkhead box protein D4-like 5","accession":"Q5VV16","gene":"FOXD4L5","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.9542425094393249,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.288559203913388,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10837)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":169,"href":"https://pharos.nih.gov/idg/api/v1/targets(10837)/properties"},"_links":{"count":385,"href":"https://pharos.nih.gov/idg/api/v1/targets(10837)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10837)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10837)/publications"},"_namespace":null},{"id":10838,"version":3,"created":1554933686000,"modified":1555039653000,"deprecated":false,"name":"Sterile alpha motif domain-containing protein 7","accession":"Q7Z3H4","gene":"SAMD7","description":"Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.14870545954321132,"antibodyCount":108,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.915966,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":12.443899711758291,"pubTatorScore":-0.17609104190849456,"self":"https://pharos.nih.gov/idg/api/v1/targets(10838)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10838)/properties"},"_links":{"count":242,"href":"https://pharos.nih.gov/idg/api/v1/targets(10838)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10838)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10838)/publications"},"_namespace":null},{"id":10839,"version":3,"created":1554933687000,"modified":1555039653000,"deprecated":false,"name":"TELO2-interacting protein 2","accession":"Q6NXR4","gene":"TTI2","description":"Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7157441471915452,"antibodyCount":25,"monoclonalCount":0,"pubmedCount":null,"jensenScore":6.120619,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.290011998465086,"pubTatorScore":0.6829969383093918,"self":"https://pharos.nih.gov/idg/api/v1/targets(10839)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(10839)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(10839)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10839)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10839)/publications"},"_namespace":null},{"id":10840,"version":3,"created":1554933691000,"modified":1555039654000,"deprecated":false,"name":"Transcription factor Sp6","accession":"Q3SY56","gene":"SP6","description":"Promotes cell proliferation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.5568277934879338,"antibodyCount":117,"monoclonalCount":0,"pubmedCount":null,"jensenScore":339.577557,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":25.717674930836996,"pubTatorScore":2.5551794978525946,"self":"https://pharos.nih.gov/idg/api/v1/targets(10840)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":237,"href":"https://pharos.nih.gov/idg/api/v1/targets(10840)/properties"},"_links":{"count":810,"href":"https://pharos.nih.gov/idg/api/v1/targets(10840)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10840)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10840)/publications"},"_namespace":null},{"id":10841,"version":2,"created":1554933695000,"modified":1554933696000,"deprecated":false,"name":"Selenoprotein V","accession":"P59797","gene":"SELENOV","description":"May be involved in a redox-related process.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.9820485144601102,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":8.087826,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.4452413613694708,"self":"https://pharos.nih.gov/idg/api/v1/targets(10841)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10841)/properties"},"_links":{"count":541,"href":"https://pharos.nih.gov/idg/api/v1/targets(10841)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10841)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10841)/publications"},"_namespace":null},{"id":10842,"version":2,"created":1554933696000,"modified":1554933698000,"deprecated":false,"name":"Glutathione peroxidase 6","accession":"P59796","gene":"GPX6","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.6100247550091888,"antibodyCount":32,"monoclonalCount":7,"pubmedCount":null,"jensenScore":37.5365,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":15.733006010356409,"pubTatorScore":0.6170057959931773,"self":"https://pharos.nih.gov/idg/api/v1/targets(10842)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10842)/properties"},"_links":{"count":128,"href":"https://pharos.nih.gov/idg/api/v1/targets(10842)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10842)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10842)/publications"},"_namespace":null},{"id":10843,"version":3,"created":1554933698000,"modified":1555039655000,"deprecated":false,"name":"Zinc finger protein interacting with ribonucleoprotein K","accession":"Q3SY52","gene":"ZIK1","description":"May be a transcriptional repressor.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":-0.20080341889977169,"antibodyCount":85,"monoclonalCount":3,"pubmedCount":null,"jensenScore":1.700292,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":24.91375916358267,"pubTatorScore":0.028502931332889225,"self":"https://pharos.nih.gov/idg/api/v1/targets(10843)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":203,"href":"https://pharos.nih.gov/idg/api/v1/targets(10843)/properties"},"_links":{"count":792,"href":"https://pharos.nih.gov/idg/api/v1/targets(10843)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10843)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10843)/publications"},"_namespace":null},{"id":10844,"version":2,"created":1554933701000,"modified":1554933703000,"deprecated":false,"name":"Photoreceptor ankyrin repeat protein","accession":"Q7Z3H0","gene":"ANKRD33","description":"Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.17609125688420882,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.636364,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.027292803580576,"pubTatorScore":0.07918124604762482,"self":"https://pharos.nih.gov/idg/api/v1/targets(10844)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10844)/properties"},"_links":{"count":622,"href":"https://pharos.nih.gov/idg/api/v1/targets(10844)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10844)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10844)/publications"},"_namespace":null},{"id":10845,"version":2,"created":1554933703000,"modified":1554933703000,"deprecated":false,"name":"Putative UPF0633 protein ENSP00000303136","accession":"Q5VV11","gene":null,"description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10845)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10845)/properties"},"_links":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10845)/links"},"_synonyms":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10845)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10845)/publications"},"_namespace":null},{"id":10846,"version":2,"created":1554933703000,"modified":1554933704000,"deprecated":false,"name":"Coiled-coil domain-containing protein 162","accession":"A2VCL2","gene":"CCDC162P","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":7.511805816670354,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10846)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10846)/properties"},"_links":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10846)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10846)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10846)/publications"},"_namespace":null},{"id":10847,"version":3,"created":1554933704000,"modified":1555039656000,"deprecated":false,"name":"Interferon-inducible GTPase 5","accession":"Q6NXR0","gene":"IRGC","description":null,"idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.7206753345573897,"antibodyCount":138,"monoclonalCount":3,"pubmedCount":null,"jensenScore":502.768108,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":19.022601111402054,"pubTatorScore":0.9030899869919435,"self":"https://pharos.nih.gov/idg/api/v1/targets(10847)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10847)/properties"},"_links":{"count":590,"href":"https://pharos.nih.gov/idg/api/v1/targets(10847)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10847)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10847)/publications"},"_namespace":null},{"id":10848,"version":2,"created":1554933706000,"modified":1554933709000,"deprecated":false,"name":"Sorting nexin-25","accession":"Q9H3E2","gene":"SNX25","description":"May be involved in several stages of intracellular trafficking.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.47192005793175124,"antibodyCount":114,"monoclonalCount":11,"pubmedCount":null,"jensenScore":3.46562,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.484095678918145,"pubTatorScore":0.4617735128877733,"self":"https://pharos.nih.gov/idg/api/v1/targets(10848)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":231,"href":"https://pharos.nih.gov/idg/api/v1/targets(10848)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(10848)/links"},"_synonyms":{"count":89,"href":"https://pharos.nih.gov/idg/api/v1/targets(10848)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10848)/publications"},"_namespace":null},{"id":10849,"version":2,"created":1554933710000,"modified":1554933717000,"deprecated":false,"name":"Dynamin-1","accession":"Q05193","gene":"DNM1","description":"Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.676915047680837,"antibodyCount":464,"monoclonalCount":72,"pubmedCount":null,"jensenScore":450.03029,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.28672399499072,"pubTatorScore":2.0466275317903646,"self":"https://pharos.nih.gov/idg/api/v1/targets(10849)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":508,"href":"https://pharos.nih.gov/idg/api/v1/targets(10849)/properties"},"_links":{"count":1201,"href":"https://pharos.nih.gov/idg/api/v1/targets(10849)/links"},"_synonyms":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10849)/synonyms"},"_publications":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(10849)/publications"},"_namespace":null},{"id":10850,"version":3,"created":1554933718000,"modified":1555039657000,"deprecated":false,"name":"WD repeat-containing protein 25","accession":"Q64LD2","gene":"WDR25","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2021768277731961,"antibodyCount":60,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.346825,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.289838058947996,"pubTatorScore":0.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(10850)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":320,"href":"https://pharos.nih.gov/idg/api/v1/targets(10850)/properties"},"_links":{"count":880,"href":"https://pharos.nih.gov/idg/api/v1/targets(10850)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10850)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10850)/publications"},"_namespace":null},{"id":10851,"version":3,"created":1554933722000,"modified":1555039658000,"deprecated":false,"name":"Max dimerization protein 1","accession":"Q05195","gene":"MXD1","description":"Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.2273496156766928,"antibodyCount":142,"monoclonalCount":18,"pubmedCount":null,"jensenScore":13.961229,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":9,"knowledgeAvailability":40.95977007323409,"pubTatorScore":1.8274232462997366,"self":"https://pharos.nih.gov/idg/api/v1/targets(10851)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":398,"href":"https://pharos.nih.gov/idg/api/v1/targets(10851)/properties"},"_links":{"count":1012,"href":"https://pharos.nih.gov/idg/api/v1/targets(10851)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(10851)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10851)/publications"},"_namespace":null},{"id":10852,"version":2,"created":1554933727000,"modified":1554933727000,"deprecated":false,"name":"Elongin-A3 member B","accession":"Q3SY89","gene":"ELOA3B","description":"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.34678748579036184,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.2,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(10852)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10852)/properties"},"_links":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10852)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10852)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10852)/publications"},"_namespace":null},{"id":10853,"version":2,"created":1554933727000,"modified":1554933731000,"deprecated":false,"name":"Prickle-like protein 2","accession":"Q7Z3G6","gene":"PRICKLE2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.2281818384864867,"antibodyCount":44,"monoclonalCount":1,"pubmedCount":null,"jensenScore":15.47201,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.92207461387464,"pubTatorScore":0.7772084602095416,"self":"https://pharos.nih.gov/idg/api/v1/targets(10853)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":251,"href":"https://pharos.nih.gov/idg/api/v1/targets(10853)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10853)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10853)/synonyms"},"_publications":{"count":20,"href":"https://pharos.nih.gov/idg/api/v1/targets(10853)/publications"},"_namespace":null},{"id":10854,"version":2,"created":1554933732000,"modified":1554933734000,"deprecated":false,"name":"Keratin, type II cytoskeletal 71","accession":"Q3SY84","gene":"KRT71","description":"Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8830096942440253,"antibodyCount":64,"monoclonalCount":21,"pubmedCount":null,"jensenScore":7.823047,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.10492933434176,"pubTatorScore":1.044493584751832,"self":"https://pharos.nih.gov/idg/api/v1/targets(10854)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(10854)/properties"},"_links":{"count":663,"href":"https://pharos.nih.gov/idg/api/v1/targets(10854)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10854)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10854)/publications"},"_namespace":null},{"id":10855,"version":2,"created":1554933735000,"modified":1554933738000,"deprecated":false,"name":"Succinate dehydrogenase assembly factor 4, mitochondrial","accession":"Q5VUM1","gene":"SDHAF4","description":"Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.4408341494536652,"antibodyCount":33,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.275336,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.517945575427014,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10855)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":322,"href":"https://pharos.nih.gov/idg/api/v1/targets(10855)/properties"},"_links":{"count":995,"href":"https://pharos.nih.gov/idg/api/v1/targets(10855)/links"},"_synonyms":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(10855)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10855)/publications"},"_namespace":null},{"id":10856,"version":2,"created":1554933738000,"modified":1554933741000,"deprecated":false,"name":"NKAP-like protein","accession":"Q5M9Q1","gene":"NKAPL","description":"Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6379342444339311,"antibodyCount":67,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.769596,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.51671854563804,"pubTatorScore":0.5835765478692101,"self":"https://pharos.nih.gov/idg/api/v1/targets(10856)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":187,"href":"https://pharos.nih.gov/idg/api/v1/targets(10856)/properties"},"_links":{"count":725,"href":"https://pharos.nih.gov/idg/api/v1/targets(10856)/links"},"_synonyms":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10856)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10856)/publications"},"_namespace":null},{"id":10857,"version":2,"created":1554933742000,"modified":1554933744000,"deprecated":false,"name":"COBW domain-containing protein 5","accession":"Q5RIA9","gene":"CBWD5","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.282574184186778,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10857)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(10857)/properties"},"_links":{"count":971,"href":"https://pharos.nih.gov/idg/api/v1/targets(10857)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10857)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10857)/publications"},"_namespace":null},{"id":10858,"version":3,"created":1554933744000,"modified":1555039660000,"deprecated":false,"name":"Putative G antigen family E member 3","accession":"Q5JRK9","gene":"PAGE2B","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":14,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.380952,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":5.540998022443754,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10858)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10858)/properties"},"_links":{"count":544,"href":"https://pharos.nih.gov/idg/api/v1/targets(10858)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10858)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10858)/publications"},"_namespace":null},{"id":10859,"version":3,"created":1554933746000,"modified":1555039661000,"deprecated":false,"name":"Conserved oligomeric Golgi complex subunit 7","accession":"P83436","gene":"COG7","description":"Required for normal Golgi function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9696780643796207,"antibodyCount":162,"monoclonalCount":33,"pubmedCount":null,"jensenScore":8.652618,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":18,"knowledgeAvailability":32.94378660184492,"pubTatorScore":1.00757150740975,"self":"https://pharos.nih.gov/idg/api/v1/targets(10859)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(10859)/properties"},"_links":{"count":958,"href":"https://pharos.nih.gov/idg/api/v1/targets(10859)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10859)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10859)/publications"},"_namespace":null},{"id":10860,"version":3,"created":1554933750000,"modified":1555039662000,"deprecated":false,"name":"Tumor protein 63","accession":"Q9H3D4","gene":"TP63","description":"Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.0739818515855406,"antibodyCount":448,"monoclonalCount":118,"pubmedCount":null,"jensenScore":1154.054066,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":53.14689479210777,"pubTatorScore":3.253137758136102,"self":"https://pharos.nih.gov/idg/api/v1/targets(10860)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10860)/properties"},"_links":{"count":1955,"href":"https://pharos.nih.gov/idg/api/v1/targets(10860)/links"},"_synonyms":{"count":349,"href":"https://pharos.nih.gov/idg/api/v1/targets(10860)/synonyms"},"_publications":{"count":701,"href":"https://pharos.nih.gov/idg/api/v1/targets(10860)/publications"},"_namespace":null},{"id":10861,"version":2,"created":1554933764000,"modified":1554933768000,"deprecated":false,"name":"Integral membrane protein GPR155","accession":"Q7Z3F1","gene":"GPR155","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7078066621373845,"antibodyCount":83,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.230768,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.018131036895472,"pubTatorScore":-0.14612786196048003,"self":"https://pharos.nih.gov/idg/api/v1/targets(10861)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(10861)/properties"},"_links":{"count":907,"href":"https://pharos.nih.gov/idg/api/v1/targets(10861)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10861)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10861)/publications"},"_namespace":null},{"id":10862,"version":3,"created":1554933769000,"modified":1555039666000,"deprecated":false,"name":"NADP-dependent oxidoreductase domain-containing protein 1","accession":"Q6NXP6","gene":"NOXRED1","description":"Probable oxidoreductase.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":null,"antibodyCount":21,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":16.85212929642761,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10862)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(10862)/properties"},"_links":{"count":721,"href":"https://pharos.nih.gov/idg/api/v1/targets(10862)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10862)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10862)/publications"},"_namespace":null},{"id":10863,"version":2,"created":1554933772000,"modified":1554933774000,"deprecated":false,"name":"UDP-glucuronosyltransferase 3A2","accession":"Q3SY77","gene":"UGT3A2","description":"UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.13936845254187605,"antibodyCount":112,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.846903,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.38918912791378,"pubTatorScore":0.06694654146226692,"self":"https://pharos.nih.gov/idg/api/v1/targets(10863)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":166,"href":"https://pharos.nih.gov/idg/api/v1/targets(10863)/properties"},"_links":{"count":563,"href":"https://pharos.nih.gov/idg/api/v1/targets(10863)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10863)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10863)/publications"},"_namespace":null},{"id":10864,"version":3,"created":1554933774000,"modified":1555039667000,"deprecated":false,"name":"Protein FAM71F2","accession":"Q6NXP2","gene":"FAM71F2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.0,"antibodyCount":20,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":13.587623767913945,"pubTatorScore":0.0,"self":"https://pharos.nih.gov/idg/api/v1/targets(10864)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10864)/properties"},"_links":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(10864)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10864)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10864)/publications"},"_namespace":null},{"id":10865,"version":2,"created":1554933777000,"modified":1554933780000,"deprecated":false,"name":"KN motif and ankyrin repeat domain-containing protein 3","accession":"Q6NY19","gene":"KANK3","description":"May be involved in the control of cytoskeleton formation by regulating actin polymerization.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.024823583966306836,"antibodyCount":39,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.861602,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":27.066857134202213,"pubTatorScore":-0.057991946977686754,"self":"https://pharos.nih.gov/idg/api/v1/targets(10865)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10865)/properties"},"_links":{"count":886,"href":"https://pharos.nih.gov/idg/api/v1/targets(10865)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10865)/synonyms"},"_publications":{"count":8,"href":"https://pharos.nih.gov/idg/api/v1/targets(10865)/publications"},"_namespace":null},{"id":10866,"version":2,"created":1554933781000,"modified":1554933784000,"deprecated":false,"name":"Collagen alpha-1(XXIV) chain","accession":"Q17RW2","gene":"COL24A1","description":"May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5173601983067586,"antibodyCount":24,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.929762,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.253182184965247,"pubTatorScore":-0.954242943734024,"self":"https://pharos.nih.gov/idg/api/v1/targets(10866)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10866)/properties"},"_links":{"count":873,"href":"https://pharos.nih.gov/idg/api/v1/targets(10866)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10866)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10866)/publications"},"_namespace":null},{"id":10867,"version":2,"created":1554933785000,"modified":1554933787000,"deprecated":false,"name":"EF-hand calcium-binding domain-containing protein 12","accession":"Q6NXP0","gene":"EFCAB12","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":27,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":19.258198211660698,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10867)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":179,"href":"https://pharos.nih.gov/idg/api/v1/targets(10867)/properties"},"_links":{"count":739,"href":"https://pharos.nih.gov/idg/api/v1/targets(10867)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10867)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10867)/publications"},"_namespace":null},{"id":10868,"version":2,"created":1554933787000,"modified":1554933789000,"deprecated":false,"name":"Gametogenetin-binding protein 2","accession":"Q9H3C7","gene":"GGNBP2","description":"May be involved in spermatogenesis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4213629672392731,"antibodyCount":81,"monoclonalCount":0,"pubmedCount":null,"jensenScore":30.261022,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.49471272336069,"pubTatorScore":1.3351321078086424,"self":"https://pharos.nih.gov/idg/api/v1/targets(10868)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":295,"href":"https://pharos.nih.gov/idg/api/v1/targets(10868)/properties"},"_links":{"count":370,"href":"https://pharos.nih.gov/idg/api/v1/targets(10868)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10868)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10868)/publications"},"_namespace":null},{"id":10869,"version":2,"created":1554933790000,"modified":1554933793000,"deprecated":false,"name":"Immunoglobulin superfamily member 10","accession":"Q6WRI0","gene":"IGSF10","description":"Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.2414312979753023,"antibodyCount":45,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.778091,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.95490750962117,"pubTatorScore":-0.03778840296416235,"self":"https://pharos.nih.gov/idg/api/v1/targets(10869)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":235,"href":"https://pharos.nih.gov/idg/api/v1/targets(10869)/properties"},"_links":{"count":858,"href":"https://pharos.nih.gov/idg/api/v1/targets(10869)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10869)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10869)/publications"},"_namespace":null},{"id":10870,"version":2,"created":1554933794000,"modified":1554933796000,"deprecated":false,"name":"Clarin-1","accession":"P58418","gene":"CLRN1","description":"May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4245547732700843,"antibodyCount":29,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.74395,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.070828935919778,"pubTatorScore":1.693409367084907,"self":"https://pharos.nih.gov/idg/api/v1/targets(10870)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":193,"href":"https://pharos.nih.gov/idg/api/v1/targets(10870)/properties"},"_links":{"count":334,"href":"https://pharos.nih.gov/idg/api/v1/targets(10870)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10870)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10870)/publications"},"_namespace":null},{"id":10871,"version":4,"created":1554933796000,"modified":1555039669000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 5","accession":"P22460","gene":"KCNA5","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.615275720907091,"antibodyCount":209,"monoclonalCount":27,"pubmedCount":null,"jensenScore":428.335299,"patentCount":42372,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":26,"knowledgeAvailability":39.11571787338305,"pubTatorScore":2.536126291471813,"self":"https://pharos.nih.gov/idg/api/v1/targets(10871)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(10871)/properties"},"_links":{"count":1513,"href":"https://pharos.nih.gov/idg/api/v1/targets(10871)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10871)/synonyms"},"_publications":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10871)/publications"},"_namespace":null},{"id":10872,"version":2,"created":1554933974000,"modified":1554933976000,"deprecated":false,"name":"Neurexophilin-1","accession":"P58417","gene":"NXPH1","description":"May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0024232056752718,"antibodyCount":168,"monoclonalCount":5,"pubmedCount":null,"jensenScore":11.376581,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.420982586133444,"pubTatorScore":1.367674535267301,"self":"https://pharos.nih.gov/idg/api/v1/targets(10872)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(10872)/properties"},"_links":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(10872)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10872)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10872)/publications"},"_namespace":null},{"id":10873,"version":2,"created":1554933977000,"modified":1554933980000,"deprecated":false,"name":"Poly(U)-specific endoribonuclease","accession":"P21128","gene":"ENDOU","description":"Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5361767126631716,"antibodyCount":40,"monoclonalCount":10,"pubmedCount":null,"jensenScore":34.617408,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.689676947569072,"pubTatorScore":2.6605887376279225,"self":"https://pharos.nih.gov/idg/api/v1/targets(10873)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10873)/properties"},"_links":{"count":771,"href":"https://pharos.nih.gov/idg/api/v1/targets(10873)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10873)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10873)/publications"},"_namespace":null},{"id":10874,"version":2,"created":1554933981000,"modified":1554933989000,"deprecated":false,"name":"Potassium voltage-gated channel subfamily A member 4","accession":"P22459","gene":"KCNA4","description":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).","idgFamily":"Ion Channel","idgTDL":"Tclin","novelty":-2.328034298576159,"antibodyCount":155,"monoclonalCount":27,"pubmedCount":null,"jensenScore":199.779081,"patentCount":10492,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.13838720217622,"pubTatorScore":2.034840984345414,"self":"https://pharos.nih.gov/idg/api/v1/targets(10874)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":250,"href":"https://pharos.nih.gov/idg/api/v1/targets(10874)/properties"},"_links":{"count":743,"href":"https://pharos.nih.gov/idg/api/v1/targets(10874)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10874)/synonyms"},"_publications":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(10874)/publications"},"_namespace":null},{"id":10875,"version":3,"created":1554933990000,"modified":1555039671000,"deprecated":false,"name":"Tropomyosin alpha-1 chain","accession":"P09493","gene":"TPM1","description":"Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.195372005613051,"antibodyCount":227,"monoclonalCount":58,"pubmedCount":null,"jensenScore":154.343489,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":17,"knowledgeAvailability":52.745969217966405,"pubTatorScore":1.63869877595785,"self":"https://pharos.nih.gov/idg/api/v1/targets(10875)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":572,"href":"https://pharos.nih.gov/idg/api/v1/targets(10875)/properties"},"_links":{"count":1430,"href":"https://pharos.nih.gov/idg/api/v1/targets(10875)/links"},"_synonyms":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(10875)/synonyms"},"_publications":{"count":160,"href":"https://pharos.nih.gov/idg/api/v1/targets(10875)/publications"},"_namespace":null},{"id":10876,"version":2,"created":1554934000000,"modified":1554934008000,"deprecated":false,"name":"Carnitine O-palmitoyltransferase 2, mitochondrial","accession":"P23786","gene":"CPT2","description":null,"idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.285151576567819,"antibodyCount":359,"monoclonalCount":22,"pubmedCount":null,"jensenScore":186.948949,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.07680296705277,"pubTatorScore":2.548199594265675,"self":"https://pharos.nih.gov/idg/api/v1/targets(10876)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":454,"href":"https://pharos.nih.gov/idg/api/v1/targets(10876)/properties"},"_links":{"count":1238,"href":"https://pharos.nih.gov/idg/api/v1/targets(10876)/links"},"_synonyms":{"count":101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10876)/synonyms"},"_publications":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10876)/publications"},"_namespace":null},{"id":10877,"version":2,"created":1554934009000,"modified":1554934014000,"deprecated":false,"name":"Clathrin light chain A","accession":"P09496","gene":"CLTA","description":"Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3267636587967293,"antibodyCount":244,"monoclonalCount":88,"pubmedCount":null,"jensenScore":15.997188,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.8936796967754,"pubTatorScore":1.4810385180139745,"self":"https://pharos.nih.gov/idg/api/v1/targets(10877)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":446,"href":"https://pharos.nih.gov/idg/api/v1/targets(10877)/properties"},"_links":{"count":1314,"href":"https://pharos.nih.gov/idg/api/v1/targets(10877)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10877)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(10877)/publications"},"_namespace":null},{"id":10878,"version":2,"created":1554934015000,"modified":1554934019000,"deprecated":false,"name":"Clathrin light chain B","accession":"P09497","gene":"CLTB","description":"Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2910516377724615,"antibodyCount":153,"monoclonalCount":25,"pubmedCount":null,"jensenScore":193.560732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.15246382925273,"pubTatorScore":1.8255834609634671,"self":"https://pharos.nih.gov/idg/api/v1/targets(10878)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":423,"href":"https://pharos.nih.gov/idg/api/v1/targets(10878)/properties"},"_links":{"count":1150,"href":"https://pharos.nih.gov/idg/api/v1/targets(10878)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10878)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10878)/publications"},"_namespace":null},{"id":10879,"version":2,"created":1554934020000,"modified":1554934022000,"deprecated":false,"name":"Cyclin-dependent kinase 11B","accession":"P21127","gene":"CDK11B","description":"Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.1549260950211386,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":16.563087,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.9329801714157,"pubTatorScore":2.008840644707488,"self":"https://pharos.nih.gov/idg/api/v1/targets(10879)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":260,"href":"https://pharos.nih.gov/idg/api/v1/targets(10879)/properties"},"_links":{"count":212,"href":"https://pharos.nih.gov/idg/api/v1/targets(10879)/links"},"_synonyms":{"count":152,"href":"https://pharos.nih.gov/idg/api/v1/targets(10879)/synonyms"},"_publications":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10879)/publications"},"_namespace":null},{"id":10880,"version":3,"created":1554934023000,"modified":1555039674000,"deprecated":false,"name":"F-actin-capping protein subunit alpha-2","accession":"P47755","gene":"CAPZA2","description":"F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.5657370619945536,"antibodyCount":128,"monoclonalCount":8,"pubmedCount":null,"jensenScore":3.272755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":41,"knowledgeAvailability":39.57873094524601,"pubTatorScore":1.4142236602242089,"self":"https://pharos.nih.gov/idg/api/v1/targets(10880)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":335,"href":"https://pharos.nih.gov/idg/api/v1/targets(10880)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(10880)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10880)/synonyms"},"_publications":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10880)/publications"},"_namespace":null},{"id":10881,"version":3,"created":1554934027000,"modified":1555039675000,"deprecated":false,"name":"F-actin-capping protein subunit beta","accession":"P47756","gene":"CAPZB","description":"F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.282142008783524,"antibodyCount":226,"monoclonalCount":44,"pubmedCount":null,"jensenScore":20.206904,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":47.9054909308992,"pubTatorScore":1.3875804468961528,"self":"https://pharos.nih.gov/idg/api/v1/targets(10881)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(10881)/properties"},"_links":{"count":1177,"href":"https://pharos.nih.gov/idg/api/v1/targets(10881)/links"},"_synonyms":{"count":105,"href":"https://pharos.nih.gov/idg/api/v1/targets(10881)/synonyms"},"_publications":{"count":43,"href":"https://pharos.nih.gov/idg/api/v1/targets(10881)/publications"},"_namespace":null},{"id":10882,"version":2,"created":1554934032000,"modified":1554934040000,"deprecated":false,"name":"Fibroblast growth factor receptor 4","accession":"P22455","gene":"FGFR4","description":"Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.","idgFamily":"Kinase","idgTDL":"Tclin","novelty":-2.4425529538506408,"antibodyCount":502,"monoclonalCount":192,"pubmedCount":null,"jensenScore":276.432167,"patentCount":139693,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.28636859569958,"pubTatorScore":2.425085215876858,"self":"https://pharos.nih.gov/idg/api/v1/targets(10882)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":638,"href":"https://pharos.nih.gov/idg/api/v1/targets(10882)/properties"},"_links":{"count":1207,"href":"https://pharos.nih.gov/idg/api/v1/targets(10882)/links"},"_synonyms":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10882)/synonyms"},"_publications":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10882)/publications"},"_namespace":null},{"id":10883,"version":2,"created":1554934041000,"modified":1554934044000,"deprecated":false,"name":"Protein ABHD16B","accession":"Q9H3Z7","gene":"ABHD16B","description":null,"idgFamily":"Enzyme","idgTDL":"Tdark","novelty":1.0,"antibodyCount":6,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.1,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":14.503165458989585,"pubTatorScore":-1.041393119452924,"self":"https://pharos.nih.gov/idg/api/v1/targets(10883)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(10883)/properties"},"_links":{"count":753,"href":"https://pharos.nih.gov/idg/api/v1/targets(10883)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10883)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10883)/publications"},"_namespace":null},{"id":10884,"version":3,"created":1554934045000,"modified":1555039679000,"deprecated":false,"name":"Protein GREB1","accession":"Q4ZG55","gene":"GREB1","description":"May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.518988009464336,"antibodyCount":141,"monoclonalCount":13,"pubmedCount":null,"jensenScore":31.168104,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.77006306659526,"pubTatorScore":1.4370166669623758,"self":"https://pharos.nih.gov/idg/api/v1/targets(10884)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":283,"href":"https://pharos.nih.gov/idg/api/v1/targets(10884)/properties"},"_links":{"count":900,"href":"https://pharos.nih.gov/idg/api/v1/targets(10884)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10884)/synonyms"},"_publications":{"count":30,"href":"https://pharos.nih.gov/idg/api/v1/targets(10884)/publications"},"_namespace":null},{"id":10885,"version":2,"created":1554934049000,"modified":1554934053000,"deprecated":false,"name":"DnaJ homolog subfamily C member 5","accession":"Q9H3Z4","gene":"DNAJC5","description":"Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9850814703813515,"antibodyCount":193,"monoclonalCount":4,"pubmedCount":null,"jensenScore":92.505985,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.87311488677514,"pubTatorScore":2.1501225674410582,"self":"https://pharos.nih.gov/idg/api/v1/targets(10885)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":432,"href":"https://pharos.nih.gov/idg/api/v1/targets(10885)/properties"},"_links":{"count":1097,"href":"https://pharos.nih.gov/idg/api/v1/targets(10885)/links"},"_synonyms":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10885)/synonyms"},"_publications":{"count":56,"href":"https://pharos.nih.gov/idg/api/v1/targets(10885)/publications"},"_namespace":null},{"id":10886,"version":3,"created":1554934054000,"modified":1555039680000,"deprecated":false,"name":"Complement decay-accelerating factor","accession":"P08174","gene":"CD55","description":"(Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0552262507064705,"antibodyCount":1004,"monoclonalCount":700,"pubmedCount":null,"jensenScore":1115.162486,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":48.34440071598385,"pubTatorScore":2.8851665593286158,"self":"https://pharos.nih.gov/idg/api/v1/targets(10886)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":631,"href":"https://pharos.nih.gov/idg/api/v1/targets(10886)/properties"},"_links":{"count":1308,"href":"https://pharos.nih.gov/idg/api/v1/targets(10886)/links"},"_synonyms":{"count":215,"href":"https://pharos.nih.gov/idg/api/v1/targets(10886)/synonyms"},"_publications":{"count":208,"href":"https://pharos.nih.gov/idg/api/v1/targets(10886)/publications"},"_namespace":null},{"id":10887,"version":2,"created":1554934061000,"modified":1554934064000,"deprecated":false,"name":"Transmembrane protein 131-like","accession":"A2VDJ0","gene":"TMEM131L","description":"Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.13830269653767713,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.829808,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.25527250510330607,"self":"https://pharos.nih.gov/idg/api/v1/targets(10887)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10887)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(10887)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10887)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10887)/publications"},"_namespace":null},{"id":10888,"version":4,"created":1554934065000,"modified":1555039683000,"deprecated":false,"name":"Muscarinic acetylcholine receptor M2","accession":"P08172","gene":"CHRM2","description":"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.7001703142968276,"antibodyCount":391,"monoclonalCount":81,"pubmedCount":null,"jensenScore":498.158169,"patentCount":6250,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.99029875748773,"pubTatorScore":2.4559636080495593,"self":"https://pharos.nih.gov/idg/api/v1/targets(10888)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":567,"href":"https://pharos.nih.gov/idg/api/v1/targets(10888)/properties"},"_links":{"count":1714,"href":"https://pharos.nih.gov/idg/api/v1/targets(10888)/links"},"_synonyms":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(10888)/synonyms"},"_publications":{"count":136,"href":"https://pharos.nih.gov/idg/api/v1/targets(10888)/publications"},"_namespace":null},{"id":10889,"version":4,"created":1554934205000,"modified":1555039687000,"deprecated":false,"name":"Muscarinic acetylcholine receptor M4","accession":"P08173","gene":"CHRM4","description":"The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-1.9099508537905634,"antibodyCount":130,"monoclonalCount":22,"pubmedCount":null,"jensenScore":79.802667,"patentCount":3051,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":55,"knowledgeAvailability":33.37462470627542,"pubTatorScore":1.6409823357583253,"self":"https://pharos.nih.gov/idg/api/v1/targets(10889)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(10889)/properties"},"_links":{"count":1033,"href":"https://pharos.nih.gov/idg/api/v1/targets(10889)/links"},"_synonyms":{"count":143,"href":"https://pharos.nih.gov/idg/api/v1/targets(10889)/synonyms"},"_publications":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10889)/publications"},"_namespace":null},{"id":10890,"version":3,"created":1554934226000,"modified":1555039689000,"deprecated":false,"name":"Galanin peptides","accession":"P22466","gene":"GAL","description":"Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.3231966877310346,"antibodyCount":242,"monoclonalCount":40,"pubmedCount":null,"jensenScore":2240.205411,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":35.94099247735218,"pubTatorScore":2.360803662289512,"self":"https://pharos.nih.gov/idg/api/v1/targets(10890)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":384,"href":"https://pharos.nih.gov/idg/api/v1/targets(10890)/properties"},"_links":{"count":919,"href":"https://pharos.nih.gov/idg/api/v1/targets(10890)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10890)/synonyms"},"_publications":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10890)/publications"},"_namespace":null},{"id":10891,"version":2,"created":1554934232000,"modified":1554934234000,"deprecated":false,"name":"Tumor necrosis factor alpha-induced protein 8-like protein 3","accession":"Q5GJ75","gene":"TNFAIP8L3","description":"Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.6430037855224574,"antibodyCount":66,"monoclonalCount":0,"pubmedCount":null,"jensenScore":4.228583,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":17.1043325266813,"pubTatorScore":0.5576408381766422,"self":"https://pharos.nih.gov/idg/api/v1/targets(10891)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(10891)/properties"},"_links":{"count":916,"href":"https://pharos.nih.gov/idg/api/v1/targets(10891)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10891)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10891)/publications"},"_namespace":null},{"id":10892,"version":3,"created":1554934234000,"modified":1555039690000,"deprecated":false,"name":"Sodium/calcium exchanger 3","accession":"P57103","gene":"SLC8A3","description":"Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity).","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-1.8717018845589333,"antibodyCount":128,"monoclonalCount":4,"pubmedCount":null,"jensenScore":72.342458,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":37.13585753137986,"pubTatorScore":1.5838462176716344,"self":"https://pharos.nih.gov/idg/api/v1/targets(10892)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(10892)/properties"},"_links":{"count":912,"href":"https://pharos.nih.gov/idg/api/v1/targets(10892)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10892)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10892)/publications"},"_namespace":null},{"id":10893,"version":3,"created":1554934239000,"modified":1555039693000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2","accession":"P59768","gene":"GNG2","description":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9742436445368835,"antibodyCount":75,"monoclonalCount":21,"pubmedCount":null,"jensenScore":10.003772,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":28,"knowledgeAvailability":35.4984126368907,"pubTatorScore":0.8687232977022303,"self":"https://pharos.nih.gov/idg/api/v1/targets(10893)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":437,"href":"https://pharos.nih.gov/idg/api/v1/targets(10893)/properties"},"_links":{"count":1026,"href":"https://pharos.nih.gov/idg/api/v1/targets(10893)/links"},"_synonyms":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(10893)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10893)/publications"},"_namespace":null},{"id":10894,"version":3,"created":1554934244000,"modified":1555039695000,"deprecated":false,"name":"Synaptojanin-2-binding protein","accession":"P57105","gene":"SYNJ2BP","description":"Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.602286057003737,"antibodyCount":54,"monoclonalCount":11,"pubmedCount":null,"jensenScore":41.776978,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":15,"knowledgeAvailability":36.573598807837314,"pubTatorScore":1.2319172894940533,"self":"https://pharos.nih.gov/idg/api/v1/targets(10894)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":312,"href":"https://pharos.nih.gov/idg/api/v1/targets(10894)/properties"},"_links":{"count":936,"href":"https://pharos.nih.gov/idg/api/v1/targets(10894)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10894)/synonyms"},"_publications":{"count":19,"href":"https://pharos.nih.gov/idg/api/v1/targets(10894)/publications"},"_namespace":null},{"id":10895,"version":2,"created":1554934248000,"modified":1554934253000,"deprecated":false,"name":"Tyrosine-protein kinase Srms","accession":"Q9H3Y6","gene":"SRMS","description":"Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.3507083781373435,"antibodyCount":142,"monoclonalCount":2,"pubmedCount":null,"jensenScore":23.048714,"patentCount":2591,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.36491274786934,"pubTatorScore":0.45229761990115885,"self":"https://pharos.nih.gov/idg/api/v1/targets(10895)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":222,"href":"https://pharos.nih.gov/idg/api/v1/targets(10895)/properties"},"_links":{"count":821,"href":"https://pharos.nih.gov/idg/api/v1/targets(10895)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10895)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10895)/publications"},"_namespace":null},{"id":10896,"version":3,"created":1554934254000,"modified":1555039696000,"deprecated":false,"name":"Osteopontin","accession":"P10451","gene":"SPP1","description":"Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.6638405735152193,"antibodyCount":1053,"monoclonalCount":366,"pubmedCount":null,"jensenScore":4916.506274,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":46.02425265309401,"pubTatorScore":3.495264934453455,"self":"https://pharos.nih.gov/idg/api/v1/targets(10896)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":1305,"href":"https://pharos.nih.gov/idg/api/v1/targets(10896)/properties"},"_links":{"count":1999,"href":"https://pharos.nih.gov/idg/api/v1/targets(10896)/links"},"_synonyms":{"count":141,"href":"https://pharos.nih.gov/idg/api/v1/targets(10896)/synonyms"},"_publications":{"count":881,"href":"https://pharos.nih.gov/idg/api/v1/targets(10896)/publications"},"_namespace":null},{"id":10897,"version":2,"created":1554934266000,"modified":1554934269000,"deprecated":false,"name":"Pancreatic progenitor cell differentiation and proliferation factor","accession":"Q9H3Y8","gene":"PPDPF","description":"Probable regulator of exocrine pancreas development.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.361986421036688,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.880953,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.65518484279611,"pubTatorScore":0.17367188198130376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10897)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10897)/properties"},"_links":{"count":870,"href":"https://pharos.nih.gov/idg/api/v1/targets(10897)/links"},"_synonyms":{"count":59,"href":"https://pharos.nih.gov/idg/api/v1/targets(10897)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10897)/publications"},"_namespace":null},{"id":10898,"version":3,"created":1554934270000,"modified":1555039701000,"deprecated":false,"name":"Glutaredoxin-1","accession":"P35754","gene":"GLRX","description":"Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.656422054523603,"antibodyCount":163,"monoclonalCount":44,"pubmedCount":null,"jensenScore":453.45184,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":45.990312105741836,"pubTatorScore":2.4502395321744648,"self":"https://pharos.nih.gov/idg/api/v1/targets(10898)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(10898)/properties"},"_links":{"count":1192,"href":"https://pharos.nih.gov/idg/api/v1/targets(10898)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(10898)/synonyms"},"_publications":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10898)/publications"},"_namespace":null},{"id":10899,"version":2,"created":1554934276000,"modified":1554934277000,"deprecated":false,"name":"Ribose-phosphate pyrophosphokinase 3","accession":"P21108","gene":"PRPS1L1","description":"Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.","idgFamily":"Kinase","idgTDL":"Tdark","novelty":-1.2637401825398424,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":18.276838,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.690415742326504,"pubTatorScore":0.4687691592726397,"self":"https://pharos.nih.gov/idg/api/v1/targets(10899)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":177,"href":"https://pharos.nih.gov/idg/api/v1/targets(10899)/properties"},"_links":{"count":194,"href":"https://pharos.nih.gov/idg/api/v1/targets(10899)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10899)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10899)/publications"},"_namespace":null},{"id":10900,"version":3,"created":1554934277000,"modified":1555039703000,"deprecated":false,"name":"Endothelial transcription factor GATA-2","accession":"P23769","gene":"GATA2","description":"Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.7035498167861514,"antibodyCount":354,"monoclonalCount":72,"pubmedCount":null,"jensenScore":475.513125,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":48.03152928918092,"pubTatorScore":2.4634094142781167,"self":"https://pharos.nih.gov/idg/api/v1/targets(10900)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":651,"href":"https://pharos.nih.gov/idg/api/v1/targets(10900)/properties"},"_links":{"count":1186,"href":"https://pharos.nih.gov/idg/api/v1/targets(10900)/links"},"_synonyms":{"count":129,"href":"https://pharos.nih.gov/idg/api/v1/targets(10900)/synonyms"},"_publications":{"count":186,"href":"https://pharos.nih.gov/idg/api/v1/targets(10900)/publications"},"_namespace":null},{"id":10901,"version":2,"created":1554934284000,"modified":1554934284000,"deprecated":false,"name":"UPF0258 protein KIAA1024-like","accession":"P59773","gene":"KIAA1024L","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":4,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.513737753944971,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10901)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":164,"href":"https://pharos.nih.gov/idg/api/v1/targets(10901)/properties"},"_links":{"count":386,"href":"https://pharos.nih.gov/idg/api/v1/targets(10901)/links"},"_synonyms":{"count":44,"href":"https://pharos.nih.gov/idg/api/v1/targets(10901)/synonyms"},"_publications":{"count":1,"href":"https://pharos.nih.gov/idg/api/v1/targets(10901)/publications"},"_namespace":null},{"id":10902,"version":2,"created":1554934285000,"modified":1554934286000,"deprecated":false,"name":"Peptidase inhibitor R3HDML","accession":"Q9H3Y0","gene":"R3HDML","description":"Putative serine protease inhibitor.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":0.10145763913017275,"antibodyCount":16,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.713929,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.079977411676907,"pubTatorScore":-0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10902)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":150,"href":"https://pharos.nih.gov/idg/api/v1/targets(10902)/properties"},"_links":{"count":227,"href":"https://pharos.nih.gov/idg/api/v1/targets(10902)/links"},"_synonyms":{"count":60,"href":"https://pharos.nih.gov/idg/api/v1/targets(10902)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10902)/publications"},"_namespace":null},{"id":10903,"version":2,"created":1554934286000,"modified":1554934290000,"deprecated":false,"name":"Guanine nucleotide-binding protein G(o) subunit alpha","accession":"P09471","gene":"GNAO1","description":"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.2433129354962076,"antibodyCount":195,"monoclonalCount":11,"pubmedCount":null,"jensenScore":158.746133,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.06673594894442,"pubTatorScore":1.9639338815091,"self":"https://pharos.nih.gov/idg/api/v1/targets(10903)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(10903)/properties"},"_links":{"count":1023,"href":"https://pharos.nih.gov/idg/api/v1/targets(10903)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10903)/synonyms"},"_publications":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10903)/publications"},"_namespace":null},{"id":10904,"version":3,"created":1554934291000,"modified":1555039705000,"deprecated":false,"name":"Uncharacterized protein C1orf146","accession":"Q5VVC0","gene":"C1orf146","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":38,"monoclonalCount":1,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10904)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(10904)/properties"},"_links":{"count":543,"href":"https://pharos.nih.gov/idg/api/v1/targets(10904)/links"},"_synonyms":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10904)/synonyms"},"_publications":{"count":4,"href":"https://pharos.nih.gov/idg/api/v1/targets(10904)/publications"},"_namespace":null},{"id":10905,"version":3,"created":1554934293000,"modified":1555039706000,"deprecated":false,"name":"Paired box protein Pax-3","accession":"P23760","gene":"PAX3","description":"Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-2.838706882579747,"antibodyCount":400,"monoclonalCount":112,"pubmedCount":null,"jensenScore":692.051694,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":42.58488698091982,"pubTatorScore":2.617854918289319,"self":"https://pharos.nih.gov/idg/api/v1/targets(10905)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":546,"href":"https://pharos.nih.gov/idg/api/v1/targets(10905)/properties"},"_links":{"count":1064,"href":"https://pharos.nih.gov/idg/api/v1/targets(10905)/links"},"_synonyms":{"count":189,"href":"https://pharos.nih.gov/idg/api/v1/targets(10905)/synonyms"},"_publications":{"count":196,"href":"https://pharos.nih.gov/idg/api/v1/targets(10905)/publications"},"_namespace":null},{"id":10906,"version":2,"created":1554934300000,"modified":1554934305000,"deprecated":false,"name":"Rap1 GTPase-activating protein 1","accession":"P47736","gene":"RAP1GAP","description":"GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.8655544908312136,"antibodyCount":168,"monoclonalCount":38,"pubmedCount":null,"jensenScore":64.94755,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.35456328873569,"pubTatorScore":1.7615256744095626,"self":"https://pharos.nih.gov/idg/api/v1/targets(10906)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":369,"href":"https://pharos.nih.gov/idg/api/v1/targets(10906)/properties"},"_links":{"count":997,"href":"https://pharos.nih.gov/idg/api/v1/targets(10906)/links"},"_synonyms":{"count":127,"href":"https://pharos.nih.gov/idg/api/v1/targets(10906)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10906)/publications"},"_namespace":null},{"id":10907,"version":3,"created":1554934306000,"modified":1555039708000,"deprecated":false,"name":"Centrosome and spindle pole-associated protein 1","accession":"Q1MSJ5","gene":"CSPP1","description":"May play a role in cell-cycle-dependent microtubule organization.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.4041076926904144,"antibodyCount":110,"monoclonalCount":0,"pubmedCount":null,"jensenScore":26.306474,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":14,"knowledgeAvailability":37.85741608964006,"pubTatorScore":1.2592752316195674,"self":"https://pharos.nih.gov/idg/api/v1/targets(10907)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":273,"href":"https://pharos.nih.gov/idg/api/v1/targets(10907)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(10907)/links"},"_synonyms":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10907)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10907)/publications"},"_namespace":null},{"id":10908,"version":2,"created":1554934310000,"modified":1554934315000,"deprecated":false,"name":"Heterogeneous nuclear ribonucleoprotein U-like protein 2","accession":"Q1KMD3","gene":"HNRNPUL2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4771212590626073,"antibodyCount":40,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.333333,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.87792818336804,"pubTatorScore":0.3010299956639812,"self":"https://pharos.nih.gov/idg/api/v1/targets(10908)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":344,"href":"https://pharos.nih.gov/idg/api/v1/targets(10908)/properties"},"_links":{"count":1054,"href":"https://pharos.nih.gov/idg/api/v1/targets(10908)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10908)/synonyms"},"_publications":{"count":12,"href":"https://pharos.nih.gov/idg/api/v1/targets(10908)/publications"},"_namespace":null},{"id":10909,"version":2,"created":1554934315000,"modified":1554934322000,"deprecated":false,"name":"Vesicle-associated membrane protein 1","accession":"P23763","gene":"VAMP1","description":"Involved in the targeting and/or fusion of transport vesicles to their target membrane.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.7585299759070996,"antibodyCount":249,"monoclonalCount":152,"pubmedCount":null,"jensenScore":52.602165,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.75646331726116,"pubTatorScore":1.4563570130730563,"self":"https://pharos.nih.gov/idg/api/v1/targets(10909)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(10909)/properties"},"_links":{"count":1188,"href":"https://pharos.nih.gov/idg/api/v1/targets(10909)/links"},"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(10909)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10909)/publications"},"_namespace":null},{"id":10910,"version":2,"created":1554934323000,"modified":1554934329000,"deprecated":false,"name":"Myosin-11","accession":"P35749","gene":"MYH11","description":"Muscle contraction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.634528863066658,"antibodyCount":263,"monoclonalCount":173,"pubmedCount":null,"jensenScore":415.309848,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.84399229668489,"pubTatorScore":2.28094717284117,"self":"https://pharos.nih.gov/idg/api/v1/targets(10910)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":405,"href":"https://pharos.nih.gov/idg/api/v1/targets(10910)/properties"},"_links":{"count":1235,"href":"https://pharos.nih.gov/idg/api/v1/targets(10910)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(10910)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(10910)/publications"},"_namespace":null},{"id":10911,"version":2,"created":1554934330000,"modified":1554934334000,"deprecated":false,"name":"Coiled-coil domain-containing protein 80","accession":"Q76M96","gene":"CCDC80","description":"Promotes cell adhesion and matrix assembly.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8302456490056669,"antibodyCount":65,"monoclonalCount":0,"pubmedCount":null,"jensenScore":70.844297,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":29.85384829423052,"pubTatorScore":1.230723002426249,"self":"https://pharos.nih.gov/idg/api/v1/targets(10911)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(10911)/properties"},"_links":{"count":890,"href":"https://pharos.nih.gov/idg/api/v1/targets(10911)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10911)/synonyms"},"_publications":{"count":21,"href":"https://pharos.nih.gov/idg/api/v1/targets(10911)/publications"},"_namespace":null},{"id":10912,"version":2,"created":1554934335000,"modified":1554934340000,"deprecated":false,"name":"A disintegrin and metalloproteinase with thrombospondin motifs 13","accession":"Q76LX8","gene":"ADAMTS13","description":"Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.1608677660503446,"antibodyCount":272,"monoclonalCount":67,"pubmedCount":null,"jensenScore":1422.048723,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":35.2218060175394,"pubTatorScore":3.1049568638353793,"self":"https://pharos.nih.gov/idg/api/v1/targets(10912)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":684,"href":"https://pharos.nih.gov/idg/api/v1/targets(10912)/properties"},"_links":{"count":1249,"href":"https://pharos.nih.gov/idg/api/v1/targets(10912)/links"},"_synonyms":{"count":148,"href":"https://pharos.nih.gov/idg/api/v1/targets(10912)/synonyms"},"_publications":{"count":400,"href":"https://pharos.nih.gov/idg/api/v1/targets(10912)/publications"},"_namespace":null},{"id":10913,"version":3,"created":1554934342000,"modified":1555039711000,"deprecated":false,"name":"Histone H2A.Z","accession":"P0C0S5","gene":"H2AFZ","description":"Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.5331205219379567,"antibodyCount":285,"monoclonalCount":28,"pubmedCount":null,"jensenScore":344.779661,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":44,"knowledgeAvailability":42.019141563957994,"pubTatorScore":2.2600051792786107,"self":"https://pharos.nih.gov/idg/api/v1/targets(10913)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":521,"href":"https://pharos.nih.gov/idg/api/v1/targets(10913)/properties"},"_links":{"count":1218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10913)/links"},"_synonyms":{"count":158,"href":"https://pharos.nih.gov/idg/api/v1/targets(10913)/synonyms"},"_publications":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10913)/publications"},"_namespace":null},{"id":10914,"version":2,"created":1554934347000,"modified":1554934348000,"deprecated":false,"name":"Torsin-1A-interacting protein 2, isoform IFRG15","accession":"Q9H496","gene":"TOR1AIP2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":41,"monoclonalCount":2,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":0.9048957698346877,"self":"https://pharos.nih.gov/idg/api/v1/targets(10914)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":99,"href":"https://pharos.nih.gov/idg/api/v1/targets(10914)/properties"},"_links":{"count":126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10914)/links"},"_synonyms":{"count":69,"href":"https://pharos.nih.gov/idg/api/v1/targets(10914)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10914)/publications"},"_namespace":null},{"id":10915,"version":3,"created":1554934349000,"modified":1555039713000,"deprecated":false,"name":"Torsin-3A","accession":"Q9H497","gene":"TOR3A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.115289578089019,"antibodyCount":101,"monoclonalCount":2,"pubmedCount":null,"jensenScore":122.569085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":37.32067720468063,"pubTatorScore":1.5797835966168101,"self":"https://pharos.nih.gov/idg/api/v1/targets(10915)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":323,"href":"https://pharos.nih.gov/idg/api/v1/targets(10915)/properties"},"_links":{"count":1014,"href":"https://pharos.nih.gov/idg/api/v1/targets(10915)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10915)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10915)/publications"},"_namespace":null},{"id":10916,"version":3,"created":1554934354000,"modified":1555039714000,"deprecated":false,"name":"Microtubule-associated proteins 1A/1B light chain 3A","accession":"Q9H492","gene":"MAP1LC3A","description":"Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.184139454703144,"antibodyCount":944,"monoclonalCount":148,"pubmedCount":null,"jensenScore":134.071149,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":28.244310989888827,"pubTatorScore":2.7597429009064816,"self":"https://pharos.nih.gov/idg/api/v1/targets(10916)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":455,"href":"https://pharos.nih.gov/idg/api/v1/targets(10916)/properties"},"_links":{"count":1126,"href":"https://pharos.nih.gov/idg/api/v1/targets(10916)/links"},"_synonyms":{"count":120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10916)/synonyms"},"_publications":{"count":168,"href":"https://pharos.nih.gov/idg/api/v1/targets(10916)/publications"},"_namespace":null},{"id":10917,"version":2,"created":1554934360000,"modified":1554934362000,"deprecated":false,"name":"AP-3 complex subunit sigma-2","accession":"P59780","gene":"AP3S2","description":"Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.27929749002250787,"antibodyCount":66,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.6629,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.70130750297468,"pubTatorScore":0.23528800341427245,"self":"https://pharos.nih.gov/idg/api/v1/targets(10917)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":241,"href":"https://pharos.nih.gov/idg/api/v1/targets(10917)/properties"},"_links":{"count":844,"href":"https://pharos.nih.gov/idg/api/v1/targets(10917)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10917)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10917)/publications"},"_namespace":null},{"id":10918,"version":2,"created":1554934363000,"modified":1554934370000,"deprecated":false,"name":"Histone H2A type 1","accession":"P0C0S8","gene":"HIST1H2AG","description":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.0930875042988424,"antibodyCount":157,"monoclonalCount":7,"pubmedCount":null,"jensenScore":9.427884,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.89900897509286,"pubTatorScore":0.535715927820995,"self":"https://pharos.nih.gov/idg/api/v1/targets(10918)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":443,"href":"https://pharos.nih.gov/idg/api/v1/targets(10918)/properties"},"_links":{"count":2120,"href":"https://pharos.nih.gov/idg/api/v1/targets(10918)/links"},"_synonyms":{"count":175,"href":"https://pharos.nih.gov/idg/api/v1/targets(10918)/synonyms"},"_publications":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10918)/publications"},"_namespace":null},{"id":10919,"version":2,"created":1554934371000,"modified":1554934374000,"deprecated":false,"name":"Phosphatidylinositol glycan anchor biosynthesis class U protein","accession":"Q9H490","gene":"PIGU","description":"Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9804362635597441,"antibodyCount":20,"monoclonalCount":1,"pubmedCount":null,"jensenScore":9.331143,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.53439518038239,"pubTatorScore":0.4067428039170404,"self":"https://pharos.nih.gov/idg/api/v1/targets(10919)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":269,"href":"https://pharos.nih.gov/idg/api/v1/targets(10919)/properties"},"_links":{"count":953,"href":"https://pharos.nih.gov/idg/api/v1/targets(10919)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10919)/synonyms"},"_publications":{"count":15,"href":"https://pharos.nih.gov/idg/api/v1/targets(10919)/publications"},"_namespace":null},{"id":10920,"version":3,"created":1554934375000,"modified":1555039716000,"deprecated":false,"name":"Zinc finger protein GLI1","accession":"P08151","gene":"GLI1","description":"Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.","idgFamily":"Transcription Factor","idgTDL":"Tchem","novelty":-3.0430252226133643,"antibodyCount":450,"monoclonalCount":200,"pubmedCount":null,"jensenScore":1054.802919,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":41.463276399311006,"pubTatorScore":2.7897337739937336,"self":"https://pharos.nih.gov/idg/api/v1/targets(10920)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":627,"href":"https://pharos.nih.gov/idg/api/v1/targets(10920)/properties"},"_links":{"count":1153,"href":"https://pharos.nih.gov/idg/api/v1/targets(10920)/links"},"_synonyms":{"count":117,"href":"https://pharos.nih.gov/idg/api/v1/targets(10920)/synonyms"},"_publications":{"count":299,"href":"https://pharos.nih.gov/idg/api/v1/targets(10920)/publications"},"_namespace":null},{"id":10921,"version":2,"created":1554934382000,"modified":1554934385000,"deprecated":false,"name":"Ras-related C3 botulinum toxin substrate 3","accession":"P60763","gene":"RAC3","description":"Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.3034360646095256,"antibodyCount":56,"monoclonalCount":10,"pubmedCount":null,"jensenScore":1.493651,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.105875987232054,"pubTatorScore":1.8837846834948364,"self":"https://pharos.nih.gov/idg/api/v1/targets(10921)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":340,"href":"https://pharos.nih.gov/idg/api/v1/targets(10921)/properties"},"_links":{"count":932,"href":"https://pharos.nih.gov/idg/api/v1/targets(10921)/links"},"_synonyms":{"count":106,"href":"https://pharos.nih.gov/idg/api/v1/targets(10921)/synonyms"},"_publications":{"count":35,"href":"https://pharos.nih.gov/idg/api/v1/targets(10921)/publications"},"_namespace":null},{"id":10922,"version":2,"created":1554934385000,"modified":1554934396000,"deprecated":false,"name":"Glutathione S-transferase Mu 1","accession":"P09488","gene":"GSTM1","description":"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-3.278931698202841,"antibodyCount":469,"monoclonalCount":166,"pubmedCount":null,"jensenScore":1991.14482,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":40.07970357623665,"pubTatorScore":3.3252350484546427,"self":"https://pharos.nih.gov/idg/api/v1/targets(10922)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2444,"href":"https://pharos.nih.gov/idg/api/v1/targets(10922)/properties"},"_links":{"count":2228,"href":"https://pharos.nih.gov/idg/api/v1/targets(10922)/links"},"_synonyms":{"count":146,"href":"https://pharos.nih.gov/idg/api/v1/targets(10922)/synonyms"},"_publications":{"count":2053,"href":"https://pharos.nih.gov/idg/api/v1/targets(10922)/publications"},"_namespace":null},{"id":10923,"version":3,"created":1554934404000,"modified":1555039718000,"deprecated":false,"name":"SPARC","accession":"P09486","gene":"SPARC","description":"Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.10193883123024,"antibodyCount":543,"monoclonalCount":194,"pubmedCount":null,"jensenScore":1136.099337,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":43.302268971579025,"pubTatorScore":2.854105220734957,"self":"https://pharos.nih.gov/idg/api/v1/targets(10923)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":682,"href":"https://pharos.nih.gov/idg/api/v1/targets(10923)/properties"},"_links":{"count":1420,"href":"https://pharos.nih.gov/idg/api/v1/targets(10923)/links"},"_synonyms":{"count":138,"href":"https://pharos.nih.gov/idg/api/v1/targets(10923)/synonyms"},"_publications":{"count":267,"href":"https://pharos.nih.gov/idg/api/v1/targets(10923)/publications"},"_namespace":null},{"id":10924,"version":3,"created":1554934414000,"modified":1555039720000,"deprecated":false,"name":"Trans-acting T-cell-specific transcription factor GATA-3","accession":"P23771","gene":"GATA3","description":"Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-3.206775544218069,"antibodyCount":636,"monoclonalCount":208,"pubmedCount":null,"jensenScore":1568.191389,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":49.0601056380481,"pubTatorScore":2.760236331760682,"self":"https://pharos.nih.gov/idg/api/v1/targets(10924)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":784,"href":"https://pharos.nih.gov/idg/api/v1/targets(10924)/properties"},"_links":{"count":1276,"href":"https://pharos.nih.gov/idg/api/v1/targets(10924)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10924)/synonyms"},"_publications":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(10924)/publications"},"_namespace":null},{"id":10925,"version":3,"created":1554934423000,"modified":1555039723000,"deprecated":false,"name":"Actin, cytoplasmic 1","accession":"P60709","gene":"ACTB","description":"Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.529295570277212,"antibodyCount":1251,"monoclonalCount":544,"pubmedCount":null,"jensenScore":2830.74551,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":16,"knowledgeAvailability":58.626930946953685,"pubTatorScore":2.215071313758859,"self":"https://pharos.nih.gov/idg/api/v1/targets(10925)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":758,"href":"https://pharos.nih.gov/idg/api/v1/targets(10925)/properties"},"_links":{"count":1363,"href":"https://pharos.nih.gov/idg/api/v1/targets(10925)/links"},"_synonyms":{"count":161,"href":"https://pharos.nih.gov/idg/api/v1/targets(10925)/synonyms"},"_publications":{"count":297,"href":"https://pharos.nih.gov/idg/api/v1/targets(10925)/publications"},"_namespace":null},{"id":10926,"version":3,"created":1554934432000,"modified":1555039726000,"deprecated":false,"name":"Histone H2A deubiquitinase MYSM1","accession":"Q5VVJ2","gene":"MYSM1","description":"Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-1.7698695076393567,"antibodyCount":184,"monoclonalCount":1,"pubmedCount":null,"jensenScore":62.135918,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":34.854005162837844,"pubTatorScore":0.8573324361125862,"self":"https://pharos.nih.gov/idg/api/v1/targets(10926)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":438,"href":"https://pharos.nih.gov/idg/api/v1/targets(10926)/properties"},"_links":{"count":964,"href":"https://pharos.nih.gov/idg/api/v1/targets(10926)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10926)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10926)/publications"},"_namespace":null},{"id":10927,"version":2,"created":1554934437000,"modified":1554934437000,"deprecated":false,"name":"Putative uncharacterized protein encoded by LINC00305","accession":"Q7Z4B0","gene":"LINC00305","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":8.861181017535474,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10927)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10927)/properties"},"_links":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10927)/links"},"_synonyms":{"count":27,"href":"https://pharos.nih.gov/idg/api/v1/targets(10927)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10927)/publications"},"_namespace":null},{"id":10928,"version":2,"created":1554934437000,"modified":1554934441000,"deprecated":false,"name":"Nuclear pore complex protein Nup155","accession":"O75694","gene":"NUP155","description":"Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2267322396955536,"antibodyCount":91,"monoclonalCount":0,"pubmedCount":null,"jensenScore":15.080657,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":42.406797346926155,"pubTatorScore":0.9492290438757758,"self":"https://pharos.nih.gov/idg/api/v1/targets(10928)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":475,"href":"https://pharos.nih.gov/idg/api/v1/targets(10928)/properties"},"_links":{"count":1092,"href":"https://pharos.nih.gov/idg/api/v1/targets(10928)/links"},"_synonyms":{"count":124,"href":"https://pharos.nih.gov/idg/api/v1/targets(10928)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10928)/publications"},"_namespace":null},{"id":10929,"version":3,"created":1554934442000,"modified":1555039729000,"deprecated":false,"name":"Protein XRP2","accession":"O75695","gene":"RP2","description":"Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.4690033664276807,"antibodyCount":107,"monoclonalCount":46,"pubmedCount":null,"jensenScore":2.722222,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":24,"knowledgeAvailability":35.6374731007265,"pubTatorScore":2.2266865698821707,"self":"https://pharos.nih.gov/idg/api/v1/targets(10929)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":337,"href":"https://pharos.nih.gov/idg/api/v1/targets(10929)/properties"},"_links":{"count":1029,"href":"https://pharos.nih.gov/idg/api/v1/targets(10929)/links"},"_synonyms":{"count":96,"href":"https://pharos.nih.gov/idg/api/v1/targets(10929)/synonyms"},"_publications":{"count":67,"href":"https://pharos.nih.gov/idg/api/v1/targets(10929)/publications"},"_namespace":null},{"id":10930,"version":2,"created":1554934447000,"modified":1554934449000,"deprecated":false,"name":"Keratin-associated protein 5-8","accession":"O75690","gene":"KRTAP5-8","description":"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":1,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":10.106784724599878,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10930)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10930)/properties"},"_links":{"count":598,"href":"https://pharos.nih.gov/idg/api/v1/targets(10930)/links"},"_synonyms":{"count":48,"href":"https://pharos.nih.gov/idg/api/v1/targets(10930)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10930)/publications"},"_namespace":null},{"id":10931,"version":2,"created":1554934450000,"modified":1554934453000,"deprecated":false,"name":"Small subunit processome component 20 homolog","accession":"O75691","gene":"UTP20","description":"Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.390072581533623,"antibodyCount":35,"monoclonalCount":0,"pubmedCount":null,"jensenScore":24.108707,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":33.726004091545796,"pubTatorScore":1.1069271111313397,"self":"https://pharos.nih.gov/idg/api/v1/targets(10931)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":287,"href":"https://pharos.nih.gov/idg/api/v1/targets(10931)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(10931)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10931)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10931)/publications"},"_namespace":null},{"id":10932,"version":3,"created":1554934454000,"modified":1555039733000,"deprecated":false,"name":"Cadherin-5","accession":"P33151","gene":"CDH5","description":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.982069767136441,"antibodyCount":731,"monoclonalCount":356,"pubmedCount":null,"jensenScore":896.780496,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":68,"knowledgeAvailability":42.84345449027989,"pubTatorScore":2.7917707286262528,"self":"https://pharos.nih.gov/idg/api/v1/targets(10932)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":596,"href":"https://pharos.nih.gov/idg/api/v1/targets(10932)/properties"},"_links":{"count":1247,"href":"https://pharos.nih.gov/idg/api/v1/targets(10932)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10932)/synonyms"},"_publications":{"count":207,"href":"https://pharos.nih.gov/idg/api/v1/targets(10932)/publications"},"_namespace":null},{"id":10933,"version":3,"created":1554934461000,"modified":1555039735000,"deprecated":false,"name":"Fucose mutarotase","accession":"A2VDF0","gene":"FUOM","description":"Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.0,"antibodyCount":36,"monoclonalCount":0,"pubmedCount":null,"jensenScore":9.636364,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":20.391326535612684,"pubTatorScore":0.8346325851509947,"self":"https://pharos.nih.gov/idg/api/v1/targets(10933)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":220,"href":"https://pharos.nih.gov/idg/api/v1/targets(10933)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(10933)/links"},"_synonyms":{"count":79,"href":"https://pharos.nih.gov/idg/api/v1/targets(10933)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10933)/publications"},"_namespace":null},{"id":10934,"version":3,"created":1554934464000,"modified":1555039736000,"deprecated":false,"name":"WD repeat-containing protein 44","accession":"Q5JSH3","gene":"WDR44","description":"Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4617735641452001,"antibodyCount":26,"monoclonalCount":0,"pubmedCount":null,"jensenScore":3.306197,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":33.10270895660997,"pubTatorScore":0.2632413558119412,"self":"https://pharos.nih.gov/idg/api/v1/targets(10934)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":373,"href":"https://pharos.nih.gov/idg/api/v1/targets(10934)/properties"},"_links":{"count":1067,"href":"https://pharos.nih.gov/idg/api/v1/targets(10934)/links"},"_synonyms":{"count":116,"href":"https://pharos.nih.gov/idg/api/v1/targets(10934)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10934)/publications"},"_namespace":null},{"id":10935,"version":2,"created":1554934468000,"modified":1554934473000,"deprecated":false,"name":"Vesicle-fusing ATPase","accession":"P46459","gene":"NSF","description":"Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.9327059136840234,"antibodyCount":206,"monoclonalCount":34,"pubmedCount":null,"jensenScore":688.766944,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.110643731077865,"pubTatorScore":2.956242744681744,"self":"https://pharos.nih.gov/idg/api/v1/targets(10935)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":519,"href":"https://pharos.nih.gov/idg/api/v1/targets(10935)/properties"},"_links":{"count":1215,"href":"https://pharos.nih.gov/idg/api/v1/targets(10935)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10935)/synonyms"},"_publications":{"count":68,"href":"https://pharos.nih.gov/idg/api/v1/targets(10935)/publications"},"_namespace":null},{"id":10936,"version":2,"created":1554934474000,"modified":1554934477000,"deprecated":false,"name":"Arf-GAP with dual PH domain-containing protein 1","accession":"O75689","gene":"ADAP1","description":"GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.285517760912926,"antibodyCount":160,"monoclonalCount":8,"pubmedCount":null,"jensenScore":23.766365,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.43574033253966,"pubTatorScore":1.3942765092488827,"self":"https://pharos.nih.gov/idg/api/v1/targets(10936)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":306,"href":"https://pharos.nih.gov/idg/api/v1/targets(10936)/properties"},"_links":{"count":815,"href":"https://pharos.nih.gov/idg/api/v1/targets(10936)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10936)/synonyms"},"_publications":{"count":34,"href":"https://pharos.nih.gov/idg/api/v1/targets(10936)/publications"},"_namespace":null},{"id":10937,"version":3,"created":1554934478000,"modified":1555039738000,"deprecated":false,"name":"Protein phosphatase 1B","accession":"O75688","gene":"PPM1B","description":"Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.5513629254469712,"antibodyCount":200,"monoclonalCount":110,"pubmedCount":null,"jensenScore":36.258794,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":47.31183242106353,"pubTatorScore":1.3663043459479407,"self":"https://pharos.nih.gov/idg/api/v1/targets(10937)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":429,"href":"https://pharos.nih.gov/idg/api/v1/targets(10937)/properties"},"_links":{"count":1196,"href":"https://pharos.nih.gov/idg/api/v1/targets(10937)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10937)/synonyms"},"_publications":{"count":41,"href":"https://pharos.nih.gov/idg/api/v1/targets(10937)/publications"},"_namespace":null},{"id":10938,"version":2,"created":1554934486000,"modified":1554934489000,"deprecated":false,"name":"Surfeit locus protein 6","accession":"O75683","gene":"SURF6","description":"Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.1794560363145394,"antibodyCount":101,"monoclonalCount":6,"pubmedCount":null,"jensenScore":18.208461,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":31.536046852634037,"pubTatorScore":1.0243944070117306,"self":"https://pharos.nih.gov/idg/api/v1/targets(10938)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":388,"href":"https://pharos.nih.gov/idg/api/v1/targets(10938)/properties"},"_links":{"count":1045,"href":"https://pharos.nih.gov/idg/api/v1/targets(10938)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10938)/synonyms"},"_publications":{"count":32,"href":"https://pharos.nih.gov/idg/api/v1/targets(10938)/publications"},"_namespace":null},{"id":10939,"version":3,"created":1554934490000,"modified":1555039739000,"deprecated":false,"name":"Corticosteroid-binding globulin","accession":"P08185","gene":"SERPINA6","description":"Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.","idgFamily":"Non-IDG","idgTDL":"Tchem","novelty":-3.045299310382352,"antibodyCount":309,"monoclonalCount":38,"pubmedCount":null,"jensenScore":1153.052716,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":27.93077833111394,"pubTatorScore":2.9214722218426963,"self":"https://pharos.nih.gov/idg/api/v1/targets(10939)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":357,"href":"https://pharos.nih.gov/idg/api/v1/targets(10939)/properties"},"_links":{"count":703,"href":"https://pharos.nih.gov/idg/api/v1/targets(10939)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(10939)/synonyms"},"_publications":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10939)/publications"},"_namespace":null},{"id":10940,"version":3,"created":1554934526000,"modified":1554934742000,"deprecated":false,"name":"Multidrug resistance protein 1","accession":"P08183","gene":"ABCB1","description":"Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.","idgFamily":"Transporter","idgTDL":"Tchem","novelty":-3.6182713814648895,"antibodyCount":875,"monoclonalCount":604,"pubmedCount":null,"jensenScore":4039.431296,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.674523510254375,"pubTatorScore":3.978918421850838,"self":"https://pharos.nih.gov/idg/api/v1/targets(10940)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":2424,"href":"https://pharos.nih.gov/idg/api/v1/targets(10940)/properties"},"_links":{"count":3279,"href":"https://pharos.nih.gov/idg/api/v1/targets(10940)/links"},"_synonyms":{"count":471,"href":"https://pharos.nih.gov/idg/api/v1/targets(10940)/synonyms"},"_publications":{"count":2053,"href":"https://pharos.nih.gov/idg/api/v1/targets(10940)/publications"},"_namespace":null},{"id":10941,"version":2,"created":1554934748000,"modified":1554934750000,"deprecated":false,"name":"G-protein coupled receptor 12","accession":"P47775","gene":"GPR12","description":"Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.","idgFamily":"GPCR","idgTDL":"Tbio","novelty":-1.1153372661676277,"antibodyCount":162,"monoclonalCount":4,"pubmedCount":null,"jensenScore":13.551155,"patentCount":6215,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.055592505991516,"pubTatorScore":0.9158267958430123,"self":"https://pharos.nih.gov/idg/api/v1/targets(10941)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(10941)/properties"},"_links":{"count":652,"href":"https://pharos.nih.gov/idg/api/v1/targets(10941)/links"},"_synonyms":{"count":76,"href":"https://pharos.nih.gov/idg/api/v1/targets(10941)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10941)/publications"},"_namespace":null},{"id":10942,"version":2,"created":1554934751000,"modified":1554934755000,"deprecated":false,"name":"Myelin and lymphocyte protein","accession":"P21145","gene":"MAL","description":"Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.387100805745561,"antibodyCount":164,"monoclonalCount":7,"pubmedCount":null,"jensenScore":22.036085,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.912150057181528,"pubTatorScore":1.939398971335478,"self":"https://pharos.nih.gov/idg/api/v1/targets(10942)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":268,"href":"https://pharos.nih.gov/idg/api/v1/targets(10942)/properties"},"_links":{"count":894,"href":"https://pharos.nih.gov/idg/api/v1/targets(10942)/links"},"_synonyms":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10942)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10942)/publications"},"_namespace":null},{"id":10943,"version":2,"created":1554934756000,"modified":1554934759000,"deprecated":false,"name":"Polyserase-2","accession":"Q5K4E3","gene":"PRSS36","description":"Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":0.06214790530119616,"antibodyCount":56,"monoclonalCount":0,"pubmedCount":null,"jensenScore":1.298368,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.441240502869373,"pubTatorScore":0.22184883647524403,"self":"https://pharos.nih.gov/idg/api/v1/targets(10943)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":213,"href":"https://pharos.nih.gov/idg/api/v1/targets(10943)/properties"},"_links":{"count":781,"href":"https://pharos.nih.gov/idg/api/v1/targets(10943)/links"},"_synonyms":{"count":92,"href":"https://pharos.nih.gov/idg/api/v1/targets(10943)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10943)/publications"},"_namespace":null},{"id":10944,"version":3,"created":1554934759000,"modified":1555039741000,"deprecated":false,"name":"Ret finger protein-like 2","accession":"O75678","gene":"RFPL2","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.7781512503836436,"antibodyCount":60,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.066667,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":14.364986343746757,"pubTatorScore":-0.3979400086720376,"self":"https://pharos.nih.gov/idg/api/v1/targets(10944)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10944)/properties"},"_links":{"count":559,"href":"https://pharos.nih.gov/idg/api/v1/targets(10944)/links"},"_synonyms":{"count":91,"href":"https://pharos.nih.gov/idg/api/v1/targets(10944)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10944)/publications"},"_namespace":null},{"id":10945,"version":3,"created":1554934762000,"modified":1555039742000,"deprecated":false,"name":"Ret finger protein-like 3","accession":"O75679","gene":"RFPL3","description":"(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.5006023556359543,"antibodyCount":95,"monoclonalCount":20,"pubmedCount":null,"jensenScore":2.989744,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":5,"knowledgeAvailability":14.66100230340397,"pubTatorScore":0.34895348316108726,"self":"https://pharos.nih.gov/idg/api/v1/targets(10945)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10945)/properties"},"_links":{"count":477,"href":"https://pharos.nih.gov/idg/api/v1/targets(10945)/links"},"_synonyms":{"count":88,"href":"https://pharos.nih.gov/idg/api/v1/targets(10945)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10945)/publications"},"_namespace":null},{"id":10946,"version":3,"created":1554934764000,"modified":1555039744000,"deprecated":false,"name":"Ribosomal protein S6 kinase alpha-4","accession":"O75676","gene":"RPS6KA4","description":"Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-1.0924616481575793,"antibodyCount":178,"monoclonalCount":10,"pubmedCount":null,"jensenScore":12.605557,"patentCount":8100,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":10,"knowledgeAvailability":46.770437770706934,"pubTatorScore":0.9645670169721082,"self":"https://pharos.nih.gov/idg/api/v1/targets(10946)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":452,"href":"https://pharos.nih.gov/idg/api/v1/targets(10946)/properties"},"_links":{"count":1051,"href":"https://pharos.nih.gov/idg/api/v1/targets(10946)/links"},"_synonyms":{"count":103,"href":"https://pharos.nih.gov/idg/api/v1/targets(10946)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10946)/publications"},"_namespace":null},{"id":10947,"version":3,"created":1554934769000,"modified":1555039746000,"deprecated":false,"name":"Histone H1t","accession":"P22492","gene":"HIST1H1T","description":"Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.9230549653615667,"antibodyCount":37,"monoclonalCount":0,"pubmedCount":null,"jensenScore":90.791621,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":73,"knowledgeAvailability":27.20915954485706,"pubTatorScore":1.6271788238705898,"self":"https://pharos.nih.gov/idg/api/v1/targets(10947)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":199,"href":"https://pharos.nih.gov/idg/api/v1/targets(10947)/properties"},"_links":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(10947)/links"},"_synonyms":{"count":81,"href":"https://pharos.nih.gov/idg/api/v1/targets(10947)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10947)/publications"},"_namespace":null},{"id":10948,"version":2,"created":1554934771000,"modified":1554934772000,"deprecated":false,"name":"Ret finger protein-like 1","accession":"O75677","gene":"RFPL1","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.0369835648055217,"antibodyCount":28,"monoclonalCount":11,"pubmedCount":null,"jensenScore":1.894968,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":13.610521041754916,"pubTatorScore":0.3424226808222063,"self":"https://pharos.nih.gov/idg/api/v1/targets(10948)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":149,"href":"https://pharos.nih.gov/idg/api/v1/targets(10948)/properties"},"_links":{"count":338,"href":"https://pharos.nih.gov/idg/api/v1/targets(10948)/links"},"_synonyms":{"count":86,"href":"https://pharos.nih.gov/idg/api/v1/targets(10948)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10948)/publications"},"_namespace":null},{"id":10949,"version":2,"created":1554934772000,"modified":1554934776000,"deprecated":false,"name":"TOM1-like protein 1","accession":"O75674","gene":"TOM1L1","description":"Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8825582026409362,"antibodyCount":177,"monoclonalCount":10,"pubmedCount":null,"jensenScore":9.682407,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.822617673364434,"pubTatorScore":1.0264910995503145,"self":"https://pharos.nih.gov/idg/api/v1/targets(10949)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(10949)/properties"},"_links":{"count":973,"href":"https://pharos.nih.gov/idg/api/v1/targets(10949)/links"},"_synonyms":{"count":113,"href":"https://pharos.nih.gov/idg/api/v1/targets(10949)/synonyms"},"_publications":{"count":38,"href":"https://pharos.nih.gov/idg/api/v1/targets(10949)/publications"},"_namespace":null},{"id":10950,"version":2,"created":1554934777000,"modified":1554934779000,"deprecated":false,"name":"Neurexin-1-beta","accession":"P58400","gene":"NRXN1","description":"Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8880727717802437,"antibodyCount":174,"monoclonalCount":22,"pubmedCount":null,"jensenScore":125.142705,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.37672476487127,"pubTatorScore":2.0715189510306007,"self":"https://pharos.nih.gov/idg/api/v1/targets(10950)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":321,"href":"https://pharos.nih.gov/idg/api/v1/targets(10950)/properties"},"_links":{"count":368,"href":"https://pharos.nih.gov/idg/api/v1/targets(10950)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10950)/synonyms"},"_publications":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10950)/publications"},"_namespace":null},{"id":10951,"version":2,"created":1554934780000,"modified":1554934780000,"deprecated":false,"name":"Putative 3-phosphoinositide-dependent protein kinase 2","accession":"Q6A1A2","gene":"PDPK2P","description":"Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity).","idgFamily":"Kinase","idgTDL":"Tdark","novelty":-2.120250016231711,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":204.919768,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.946639519172035,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10951)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":49,"href":"https://pharos.nih.gov/idg/api/v1/targets(10951)/properties"},"_links":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10951)/links"},"_synonyms":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10951)/synonyms"},"_publications":null,"_namespace":null},{"id":10952,"version":2,"created":1554934781000,"modified":1554934782000,"deprecated":false,"name":"Neurexin-2-beta","accession":"P58401","gene":"NRXN2","description":"Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8893867913017199,"antibodyCount":42,"monoclonalCount":0,"pubmedCount":null,"jensenScore":10.036677,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.302312123657224,"pubTatorScore":0.7590379254339334,"self":"https://pharos.nih.gov/idg/api/v1/targets(10952)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10952)/properties"},"_links":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(10952)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10952)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10952)/publications"},"_namespace":null},{"id":10953,"version":2,"created":1554934782000,"modified":1554934787000,"deprecated":false,"name":"Long-chain-fatty-acid--CoA ligase 1","accession":"P33121","gene":"ACSL1","description":"Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.598501237050828,"antibodyCount":222,"monoclonalCount":14,"pubmedCount":null,"jensenScore":388.527209,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":47.33527945683444,"pubTatorScore":1.9895492579378795,"self":"https://pharos.nih.gov/idg/api/v1/targets(10953)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":427,"href":"https://pharos.nih.gov/idg/api/v1/targets(10953)/properties"},"_links":{"count":1101,"href":"https://pharos.nih.gov/idg/api/v1/targets(10953)/links"},"_synonyms":{"count":131,"href":"https://pharos.nih.gov/idg/api/v1/targets(10953)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10953)/publications"},"_namespace":null},{"id":10954,"version":2,"created":1554934788000,"modified":1554934791000,"deprecated":false,"name":"Zinc finger protein 93","accession":"P35789","gene":"ZNF93","description":"Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).","idgFamily":"Transcription Factor","idgTDL":"Tbio","novelty":-0.18799048145060876,"antibodyCount":107,"monoclonalCount":2,"pubmedCount":null,"jensenScore":1.855128,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.628725848865376,"pubTatorScore":0.12493862803466593,"self":"https://pharos.nih.gov/idg/api/v1/targets(10954)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":240,"href":"https://pharos.nih.gov/idg/api/v1/targets(10954)/properties"},"_links":{"count":803,"href":"https://pharos.nih.gov/idg/api/v1/targets(10954)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10954)/synonyms"},"_publications":{"count":11,"href":"https://pharos.nih.gov/idg/api/v1/targets(10954)/publications"},"_namespace":null},{"id":10955,"version":3,"created":1554934792000,"modified":1555039747000,"deprecated":false,"name":"Glutathione S-transferase Mu 5","accession":"P46439","gene":"GSTM5","description":"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.1413705998306427,"antibodyCount":153,"monoclonalCount":35,"pubmedCount":null,"jensenScore":11.719076,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":30.854493131640005,"pubTatorScore":1.0752359462985606,"self":"https://pharos.nih.gov/idg/api/v1/targets(10955)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":293,"href":"https://pharos.nih.gov/idg/api/v1/targets(10955)/properties"},"_links":{"count":923,"href":"https://pharos.nih.gov/idg/api/v1/targets(10955)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10955)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10955)/publications"},"_namespace":null},{"id":10956,"version":2,"created":1554934796000,"modified":1554934798000,"deprecated":false,"name":"Coiled-coil domain-containing protein 184","accession":"Q52MB2","gene":"CCDC184","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.3010299956639812,"antibodyCount":46,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":16.774584917430648,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10956)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(10956)/properties"},"_links":{"count":759,"href":"https://pharos.nih.gov/idg/api/v1/targets(10956)/links"},"_synonyms":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10956)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10956)/publications"},"_namespace":null},{"id":10957,"version":2,"created":1554934799000,"modified":1554934805000,"deprecated":false,"name":"Choline kinase alpha","accession":"P35790","gene":"CHKA","description":"Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.","idgFamily":"Kinase","idgTDL":"Tchem","novelty":-2.4722657263508987,"antibodyCount":159,"monoclonalCount":4,"pubmedCount":null,"jensenScore":275.142583,"patentCount":30263,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.675489655109246,"pubTatorScore":2.2025550744885347,"self":"https://pharos.nih.gov/idg/api/v1/targets(10957)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":376,"href":"https://pharos.nih.gov/idg/api/v1/targets(10957)/properties"},"_links":{"count":941,"href":"https://pharos.nih.gov/idg/api/v1/targets(10957)/links"},"_synonyms":{"count":155,"href":"https://pharos.nih.gov/idg/api/v1/targets(10957)/synonyms"},"_publications":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10957)/publications"},"_namespace":null},{"id":10958,"version":3,"created":1554934806000,"modified":1555039754000,"deprecated":false,"name":"4F2 cell-surface antigen heavy chain","accession":"P08195","gene":"SLC3A2","description":"Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).","idgFamily":"Transporter","idgTDL":"Tbio","novelty":-2.82471438017395,"antibodyCount":604,"monoclonalCount":337,"pubmedCount":null,"jensenScore":653.582291,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":31,"knowledgeAvailability":51.90346162810415,"pubTatorScore":2.377266434057614,"self":"https://pharos.nih.gov/idg/api/v1/targets(10958)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":585,"href":"https://pharos.nih.gov/idg/api/v1/targets(10958)/properties"},"_links":{"count":1286,"href":"https://pharos.nih.gov/idg/api/v1/targets(10958)/links"},"_synonyms":{"count":122,"href":"https://pharos.nih.gov/idg/api/v1/targets(10958)/synonyms"},"_publications":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10958)/publications"},"_namespace":null},{"id":10959,"version":3,"created":1554934814000,"modified":1555039755000,"deprecated":false,"name":"Interleukin-1 receptor-associated kinase 1-binding protein 1","accession":"Q5VVH5","gene":"IRAK1BP1","description":"Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-1.3834413111916157,"antibodyCount":44,"monoclonalCount":3,"pubmedCount":null,"jensenScore":24.358766,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":27.79783121705127,"pubTatorScore":0.7953972305554939,"self":"https://pharos.nih.gov/idg/api/v1/targets(10959)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":209,"href":"https://pharos.nih.gov/idg/api/v1/targets(10959)/properties"},"_links":{"count":820,"href":"https://pharos.nih.gov/idg/api/v1/targets(10959)/links"},"_synonyms":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10959)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10959)/publications"},"_namespace":null},{"id":10960,"version":2,"created":1554934818000,"modified":1554934825000,"deprecated":false,"name":"Oral-facial-digital syndrome 1 protein","accession":"O75665","gene":"OFD1","description":"Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.9122483877364764,"antibodyCount":54,"monoclonalCount":3,"pubmedCount":null,"jensenScore":84.640228,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":37.19829835842413,"pubTatorScore":1.8578374681804066,"self":"https://pharos.nih.gov/idg/api/v1/targets(10960)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":469,"href":"https://pharos.nih.gov/idg/api/v1/targets(10960)/properties"},"_links":{"count":1336,"href":"https://pharos.nih.gov/idg/api/v1/targets(10960)/links"},"_synonyms":{"count":98,"href":"https://pharos.nih.gov/idg/api/v1/targets(10960)/synonyms"},"_publications":{"count":64,"href":"https://pharos.nih.gov/idg/api/v1/targets(10960)/publications"},"_namespace":null},{"id":10961,"version":2,"created":1554934826000,"modified":1554934830000,"deprecated":false,"name":"Protein MON2 homolog","accession":"Q7Z3U7","gene":"MON2","description":"May be required for traffic between late Golgi and early endosomes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5238227686313628,"antibodyCount":19,"monoclonalCount":0,"pubmedCount":null,"jensenScore":34.782996,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.91155000917473,"pubTatorScore":1.2322985713681345,"self":"https://pharos.nih.gov/idg/api/v1/targets(10961)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":275,"href":"https://pharos.nih.gov/idg/api/v1/targets(10961)/properties"},"_links":{"count":931,"href":"https://pharos.nih.gov/idg/api/v1/targets(10961)/links"},"_synonyms":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10961)/synonyms"},"_publications":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10961)/publications"},"_namespace":null},{"id":10962,"version":3,"created":1554934830000,"modified":1555039757000,"deprecated":false,"name":"GPI mannosyltransferase 1","accession":"Q9H3S5","gene":"PIGM","description":"Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.5411085970274674,"antibodyCount":62,"monoclonalCount":2,"pubmedCount":null,"jensenScore":33.201787,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":31.62700860640872,"pubTatorScore":0.9085488179495075,"self":"https://pharos.nih.gov/idg/api/v1/targets(10962)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":239,"href":"https://pharos.nih.gov/idg/api/v1/targets(10962)/properties"},"_links":{"count":835,"href":"https://pharos.nih.gov/idg/api/v1/targets(10962)/links"},"_synonyms":{"count":72,"href":"https://pharos.nih.gov/idg/api/v1/targets(10962)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10962)/publications"},"_namespace":null},{"id":10963,"version":2,"created":1554934835000,"modified":1554934838000,"deprecated":false,"name":"TIP41-like protein","accession":"O75663","gene":"TIPRL","description":"May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.560963991135525,"antibodyCount":154,"monoclonalCount":7,"pubmedCount":null,"jensenScore":34.819567,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":32.4825461948929,"pubTatorScore":2.7148521180502025,"self":"https://pharos.nih.gov/idg/api/v1/targets(10963)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":377,"href":"https://pharos.nih.gov/idg/api/v1/targets(10963)/properties"},"_links":{"count":1030,"href":"https://pharos.nih.gov/idg/api/v1/targets(10963)/links"},"_synonyms":{"count":83,"href":"https://pharos.nih.gov/idg/api/v1/targets(10963)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10963)/publications"},"_namespace":null},{"id":10964,"version":2,"created":1554934839000,"modified":1554934843000,"deprecated":false,"name":"Charged multivesicular body protein 4b","accession":"Q9H444","gene":"CHMP4B","description":"(Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.6467784072506764,"antibodyCount":106,"monoclonalCount":2,"pubmedCount":null,"jensenScore":4.550224,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":36.73801790682019,"pubTatorScore":1.3633947407262146,"self":"https://pharos.nih.gov/idg/api/v1/targets(10964)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":467,"href":"https://pharos.nih.gov/idg/api/v1/targets(10964)/properties"},"_links":{"count":1140,"href":"https://pharos.nih.gov/idg/api/v1/targets(10964)/links"},"_synonyms":{"count":100,"href":"https://pharos.nih.gov/idg/api/v1/targets(10964)/synonyms"},"_publications":{"count":65,"href":"https://pharos.nih.gov/idg/api/v1/targets(10964)/publications"},"_namespace":null},{"id":10965,"version":2,"created":1554934844000,"modified":1554934848000,"deprecated":false,"name":"Thiamin pyrophosphokinase 1","accession":"Q9H3S4","gene":"TPK1","description":"Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.","idgFamily":"Kinase","idgTDL":"Tbio","novelty":-1.5431800172094459,"antibodyCount":114,"monoclonalCount":5,"pubmedCount":null,"jensenScore":34.415706,"patentCount":4586,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.83219357746884,"pubTatorScore":1.4521699032028845,"self":"https://pharos.nih.gov/idg/api/v1/targets(10965)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":364,"href":"https://pharos.nih.gov/idg/api/v1/targets(10965)/properties"},"_links":{"count":977,"href":"https://pharos.nih.gov/idg/api/v1/targets(10965)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(10965)/synonyms"},"_publications":{"count":25,"href":"https://pharos.nih.gov/idg/api/v1/targets(10965)/publications"},"_namespace":null},{"id":10966,"version":2,"created":1554934849000,"modified":1554934853000,"deprecated":false,"name":"Tyrosine-protein phosphatase non-receptor type 23","accession":"Q9H3S7","gene":"PTPN23","description":"Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.4152734535784406,"antibodyCount":103,"monoclonalCount":0,"pubmedCount":null,"jensenScore":29.601617,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":34.903383021647194,"pubTatorScore":1.3506613513570958,"self":"https://pharos.nih.gov/idg/api/v1/targets(10966)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":463,"href":"https://pharos.nih.gov/idg/api/v1/targets(10966)/properties"},"_links":{"count":1109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10966)/links"},"_synonyms":{"count":145,"href":"https://pharos.nih.gov/idg/api/v1/targets(10966)/synonyms"},"_publications":{"count":46,"href":"https://pharos.nih.gov/idg/api/v1/targets(10966)/publications"},"_namespace":null},{"id":10967,"version":2,"created":1554934854000,"modified":1554934858000,"deprecated":false,"name":"RWD domain-containing protein 1","accession":"Q9H446","gene":"RWDD1","description":"Protects DRG2 from proteolytic degradation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.4698220170638992,"antibodyCount":93,"monoclonalCount":3,"pubmedCount":null,"jensenScore":2.869318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":28.2991593888952,"pubTatorScore":-0.6989700043360187,"self":"https://pharos.nih.gov/idg/api/v1/targets(10967)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":378,"href":"https://pharos.nih.gov/idg/api/v1/targets(10967)/properties"},"_links":{"count":1096,"href":"https://pharos.nih.gov/idg/api/v1/targets(10967)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10967)/synonyms"},"_publications":{"count":14,"href":"https://pharos.nih.gov/idg/api/v1/targets(10967)/publications"},"_namespace":null},{"id":10968,"version":3,"created":1554934859000,"modified":1555039758000,"deprecated":false,"name":"Semaphorin-4A","accession":"Q9H3S1","gene":"SEMA4A","description":"Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.660811600166812,"antibodyCount":292,"monoclonalCount":73,"pubmedCount":null,"jensenScore":49.422233,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":7,"knowledgeAvailability":35.39964149583614,"pubTatorScore":1.4668025305937622,"self":"https://pharos.nih.gov/idg/api/v1/targets(10968)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":289,"href":"https://pharos.nih.gov/idg/api/v1/targets(10968)/properties"},"_links":{"count":882,"href":"https://pharos.nih.gov/idg/api/v1/targets(10968)/links"},"_synonyms":{"count":119,"href":"https://pharos.nih.gov/idg/api/v1/targets(10968)/synonyms"},"_publications":{"count":28,"href":"https://pharos.nih.gov/idg/api/v1/targets(10968)/publications"},"_namespace":null},{"id":10969,"version":3,"created":1554934865000,"modified":1555039759000,"deprecated":false,"name":"Transmembrane protease serine 5","accession":"Q9H3S3","gene":"TMPRSS5","description":"May play a role in hearing.","idgFamily":"Enzyme","idgTDL":"Tdark","novelty":-0.4008257006010289,"antibodyCount":200,"monoclonalCount":51,"pubmedCount":null,"jensenScore":3.008225,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":26.22731799710896,"pubTatorScore":0.2304489213782739,"self":"https://pharos.nih.gov/idg/api/v1/targets(10969)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":210,"href":"https://pharos.nih.gov/idg/api/v1/targets(10969)/properties"},"_links":{"count":730,"href":"https://pharos.nih.gov/idg/api/v1/targets(10969)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10969)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10969)/publications"},"_namespace":null},{"id":10970,"version":3,"created":1554934868000,"modified":1555039760000,"deprecated":false,"name":"Tyrosine-protein phosphatase non-receptor type 12","accession":"Q05209","gene":"PTPN12","description":"Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.817164668091213,"antibodyCount":125,"monoclonalCount":32,"pubmedCount":null,"jensenScore":68.846967,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":49.54945884631215,"pubTatorScore":1.8245649134482875,"self":"https://pharos.nih.gov/idg/api/v1/targets(10970)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":510,"href":"https://pharos.nih.gov/idg/api/v1/targets(10970)/properties"},"_links":{"count":1164,"href":"https://pharos.nih.gov/idg/api/v1/targets(10970)/links"},"_synonyms":{"count":134,"href":"https://pharos.nih.gov/idg/api/v1/targets(10970)/synonyms"},"_publications":{"count":93,"href":"https://pharos.nih.gov/idg/api/v1/targets(10970)/publications"},"_namespace":null},{"id":10971,"version":2,"created":1554934874000,"modified":1554934878000,"deprecated":false,"name":"Complement C4-B","accession":"P0C0L5","gene":"C4B","description":"Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.9938078849767242,"antibodyCount":185,"monoclonalCount":83,"pubmedCount":null,"jensenScore":1011.929162,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":24.49251817362639,"pubTatorScore":2.7807426432466342,"self":"https://pharos.nih.gov/idg/api/v1/targets(10971)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":447,"href":"https://pharos.nih.gov/idg/api/v1/targets(10971)/properties"},"_links":{"count":966,"href":"https://pharos.nih.gov/idg/api/v1/targets(10971)/links"},"_synonyms":{"count":274,"href":"https://pharos.nih.gov/idg/api/v1/targets(10971)/synonyms"},"_publications":{"count":170,"href":"https://pharos.nih.gov/idg/api/v1/targets(10971)/publications"},"_namespace":null},{"id":10972,"version":2,"created":1554934879000,"modified":1554934882000,"deprecated":false,"name":"Complement C4-A","accession":"P0C0L4","gene":"C4B","description":"Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-3.0453764437282143,"antibodyCount":297,"monoclonalCount":147,"pubmedCount":null,"jensenScore":1109.826196,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.7807426432466342,"self":"https://pharos.nih.gov/idg/api/v1/targets(10972)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":481,"href":"https://pharos.nih.gov/idg/api/v1/targets(10972)/properties"},"_links":{"count":1027,"href":"https://pharos.nih.gov/idg/api/v1/targets(10972)/links"},"_synonyms":{"count":290,"href":"https://pharos.nih.gov/idg/api/v1/targets(10972)/synonyms"},"_publications":{"count":184,"href":"https://pharos.nih.gov/idg/api/v1/targets(10972)/publications"},"_namespace":null},{"id":10973,"version":2,"created":1554934884000,"modified":1554934887000,"deprecated":false,"name":"Ubiquitin-protein ligase E3B","accession":"Q7Z3V4","gene":"UBE3B","description":"E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.216998804341424,"antibodyCount":44,"monoclonalCount":4,"pubmedCount":null,"jensenScore":129.229624,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":43.361535373197206,"pubTatorScore":1.2354683485130333,"self":"https://pharos.nih.gov/idg/api/v1/targets(10973)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":389,"href":"https://pharos.nih.gov/idg/api/v1/targets(10973)/properties"},"_links":{"count":990,"href":"https://pharos.nih.gov/idg/api/v1/targets(10973)/links"},"_synonyms":{"count":121,"href":"https://pharos.nih.gov/idg/api/v1/targets(10973)/synonyms"},"_publications":{"count":22,"href":"https://pharos.nih.gov/idg/api/v1/targets(10973)/publications"},"_namespace":null},{"id":10974,"version":4,"created":1554934888000,"modified":1555039761000,"deprecated":false,"name":"Peroxisome proliferator-activated receptor alpha","accession":"Q07869","gene":"PPARA","description":"Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.","idgFamily":"Nuclear Receptor","idgTDL":"Tclin","novelty":-3.3717643774109156,"antibodyCount":501,"monoclonalCount":142,"pubmedCount":null,"jensenScore":2457.851823,"patentCount":54945,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":1,"knowledgeAvailability":53.71810704232045,"pubTatorScore":3.430897679591922,"self":"https://pharos.nih.gov/idg/api/v1/targets(10974)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":986,"href":"https://pharos.nih.gov/idg/api/v1/targets(10974)/properties"},"_links":{"count":1772,"href":"https://pharos.nih.gov/idg/api/v1/targets(10974)/links"},"_synonyms":{"count":225,"href":"https://pharos.nih.gov/idg/api/v1/targets(10974)/synonyms"},"_publications":{"count":525,"href":"https://pharos.nih.gov/idg/api/v1/targets(10974)/publications"},"_namespace":null},{"id":10975,"version":3,"created":1554934992000,"modified":1555039765000,"deprecated":false,"name":"Kinesin light chain 1","accession":"Q07866","gene":"KLC1","description":"Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.1759790084398762,"antibodyCount":180,"monoclonalCount":31,"pubmedCount":null,"jensenScore":25.545823,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":8,"knowledgeAvailability":41.559256816402396,"pubTatorScore":1.625140860456594,"self":"https://pharos.nih.gov/idg/api/v1/targets(10975)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":358,"href":"https://pharos.nih.gov/idg/api/v1/targets(10975)/properties"},"_links":{"count":1171,"href":"https://pharos.nih.gov/idg/api/v1/targets(10975)/links"},"_synonyms":{"count":180,"href":"https://pharos.nih.gov/idg/api/v1/targets(10975)/synonyms"},"_publications":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(10975)/publications"},"_namespace":null},{"id":10976,"version":3,"created":1554934997000,"modified":1555039767000,"deprecated":false,"name":"Zinc finger protein 571","accession":"Q7Z3V5","gene":"ZNF571","description":"May be involved in transcriptional regulation.","idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":null,"antibodyCount":78,"monoclonalCount":3,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":24.149342273015325,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10976)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":238,"href":"https://pharos.nih.gov/idg/api/v1/targets(10976)/properties"},"_links":{"count":811,"href":"https://pharos.nih.gov/idg/api/v1/targets(10976)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10976)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10976)/publications"},"_namespace":null},{"id":10977,"version":4,"created":1554935001000,"modified":1555039768000,"deprecated":false,"name":"2-acylglycerol O-acyltransferase 2","accession":"Q3SYC2","gene":"MOGAT2","description":"Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-1.1255199797847524,"antibodyCount":106,"monoclonalCount":1,"pubmedCount":null,"jensenScore":13.346231,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":21.14047548551842,"pubTatorScore":1.1287221874697584,"self":"https://pharos.nih.gov/idg/api/v1/targets(10977)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":195,"href":"https://pharos.nih.gov/idg/api/v1/targets(10977)/properties"},"_links":{"count":829,"href":"https://pharos.nih.gov/idg/api/v1/targets(10977)/links"},"_synonyms":{"count":90,"href":"https://pharos.nih.gov/idg/api/v1/targets(10977)/synonyms"},"_publications":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10977)/publications"},"_namespace":null},{"id":10978,"version":2,"created":1554935067000,"modified":1554935070000,"deprecated":false,"name":"Laforin, isoform 9","accession":"B3EWF7","gene":"EPM2A","description":null,"idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-2.189323330479406,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":282.512936,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":2.079436803812511,"self":"https://pharos.nih.gov/idg/api/v1/targets(10978)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":198,"href":"https://pharos.nih.gov/idg/api/v1/targets(10978)/properties"},"_links":{"count":316,"href":"https://pharos.nih.gov/idg/api/v1/targets(10978)/links"},"_synonyms":{"count":26,"href":"https://pharos.nih.gov/idg/api/v1/targets(10978)/synonyms"},"_publications":{"count":77,"href":"https://pharos.nih.gov/idg/api/v1/targets(10978)/publications"},"_namespace":null},{"id":10979,"version":2,"created":1554935070000,"modified":1554935071000,"deprecated":false,"name":"Keratin, type I cytoskeletal 39","accession":"Q6A163","gene":"KRT39","description":"May play a role in late hair differentiation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-1.0547224578217262,"antibodyCount":23,"monoclonalCount":2,"pubmedCount":null,"jensenScore":10.911324,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":11.817693465284604,"pubTatorScore":1.5593222555324082,"self":"https://pharos.nih.gov/idg/api/v1/targets(10979)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":137,"href":"https://pharos.nih.gov/idg/api/v1/targets(10979)/properties"},"_links":{"count":441,"href":"https://pharos.nih.gov/idg/api/v1/targets(10979)/links"},"_synonyms":{"count":75,"href":"https://pharos.nih.gov/idg/api/v1/targets(10979)/synonyms"},"_publications":{"count":7,"href":"https://pharos.nih.gov/idg/api/v1/targets(10979)/publications"},"_namespace":null},{"id":10980,"version":2,"created":1554935072000,"modified":1554935075000,"deprecated":false,"name":"Keratin, type I cytoskeletal 40","accession":"Q6A162","gene":"KRT40","description":"May play a role in late hair differentiation.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.7578658018414347,"antibodyCount":32,"monoclonalCount":3,"pubmedCount":null,"jensenScore":5.430555,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":12.626949595466987,"pubTatorScore":1.8097280064852674,"self":"https://pharos.nih.gov/idg/api/v1/targets(10980)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":165,"href":"https://pharos.nih.gov/idg/api/v1/targets(10980)/properties"},"_links":{"count":608,"href":"https://pharos.nih.gov/idg/api/v1/targets(10980)/links"},"_synonyms":{"count":78,"href":"https://pharos.nih.gov/idg/api/v1/targets(10980)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10980)/publications"},"_namespace":null},{"id":10981,"version":2,"created":1554935075000,"modified":1554935076000,"deprecated":false,"name":"Protein FAM25A","accession":"B3EWG3","gene":"FAM25C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":10,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10981)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":114,"href":"https://pharos.nih.gov/idg/api/v1/targets(10981)/properties"},"_links":{"count":427,"href":"https://pharos.nih.gov/idg/api/v1/targets(10981)/links"},"_synonyms":{"count":62,"href":"https://pharos.nih.gov/idg/api/v1/targets(10981)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10981)/publications"},"_namespace":null},{"id":10982,"version":2,"created":1554935077000,"modified":1554935079000,"deprecated":false,"name":"Protein zyg-11 homolog A","accession":"Q6WRX3","gene":"ZYG11A","description":"Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.","idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":-0.47952732803227915,"antibodyCount":69,"monoclonalCount":0,"pubmedCount":null,"jensenScore":2.887588,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":18.522071316515547,"pubTatorScore":-0.2218487496163564,"self":"https://pharos.nih.gov/idg/api/v1/targets(10982)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":205,"href":"https://pharos.nih.gov/idg/api/v1/targets(10982)/properties"},"_links":{"count":790,"href":"https://pharos.nih.gov/idg/api/v1/targets(10982)/links"},"_synonyms":{"count":66,"href":"https://pharos.nih.gov/idg/api/v1/targets(10982)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10982)/publications"},"_namespace":null},{"id":10983,"version":2,"created":1554935080000,"modified":1554935085000,"deprecated":false,"name":"Dihydropteridine reductase","accession":"P09417","gene":"QDPR","description":"The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.","idgFamily":"Enzyme","idgTDL":"Tchem","novelty":-2.311767107239458,"antibodyCount":146,"monoclonalCount":14,"pubmedCount":null,"jensenScore":200.794403,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":39.62002844739164,"pubTatorScore":2.2103625838971532,"self":"https://pharos.nih.gov/idg/api/v1/targets(10983)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":352,"href":"https://pharos.nih.gov/idg/api/v1/targets(10983)/properties"},"_links":{"count":1032,"href":"https://pharos.nih.gov/idg/api/v1/targets(10983)/links"},"_synonyms":{"count":115,"href":"https://pharos.nih.gov/idg/api/v1/targets(10983)/synonyms"},"_publications":{"count":57,"href":"https://pharos.nih.gov/idg/api/v1/targets(10983)/publications"},"_namespace":null},{"id":10984,"version":3,"created":1554935086000,"modified":1555039769000,"deprecated":false,"name":"DNA polymerase epsilon catalytic subunit A","accession":"Q07864","gene":"POLE","description":"Participates in DNA repair and in chromosomal DNA replication.","idgFamily":"Enzyme","idgTDL":"Tclin","novelty":-2.226440997702807,"antibodyCount":112,"monoclonalCount":73,"pubmedCount":null,"jensenScore":169.323841,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":3,"knowledgeAvailability":44.170536262939784,"pubTatorScore":1.1972805581256194,"self":"https://pharos.nih.gov/idg/api/v1/targets(10984)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":422,"href":"https://pharos.nih.gov/idg/api/v1/targets(10984)/properties"},"_links":{"count":1013,"href":"https://pharos.nih.gov/idg/api/v1/targets(10984)/links"},"_synonyms":{"count":109,"href":"https://pharos.nih.gov/idg/api/v1/targets(10984)/synonyms"},"_publications":{"count":94,"href":"https://pharos.nih.gov/idg/api/v1/targets(10984)/publications"},"_namespace":null},{"id":10985,"version":2,"created":1554935097000,"modified":1554935101000,"deprecated":false,"name":"Zinc finger FYVE domain-containing protein 16","accession":"Q7Z3T8","gene":"ZFYVE16","description":"May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8458114375038496,"antibodyCount":116,"monoclonalCount":23,"pubmedCount":null,"jensenScore":9.360786,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":41.6861670848094,"pubTatorScore":0.8468392917343159,"self":"https://pharos.nih.gov/idg/api/v1/targets(10985)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":361,"href":"https://pharos.nih.gov/idg/api/v1/targets(10985)/properties"},"_links":{"count":1036,"href":"https://pharos.nih.gov/idg/api/v1/targets(10985)/links"},"_synonyms":{"count":108,"href":"https://pharos.nih.gov/idg/api/v1/targets(10985)/synonyms"},"_publications":{"count":29,"href":"https://pharos.nih.gov/idg/api/v1/targets(10985)/publications"},"_namespace":null},{"id":10986,"version":3,"created":1554935102000,"modified":1555039770000,"deprecated":false,"name":"Centromere protein H","accession":"Q9H3R5","gene":"CENPH","description":"Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.5080484866564712,"antibodyCount":232,"monoclonalCount":61,"pubmedCount":null,"jensenScore":34.581315,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":2,"knowledgeAvailability":30.846725848901613,"pubTatorScore":1.561597913496443,"self":"https://pharos.nih.gov/idg/api/v1/targets(10986)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":375,"href":"https://pharos.nih.gov/idg/api/v1/targets(10986)/properties"},"_links":{"count":1073,"href":"https://pharos.nih.gov/idg/api/v1/targets(10986)/links"},"_synonyms":{"count":73,"href":"https://pharos.nih.gov/idg/api/v1/targets(10986)/synonyms"},"_publications":{"count":40,"href":"https://pharos.nih.gov/idg/api/v1/targets(10986)/publications"},"_namespace":null},{"id":10987,"version":2,"created":1554935106000,"modified":1554935127000,"deprecated":false,"name":"Lysine-specific demethylase 4C","accession":"Q9H3R0","gene":"KDM4C","description":"Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.","idgFamily":"Epigenetic","idgTDL":"Tchem","novelty":-1.6480684801068737,"antibodyCount":208,"monoclonalCount":27,"pubmedCount":null,"jensenScore":46.195439,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":44.42376177504744,"pubTatorScore":1.6876519909172925,"self":"https://pharos.nih.gov/idg/api/v1/targets(10987)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":333,"href":"https://pharos.nih.gov/idg/api/v1/targets(10987)/properties"},"_links":{"count":955,"href":"https://pharos.nih.gov/idg/api/v1/targets(10987)/links"},"_synonyms":{"count":151,"href":"https://pharos.nih.gov/idg/api/v1/targets(10987)/synonyms"},"_publications":{"count":55,"href":"https://pharos.nih.gov/idg/api/v1/targets(10987)/publications"},"_namespace":null},{"id":10988,"version":2,"created":1554935128000,"modified":1554935133000,"deprecated":false,"name":"Mucin-13","accession":"Q9H3R2","gene":"MUC13","description":"Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.8849955937979888,"antibodyCount":181,"monoclonalCount":4,"pubmedCount":null,"jensenScore":73.30554,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":25.170371377396915,"pubTatorScore":1.28872407331231,"self":"https://pharos.nih.gov/idg/api/v1/targets(10988)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":248,"href":"https://pharos.nih.gov/idg/api/v1/targets(10988)/properties"},"_links":{"count":794,"href":"https://pharos.nih.gov/idg/api/v1/targets(10988)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10988)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10988)/publications"},"_namespace":null},{"id":10989,"version":2,"created":1554935133000,"modified":1554935133000,"deprecated":false,"name":"Putative POM121-like protein 1","accession":"Q3SYA9","gene":"POM121L1P","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":null,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":6.938578184186148,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10989)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":18,"href":"https://pharos.nih.gov/idg/api/v1/targets(10989)/properties"},"_links":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10989)/links"},"_synonyms":{"count":31,"href":"https://pharos.nih.gov/idg/api/v1/targets(10989)/synonyms"},"_publications":{"count":5,"href":"https://pharos.nih.gov/idg/api/v1/targets(10989)/publications"},"_namespace":null},{"id":10990,"version":2,"created":1554935133000,"modified":1554935135000,"deprecated":false,"name":"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4","accession":"Q9H3R1","gene":"NDST4","description":"Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-0.9258459612182776,"antibodyCount":90,"monoclonalCount":2,"pubmedCount":null,"jensenScore":7.842318,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":20.499828766210456,"pubTatorScore":0.6450945579992752,"self":"https://pharos.nih.gov/idg/api/v1/targets(10990)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":159,"href":"https://pharos.nih.gov/idg/api/v1/targets(10990)/properties"},"_links":{"count":442,"href":"https://pharos.nih.gov/idg/api/v1/targets(10990)/links"},"_synonyms":{"count":82,"href":"https://pharos.nih.gov/idg/api/v1/targets(10990)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10990)/publications"},"_namespace":null},{"id":10991,"version":2,"created":1554935136000,"modified":1554935140000,"deprecated":false,"name":"CLIP-associating protein 1","accession":"Q7Z460","gene":"CLASP1","description":"Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.2917281963988292,"antibodyCount":219,"monoclonalCount":56,"pubmedCount":null,"jensenScore":19.290629,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":46.25668095298451,"pubTatorScore":1.2194535370768107,"self":"https://pharos.nih.gov/idg/api/v1/targets(10991)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":417,"href":"https://pharos.nih.gov/idg/api/v1/targets(10991)/properties"},"_links":{"count":1187,"href":"https://pharos.nih.gov/idg/api/v1/targets(10991)/links"},"_synonyms":{"count":130,"href":"https://pharos.nih.gov/idg/api/v1/targets(10991)/synonyms"},"_publications":{"count":58,"href":"https://pharos.nih.gov/idg/api/v1/targets(10991)/publications"},"_namespace":null},{"id":10992,"version":2,"created":1554935141000,"modified":1554935143000,"deprecated":false,"name":"Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein","accession":"Q7Z465","gene":"BNIPL","description":"May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.9751769205394091,"antibodyCount":59,"monoclonalCount":26,"pubmedCount":null,"jensenScore":11.616514,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":22.59564621231921,"pubTatorScore":0.8010605985110093,"self":"https://pharos.nih.gov/idg/api/v1/targets(10992)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":230,"href":"https://pharos.nih.gov/idg/api/v1/targets(10992)/properties"},"_links":{"count":857,"href":"https://pharos.nih.gov/idg/api/v1/targets(10992)/links"},"_synonyms":{"count":95,"href":"https://pharos.nih.gov/idg/api/v1/targets(10992)/synonyms"},"_publications":{"count":13,"href":"https://pharos.nih.gov/idg/api/v1/targets(10992)/publications"},"_namespace":null},{"id":10993,"version":3,"created":1554935144000,"modified":1555039772000,"deprecated":false,"name":"Forkhead box protein D4-like 6","accession":"Q3SYB3","gene":"FOXD4L6","description":null,"idgFamily":"Transcription Factor","idgTDL":"Tdark","novelty":0.47712125471966244,"antibodyCount":7,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.25,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":13,"knowledgeAvailability":8.581810763592985,"pubTatorScore":-0.6020599913279624,"self":"https://pharos.nih.gov/idg/api/v1/targets(10993)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10993)/properties"},"_links":{"count":107,"href":"https://pharos.nih.gov/idg/api/v1/targets(10993)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10993)/synonyms"},"_publications":{"count":6,"href":"https://pharos.nih.gov/idg/api/v1/targets(10993)/publications"},"_namespace":null},{"id":10994,"version":3,"created":1554935145000,"modified":1555039772000,"deprecated":false,"name":"Enhancer of polycomb homolog 2","accession":"Q52LR7","gene":"EPC2","description":"May play a role in transcription or DNA repair.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-1.3298181822432351,"antibodyCount":51,"monoclonalCount":0,"pubmedCount":null,"jensenScore":17.483078,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":12,"knowledgeAvailability":34.502834059412926,"pubTatorScore":0.984688040063911,"self":"https://pharos.nih.gov/idg/api/v1/targets(10994)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":270,"href":"https://pharos.nih.gov/idg/api/v1/targets(10994)/properties"},"_links":{"count":875,"href":"https://pharos.nih.gov/idg/api/v1/targets(10994)/links"},"_synonyms":{"count":84,"href":"https://pharos.nih.gov/idg/api/v1/targets(10994)/synonyms"},"_publications":{"count":16,"href":"https://pharos.nih.gov/idg/api/v1/targets(10994)/publications"},"_namespace":null},{"id":10995,"version":2,"created":1554935148000,"modified":1554935149000,"deprecated":false,"name":"Protein FAM25G","accession":"B3EWG6","gene":"FAM25C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":5,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":5.917478967854108,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10995)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":61,"href":"https://pharos.nih.gov/idg/api/v1/targets(10995)/properties"},"_links":{"count":104,"href":"https://pharos.nih.gov/idg/api/v1/targets(10995)/links"},"_synonyms":{"count":54,"href":"https://pharos.nih.gov/idg/api/v1/targets(10995)/synonyms"},"_publications":{"count":2,"href":"https://pharos.nih.gov/idg/api/v1/targets(10995)/publications"},"_namespace":null},{"id":10996,"version":2,"created":1554935149000,"modified":1554935149000,"deprecated":false,"name":"Protein FAM25C","accession":"B3EWG5","gene":"FAM25C","description":null,"idgFamily":"Non-IDG","idgTDL":"Tdark","novelty":0.8450980400142568,"antibodyCount":0,"monoclonalCount":0,"pubmedCount":null,"jensenScore":0.0,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":0.0,"pubTatorScore":null,"self":"https://pharos.nih.gov/idg/api/v1/targets(10996)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":45,"href":"https://pharos.nih.gov/idg/api/v1/targets(10996)/properties"},"_links":{"count":39,"href":"https://pharos.nih.gov/idg/api/v1/targets(10996)/links"},"_synonyms":{"count":70,"href":"https://pharos.nih.gov/idg/api/v1/targets(10996)/synonyms"},"_publications":{"count":3,"href":"https://pharos.nih.gov/idg/api/v1/targets(10996)/publications"},"_namespace":null},{"id":10997,"version":3,"created":1554935149000,"modified":1555039773000,"deprecated":false,"name":"Mitochondrial tRNA-specific 2-thiouridylase 1","accession":"O75648","gene":"TRMU","description":"Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-2.1792601127301183,"antibodyCount":131,"monoclonalCount":46,"pubmedCount":null,"jensenScore":142.324598,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":4,"knowledgeAvailability":34.26122406346378,"pubTatorScore":1.4085764301301,"self":"https://pharos.nih.gov/idg/api/v1/targets(10997)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":266,"href":"https://pharos.nih.gov/idg/api/v1/targets(10997)/properties"},"_links":{"count":915,"href":"https://pharos.nih.gov/idg/api/v1/targets(10997)/links"},"_synonyms":{"count":112,"href":"https://pharos.nih.gov/idg/api/v1/targets(10997)/synonyms"},"_publications":{"count":24,"href":"https://pharos.nih.gov/idg/api/v1/targets(10997)/publications"},"_namespace":null},{"id":10998,"version":2,"created":1554935153000,"modified":1554935155000,"deprecated":false,"name":"Potassium channel subfamily K member 15","accession":"Q9H427","gene":"KCNK15","description":"Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.","idgFamily":"Ion Channel","idgTDL":"Tbio","novelty":-1.480149570442359,"antibodyCount":57,"monoclonalCount":0,"pubmedCount":null,"jensenScore":27.806053,"patentCount":1007,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":23.539356209959934,"pubTatorScore":1.4148540175211082,"self":"https://pharos.nih.gov/idg/api/v1/targets(10998)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":218,"href":"https://pharos.nih.gov/idg/api/v1/targets(10998)/properties"},"_links":{"count":773,"href":"https://pharos.nih.gov/idg/api/v1/targets(10998)/links"},"_synonyms":{"count":87,"href":"https://pharos.nih.gov/idg/api/v1/targets(10998)/synonyms"},"_publications":{"count":10,"href":"https://pharos.nih.gov/idg/api/v1/targets(10998)/publications"},"_namespace":null},{"id":10999,"version":2,"created":1554935156000,"modified":1554935159000,"deprecated":false,"name":"Regulating synaptic membrane exocytosis protein 4","accession":"Q9H426","gene":"RIMS4","description":"Regulates synaptic membrane exocytosis.","idgFamily":"Non-IDG","idgTDL":"Tbio","novelty":-0.8478525183242027,"antibodyCount":72,"monoclonalCount":0,"pubmedCount":null,"jensenScore":5.766732,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":21.365662312354335,"pubTatorScore":0.7494785989393855,"self":"https://pharos.nih.gov/idg/api/v1/targets(10999)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":255,"href":"https://pharos.nih.gov/idg/api/v1/targets(10999)/properties"},"_links":{"count":823,"href":"https://pharos.nih.gov/idg/api/v1/targets(10999)/links"},"_synonyms":{"count":85,"href":"https://pharos.nih.gov/idg/api/v1/targets(10999)/synonyms"},"_publications":{"count":9,"href":"https://pharos.nih.gov/idg/api/v1/targets(10999)/publications"},"_namespace":null},{"id":11000,"version":2,"created":1554935160000,"modified":1554935165000,"deprecated":false,"name":"U5 small nuclear ribonucleoprotein 200 kDa helicase","accession":"O75643","gene":"SNRNP200","description":"RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.","idgFamily":"Enzyme","idgTDL":"Tbio","novelty":-1.7138728565907546,"antibodyCount":45,"monoclonalCount":1,"pubmedCount":null,"jensenScore":54.43631,"patentCount":null,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":45.71919219340734,"pubTatorScore":1.5480020906692533,"self":"https://pharos.nih.gov/idg/api/v1/targets(11000)?view=full","kind":"ix.idg.models.Target","_organism":null,"_properties":{"count":458,"href":"https://pharos.nih.gov/idg/api/v1/targets(11000)/properties"},"_links":{"count":1223,"href":"https://pharos.nih.gov/idg/api/v1/targets(11000)/links"},"_synonyms":{"count":135,"href":"https://pharos.nih.gov/idg/api/v1/targets(11000)/synonyms"},"_publications":{"count":63,"href":"https://pharos.nih.gov/idg/api/v1/targets(11000)/publications"},"_namespace":null}]}